clonidine has been researched along with Paraplegia in 16 studies
Clonidine: An imidazoline sympatholytic agent that stimulates ALPHA-2 ADRENERGIC RECEPTORS and central IMIDAZOLINE RECEPTORS. It is commonly used in the management of HYPERTENSION.
clonidine (amino form) : A clonidine that is 4,5-dihydro-1H-imidazol-2-amine in which one of the amino hydrogens is replaced by a 2,6-dichlorophenyl group.
Paraplegia: Severe or complete loss of motor function in the lower extremities and lower portions of the trunk. This condition is most often associated with SPINAL CORD DISEASES, although BRAIN DISEASES; PERIPHERAL NERVOUS SYSTEM DISEASES; NEUROMUSCULAR DISEASES; and MUSCULAR DISEASES may also cause bilateral leg weakness.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To report a case of possible clonidine-induced hypertension (by Naranjo score) in a patient with a C4 spinal lesion." | 7.71 | Clonidine-induced hypertension in a patient with a spinal lesion. ( Backo, AL; Clause, SL; Gibbs, KA; Triller, DM, 2002) |
| "To report a case of possible clonidine-induced hypertension (by Naranjo score) in a patient with a C4 spinal lesion." | 3.71 | Clonidine-induced hypertension in a patient with a spinal lesion. ( Backo, AL; Clause, SL; Gibbs, KA; Triller, DM, 2002) |
| ") injection of clonidine (30, 60 and 90 microg) on the polysynaptic spinal reflexes (PSR) elicited by electrical stimulation of flexor reflex afferents (FRA), monosynaptic reflex and gait of 11 subjects with spinal cord injuries." | 3.70 | Effects of intrathecal clonidine injection on spinal reflexes and human locomotion in incomplete paraplegic subjects. ( Barbeau, H; Boiteau, F; Bussel, B; Daniel, O; Rémy-Néris, O, 1999) |
| "All 3 spastic paretic patients had kinematic deviations and abnormal EMG recruitment profiles during the premedication or placebo sessions." | 2.67 | Modulation of locomotor patterns and spasticity with clonidine in spinal cord injured patients. ( Barbeau, H; Gauthier, S; Stewart, JE, 1991) |
| " The study consisted of 4 parts: I, double-blind cross-over trial at maximal dosage 10 mg/day in 13 patients; II, open trial at maximal dosage 32 mg/day in 10 patients; III, long-term medication at dosage 32 mg/day for 6-15 months in 4 patients; IV, single dose (12 mg) administration in 3 patients." | 2.65 | Antiparetic and antispastic effects induced by tizanidine in patients with spastic paresis. ( Gransberg, L; Knutsson, E; Mårtensson, A, 1982) |
| "This led to successfully oral treatment of the orthostatic hypotension with clonidine 150 micrograms bd and midodrine 10 mg bd." | 1.28 | Pharmacological evidence of alpha 1- and alpha 2-adrenergic supersensitivity in orthostatic hypotension due to spinal cord injury: a case report. ( Arias, A; Berlan, M; Montastruc, JL; Rascol, A; Senard, JM; Tran, MA, 1991) |
| "Clonidine was used as an adjunct to baclofen in 55 patients with spasticity due to spinal cord injury." | 1.27 | Clonidine effect on spasticity: a clinical trial. ( Carter, RE; Donovan, WH; Rossi, CD; Wilkerson, MA, 1988) |
| "The paroxysmal hypertension is believed to have resulted from the synergistic effect of the high levels of circulating catecholamines from the tumor and the disruption of autonomic pathways." | 1.27 | Autonomic dysreflexia in a paraplegic man with catecholamine-secreting neuroblastoma. ( Agre, JC; Theologides, A; Wilson, BC; Wright, KC, 1986) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (31.25) | 18.7374 |
| 1990's | 4 (25.00) | 18.2507 |
| 2000's | 5 (31.25) | 29.6817 |
| 2010's | 1 (6.25) | 24.3611 |
| 2020's | 1 (6.25) | 2.80 |
| Authors | Studies |
|---|---|
| Kwaśniewska, A | 1 |
| Miazga, K | 1 |
| Majczyński, H | 1 |
| Jordan, LM | 1 |
| Zawadzka, M | 1 |
| Sławińska, U | 1 |
| Fuchigami, T | 1 |
| Kakinohana, O | 1 |
| Hefferan, MP | 1 |
| Lukacova, N | 1 |
| Marsala, S | 1 |
| Platoshyn, O | 1 |
| Sugahara, K | 1 |
| Yaksh, TL | 1 |
| Marsala, M | 1 |
| Backo, AL | 1 |
| Clause, SL | 1 |
| Triller, DM | 1 |
| Gibbs, KA | 1 |
| Rémy-Néris, O | 2 |
| Denys, P | 1 |
| Daniel, O | 2 |
| Barbeau, H | 3 |
| Bussel, B | 2 |
| Parisod, E | 1 |
| Siddall, PJ | 1 |
| Viney, M | 1 |
| McClelland, JM | 1 |
| Cousins, MJ | 1 |
| Bevacqua, BK | 1 |
| Fattouh, M | 1 |
| Backonja, M | 1 |
| Knutsson, E | 1 |
| Mårtensson, A | 1 |
| Gransberg, L | 1 |
| Boiteau, F | 1 |
| Roche, WJ | 1 |
| Nwofia, C | 1 |
| Gittler, M | 1 |
| Patel, R | 1 |
| Yarkony, G | 1 |
| Metz, SA | 1 |
| Halter, JB | 1 |
| Robertson, RP | 1 |
| Senard, JM | 1 |
| Arias, A | 1 |
| Berlan, M | 1 |
| Tran, MA | 1 |
| Rascol, A | 1 |
| Montastruc, JL | 1 |
| Stewart, JE | 1 |
| Gauthier, S | 1 |
| Petros, AJ | 1 |
| Wright, RM | 1 |
| Donovan, WH | 1 |
| Carter, RE | 1 |
| Rossi, CD | 1 |
| Wilkerson, MA | 1 |
| Wright, KC | 1 |
| Agre, JC | 1 |
| Wilson, BC | 1 |
| Theologides, A | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Dose Response to the Norepinephrine Precursor Droxidopa in Hypotensive Individuals With Spinal Cord Injury[NCT03602014] | Phase 4 | 22 participants (Actual) | Interventional | 2018-06-01 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 trials available for clonidine and Paraplegia
| Article | Year |
|---|---|
Effect of intrathecal clonidine on group I and group II oligosynaptic excitation in paraplegics.
Topics: Adrenergic alpha-Agonists; Adult; Afferent Pathways; Aged; Clonidine; Electric Stimulation; Female; | 2003 |
Antiparetic and antispastic effects induced by tizanidine in patients with spastic paresis.
Topics: Adult; Aged; Clinical Trials as Topic; Clonidine; Dose-Response Relationship, Drug; Double-Blind Met | 1982 |
Modulation of locomotor patterns and spasticity with clonidine in spinal cord injured patients.
Topics: Adult; Clonidine; Double-Blind Method; Electromyography; Humans; Locomotion; Male; Middle Aged; Musc | 1991 |
13 other studies available for clonidine and Paraplegia
| Article | Year |
|---|---|
Noradrenergic Components of Locomotor Recovery Induced by Intraspinal Grafting of the Embryonic Brainstem in Adult Paraplegic Rats.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Animals; Brain Stem; | 2020 |
Potent suppression of stretch reflex activity after systemic or spinal delivery of tizanidine in rats with spinal ischemia-induced chronic spastic paraplegia.
Topics: Animals; Chronic Disease; Clonidine; Disease Models, Animal; Male; Muscle Relaxants, Central; Neural | 2011 |
Clonidine-induced hypertension in a patient with a spinal lesion.
Topics: Adrenergic alpha-Agonists; Adult; Blood Pressure; Chronic Disease; Clonidine; Fructose; Humans; Hype | 2002 |
Allodynia after acute intrathecal morphine administration in a patient with neuropathic pain after spinal cord injury.
Topics: Adrenergic alpha-Agonists; Aged; Analgesics, Opioid; Anesthetics, Local; Clonidine; Humans; Injectio | 2003 |
Depression, night terrors, and insomnia associated with long-term intrathecal clonidine therapy.
Topics: Aged; Analgesics; Aortic Aneurysm, Thoracic; Catheterization; Clonidine; Humans; Male; Neuritis; Pai | 2007 |
[Current data on bipolar disorders, epilepsy and spasm. 4th Neuro-Forum, Dresden].
Topics: Baclofen; Benzodiazepines; Bipolar Disorder; Clonidine; Epilepsy; Humans; Muscle Relaxants, Central; | 1999 |
Effects of intrathecal clonidine injection on spinal reflexes and human locomotion in incomplete paraplegic subjects.
Topics: Adrenergic alpha-Agonists; Adult; Aged; Clonidine; Electromyography; Female; Gait; Humans; Injection | 1999 |
Catecholamine-induced hypertension in lumbosacral paraplegia: five case reports.
Topics: Adolescent; Adrenergic alpha-Agonists; Adult; Blood Pressure; Catecholamines; Clonidine; Humans; Hyp | 2000 |
Induction of defective insulin secretion and impaired glucose tolerance by clonidine. Selective stimulation of metabolic alpha-adrenergic pathways.
Topics: Adult; Blood Glucose; Clonidine; Glucagon; Humans; Insulin; Male; Middle Aged; Paraplegia; Phentolam | 1978 |
Pharmacological evidence of alpha 1- and alpha 2-adrenergic supersensitivity in orthostatic hypotension due to spinal cord injury: a case report.
Topics: Blood Pressure; Chronic Disease; Clonidine; Efferent Pathways; Humans; Hypotension, Orthostatic; Mal | 1991 |
Epidural and oral clonidine in domiciliary control of deafferentation pain.
Topics: Administration, Oral; Adult; Afferent Pathways; Clonidine; Home Care Services; Humans; Infusions, In | 1987 |
Clonidine effect on spasticity: a clinical trial.
Topics: Adolescent; Adult; Aged; Clonidine; Female; Humans; Male; Middle Aged; Muscle Spasticity; Paraplegia | 1988 |
Autonomic dysreflexia in a paraplegic man with catecholamine-secreting neuroblastoma.
Topics: Adult; Autonomic Nervous System Diseases; Catecholamines; Clonidine; Humans; Hypertension; Male; Neu | 1986 |