clonidine has been researched along with Reflex Sympathetic Dystrophy in 11 studies
Clonidine: An imidazoline sympatholytic agent that stimulates ALPHA-2 ADRENERGIC RECEPTORS and central IMIDAZOLINE RECEPTORS. It is commonly used in the management of HYPERTENSION.
clonidine (amino form) : A clonidine that is 4,5-dihydro-1H-imidazol-2-amine in which one of the amino hydrogens is replaced by a 2,6-dichlorophenyl group.
Reflex Sympathetic Dystrophy: A syndrome characterized by severe burning pain in an extremity accompanied by sudomotor, vasomotor, and trophic changes in bone without an associated specific nerve injury. This condition is most often precipitated by trauma to soft tissue or nerve complexes. The skin over the affected region is usually erythematous and demonstrates hypersensitivity to tactile stimuli and erythema. (Adams et al., Principles of Neurology, 6th ed, p1360; Pain 1995 Oct;63(1):127-33)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Clonidine, but not placebo, caused pain relief, sedation, and decreased blood pressure and heart rate after bolus epidural injection." | 9.07 | Epidural clonidine treatment for refractory reflex sympathetic dystrophy. ( Eisenach, JC; Jackson, K; Rauck, RL; Southern, J; Young, LD, 1993) |
| "Evidence suggests that complex regional pain syndrome (CRPS) is a manifestation of microvascular dysfunction." | 5.43 | A Novel Compound Analgesic Cream (Ketamine, Pentoxifylline, Clonidine, DMSO) for Complex Regional Pain Syndrome Patients. ( Russo, MA; Santarelli, DM, 2016) |
| "Clonidine, but not placebo, caused pain relief, sedation, and decreased blood pressure and heart rate after bolus epidural injection." | 5.07 | Epidural clonidine treatment for refractory reflex sympathetic dystrophy. ( Eisenach, JC; Jackson, K; Rauck, RL; Southern, J; Young, LD, 1993) |
| "Evidence suggests that complex regional pain syndrome (CRPS) is a manifestation of microvascular dysfunction." | 1.43 | A Novel Compound Analgesic Cream (Ketamine, Pentoxifylline, Clonidine, DMSO) for Complex Regional Pain Syndrome Patients. ( Russo, MA; Santarelli, DM, 2016) |
| "We evaluated the efficacy of local or systemic parecoxib combined with lidocaine/clonidine IV regional analgesia in complex regional pain syndrome (CRPS) type 1 in a dominant upper limb." | 1.33 | The antinociceptive effect of local or systemic parecoxib combined with lidocaine/clonidine intravenous regional analgesia for complex regional pain syndrome type I in the arm. ( Frade, LP; Lauretti, GR; Lima, ICPR; Pereira, NL, 2005) |
| "IVRA clonidine (IVRA-C) was performed on each patient up to six times (maximum of once a week for six weeks)." | 1.31 | Intravenous regional anesthesia with clonidine in the management of complex regional pain syndrome of the knee. ( Reuben, SS; Sklar, J, 2002) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 5 (45.45) | 18.2507 |
| 2000's | 4 (36.36) | 29.6817 |
| 2010's | 2 (18.18) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Russo, MA | 1 |
| Santarelli, DM | 1 |
| Nascimento, MS | 1 |
| Klamt, JG | 1 |
| Prado, WA | 1 |
| Ahmed, SU | 1 |
| Vallejo, R | 1 |
| Hord, ED | 1 |
| Frade, LP | 1 |
| Lauretti, GR | 1 |
| Lima, ICPR | 1 |
| Pereira, NL | 1 |
| Ackerman, WE | 1 |
| Ahmad, M | 1 |
| Saxen, MA | 1 |
| Campbell, RL | 1 |
| Kirkpatrick, AF | 1 |
| Miller, R | 1 |
| Rauck, RL | 1 |
| Eisenach, JC | 1 |
| Jackson, K | 1 |
| Young, LD | 1 |
| Southern, J | 1 |
| Gintautas, J | 1 |
| Housny, W | 1 |
| Kraynack, BJ | 1 |
| Reuben, SS | 1 |
| Sklar, J | 1 |
| Ueno, K | 1 |
| Miyai, K | 1 |
| Mitsuzane, K | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Hemodynamic Effect of Intrathecal Clonidine in Hypertensive Subjects: A Pilot Study to Assess Its Effectiveness in Hypertensive Subjects With Poor Blood Pressure Control (Phase II)[NCT01297335] | Phase 2 | 10 participants (Actual) | Interventional | 2011-02-28 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
"Subjects baseline blood pressure (systolic blood pressure (SBP), and diastolic blood pressure (DBP)), and blood pressures after clonidine injection was compared against baseline to assess efficacy of clonidine in refractory hypertensive subjects. Subject's blood pressure was monitored continuously after intrathecal injection of clonidine until subjects blood pressure nadir and return to pre clonidine injection level. The mean value reported below are the average changes in blood pressure from baseline (pre clonidine injection) in both SBP and DBP during post clonidine injection blood pressure monitoring for 4 hours.~Blood pressure measurements were collected every 10 minutes for first hour after injection, and every 15 minutes after the first hour, up to 4 hours were averaged to report the change from baseline." (NCT01297335)
Timeframe: Baseline, Every 10 Minutes for first hour after clonidine injection, and every 15 minutes after first hour, until 4 hours after clonidine injection
| Intervention | mm Hg (Mean) | |
|---|---|---|
| Change in mean SBP after clonidine injection | Change in DBP after clonidine injection | |
| Intrathecal Clonidine | 79 | 37 |
Subjects were asked to rate severity of two of the most common side effects of clonidine, sedation and sensation of dry mouth, at pre and post (1 hour after) intrathecal administration of clonidine. The mean changes between pre and post injection VAS ratings of sedation and sensation of dry mouth are reported below. The VAS scale ranges from 1 to 10 cm, with higher values indicating higher level of sedation and higher level of dry mouth. (NCT01297335)
Timeframe: Before clonidine injection (Baseline), and at 1 hour after clonidine injection.
| Intervention | cm (Mean) | |
|---|---|---|
| Change in level of sedation | Change in sensation of dry mouth | |
| Intrathecal Clonidine | 3.36 | 3.47 |
Likert scale is 11 point digital pain rating system that asks subjects to rate their pain from 0 to 10. Rating of 0 means no pain at all, and in increasing order, 10 would mean worst pain imaginable/ unbearable pain. (NCT01297335)
Timeframe: Pre-dose and 1 hour post injection.
| Intervention | units on a scale (Mean) | |
|---|---|---|
| Pre-injection average Likert score | Post-injection average Likert score | |
| Intrathecal Clonidine | 6.5 | 3.6 |
1 trial available for clonidine and Reflex Sympathetic Dystrophy
| Article | Year |
|---|---|
Epidural clonidine treatment for refractory reflex sympathetic dystrophy.
Topics: Adult; Analgesics; Blood Pressure; Chronic Disease; Clonidine; Heart Rate; Humans; Injections, Epidu | 1993 |
10 other studies available for clonidine and Reflex Sympathetic Dystrophy
| Article | Year |
|---|---|
A Novel Compound Analgesic Cream (Ketamine, Pentoxifylline, Clonidine, DMSO) for Complex Regional Pain Syndrome Patients.
Topics: Adrenergic alpha-Agonists; Adult; Analgesics; Anesthetics, Dissociative; Anti-Infective Agents, Loca | 2016 |
Intravenous regional block is similar to sympathetic ganglion block for pain management in patients with complex regional pain syndrome type I.
Topics: Adult; Anesthesia, Intravenous; Anesthetics, Local; Autonomic Nerve Block; Clonidine; Female; Gangli | 2010 |
Seizures after a Bier block with clonidine and lidocaine.
Topics: Adrenergic alpha-Agonists; Anesthetics, Local; Clonidine; Epilepsy, Complex Partial; Humans; Lidocai | 2004 |
The antinociceptive effect of local or systemic parecoxib combined with lidocaine/clonidine intravenous regional analgesia for complex regional pain syndrome type I in the arm.
Topics: Adrenergic alpha-Agonists; Aged; Analgesics; Anesthetics, Local; Arm; Clonidine; Cyclooxygenase 2; C | 2005 |
Recurrent postoperative CRPS I in patients with abnormal preoperative sympathetic function.
Topics: Adult; Amines; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Autonomic Nerve Block; Carpal Tu | 2008 |
An unusual case of sympathetically maintained facial pain complicated by telangiectasia.
Topics: Adult; Autonomic Nerve Block; Bupivacaine; Causalgia; Clonidine; Face; Facial Pain; Female; Humans; | 1995 |
Should epidural clonidine be used for reflex sympathetic dystrophy?
Topics: Analgesia, Epidural; Chronic Disease; Clonidine; Humans; Pain; Reflex Sympathetic Dystrophy | 1994 |
Successful treatment of reflex sympathetic dystrophy by bier block with lidocaine and clonidine.
Topics: Adult; Anesthesia, Conduction; Anesthetics, Local; Cardiography, Impedance; Clonidine; Female; Human | 1999 |
Intravenous regional anesthesia with clonidine in the management of complex regional pain syndrome of the knee.
Topics: Adult; Analgesics; Anesthesia, Conduction; Clonidine; Female; Humans; Infusions, Intravenous; Knee; | 2002 |
Phenytoin-tizanidine interaction.
Topics: Anticonvulsants; Biotransformation; Clonidine; Drug Interactions; Drug Monitoring; Female; Humans; M | 1991 |