clonidine has been researched along with Reperfusion Injury in 8 studies
Clonidine: An imidazoline sympatholytic agent that stimulates ALPHA-2 ADRENERGIC RECEPTORS and central IMIDAZOLINE RECEPTORS. It is commonly used in the management of HYPERTENSION.
clonidine (amino form) : A clonidine that is 4,5-dihydro-1H-imidazol-2-amine in which one of the amino hydrogens is replaced by a 2,6-dichlorophenyl group.
Reperfusion Injury: Adverse functional, metabolic, or structural changes in tissues that result from the restoration of blood flow to the tissue (REPERFUSION) following ISCHEMIA.
| Excerpt | Relevance | Reference |
|---|---|---|
| "This study aimed to investigate the protective effects of the alpha-2 adrenergic receptor (α2-AR) agonist, clonidine, on the cerebral ischemia-reperfusion (I/R) injury and elaborate the underlying mechanisms." | 8.12 | Clonidine ameliorates cerebral ischemia-reperfusion injury by up-regulating the GluN3 subunits of NMDA receptor. ( Chen, J; Chen, Y; He, Z; Li, ZC; Yang, DD; Zhang, J; Zhao, B, 2022) |
| "This study aimed to investigate the protective effects of the alpha-2 adrenergic receptor (α2-AR) agonist, clonidine, on the cerebral ischemia-reperfusion (I/R) injury and elaborate the underlying mechanisms." | 4.12 | Clonidine ameliorates cerebral ischemia-reperfusion injury by up-regulating the GluN3 subunits of NMDA receptor. ( Chen, J; Chen, Y; He, Z; Li, ZC; Yang, DD; Zhang, J; Zhao, B, 2022) |
| "Clonidine was used to decrease mucus production associated with an ischemia/reoxygenation insult." | 1.29 | The role of the mucus gel layer in intestinal bacterial translocation. ( Dunlap, JP; Jackson, RJ; Maxson, RT; Smith, SD; Tryka, F, 1994) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 4 (50.00) | 18.2507 |
| 2000's | 2 (25.00) | 29.6817 |
| 2010's | 1 (12.50) | 24.3611 |
| 2020's | 1 (12.50) | 2.80 |
| Authors | Studies |
|---|---|
| Chen, J | 1 |
| Zhang, J | 1 |
| Yang, DD | 1 |
| Li, ZC | 1 |
| Zhao, B | 1 |
| Chen, Y | 1 |
| He, Z | 1 |
| Gourdin, M | 1 |
| Dubois, P | 1 |
| Mullier, F | 1 |
| Chatelain, B | 1 |
| Dogné, JM | 1 |
| Marchandise, B | 1 |
| Jamart, J | 1 |
| De Kock, M | 1 |
| Gao, H | 1 |
| Chen, L | 1 |
| Yang, HT | 1 |
| Maxson, RT | 1 |
| Dunlap, JP | 1 |
| Tryka, F | 1 |
| Jackson, RJ | 1 |
| Smith, SD | 1 |
| Challinor-Rogers, JL | 1 |
| Rosenfeldt, FL | 1 |
| Du, XJ | 1 |
| McPherson, GA | 1 |
| Joyeux, M | 1 |
| Godin-Ribuot, D | 1 |
| Patel, A | 1 |
| Demenge, P | 1 |
| Yellon, DM | 1 |
| Ribuot, C | 1 |
| Kocić, I | 1 |
| Chao, HM | 1 |
| Osborne, NN | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Clonidine for Tourniquet-related Pain in Children: A Pilot Study[NCT04564430] | Phase 4 | 20 participants (Anticipated) | Interventional | 2021-03-01 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 trial available for clonidine and Reperfusion Injury
| Article | Year |
|---|---|
The effect of clonidine, an alpha-2 adrenergic receptor agonist, on inflammatory response and postischemic endothelium function during early reperfusion in healthy volunteers.
Topics: Adrenergic alpha-2 Receptor Agonists; Adult; Belgium; Biomarkers; Brachial Artery; CD11b Antigen; CD | 2012 |
7 other studies available for clonidine and Reperfusion Injury
| Article | Year |
|---|---|
Clonidine ameliorates cerebral ischemia-reperfusion injury by up-regulating the GluN3 subunits of NMDA receptor.
Topics: Animals; Brain Ischemia; Clonidine; Infarction, Middle Cerebral Artery; Male; Neuroprotective Agents | 2022 |
Activation of alpha1B-adrenoceptors alleviates ischemia/reperfusion injury by limitation of mitochondrial Ca2+ overload in cardiomyocytes.
Topics: Adenosine Triphosphate; Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-Antagonists; Anima | 2007 |
The role of the mucus gel layer in intestinal bacterial translocation.
Topics: Animals; Clonidine; Escherichia coli; Gels; Intestinal Mucosa; Male; Microscopy, Electron; Mucins; M | 1994 |
Antiischemic and antiarrhythmic activities of some novel alinidine analogs in the rat heart.
Topics: Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Bradycardia; Cardiac Pacing, Artificial; Card | 1997 |
Infarct size-reducing effect of heat stress and alpha1 adrenoceptors in rats.
Topics: Adrenergic alpha-Antagonists; Animals; Clonidine; Heat Stress Disorders; Heat-Shock Proteins; HSP72 | 1998 |
Preconditioning prevents the negative inotropic action of phenylephrine in rat isolated stunned papillary muscle.
Topics: Adrenergic alpha-Antagonists; Animals; Cardiotonic Agents; Clonidine; Dioxanes; Female; Ischemic Pre | 1999 |
Topically applied clonidine protects the rat retina from ischaemia/reperfusion by stimulating alpha(2)-adrenoceptors and not by an action on imidazoline receptors.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Bridged Bicyclo Compounds; Brimoni | 2001 |