clonidine has been researched along with Peripheral Nerve Diseases in 17 studies
Clonidine: An imidazoline sympatholytic agent that stimulates ALPHA-2 ADRENERGIC RECEPTORS and central IMIDAZOLINE RECEPTORS. It is commonly used in the management of HYPERTENSION.
clonidine (amino form) : A clonidine that is 4,5-dihydro-1H-imidazol-2-amine in which one of the amino hydrogens is replaced by a 2,6-dichlorophenyl group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Intrathecal clonidine reduces tactile allodynia in animal models of neuropathic pain, and this effect is blocked by atropine." | 7.72 | Plasticity in action of intrathecal clonidine to mechanical but not thermal nociception after peripheral nerve injury. ( Conklin, D; Eisenach, JC; Paqueron, X, 2003) |
| "Intrathecally administered alpha2-adrenergic receptor subtype-specific antagonists were used to determine which alpha2-adrenergic receptor subtype mediates the analgesic effect of intrathecally administered tizanidine in a chronic constriction injury (CCI) rat model of neuropathic pain." | 7.72 | Alpha2-adrenergic receptor subtype specificity of intrathecally administered tizanidine used for analgesia for neuropathic pain. ( Dills, CV; Leiphart, JW; Levy, RM, 2004) |
| "Although intrathecal clonidine produces pronounced analgesia, antinociceptive doses of intrathecal clonidine produce several side effects, including hypotension, bradycardia, and sedation." | 3.72 | Antihyperalgesic and side effects of intrathecal clonidine and tizanidine in a rat model of neuropathic pain. ( Kawamata, T; Namiki, A; Omote, K; Toriyabe, M; Wada, K; Yamamoto, H, 2003) |
| "Intrathecal clonidine reduces tactile allodynia in animal models of neuropathic pain, and this effect is blocked by atropine." | 3.72 | Plasticity in action of intrathecal clonidine to mechanical but not thermal nociception after peripheral nerve injury. ( Conklin, D; Eisenach, JC; Paqueron, X, 2003) |
| "Intrathecally administered alpha2-adrenergic receptor subtype-specific antagonists were used to determine which alpha2-adrenergic receptor subtype mediates the analgesic effect of intrathecally administered tizanidine in a chronic constriction injury (CCI) rat model of neuropathic pain." | 3.72 | Alpha2-adrenergic receptor subtype specificity of intrathecally administered tizanidine used for analgesia for neuropathic pain. ( Dills, CV; Leiphart, JW; Levy, RM, 2004) |
| "Many drugs approved for neuropathic pain engage spinal noradrenergic and cholinergic systems for analgesia." | 1.37 | A tropomyosine receptor kinase inhibitor blocks spinal neuroplasticity essential for the anti-hypersensitivity effects of gabapentin and clonidine in rats with peripheral nerve injury. ( Eisenach, JC; Hayashida, K, 2011) |
| " In this study, we investigated the dose-response characteristics of IT clonidine, and whether a subeffective dose of clonidine could enhance the effect of SCS in nerve-injured rats with tactile hypersensitivity (allodynia)." | 1.32 | Intrathecal clonidine potentiates suppression of tactile hypersensitivity by spinal cord stimulation in a model of neuropathy. ( Linderoth, B; Meyerson, BA; Schechtmann, G; Wallin, J, 2004) |
| " After recovery from catheter implantations (5-7 days), intrathecal dose-response curves were established for the antihyperesthesia effects of clonidine (3, 6, 10, and 20 micrograms) and MK-801 (1, 3, 10, and 20 micrograms) alone to obtain the ED50 for each agent." | 1.29 | Analysis of drug interaction between intrathecal clonidine and MK-801 in peripheral neuropathic pain rat model. ( Lee, YW; Yaksh, TL, 1995) |
| "Morphine pre-treatment was less effective in preventing development of hyperalgesia; however, whilst the ipsilateral (146 +/- 18 g) paw withdrawal threshold tended to be lower than the contralateral (183 +/- 8 g), this was not significant." | 1.29 | Pre-emptive administration of clonidine prevents development of hyperalgesia to mechanical stimuli in a model of mononeuropathy in the rat. ( Birch, PJ; Elliott, PJ; Harrison, SM; Smith, GD; Wiseman, J, 1993) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (5.88) | 18.7374 |
| 1990's | 4 (23.53) | 18.2507 |
| 2000's | 9 (52.94) | 29.6817 |
| 2010's | 3 (17.65) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Prommer, EE | 1 |
| Schechtmann, G | 2 |
| Lind, G | 1 |
| Winter, J | 1 |
| Meyerson, BA | 2 |
| Linderoth, B | 2 |
| Hayashida, K | 1 |
| Eisenach, JC | 4 |
| Wei, H | 1 |
| Viisanen, H | 1 |
| Amorim, D | 1 |
| Koivisto, A | 1 |
| Pertovaara, A | 1 |
| Duflo, F | 1 |
| Li, X | 1 |
| Bantel, C | 1 |
| Pancaro, C | 1 |
| Vincler, M | 1 |
| Jevtovic-Todorovic, V | 1 |
| Meyenburg, AP | 1 |
| Olney, JW | 1 |
| Wozniak, DF | 1 |
| Kawamata, T | 1 |
| Omote, K | 1 |
| Yamamoto, H | 1 |
| Toriyabe, M | 1 |
| Wada, K | 1 |
| Namiki, A | 1 |
| Paqueron, X | 1 |
| Conklin, D | 1 |
| Wallin, J | 1 |
| Leiphart, JW | 1 |
| Dills, CV | 1 |
| Levy, RM | 1 |
| Inomata, S | 1 |
| Kakiuchi, Y | 1 |
| Miyabe, M | 1 |
| Ohara, Y | 1 |
| Sukegawa, I | 1 |
| Osaka, Y | 1 |
| Kohda, Y | 1 |
| Toyooka, H | 1 |
| Clark, BG | 1 |
| Vestal, RE | 1 |
| Kayser, V | 1 |
| Desmeules, J | 1 |
| Guilbaud, G | 1 |
| Lee, YW | 1 |
| Yaksh, TL | 1 |
| Smith, GD | 1 |
| Harrison, SM | 1 |
| Wiseman, J | 1 |
| Elliott, PJ | 1 |
| Birch, PJ | 1 |
| Pan, HL | 1 |
| Chen, SR | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Dexmedetomidine Comme Adjuvant à la rachianesthésie Lors de césariennes électives : Une étude Pilote[NCT05099055] | Phase 3 | 42 participants (Actual) | Interventional | 2022-03-15 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 trial available for clonidine and Peripheral Nerve Diseases
| Article | Year |
|---|---|
Intrathecal clonidine and baclofen enhance the pain-relieving effect of spinal cord stimulation: a comparative placebo-controlled, randomized trial.
Topics: Adrenergic alpha-Agonists; Adult; Aged; Baclofen; Clonidine; Double-Blind Method; Electric Stimulati | 2010 |
16 other studies available for clonidine and Peripheral Nerve Diseases
| Article | Year |
|---|---|
Topical analgesic combinations for bortezomib neuropathy.
Topics: Administration, Topical; Adrenergic alpha-Agonists; Amines; Analgesics; Boronic Acids; Bortezomib; C | 2009 |
A tropomyosine receptor kinase inhibitor blocks spinal neuroplasticity essential for the anti-hypersensitivity effects of gabapentin and clonidine in rats with peripheral nerve injury.
Topics: Acetylcholine; Amines; Analgesics; Animals; Carbazoles; Choline O-Acetyltransferase; Clonidine; Cycl | 2011 |
Dissociated modulation of conditioned place-preference and mechanical hypersensitivity by a TRPA1 channel antagonist in peripheral neuropathy.
Topics: Acetanilides; Adrenergic alpha-2 Receptor Agonists; Animals; Clonidine; Conditioning, Psychological; | 2013 |
Peripheral nerve injury alters the alpha2 adrenoceptor subtype activated by clonidine for analgesia.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Analgesics; Animals; Behavior, Animal; Clon | 2002 |
Anti-parkinsonian agents procyclidine and ethopropazine alleviate thermal hyperalgesia in neuropathic rats.
Topics: Adrenergic alpha-Agonists; Animals; Antiparkinson Agents; Clonidine; Constriction, Pathologic; Dose- | 2003 |
Antihyperalgesic and side effects of intrathecal clonidine and tizanidine in a rat model of neuropathic pain.
Topics: Adrenergic alpha-Agonists; Analgesics; Animals; Behavior, Animal; Blood Pressure; Bradycardia; Cloni | 2003 |
Plasticity in action of intrathecal clonidine to mechanical but not thermal nociception after peripheral nerve injury.
Topics: Acetylcholine; Adrenergic alpha-Agonists; Analgesics; Animals; Atropine; Aziridines; Behavior, Anima | 2003 |
Intrathecal clonidine potentiates suppression of tactile hypersensitivity by spinal cord stimulation in a model of neuropathy.
Topics: Adrenergic alpha-Agonists; Animals; Clonidine; Dose-Response Relationship, Drug; Electric Stimulatio | 2004 |
Alpha2-adrenergic receptor subtype specificity of intrathecally administered tizanidine used for analgesia for neuropathic pain.
Topics: Adrenergic alpha-Agonists; Analgesia; Animals; Clonidine; Disease Models, Animal; Injections, Spinal | 2004 |
Combined therapy with clonidine and amantadine may act in two stages of glutamate-mediated neuropathic pain caused by a needle puncture in an upper extremity.
Topics: Adrenergic alpha-Agonists; Adult; Amantadine; Analgesics, Non-Narcotic; Calcium Channel Blockers; Ca | 2005 |
Adverse drug reactions in the elderly: case studies.
Topics: Acetazolamide; Aged; Anemia, Hemolytic; Bromocriptine; Captopril; Chlorpropamide; Cimetidine; Clonid | 1984 |
Systemic clonidine differentially modulates the abnormal reactions to mechanical and thermal stimuli in rats with peripheral mononeuropathy.
Topics: Adrenergic alpha-Antagonists; Analysis of Variance; Animals; Clonidine; Cold Temperature; Dioxanes; | 1995 |
Analysis of drug interaction between intrathecal clonidine and MK-801 in peripheral neuropathic pain rat model.
Topics: Animals; Clonidine; Dizocilpine Maleate; Drug Interactions; Drug Synergism; Injections, Spinal; Male | 1995 |
Pre-emptive administration of clonidine prevents development of hyperalgesia to mechanical stimuli in a model of mononeuropathy in the rat.
Topics: Analysis of Variance; Animals; Baclofen; Carbamazepine; Clonidine; Disease Models, Animal; Hyperalge | 1993 |
Role of spinal NO in antiallodynic effect of intrathecal clonidine in neuropathic rats.
Topics: Adrenergic alpha-Agonists; Analgesics; Animals; Clonidine; Enzyme Inhibitors; Injections, Spinal; Ma | 1998 |
Gel for neuropathy studied.
Topics: Administration, Topical; Clinical Trials, Phase III as Topic; Clonidine; Female; Gels; HIV Infection | 2000 |