clonidine has been researched along with Peripheral Nerve Injuries in 11 studies
Clonidine: An imidazoline sympatholytic agent that stimulates ALPHA-2 ADRENERGIC RECEPTORS and central IMIDAZOLINE RECEPTORS. It is commonly used in the management of HYPERTENSION.
clonidine (amino form) : A clonidine that is 4,5-dihydro-1H-imidazol-2-amine in which one of the amino hydrogens is replaced by a 2,6-dichlorophenyl group.
Peripheral Nerve Injuries: Injuries to the PERIPHERAL NERVES.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Intrathecal clonidine reduces tactile allodynia in animal models of neuropathic pain, and this effect is blocked by atropine." | 7.72 | Plasticity in action of intrathecal clonidine to mechanical but not thermal nociception after peripheral nerve injury. ( Conklin, D; Eisenach, JC; Paqueron, X, 2003) |
| "These data suggest that spinal cholinergic tone does not affect the level of mechanical allodynia after peripheral nerve injury." | 7.71 | An obligatory role for spinal cholinergic neurons in the antiallodynic effects of clonidine after peripheral nerve injury. ( Bantel, C; Eisenach, JC; Li, X; Paqueron, X; Tobin, JR; Voytko, ML, 2001) |
| "Neuraxial clonidine is an effective adjunct in the treatment of neuropathic pain and increases acetylcholine concentrations in cerebrospinal fluid in humans." | 3.72 | Intrathecal clonidine reduces hypersensitivity after nerve injury by a mechanism involving spinal m4 muscarinic receptors. ( Eisenach, JC; Kang, YJ, 2003) |
| "Intrathecal clonidine reduces tactile allodynia in animal models of neuropathic pain, and this effect is blocked by atropine." | 3.72 | Plasticity in action of intrathecal clonidine to mechanical but not thermal nociception after peripheral nerve injury. ( Conklin, D; Eisenach, JC; Paqueron, X, 2003) |
| "These data suggest that spinal cholinergic tone does not affect the level of mechanical allodynia after peripheral nerve injury." | 3.71 | An obligatory role for spinal cholinergic neurons in the antiallodynic effects of clonidine after peripheral nerve injury. ( Bantel, C; Eisenach, JC; Li, X; Paqueron, X; Tobin, JR; Voytko, ML, 2001) |
| " Furthermore, the combinations of moxonidine-morphine and clonidine-morphine resulted in substantial leftward shifts in the dose-response curves compared with those of each agonist administered separately." | 1.31 | Moxonidine, a selective imidazoline-alpha2 -adrenergic receptor agonist, produces spinal synergistic antihyperalgesia with morphine in nerve-injured mice. ( Fairbanks, CA; Grocholski, BM; Nguyen, HO; Wilcox, GL, 2000) |
| "3-10 microg) and clonidine (1-30 microg) were administered to obtain the dose-response curves and the 50% effective dose (ED(50)) for each drug." | 1.31 | Intrathecal carbachol and clonidine produce a synergistic antiallodynic effect in rats with a nerve ligation injury. ( Han, SM; Hwang, JH; Lee, EJ; Park, JY; Park, PH; Sim, JY, 2002) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (9.09) | 18.7374 |
| 1990's | 1 (9.09) | 18.2507 |
| 2000's | 5 (45.45) | 29.6817 |
| 2010's | 4 (36.36) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kimura, M | 2 |
| Eisenach, JC | 7 |
| Hayashida, KI | 1 |
| Ewan, EE | 1 |
| Martin, TJ | 1 |
| Hayashida, K | 2 |
| Peters, CM | 1 |
| Gutierrez, S | 1 |
| Yoshizumi, M | 1 |
| Hobo, S | 1 |
| Obata, H | 1 |
| Kang, YJ | 1 |
| Paqueron, X | 2 |
| Conklin, D | 1 |
| Lavand'homme, P | 1 |
| Pan, HL | 1 |
| Fairbanks, CA | 1 |
| Nguyen, HO | 1 |
| Grocholski, BM | 1 |
| Wilcox, GL | 1 |
| Li, X | 1 |
| Bantel, C | 1 |
| Tobin, JR | 1 |
| Voytko, ML | 1 |
| Lee, EJ | 1 |
| Sim, JY | 1 |
| Park, JY | 1 |
| Hwang, JH | 1 |
| Park, PH | 1 |
| Han, SM | 1 |
| Coventry, DM | 1 |
| Todd, G | 1 |
11 other studies available for clonidine and Peripheral Nerve Injuries
| Article | Year |
|---|---|
Gabapentin loses efficacy over time after nerve injury in rats: role of glutamate transporter-1 in the locus coeruleus.
Topics: Amines; Analgesics; Animals; Antihypertensive Agents; Atropine; Bronchodilator Agents; Clonidine; CR | 2016 |
Rewarding electrical brain stimulation in rats after peripheral nerve injury: decreased facilitation by commonly abused prescription opioids.
Topics: Adenosine; Amines; Analgesics; Analgesics, Opioid; Animals; Brain; Clonidine; Cyclohexanecarboxylic | 2011 |
Depletion of endogenous noradrenaline does not prevent spinal cord plasticity following peripheral nerve injury.
Topics: Acetylcholine; Adjuvants, Anesthesia; Analgesics; Animals; Anterior Horn Cells; Atropine; Brain-Deri | 2012 |
Ondansetron reverses antihypersensitivity from clonidine in rats after peripheral nerve injury: role of γ-aminobutyric acid in α2-adrenoceptor and 5-HT3 serotonin receptor analgesia.
Topics: Adrenergic alpha-2 Receptor Agonists; Analgesia; Animals; Clonidine; Disease Models, Animal; gamma-A | 2012 |
Intrathecal clonidine reduces hypersensitivity after nerve injury by a mechanism involving spinal m4 muscarinic receptors.
Topics: Adrenergic alpha-Agonists; Animals; Blotting, Western; Clonidine; Elapid Venoms; Elapidae; Injection | 2003 |
Plasticity in action of intrathecal clonidine to mechanical but not thermal nociception after peripheral nerve injury.
Topics: Acetylcholine; Adrenergic alpha-Agonists; Analgesics; Animals; Atropine; Aziridines; Behavior, Anima | 2003 |
Intrathecal neostigmine, but not sympathectomy, relieves mechanical allodynia in a rat model of neuropathic pain.
Topics: Animals; Clonidine; Injections, Spinal; Male; Neostigmine; Pain; Pain Management; Parasympathomimeti | 1998 |
Moxonidine, a selective imidazoline-alpha2 -adrenergic receptor agonist, produces spinal synergistic antihyperalgesia with morphine in nerve-injured mice.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-Agonists; Analgesics; Animals; Clonidine; Dru | 2000 |
An obligatory role for spinal cholinergic neurons in the antiallodynic effects of clonidine after peripheral nerve injury.
Topics: Acetylcholine; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Analgesics, Non-Narcotic; An | 2001 |
Intrathecal carbachol and clonidine produce a synergistic antiallodynic effect in rats with a nerve ligation injury.
Topics: Animals; Carbachol; Clonidine; Dose-Response Relationship, Drug; Drug Synergism; Ligation; Male; Pai | 2002 |
Epidural clonidine in lower limb deafferentation pain.
Topics: Adult; Clonidine; Humans; Injections, Epidural; Leg; Male; Pain; Peripheral Nerve Injuries | 1989 |