Page last updated: 2024-10-25

clonidine and Radiculopathy

clonidine has been researched along with Radiculopathy in 2 studies

Clonidine: An imidazoline sympatholytic agent that stimulates ALPHA-2 ADRENERGIC RECEPTORS and central IMIDAZOLINE RECEPTORS. It is commonly used in the management of HYPERTENSION.
clonidine (amino form) : A clonidine that is 4,5-dihydro-1H-imidazol-2-amine in which one of the amino hydrogens is replaced by a 2,6-dichlorophenyl group.

Radiculopathy: Disease involving a spinal nerve root (see SPINAL NERVE ROOTS) which may result from compression related to INTERVERTEBRAL DISK DISPLACEMENT; SPINAL CORD INJURIES; SPINAL DISEASES; and other conditions. Clinical manifestations include radicular pain, weakness, and sensory loss referable to structures innervated by the involved nerve root.

Research

Studies (2)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	1 (50.00)	29.6817
2010's	1 (50.00)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Burgher, AH	1
Hoelzer, BC	1
Schroeder, DR	1
Wilson, GA	1
Huntoon, MA	1
Rodrigues-Filho, R	1
Campos, MM	1
Ferreira, J	1
Santos, AR	1
Bertelli, JA	1
Calixto, JB	1

Clinical Trials (1)

Trial Overview

Trial			Phase	Enrollment	Study Type	Start Date	Status
Pilot Study of Transforaminal Epidural Injection of Clonidine for the Treatment of Acute Lumbosacral Radiculopathy[NCT00588354]				26 participants (Actual)	Interventional	2006-10-31	Terminated (stopped due to Targeted enrollment was not reached.)
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Pain Disability Score at 2 Weeks as Measured by Oswestry Low Back Pain Disability Questionnaire (ODI)

This questionnaire measures a patient's permanent functional disability. The questionnaire consists of 10 sections with 6 statements each of increasing point value (from 0 to 5). The score is a percentage of the total, with higher score showing greater disability. Minimum detectable change is 10%, with a 90% CI. Change of less than this may be attributable to error in measurement. (NCT00588354)
Timeframe: 2 weeks

Intervention	Units on a scale (Mean)
2% Lidocaine and Clonidine (200 or 400 ug)	27.0
2% Lidocaine and Triamcinolone (40 mg)	21.3

Pain Disability Score at 2 Weeks as Measured by the Roland-Morris Disability Questionnaire

This scale measures functional disability due to back pain. The score of the scale is the total number of items checked, from a minimum of 0 (no disability) to a maximum of 24 (great disability). Roland MO, Morris RW. A study of the natural history of back Pain. Part 1: development of a reliable and sensitive measure of disability in low back pain. Spine 1983; 8:141-144. (NCT00588354)
Timeframe: 2 weeks

Intervention	Units on a scale (Mean)
2% Lidociane and Clonidine (200 or 400 ug)	9.6
2% Lidocaine and Triamcinolone (40 mg)	5.7

Pain Disability Score at 4 Weeks as Measured by Oswestry Low Back Pain Disability Questionnaire

Intervention	Units on a scale (Mean)
2% Lidociane and Clonidine (200 or 400 ug)	23.9
2% Lidocaine and Triamcinolone (40 mg)	17.0

Pain Disability Score at 4 Weeks as Measured by the Roland-Morris Disability Questionnaire

Intervention	Units on a scale (Mean)
2% Lidociane and Clonidine (200 or 400 ug)	9.4
2% Lidocaine and Triamcinolone (40 mg)	3.5

Pain Intensity Score at 2 Weeks as Measured by Pain Intensity Numerical Rating Scale (PI-NRS)

11-point ordinal scale measuring patient pain, ranging from 0 (no pain) to 10 (most severe/disabling pain). (NCT00588354)
Timeframe: 2 weeks

Intervention	Units on a scale (Mean)
2% Lidociane and Clonidine (200 or 400 ug)	4.1
2% Lidocaine and Triamcinolone (40 mg)	4.0

Pain Intensity Score at 4 Weeks as Measured by Pain Intensity Numerical Rating Scale (PI-NRS)

11-point ordinal scale measuring patient pain, ranging from 0 (no pain) to 10 (most severe/disabling pain). (NCT00588354)
Timeframe: 4 weeks

Intervention	Units on a scale (Mean)
2% Lidociane and Clonidine (200 or 400 ug)	4.1
2% Lidocaine and Triamcinolone (40 mg)	2.7

Pain Score at 2 Weeks as Measured by the Multidimensional Pain Inventory (MPI)

The MPI is a comprehensive instrument comprised of 12 scales divided into three parts for assessing a number of dimensions of the chronic pain experience including pain intensity, emotional distress, cognitive and functional adaptation, and social support. Reference: Kearns RO, Turk DC, Rudy TC. The West Haven-Yale Multidimensional Pain Inventory (WHYMPI). Pain 1985; 23:345-356. Subscales were not used; the DOS WHYMPI computer program version 2.1 was used to score the instrument. Scores range from 0 (no pain) to 100 (highest pain). A score of 50 is the mean for patients with chronic pain. (NCT00588354)
Timeframe: 2 weeks

Intervention	Units on a scale (Mean)
2% Lidociane and Clonidine (200 or 400 ug)	51.6
2% Lidocaine and Triamcinolone (40 mg)	56.0

Pain Score at 4 Weeks as Measured by the Multidimensional Pain Inventory (MPI)

Intervention	Units on a scale (Mean)
2% Lidociane and Clonidine (200 or 400 ug)	56.7
2% Lidocaine and Triamcinolone (40 mg)	56.9

Trials

1 trial available for clonidine and Radiculopathy

Article	Year
Transforaminal epidural clonidine versus corticosteroid for acute lumbosacral radiculopathy due to intervertebral disc herniation. Spine, 2011, Mar-01, Volume: 36, Issue:5 Topics: Acute Disease; Adrenal Cortex Hormones; Adult; Aged; Clonidine; Female; Humans; Injections, Epidural	2011

Other Studies

1 other study available for clonidine and Radiculopathy

Article	Year
Pharmacological characterisation of the rat brachial plexus avulsion model of neuropathic pain. Brain research, 2004, Aug-27, Volume: 1018, Issue:2 Topics: Acetates; Amines; Analgesics; Analysis of Variance; Animals; Brachial Plexus; Brachial Plexus Neurop	2004