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clonidine and Peripheral Nerve Injuries

clonidine has been researched along with Peripheral Nerve Injuries in 11 studies

Clonidine: An imidazoline sympatholytic agent that stimulates ALPHA-2 ADRENERGIC RECEPTORS and central IMIDAZOLINE RECEPTORS. It is commonly used in the management of HYPERTENSION.
clonidine (amino form) : A clonidine that is 4,5-dihydro-1H-imidazol-2-amine in which one of the amino hydrogens is replaced by a 2,6-dichlorophenyl group.

Peripheral Nerve Injuries: Injuries to the PERIPHERAL NERVES.

Research Excerpts

ExcerptRelevanceReference
"Intrathecal clonidine reduces tactile allodynia in animal models of neuropathic pain, and this effect is blocked by atropine."7.72Plasticity in action of intrathecal clonidine to mechanical but not thermal nociception after peripheral nerve injury. ( Conklin, D; Eisenach, JC; Paqueron, X, 2003)
"These data suggest that spinal cholinergic tone does not affect the level of mechanical allodynia after peripheral nerve injury."7.71An obligatory role for spinal cholinergic neurons in the antiallodynic effects of clonidine after peripheral nerve injury. ( Bantel, C; Eisenach, JC; Li, X; Paqueron, X; Tobin, JR; Voytko, ML, 2001)
"Neuraxial clonidine is an effective adjunct in the treatment of neuropathic pain and increases acetylcholine concentrations in cerebrospinal fluid in humans."3.72Intrathecal clonidine reduces hypersensitivity after nerve injury by a mechanism involving spinal m4 muscarinic receptors. ( Eisenach, JC; Kang, YJ, 2003)
"Intrathecal clonidine reduces tactile allodynia in animal models of neuropathic pain, and this effect is blocked by atropine."3.72Plasticity in action of intrathecal clonidine to mechanical but not thermal nociception after peripheral nerve injury. ( Conklin, D; Eisenach, JC; Paqueron, X, 2003)
"These data suggest that spinal cholinergic tone does not affect the level of mechanical allodynia after peripheral nerve injury."3.71An obligatory role for spinal cholinergic neurons in the antiallodynic effects of clonidine after peripheral nerve injury. ( Bantel, C; Eisenach, JC; Li, X; Paqueron, X; Tobin, JR; Voytko, ML, 2001)
" Furthermore, the combinations of moxonidine-morphine and clonidine-morphine resulted in substantial leftward shifts in the dose-response curves compared with those of each agonist administered separately."1.31Moxonidine, a selective imidazoline-alpha2 -adrenergic receptor agonist, produces spinal synergistic antihyperalgesia with morphine in nerve-injured mice. ( Fairbanks, CA; Grocholski, BM; Nguyen, HO; Wilcox, GL, 2000)
"3-10 microg) and clonidine (1-30 microg) were administered to obtain the dose-response curves and the 50% effective dose (ED(50)) for each drug."1.31Intrathecal carbachol and clonidine produce a synergistic antiallodynic effect in rats with a nerve ligation injury. ( Han, SM; Hwang, JH; Lee, EJ; Park, JY; Park, PH; Sim, JY, 2002)

Research

Studies (11)

TimeframeStudies, this research(%)All Research%
pre-19901 (9.09)18.7374
1990's1 (9.09)18.2507
2000's5 (45.45)29.6817
2010's4 (36.36)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Kimura, M2
Eisenach, JC7
Hayashida, KI1
Ewan, EE1
Martin, TJ1
Hayashida, K2
Peters, CM1
Gutierrez, S1
Yoshizumi, M1
Hobo, S1
Obata, H1
Kang, YJ1
Paqueron, X2
Conklin, D1
Lavand'homme, P1
Pan, HL1
Fairbanks, CA1
Nguyen, HO1
Grocholski, BM1
Wilcox, GL1
Li, X1
Bantel, C1
Tobin, JR1
Voytko, ML1
Lee, EJ1
Sim, JY1
Park, JY1
Hwang, JH1
Park, PH1
Han, SM1
Coventry, DM1
Todd, G1

Other Studies

11 other studies available for clonidine and Peripheral Nerve Injuries

ArticleYear
Gabapentin loses efficacy over time after nerve injury in rats: role of glutamate transporter-1 in the locus coeruleus.
    Pain, 2016, Volume: 157, Issue:9

    Topics: Amines; Analgesics; Animals; Antihypertensive Agents; Atropine; Bronchodilator Agents; Clonidine; CR

2016
Rewarding electrical brain stimulation in rats after peripheral nerve injury: decreased facilitation by commonly abused prescription opioids.
    Anesthesiology, 2011, Volume: 115, Issue:6

    Topics: Adenosine; Amines; Analgesics; Analgesics, Opioid; Animals; Brain; Clonidine; Cyclohexanecarboxylic

2011
Depletion of endogenous noradrenaline does not prevent spinal cord plasticity following peripheral nerve injury.
    The journal of pain, 2012, Volume: 13, Issue:1

    Topics: Acetylcholine; Adjuvants, Anesthesia; Analgesics; Animals; Anterior Horn Cells; Atropine; Brain-Deri

2012
Ondansetron reverses antihypersensitivity from clonidine in rats after peripheral nerve injury: role of γ-aminobutyric acid in α2-adrenoceptor and 5-HT3 serotonin receptor analgesia.
    Anesthesiology, 2012, Volume: 117, Issue:2

    Topics: Adrenergic alpha-2 Receptor Agonists; Analgesia; Animals; Clonidine; Disease Models, Animal; gamma-A

2012
Intrathecal clonidine reduces hypersensitivity after nerve injury by a mechanism involving spinal m4 muscarinic receptors.
    Anesthesia and analgesia, 2003, Volume: 96, Issue:5

    Topics: Adrenergic alpha-Agonists; Animals; Blotting, Western; Clonidine; Elapid Venoms; Elapidae; Injection

2003
Plasticity in action of intrathecal clonidine to mechanical but not thermal nociception after peripheral nerve injury.
    Anesthesiology, 2003, Volume: 99, Issue:1

    Topics: Acetylcholine; Adrenergic alpha-Agonists; Analgesics; Animals; Atropine; Aziridines; Behavior, Anima

2003
Intrathecal neostigmine, but not sympathectomy, relieves mechanical allodynia in a rat model of neuropathic pain.
    Anesthesiology, 1998, Volume: 89, Issue:2

    Topics: Animals; Clonidine; Injections, Spinal; Male; Neostigmine; Pain; Pain Management; Parasympathomimeti

1998
Moxonidine, a selective imidazoline-alpha2 -adrenergic receptor agonist, produces spinal synergistic antihyperalgesia with morphine in nerve-injured mice.
    Anesthesiology, 2000, Volume: 93, Issue:3

    Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-Agonists; Analgesics; Animals; Clonidine; Dru

2000
An obligatory role for spinal cholinergic neurons in the antiallodynic effects of clonidine after peripheral nerve injury.
    Anesthesiology, 2001, Volume: 94, Issue:6

    Topics: Acetylcholine; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Analgesics, Non-Narcotic; An

2001
Intrathecal carbachol and clonidine produce a synergistic antiallodynic effect in rats with a nerve ligation injury.
    Canadian journal of anaesthesia = Journal canadien d'anesthesie, 2002, Volume: 49, Issue:2

    Topics: Animals; Carbachol; Clonidine; Dose-Response Relationship, Drug; Drug Synergism; Ligation; Male; Pai

2002
Epidural clonidine in lower limb deafferentation pain.
    Anesthesia and analgesia, 1989, Volume: 69, Issue:3

    Topics: Adult; Clonidine; Humans; Injections, Epidural; Leg; Male; Pain; Peripheral Nerve Injuries

1989