clonidine has been researched along with Phantom Limb in 8 studies
Clonidine: An imidazoline sympatholytic agent that stimulates ALPHA-2 ADRENERGIC RECEPTORS and central IMIDAZOLINE RECEPTORS. It is commonly used in the management of HYPERTENSION.
clonidine (amino form) : A clonidine that is 4,5-dihydro-1H-imidazol-2-amine in which one of the amino hydrogens is replaced by a 2,6-dichlorophenyl group.
Phantom Limb: Perception of painful and nonpainful phantom sensations that occur following the complete or partial loss of a limb. The majority of individuals with an amputated extremity will experience the impression that the limb is still present, and in many cases, painful. (From Neurol Clin 1998 Nov;16(4):919-36; Brain 1998 Sep;121(Pt 9):1603-30)
| Excerpt | Relevance | Reference |
|---|---|---|
| "We report the efficacy of perioperative infusion of clonidine and bupivacaine for above-knee amputation in a patient with a history of phantom limb pain in the same extremity after a previous below-knee amputation." | 7.74 | The efficacy of postoperative perineural infusion of bupivacaine and clonidine after lower extremity amputation in preventing phantom limb and stump pain. ( Adesioye, J; Madabhushi, L; Reuben, SS; Steinberg, RB, 2007) |
| "Two cases are reported of patients with phantom limb pain after lower limb amputation and requiring surgery of their stump." | 5.29 | [Temporary relief from pain in the phantom limb after spinal anesthesia using a combination of bupivacaine and clonidine]. ( Bonnet, F; Gentili, ME, 1993) |
| "We report the efficacy of perioperative infusion of clonidine and bupivacaine for above-knee amputation in a patient with a history of phantom limb pain in the same extremity after a previous below-knee amputation." | 3.74 | The efficacy of postoperative perineural infusion of bupivacaine and clonidine after lower extremity amputation in preventing phantom limb and stump pain. ( Adesioye, J; Madabhushi, L; Reuben, SS; Steinberg, RB, 2007) |
| "Clonidine has been shown to be an effective postoperative analgesia when applied epidurally." | 2.67 | Prevention of phantom pain after major lower limb amputation by epidural infusion of diamorphine, clonidine and bupivacaine. ( Bradley, JW; Dark, CH; Jahangiri, M; Jayatunga, AP, 1994) |
| "The prevalences of complex regional pain syndrome, phantom limb pain, chronic donor-site pain, and persistent pain following total joint arthroplasty are alarmingly high." | 2.44 | Preventing the development of chronic pain after orthopaedic surgery with preventive multimodal analgesic techniques. ( Buvanendran, A; Reuben, SS, 2007) |
| "Mexiletine was used in an open-label study to evaluate its effectiveness in the treatment of this disorder." | 2.38 | Successful treatment for phantom pain. ( Davis, RW, 1993) |
| "Two cases are reported of patients with phantom limb pain after lower limb amputation and requiring surgery of their stump." | 1.29 | [Temporary relief from pain in the phantom limb after spinal anesthesia using a combination of bupivacaine and clonidine]. ( Bonnet, F; Gentili, ME, 1993) |
| "The spinal mechanism of the phantom pain origin is proved." | 1.28 | [Pathogenesis of phantom limb syndrome and its treatment]. ( Gurchin, FA; Kirsanova, GV; Naryshkin, AG; Samoĭlov, KA; Shvets, IaM; Vasilevskaia, LS, 1989) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (12.50) | 18.7374 |
| 1990's | 4 (50.00) | 18.2507 |
| 2000's | 3 (37.50) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kern, U | 1 |
| Martin, C | 1 |
| Scheicher, S | 1 |
| Müller, H | 1 |
| Madabhushi, L | 1 |
| Reuben, SS | 2 |
| Steinberg, RB | 1 |
| Adesioye, J | 1 |
| Buvanendran, A | 1 |
| Jahangiri, M | 1 |
| Jayatunga, AP | 1 |
| Bradley, JW | 1 |
| Dark, CH | 1 |
| Gentili, ME | 1 |
| Bonnet, F | 1 |
| Davis, RW | 1 |
| Vorobeĭchik, IaM | 1 |
| Kukushkin, ML | 1 |
| Reshetniak, VK | 1 |
| Ovechkin, AM | 1 |
| Gnezdilov, AV | 1 |
| Naryshkin, AG | 1 |
| Gurchin, FA | 1 |
| Samoĭlov, KA | 1 |
| Kirsanova, GV | 1 |
| Vasilevskaia, LS | 1 |
| Shvets, IaM | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Prospective, Randomized Trial of Liposomal Bupivacaine Compared to Continuous Nerve Catheters on Pain Control and Post-Operative Opioid Use in Receiving Popliteal Nerve Blocks for Below the Knee Amputation[NCT05140499] | Phase 4 | 30 participants (Anticipated) | Interventional | 2022-08-15 | Recruiting | ||
| Management of Chronic Pain in Rehabilitation Project II Management of Chronic Pain in Persons With Amputation[NCT00006427] | Phase 4 | 125 participants | Interventional | 1996-08-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for clonidine and Phantom Limb
| Article | Year |
|---|---|
Preventing the development of chronic pain after orthopaedic surgery with preventive multimodal analgesic techniques.
Topics: Acetaminophen; Adrenergic alpha-Agonists; Analgesia, Epidural; Analgesics; Anesthetics, Local; Anima | 2007 |
Successful treatment for phantom pain.
Topics: Administration, Cutaneous; Aged; Chronic Disease; Clonidine; Drug Therapy, Combination; Female; Huma | 1993 |
2 trials available for clonidine and Phantom Limb
| Article | Year |
|---|---|
Prevention of phantom pain after major lower limb amputation by epidural infusion of diamorphine, clonidine and bupivacaine.
Topics: Adult; Aged; Aged, 80 and over; Amputation, Surgical; Analgesics; Bupivacaine; Clonidine; Drug Combi | 1994 |
[The treatment of the phantom pain syndrome with tizanidine].
Topics: Adult; Aged; Analgesics; Chronic Disease; Clonidine; Double-Blind Method; Female; Humans; Male; Midd | 1997 |
4 other studies available for clonidine and Phantom Limb
| Article | Year |
|---|---|
[Long-term treatment of phantom- and stump pain with Botulinum toxin type A over 12 months. A first clinical observation].
Topics: Amputation Stumps; Amputation, Surgical; Botulinum Toxins, Type A; Clonidine; Humans; Injections, In | 2004 |
The efficacy of postoperative perineural infusion of bupivacaine and clonidine after lower extremity amputation in preventing phantom limb and stump pain.
Topics: Adjuvants, Anesthesia; Aged, 80 and over; Amputation Stumps; Analgesia, Epidural; Analgesics; Bupiva | 2007 |
[Temporary relief from pain in the phantom limb after spinal anesthesia using a combination of bupivacaine and clonidine].
Topics: Aged; Amputation, Surgical; Anesthesia, Spinal; Bupivacaine; Clonidine; Drug Therapy, Combination; H | 1993 |
[Pathogenesis of phantom limb syndrome and its treatment].
Topics: Adult; Aged; Amputation Stumps; Arm; Baclofen; Clonidine; Drug Therapy, Combination; Female; Humans; | 1989 |