Page last updated: 2024-10-25

clonidine and Paraplegia

clonidine has been researched along with Paraplegia in 16 studies

Clonidine: An imidazoline sympatholytic agent that stimulates ALPHA-2 ADRENERGIC RECEPTORS and central IMIDAZOLINE RECEPTORS. It is commonly used in the management of HYPERTENSION.
clonidine (amino form) : A clonidine that is 4,5-dihydro-1H-imidazol-2-amine in which one of the amino hydrogens is replaced by a 2,6-dichlorophenyl group.

Paraplegia: Severe or complete loss of motor function in the lower extremities and lower portions of the trunk. This condition is most often associated with SPINAL CORD DISEASES, although BRAIN DISEASES; PERIPHERAL NERVOUS SYSTEM DISEASES; NEUROMUSCULAR DISEASES; and MUSCULAR DISEASES may also cause bilateral leg weakness.

Research Excerpts

ExcerptRelevanceReference
"To report a case of possible clonidine-induced hypertension (by Naranjo score) in a patient with a C4 spinal lesion."7.71Clonidine-induced hypertension in a patient with a spinal lesion. ( Backo, AL; Clause, SL; Gibbs, KA; Triller, DM, 2002)
"To report a case of possible clonidine-induced hypertension (by Naranjo score) in a patient with a C4 spinal lesion."3.71Clonidine-induced hypertension in a patient with a spinal lesion. ( Backo, AL; Clause, SL; Gibbs, KA; Triller, DM, 2002)
") injection of clonidine (30, 60 and 90 microg) on the polysynaptic spinal reflexes (PSR) elicited by electrical stimulation of flexor reflex afferents (FRA), monosynaptic reflex and gait of 11 subjects with spinal cord injuries."3.70Effects of intrathecal clonidine injection on spinal reflexes and human locomotion in incomplete paraplegic subjects. ( Barbeau, H; Boiteau, F; Bussel, B; Daniel, O; Rémy-Néris, O, 1999)
"All 3 spastic paretic patients had kinematic deviations and abnormal EMG recruitment profiles during the premedication or placebo sessions."2.67Modulation of locomotor patterns and spasticity with clonidine in spinal cord injured patients. ( Barbeau, H; Gauthier, S; Stewart, JE, 1991)
" The study consisted of 4 parts: I, double-blind cross-over trial at maximal dosage 10 mg/day in 13 patients; II, open trial at maximal dosage 32 mg/day in 10 patients; III, long-term medication at dosage 32 mg/day for 6-15 months in 4 patients; IV, single dose (12 mg) administration in 3 patients."2.65Antiparetic and antispastic effects induced by tizanidine in patients with spastic paresis. ( Gransberg, L; Knutsson, E; Mårtensson, A, 1982)
"This led to successfully oral treatment of the orthostatic hypotension with clonidine 150 micrograms bd and midodrine 10 mg bd."1.28Pharmacological evidence of alpha 1- and alpha 2-adrenergic supersensitivity in orthostatic hypotension due to spinal cord injury: a case report. ( Arias, A; Berlan, M; Montastruc, JL; Rascol, A; Senard, JM; Tran, MA, 1991)
"Clonidine was used as an adjunct to baclofen in 55 patients with spasticity due to spinal cord injury."1.27Clonidine effect on spasticity: a clinical trial. ( Carter, RE; Donovan, WH; Rossi, CD; Wilkerson, MA, 1988)
"The paroxysmal hypertension is believed to have resulted from the synergistic effect of the high levels of circulating catecholamines from the tumor and the disruption of autonomic pathways."1.27Autonomic dysreflexia in a paraplegic man with catecholamine-secreting neuroblastoma. ( Agre, JC; Theologides, A; Wilson, BC; Wright, KC, 1986)

Research

Studies (16)

TimeframeStudies, this research(%)All Research%
pre-19905 (31.25)18.7374
1990's4 (25.00)18.2507
2000's5 (31.25)29.6817
2010's1 (6.25)24.3611
2020's1 (6.25)2.80

Authors

AuthorsStudies
Kwaśniewska, A1
Miazga, K1
Majczyński, H1
Jordan, LM1
Zawadzka, M1
Sławińska, U1
Fuchigami, T1
Kakinohana, O1
Hefferan, MP1
Lukacova, N1
Marsala, S1
Platoshyn, O1
Sugahara, K1
Yaksh, TL1
Marsala, M1
Backo, AL1
Clause, SL1
Triller, DM1
Gibbs, KA1
Rémy-Néris, O2
Denys, P1
Daniel, O2
Barbeau, H3
Bussel, B2
Parisod, E1
Siddall, PJ1
Viney, M1
McClelland, JM1
Cousins, MJ1
Bevacqua, BK1
Fattouh, M1
Backonja, M1
Knutsson, E1
Mårtensson, A1
Gransberg, L1
Boiteau, F1
Roche, WJ1
Nwofia, C1
Gittler, M1
Patel, R1
Yarkony, G1
Metz, SA1
Halter, JB1
Robertson, RP1
Senard, JM1
Arias, A1
Berlan, M1
Tran, MA1
Rascol, A1
Montastruc, JL1
Stewart, JE1
Gauthier, S1
Petros, AJ1
Wright, RM1
Donovan, WH1
Carter, RE1
Rossi, CD1
Wilkerson, MA1
Wright, KC1
Agre, JC1
Wilson, BC1
Theologides, A1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Dose Response to the Norepinephrine Precursor Droxidopa in Hypotensive Individuals With Spinal Cord Injury[NCT03602014]Phase 422 participants (Actual)Interventional2018-06-01Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trials

3 trials available for clonidine and Paraplegia

ArticleYear
Effect of intrathecal clonidine on group I and group II oligosynaptic excitation in paraplegics.
    Experimental brain research, 2003, Volume: 148, Issue:4

    Topics: Adrenergic alpha-Agonists; Adult; Afferent Pathways; Aged; Clonidine; Electric Stimulation; Female;

2003
Antiparetic and antispastic effects induced by tizanidine in patients with spastic paresis.
    Journal of the neurological sciences, 1982, Volume: 53, Issue:2

    Topics: Adult; Aged; Clinical Trials as Topic; Clonidine; Dose-Response Relationship, Drug; Double-Blind Met

1982
Modulation of locomotor patterns and spasticity with clonidine in spinal cord injured patients.
    The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques, 1991, Volume: 18, Issue:3

    Topics: Adult; Clonidine; Double-Blind Method; Electromyography; Humans; Locomotion; Male; Middle Aged; Musc

1991

Other Studies

13 other studies available for clonidine and Paraplegia

ArticleYear
Noradrenergic Components of Locomotor Recovery Induced by Intraspinal Grafting of the Embryonic Brainstem in Adult Paraplegic Rats.
    International journal of molecular sciences, 2020, Aug-01, Volume: 21, Issue:15

    Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Animals; Brain Stem;

2020
Potent suppression of stretch reflex activity after systemic or spinal delivery of tizanidine in rats with spinal ischemia-induced chronic spastic paraplegia.
    Neuroscience, 2011, Oct-27, Volume: 194

    Topics: Animals; Chronic Disease; Clonidine; Disease Models, Animal; Male; Muscle Relaxants, Central; Neural

2011
Clonidine-induced hypertension in a patient with a spinal lesion.
    The Annals of pharmacotherapy, 2002, Volume: 36, Issue:9

    Topics: Adrenergic alpha-Agonists; Adult; Blood Pressure; Chronic Disease; Clonidine; Fructose; Humans; Hype

2002
Allodynia after acute intrathecal morphine administration in a patient with neuropathic pain after spinal cord injury.
    Anesthesia and analgesia, 2003, Volume: 97, Issue:1

    Topics: Adrenergic alpha-Agonists; Aged; Analgesics, Opioid; Anesthetics, Local; Clonidine; Humans; Injectio

2003
Depression, night terrors, and insomnia associated with long-term intrathecal clonidine therapy.
    Pain practice : the official journal of World Institute of Pain, 2007, Volume: 7, Issue:1

    Topics: Aged; Analgesics; Aortic Aneurysm, Thoracic; Catheterization; Clonidine; Humans; Male; Neuritis; Pai

2007
[Current data on bipolar disorders, epilepsy and spasm. 4th Neuro-Forum, Dresden].
    Psychiatrische Praxis, 1999, Volume: 26, Issue:3 Suppl

    Topics: Baclofen; Benzodiazepines; Bipolar Disorder; Clonidine; Epilepsy; Humans; Muscle Relaxants, Central;

1999
Effects of intrathecal clonidine injection on spinal reflexes and human locomotion in incomplete paraplegic subjects.
    Experimental brain research, 1999, Volume: 129, Issue:3

    Topics: Adrenergic alpha-Agonists; Adult; Aged; Clonidine; Electromyography; Female; Gait; Humans; Injection

1999
Catecholamine-induced hypertension in lumbosacral paraplegia: five case reports.
    Archives of physical medicine and rehabilitation, 2000, Volume: 81, Issue:2

    Topics: Adolescent; Adrenergic alpha-Agonists; Adult; Blood Pressure; Catecholamines; Clonidine; Humans; Hyp

2000
Induction of defective insulin secretion and impaired glucose tolerance by clonidine. Selective stimulation of metabolic alpha-adrenergic pathways.
    Diabetes, 1978, Volume: 27, Issue:5

    Topics: Adult; Blood Glucose; Clonidine; Glucagon; Humans; Insulin; Male; Middle Aged; Paraplegia; Phentolam

1978
Pharmacological evidence of alpha 1- and alpha 2-adrenergic supersensitivity in orthostatic hypotension due to spinal cord injury: a case report.
    European journal of clinical pharmacology, 1991, Volume: 41, Issue:6

    Topics: Blood Pressure; Chronic Disease; Clonidine; Efferent Pathways; Humans; Hypotension, Orthostatic; Mal

1991
Epidural and oral clonidine in domiciliary control of deafferentation pain.
    Lancet (London, England), 1987, May-02, Volume: 1, Issue:8540

    Topics: Administration, Oral; Adult; Afferent Pathways; Clonidine; Home Care Services; Humans; Infusions, In

1987
Clonidine effect on spasticity: a clinical trial.
    Archives of physical medicine and rehabilitation, 1988, Volume: 69, Issue:3 Pt 1

    Topics: Adolescent; Adult; Aged; Clonidine; Female; Humans; Male; Middle Aged; Muscle Spasticity; Paraplegia

1988
Autonomic dysreflexia in a paraplegic man with catecholamine-secreting neuroblastoma.
    Archives of physical medicine and rehabilitation, 1986, Volume: 67, Issue:8

    Topics: Adult; Autonomic Nervous System Diseases; Catecholamines; Clonidine; Humans; Hypertension; Male; Neu

1986