clonidine has been researched along with Pain, Postoperative in 366 studies
Clonidine: An imidazoline sympatholytic agent that stimulates ALPHA-2 ADRENERGIC RECEPTORS and central IMIDAZOLINE RECEPTORS. It is commonly used in the management of HYPERTENSION.
clonidine (amino form) : A clonidine that is 4,5-dihydro-1H-imidazol-2-amine in which one of the amino hydrogens is replaced by a 2,6-dichlorophenyl group.
Pain, Postoperative: Pain during the period after surgery.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To compare diazepam use, muscle spasm, analgesia, and side effects when clonidine or fentanyl are added to epidural bupivacaine in children with cerebral palsy after multilevel orthopaedic surgery." | 9.22 | Comparison of lumbar epidural bupivacaine with fentanyl or clonidine for postoperative analgesia in children with cerebral palsy after single-event multilevel surgery. ( Chalkiadis, GA; Dowden, SJ; Graham, HK; Low, J; Orsini, F; Penrose, S; Pirpiris, M; Sommerfield, D; Tay, M, 2016) |
| "Of the 50 patients with hypertension (American Society of Anesthesiologists class II), 25 received 2 mL of 2% lidocaine with clonidine (15 μg/mL) and 25 received lidocaine with epinephrine (12." | 9.16 | Is clonidine an adequate alternative to epinephrine as a vasoconstrictor in patients with hypertension? ( Patil, PM; Patil, SP, 2012) |
| "These findings indicate that children receiving clonidine or DEX preoperatively have similar levels of anxiety and sedation postoperatively as those receiving midazolam." | 9.12 | Effects of preanesthetic administration of midazolam, clonidine, or dexmedetomidine on postoperative pain and anxiety in children. ( Auler, JO; Bandeira, D; Bertacchi, MF; Schmidt, AP; Simões, CM; Valinetti, EA, 2007) |
| " clonidine on postoperative analgesia produced by caudal bupivacaine after hypospadias repair." | 9.11 | Caudal bupivacaine supplemented with caudal or intravenous clonidine in children undergoing hypospadias repair: a double-blind study. ( Hansen, M; Hansen, TG; Henneberg, SW; Lund, J; Walther-Larsen, S, 2004) |
| " Our hypothesis is that coinduction with clonidine reduces the incidence of PONV in adult patients undergoing breast cancer surgery." | 9.10 | Effects of clonidine on postoperative nausea and vomiting in breast cancer surgery. ( Bergendahl, HT; Eksborg, S; Lönnqvist, PA; Muhrbeck, O; Oddby-Muhrbeck, E, 2002) |
| "This is a prospective randomized double-blind trial conducted to determine whether preoperative orally administered clonidine causes or potentiates postoperative vomiting in 140 children (3-12 yr) undergoing strabismus surgery." | 9.08 | Oral clonidine premedication reduces vomiting in children after strabismus surgery. ( Asano, M; Maekawa, N; Mikawa, K; Nishina, K; Obara, H, 1995) |
| "The objective of this study was to determine whether postoperative morphine requirement in obese patients undergoing laparoscopic bariatric surgery was reduced by opioid-free anesthesia (OFA), as compared to an anesthetic strategy using opioids (opioid balanced anesthesia (OBA)) and to investigate the differences that may exist between the use of clonidine and dexmedetomidine in the context of OFA." | 8.12 | Effects of opioid-free anesthesia on postoperative morphine consumption after bariatric surgery. ( Abrard, S; Berlier, J; Bouffard, Y; Carabalona, JF; Cerro, V; Le-Goff, MC; Rimmelé, T; Subtil, F; Tête, H, 2022) |
| "We report the efficacy of perioperative infusion of clonidine and bupivacaine for above-knee amputation in a patient with a history of phantom limb pain in the same extremity after a previous below-knee amputation." | 7.74 | The efficacy of postoperative perineural infusion of bupivacaine and clonidine after lower extremity amputation in preventing phantom limb and stump pain. ( Adesioye, J; Madabhushi, L; Reuben, SS; Steinberg, RB, 2007) |
| "Clonidine can effectively reduce pain and/or hypersensitivity." | 7.74 | Effects of topical application of clonidine cream on pain behaviors and spinal Fos protein expression in rat models of neuropathic pain, postoperative pain, and inflammatory pain. ( Arita, H; Hanaoka, K; Hayashida, M; Li, C; Sawamura, S; Sekiyama, H; Sumida, T; Takeda, K; Yamada, Y, 2007) |
| "Tizanidine is a centrally acting α2-agonist with muscle relaxant properties." | 6.82 | Tizanidine for the management of acute postoperative pain after inguinal hernia repair: A placebo-controlled double-blind trial. ( Akkaya, T; Caparlar, C; Kulaçoğlu, H; Mercan, U; Yazicioğlu, D, 2016) |
| "The parameters of postoperative pain level using VAS score (visual analog scale), sedation and analgesics consumption were determined as outcome measures at 1, 2, 6, and 24 h of the operation." | 6.73 | Effects of clonidine preemptive analgesia on acute postoperative pain in abdominal surgery. ( Buković, D; Buković, N; Husedzinović, I; Pavelić, L; Persec, J; Persec, Z, 2007) |
| "We conclude that for elective inguinal hernia repair, postoperative analgesia obtained by bupivacaine wound infiltration was not improved by the addition of clonidine 150 micrograms." | 6.68 | Does the addition of clonidine affect duration of analgesia of bupivacaine wound infiltration in inguinal hernia surgery? ( Eckersall, S; Elliott, S; Fligelstone, L; Jothilingam, S, 1997) |
| "Its use in premedication and postoperative pain management may be limited by its principal effects of hypotension and bradycardia." | 6.38 | [The role of clonidine in anesthesia]. ( Heil, T; Koenigs, D; Striebel, HW, 1993) |
| "Intrathecal morphine (ITM) is a widely used technique for postcaesarean section analgesia but entails a high risk of postoperative nausea and vomiting (PONV)." | 5.30 | The impact of a transversus abdominis plane block including clonidine vs. intrathecal morphine on nausea and vomiting after caesarean section: A randomised controlled trial. ( Combescure, C; Dereu, D; Mathivon, S; Mercier, Y; Rehberg, B; Savoldelli, GL, 2019) |
| "Two cases are reported of patients with phantom limb pain after lower limb amputation and requiring surgery of their stump." | 5.29 | [Temporary relief from pain in the phantom limb after spinal anesthesia using a combination of bupivacaine and clonidine]. ( Bonnet, F; Gentili, ME, 1993) |
| "To compare diazepam use, muscle spasm, analgesia, and side effects when clonidine or fentanyl are added to epidural bupivacaine in children with cerebral palsy after multilevel orthopaedic surgery." | 5.22 | Comparison of lumbar epidural bupivacaine with fentanyl or clonidine for postoperative analgesia in children with cerebral palsy after single-event multilevel surgery. ( Chalkiadis, GA; Dowden, SJ; Graham, HK; Low, J; Orsini, F; Penrose, S; Pirpiris, M; Sommerfield, D; Tay, M, 2016) |
| "Of the 50 patients with hypertension (American Society of Anesthesiologists class II), 25 received 2 mL of 2% lidocaine with clonidine (15 μg/mL) and 25 received lidocaine with epinephrine (12." | 5.16 | Is clonidine an adequate alternative to epinephrine as a vasoconstrictor in patients with hypertension? ( Patil, PM; Patil, SP, 2012) |
| "These findings indicate that children receiving clonidine or DEX preoperatively have similar levels of anxiety and sedation postoperatively as those receiving midazolam." | 5.12 | Effects of preanesthetic administration of midazolam, clonidine, or dexmedetomidine on postoperative pain and anxiety in children. ( Auler, JO; Bandeira, D; Bertacchi, MF; Schmidt, AP; Simões, CM; Valinetti, EA, 2007) |
| " The addition of clonidine 2 microg/kg to bupivacaine provides a prolonged anesthetic action but may be associated with hypotension." | 5.12 | Clonidine 1 microg/kg is a safe and effective adjuvant to plain bupivacaine in spinal anesthesia in adolescents. ( Abdelaziz, AB; Chattaoui, O; Kaabachi, O; Kokki, H; Ouezini, R; Zarghouni, A, 2007) |
| " clonidine on postoperative analgesia produced by caudal bupivacaine after hypospadias repair." | 5.11 | Caudal bupivacaine supplemented with caudal or intravenous clonidine in children undergoing hypospadias repair: a double-blind study. ( Hansen, M; Hansen, TG; Henneberg, SW; Lund, J; Walther-Larsen, S, 2004) |
| "Forty-four children aged 1-5 years consecutively scheduled for inguinal hernia repair, hydrocele repair or orchidopexy were randomly assigned to receive a caudal injection of either S(+)-ketamine 1 mg x kg(-1) (group K) or S(+)-ketamine 0." | 5.11 | Caudal analgesia in children: S(+)-ketamine vs S(+)-ketamine plus clonidine. ( Almenrader, N; Canneti, A; Haiberger, R; Passariello, M; Pietropaoli, P; Rubeo, L, 2004) |
| "The goals of this two-part study were to determine the dose of clonidine to prevent postoperative shivering after mild hypothermia and to evaluate the effect of clonidine on recovery from anesthesia in patients undergoing surgery for intracranial lesions." | 5.11 | Intraoperative clonidine administration to neurosurgical patients. ( Brown, R; Lobo, EP; Stapelfeldt, C; Talke, PO, 2005) |
| "Using a prospective, randomized, observer-blinded study design, 40 patients, aged 1-7 years, who were undergoing elective surgery for inguinal hernia repair or orchidopexy, were randomly allocated to receive either a caudal block (group C: n = 20; ropivacaine 0." | 5.10 | Spinal versus peripheral effects of adjunct clonidine: comparison of the analgesic effect of a ropivacaine-clonidine mixture when administered as a caudal or ilioinguinal-iliohypogastric nerve blockade for inguinal surgery in children. ( Conio, A; De Negri, P; Eksborg, S; Ivani, G; Lönnqvist, PA, 2002) |
| " In the postoperative period the incidence of postoperative nausea and vomiting (PONV) (ND: n = 8, HD: n = 2, midazolam: n = 6) and the use of pritramid were lower in the clonidine HD group (HD: 38." | 5.10 | [Comparison of premedication with clonidine and midazolam combined with TCI for orthopaedic shoulder surgery]. ( Dietrich, PJ; Grottke, O; Krause, TH; Müller, J; Wappler, F, 2003) |
| " Our hypothesis is that coinduction with clonidine reduces the incidence of PONV in adult patients undergoing breast cancer surgery." | 5.10 | Effects of clonidine on postoperative nausea and vomiting in breast cancer surgery. ( Bergendahl, HT; Eksborg, S; Lönnqvist, PA; Muhrbeck, O; Oddby-Muhrbeck, E, 2002) |
| "This prospective, randomized, double-blinded study demonstrated that, when providing combined sciatic-femoral nerve block for hallux valgus repair, the addition of 1 microg/kg clonidine to 0." | 5.09 | Small-dose clonidine prolongs postoperative analgesia after sciatic-femoral nerve block with 0.75% ropivacaine for foot surgery. ( Aldegheri, G; Beccaria, P; Cappelleri, G; Casati, A; Fanelli, G; Magistris, L; Torri, G, 2000) |
| "This is a prospective randomized double-blind trial conducted to determine whether preoperative orally administered clonidine causes or potentiates postoperative vomiting in 140 children (3-12 yr) undergoing strabismus surgery." | 5.08 | Oral clonidine premedication reduces vomiting in children after strabismus surgery. ( Asano, M; Maekawa, N; Mikawa, K; Nishina, K; Obara, H, 1995) |
| "Randomised controlled trials, quasi-randomised controlled trials, and cluster trials comparing clonidine to placebo or no treatment, opioids, paracetamol, dexmedetomidine, or non-pharmacological pain-reducing interventions for the management of procedural pain, postoperative pain, and pain associated with clinical conditions in preterm and term newborns." | 5.05 | Clonidine for pain in non-ventilated infants. ( Bruschettini, M; Calevo, MG; Norman, E; Romantsik, O, 2020) |
| " Opioids are used in routinely, but alpha2-agonists, such as clonidine or cholinesterase inhibitors (neostigmine), have also been used for labour analgesia or to relieve pain following caesarean section." | 4.83 | The use of neuraxial adjuvant drugs (neostigmine, clonidine) in obstetrics. ( Roelants, F, 2006) |
| "To evaluate the duration and effect of superior hypogastric nerve block (SHNB) with ropivacaine and clonidine on postinterventional pain levels and opioid requirements in patients undergoing uterine artery embolization." | 4.31 | Postinterventional Patient Comfort After Uterine Artery Embolization and Superior Hypogastric Nerve Block. ( Binkert, CA; Najafi, A; Steffen, DA, 2023) |
| "The objective of this study was to determine whether postoperative morphine requirement in obese patients undergoing laparoscopic bariatric surgery was reduced by opioid-free anesthesia (OFA), as compared to an anesthetic strategy using opioids (opioid balanced anesthesia (OBA)) and to investigate the differences that may exist between the use of clonidine and dexmedetomidine in the context of OFA." | 4.12 | Effects of opioid-free anesthesia on postoperative morphine consumption after bariatric surgery. ( Abrard, S; Berlier, J; Bouffard, Y; Carabalona, JF; Cerro, V; Le-Goff, MC; Rimmelé, T; Subtil, F; Tête, H, 2022) |
| "We report the efficacy of perioperative infusion of clonidine and bupivacaine for above-knee amputation in a patient with a history of phantom limb pain in the same extremity after a previous below-knee amputation." | 3.74 | The efficacy of postoperative perineural infusion of bupivacaine and clonidine after lower extremity amputation in preventing phantom limb and stump pain. ( Adesioye, J; Madabhushi, L; Reuben, SS; Steinberg, RB, 2007) |
| "Clonidine can effectively reduce pain and/or hypersensitivity." | 3.74 | Effects of topical application of clonidine cream on pain behaviors and spinal Fos protein expression in rat models of neuropathic pain, postoperative pain, and inflammatory pain. ( Arita, H; Hanaoka, K; Hayashida, M; Li, C; Sawamura, S; Sekiyama, H; Sumida, T; Takeda, K; Yamada, Y, 2007) |
| "SpA facilitates postoperative pain management and is associated with faster mobilisation and shorter LOS." | 3.11 | Spinal anaesthesia with clonidine: pain relief and earlier mobilisation after open nephrectomy - a randomised clinical trial. ( Dahlin, BI; Hultin, M; Johansson, G; Ljungberg, B; Thurm, M; Winsö, O, 2022) |
| "The secondary endpoints were postoperative pain intensity, postoperative complications, patient satisfaction assessed using the QoR-40 questionnaire and the financial cost of anesthesia." | 3.11 | The efficacy and safety of an adapted opioid-free anesthesia regimen versus conventional general anesthesia in gynecological surgery for low-resource settings: a randomized pilot study. ( Bengono Bengono, RS; Metogo, JM; Minkande, JZ; Ndikontar, R; Ngouatna, S; Ntock, FN; Tochie, JN, 2022) |
| "Outcomes of interest included resting postoperative pain scores at 24 hours." | 3.01 | Comparative Efficacy of Adjuvant Nonopioid Analgesia in Adult Cardiac Surgical Patients: A Network Meta-Analysis. ( Ali, S; Deng, J; Heybati, K; Heybati, S; Hou, W; Krever, M; Lynn, MJ; Mughal, R; Ramakrishna, H; Tzanis, K; Zhou, F, 2023) |
| "The time until the numbness wore off was 37 vs 21 hours (mean difference = 16 hours, 95% CI = 8 to 23)." | 2.94 | Extended Perineural Analgesia After Hip and Knee Replacement When Buprenorphine-Clonidine-Dexamethasone Is Added to Bupivacaine: Preliminary Report from a Randomized Clinical Trial. ( Ezaru, CS; Gilbert, KL; Ibinson, JW; Mikolic, JM; Muluk, VS; Paiste, HJ; Piva, SR; Rakesh, HR; Ritter, ME; Williams, BA, 2020) |
| "Fentanyl consumption was lower in Group SC and Group SC + T than in Group C at time periods 0-4 and 4-8 h (p < 0." | 2.87 | Ultrasound-guided bilateral superficial cervical block and preemptive single-dose oral tizanidine for post-thyroidectomy pain: a randomized-controlled double-blind study. ( Ahiskalioglu, A; Alici, HA; Ari, MA; Celik, EC; Dostbil, A; Doymus, O; Karadeniz, E; Oral Ahiskalioglu, E; Sengoz, F; Yayik, AM, 2018) |
| "The primary outcome was acute postoperative pain." | 2.87 | Clonidine Effect on Pain After Cesarean Delivery: A Randomized Controlled Trial of Different Routes of Administration. ( Ashmawi, HA; Bliacheriene, F; Corregliano, GT; Fernandes, HS; Francisco, RP; Torres, ML; Vago, TM, 2018) |
| "The incidence of postoperative nausea in women was more than men (p=0." | 2.87 | Comparison of Ondansetron versus Clonidine efficacy for prevention of postoperative pain, nausea and vomiting after orthognathic surgeries: A triple blind randomized controlled trial. ( Eshghpour, M; Hashemipour, MS; Hosseini-Abrishami, M; Mianbandi, V; Samieirad, S; Shadkam, E; Sharifian-Attar, A, 2018) |
| "In clonidine groups, there was significant prolongation of motor and sensory block when compared to ropivacaine group alone." | 2.84 | Clonidine, but not Dexamethasone, Prolongs Ropivacaine-Induced Supraclavicular Brachial Plexus Nerve Block Duration. ( Alexander, J; Drummond, S; Gasanova, I; Hill, G; Howard, J; Melikman, E; Minhajuddin, A; Nasir, D; Ogunnaike, B; Whitten, C, 2017) |
| "Morphine has no additive effect and there is insufficient evidence on epinephrine and clonidine." | 2.82 | The Efficacy and Safety of Periarticular Injection in Total Joint Arthroplasty: A Direct Meta-Analysis. ( Casambre, FD; Della Valle, CJ; Fillingham, YA; Hamilton, WG; Hannon, CP; Kamath, AF; Karas, V; Nelson, N; Spangehl, MJ; Verity, TJ, 2022) |
| "Tizanidine is a centrally acting α2-agonist with muscle relaxant properties." | 2.82 | Tizanidine for the management of acute postoperative pain after inguinal hernia repair: A placebo-controlled double-blind trial. ( Akkaya, T; Caparlar, C; Kulaçoğlu, H; Mercan, U; Yazicioğlu, D, 2016) |
| "Clonidine is an α2-adrenoceptor agonist, which has analgesic properties." | 2.82 | Clonidine Does Not Reduce Pain or Opioid Consumption After Noncardiac Surgery. ( Ali Sakr Esa, W; Babazade, R; Devereaux, PJ; Gilron, I; Honar, H; Hutcherson, MT; Kurz, A; Naylor, AJ; Parlow, J; Salmasi, V; Sessler, DI; Turan, A; Zimmerman, NM, 2016) |
| "The purpose of this study was to evaluate comparatively, in women undergoing caesarean section under spinal anesthesia, the effectiveness of hyperbaric bupivacaine combined with 3 different adjuvants (fentanyl, clonidine, and dexmedtomidine) on quality of blockade and maternal and neonatal repercussions." | 2.80 | A Randomised Controlled Trial to Evaluate the Effectiveness of Intrathecal Bupivacaine Combined with Different Adjuvants (Fentanyl, Clonidine and Dexmedetomidine) in Caesarean Section. ( Huang, AJ; Li, AZ; Li, KZ; Li, Z; Qi, J; Shi, CX; Tian, M; Xin, DQ; Zhang, CY, 2015) |
| "The intraocular pressures were measured at regular intervals during the 6-months follow-up period." | 2.80 | Influence on intraocular pressure of anti-inflammatory treatments after selective laser trabeculoplasty. ( Anctil, JL; Champagne, S; Des Marchais, B; Goyette, A; Lajoie, C, 2015) |
| "PACU surveillance and postoperative pain therapy was standardized." | 2.79 | Supplemental single shot femoral nerve block for total hip arthroplasty: impact on early postoperative care, pain management and lung function. ( Schmitt, J; Steinfeldt, T; Wagner, G; Wiesmann, T; Wulf, H; Zoremba, M, 2014) |
| "Main outcome measures were postoperative pain, use of analgesics, blood pressure, and plasma clonidine concentration." | 2.79 | Clonidine as an adjuvant to prolong local analgesia in conventional scleral buckle surgery. ( Górniak, M; Mulder, VC; Proost, JH; Veckeneer, M; Wubbels, RJ, 2014) |
| "diclofenac and morphine on demand." | 2.78 | Postoperative analgesic effect of intravenous (i.v.) clonidine compared with clonidine administration in wound infiltration for open cholecystectomy. ( Bala, I; Bharti, N; Dontukurthy, S; Singh, G, 2013) |
| "Ninety adult trauma patients of American Society of Anesthesiologists physical status I-II, scheduled for lower limb surgery under subarachnoid block, were randomly allocated to one of three groups." | 2.78 | The analgesic effect of intrathecal dexmedetomidine or clonidine, with bupivacaine, in trauma patients undergoing lower limb surgery: a randomised, double-blind study. ( Batra, YK; Bharti, N; Jain, A; Kumar, P; Nikhar, SA; Solanki, SL, 2013) |
| "The frequency of neuropathic pain was assessed using the Douleur Neuropathique 4-question survey (DN4) in the first and second postoperative months." | 2.78 | Effect of the addition of clonidine to locally administered bupivacaine on acute and chronic postmastectomy pain. ( Abdel-Ghaffar, HS; Mohamed, SA, 2013) |
| "Duration of surgery, emergence time, postoperative pain score measured by the face, legs, activity, cry, consolability (FLACC) scale, postoperative analgesia time, and overall use of rescue analgesics were recorded." | 2.77 | Caudal bupivacaine supplemented with morphine or clonidine, or supplemented with morphine plus clonidine in children undergoing infra-umbilical urological and genital procedures: a prospective, randomized and double-blind study. ( Fernandes, ML; Gomez, RS; Pires, KC; Tibúrcio, MA, 2012) |
| "Propofol is a popular agent for providing intraoperative sedation in pediatric population during lumbar puncture and spinal anesthesia." | 2.76 | An evaluation of intrathecal bupivacaine combined with intrathecal or intravenous clonidine in children undergoing orthopedic surgery: a randomized double-blinded study. ( Cao, JP; Liu, J; Miao, XY; Shi, XY, 2011) |
| "Clonidine is an alpha(2) adrenoreceptor and imidazoline receptor agonist, which has analgesic, sedative, and minimum alveolar anesthetic concentration-sparing effects." | 2.74 | The analgesic effect of epidural clonidine after spinal surgery: a randomized placebo-controlled trial. ( Farmery, AD; Wilson-MacDonald, J, 2009) |
| "Hyperalgesia contributes to postoperative pain and may be associated with increased risk of chronic pain after surgery." | 2.73 | An evaluation of the postoperative antihyperalgesic and analgesic effects of intrathecal clonidine administered during elective cesarean delivery. ( Collet, V; De Kock, MF; Lavand'homme, PM; Roelants, F; Waterloos, H, 2008) |
| "The clonidine groups experienced less postoperative pain (P = 0." | 2.73 | Epidural clonidine for postoperative pain after total knee arthroplasty: a dose-response study. ( Huang, YS; Huh, BK; Lin, LC; Sheen, MJ; Wong, CS; Wu, CT; Yeh, CC, 2007) |
| " Patients received a single caudal dose of 2 mcg/kg of clonidine, 10 mcg/kg of hydromorphone, or 50 mcg/kg of morphine, combined with 1." | 2.73 | A comparison of single-dose caudal clonidine, morphine, or hydromorphone combined with ropivacaine in pediatric patients undergoing ureteral reimplantation. ( Carvallo, D; Johnson, JL; Mazurek, MS; Presson, RG; Vetter, TR, 2007) |
| "Sufentanil was given during the intraoperative period for a 20% increase in arterial mean pressure or heart rate in a patient with a bispectral index between 40 and 60." | 2.73 | Analgesic efficacy of bilateral superficial cervical plexus block administered before thyroid surgery under general anaesthesia. ( Amrouni, H; Andrieu, G; Carnaille, B; Lebuffe, G; Pattou, F; Robin, E; Vallet, B; Wattier, JM, 2007) |
| "The parameters of postoperative pain level using VAS score (visual analog scale), sedation and analgesics consumption were determined as outcome measures at 1, 2, 6, and 24 h of the operation." | 2.73 | Effects of clonidine preemptive analgesia on acute postoperative pain in abdominal surgery. ( Buković, D; Buković, N; Husedzinović, I; Pavelić, L; Persec, J; Persec, Z, 2007) |
| "Morphine dosage [median (25th-75th percentiles)] was less in the first 24 h in the patients who were given intrathecal morphine + clonidine [7 (0-37) mg] than in other patients [40." | 2.71 | Intrathecal morphine and clonidine for coronary artery bypass grafting. ( Arnulf, JJ; Balarac, N; Bonnet, F; Lena, P; Teboul, J, 2003) |
| "Clonidine has been shown to reduce perioperative circulatory instability." | 2.71 | Oral clonidine premedication preserves heart rate variability for patients undergoing larparoscopic cholecystectomy. ( Chan, KH; Hseu, SS; Teng, YH; Yien, HW; Yu, HP, 2003) |
| " We randomized 45 patients to 3 groups receiving intrathecal hyperbaric bupivacaine 6 mg combined with saline (Group B), clonidine 15 micro g (Group BC15), or clonidine 30 micro g (Group BC30); all solutions were diluted with saline to 3 mL." | 2.71 | Clonidine combined with small-dose bupivacaine during spinal anesthesia for inguinal herniorrhaphy: a randomized double-blinded study. ( Axelsson, K; Dobrydnjov, I; Gupta, A; Holmström, B; Klockhoff, H; Matthiesen, P; Thörn, SE, 2003) |
| "Clonidine has analgesic properties." | 2.71 | Transdermal clonidine: does it affect pain after abdominal hysterectomy? ( Dimou, P; Fassoulaki, A; Papilas, K; Paraskeva, A, 2003) |
| "The efficiency of bilateral paravertebral blockade combined with general anaesthesia (active) vs." | 2.71 | General anaesthesia combined with bilateral paravertebral blockade (T5-6) vs. general anaesthesia for laparoscopic cholecystectomy: a prospective, randomized clinical trial. ( Lönnqvist, PA; Naja, MZ; Ziade, MF, 2004) |
| "Clonidine has been shown to prolong sensory analgesia when given as an adjunct to peripheral nerve blocks but has not been evaluated when given in conjunction with a femoral-sciatic nerve block." | 2.71 | The addition of clonidine to bupivacaine in combined femoral-sciatic nerve block for anterior cruciate ligament reconstruction. ( Couture, DJ; Cuniff, HM; Maye, JP; Pellegrini, J, 2004) |
"We examined the dose-response relationship of intrathecal clonidine at small doses (| 2.71 | Small-dose intrathecal clonidine and isobaric bupivacaine for orthopedic surgery: a dose-response study. ( Aeschbach, A; Gurzeler, JA; Kindler, CH; Schneider, MC; Strebel, S, 2004) | |
| "The incidence of immediate postoperative pain (0-2 h), as assessed by repeated Objective Pain Scale (OPS) scores, was chosen as the primary end-point of the study." | 2.71 | Clonidine vs. midazolam as premedication in children undergoing adeno-tonsillectomy: a prospective, randomized, controlled clinical trial. ( Bergendahl, HT; Eksborg, S; Lönnqvist, PA; Nordenberg, L; Oddby, E; Ruthström, E; Zetterqvist, H, 2004) |
| "Mechanical hyperalgesia was measured by von Frey filaments." | 2.71 | The short-lasting analgesia and long-term antihyperalgesic effect of intrathecal clonidine in patients undergoing colonic surgery. ( De Kock, M; Lavand'homme, P; Waterloos, H, 2005) |
| "The need for postoperative pain medication was significantly lower in the clonidine group." | 2.71 | Comparison of clonidine and epinephrine in lidocaine anaesthesia for lower third molar surgery. ( Brkovic, B; Stojic, D; Todorovic, L, 2005) |
| "Clonidine is an alpha 2 adrenergic agonist with analgesic properties." | 2.70 | Comparison of morphine alone with morphine plus clonidine for postoperative patient-controlled analgesia. ( Hall, JE; Jeffs, SA; Morris, S, 2002) |
| "Midazolam was superior to clonidine as oral preanesthetic medication for these patients." | 2.70 | A comparison of oral clonidine and oral midazolam as preanesthetic medications in the pediatric tonsillectomy patient. ( Fazi, L; Jantzen, EC; Kurth, CD; Rose, JB; Watcha, MF, 2001) |
| "Four clonidine-treated patients required urapidil to achieve satisfactory hypotension as compared with 11 controls (P<0." | 2.70 | Clonidine decreases intraoperative bleeding in middle ear microsurgery. ( Delgado-Martinez, AD; Gómez-Luque, A; Marchal, JM; Martínez-López, MC; Martos-Crespo, F; Sánchez De La Cuesta, F, 2001) |
| " We investigated the dose-response relationship for epidural clonidine when added to a continuous postoperative epidural infusion of ropivacaine." | 2.70 | The dose-response relationship for clonidine added to a postoperative continuous epidural infusion of ropivacaine in children. ( De Negri, P; De Vivo, P; Ivani, G; Lonnqvist, PA; Visconti, C, 2001) |
| "This study evaluates the efficacy and side effects of a low dose of epidural morphine combined with clonidine for postoperative pain relief after lumbar disc surgery." | 2.70 | Epidural administration of low-dose morphine combined with clonidine for postoperative analgesia after lumbar disc surgery. ( Bonhomme, V; Brichant, JF; Dewandre, PY; Doll, A; Ghassempour, K; Hans, P, 2002) |
| " On the other hand, the bolus of intravenous clonidine 2 microg/kg (group C) was less effective in terms of pain relief but with similar side-effects to the 3 microg/kg dosage (group B)." | 2.70 | Clonidine for treatment of postoperative pain: a dose-finding study. ( Ciccozzi, A; Di Pietro, A; Donatelli, F; Iovinelli, G; Marinangeli, F; Paladini, A; Rawal, N; Varrassi, G, 2002) |
| "Oral clonidine is an effective analgesic and sedative for children undergoing tonsillectomy or adenotonsillectomy." | 2.69 | The effectiveness of clonidine as an analgesic in paediatric adenotonsillectomy. ( Dunn, GS; Merrick, PM; Montgomery, CJ; Reimer, EJ; Sanderson, PM; Scheepers, LD, 1998) |
| "Our results show that high doses of epidural clonidine potentiate general anesthetics and provide more efficient postoperative analgesia than the two bupivacaine dosage regimens investigated." | 2.69 | Epidural clonidine or bupivacaine as the sole analgesic agent during and after abdominal surgery: a comparative study. ( De Kock, M; Gautier, P; Jonniaux, M; Lavand'homme, P; Pavlopoulou, A, 1999) |
| "Clonidine has been added to local anesthetic regimens for various peripheral nerve blocks, resulting in prolonged anesthesia and analgesia." | 2.69 | Intravenous regional anesthesia using lidocaine and clonidine. ( Klatt, JL; Klatt, ML; Reuben, SS; Steinberg, RB, 1999) |
| "Sevoflurane was titrated against a BIS held between 40 and 50." | 2.69 | Influence of intravenous clonidine pretreatment on anesthetic requirements during bispectral EEG-guided sevoflurane anesthesia. ( Buyse, L; De Deyne, C; De Jongh, R; Deghislage, J; Heylen, R; Rolly, G; Struys, M; Van der Laenen, M, 2000) |
| "Clonidine 75 micrograms was added in group C and saline 1 ml in group S." | 2.69 | Caudal clonidine for postoperative analgesia in adults. ( Lebrun, T; Mehdaoui, H; Pastureau, F; Van Elstraete, AC, 2000) |
| "Bupivacaine consumption was significantly less in Groups 2 and 3 than in Group 1 (P < 0." | 2.69 | Extended "three-in-one" block after total knee arthroplasty: continuous versus patient-controlled techniques. ( Gouverneur, JM; Singelyn, FJ, 2000) |
| "To determine whether a low dose of spinal clonidine either alone or combined with sufentanil would provide effective analgesia following abdominal surgery, as a supplement to bupivacaine spinal anesthesia." | 2.69 | Low-dose intrathecal clonidine combined with sufentanil as analgesic drugs in abdominal gynecological surgery. ( Julião, MC; Lauretti, GR, 2000) |
| "Postoperative pain was assessed by a blinded observer using a modified objective pain scale (OPS)." | 2.69 | Diclofenac and flurbiprofen with or without clonidine for postoperative analgesia in children undergoing elective ophthalmological surgery. ( Maekawa, N; Mikawa, K; Nishina, K; Obara, H; Shiga, M; Takao, Y, 2000) |
| "Clonidine is an effective preanesthetic medication in children, providing a preoperative sedative effect." | 2.68 | Oral clonidine premedication reduces postoperative pain in children. ( Maekawa, N; Mikawa, K; Nishina, K; Obara, H, 1996) |
| "Postoperative pain was assessed using a modified objective pain score and analgesia was administered if this score exceeded 4." | 2.68 | Comparison of the effects of adrenaline, clonidine and ketamine on the duration of caudal analgesia produced by bupivacaine in children. ( Aldridge, LA; Cook, B; Doyle, E; Grubb, DJ, 1995) |
| "Postoperative pain was assessed in a double-blind fashion using a visual analogue scale (VAS) at 1, 2, 3, 6 and 24 h after the end of surgery." | 2.68 | Peripheral analgesic effect of intra-articular clonidine. ( Bonnet, F; Gentili, M; Juhel, A, 1996) |
| "Oral clonidine is a useful component to postoperative balanced analgesia as it decreases PCA morphine requirements and decreases the incidence of nausea and vomiting." | 2.68 | Oral clonidine reduces postoperative PCA morphine requirements. ( Beattie, S; Bhola, D; Chu, C; Forrest, J; Kolesar, R; Park, J, 1996) |
| " Epidural clonidine infused at 20 microg/h improves analgesia during coughing when combined with epidural bupivacaine-fentanyl in patients undergoing lower abdominal surgery but is associated with hemodynamic changes and increased vasopressor requirement." | 2.68 | Postoperative epidural infusion: a randomized, double-blind, dose-finding trial of clonidine in combination with bupivacaine and fentanyl. ( Evans, SF; Lim, W; Orlikowski, CE; Paech, MJ; Pavy, TJ, 1997) |
| "The quality of postoperative pain relief was assessed using Smiley's pain analogue scale." | 2.68 | Caudal clonidine and bupivacaine for combined epidural and general anaesthesia in children. ( Bach, A; Böhrer, H; Böttiger, BW; Martin, E; Motsch, J; Skoberne, T, 1997) |
| "We conclude that for elective inguinal hernia repair, postoperative analgesia obtained by bupivacaine wound infiltration was not improved by the addition of clonidine 150 micrograms." | 2.68 | Does the addition of clonidine affect duration of analgesia of bupivacaine wound infiltration in inguinal hernia surgery? ( Eckersall, S; Elliott, S; Fligelstone, L; Jothilingam, S, 1997) |
| "or ketoprofen 100 mg p." | 2.67 | Effects of intrathecal clonidine on duration of bupivacaine spinal anaesthesia, haemodynamics, and postoperative analgesia in patients undergoing knee arthroscopy. ( Niemi, L, 1994) |
| "Clonidine has been shown to be an effective postoperative analgesia when applied epidurally." | 2.67 | Prevention of phantom pain after major lower limb amputation by epidural infusion of diamorphine, clonidine and bupivacaine. ( Bradley, JW; Dark, CH; Jahangiri, M; Jayatunga, AP, 1994) |
| "Postoperative pain was managed with PCA delivering 2 mg morphine per request in group A, 1." | 2.67 | Intraoperative and postoperative analgesia using intravenous opioid, clonidine and lignocaine. ( De Kock, M; Lavandhomme, P; Scholtes, JL, 1994) |
| " Peak plasma fentanyl concentrations (Fmax) and the time to reach Cmax (Tmax) were comparable in the two groups (0." | 2.67 | Effect of epidural clonidine on analgesia and pharmacokinetics of epidural fentanyl in postoperative patients. ( Bonnet, F; Levron, JC; Pluskwa, F; Rostaing, S; Saada, M; Vodinh, J, 1991) |
| "Clonidine was found to attenuate the increase in VO2 and VCO2 associated with recovery from anaesthesia." | 2.67 | Clonidine decreases postoperative oxygen consumption in patients recovering from general anaesthesia. ( Bonnet, F; Delaunay, L; Duvaldestin, P, 1991) |
| "In an attempt to maintain stable levels of an alpha 2-adrenergic agonist throughout the perioperative period, two different oral-transdermal clonidine dosage regimens were administered according to a randomized, double-blind, placebo-controlled study in patients undergoing abdominal surgery." | 2.67 | Clinical efficacy of oral-transdermal clonidine combinations during the perioperative period. ( Duncan, SR; Jarvis, DJ; Maze, M; Segal, IS; White, PF, 1991) |
| "It is essential to find good postoperative pain control strategies that facilitate early mobility, early recovery, and early hospital discharge with minimal side effects on the mother and infant." | 2.66 | Strategies of analgesic treatment after cesarean delivery. Current state and new alternatives. ( Arroyo-Fernández, FJ; Calderón Seoane, JE; Torres Morera, LM, 2020) |
| "Clonidine has been reported to produce analgesia in humans in different painful conditions." | 2.66 | Epidural clonidine for treatment of postoperative pain after thoracotomy. A double-blind placebo-controlled study. ( Gordh, T, 1988) |
| "Clonidine has antiemetic and analgesic properties and thus may be used as premedication to reduce postoperative vomiting and pain." | 2.61 | Safety and efficacy of clonidine on postoperative vomiting and pain in pediatric ophthalmic surgery: A systematic review and meta-analysis. ( Bai, CH; Chen, C; Chu, KC; Hsu, CW; Hsu, YP; Huang, CJ, 2019) |
| " This review demonstrates that neuraxial clonidine enhances postoperative analgesia in women having Caesarean section with neuraxial anaesthesia, but this has to be balanced against increased maternal adverse effects." | 2.58 | The impact of neuraxial clonidine on postoperative analgesia and perioperative adverse effects in women having elective Caesarean section-a systematic review and meta-analysis. ( Allen, TK; Habib, AS; Klinger, RY; Mishriky, BM, 2018) |
| "Mechanistic approaches and multimodal analgesic techniques have been clearly demonstrated to be the most effective pain management strategy to improve outcomes." | 2.55 | Analgesia in the surgical intensive care unit. ( Brudney, CS; Ehieli, E; Pyati, S; Yalamuri, S, 2017) |
| "Clonidine is an alpha-2 adrenergic agonist which has sedative, anxiolytic and analgesic properties." | 2.50 | Clonidine premedication for postoperative analgesia in children. ( Cyna, AM; Knight, N; Lambert, P; Middleton, P, 2014) |
| "Recent awareness that chronic pain may occur after childbirth has prompted clinicians and researchers to investigate this topic." | 2.49 | Chronic pain after childbirth. ( Bollag, L; Landau, R; Ortner, C, 2013) |
| "Neostigmine and tramadol increase the probability for post-operative nausea or vomiting (PONV)." | 2.48 | Bayesian enhanced meta-analysis of post-operative analgesic efficacy of additives for caudal analgesia in children. ( Engelman, E; Marsala, C, 2012) |
| "Caudal block is a safe procedure commonly used for pediatric perioperative analgesia." | 2.48 | [Pediatric caudal anesthesia: importance and aspects of safety concerns]. ( Mauch, J; Weiss, M, 2012) |
| "There is considerable evidence that caudally administered clonidine in addition to local anesthetics provides extended duration of analgesia with a decreased incidence for analgesic rescue requirement and little adverse effects compared to caudal local anesthetics alone." | 2.47 | Efficacy and safety of clonidine as additive for caudal regional anesthesia: a quantitative systematic review of randomized controlled trials. ( Poepping, DM; Pogatzki-Zahn, EM; Schnabel, A; Zahn, PK, 2011) |
| "Current postoperative pain therapy revolves around the use of wound infiltration and systemic administration of opioids, nonsteroidal anti-inflammatory drugs and paracetamol." | 2.46 | Topical application of analgesics: a clinical option in day case anaesthesia? ( McCleane, G, 2010) |
| "Adjuvants are compounds which by themselves have undesirable side-effects or low potency but in combination with opioids allow a reduction of narcotic dosing for postoperative pain control." | 2.44 | Useful adjuvants for postoperative pain management. ( Buvanendran, A; Kroin, JS, 2007) |
| "The prevalences of complex regional pain syndrome, phantom limb pain, chronic donor-site pain, and persistent pain following total joint arthroplasty are alarmingly high." | 2.44 | Preventing the development of chronic pain after orthopaedic surgery with preventive multimodal analgesic techniques. ( Buvanendran, A; Reuben, SS, 2007) |
| "Clonidine is a mixed alpha (2)-/alpha (1)- adrenoceptor agonist." | 2.43 | [Efficacy of clonidine in paediatric anaesthesia]. ( Huber, D; Kretz, FJ, 2005) |
| "Clonidine has been used for many purposes, including reduction of blood pressure in hypertension, reduction in alcohol and drug withdrawal phenomena, reduction in nicotine withdrawal symptoms during smoking cessation, analgesia, reduction in stress response, and now as an anti-ischemic agent to reduce the risk of perioperative myocardial ischemia and perioperative mortality." | 2.43 | Clonidine and modification of perioperative outcome. ( Wallace, AW, 2006) |
| "Clonidine has shown considerable analgesic effect, with minimal adverse effects." | 2.42 | Non-narcotic adjuvants may improve the duration and quality of analgesia after knee arthroscopy: a brief review. ( Brill, S; Plaza, M, 2004) |
| "Clonidine is an alpha 2-adrenoceptor agonist which has been used for over 20 years to treat hypertension." | 2.40 | The role of clonidine in anaesthesia. ( Eltringham, R; Sanderson, PM, 1998) |
| "Clonidine is a selective alpha 2 adrenergic receptors agonist with a wide spectrum of activity." | 2.40 | [Use of clonidine for perioperative therapy]. ( Fidziańska-Długosz, E, 1998) |
| "Its use in premedication and postoperative pain management may be limited by its principal effects of hypotension and bradycardia." | 2.38 | [The role of clonidine in anesthesia]. ( Heil, T; Koenigs, D; Striebel, HW, 1993) |
| "Secondary outcomes included postoperative pain scores, requirement for postoperative morphine titration, total opioid analgesics consumption within the first 48 postoperative hours, incidence of nausea and vomiting, intraoperative haemodynamic." | 1.51 | Effect of opioid-free anaesthesia on postoperative epidural ropivacaine requirement after thoracic surgery: A retrospective unmatched case-control study. ( Bedon-Carte, S; Bello, M; Leo, F; Oger, S; Ouattara, A; Vielstadte, C; Zaouter, C, 2019) |
| "Median postoperative pain scores were, at rest and at mobilization respectively 3 [IQR 2-4] and 6 [IQR 4." | 1.48 | Pain management in living related adult donor hepatectomy: feasibility of an evidence-based protocol in 100 consecutive donors. ( De Kock, M; Dewe, G; Forget, P; Lois, F; Reding, R; Steyaert, A, 2018) |
| "Breast cancer is the most common cancer in women, and mastectomy is commonly performed as part of the management." | 1.43 | The effect of serratus plane block performed under direct vision on postoperative pain in breast surgery. ( Babar, M; Davies, G; Harada, A; Hards, M; Harwell, S; Neville, I; Ravalia, A, 2016) |
| "Clonidine is a useful analgesic-sedative agent; however, few data exist regarding its use in infants after congenital heart disease surgery." | 1.40 | Enteral absorption and haemodynamic response of clonidine in infants post-cardiac surgery. ( Arenas-Lopez, S; Durward, A; Manna, S; Mulla, H; Murdoch, IA; Tibby, SM, 2014) |
| "The adenosinergic system was assessed by systemic (intraperitoneal), central (intrathecal), and peripheral (intraplantar) administration of caffeine." | 1.39 | Ankle joint mobilization affects postoperative pain through peripheral and central adenosine A1 receptors. ( Cidral-Filho, FJ; Martins, DF; Mazzardo-Martins, L; Santos, AR; Stramosk, J, 2013) |
| "The clonidine group had lower VPS at rest (2." | 1.37 | A prospective survey of patient-controlled epidural analgesia with bupivacaine and clonidine after total hip replacement: a pre- and postchange comparison with bupivacaine and hydromorphone in 1,000 patients. ( Bae, JJ; Bieltz, M; Liu, SS; Ma, Y; Wukovits, B, 2011) |
| "The present study compares postoperative pain scores in male and female rats and how they respond to analgesic interventions." | 1.32 | Postoperative pain and analgesic responses are similar in male and female Sprague-Dawley rats. ( Buvanendran, A; Kroin, JS; Nagalla, SK; Tuman, KJ, 2003) |
| "Morphine consumption was recorded for the following 24 h as were visual analog pain scores and the degree of sensory and motor blockade." | 1.31 | The efficacy and safety of epidural infusions of levobupivacaine with and without clonidine for postoperative pain relief in patients undergoing total hip replacement. ( Connolly, D; Convery, PN; Milligan, KR; Quinn, P; Weir, P, 2000) |
| "Tizanidine was given systemically to rats with experimental postoperative pain." | 1.31 | Systemic tizanidine hydrochloride (Zanaflex) partially decreases experimental postoperative pain in rats. ( Azevedo, MI; Denson, DD; Hord, AH, 2001) |
| "The use of opioids for postoperative pain relief is associated with the occurrence of side effects whatever the technique of administration." | 1.29 | [How can we improve the efficacy of morphine analgesia without increasing adverse effects?]. ( Bonnet, F; Vésinet, C, 1994) |
| "Two cases are reported of patients with phantom limb pain after lower limb amputation and requiring surgery of their stump." | 1.29 | [Temporary relief from pain in the phantom limb after spinal anesthesia using a combination of bupivacaine and clonidine]. ( Bonnet, F; Gentili, ME, 1993) |
| "Clonidine was instilled into the pleural space at the end of the operation via a silastic catheter placed through the seventh intercostal space." | 1.29 | The use of intrapleural clonidine for postoperative pain control. ( Canver, CC; Pilli, G, 1996) |
| " Plasma elimination half-life was 829 +/- 157 min and plasma clearance was 177 +/- 28 ml min-1." | 1.28 | Pharmacokinetics of clonidine after epidural administration in surgical patients. Lack of correlation between plasma concentration and analgesia and blood pressure changes. ( Bovill, JG; Houben, JJ; Ploeger, EJ; van Essen, EJ, 1992) |
| "Clonidine was absorbed in a dose-dependent manner into the systemic circulation, with plasma concentrations 0." | 1.28 | Epidural clonidine analgesia following surgery: phase I. ( Eisenach, JC; Lysak, SZ; Viscomi, CM, 1989) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 11 (3.01) | 18.7374 |
| 1990's | 98 (26.78) | 18.2507 |
| 2000's | 141 (38.52) | 29.6817 |
| 2010's | 97 (26.50) | 24.3611 |
| 2020's | 19 (5.19) | 2.80 |
| Authors | Studies |
|---|---|
| Williams, BA | 5 |
| Ibinson, JW | 4 |
| Mikolic, JM | 2 |
| Boudreaux-Kelly, MY | 1 |
| Paiste, HJ | 2 |
| Gilbert, KL | 2 |
| Bonant, SA | 1 |
| Ritter, ME | 2 |
| Ezaru, CS | 2 |
| Muluk, VS | 2 |
| Piva, SR | 2 |
| Mysore, V | 1 |
| Muniswamy, S | 1 |
| Chathra, N | 1 |
| Venkataram, J | 1 |
| Berlier, J | 1 |
| Carabalona, JF | 1 |
| Tête, H | 1 |
| Bouffard, Y | 1 |
| Le-Goff, MC | 1 |
| Cerro, V | 1 |
| Abrard, S | 1 |
| Subtil, F | 1 |
| Rimmelé, T | 1 |
| Hannon, CP | 1 |
| Fillingham, YA | 1 |
| Spangehl, MJ | 1 |
| Karas, V | 1 |
| Kamath, AF | 1 |
| Casambre, FD | 1 |
| Verity, TJ | 1 |
| Nelson, N | 1 |
| Hamilton, WG | 1 |
| Della Valle, CJ | 1 |
| Thurm, M | 2 |
| Hultin, M | 1 |
| Johansson, G | 1 |
| Dahlin, BI | 1 |
| Winsö, O | 2 |
| Ljungberg, B | 2 |
| Tochie, JN | 1 |
| Bengono Bengono, RS | 1 |
| Metogo, JM | 1 |
| Ndikontar, R | 1 |
| Ngouatna, S | 1 |
| Ntock, FN | 1 |
| Minkande, JZ | 1 |
| Steffen, DA | 1 |
| Najafi, A | 1 |
| Binkert, CA | 1 |
| Heybati, K | 1 |
| Zhou, F | 1 |
| Lynn, MJ | 1 |
| Deng, J | 1 |
| Ali, S | 1 |
| Hou, W | 1 |
| Heybati, S | 1 |
| Tzanis, K | 1 |
| Krever, M | 1 |
| Mughal, R | 1 |
| Ramakrishna, H | 1 |
| Bhenderu, LS | 1 |
| Lyon, KA | 1 |
| Soto, JM | 1 |
| Richardson, W | 1 |
| Desai, R | 1 |
| Rahm, M | 1 |
| Huang, JH | 1 |
| Maharani, ND | 1 |
| Fuadi, A | 1 |
| Halimi, RA | 1 |
| Choudhry, DK | 2 |
| Brenn, BR | 2 |
| Sacks, K | 2 |
| Shah, S | 1 |
| Evans, KM | 1 |
| Breidenstein, MW | 1 |
| Pedro, C | 1 |
| Nunez, K | 1 |
| Marroquin, B | 1 |
| Grondin, LS | 1 |
| Arroyo-Fernández, FJ | 1 |
| Calderón Seoane, JE | 1 |
| Torres Morera, LM | 1 |
| Romantsik, O | 1 |
| Calevo, MG | 2 |
| Norman, E | 1 |
| Bruschettini, M | 1 |
| Charvin, M | 1 |
| Longeras, F | 1 |
| Jouve, P | 1 |
| Cherprenet, AL | 1 |
| Futier, E | 1 |
| Pereira, B | 1 |
| Dualé, C | 1 |
| Rakesh, HR | 1 |
| Barbero, GE | 1 |
| de Miguel, M | 1 |
| Sierra, P | 1 |
| Merritt, G | 1 |
| Bora, P | 1 |
| Borah, N | 1 |
| Ciarallo, C | 1 |
| Ing, R | 1 |
| Bosenberg, A | 1 |
| de Nadal, M | 1 |
| Mostafa, MF | 1 |
| Hamed, E | 1 |
| Amin, AH | 1 |
| Herdan, R | 1 |
| Visoiu, M | 1 |
| Scholz, S | 1 |
| Malek, MM | 1 |
| Carullo, PC | 1 |
| Michot, T | 1 |
| Duysinx, P | 1 |
| Belle, F | 1 |
| Dresse, C | 1 |
| Montupil, J | 1 |
| Bonhomme, V | 2 |
| Defresne, A | 1 |
| Carvalho, F | 1 |
| Sanchez Munoz, MC | 1 |
| De Kock, M | 8 |
| Forget, P | 2 |
| Kröger Dahlin, BI | 1 |
| Nasir, D | 1 |
| Gasanova, I | 1 |
| Drummond, S | 1 |
| Alexander, J | 1 |
| Howard, J | 1 |
| Melikman, E | 1 |
| Hill, G | 1 |
| Minhajuddin, A | 1 |
| Ogunnaike, B | 1 |
| Whitten, C | 1 |
| Abdel Hay, J | 1 |
| Kobaiter-Maarrawi, S | 1 |
| Tabet, P | 1 |
| Moussa, R | 1 |
| Rizk, T | 1 |
| Nohra, G | 1 |
| Okais, N | 1 |
| Samaha, E | 1 |
| Maarrawi, J | 2 |
| Allen, TK | 1 |
| Mishriky, BM | 1 |
| Klinger, RY | 1 |
| Habib, AS | 1 |
| Ahiskalioglu, A | 1 |
| Yayik, AM | 1 |
| Oral Ahiskalioglu, E | 1 |
| Dostbil, A | 1 |
| Doymus, O | 1 |
| Karadeniz, E | 1 |
| Ari, MA | 1 |
| Sengoz, F | 1 |
| Alici, HA | 1 |
| Celik, EC | 1 |
| Hoyt, MR | 1 |
| Shah, U | 1 |
| Cooley, J | 1 |
| Temple, M | 1 |
| Fernandes, HS | 1 |
| Bliacheriene, F | 1 |
| Vago, TM | 1 |
| Corregliano, GT | 1 |
| Torres, ML | 1 |
| Francisco, RP | 1 |
| Ashmawi, HA | 1 |
| Danoff, JR | 1 |
| Goel, R | 1 |
| Henderson, RA | 1 |
| Fraser, J | 1 |
| Sharkey, PF | 1 |
| Kendall, MC | 1 |
| Castro-Alves, LJ | 1 |
| Hay, JA | 1 |
| Maranto, CJ | 1 |
| Strickland, NR | 1 |
| Goree, JH | 1 |
| Turner, JD | 1 |
| Dobson, SW | 1 |
| Henshaw, DS | 1 |
| Edwards, CJ | 1 |
| Weller, RS | 1 |
| Reynolds, JW | 1 |
| Russell, GB | 1 |
| Jaffe, JD | 1 |
| Samieirad, S | 1 |
| Sharifian-Attar, A | 1 |
| Eshghpour, M | 1 |
| Mianbandi, V | 1 |
| Shadkam, E | 1 |
| Hosseini-Abrishami, M | 1 |
| Hashemipour, MS | 1 |
| Dewe, G | 1 |
| Steyaert, A | 1 |
| Lois, F | 1 |
| Reding, R | 1 |
| Haydar, B | 1 |
| Holman, A | 1 |
| Galante, D | 1 |
| Bello, M | 1 |
| Oger, S | 1 |
| Bedon-Carte, S | 1 |
| Vielstadte, C | 1 |
| Leo, F | 1 |
| Zaouter, C | 1 |
| Ouattara, A | 1 |
| Bailey, L | 1 |
| Griffin, J | 1 |
| Elliott, M | 1 |
| Wu, J | 1 |
| Papavasiliou, T | 1 |
| Harner, C | 1 |
| Lowe, W | 1 |
| Vittinghoff, M | 1 |
| Lönnqvist, PA | 8 |
| Morton, NS | 1 |
| Kjølhede, P | 1 |
| Bergdahl, O | 1 |
| Borendal Wodlin, N | 1 |
| Nilsson, L | 1 |
| Dereu, D | 1 |
| Savoldelli, GL | 1 |
| Mercier, Y | 1 |
| Combescure, C | 1 |
| Mathivon, S | 1 |
| Rehberg, B | 1 |
| Dang, DY | 1 |
| McGarry, SM | 1 |
| Melbihess, EJ | 1 |
| Haytmanek, CT | 1 |
| Stith, AT | 1 |
| Griffin, MJ | 1 |
| Ackerman, KJ | 1 |
| Hirose, CB | 1 |
| Hsu, YP | 1 |
| Chu, KC | 1 |
| Bai, CH | 1 |
| Huang, CJ | 1 |
| Chen, C | 1 |
| Hsu, CW | 1 |
| Landau, R | 1 |
| Bollag, L | 1 |
| Ortner, C | 1 |
| Kelley, TC | 1 |
| Adams, MJ | 1 |
| Mulliken, BD | 1 |
| Dalury, DF | 1 |
| Naja, ZM | 1 |
| Ziade, FM | 1 |
| El-Rajab, MA | 1 |
| Naccash, N | 1 |
| Ayoubi, JM | 1 |
| Bharti, N | 2 |
| Dontukurthy, S | 1 |
| Bala, I | 1 |
| Singh, G | 1 |
| Nitta, R | 1 |
| Goyagi, T | 2 |
| Nishikawa, T | 4 |
| Wiesmann, T | 1 |
| Steinfeldt, T | 1 |
| Wagner, G | 1 |
| Wulf, H | 1 |
| Schmitt, J | 1 |
| Zoremba, M | 1 |
| Sun, R | 1 |
| Zhao, W | 1 |
| Hao, Q | 1 |
| Tian, H | 1 |
| Tian, J | 1 |
| Li, L | 1 |
| Jia, W | 1 |
| Yang, K | 1 |
| Lambert, P | 1 |
| Cyna, AM | 1 |
| Knight, N | 1 |
| Middleton, P | 1 |
| Baptista, JF | 1 |
| Gomez, RS | 2 |
| Paulo, DN | 1 |
| Carraretto, AR | 1 |
| Brocco, MC | 1 |
| Silva, JJ | 1 |
| Arenas-Lopez, S | 1 |
| Mulla, H | 1 |
| Manna, S | 1 |
| Durward, A | 1 |
| Murdoch, IA | 1 |
| Tibby, SM | 1 |
| Górniak, M | 1 |
| Proost, JH | 1 |
| Veckeneer, M | 1 |
| Mulder, VC | 1 |
| Wubbels, RJ | 1 |
| Mangione, MP | 2 |
| Scanlan, RL | 1 |
| Cohen, PZ | 2 |
| Modrak, RT | 1 |
| Tonarelli, EJ | 1 |
| Rakesh, H | 1 |
| Kmatz, AM | 1 |
| Li, Z | 1 |
| Tian, M | 1 |
| Zhang, CY | 1 |
| Li, AZ | 1 |
| Huang, AJ | 1 |
| Shi, CX | 1 |
| Xin, DQ | 1 |
| Qi, J | 1 |
| Li, KZ | 1 |
| Rubod, C | 1 |
| Hanssens, S | 1 |
| Lucot, JP | 1 |
| Pougeoise, MM | 1 |
| Devos, P | 1 |
| Dalmas, AF | 1 |
| Jules-Elysee, KM | 2 |
| Goon, AK | 2 |
| Westrich, GH | 1 |
| Padgett, DE | 1 |
| Mayman, DJ | 1 |
| Ranawat, AS | 1 |
| Ranawat, CS | 1 |
| Lin, Y | 2 |
| Kahn, RL | 2 |
| Bhagat, DD | 1 |
| Goytizolo, EA | 2 |
| Ma, Y | 2 |
| Reid, SC | 1 |
| Curren, J | 1 |
| YaDeau, JT | 3 |
| Champagne, S | 1 |
| Anctil, JL | 1 |
| Goyette, A | 1 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| 4-drug Nerve Block Versus Plain Local Anesthetic for Knee and Hip Arthroplasty Analgesia in Veterans[NCT02891798] | Phase 3 | 98 participants (Actual) | Interventional | 2016-10-31 | Completed | ||
| Randomized Study of Spinal Anesthesia Compared With Traditional Epidural Anesthesia Concerning Peroperative and Postoperative Pain After Open Nephrectomy in Patients With Renal Cell Carcinoma[NCT02030717] | Phase 2/Phase 3 | 120 participants (Actual) | Interventional | 2012-02-29 | Completed | ||
| General Anesthesia Usiing Fentanyl Plus Propofol Plus Rococuronium Plus Isoflurane Versus Ketamime Plus Magnesium Sulphate Plus Lidocaine Plus Clonidine Plus Propofol Plus Rococuronium Plus Isoflurane in Gynaecology Surgery[NCT04737473] | 36 participants (Anticipated) | Interventional | 2020-01-06 | Recruiting | |||
| Interest of a Bi-truncal Nerve Block (Femoral + Sciatic) Extended, Systematically Associated With General Anesthesia, in the Femoropopliteal Bypass: Study of Post-operative Analgesia and Peripheral Circulation Downstream.[NCT01785693] | Phase 4 | 47 participants (Actual) | Interventional | 2013-01-30 | Completed | ||
| Dexmedetomidine Versus Clonidine Adjuvants to Levobupivacaine for Transversus Abdominis Plane Block in Pediatric Laparoscopic Orcheopexy: Randomized Double-blind Study[NCT03155646] | Phase 2/Phase 3 | 90 participants (Actual) | Interventional | 2017-06-10 | Completed | ||
| ROPIVACAINE WITH CLONIDINE FOR PEDIATRIC RECTUS SHEATH BLOCKS- THE MAGIC COMBINATION? - A Double Blinded Prospective Study[NCT02439281] | 50 participants (Actual) | Interventional | 2015-05-31 | Terminated (stopped due to The patients were discharged on the day of the surgery.) | |||
| Randomized Double-blind Trial Comparing the Post-operative Analgesic Efficacy of Local Wound Infiltration With Bupivacaine Alone to Bupivacaine With Clonidine in Posterior Spine Surgeries[NCT01902108] | Phase 4 | 225 participants (Actual) | Interventional | 2013-01-31 | Completed | ||
| Preemptive Single Dose Tizanidine and Ultrasound Guided Superficial Cervical Block on Pain After Thyroidectomy[NCT02725359] | Phase 4 | 60 participants (Actual) | Interventional | 2016-04-30 | Completed | ||
| Comparison Between Intravenous and Intrathecal Clonidine in Post-cesarean Analgesia[NCT02550444] | 64 participants (Actual) | Interventional | 2015-04-30 | Completed | |||
| Comparison of PECS II Block and Combined Serratus Anterior Plane Block to Reduce Acute Pain After Mastectomy[NCT05961735] | 60 participants (Anticipated) | Observational | 2023-08-01 | Not yet recruiting | |||
| "Continuous Thoracic Epidural Analgesia Versus Continuous Erector Spinae Plane Block for Postoperative Analgesia in Patients Undergoing Adult Living Donar Open Hepatectomies."[NCT04151511] | 60 participants (Anticipated) | Interventional | 2019-10-19 | Recruiting | |||
| Ultrasound-guided Bilateral Erector Spinalis Plane Block on Postoperative Pain Management in Liver Transplantation Donors[NCT05406388] | 41 participants (Actual) | Interventional | 2020-12-24 | Completed | |||
| The Efficacy and Safety of Opioid-free Anesthesia(OFA) for Non-small-cell Lung Cancer Resection and Its Underlying Clinical Value: a Prospective Study[NCT05063396] | 60 participants (Anticipated) | Interventional | 2021-10-01 | Recruiting | |||
| Clinical Outcome Following Arthroscopic Knee Surgery (COFAKS)-Addendum[NCT03704376] | Phase 4 | 125 participants (Actual) | Interventional | 2016-02-01 | Completed | ||
| Will Intrathecal Analgesia Contribute to a Faster Recovery Compared With Epidural Analgesia After Open Surgery for Gynecological Cancer. An Open Controlled Randomized Study.[NCT02026687] | Phase 4 | 80 participants (Actual) | Interventional | 2014-03-31 | Completed | ||
| Transversus Abdominis Plane (TAP) Block Versus Intrathecal Morphine for Caesarean Section - Randomised Controlled Trial[NCT01931215] | Phase 4 | 180 participants (Actual) | Interventional | 2013-09-30 | Completed | ||
| A Prospective, Randomized Trial Evaluating Regional Anesthesia, Long-Acting Local Anesthesia, and Traditional Care for Pain Control of Operatively Treated Ankle Fractures[NCT03696199] | Phase 4 | 70 participants (Anticipated) | Interventional | 2020-09-01 | Recruiting | ||
| KINCISE™ Surgical Automated System in Total Hip Arthroplasty (THA)[NCT05223777] | 50 participants (Anticipated) | Interventional | 2021-09-09 | Recruiting | |||
| A Safe Ketamine-Based Therapy for Treatment Resistant Depression[NCT01179009] | 20 participants (Actual) | Interventional | 2012-04-30 | Completed | |||
| Comparison of Intra-articular Dexmedetomidine and Magnesium in Postoperative Pain[NCT03479216] | Phase 4 | 62 participants (Actual) | Interventional | 2018-03-26 | Completed | ||
| Clonidine for Tourniquet-related Pain in Children: A Pilot Study[NCT04564430] | Phase 4 | 20 participants (Anticipated) | Interventional | 2021-03-01 | Recruiting | ||
| IV vs. Oral Acetaminophen as a Component of Multimodal Analgesia After Total Hip Arthroplasty: a Randomized, Blinded Trial[NCT03020966] | Phase 4 | 154 participants (Actual) | Interventional | 2017-02-16 | Completed | ||
| The Value of Adding Either Meperdine or Fentanyl to Clonidine-bupivacaine Mixture in Patients With Lower Limb Orthopedic Surgery Using Combined Spinal Epidural Anesthesia[NCT02128451] | Phase 4 | 90 participants (Actual) | Interventional | 2014-04-30 | Completed | ||
| Investigation of the Effectiveness of Tizanidine on Pain After Herniorrhaphy[NCT02016443] | Phase 4 | 30 participants (Actual) | Interventional | 2013-11-30 | Completed | ||
| Analgesic Duration of Interscalene Block After Outpatient Arthroscopic Shoulder Surgery With Intravenous Dexamethasone, Dexmedetomidine or Their Combination: A Randomized Controlled Trial[NCT03270033] | Phase 4 | 198 participants (Actual) | Interventional | 2017-09-18 | Completed | ||
| Opioid-Free Shoulder Arthroplasty[NCT03540030] | Phase 4 | 86 participants (Actual) | Interventional | 2016-09-30 | Completed | ||
| Natural History of Pain After Shoulder Arthroplasty Conducted With Multimodal Analgesia[NCT03021096] | 108 participants (Actual) | Observational | 2017-01-27 | Completed | |||
| Clinical Outcomes of an Adductor Canal Block Versus Liposomal Bupivacaine in Total Knee Arthroplasty Patients: A Randomized Prospective Study[NCT04086186] | Phase 4 | 60 participants (Actual) | Interventional | 2017-03-22 | Completed | ||
| Efficacy of Dexmedetomidine Versus Morphine as an Adjunct to Bupivacaine in Caudal Anesthesia for Pediatric Thoracic Surgeries. A Randomized Controlled Trial.[NCT04445636] | 50 participants (Actual) | Interventional | 2020-06-28 | Completed | |||
| A Comparative Study for Evaluation of the Analgesic Profile of Ultrasound-Guided Modified Pectoral Nerves Block Versus Serratus Plane Block in Major Breast Cancer Surgery[NCT02946294] | Phase 2 | 90 participants (Actual) | Interventional | 2016-10-31 | Completed | ||
| Randomized, Controlled Trial of Post-operative Steroids and Pain Control After Tonsillectomy[NCT03995628] | Phase 2 | 150 participants (Anticipated) | Interventional | 2018-12-18 | Recruiting | ||
| Transversus Abdominis Plane (TAP) Block for Cesarean Section[NCT01015807] | 90 participants (Actual) | Interventional | 2009-11-30 | Completed | |||
| SurgerySMART: Studying Melatonin and Recovery in Teens[NCT06093477] | 40 participants (Anticipated) | Interventional | 2024-07-31 | Not yet recruiting | |||
| Effects of Perioperative Melatonin on Sleep, Pain, and Confusion After Joint Replacement Surgery[NCT01505465] | 50 participants (Actual) | Interventional | 2012-02-29 | Completed | |||
| Comparison of Caudal Bupivacaine Alone With Bupivacaine Plus Two Doses of Dexmedetomidine for Postoperative Analgesia in Pediatric Patients Undergoing Infra-umbilical Surgery: A Randomized Controlled Double Blinded Study[NCT02385435] | Phase 2/Phase 3 | 91 participants (Actual) | Interventional | 2014-01-31 | Completed | ||
| Ultrasound-guided Block of the Supraclavicular Nerves for Clavicular Fractures in the Emergency Department[NCT04685291] | 42 participants (Actual) | Interventional | 2021-04-15 | Completed | |||
| Single-Shot With Dexmedetomidine Versus Continuous Ultrasound-guided Erector Spinae Plane Block for Postoperative Pain Control After Percutaneous Nephrolithotomy Prospective Randomized Clinical Trial[NCT04650737] | 40 participants (Anticipated) | Interventional | 2020-12-01 | Not yet recruiting | |||
| Interest in Clonidine in Association With Levobupivacaine Performing a Pudendal Block in Proctological Surgery: Pilot Study, Prospective[NCT04530903] | Phase 4 | 30 participants (Anticipated) | Interventional | 2020-09-09 | Recruiting | ||
| Effect of Verapamil as an Adjuvant to Bupivacaine in Supraclavicular Brachial Plexus Block Guided by Ultrasound for Forearm and Hand Surgeries[NCT05183997] | 60 participants (Anticipated) | Interventional | 2022-01-31 | Not yet recruiting | |||
| Use of Caudal Anesthesia Supplemented With Morphine in Children Undergoing Renal Surgery - Prospective Study[NCT01869036] | Phase 4 | 40 participants (Actual) | Interventional | 2012-07-31 | Completed | ||
| Pediatric Tonsillectomy Pain Reduction Study, a Randomized, Placebo Controlled, Double-Blind Clinical Trial Using Clonidine and Local Anesthetics[NCT00678379] | Phase 3 | 120 participants (Actual) | Interventional | 2008-04-30 | Completed | ||
| Association of Different Doses of Clonidine in Caudal Epidural Anesthesia for Hypospadias Surgery[NCT02769390] | Phase 2 | 80 participants (Actual) | Interventional | 2015-07-31 | Completed | ||
| A Prospective Study Comparing Total Intravenous Anesthesia With Propofol and Remifentanil vs. Propofol and Dexmedetomidine in Adolescent Idiopathic Scoliosis Patients Undergoing Posterior Spinal Fusion and Instrumentation[NCT06096181] | Phase 2 | 120 participants (Anticipated) | Interventional | 2023-12-31 | Not yet recruiting | ||
| Intravenous Lidocaine and Time to Regression of the Sensory Block After Spinal Anesthesia With Isobaric Bupivacaine in Patients Undergoing Surgery to Treat Skin and Soft Tissue Tumors of the Lower Limbs[NCT04741880] | Phase 2/Phase 3 | 66 participants (Anticipated) | Interventional | 2021-06-17 | Recruiting | ||
| Guanfacine for PONV and Pain After Sinus Surgery[NCT02882854] | 84 participants (Actual) | Interventional | 2016-11-30 | Completed | |||
| A Comparison of Morphine and Morphine Plus Dexmedetomidine in Chronic Cancer Pain[NCT02289261] | Phase 4 | 40 participants (Actual) | Interventional | 2014-11-30 | Completed | ||
| A Prospective Triple-masked Randomized Controlled Trial Measuring Analgesia Duration of Dexamethasone, Buprenorphine, or Clonidine With Ropivacaine for Interscalene Nerve Block[NCT03117140] | Phase 4 | 160 participants (Actual) | Interventional | 2013-12-31 | Completed | ||
| Dexmedetomidine Comme Adjuvant à la rachianesthésie Lors de césariennes électives : Une étude Pilote[NCT05099055] | Phase 3 | 42 participants (Actual) | Interventional | 2022-03-15 | Completed | ||
| ENDOblock: Do Bilateral Superficial Cervical Blocks With Local Wound Infiltration Decrease Postoperative Pain After Thyroid Surgery[NCT05805423] | 74 participants (Anticipated) | Interventional | 2023-04-17 | Recruiting | |||
| Caudal Epidural With Non Opioid Adjuvants in Lumbosacral Spine Surgery[NCT04411329] | 60 participants (Actual) | Interventional | 2020-06-06 | Completed | |||
| Effects of Clonidine and Midazolam Premedication on Bispectral Index and Recovery After Elective Surgery[NCT00638729] | 60 participants (Actual) | Interventional | 2005-08-31 | Completed | |||
| Effects of Addition of Systemic Tramadol or Adjunct Tramadol to Lidocaine Used for Intravenous Regional Anesthesia in Patients Undergoing Hand Surgery[NCT02658721] | Phase 3 | 60 participants (Actual) | Interventional | 2013-01-31 | Completed | ||
| Hemodynamic Effect of Intrathecal Clonidine in Hypertensive Subjects: A Pilot Study to Assess Its Effectiveness in Hypertensive Subjects With Poor Blood Pressure Control (Phase II)[NCT01297335] | Phase 2 | 10 participants (Actual) | Interventional | 2011-02-28 | Completed | ||
| Great Auricular Nerve Block for Children Undergoing Tympanomastoid Surgery: Does the Addition of Clonidine Increase the Duration of Postoperative Analgesia?[NCT01638052] | Phase 2 | 56 participants (Actual) | Interventional | 2006-02-28 | Completed | ||
| Transversus Abdominis Plane Block Versus Caudal Epidural for Lower Abdominal Surgery in Children: A Double-Blinded Randomized Controlled Trial[NCT02160821] | Phase 4 | 45 participants (Actual) | Interventional | 2011-01-31 | Completed | ||
| Prospective, Randomized, Double-Blinded, Allocation Concealed Study Comparing the Efficacy of Liposomal Bupivacaine Over Standard Bupivacaine Plus Dexamethasone in Quadriceps Sparing Femoral Nerve Block and Wound Infiltration for Primary Total Knee Arthro[NCT02624856] | Phase 4 | 0 participants (Actual) | Interventional | 2015-11-30 | Withdrawn (stopped due to Lack of funding) | ||
| Comparison of Clonidine and Morphine Plus Bupivacaine in Caudal Peridural Anesthesia for Postoperative Analgesia After Pediatric Urogenital Surgery[NCT00672347] | Phase 1/Phase 2 | 80 participants (Actual) | Interventional | 2008-07-31 | Completed | ||
| High Thoracic Epidural Anesthesia and Postoperative Analgesia With Ropivacaine or Levobupivacaine for Coronary Surgery: A Prospective Randomized Double-Blind Comparison[NCT00552864] | Phase 4 | 61 participants (Actual) | Interventional | 2003-01-31 | Completed | ||
| Sciatic Peripheral Nerve Blockade for Pain Control Following Hamstring Autograft Harvest in Adolescents: A Comparison of Two Techniques[NCT02947633] | 140 participants (Anticipated) | Interventional | 2015-03-31 | Enrolling by invitation | |||
| A Prospective, Randomized Trial of Liposomal Bupivacaine Compared to Continuous Nerve Catheters on Pain Control and Post-Operative Opioid Use in Receiving Popliteal Nerve Blocks for Below the Knee Amputation[NCT05140499] | Phase 4 | 30 participants (Anticipated) | Interventional | 2022-08-15 | Recruiting | ||
| Evaluation of the Postoperative Analgesic Efficacy of Bilateral Superficial Cervical Block for Thyroidectomy and Mini Incision Under General Balanced Anesthesia: a Randomized, Triple Masked, Placebo Controlled Trial.[NCT01171885] | Phase 4 | 120 participants (Anticipated) | Interventional | 2009-07-31 | Recruiting | ||
| Antagonism Research Between Antiemetics Agents (Droperidol, Dexametasone, Ondansetron) and Acetaminophen in Thyroidectomy's Post-operative Analgesia.[NCT01679093] | Phase 3 | 66 participants (Actual) | Interventional | 2009-06-30 | Completed | ||
| The Effects of Topical Treatment With Clonidine + Pentoxifylline in Patients With Neuropathic Pain[NCT03342950] | Phase 2 | 4 participants (Actual) | Interventional | 2019-02-19 | Terminated (stopped due to Low recruitment due to the COVID-19 pandemic) | ||
| Fascia Iliaca Compartment Block For Analgesia After Total Hip Arthroplasty; A Randomized Double Blind, Placebo-Controlled Trial[NCT01758497] | 32 participants (Actual) | Interventional | 2010-10-31 | Completed | |||
| Prospective Assessment of Intraoperative Intra-articular Morphine and Clonidine Injection in Hip Arthroscopy on Postoperative Pain Management[NCT02530151] | Phase 4 | 70 participants (Actual) | Interventional | 2015-11-30 | Completed | ||
| Use of Intraoperative Clonidine for Prevention of Postoperative Agitation in Pedriatic Anesthesia With Sevoflurane.[NCT02181543] | Phase 3 | 30 participants (Actual) | Interventional | 2013-08-31 | Completed | ||
| Analgesic Effects of Caudal S-ketamine for Supplementation of Ropivacaine Caudal Analgesia in Children With Hypospadias[NCT05922605] | Phase 4 | 44 participants (Anticipated) | Interventional | 2023-06-20 | Recruiting | ||
| Effect of Intravenous Paracetamol in Combination With Caudal Ropivacaine on Quality of Postoperative Recovery in Paediatric Patients Undergoing Hypospadias Repair[NCT03781505] | Phase 4 | 64 participants (Anticipated) | Interventional | 2019-01-31 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
"The Repeated Chair Stand Test is a timed test based on the ability of the participant to perform a series of standing exercises.~This test is germane to subjects with total joint replacement that are easily performed in the clinical settings. The test will capture the domains of muscle strength and activation, and balance." (NCT02891798)
Timeframe: 6 weeks post-operation
| Intervention | seconds (Mean) |
|---|---|
| Bupivacaine + BCD (Buprenorphine, Clonidine, Dexamethasone) | 12.34 |
| Bupivacaine Only (Control Arm) | 11.93 |
"The Self-Selected Gait Speed Test is a timed test based on the ability of the participant to walk a 4 meter distance.~This test is germane to subjects with total joint replacement that are easily performed in the clinical settings. The test captures the ability to walk." (NCT02891798)
Timeframe: 6 weeks post-operation
| Intervention | meters per second (Mean) |
|---|---|
| Bupivacaine + BCD (Buprenorphine, Clonidine, Dexamethasone) | 0.88 |
| Bupivacaine Only (Control Arm) | 0.94 |
"The Standing Balance Test score based on the ability of the participant to perform a series of standing exercises. Scores range from 0 to 4, with 4 indicating a longer time holding the stand (a better outcome).~This test is germane to subjects with total joint replacement that are easily performed in the clinical settings. The test will capture the domains of muscle strength and activation, and balance." (NCT02891798)
Timeframe: 6 weeks post-operation
| Intervention | score on a scale (Mean) |
|---|---|
| Bupivacaine + BCD (Buprenorphine, Clonidine, Dexamethasone) | 3.86 |
| Bupivacaine Only (Control Arm) | 3.94 |
Quality of Recovery 15 Item Scale, total score 0-150, 150 reflecting a perfect score and better recovery. (NCT02891798)
Timeframe: 6 weeks post-operation
| Intervention | score on a scale (Mean) |
|---|---|
| Bupivacaine + BCD (Buprenorphine, Clonidine, Dexamethasone) | 128.89 |
| Bupivacaine Only (Control Arm) | 130.06 |
Quality of Recovery 15 Item Scale, total score 0-150, 150 reflecting a perfect score and better recovery. (NCT02891798)
Timeframe: Day after surgery (7AM-9AM EST)
| Intervention | score on a scale (Mean) |
|---|---|
| Bupivacaine + BCD (Buprenorphine, Clonidine, Dexamethasone) | 106.08 |
| Bupivacaine Only (Control Arm) | 90.13 |
Continuous pain subscore difference of Post-Operative Day 1 value minus the Baseline value. Differences can range from -10 to +10. Negative scores indicate a decrease in pain. (NCT02891798)
Timeframe: Baseline, Post-Operative day after surgery (7AM-9AM EST)
| Intervention | units on a scale (Mean) |
|---|---|
| Bupivacaine + BCD (Buprenorphine, Clonidine, Dexamethasone) | -2.29 |
| Bupivacaine Only (Control Arm) | 0.33 |
Intermittent pain subscore difference of Post-Operative Day 1 value minus the Baseline value. Differences can range from -10 to +10. Negative scores indicate a decrease in pain. (NCT02891798)
Timeframe: Baseline, Post-Operative day after surgery (7AM-9AM EST)
| Intervention | units on a scale (Mean) |
|---|---|
| Bupivacaine + BCD (Buprenorphine, Clonidine, Dexamethasone) | -2.79 |
| Bupivacaine Only (Control Arm) | -1.14 |
SF-MPQ version 2 total score difference of Post-Operative Day 1 value minus the Baseline value. Differences can range from -10 to +10. Negative scores indicate a decrease in pain. (NCT02891798)
Timeframe: Baseline, Post-Operative day after surgery (7AM-9AM EST)
| Intervention | score on a scale (Mean) |
|---|---|
| Bupivacaine + BCD (Buprenorphine, Clonidine, Dexamethasone) | -1.85 |
| Bupivacaine Only (Control Arm) | -0.05 |
Numeric Rating Pain Scores ( 0-10), will be obtained every 2 hours after PACU discharge up to 18 hours or until hospital discharge, whichever occurs first. The pain score of 0, means no pain, is a good outcome , and a pain score of 10 is excruciating pain, a very bad outcome. The average of these scores will be evaluated.The pain scores will not longer be documented after the numbness went away. (NCT02439281)
Timeframe: Logistic regression of the 4 th pain score assessment
| Intervention | units on a scale (Median) |
|---|---|
| Ropivacaine Group | 2 |
| Ropivacaine/ Clonidine Group | 1.5 |
The investigators hypothesize that patient postoperative anxiety scores are lower in the Ropivacaine/Clonidine group and postoperative anxiety scores decrease more in Ropivacaine /Clonidine Group, than in Ropivacaine Group. (NCT02439281)
Timeframe: 6 hours after block placement
| Intervention | units on a scale (Median) |
|---|---|
| Ropivacaine Group | 30 |
| Ropivacaine/ Clonidine Group | 29 |
The investigators expect no difference in incidence of complications (e.g. oversedation, hypotension, bradycardia episodes, etc.). (NCT02439281)
Timeframe: until study completion
| Intervention | Participants (Count of Participants) |
|---|---|
| Ropivacaine/ Clonidine Group | 1 |
| Ropivacaine Group | 1 |
The investigators hypothesize that rectus sheath injections with ropivacaine/ clonidine would result in longer duration of analgesia and decreased pain scores compared to ropivacaine alone. (NCT02439281)
Timeframe: indicated by the first request for pain medication at umbilicus site
| Intervention | minutes (Median) |
|---|---|
| Ropivacaine/ Clonidine Group | 230 |
| Ropivacaine Group | 240 |
The investigators hypothesize that rectus sheath injections with ropivacaine and clonidine result in longer duration of sensory block (paresthesia) compared to ropivacaine alone. (NCT02439281)
Timeframe: Indicated by return of normal sensation (expected average of 12 hours after block placement).
| Intervention | minutes (Median) |
|---|---|
| Ropivacaine/ Clonidine Group | 823.5 |
| Ropivacaine Group | 540 |
Total intravenous morphine equivalents mg/kg (NCT02439281)
Timeframe: 18 hours after surgery
| Intervention | mg/kg (Median) |
|---|---|
| Ropivacaine/ Clonidine Group | 0.20 |
| Ropivacaine Group | 0.22 |
The investigators hypothesize that rectus sheath injections with ropivacaine/ clonidine would result in better satisfaction with pain control. (NCT02439281)
Timeframe: Prior to hospital discharge (up to 24 hours after surgery)
| Intervention | units on a scale (Median) |
|---|---|
| Ropivacaine/ Clonidine Group | 9 |
| Ropivacaine Group | 9 |
morphine equivalents consumed during the entire post-anesthesia care unit (PACU) visit post surgery will be obtained from the All-scripts electronic medical record (EMR) system. (NCT03704376)
Timeframe: Entire post-anesthesia care unit (PACU) visit post surgery, PACU range 1 hr to 12 hrs post surgery
| Intervention | milligrams (mg) (Mean) |
|---|---|
| Femoral Nerve Blockade | 14.8 |
| Adductor Canal Blockade | 16.0 |
The straight leg raise assessment was performed in a standardized long-sitting position with well-knee flexed to 90 degrees. Patients were asked to complete 30 repetitions of straight leg raises with a small bolster supporting the heel using the following criteria; (1) perform with no visible quad lag (2) reach the height of the opposite tibial tubercle and (3) maintain a controlled rate of 30 hertz for the ascending and descending phases. The examination was only performed on the surgical limb and the absolute number of successful repetitions is reported. (NCT03704376)
Timeframe: 4 weeks post operative
| Intervention | number of repetitions (Mean) |
|---|---|
| Femoral Nerve Blockade | 29.7 |
| Adductor Canal Blockade | 30 |
The straight leg raise assessment was performed in a standardized long-sitting position with well-knee flexed to 90 degrees. Patients were asked to complete 30 repetitions of straight leg raises with a small bolster supporting the heel using the following criteria; (1) perform with no visible quad lag (2) reach the height of the opposite tibial tubercle and (3) maintain a controlled rate of 30 hertz for the ascending and descending phases. The examination was only performed on the surgical limb and the absolute number of successful repetitions is reported. (NCT03704376)
Timeframe: Post-operative day 1
| Intervention | number of repetitions (Mean) |
|---|---|
| Femoral Nerve Blockade | 3.2 |
| Adductor Canal Blockade | 6.2 |
The straight leg raise assessment was performed in a standardized long-sitting position with well-knee flexed to 90 degrees. Patients were asked to complete 30 repetitions of straight leg raises with a small bolster supporting the heel using the following criteria; (1) perform with no visible quad lag (2) reach the height of the opposite tibial tubercle and (3) maintain a controlled rate of 30 hertz for the ascending and descending phases. The examination was only performed on the surgical limb and the absolute number of successful repetitions is reported. (NCT03704376)
Timeframe: Post-operative day 14
| Intervention | number of repetitions (Mean) |
|---|---|
| Femoral Nerve Blockade | 23.3 |
| Adductor Canal Blockade | 24.2 |
The items are scored on a visual analogical scale from 0-10, 0 being the better outcome. (NCT03704376)
Timeframe: 1 hr post surgery
| Intervention | units on a scale (Mean) |
|---|---|
| Femoral Nerve Blockade | 0.81 |
| Adductor Canal Blockade | 0.8 |
The items are scored on a visual analogical scale from 0-10, with 0 being the better (NCT03704376)
Timeframe: 3 hr post surgery
| Intervention | units on a scale (Mean) |
|---|---|
| Femoral Nerve Blockade | 2.65 |
| Adductor Canal Blockade | 3.23 |
The items are scored on a visual analogical scale from 0-10, with 0 being the better outcome. (NCT03704376)
Timeframe: 10 hr post surgery
| Intervention | units on a scale (Mean) |
|---|---|
| Femoral Nerve Blockade | 2 |
| Adductor Canal Blockade | 2.53 |
The items are scored on a visual analogical scale from 0-10, with 0 being the better outcome. (NCT03704376)
Timeframe: 2 hr post surgery
| Intervention | units on a scale (Mean) |
|---|---|
| Femoral Nerve Blockade | 1.78 |
| Adductor Canal Blockade | 2.13 |
The items are scored on a visual analogical scale from 0-10, with 0 being the better outcome. (NCT03704376)
Timeframe: 4 hr post surgery
| Intervention | units on a scale (Mean) |
|---|---|
| Femoral Nerve Blockade | 2.83 |
| Adductor Canal Blockade | 2.87 |
The items are scored on a visual analogical scale from 0-10, with 0 being the better outcome. (NCT03704376)
Timeframe: 5 hr post surgery
| Intervention | units on a scale (Mean) |
|---|---|
| Femoral Nerve Blockade | 2.97 |
| Adductor Canal Blockade | 3.06 |
The items are scored on a visual analogical scale from 0-10, with 0 being the better outcome. (NCT03704376)
Timeframe: 6 hr post surgery
| Intervention | units on a scale (Mean) |
|---|---|
| Femoral Nerve Blockade | 2.63 |
| Adductor Canal Blockade | 3.03 |
The items are scored on a visual analogical scale from 0-10, with 0 being the better outcome. (NCT03704376)
Timeframe: 7 hr post surgery
| Intervention | units on a scale (Mean) |
|---|---|
| Femoral Nerve Blockade | 2.83 |
| Adductor Canal Blockade | 2.81 |
The items are scored on a visual analogical scale from 0-10, with 0 being the better outcome. (NCT03704376)
Timeframe: 8 hr post surgery
| Intervention | units on a scale (Mean) |
|---|---|
| Femoral Nerve Blockade | 2.84 |
| Adductor Canal Blockade | 2.57 |
The items are scored on a visual analogical scale from 0-10, with 0 being the better outcome. (NCT03704376)
Timeframe: 9 hr post surgery
| Intervention | units on a scale (Mean) |
|---|---|
| Femoral Nerve Blockade | 2.91 |
| Adductor Canal Blockade | 2.41 |
Quadriceps muscle activation was examined using surface electromyography (sEMG) of the vastus medialis oblique muscle. Peak sEMG activity was recorded in microvolts (uV) on the surgical and contralateral limbs while performing five maximal effort isometric contractions in full knee extension--the reported values are equal to the quadriceps sEMG in uV of the contralateral limb minus the quadriceps sEMG in uV of the surgical limb. (NCT03704376)
Timeframe: 4 weeks post operative
| Intervention | microvolts (uV) (Mean) |
|---|---|
| Femoral Nerve Blockade | 109.1 |
| Adductor Canal Blockade | 94.1 |
Quadriceps muscle activation was examined using surface electromyography (sEMG) of the vastus medialis oblique muscle. Peak sEMG activity was recorded in microvolts (uV) on the surgical and contralateral limbs while performing five maximal effort isometric contractions in full knee extension--the reported values are equal to the quadriceps sEMG in uV of the contralateral limb minus the quadriceps sEMG in uV of the surgical limb. (NCT03704376)
Timeframe: Post-operative day 14
| Intervention | microvolts (uV) (Mean) |
|---|---|
| Femoral Nerve Blockade | 183.2 |
| Adductor Canal Blockade | 126.5 |
Quadriceps muscle activation was examined using surface electromyography (sEMG) of the vastus medialis oblique muscle. Peak sEMG activity was recorded in microvolts (uV) on the surgical and contralateral limbs while performing five maximal effort isometric contractions in full knee extension--the reported values are equal to the quadriceps sEMG in uV of the contralateral limb minus the quadriceps sEMG in uV of the surgical limb. (NCT03704376)
Timeframe: Post-operative day 1
| Intervention | microvolts (uV) (Mean) |
|---|---|
| Femoral Nerve Blockade | 266.5 |
| Adductor Canal Blockade | 212.5 |
From day of surgery (Day 0) until discharge after surgery (NCT02026687)
Timeframe: Participants will be followed for the duration of hospital stay, an expected average of 4 days
| Intervention | days (Median) |
|---|---|
| Epidural | 4.3 |
| Spinal | 3.3 |
"Pain at rest will be assessed using a numeric rating scale from 0 (no pain) to 10 (worst imaginable pain). Pain is documented on the day of surgery (day 0), 3 times daily postoperative day 1, 2, 3, 4, 5, 6, 7, 14, 21, 28, 35 and 42.~Scale: NRS Minimum value:0 Maximum value: 10. Higher scores indicate worse outcome." (NCT02026687)
Timeframe: Day of surgery (day 0) until 6 weeks after surgery
| Intervention | units on a scale (Mean) | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Pain at rest Day 0 | Pain at rest Day 1 | Pain at rest Day 2 | Pain at rest Day 3 | Pain at rest Day 4 | Pain at rest Day 5 | Pain at rest Day 6 | Pain at rest Day 7 | Pain at rest Day 14 | Pain at rest Day 21 | Pain at rest Day 28 | Pain at rest Day 35 | Pain at rest Day 42 | |
| Epidural | 1.5 | 1.6 | 1.5 | 2.9 | 1.4 | 1.1 | 1.0 | 1.1 | 0.8 | 0.5 | 0.2 | 0.3 | 0.5 |
| Spinal | 2.7 | 3.2 | 2.1 | 1.4 | 1.6 | 1.2 | 1.1 | 1.0 | 0.7 | 0.3 | 0.2 | 0.3 | 0.1 |
"The questionnaire Short Form with 36 questions SF-36 will be used preoperatively and at 6 weeks after surgery. The SF-36 consists of eight scaled subscores (vitality, physical functioning, bodily pain, general health perceptions, physical role functioning, emotional role functioning, social role functioning, mental Health) and two Component summary scores (physical Component summary scoer, mental component summary score). A score of zero is equivalent to maximum disability and a score of 100 is equivalent to no disability." (NCT02026687)
Timeframe: Preoperatively and until 6 weeks after surgery
| Intervention | units on a scale (Median) | |||
|---|---|---|---|---|
| SF-36 Physical component summary score baseline | SF-36 Physical component summary score day 42 | SF-36 mental component summary score baseline | SF-36 mental component summary score day 42 | |
| Epidural | 44 | 39 | 46 | 49 |
| Spinal | 45 | 38 | 46 | 51 |
The Montgomery-Asberg Depression Rating Scale (MADRS) is a 10-item scale that measures the severity of depression, with a higher score indicating a higher level of depression. The range of scores is 0 to 60. (NCT01179009)
Timeframe: 8 weeks
| Intervention | Scores on a scale (Mean) |
|---|---|
| Ketamine 100-hour Infusion | -9.0 |
| Ketamine 40-minute Infusion | -6.4 |
First mobilization time after surgery (NCT03479216)
Timeframe: 24 hours
| Intervention | minutes (Mean) |
|---|---|
| Precedex | 143.27 |
| Magnesium Sulfate | 139.42 |
post-injection complications due to intraarticular injection will be noted. (NCT03479216)
Timeframe: 24 hours
| Intervention | Participants (Count of Participants) |
|---|---|
| Precedex | 0 |
| Magnesium Sulfate | 0 |
Time to first analgesic demand at the orthopedics ward (from intraarticular injection to first analgesic requirement) (NCT03479216)
Timeframe: 24 hours
| Intervention | minutes (Mean) |
|---|---|
| Precedex | 477.33 |
| Magnesium Sulfate | 498.46 |
time from skin incision to closure (NCT03479216)
Timeframe: 24 hours
| Intervention | minutes (Mean) |
|---|---|
| Precedex | 24.23 |
| Magnesium Sulfate | 25.58 |
time from the start of spinal anesthesia (total block = Bromage 3) to the end of spinal anesthesia (Bromage 0) (NCT03479216)
Timeframe: 24 hours
| Intervention | minutes (Mean) |
|---|---|
| Precedex | 148.1 |
| Magnesium Sulfate | 147.5 |
nonsteroid antiinflammatory drugs (NSAID) or opioid drugs that are applied to patients will be noted. (NCT03479216)
Timeframe: 24 hours
| Intervention | vials (Number) | |
|---|---|---|
| NSAID | opioid | |
| Magnesium Sulfate | 14 | 1 |
| Precedex | 17 | 0 |
postoperative pain scores (rest and movement) (ward) Pain scores were assessed with a 10-cm Visual Analogue Scale (VAS) (with 0 = no pain and 10 = the worst imaginable pain) (NCT03479216)
Timeframe: 24 hours
| Intervention | score on a scale (Mean) | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| VAS 2 R | VAS2 M | VAS4 R | VAS4 M | VAS6 R | VAS6 M | VAS8 R | VAS8 M | VAS12 R | VAS12 M | VAS18 R | VAS18 M | |
| Magnesium Sulfate | 0.04 | 0.23 | 0.12 | 1.19 | 1.31 | 3.31 | 1.77 | 4.08 | 1.15 | 3.19 | 0.27 | 1.69 |
| Precedex | 0 | 0.19 | 0.81 | 2.04 | 1.50 | 3.46 | 1.23 | 3.08 | 0.73 | 2.62 | 0.23 | 1.62 |
The Opioid-Related Symptom Distress Scale (ORSDS) is a Likert scale that evaluates 3 symptom distress dimensions (frequency, severity, bothersomeness) for 12 symptoms. Frequency is rated on a 4-point scale (1= 'Rarely', 4= 'Almost constantly'). Severity is rated on a 4-point scale (1= 'Slightly', 4= 'Very'). Bothersomeness is rated on a 5-point scale (0.8= 'Not at all', 4.0= 'Very much'). The symptom-specific ORSDS is the average of the 3 symptom distress dimensions. The composite ORSDS score is the average of 12 symptom-specific scores. (NCT03020966)
Timeframe: 24 hours after surgery (Post-operative day 1)
| Intervention | score on a scale (Mean) |
|---|---|
| Oral Tylenol | 0.4 |
| Intravenous Tylenol | 0.3 |
Oral morphine equivalents, cumulative, POD 0-3. Recorded in Medication Usage Database. (NCT03020966)
Timeframe: Day of surgery to post-operative day 3
| Intervention | Oral Morphine Equivalent (mg) (Mean) |
|---|---|
| Oral Tylenol | 108 |
| Intravenous Tylenol | 121 |
Numerical rating scale of pain on a scale of 0-10, with 0 representing the minimum value of no pain and 10, representing the maximum, defined as being pain as bad as imaginable. (NCT03020966)
Timeframe: 24 hours after the operation (post-operative day 1)
| Intervention | score on a scale (Mean) |
|---|---|
| Oral Tylenol | 3.6 |
| Intravenous Tylenol | 3.9 |
American Shoulder and Elbow Surgeons (ASES) Shoulder Score for pain and function. Range 0-100. Low score = worse shoulder condition. Function, disability, and pain subscores (all ranges 0-50), and are summed for total ASES score. (NCT03540030)
Timeframe: 2 Weeks
| Intervention | units on a scale (Median) |
|---|---|
| Observational | 54.3 |
| Non-Opioid Intervention | 54.2 |
Morphine milli-equivalents In-hospital post-operative. Continuous scale of MME, no defined better/worse. Measured as number and dose of medications taken. For example, if the patient received an opioid, the drug and dose was recorded and converted to MME. A time frame of when to assess opioid use in-hospital post-operative was not used but was a continuous monitor for rescue opioid from in-hospital post-operative through discharge. (NCT03540030)
Timeframe: In-hospital Stay
| Intervention | Morphine milli-equivalents (Median) |
|---|---|
| Observational | 45.0 |
| Non-Opioid Intervention | 19.0 |
Pain at patient discharge or 24-hours, whichever comes first - measured on a 0 (no pain) -10 (worst possible pain) numeric rating scale (NRS). A score of 0(no pain) is preferable to 10(worst possible pain) (NCT03540030)
Timeframe: 24 hours
| Intervention | score on a scale (Median) |
|---|---|
| Observational | 3.0 |
| Non-Opioid Intervention | 2.0 |
Simple Shoulder Test (SST) activity score. Range 0-12. 0 = worse activity score. (NCT03540030)
Timeframe: 2 Months
| Intervention | score on a scale (Median) |
|---|---|
| Observational | 6 |
| Non-Opioid Intervention | 6 |
Simple Shoulder Test (SST) activity score. Range 0-12. 0 = worse activity score. (NCT03540030)
Timeframe: 2 Weeks
| Intervention | score on a scale (Median) |
|---|---|
| Observational | 2.0 |
| Non-Opioid Intervention | 2.0 |
post-operative pain: measured on a 0 (no pain) -10 (worst) numeric rating scale (NRS) at 6hrs, 12hrs, 2 weeks, and 2 months. A score of 0(no pain) is preferable to 10(worst possible pain) (NCT03540030)
Timeframe: 6hrs, 12hrs, 2weeks, 2 months
| Intervention | score on a scale (Median) | |||
|---|---|---|---|---|
| 6 Hrs | 12 hrs | 2 weeks | 2 months | |
| Non-Opioid Intervention | 0.0 | 0 | 0.82 | 0 |
| Observational | 2 | 4 | 1.3 | 0.7 |
rate of constipation (NCT03540030)
Timeframe: 2 Months
| Intervention | Participants (Count of Participants) | ||
|---|---|---|---|
| Yes | No | Unknown | |
| Non-Opioid Intervention | 4 | 27 | 4 |
| Observational | 7 | 21 | 2 |
rate of constipation (NCT03540030)
Timeframe: 2 Weeks
| Intervention | Participants (Count of Participants) | ||
|---|---|---|---|
| Yes | No | Unknown | |
| Non-Opioid Intervention | 13 | 22 | 0 |
| Observational | 19 | 9 | 2 |
rate of falls (NCT03540030)
Timeframe: 2 Months
| Intervention | Participants (Count of Participants) | ||
|---|---|---|---|
| Yes | No | Unknown | |
| Non-Opioid Intervention | 4 | 27 | 4 |
| Observational | 4 | 24 | 2 |
rate of falls (NCT03540030)
Timeframe: 2 Weeks
| Intervention | Participants (Count of Participants) | ||
|---|---|---|---|
| Yes | No | Unknown | |
| Non-Opioid Intervention | 5 | 30 | 0 |
| Observational | 1 | 27 | 2 |
rate of nausea (NCT03540030)
Timeframe: 2 Months
| Intervention | Participants (Count of Participants) | ||
|---|---|---|---|
| Yes | No | Unknown | |
| Non-Opioid Intervention | 1 | 30 | 0 |
| Observational | 0 | 28 | 2 |
rate of nausea (NCT03540030)
Timeframe: 2 Weeks
| Intervention | Participants (Count of Participants) | ||
|---|---|---|---|
| Yes | No | Unknown | |
| Non-Opioid Intervention | 1 | 34 | 0 |
| Observational | 5 | 23 | 2 |
Satisfaction with overall pain using Numeric Pain Rating (NRS) scale. yes, no. No being better than yes. (NCT03540030)
Timeframe: 2 Months
| Intervention | Participants (Count of Participants) | ||
|---|---|---|---|
| Yes | No | Unknown | |
| Non-Opioid Intervention | 29 | 2 | 4 |
| Observational | 23 | 5 | 2 |
Satisfaction with overall pain using Numeric Pain Rating (NRS) scale. yes, no. No being better than yes. (NCT03540030)
Timeframe: 2 Weeks
| Intervention | Participants (Count of Participants) | ||
|---|---|---|---|
| Yes | No | Unknown | |
| Non-Opioid Intervention | 34 | 1 | 0 |
| Observational | 27 | 1 | 2 |
quality of life using VR-12 subscores. Physical Health (PCS) subscore and Mental Health (MCS) subscore, not summed. Range reported in weighted units. Physical Health subscore: 1 point increase in PCS is associated with 6% lower total health care expenditures, 5% lower pharmacy expenditures, 9% lower rate of hospital inpatient visits, 4% lower rate of medical provider visits, 5% lower rate of hospital outpatient visits. Mental Health sub score a 1 point increase in MCS is associated with 7% lower total health care expenditures, 4% lower pharmacy expenditures, 15% lower rate of hospital inpatient visits, and 4% lower rate of medical provider visits. Both PCS/MCS are score 0-100 with 100 indicating the highest level of health. (NCT03540030)
Timeframe: 2 Months
| Intervention | score on a scale (Median) | |
|---|---|---|
| PCS | MCS | |
| Non-Opioid Intervention | 40.3 | 60.8 |
| Observational | 38.4 | 58.7 |
quality of life using VR-12 subscores. Physical Health (PCS) subscore and Mental Health (MCS) subscore, not summed. Range reported in weighted units. Physical Health subscore: 1 point increase in PCS is associated with 6% lower total health care expenditures, 5% lower pharmacy expenditures, 9% lower rate of hospital inpatient visits, 4% lower rate of medical provider visits, 5% lower rate of hospital outpatient visits. Mental Health sub score a 1 point increase in MCS is associated with 7% lower total health care expenditures, 4% lower pharmacy expenditures, 15% lower rate of hospital inpatient visits, and 4% lower rate of medical provider visits. Both PCS/MCS are score 0-100 with 100 indicating the highest level of health. (NCT03540030)
Timeframe: 2 Weeks
| Intervention | score on a scale (Median) | |
|---|---|---|
| PCS | MCS | |
| Non-Opioid Intervention | 35.0 | 59.1 |
| Observational | 36.7 | 56.3 |
Determine which of three different TAP formulations (Placebo, TAP, Clo-TAP) has the most beneficial effect on the postoperative area of hyperalgesia 48hrs after the start of the cesarean section. The smaller the area of WHA, assessed in cm2, the better the outcome. Area sizes may range from 0 to any size. (NCT01015807)
Timeframe: 48hrs after CS
| Intervention | cm^2 (Mean) |
|---|---|
| Placebo | 1.07 |
| TAP (Bupi) | 1.27 |
| Clo-TAP (Bupi + Clon) | 0.74 |
Sleep time change from 96 hours before surgery to 72 hours after surgery (NCT01505465)
Timeframe: 96 hours before surgery to 72 hours after surgery
| Intervention | minutes (Mean) |
|---|---|
| Study: Melatonin | 20 |
| Control: Placebo | -55 |
The median number of intravenous fentanyl doses administered in the PACU due to pain (NCT00678379)
Timeframe: in recovery room
| Intervention | number of doses (Median) |
|---|---|
| Normal Saline | 3.0 |
| Lidocaine (1%) + Bupivacaine 0.5% | 3 |
| Lidocaine 1% + Bupivacaine o.5% + Clondine 25mcg | 3 |
The total number of intravenous fentanyl doses given PACU which will be compared between the three randomized groups (arms) (NCT00678379)
Timeframe: Post-operative thru day 7
| Intervention | number of doses (Median) |
|---|---|
| Normal Saline | 12 |
| Lidocaine (1%) + Bupivacaine 0.5% | 12 |
| Lidocaine 1% + Bupivacaine o.5% + Clondine 25mcg | 14 |
(NCT00678379)
Timeframe: Day of Surgery
| Intervention | minutes (Median) |
|---|---|
| Normal Saline | 122 |
| Lidocaine (1%) + Bupivacaine 0.5% | 111 |
| Lidocaine 1% + Bupivacaine o.5% + Clondine 25mcg | 120 |
Visual analog pain scale range is 0-10 with 0=no pain and 10 = worst pain ever (NCT00678379)
Timeframe: in recovery room; post-operative days 1,3,5 & 7
| Intervention | pain score (Mean) | ||||
|---|---|---|---|---|---|
| In recovery room | day 1 | day 3 | day 5 | day 7 | |
| Lidocaine (1%) + Bupivacaine 0.5% | 3 | 4 | 2.5 | 2 | 2 |
| Lidocaine 1% + Bupivacaine o.5% + Clondine 25mcg | 3 | 5 | 3 | 3 | 2 |
| Normal Saline | 3 | 3 | 3 | 3 | 2.5 |
The number and percent of patients whose post-operative diet has to a regular diet on post-operative days 1, 3, 5 & 7 (NCT00678379)
Timeframe: post-operative days 1,3,5 & 7.
| Intervention | Participants (Count of Participants) | |||
|---|---|---|---|---|
| post-op day 1 | post-op day 3 | post op day 5 | post op day 7 | |
| Lidocaine (1%) + Bupivacaine 0.5% | 4 | 8 | 18 | 26 |
| Lidocaine 1% + Bupivacaine o.5% + Clondine 25mcg | 1 | 12 | 14 | 22 |
| Normal Saline | 7 | 18 | 21 | 24 |
The number and percent of patients whose post-operative diet has only advanced to a soft diet on post-operative days 1, 3, 5 & 7 (NCT00678379)
Timeframe: post-operative days 1,3,5 & 7.
| Intervention | Participants (Count of Participants) | |||
|---|---|---|---|---|
| post-op day 1 | post-op day 3 | post op day 5 | post op day 7 | |
| Lidocaine (1%) + Bupivacaine 0.5% | 22 | 26 | 17 | 10 |
| Lidocaine 1% + Bupivacaine o.5% + Clondine 25mcg | 26 | 18 | 18 | 14 |
| Normal Saline | 26 | 18 | 13 | 13 |
The number and percent of patients whose post-operative diet has advanced to liquids only on post-op days 1, 3, 5 & 7 (NCT00678379)
Timeframe: post-operative days 1,3,5 & 7.
| Intervention | Participants (Count of Participants) | |||
|---|---|---|---|---|
| post-op day 1 | post-op day 3 | post op day 5 | post op day 7 | |
| Lidocaine (1%) + Bupivacaine 0.5% | 33 | 13 | 10 | 11 |
| Lidocaine 1% + Bupivacaine o.5% + Clondine 25mcg | 30 | 23 | 19 | 10 |
| Normal Saline | 16 | 8 | 13 | 6 |
(NCT02882854)
Timeframe: Time frame between arrival and discharge in PACU, approximately 90 minutes
| Intervention | minutes (Median) |
|---|---|
| Guanfacine | 128 |
| Placebo | 110 |
PONV assessed using nVRS at 24 hours postop when 0 is no nausea and 10 is worst nausea. (NCT02882854)
Timeframe: 24 hours post op
| Intervention | score on a scale (Median) |
|---|---|
| Guanfacine | 0.00 |
| Placebo | 0.00 |
Postoperative pain assessment using VAS at 24 hours postop when 0 is no pain and 10 is worst pain (NCT02882854)
Timeframe: 24 hours postop
| Intervention | score on a scale (Median) |
|---|---|
| Guanfacine | 3 |
| Placebo | 2 |
Total narcotic requirement in PACU tallied in morphine equivalents during PACU stay (NCT02882854)
Timeframe: Time frame between arrival and discharge in PACU, approximately 90 minutes
| Intervention | morphine equivalents (Median) |
|---|---|
| Guanfacine | 8.75 |
| Placebo | 7.50 |
Maximum postoperative pain assessment assessed in PACU at 15, 30 and 60 minutes after PACU arrival using VAS when 0 is no pain and 10 is worst pain (NCT02882854)
Timeframe: 15, 30, 60 minutes after arriving in PACU
| Intervention | Participants (Count of Participants) | |||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 15 minutes after PACU admission72482977 | 15 minutes after PACU admission72482978 | 30 minutes after PACU admission72482977 | 30 minutes after PACU admission72482978 | 60 minutes after PACU admission72482977 | 60 minutes after PACU admission72482978 | |||||||||||||
| Mild (Pain nVRS 1-5) | Moderate/Severe (Pain nVRS 6-10) | None (Pain nVRS 0) | ||||||||||||||||
| Guanfacine | 31 | |||||||||||||||||
| Placebo | 24 | |||||||||||||||||
| Guanfacine | 0 | |||||||||||||||||
| Placebo | 5 | |||||||||||||||||
| Guanfacine | 8 | |||||||||||||||||
| Placebo | 10 | |||||||||||||||||
| Guanfacine | 18 | |||||||||||||||||
| Placebo | 20 | |||||||||||||||||
| Guanfacine | 7 | |||||||||||||||||
| Placebo | 6 | |||||||||||||||||
| Guanfacine | 14 | |||||||||||||||||
| Placebo | 14 | |||||||||||||||||
| Guanfacine | 12 | |||||||||||||||||
| Placebo | 16 | |||||||||||||||||
| Guanfacine | 6 | |||||||||||||||||
| Placebo | 13 | |||||||||||||||||
| Guanfacine | 21 | |||||||||||||||||
| Placebo | 12 | |||||||||||||||||
Patients are assessed from needle removal to when they are no longer able to feel cold on the blocked extremity (NCT03117140)
Timeframe: Day one
| Intervention | minutes (Median) |
|---|---|
| Plain Ropivacaine | 6 |
| Ropivacaine + Buprenorphine | 3 |
| Ropivacaine + Clonidine | 6 |
| Ropivacaine + Dexamethasone | 4.5 |
Patients are called 1-3 days post-operatively to assess when the analgesia of their nerve block wore off (NCT03117140)
Timeframe: 1-3 days post-operative
| Intervention | minutes (Median) |
|---|---|
| Plain Ropivacaine | 911 |
| Ropivacaine + Buprenorphine | 1026.5 |
| Ropivacaine + Clonidine | 1181 |
| Ropivacaine + Dexamethasone | 982 |
Patients are called 1-3 days post-operatively to assess when motor component of their nerve block wore off (NCT03117140)
Timeframe: Day 1-3
| Intervention | minutes (Median) |
|---|---|
| Plain Ropivacaine | 1120 |
| Ropivacaine + Buprenorphine | 1198 |
| Ropivacaine + Clonidine | 1090 |
| Ropivacaine + Dexamethasone | 1143.5 |
Blood pressure changes in Second Stage Recovery Area for patients was looked at (NCT03117140)
Timeframe: Post-op Day 0 (baseline)
| Intervention | Participants (Count of Participants) |
|---|---|
| Plain Ropivacaine | 5 |
| Ropivacaine + Buprenorphine | 1 |
| Ropivacaine + Clonidine | 5 |
| Ropivacaine + Dexamethasone | 0 |
Patients are called 1-3 days post-operatively to assess if they had any side effects of the adjuvants such as nausea, vomiting or itching. There blood pressure is looked at pre-op and compared to post-op. Any prolonged PACU (Post Anesthesia Care Unit) stay for sedation is recorded. (NCT03117140)
Timeframe: 1-3 days
| Intervention | Participants (Count of Participants) |
|---|---|
| Plain Ropivacaine | 1 |
| Ropivacaine + Buprenorphine | 2 |
| Ropivacaine + Clonidine | 2 |
| Ropivacaine + Dexamethasone | 0 |
Patients itching was assessed post-op in the PACU. (NCT03117140)
Timeframe: Post-op day 0 (baseline)
| Intervention | Participants (Count of Participants) |
|---|---|
| Plain Ropivacaine | 5 |
| Ropivacaine + Buprenorphine | 2 |
| Ropivacaine + Clonidine | 6 |
| Ropivacaine + Dexamethasone | 3 |
Patients are called 1-3 days post-operatively to assess if they had any side effects of the adjuvants such as nausea, vomiting or itching. There blood pressure is looked at pre-op and compared to post-op. Any prolonged PACU (Post Anesthesia Care Unit) stay for sedation is recorded. (NCT03117140)
Timeframe: 1-3 days
| Intervention | Participants (Count of Participants) |
|---|---|
| Plain Ropivacaine | 4 |
| Ropivacaine + Buprenorphine | 9 |
| Ropivacaine + Clonidine | 2 |
| Ropivacaine + Dexamethasone | 3 |
PACU (Post-Anesthesia Care Unit) assessment of nausea (NCT03117140)
Timeframe: Post-op day 0 (Baseline)
| Intervention | Participants (Count of Participants) |
|---|---|
| Plain Ropivacaine | 4 |
| Ropivacaine + Buprenorphine | 9 |
| Ropivacaine + Clonidine | 2 |
| Ropivacaine + Dexamethasone | 9 |
Vomiting in PACU (Post-Anesthesia Care Unit) for patients was looked at (NCT03117140)
Timeframe: Post-op Day 0 (Baseline)
| Intervention | Participants (Count of Participants) |
|---|---|
| Plain Ropivacaine | 0 |
| Ropivacaine + Buprenorphine | 1 |
| Ropivacaine + Clonidine | 0 |
| Ropivacaine + Dexamethasone | 0 |
Blood pressure changes in PACU (Post-Anesthesia Care Unit) for patients was looked at (NCT03117140)
Timeframe: Post-op Day 0 (baseline)
| Intervention | Participants (Count of Participants) |
|---|---|
| Plain Ropivacaine | 8 |
| Ropivacaine + Buprenorphine | 3 |
| Ropivacaine + Clonidine | 7 |
| Ropivacaine + Dexamethasone | 2 |
Patients are called 1-3 days post-operatively to assess pain. Pain score is 0-10 scale with 0 is no pain and 10 is most severe pain. (NCT03117140)
Timeframe: Day 1-3
| Intervention | units on a scale (Median) |
|---|---|
| Plain Ropivacaine | 4 |
| Ropivacaine + Buprenorphine | 3 |
| Ropivacaine + Clonidine | 4 |
| Ropivacaine + Dexamethasone | 3 |
Patients are called 1-3 days post-operatively to assess if they had any side effects of the adjuvants such as nausea, vomiting or itching. There blood pressure is looked at pre-op and compared to post-op. Any prolonged PACU (Post Anesthesia Care Unit) stay for sedation is recorded. (NCT03117140)
Timeframe: 1-3 days
| Intervention | Participants (Count of Participants) |
|---|---|
| Plain Ropivacaine | 0 |
| Ropivacaine + Buprenorphine | 3 |
| Ropivacaine + Clonidine | 2 |
| Ropivacaine + Dexamethasone | 1 |
Patients are called 1-3 days post-operatively to assess when the sensory component of their nerve block wore off (NCT03117140)
Timeframe: Day 1-3
| Intervention | minutes (Median) |
|---|---|
| Plain Ropivacaine | 923.5 |
| Ropivacaine + Buprenorphine | 982 |
| Ropivacaine + Clonidine | 940.5 |
| Ropivacaine + Dexamethasone | 1066 |
Surgical length was recorded (NCT03117140)
Timeframe: Post op Day 0 (Baseline)
| Intervention | minutes (Median) |
|---|---|
| Plain Ropivacaine | 68.5 |
| Ropivacaine + Buprenorphine | 65 |
| Ropivacaine + Clonidine | 73.5 |
| Ropivacaine + Dexamethasone | 71 |
Surgical position was recorded (NCT03117140)
Timeframe: Post-op Day 0 (Baseline)
| Intervention | Participants (Count of Participants) | ||
|---|---|---|---|
| Beach Chair | Lateral | Supine | |
| Plain Ropivacaine | 38 | 2 | 0 |
| Ropivacaine + Buprenorphine | 31 | 6 | 3 |
| Ropivacaine + Clonidine | 31 | 7 | 2 |
| Ropivacaine + Dexamethasone | 32 | 6 | 2 |
"Subjects baseline blood pressure (systolic blood pressure (SBP), and diastolic blood pressure (DBP)), and blood pressures after clonidine injection was compared against baseline to assess efficacy of clonidine in refractory hypertensive subjects. Subject's blood pressure was monitored continuously after intrathecal injection of clonidine until subjects blood pressure nadir and return to pre clonidine injection level. The mean value reported below are the average changes in blood pressure from baseline (pre clonidine injection) in both SBP and DBP during post clonidine injection blood pressure monitoring for 4 hours.~Blood pressure measurements were collected every 10 minutes for first hour after injection, and every 15 minutes after the first hour, up to 4 hours were averaged to report the change from baseline." (NCT01297335)
Timeframe: Baseline, Every 10 Minutes for first hour after clonidine injection, and every 15 minutes after first hour, until 4 hours after clonidine injection
| Intervention | mm Hg (Mean) | |
|---|---|---|
| Change in mean SBP after clonidine injection | Change in DBP after clonidine injection | |
| Intrathecal Clonidine | 79 | 37 |
Subjects were asked to rate severity of two of the most common side effects of clonidine, sedation and sensation of dry mouth, at pre and post (1 hour after) intrathecal administration of clonidine. The mean changes between pre and post injection VAS ratings of sedation and sensation of dry mouth are reported below. The VAS scale ranges from 1 to 10 cm, with higher values indicating higher level of sedation and higher level of dry mouth. (NCT01297335)
Timeframe: Before clonidine injection (Baseline), and at 1 hour after clonidine injection.
| Intervention | cm (Mean) | |
|---|---|---|
| Change in level of sedation | Change in sensation of dry mouth | |
| Intrathecal Clonidine | 3.36 | 3.47 |
Likert scale is 11 point digital pain rating system that asks subjects to rate their pain from 0 to 10. Rating of 0 means no pain at all, and in increasing order, 10 would mean worst pain imaginable/ unbearable pain. (NCT01297335)
Timeframe: Pre-dose and 1 hour post injection.
| Intervention | units on a scale (Mean) | |
|---|---|---|
| Pre-injection average Likert score | Post-injection average Likert score | |
| Intrathecal Clonidine | 6.5 | 3.6 |
Patients will be observed with behaviors rated at regular time intervals using the CHIPPS (Children and Infants Postoperative Pain Scale) pain survey. The CHIPPS scale values range from a minimum of 0 (no pain, better outcome) to a maximum of 10 (worst pain, worse outcome). (NCT01638052)
Timeframe: 60 minutes
| Intervention | units on a scale (Mean) |
|---|---|
| 0.25% Bupivacaine | 2 |
| 0.25% Bupivacaine + Clonidine | 1.9 |
Count of participants who will require use of rescue analgesic medication in the initial 24 hours postoperatively as recorded in the hospital or by parents at home following discharge. (NCT01638052)
Timeframe: 24 hours
| Intervention | Participants (Count of Participants) |
|---|---|
| 0.25% Bupivacaine | 18 |
| 0.25% Bupivacaine + Clonidine | 22 |
Incidence of nausea/vomiting during 24 hour observation (NCT01638052)
Timeframe: 24 hours
| Intervention | Participants (Count of Participants) |
|---|---|
| 0.25% Bupivacaine | 14 |
| 0.25% Bupivacaine + Clonidine | 10 |
The total usage of opioid medication (mEq) for pain relief in the intraoperative period and again through the postoperative recovery period from arrival in the PACU through 7 days post op (NCT02530151)
Timeframe: Recorded intraoperatively, during PACU stay, 6 hours post discharge, 18 hours post discharge, 24 hours post discharge, 48 hours post discharge, and at 7 days post discharge
| Intervention | milligram morphine equivalents (mEq) (Mean) | ||||||
|---|---|---|---|---|---|---|---|
| Intraoperative | PACU | 6 hours Post Discharge | 18 hours Post Discharge | 24 hours Post Discharge | 48 hours Post Discharge | 7 days Post Discharge | |
| Morphine With Clonidine | 57.3 | 37.0 | 5.5 | 14.5 | 19.5 | 27.7 | 50.7 |
| Normal Saline | 56.0 | 40.1 | 5.3 | 13.8 | 20.0 | 35.6 | 73.8 |
The Quality of Recovery questionnaire (QoR-15) is a 15 question patient reported outcome measure used to evaluate the quality of recovery following surgical anesthesia concerning pain, physical function, and psychological factors; reported as a summative score with each question graded between 0-10 (Range:0-150) with higher scores indicating improved physical/psychological recovery or infrequent symptoms (NCT02530151)
Timeframe: Preoperative to 24 hrs. post operatively
| Intervention | score on a scale (Mean) | |
|---|---|---|
| Preoperative QoR-15 Score | Change in QoR-15 Score at 24 hrs. Post Op | |
| Morphine With Clonidine | 123 | -22 |
| Normal Saline | 131 | -20 |
Patients will rate their pain (0-10) on the Visual Analog Scale with higher scores for the VAS indicated elevated pain intensity reported by the patient for the indicated time point (NCT02530151)
Timeframe: Immediately preoperative (5-10 minutes before surgery), immediately postoperative (5-10 minutes after surgery), 1 hr post operatively
| Intervention | score on a scale (Mean) | ||
|---|---|---|---|
| Preoperative VAS Pain Score | Immediate Post Op VAS Pain Score | 1 hr. Post Op VAS Pain Score | |
| Morphine With Clonidine | 2 | 3 | 4 |
| Normal Saline | 2 | 4 | 5 |
39 reviews available for clonidine and Pain, Postoperative
| Article | Year |
|---|---|
The Efficacy and Safety of Periarticular Injection in Total Joint Arthroplasty: A Direct Meta-Analysis.
Topics: Analgesics, Opioid; Anesthetics, Local; Arthroplasty, Replacement, Knee; Bupivacaine; Clonidine; Epi | 2022 |
Comparative Efficacy of Adjuvant Nonopioid Analgesia in Adult Cardiac Surgical Patients: A Network Meta-Analysis.
Topics: Adult; Analgesia; Analgesics; Analgesics, Non-Narcotic; Cardiac Surgical Procedures; Clonidine; Gaba | 2023 |
Strategies of analgesic treatment after cesarean delivery. Current state and new alternatives.
Topics: Acetaminophen; Analgesia, Obstetrical; Analgesics, Non-Narcotic; Analgesics, Opioid; Anesthesia, Epi | 2020 |
Clonidine for pain in non-ventilated infants.
Topics: Analgesics; Clonidine; Humans; Infant, Newborn; Pain, Postoperative; Pain, Procedural | 2020 |
What is the place of clonidine in anesthesia? Systematic review and meta-analyses of randomized controlled trials.
Topics: Adrenergic alpha-2 Receptor Agonists; Analgesics; Anesthesia; Clonidine; Heart; Hemodynamics; Humans | 2017 |
The impact of neuraxial clonidine on postoperative analgesia and perioperative adverse effects in women having elective Caesarean section-a systematic review and meta-analysis.
Topics: Adrenergic alpha-Agonists; Adult; Anesthesia, Conduction; Anesthesia, Obstetrical; Cesarean Section; | 2018 |
Safety and efficacy of clonidine on postoperative vomiting and pain in pediatric ophthalmic surgery: A systematic review and meta-analysis.
Topics: Analgesics; Antiemetics; Child; Clonidine; Humans; Pain, Postoperative; Postoperative Nausea and Vom | 2019 |
Chronic pain after childbirth.
Topics: Acute Pain; Adrenergic alpha-Agonists; Adult; Amines; Analgesics; Anesthetics, Dissociative; Cesarea | 2013 |
Intra-articular clonidine for post-operative analgesia following arthroscopic knee surgery: a systematic review and meta-analysis.
Topics: Adrenergic alpha-2 Receptor Agonists; Analgesics; Arthroscopy; Clonidine; Humans; Injections, Intra- | 2014 |
Clonidine premedication for postoperative analgesia in children.
Topics: Adrenergic alpha-2 Receptor Agonists; Analgesics; Child; Clonidine; Fentanyl; Humans; Midazolam; Pai | 2014 |
[Clonidine can reduce opioid medication during post-operative pain].
Topics: Analgesics; Analgesics, Opioid; Clonidine; Humans; Infusions, Intravenous; Pain, Postoperative | 2015 |
Analgesia in the surgical intensive care unit.
Topics: Acetaminophen; Amines; Analgesics; Analgesics, Opioid; Anesthesia, Conduction; Anesthetics, Local; C | 2017 |
Adjuncts to local anaesthetics in tonsillectomy: a systematic review and meta-analysis.
Topics: Anesthetics, Local; Clonidine; Dexamethasone; Humans; Laryngismus; Nerve Block; Pain, Postoperative; | 2017 |
Clonidine as an adjuvant to local anesthetics for peripheral nerve and plexus blocks: a meta-analysis of randomized trials.
Topics: Adjuvants, Anesthesia; Anesthetics, Local; Axilla; Clonidine; Humans; Motor Neurons; Nerve Block; Pa | 2009 |
Clonidine as an adjuvant to local anesthetics for peripheral nerve and plexus blocks: a meta-analysis of randomized trials.
Topics: Adjuvants, Anesthesia; Anesthetics, Local; Axilla; Clonidine; Humans; Motor Neurons; Nerve Block; Pa | 2009 |
Clonidine as an adjuvant to local anesthetics for peripheral nerve and plexus blocks: a meta-analysis of randomized trials.
Topics: Adjuvants, Anesthesia; Anesthetics, Local; Axilla; Clonidine; Humans; Motor Neurons; Nerve Block; Pa | 2009 |
Clonidine as an adjuvant to local anesthetics for peripheral nerve and plexus blocks: a meta-analysis of randomized trials.
Topics: Adjuvants, Anesthesia; Anesthetics, Local; Axilla; Clonidine; Humans; Motor Neurons; Nerve Block; Pa | 2009 |
Clonidine as an adjuvant to local anesthetics for peripheral nerve and plexus blocks: a meta-analysis of randomized trials.
Topics: Adjuvants, Anesthesia; Anesthetics, Local; Axilla; Clonidine; Humans; Motor Neurons; Nerve Block; Pa | 2009 |
Clonidine as an adjuvant to local anesthetics for peripheral nerve and plexus blocks: a meta-analysis of randomized trials.
Topics: Adjuvants, Anesthesia; Anesthetics, Local; Axilla; Clonidine; Humans; Motor Neurons; Nerve Block; Pa | 2009 |
Clonidine as an adjuvant to local anesthetics for peripheral nerve and plexus blocks: a meta-analysis of randomized trials.
Topics: Adjuvants, Anesthesia; Anesthetics, Local; Axilla; Clonidine; Humans; Motor Neurons; Nerve Block; Pa | 2009 |
Clonidine as an adjuvant to local anesthetics for peripheral nerve and plexus blocks: a meta-analysis of randomized trials.
Topics: Adjuvants, Anesthesia; Anesthetics, Local; Axilla; Clonidine; Humans; Motor Neurons; Nerve Block; Pa | 2009 |
Clonidine as an adjuvant to local anesthetics for peripheral nerve and plexus blocks: a meta-analysis of randomized trials.
Topics: Adjuvants, Anesthesia; Anesthetics, Local; Axilla; Clonidine; Humans; Motor Neurons; Nerve Block; Pa | 2009 |
Clonidine as an adjuvant to local anesthetics for peripheral nerve and plexus blocks: a meta-analysis of randomized trials.
Topics: Adjuvants, Anesthesia; Anesthetics, Local; Axilla; Clonidine; Humans; Motor Neurons; Nerve Block; Pa | 2009 |
Clonidine as an adjuvant to local anesthetics for peripheral nerve and plexus blocks: a meta-analysis of randomized trials.
Topics: Adjuvants, Anesthesia; Anesthetics, Local; Axilla; Clonidine; Humans; Motor Neurons; Nerve Block; Pa | 2009 |
Clonidine as an adjuvant to local anesthetics for peripheral nerve and plexus blocks: a meta-analysis of randomized trials.
Topics: Adjuvants, Anesthesia; Anesthetics, Local; Axilla; Clonidine; Humans; Motor Neurons; Nerve Block; Pa | 2009 |
Clonidine as an adjuvant to local anesthetics for peripheral nerve and plexus blocks: a meta-analysis of randomized trials.
Topics: Adjuvants, Anesthesia; Anesthetics, Local; Axilla; Clonidine; Humans; Motor Neurons; Nerve Block; Pa | 2009 |
Clonidine as an adjuvant to local anesthetics for peripheral nerve and plexus blocks: a meta-analysis of randomized trials.
Topics: Adjuvants, Anesthesia; Anesthetics, Local; Axilla; Clonidine; Humans; Motor Neurons; Nerve Block; Pa | 2009 |
Clonidine as an adjuvant to local anesthetics for peripheral nerve and plexus blocks: a meta-analysis of randomized trials.
Topics: Adjuvants, Anesthesia; Anesthetics, Local; Axilla; Clonidine; Humans; Motor Neurons; Nerve Block; Pa | 2009 |
Clonidine as an adjuvant to local anesthetics for peripheral nerve and plexus blocks: a meta-analysis of randomized trials.
Topics: Adjuvants, Anesthesia; Anesthetics, Local; Axilla; Clonidine; Humans; Motor Neurons; Nerve Block; Pa | 2009 |
Clonidine as an adjuvant to local anesthetics for peripheral nerve and plexus blocks: a meta-analysis of randomized trials.
Topics: Adjuvants, Anesthesia; Anesthetics, Local; Axilla; Clonidine; Humans; Motor Neurons; Nerve Block; Pa | 2009 |
Clonidine as an adjuvant to local anesthetics for peripheral nerve and plexus blocks: a meta-analysis of randomized trials.
Topics: Adjuvants, Anesthesia; Anesthetics, Local; Axilla; Clonidine; Humans; Motor Neurons; Nerve Block; Pa | 2009 |
Clonidine as an adjuvant to local anesthetics for peripheral nerve and plexus blocks: a meta-analysis of randomized trials.
Topics: Adjuvants, Anesthesia; Anesthetics, Local; Axilla; Clonidine; Humans; Motor Neurons; Nerve Block; Pa | 2009 |
Clonidine as an adjuvant to local anesthetics for peripheral nerve and plexus blocks: a meta-analysis of randomized trials.
Topics: Adjuvants, Anesthesia; Anesthetics, Local; Axilla; Clonidine; Humans; Motor Neurons; Nerve Block; Pa | 2009 |
Clonidine as an adjuvant to local anesthetics for peripheral nerve and plexus blocks: a meta-analysis of randomized trials.
Topics: Adjuvants, Anesthesia; Anesthetics, Local; Axilla; Clonidine; Humans; Motor Neurons; Nerve Block; Pa | 2009 |
Clonidine as an adjuvant to local anesthetics for peripheral nerve and plexus blocks: a meta-analysis of randomized trials.
Topics: Adjuvants, Anesthesia; Anesthetics, Local; Axilla; Clonidine; Humans; Motor Neurons; Nerve Block; Pa | 2009 |
Clonidine as an adjuvant to local anesthetics for peripheral nerve and plexus blocks: a meta-analysis of randomized trials.
Topics: Adjuvants, Anesthesia; Anesthetics, Local; Axilla; Clonidine; Humans; Motor Neurons; Nerve Block; Pa | 2009 |
Clonidine as an adjuvant to local anesthetics for peripheral nerve and plexus blocks: a meta-analysis of randomized trials.
Topics: Adjuvants, Anesthesia; Anesthetics, Local; Axilla; Clonidine; Humans; Motor Neurons; Nerve Block; Pa | 2009 |
Clonidine as an adjuvant to local anesthetics for peripheral nerve and plexus blocks: a meta-analysis of randomized trials.
Topics: Adjuvants, Anesthesia; Anesthetics, Local; Axilla; Clonidine; Humans; Motor Neurons; Nerve Block; Pa | 2009 |
Premedication with clonidine is superior to benzodiazepines. A meta analysis of published studies.
Topics: Adrenergic alpha-Agonists; Anesthesia Recovery Period; Benzodiazepines; Child; Child, Preschool; Clo | 2010 |
Topical application of analgesics: a clinical option in day case anaesthesia?
Topics: Administration, Topical; Ambulatory Surgical Procedures; Analgesia; Analgesics; Analgesics, Opioid; | 2010 |
Efficacy and safety of clonidine as additive for caudal regional anesthesia: a quantitative systematic review of randomized controlled trials.
Topics: Analgesics; Anesthesia, Caudal; Child; Clonidine; Humans; Pain, Postoperative; Postoperative Nausea | 2011 |
Bayesian enhanced meta-analysis of post-operative analgesic efficacy of additives for caudal analgesia in children.
Topics: Adjuvants, Anesthesia; Adolescent; Analgesics; Analgesics, Opioid; Anesthetics, Inhalation; Anesthet | 2012 |
Effect of perioperative systemic α2 agonists on postoperative morphine consumption and pain intensity: systematic review and meta-analysis of randomized controlled trials.
Topics: Adrenergic alpha-2 Receptor Agonists; Analgesics, Opioid; Anesthesia Recovery Period; Clonidine; Dex | 2012 |
Effect of perioperative systemic α2 agonists on postoperative morphine consumption and pain intensity: systematic review and meta-analysis of randomized controlled trials.
Topics: Adrenergic alpha-2 Receptor Agonists; Analgesics, Opioid; Anesthesia Recovery Period; Clonidine; Dex | 2012 |
Effect of perioperative systemic α2 agonists on postoperative morphine consumption and pain intensity: systematic review and meta-analysis of randomized controlled trials.
Topics: Adrenergic alpha-2 Receptor Agonists; Analgesics, Opioid; Anesthesia Recovery Period; Clonidine; Dex | 2012 |
Effect of perioperative systemic α2 agonists on postoperative morphine consumption and pain intensity: systematic review and meta-analysis of randomized controlled trials.
Topics: Adrenergic alpha-2 Receptor Agonists; Analgesics, Opioid; Anesthesia Recovery Period; Clonidine; Dex | 2012 |
Effect of perioperative systemic α2 agonists on postoperative morphine consumption and pain intensity: systematic review and meta-analysis of randomized controlled trials.
Topics: Adrenergic alpha-2 Receptor Agonists; Analgesics, Opioid; Anesthesia Recovery Period; Clonidine; Dex | 2012 |
Effect of perioperative systemic α2 agonists on postoperative morphine consumption and pain intensity: systematic review and meta-analysis of randomized controlled trials.
Topics: Adrenergic alpha-2 Receptor Agonists; Analgesics, Opioid; Anesthesia Recovery Period; Clonidine; Dex | 2012 |
Effect of perioperative systemic α2 agonists on postoperative morphine consumption and pain intensity: systematic review and meta-analysis of randomized controlled trials.
Topics: Adrenergic alpha-2 Receptor Agonists; Analgesics, Opioid; Anesthesia Recovery Period; Clonidine; Dex | 2012 |
Effect of perioperative systemic α2 agonists on postoperative morphine consumption and pain intensity: systematic review and meta-analysis of randomized controlled trials.
Topics: Adrenergic alpha-2 Receptor Agonists; Analgesics, Opioid; Anesthesia Recovery Period; Clonidine; Dex | 2012 |
Effect of perioperative systemic α2 agonists on postoperative morphine consumption and pain intensity: systematic review and meta-analysis of randomized controlled trials.
Topics: Adrenergic alpha-2 Receptor Agonists; Analgesics, Opioid; Anesthesia Recovery Period; Clonidine; Dex | 2012 |
Effect of perioperative systemic α2 agonists on postoperative morphine consumption and pain intensity: systematic review and meta-analysis of randomized controlled trials.
Topics: Adrenergic alpha-2 Receptor Agonists; Analgesics, Opioid; Anesthesia Recovery Period; Clonidine; Dex | 2012 |
Effect of perioperative systemic α2 agonists on postoperative morphine consumption and pain intensity: systematic review and meta-analysis of randomized controlled trials.
Topics: Adrenergic alpha-2 Receptor Agonists; Analgesics, Opioid; Anesthesia Recovery Period; Clonidine; Dex | 2012 |
Effect of perioperative systemic α2 agonists on postoperative morphine consumption and pain intensity: systematic review and meta-analysis of randomized controlled trials.
Topics: Adrenergic alpha-2 Receptor Agonists; Analgesics, Opioid; Anesthesia Recovery Period; Clonidine; Dex | 2012 |
Effect of perioperative systemic α2 agonists on postoperative morphine consumption and pain intensity: systematic review and meta-analysis of randomized controlled trials.
Topics: Adrenergic alpha-2 Receptor Agonists; Analgesics, Opioid; Anesthesia Recovery Period; Clonidine; Dex | 2012 |
Effect of perioperative systemic α2 agonists on postoperative morphine consumption and pain intensity: systematic review and meta-analysis of randomized controlled trials.
Topics: Adrenergic alpha-2 Receptor Agonists; Analgesics, Opioid; Anesthesia Recovery Period; Clonidine; Dex | 2012 |
Effect of perioperative systemic α2 agonists on postoperative morphine consumption and pain intensity: systematic review and meta-analysis of randomized controlled trials.
Topics: Adrenergic alpha-2 Receptor Agonists; Analgesics, Opioid; Anesthesia Recovery Period; Clonidine; Dex | 2012 |
Effect of perioperative systemic α2 agonists on postoperative morphine consumption and pain intensity: systematic review and meta-analysis of randomized controlled trials.
Topics: Adrenergic alpha-2 Receptor Agonists; Analgesics, Opioid; Anesthesia Recovery Period; Clonidine; Dex | 2012 |
[Pediatric caudal anesthesia: importance and aspects of safety concerns].
Topics: Adjuvants, Anesthesia; Anesthesia, Caudal; Anesthetics, Local; Blood Pressure; Child; Clonidine; Ele | 2012 |
Efficacy of adding clonidine to intrathecal morphine in acute postoperative pain: meta-analysis.
Topics: Acute Pain; Adrenergic alpha-Agonists; Analgesics, Opioid; Clonidine; Endpoint Determination; Fentan | 2013 |
[Postoperative pain therapy].
Topics: Acute Disease; Adrenergic alpha-Agonists; Analgesia; Analgesia, Patient-Controlled; Analgesics; Anal | 2003 |
Spinal agents for acute pain management.
Topics: Analgesia, Epidural; Analgesics; Analgesics, Opioid; Anesthetics, Local; Animals; Chronic Disease; C | 2004 |
Non-narcotic adjuvants may improve the duration and quality of analgesia after knee arthroscopy: a brief review.
Topics: Analgesia; Analgesics; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Arthroscop | 2004 |
[Efficacy of clonidine in paediatric anaesthesia].
Topics: Adjuvants, Anesthesia; Adrenergic alpha-Agonists; Anesthesia; Child; Clonidine; Humans; Pain, Postop | 2005 |
Postoperative pain management: can transdermal patches help?
Topics: Administration, Cutaneous; Analgesics; Anesthetics, Local; Antiemetics; Clonidine; Fentanyl; Humans; | 2006 |
The use of neuraxial adjuvant drugs (neostigmine, clonidine) in obstetrics.
Topics: Analgesia, Obstetrical; Analgesics; Cesarean Section; Cholinesterase Inhibitors; Clonidine; Female; | 2006 |
Clonidine and modification of perioperative outcome.
Topics: Adrenergic alpha-Agonists; Clonidine; Cost-Benefit Analysis; Humans; Pain, Postoperative; Perioperat | 2006 |
Intra-articular injections.
Topics: Acute Disease; Adrenal Cortex Hormones; Anesthetics, Local; Arthralgia; Chronic Disease; Clonidine; | 2007 |
Useful adjuvants for postoperative pain management.
Topics: Amines; Clonidine; Cyclohexanecarboxylic Acids; Dexamethasone; Excitatory Amino Acid Antagonists; Ga | 2007 |
Preventing the development of chronic pain after orthopaedic surgery with preventive multimodal analgesic techniques.
Topics: Acetaminophen; Adrenergic alpha-Agonists; Analgesia, Epidural; Analgesics; Anesthetics, Local; Anima | 2007 |
Alpha 2 adrenoceptor agonists and anaesthesia.
Topics: Adrenergic alpha-Agonists; Anesthesia, General; Anesthetics; Cardiovascular System; Central Nervous | 1993 |
[The role of clonidine in anesthesia].
Topics: Analgesics; Anesthesia; Clonidine; Ethanol; Humans; Hypnotics and Sedatives; Pain, Postoperative; Po | 1993 |
[Analgesia after surgery of the spine in adults and adolescents].
Topics: Adolescent; Adrenergic alpha-Agonists; Adult; Age Factors; Analgesia; Analgesics; Anti-Inflammatory | 1995 |
[Treatment of postoperative pain by balanced spinal analgesia].
Topics: Adrenergic alpha-Agonists; Analgesia; Analgesics, Opioid; Anesthetics, Local; Animals; Cats; Choline | 1995 |
The role of clonidine in anaesthesia.
Topics: Adrenergic alpha-Agonists; Analgesics; Anesthetics; Anesthetics, Combined; Clonidine; Humans; Pain, | 1998 |
[Use of clonidine for perioperative therapy].
Topics: Analgesics; Clonidine; Humans; Intraoperative Period; Pain, Postoperative; Postoperative Period; Pre | 1998 |
Meta-analysis of the efficacy of extradural clonidine to relieve postoperative pain: an impossible task.
Topics: Adrenergic alpha-Agonists; Analgesia, Epidural; Analgesics, Non-Narcotic; Clonidine; Drug Administra | 1998 |
Clonidine: old friend--new guises.
Topics: Analgesics; Anesthetics; Cardiovascular System; Chronic Disease; Clonidine; Drug Synergism; Humans; | 1990 |
254 trials available for clonidine and Pain, Postoperative
| Article | Year |
|---|---|
Day-One Pain Reductions After Hip and Knee Replacement When Buprenorphine-Clonidine-Dexamethasone Is Added to Bupivacaine Nerve/Plexus Blocks: A Randomized Clinical Trial.
Topics: Anesthetics, Local; Bupivacaine; Buprenorphine; Clonidine; Dexamethasone; Double-Blind Method; Human | 2022 |
Spinal anaesthesia with clonidine: pain relief and earlier mobilisation after open nephrectomy - a randomised clinical trial.
Topics: Analgesia, Epidural; Anesthesia, Spinal; Clonidine; Early Ambulation; Humans; Kidney Neoplasms; Neph | 2022 |
The efficacy and safety of an adapted opioid-free anesthesia regimen versus conventional general anesthesia in gynecological surgery for low-resource settings: a randomized pilot study.
Topics: Analgesics, Opioid; Anesthesia, General; Clonidine; Dexamethasone; Dexmedetomidine; Diazepam; Female | 2022 |
Comparison of the effect of scalp block analgesia bupivacaine 0.25% and clonidine 2 μg/kg with bupivacaine 0.25% and dexamethasone 8 mg on cortisol levels and Numeric Rating Scale in craniotomy tumour.
Topics: Analgesia; Anesthetics, Local; Bupivacaine; Clonidine; Craniotomy; Dexamethasone; Humans; Hydrocorti | 2023 |
The effect of clonidine added to ropivacaine on opioid consumption in transverse abdominis plane blocks for cesarean section: A randomized, double-blind, placebo-controlled, pilot trial.
Topics: Abdominal Muscles; Amides; Analgesics, Opioid; Anesthetics, Local; Cesarean Section; Clonidine; Doub | 2020 |
Effects of adding a combined femoral and sciatic nerve block with levobupivacaine and clonidine to general anaesthesia in femoropopliteal bypass surgery: A randomised, double-blind, controlled trial.
Topics: Adult; Analgesics, Opioid; Anesthesia, General; Anesthetics, Local; Clonidine; Double-Blind Method; | 2020 |
Extended Perineural Analgesia After Hip and Knee Replacement When Buprenorphine-Clonidine-Dexamethasone Is Added to Bupivacaine: Preliminary Report from a Randomized Clinical Trial.
Topics: Analgesia; Anesthetics, Local; Bupivacaine; Buprenorphine; Clonidine; Dexamethasone; Double-Blind Me | 2020 |
Clonidine as an Adjuvant to Bupivacaine for Suprazygomatic Maxillary Nerve Blocks in Cleft lip and Palate Repair: A Randomized, Prospective, Double-Blind Study.
Topics: Aged; Anesthetics, Local; Bupivacaine; Child; Child, Preschool; Cleft Lip; Cleft Palate; Clonidine; | 2021 |
Dexmedetomidine versus clonidine adjuvants to levobupivacaine for ultrasound-guided transversus abdominis plane block in paediatric laparoscopic orchiopexy: Randomized, double-blind study.
Topics: Abdominal Muscles; Anesthetics, Local; Child; Clonidine; Dexmedetomidine; Double-Blind Method; Human | 2021 |
The addition of clonidine to ropivacaine in rectus sheath nerve blocks for pediatric patients undergoing laparoscopic appendectomy: A double blinded randomized prospective study.
Topics: Adolescent; Amides; Anesthetics, Local; Appendectomy; Child; Clonidine; Double-Blind Method; Humans; | 2021 |
Spinal analgesia improves surgical outcome after open nephrectomy for renal cell carcinoma: a randomized controlled study.
Topics: Adult; Aged; Aged, 80 and over; Analgesia, Epidural; Analgesics; Carcinoma, Renal Cell; Clonidine; E | 2017 |
Clonidine, but not Dexamethasone, Prolongs Ropivacaine-Induced Supraclavicular Brachial Plexus Nerve Block Duration.
Topics: Adult; Aged; Analgesics; Anesthetics, Local; Brachial Plexus Block; Clonidine; Dexamethasone; Drug T | 2017 |
Bupivacaine Field Block With Clonidine for Postoperative Pain Control in Posterior Spine Approaches: A Randomized Double-Blind Trial.
Topics: Adult; Anesthetics, Local; Bupivacaine; Clonidine; Diskectomy; Double-Blind Method; Female; Humans; | 2018 |
Ultrasound-guided bilateral superficial cervical block and preemptive single-dose oral tizanidine for post-thyroidectomy pain: a randomized-controlled double-blind study.
Topics: Adult; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Anesthesia, General; Anestheti | 2018 |
Clonidine Effect on Pain After Cesarean Delivery: A Randomized Controlled Trial of Different Routes of Administration.
Topics: Adrenergic alpha-2 Receptor Agonists; Adult; Analgesia, Obstetrical; Anesthesia, Obstetrical; Anesth | 2018 |
Periarticular Ropivacaine Cocktail Is Equivalent to Liposomal Bupivacaine Cocktail in Bilateral Total Knee Arthroplasty.
Topics: Adult; Aged; Anesthetics, Local; Arthroplasty, Replacement, Knee; Bupivacaine; Clonidine; Double-Bli | 2018 |
Single-Injection Adductor Canal Block With Multiple Adjuvants Provides Equivalent Analgesia When Compared With Continuous Adductor Canal Blockade for Primary Total Knee Arthroplasty: A Double-Blinded, Randomized, Controlled, Equivalency Trial.
Topics: Aged; Analgesia; Anesthetics, Local; Arthroplasty, Replacement, Knee; Bupivacaine; Buprenorphine; Ca | 2018 |
Comparison of Ondansetron versus Clonidine efficacy for prevention of postoperative pain, nausea and vomiting after orthognathic surgeries: A triple blind randomized controlled trial.
Topics: Adolescent; Adult; Analgesics; Antiemetics; Clonidine; Double-Blind Method; Female; Humans; Male; On | 2018 |
Adductor Canal Nerve Versus Femoral Nerve Blockade for Pain Control and Quadriceps Function Following Anterior Cruciate Ligament Reconstruction With Patellar Tendon Autograft: A Prospective Randomized Trial.
Topics: Adolescent; Adult; Analgesics; Analysis of Variance; Anesthesia, Conduction; Anterior Cruciate Ligam | 2019 |
Effect of intrathecal morphine and epidural analgesia on postoperative recovery after abdominal surgery for gynecologic malignancy: an open-label randomised trial.
Topics: Aged; Analgesics, Opioid; Anesthesia, Epidural; Clonidine; Enhanced Recovery After Surgery; Female; | 2019 |
The impact of a transversus abdominis plane block including clonidine vs. intrathecal morphine on nausea and vomiting after caesarean section: A randomised controlled trial.
Topics: Abdominal Muscles; Adult; Anesthesia, Obstetrical; Anesthesia, Spinal; Anesthetics, Local; Cesarean | 2019 |
Comparison of Single-Agent Versus 3-Additive Regional Anesthesia for Foot and Ankle Surgery.
Topics: Anesthetics; Ankle; Bupivacaine; Buprenorphine; Clonidine; Dexamethasone; Double-Blind Method; Femal | 2019 |
Efficacy of multimodal perioperative analgesia protocol with periarticular medication injection in total knee arthroplasty: a randomized, double-blinded study.
Topics: Adult; Aged; Aged, 80 and over; Amides; Analgesics; Arthroplasty, Replacement, Knee; Clonidine; Doub | 2013 |
Efficacy of multimodal perioperative analgesia protocol with periarticular medication injection in total knee arthroplasty: a randomized, double-blinded study.
Topics: Adult; Aged; Aged, 80 and over; Amides; Analgesics; Arthroplasty, Replacement, Knee; Clonidine; Doub | 2013 |
Efficacy of multimodal perioperative analgesia protocol with periarticular medication injection in total knee arthroplasty: a randomized, double-blinded study.
Topics: Adult; Aged; Aged, 80 and over; Amides; Analgesics; Arthroplasty, Replacement, Knee; Clonidine; Doub | 2013 |
Efficacy of multimodal perioperative analgesia protocol with periarticular medication injection in total knee arthroplasty: a randomized, double-blinded study.
Topics: Adult; Aged; Aged, 80 and over; Amides; Analgesics; Arthroplasty, Replacement, Knee; Clonidine; Doub | 2013 |
Guided paravertebral blocks with versus without clonidine for women undergoing breast surgery: a prospective double-blinded randomized study.
Topics: Breast Neoplasms; Clonidine; Double-Blind Method; Female; Humans; Mastectomy; Middle Aged; Monitorin | 2013 |
Postoperative analgesic effect of intravenous (i.v.) clonidine compared with clonidine administration in wound infiltration for open cholecystectomy.
Topics: Adolescent; Adult; Aged; Analgesics, Non-Narcotic; Analgesics, Opioid; Anesthetics, Intravenous; Bup | 2013 |
Combination of oral clonidine and intravenous low-dose ketamine reduces the consumption of postoperative patient-controlled analgesia morphine after spine surgery.
Topics: Administration, Oral; Adult; Aged; Analgesia, Patient-Controlled; Clonidine; Drug Therapy, Combinati | 2013 |
Supplemental single shot femoral nerve block for total hip arthroplasty: impact on early postoperative care, pain management and lung function.
Topics: Aged; Anesthesia Recovery Period; Anesthetics, Local; Arthroplasty, Replacement, Hip; Bupivacaine; C | 2014 |
Epidural anesthesia with ropivacaine with or without clonidine and postoperative pain in hemorrhoidectomies.
Topics: Adrenergic alpha-2 Receptor Agonists; Adult; Age Factors; Aged; Amides; Anesthesia, Epidural; Anesth | 2014 |
Clonidine as an adjuvant to prolong local analgesia in conventional scleral buckle surgery.
Topics: Adult; Aged; Analgesics; Anesthetics, Local; Blood Pressure; Bupivacaine; Clonidine; Cryotherapy; Do | 2014 |
A Randomised Controlled Trial to Evaluate the Effectiveness of Intrathecal Bupivacaine Combined with Different Adjuvants (Fentanyl, Clonidine and Dexmedetomidine) in Caesarean Section.
Topics: Adjuvants, Anesthesia; Adult; Anesthesia, Obstetrical; Anesthesia, Spinal; Anesthetics, Local; Bupiv | 2015 |
[Pudendal nerve block for perineo-vulvar surgery: monocentered prospective and randomised study].
Topics: Amides; Analgesics; Anesthesia, General; Anesthetics, Local; Clonidine; Female; Gynecologic Surgical | 2015 |
Patient-controlled epidural analgesia or multimodal pain regimen with periarticular injection after total hip arthroplasty: a randomized, double-blind, placebo-controlled study.
Topics: Administration, Cutaneous; Aged; Aged, 80 and over; Analgesia, Epidural; Analgesia, Patient-Controll | 2015 |
Influence on intraocular pressure of anti-inflammatory treatments after selective laser trabeculoplasty.
Topics: Aged; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Clonidine; Combined Modalit | 2015 |
Comparison of lumbar epidural bupivacaine with fentanyl or clonidine for postoperative analgesia in children with cerebral palsy after single-event multilevel surgery.
Topics: Analgesics; Bupivacaine; Cerebral Palsy; Child; Clonidine; Drug Therapy, Combination; Female; Fentan | 2016 |
Comparison of fentanyl versus meperidine as supplements to epidural clonidine-bupivacaine in patients with lower limb orthopedic surgery under combined spinal epidural anesthesia.
Topics: Adult; Aged; Anesthesia, Epidural; Anesthesia, Spinal; Bupivacaine; Clonidine; Drug Therapy, Combina | 2015 |
Periarticular Injection After Total Knee Arthroplasty Using Liposomal Bupivacaine vs a Modified Ranawat Suspension: A Prospective, Randomized Study.
Topics: Aged; Amides; Analgesics; Arthroplasty, Replacement, Knee; Bupivacaine; Clonidine; Epinephrine; Fema | 2016 |
Tizanidine for the management of acute postoperative pain after inguinal hernia repair: A placebo-controlled double-blind trial.
Topics: Acute Pain; Adult; Aged; Analgesics; Clonidine; Double-Blind Method; Female; Hernia, Inguinal; Herni | 2016 |
Tizanidine for the management of acute postoperative pain after inguinal hernia repair: A placebo-controlled double-blind trial.
Topics: Acute Pain; Adult; Aged; Analgesics; Clonidine; Double-Blind Method; Female; Hernia, Inguinal; Herni | 2016 |
Tizanidine for the management of acute postoperative pain after inguinal hernia repair: A placebo-controlled double-blind trial.
Topics: Acute Pain; Adult; Aged; Analgesics; Clonidine; Double-Blind Method; Female; Hernia, Inguinal; Herni | 2016 |
Tizanidine for the management of acute postoperative pain after inguinal hernia repair: A placebo-controlled double-blind trial.
Topics: Acute Pain; Adult; Aged; Analgesics; Clonidine; Double-Blind Method; Female; Hernia, Inguinal; Herni | 2016 |
The addition of clonidine to bupivacaine in saphenous/sciatic nerve blocks in children.
Topics: Analgesics; Anesthetics, Local; Bupivacaine; Child; Child, Preschool; Clonidine; Double-Blind Method | 2016 |
Buprenorphine, Clonidine, Dexamethasone, and Ropivacaine for Interscalene Nerve Blockade: A Prospective, Randomized, Blinded, Ropivacaine Dose-Response Study.
Topics: Aged; Amides; Anesthetics, Local; Anti-Inflammatory Agents; Buprenorphine; Clonidine; Dexamethasone; | 2016 |
Buprenorphine, Clonidine, Dexamethasone, and Ropivacaine for Interscalene Nerve Blockade: A Prospective, Randomized, Blinded, Ropivacaine Dose-Response Study.
Topics: Aged; Amides; Anesthetics, Local; Anti-Inflammatory Agents; Buprenorphine; Clonidine; Dexamethasone; | 2016 |
Buprenorphine, Clonidine, Dexamethasone, and Ropivacaine for Interscalene Nerve Blockade: A Prospective, Randomized, Blinded, Ropivacaine Dose-Response Study.
Topics: Aged; Amides; Anesthetics, Local; Anti-Inflammatory Agents; Buprenorphine; Clonidine; Dexamethasone; | 2016 |
Buprenorphine, Clonidine, Dexamethasone, and Ropivacaine for Interscalene Nerve Blockade: A Prospective, Randomized, Blinded, Ropivacaine Dose-Response Study.
Topics: Aged; Amides; Anesthetics, Local; Anti-Inflammatory Agents; Buprenorphine; Clonidine; Dexamethasone; | 2016 |
Buprenorphine, Clonidine, Dexamethasone, and Ropivacaine for Interscalene Nerve Blockade: A Prospective, Randomized, Blinded, Ropivacaine Dose-Response Study.
Topics: Aged; Amides; Anesthetics, Local; Anti-Inflammatory Agents; Buprenorphine; Clonidine; Dexamethasone; | 2016 |
Buprenorphine, Clonidine, Dexamethasone, and Ropivacaine for Interscalene Nerve Blockade: A Prospective, Randomized, Blinded, Ropivacaine Dose-Response Study.
Topics: Aged; Amides; Anesthetics, Local; Anti-Inflammatory Agents; Buprenorphine; Clonidine; Dexamethasone; | 2016 |
Buprenorphine, Clonidine, Dexamethasone, and Ropivacaine for Interscalene Nerve Blockade: A Prospective, Randomized, Blinded, Ropivacaine Dose-Response Study.
Topics: Aged; Amides; Anesthetics, Local; Anti-Inflammatory Agents; Buprenorphine; Clonidine; Dexamethasone; | 2016 |
Buprenorphine, Clonidine, Dexamethasone, and Ropivacaine for Interscalene Nerve Blockade: A Prospective, Randomized, Blinded, Ropivacaine Dose-Response Study.
Topics: Aged; Amides; Anesthetics, Local; Anti-Inflammatory Agents; Buprenorphine; Clonidine; Dexamethasone; | 2016 |
Buprenorphine, Clonidine, Dexamethasone, and Ropivacaine for Interscalene Nerve Blockade: A Prospective, Randomized, Blinded, Ropivacaine Dose-Response Study.
Topics: Aged; Amides; Anesthetics, Local; Anti-Inflammatory Agents; Buprenorphine; Clonidine; Dexamethasone; | 2016 |
Is There a Benefit for Liposomal Bupivacaine Compared to a Traditional Periarticular Injection in Total Knee Arthroplasty Patients With a History of Chronic Opioid Use?
Topics: Aged; Amides; Analgesics, Opioid; Anesthetics, Local; Arthroplasty, Replacement, Knee; Bupivacaine; | 2016 |
The analgesic effect of clonidine as an adjuvant in dorsal penile nerve block.
Topics: Analgesics; Anesthetics, Local; Bupivacaine; Child, Preschool; Circumcision, Male; Clonidine; Double | 2016 |
Clonidine and ketamine for stable hemodynamics in off-pump coronary artery bypass.
Topics: Adrenergic alpha-2 Receptor Agonists; Aged; Airway Extubation; Analgesics, Opioid; Anesthetics, Diss | 2016 |
Clonidine Does Not Reduce Pain or Opioid Consumption After Noncardiac Surgery.
Topics: Adrenergic alpha-2 Receptor Agonists; Aged; Analgesics; Analgesics, Opioid; Clonidine; Cross-Over St | 2016 |
Randomized study of postcesarean analgesia with intrathecal morphine alone or combined with clonidine.
Topics: Adrenergic alpha-Agonists; Adult; Analgesics, Opioid; Cesarean Section; Clonidine; Double-Blind Meth | 2016 |
Postoperative analgesia with dexmedetomidine in interscalene block. Comparative study.
Topics: Adolescent; Adrenergic alpha-2 Receptor Agonists; Adult; Aged; Amides; Analgesia; Analgesics; Anesth | 2017 |
Postoperative analgesia in children when using clonidine in addition to fentanyl with bupivacaine given caudally.
Topics: Analgesics; Anesthesia, Epidural; Anesthesia, General; Anesthetics, Local; Bupivacaine; Child, Presc | 2016 |
[Peridural application of ropivacaine and clonidine for pain therapy after prostatectomy].
Topics: Amides; Analgesics; Anesthetics, Local; Antiemetics; Clonidine; Histamine Antagonists; Humans; Male; | 2008 |
Intra-articular sufentanil in multimodal analgesic management after outpatient arthroscopic anterior cruciate ligament reconstruction: a prospective, randomized, double-blinded study.
Topics: Adolescent; Adult; Ambulatory Surgical Procedures; Amides; Analgesics; Analgesics, Opioid; Anestheti | 2008 |
An evaluation of the postoperative antihyperalgesic and analgesic effects of intrathecal clonidine administered during elective cesarean delivery.
Topics: Adult; Analgesia, Obstetrical; Analgesics; Anesthesia, Spinal; Anesthetics, Intravenous; Anesthetics | 2008 |
Preoperative anxiolytic effect of melatonin and clonidine on postoperative pain and morphine consumption in patients undergoing abdominal hysterectomy: a double-blind, randomized, placebo-controlled study.
Topics: Administration, Oral; Adult; Analgesics; Analgesics, Opioid; Analysis of Variance; Anxiety; Central | 2009 |
Preoperative anxiolytic effect of melatonin and clonidine on postoperative pain and morphine consumption in patients undergoing abdominal hysterectomy: a double-blind, randomized, placebo-controlled study.
Topics: Administration, Oral; Adult; Analgesics; Analgesics, Opioid; Analysis of Variance; Anxiety; Central | 2009 |
Preoperative anxiolytic effect of melatonin and clonidine on postoperative pain and morphine consumption in patients undergoing abdominal hysterectomy: a double-blind, randomized, placebo-controlled study.
Topics: Administration, Oral; Adult; Analgesics; Analgesics, Opioid; Analysis of Variance; Anxiety; Central | 2009 |
Preoperative anxiolytic effect of melatonin and clonidine on postoperative pain and morphine consumption in patients undergoing abdominal hysterectomy: a double-blind, randomized, placebo-controlled study.
Topics: Administration, Oral; Adult; Analgesics; Analgesics, Opioid; Analysis of Variance; Anxiety; Central | 2009 |
The analgesic effect of epidural clonidine after spinal surgery: a randomized placebo-controlled trial.
Topics: Adrenergic alpha-Agonists; Adult; Aged; Analgesia, Epidural; Blood Pressure; Clonidine; Double-Blind | 2009 |
Adjuvant therapy with intrathecal clonidine improves postoperative pain in patients undergoing coronary artery bypass graft.
Topics: Aged; Analgesics; Chemotherapy, Adjuvant; Clonidine; Coronary Artery Bypass; Female; Hemodynamics; H | 2009 |
The efficacy of intrathecal morphine with or without clonidine for postoperative analgesia after radical prostatectomy.
Topics: Adrenergic alpha-Agonists; Aged; Analgesics, Opioid; Anesthesia, General; Clonidine; Drug Therapy, C | 2009 |
Addition of clonidine or dexmedetomidine to bupivacaine prolongs caudal analgesia in children.
Topics: Abdomen; Analgesia, Epidural; Analgesics, Non-Narcotic; Anesthesia, Inhalation; Anesthetics, Local; | 2009 |
Preoperative clonidine or levobupivacaine--effect on systemic inflammatory stress response.
Topics: Adrenergic alpha-Agonists; Analgesia, Epidural; Anesthetics, Local; Biomarkers; Bupivacaine; Clonidi | 2009 |
Postoperative pain and systemic inflammatory stress response after preoperative analgesia with clonidine or levobupivacaine: a randomized controlled trial.
Topics: Aged; Analgesics; Anesthetics, Local; Bupivacaine; Clonidine; Female; Humans; Levobupivacaine; Male; | 2009 |
The effects of caudal or intravenous clonidine on postoperative analgesia produced by caudal levobupivacaine in children.
Topics: Analgesics; Anesthesia, Caudal; Anesthetics, Combined; Anesthetics, Local; Bupivacaine; Child; Child | 2010 |
Randomized controlled trial comparing morphine or clonidine with bupivacaine for caudal analgesia in children undergoing upper abdominal surgery.
Topics: Abdomen; Analgesia, Epidural; Analgesics, Opioid; Anesthesia, Caudal; Bupivacaine; Child; Child, Pre | 2011 |
Postoperatve pain relief in children after subumbilical surgeries-a comparison between caudal bupivacaine and bupivacaine-clonidine.
Topics: Anesthesia, Caudal; Anesthetics, Local; Bupivacaine; Case-Control Studies; Child; Child, Preschool; | 2011 |
An evaluation of intrathecal bupivacaine combined with intrathecal or intravenous clonidine in children undergoing orthopedic surgery: a randomized double-blinded study.
Topics: Adrenergic alpha-Agonists; Anesthesia, Spinal; Anesthetics, Intravenous; Anesthetics, Local; Arthrop | 2011 |
Comparison of clonidine, local anesthetics, and placebo for pain reduction in pediatric tonsillectomy.
Topics: Adenoids; Adolescent; Age Factors; Analgesics; Anesthetics, Local; Bupivacaine; Child; Child, Presch | 2011 |
A comparative clinical study of injection clonidine versus midazolam in supraclavicular brachial plexus block for sedation and postoperative analgesia: a study of 60 cases.
Topics: Adult; Analgesia; Analgesics; Brachial Plexus; Bupivacaine; Clonidine; Conscious Sedation; Female; H | 2010 |
[Clonidine for remifentanil-induced hyperalgesia: a double-blind randomized, placebo-controlled study of clonidine under intra-operative use of remifentanil in elective surgery of the shoulder].
Topics: Adult; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Anesthetics, Intravenous; Arth | 2011 |
Epidural steroid and clonidine for chronic intractable post-thoracotomy pain: a pilot study.
Topics: Adult; Analgesics; Clonidine; Female; Humans; Injections, Epidural; Male; Methylprednisolone; Pain M | 2012 |
Supplementation of retrobulbar block with clonidine in vitreoretinal surgery: effect on postoperative pain.
Topics: Aged; Anesthetics, Combined; Anesthetics, Local; Bupivacaine; Clonidine; Double-Blind Method; Female | 2011 |
Low-dose intravenous ketamine and clonidine for poor postoperative opioid responsiveness: a double blind randomized study.
Topics: Analgesics; Analgesics, Opioid; Clonidine; Dose-Response Relationship, Drug; Double-Blind Method; Dr | 2011 |
Is clonidine an adequate alternative to epinephrine as a vasoconstrictor in patients with hypertension?
Topics: Adult; Analgesics, Non-Narcotic; Anesthetics, Local; Antihypertensive Agents; Arrhythmias, Cardiac; | 2012 |
Caudal bupivacaine supplemented with morphine or clonidine, or supplemented with morphine plus clonidine in children undergoing infra-umbilical urological and genital procedures: a prospective, randomized and double-blind study.
Topics: Analgesics; Anesthesia, Caudal; Anesthesia, General; Anesthetics, Local; Bupivacaine; Child; Child, | 2012 |
Caudal bupivacaine supplemented with morphine or clonidine, or supplemented with morphine plus clonidine in children undergoing infra-umbilical urological and genital procedures: a prospective, randomized and double-blind study.
Topics: Analgesics; Anesthesia, Caudal; Anesthesia, General; Anesthetics, Local; Bupivacaine; Child; Child, | 2012 |
Caudal bupivacaine supplemented with morphine or clonidine, or supplemented with morphine plus clonidine in children undergoing infra-umbilical urological and genital procedures: a prospective, randomized and double-blind study.
Topics: Analgesics; Anesthesia, Caudal; Anesthesia, General; Anesthetics, Local; Bupivacaine; Child; Child, | 2012 |
Caudal bupivacaine supplemented with morphine or clonidine, or supplemented with morphine plus clonidine in children undergoing infra-umbilical urological and genital procedures: a prospective, randomized and double-blind study.
Topics: Analgesics; Anesthesia, Caudal; Anesthesia, General; Anesthetics, Local; Bupivacaine; Child; Child, | 2012 |
A comparative study of duration of postoperative analgesia between epidural bupivacaine and epidural clonidine plus bupivacaine in lumbar laminectomy surgery under general anaesthesia.
Topics: Adult; Aged; Analgesia, Epidural; Anesthesia, General; Anesthetics, Local; Bupivacaine; Clonidine; D | 2011 |
Clonidine does not improve quality of ropivacaine axillary brachial plexus block in children.
Topics: Adjuvants, Anesthesia; Amides; Anesthetics, Local; Blood Pressure; Brachial Plexus; Child; Child, Pr | 2012 |
Comparison between ropivacaine 1.5 mg ml(-1) plus fentanyl 2 mg ml(-1) and ropivacaine 1.5 mg ml(-1) plus clonidine 1 mg ml(-1) as analgesic solution after anterior cruciate ligament reconstruction: a randomized clinical trial.
Topics: Adrenergic alpha-Agonists; Adult; Amides; Anesthetics, Intravenous; Anesthetics, Local; Anterior Cru | 2011 |
Does epidural clonidine improve postoperative analgesia in major vascular surgery?
Topics: Analgesia, Epidural; Analgesics; Analgesics, Opioid; Anesthetics, Local; Aorta; Blood Pressure; Bupi | 2012 |
Randomized controlled trial on the efficacy of bilateral superficial cervical plexus block in thyroidectomy.
Topics: Adult; Analgesics; Anesthetics, Local; Bupivacaine; Cervical Plexus; Clonidine; Double-Blind Method; | 2013 |
Spinal anesthesia for elective ceasarean section: use of different doses of hyperbaric bupivacaine associated with morphine and clonidine.
Topics: Adjuvants, Anesthesia; Adrenergic alpha-2 Receptor Agonists; Adult; Analgesics, Opioid; Anesthesia, | 2013 |
The analgesic effect of intrathecal dexmedetomidine or clonidine, with bupivacaine, in trauma patients undergoing lower limb surgery: a randomised, double-blind study.
Topics: Adolescent; Adult; Aged; Analgesics; Analgesics, Non-Narcotic; Anesthetics, Local; Bupivacaine; Clon | 2013 |
Effect of the addition of clonidine to locally administered bupivacaine on acute and chronic postmastectomy pain.
Topics: Acute Pain; Administration, Topical; Adult; Analgesics; Anesthetics, Local; Breast Neoplasms; Bupiva | 2013 |
Postoperative pain relief following intrathecal bupivacaine combined with intrathecal or oral clonidine.
Topics: Administration, Oral; Adrenergic alpha-Agonists; Adult; Analgesics; Anesthesia, Spinal; Anesthetics, | 2002 |
Comparison of caudal and intravenous clonidine in the prevention of agitation after sevoflurane in children.
Topics: Adrenergic alpha-Agonists; Akathisia, Drug-Induced; Analgesics; Anesthetics, Inhalation; Child; Chil | 2002 |
Anaesthetic and postoperative analgesic effects of spinal clonidine as an additive to prilocaine in the transurethral resection of urinary bladder tumours.
Topics: Aged; Aged, 80 and over; Analgesics; Anesthesia, Spinal; Anesthetics, Combined; Anesthetics, Local; | 2002 |
Analgesia for paediatric tonsillectomy and adenoidectomy with intramuscular clonidine.
Topics: Acetaminophen; Adenoidectomy; Administration, Rectal; Adrenergic alpha-Agonists; Ambulatory Surgical | 2002 |
Epinephrine and clonidine do not improve intrathecal sufentanil analgesia after total hip replacement.
Topics: Aged; Aged, 80 and over; Analgesics; Analgesics, Opioid; Arthroplasty, Replacement, Hip; Blood Press | 2002 |
Comparison of morphine alone with morphine plus clonidine for postoperative patient-controlled analgesia.
Topics: Abdomen; Adult; Aged; Analgesia, Patient-Controlled; Analgesics; Clonidine; Double-Blind Method; Dru | 2002 |
Spinal versus peripheral effects of adjunct clonidine: comparison of the analgesic effect of a ropivacaine-clonidine mixture when administered as a caudal or ilioinguinal-iliohypogastric nerve blockade for inguinal surgery in children.
Topics: Amides; Analgesia; Anesthesia, Caudal; Anesthetics, Combined; Anesthetics, Local; Child; Child, Pres | 2002 |
The addition of droperidol or clonidine to epidural tramadol shortens onset time and increases duration of postoperative analgesia.
Topics: Abdomen; Adjuvants, Anesthesia; Adrenergic alpha-Agonists; Adult; Aged; Analgesia, Epidural; Analges | 2003 |
Intrathecal morphine and clonidine for coronary artery bypass grafting.
Topics: Adult; Aged; Aged, 80 and over; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Cloni | 2003 |
Oral clonidine premedication preserves heart rate variability for patients undergoing larparoscopic cholecystectomy.
Topics: Adrenergic alpha-Agonists; Adult; Anesthesia, General; Cholecystectomy, Laparoscopic; Clonidine; Dou | 2003 |
Intrathecal clonidine added to a bupivacaine-morphine spinal anesthetic improves postoperative analgesia for total knee arthroplasty.
Topics: Adrenergic alpha-Agonists; Aged; Analgesia, Patient-Controlled; Analgesics, Opioid; Anesthesia, Spin | 2003 |
Clonidine combined with small-dose bupivacaine during spinal anesthesia for inguinal herniorrhaphy: a randomized double-blinded study.
Topics: Adrenergic alpha-Agonists; Adult; Anesthesia, General; Anesthesia, Spinal; Anesthetics, Local; Bupiv | 2003 |
Side-effects of postoperative epidural analgesia in children: a randomized study comparing morphine and clonidine.
Topics: Abdomen; Analgesia, Epidural; Analgesics; Analgesics, Opioid; Child; Child, Preschool; Clonidine; Do | 2003 |
Transdermal clonidine: does it affect pain after abdominal hysterectomy?
Topics: Administration, Cutaneous; Adrenergic alpha-Agonists; Adult; Analgesics, Opioid; Anesthesia, Inhalat | 2003 |
[Comparison of premedication with clonidine and midazolam combined with TCI for orthopaedic shoulder surgery].
Topics: Adolescent; Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-Agonists; Adult; Aged; Analgesia, | 2003 |
Epidural infusion of clonidine or clonidine plus ropivacaine for postoperative analgesia in children undergoing major abdominal surgery.
Topics: Abdomen; Adrenergic alpha-Agonists; Amides; Analgesia, Epidural; Analgesics, Opioid; Anesthetics, Lo | 2003 |
Caudal bupivacaine supplemented with caudal or intravenous clonidine in children undergoing hypospadias repair: a double-blind study.
Topics: Adrenergic alpha-Agonists; Analgesia, Epidural; Analgesics; Analgesics, Opioid; Anesthetics, Local; | 2004 |
The addition of sufentanil, tramadol or clonidine to lignocaine for intravenous regional anaesthesia.
Topics: Adrenergic alpha-Agonists; Adult; Analgesics, Opioid; Anesthesia, Conduction; Anesthetics, Combined; | 2004 |
Postcesarean analgesia with spinal morphine, clonidine, or their combination.
Topics: Adrenergic alpha-Agonists; Adult; Analgesia, Patient-Controlled; Analgesics, Opioid; Anti-Inflammato | 2004 |
Analgesic effect of clonidine added to bupivacaine 0.125% in paediatric caudal blockade.
Topics: Adrenergic alpha-Agonists; Analgesics; Anesthesia, Caudal; Anesthetics, Local; Bupivacaine; Child, P | 2004 |
General anaesthesia combined with bilateral paravertebral blockade (T5-6) vs. general anaesthesia for laparoscopic cholecystectomy: a prospective, randomized clinical trial.
Topics: Analgesics; Analgesics, Opioid; Anesthesia, General; Anesthetics, Local; Bupivacaine; Cholecystectom | 2004 |
The effect of epidural clonidine on perioperative cytokine response, postoperative pain, and bowel function in patients undergoing colorectal surgery.
Topics: Adrenergic alpha-Agonists; Adult; Aged; Analgesia, Epidural; Analgesia, Patient-Controlled; Analgesi | 2004 |
Intrathecal clonidine for postoperative analgesia in elderly patients: the influence of baricity on hemodynamic and analgesic effects.
Topics: Adrenergic alpha-Agonists; Aged; Blood Pressure; Clonidine; Double-Blind Method; Female; Heart Rate; | 2004 |
The addition of clonidine to bupivacaine in combined femoral-sciatic nerve block for anterior cruciate ligament reconstruction.
Topics: Adult; Analgesics; Anesthetics, Local; Anterior Cruciate Ligament; Anterior Cruciate Ligament Injuri | 2004 |
Small dose of clonidine mixed with low-dose ropivacaine and fentanyl for epidural analgesia after total knee arthroplasty.
Topics: Adult; Aged; Aged, 80 and over; Amides; Analgesia, Epidural; Analgesics; Analgesics, Opioid; Anesthe | 2004 |
Caudal analgesia in children: S(+)-ketamine vs S(+)-ketamine plus clonidine.
Topics: Adrenergic alpha-Agonists; Analgesia; Anesthesia Recovery Period; Anesthesia, Caudal; Anesthetics, D | 2004 |
Small-dose intrathecal clonidine and isobaric bupivacaine for orthopedic surgery: a dose-response study.
Topics: Adjuvants, Anesthesia; Adrenergic alpha-Agonists; Aged; Analgesics, Opioid; Anesthesia, Spinal; Anes | 2004 |
Clonidine vs. midazolam as premedication in children undergoing adeno-tonsillectomy: a prospective, randomized, controlled clinical trial.
Topics: Adenoidectomy; Adrenergic alpha-Agonists; Anesthesia; Behavior; Child; Child, Preschool; Clonidine; | 2004 |
Combinations of bupivacaine, fentanyl, and clonidine for lumbar epidural postoperative analgesia: a novel optimization procedure.
Topics: Adolescent; Adrenergic alpha-Agonists; Adult; Aged; Aged, 80 and over; Analgesia, Epidural; Analgesi | 2004 |
Intraoperative clonidine administration to neurosurgical patients.
Topics: Adrenergic alpha-Agonists; Adult; Aged; Anesthesia Recovery Period; Clonidine; Double-Blind Method; | 2005 |
The clinical effect of small oral clonidine doses on perioperative outcomes in patients undergoing abdominal hysterectomy.
Topics: Administration, Oral; Adolescent; Adult; Aged; Analgesics; Anti-Anxiety Agents; Anxiety; Blood Press | 2005 |
Adding clonidine to the induction bolus and postoperative infusion during continuous femoral nerve block delays recovery of motor function after total knee arthroplasty.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anesthesia Recovery Period; Anesthetics, Local; Arthropl | 2005 |
Intravenous but not perineural clonidine prolongs postoperative analgesia after psoas compartment block with 0.5% levobupivacaine for hip fracture surgery.
Topics: Aged; Aged, 80 and over; Bupivacaine; Clonidine; Double-Blind Method; Female; Hip Fractures; Humans; | 2005 |
Fast-track coronary artery bypass grafting surgery under general anesthesia with remifentanil and spinal analgesia with morphine and clonidine.
Topics: Aged; Anesthesia, General; Anesthesia, Spinal; Clonidine; Coronary Artery Bypass; Drug Therapy, Comb | 2005 |
Improved analgesia with clonidine when added to local anesthetic during combined spinal-epidural anesthesia for hip arthroplasty: a double-blind, randomized and placebo-controlled study.
Topics: Adjuvants, Anesthesia; Adrenergic alpha-Agonists; Adult; Aged; Analgesics, Opioid; Anesthesia, Epidu | 2005 |
Clonidine added to a continuous interscalene ropivacaine perineural infusion to improve postoperative analgesia: a randomized, double-blind, controlled study.
Topics: Adrenergic alpha-Agonists; Amides; Anesthetics, Local; Clonidine; Double-Blind Method; Drug Therapy, | 2005 |
The combination of epidural clonidine and S(+)-ketamine did not enhance analgesic efficacy beyond that for each individual drug in adult orthopedic surgery.
Topics: Adult; Aged; Analgesia, Epidural; Analgesics; Clonidine; Double-Blind Method; Drug Synergism; Female | 2005 |
The addition of clonidine 2 microg.kg-1 does not enhance the postoperative analgesia of a caudal block using 0.125% bupivacaine and epinephrine 1:200,000 in children: a prospective, double-blind, randomized study.
Topics: Adjuvants, Anesthesia; Adrenergic alpha-Agonists; Anesthesia, Caudal; Anesthesia, General; Anestheti | 2005 |
Intraarticular analgesia after arthroscopic knee surgery: comparison of neostigmine, clonidine, tenoxicam, morphine and bupivacaine.
Topics: Analgesics, Opioid; Arthroplasty, Replacement, Knee; Bupivacaine; Cholinesterase Inhibitors; Clonidi | 2005 |
Clonidine administered as adjuvant for bupivacaine in ilioinguinal-iliohypogastric nerve block does not prolong postoperative analgesia.
Topics: Adjuvants, Anesthesia; Adrenergic alpha-Agonists; Ambulatory Surgical Procedures; Analgesia; Anesthe | 2005 |
The short-lasting analgesia and long-term antihyperalgesic effect of intrathecal clonidine in patients undergoing colonic surgery.
Topics: Adrenergic alpha-Agonists; Aged; Analgesia; Analgesia, Patient-Controlled; Analgesics, Opioid; Anest | 2005 |
Comparison of clonidine and epinephrine in lidocaine anaesthesia for lower third molar surgery.
Topics: Adolescent; Adrenergic alpha-Agonists; Adult; Aged; Anesthesia, Dental; Anesthetics, Local; Blood Pr | 2005 |
[Postoperative analgesia with intraarticular local anesthetic bupivacaine and alpha2-agonist clonidine after arthroscopic knee surgery].
Topics: Adult; Aged; Analgesics; Anesthetics, Local; Arthroscopy; Bupivacaine; Clonidine; Double-Blind Metho | 2005 |
Clonidine increases duration of bupivacaine caudal analgesia for ureteroneocystostomy: a double-blind prospective trial.
Topics: Analgesics; Anesthesia Recovery Period; Anesthesia, Caudal; Anesthesia, General; Anesthetics, Local; | 2005 |
Clonidine increases duration of bupivacaine caudal analgesia for ureteroneocystostomy: a double-blind prospective trial.
Topics: Analgesics; Anesthesia Recovery Period; Anesthesia, Caudal; Anesthesia, General; Anesthetics, Local; | 2005 |
Clonidine increases duration of bupivacaine caudal analgesia for ureteroneocystostomy: a double-blind prospective trial.
Topics: Analgesics; Anesthesia Recovery Period; Anesthesia, Caudal; Anesthesia, General; Anesthetics, Local; | 2005 |
Clonidine increases duration of bupivacaine caudal analgesia for ureteroneocystostomy: a double-blind prospective trial.
Topics: Analgesics; Anesthesia Recovery Period; Anesthesia, Caudal; Anesthesia, General; Anesthetics, Local; | 2005 |
Clonidine increases duration of bupivacaine caudal analgesia for ureteroneocystostomy: a double-blind prospective trial.
Topics: Analgesics; Anesthesia Recovery Period; Anesthesia, Caudal; Anesthesia, General; Anesthetics, Local; | 2005 |
Clonidine increases duration of bupivacaine caudal analgesia for ureteroneocystostomy: a double-blind prospective trial.
Topics: Analgesics; Anesthesia Recovery Period; Anesthesia, Caudal; Anesthesia, General; Anesthetics, Local; | 2005 |
Clonidine increases duration of bupivacaine caudal analgesia for ureteroneocystostomy: a double-blind prospective trial.
Topics: Analgesics; Anesthesia Recovery Period; Anesthesia, Caudal; Anesthesia, General; Anesthetics, Local; | 2005 |
Clonidine increases duration of bupivacaine caudal analgesia for ureteroneocystostomy: a double-blind prospective trial.
Topics: Analgesics; Anesthesia Recovery Period; Anesthesia, Caudal; Anesthesia, General; Anesthetics, Local; | 2005 |
Clonidine increases duration of bupivacaine caudal analgesia for ureteroneocystostomy: a double-blind prospective trial.
Topics: Analgesics; Anesthesia Recovery Period; Anesthesia, Caudal; Anesthesia, General; Anesthetics, Local; | 2005 |
[Effectiveness of clonidine and fentanyl addition to bupivacaine in postoperative patient controlled epidural analgesia].
Topics: Adolescent; Adrenergic alpha-Agonists; Adult; Aged; Analgesia, Epidural; Analgesia, Patient-Controll | 2005 |
Comparison of three different epidural solutions in off-pump cardiac surgery: pilot study.
Topics: Adult; Aged; Aged, 80 and over; Analgesia, Epidural; Anesthetics, Local; Blood Pressure; Bupivacaine | 2005 |
Intraarticular bupivacaine-clonidine-morphine versus femoral-sciatic nerve block in pediatric patients undergoing anterior cruciate ligament reconstruction.
Topics: Adolescent; Adult; Anterior Cruciate Ligament; Bupivacaine; Child; Clonidine; Female; Femoral Nerve; | 2005 |
Inguinal herniorrhaphy under monitored anesthesia care with ilioinguinal-iliohypogastric block: the impact of adding clonidine to ropivacaine.
Topics: Adrenergic alpha-Agonists; Adult; Aged; Amides; Anesthetics, Local; Clonidine; Double-Blind Method; | 2005 |
Pain relief and functional status after vaginal hysterectomy: intrathecal versus general anesthesia.
Topics: Analgesics; Analgesics, Opioid; Anesthesia, General; Anesthetics, Local; Bupivacaine; Clonidine; Com | 2006 |
The effect of addition of intrathecal clonidine to hyperbaric bupivacaine on postoperative pain and morphine requirements after Caesarean section: a randomized controlled trial.
Topics: Adult; Analgesics, Opioid; Anesthesia, Obstetrical; Anesthesia, Spinal; Bupivacaine; Cesarean Sectio | 2006 |
A comparison of epidural bupivacaine-fentanyl and bupivacaine-clonidine in children undergoing the Nuss procedure.
Topics: Adolescent; Adult; Analgesia, Epidural; Bupivacaine; Child; Clonidine; Double-Blind Method; Female; | 2006 |
Fentanyl and clonidine as adjunctive analgesics with levobupivacaine in paravertebral analgesia for breast surgery.
Topics: Adult; Aged; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Breast Neoplasms; Bupiva | 2006 |
Effectiveness of local anaesthesia (clonidine and fentanyl) infiltration for post-submucosal resection pain relief: a randomized, double-blinded clinical trial.
Topics: Adult; Analgesics; Anesthesia, Local; Anesthetics, Combined; Anesthetics, Intravenous; Clonidine; Do | 2007 |
Clonidine as an analgesic adjuvant to continuous paravertebral bupivacaine for post-thoracotomy pain.
Topics: Adrenergic alpha-Agonists; Adult; Aged; Anesthetics, Local; Blood Pressure; Bupivacaine; Clonidine; | 2006 |
Does clonidine 50 microg improve cervical plexus block obtained with ropivacaine 150 mg for carotid endarterectomy? A randomized, double-blinded study.
Topics: Aged; Aged, 80 and over; Amides; Analgesics; Anesthetics, Local; Cervical Plexus; Clonidine; Double- | 2006 |
[Addition of sodium bicarbonate and/or clonidine to mepivacaine: influence on axillary brachial plexus block characteristics].
Topics: Adjuvants, Anesthesia; Adolescent; Adrenergic alpha-Agonists; Adult; Aged; Anesthesia Recovery Perio | 2006 |
[Femoral nerve block for postoperative analgesia after anterior cruciate ligament reconstruction: comparison of 2 concentrations of bupivacaine with clonidine in 3 modes of administration].
Topics: Adolescent; Adult; Analgesia, Patient-Controlled; Analgesics; Analgesics, Non-Narcotic; Anesthetics, | 2006 |
Bilateral ilioinguinal nerve block decreases morphine consumption in female patients undergoing nonlaparoscopic gynecologic surgery.
Topics: Adult; Amides; Analgesia, Patient-Controlled; Analgesics, Opioid; Anesthesia, Local; Clonidine; Doub | 2007 |
Epidural clonidine for postoperative pain after total knee arthroplasty: a dose-response study.
Topics: Adult; Aged; Aged, 80 and over; Analgesia, Epidural; Arthroplasty, Replacement, Knee; Clonidine; Dos | 2007 |
A comparison of single-dose caudal clonidine, morphine, or hydromorphone combined with ropivacaine in pediatric patients undergoing ureteral reimplantation.
Topics: Amides; Analgesia, Epidural; Child; Child, Preschool; Clonidine; Double-Blind Method; Drug Therapy, | 2007 |
A comparison of single-dose caudal clonidine, morphine, or hydromorphone combined with ropivacaine in pediatric patients undergoing ureteral reimplantation.
Topics: Amides; Analgesia, Epidural; Child; Child, Preschool; Clonidine; Double-Blind Method; Drug Therapy, | 2007 |
A comparison of single-dose caudal clonidine, morphine, or hydromorphone combined with ropivacaine in pediatric patients undergoing ureteral reimplantation.
Topics: Amides; Analgesia, Epidural; Child; Child, Preschool; Clonidine; Double-Blind Method; Drug Therapy, | 2007 |
A comparison of single-dose caudal clonidine, morphine, or hydromorphone combined with ropivacaine in pediatric patients undergoing ureteral reimplantation.
Topics: Amides; Analgesia, Epidural; Child; Child, Preschool; Clonidine; Double-Blind Method; Drug Therapy, | 2007 |
Effects of preanesthetic administration of midazolam, clonidine, or dexmedetomidine on postoperative pain and anxiety in children.
Topics: Adrenergic alpha-Agonists; Anesthetics, Intravenous; Anxiety; Blood Pressure; Carbon Dioxide; Child, | 2007 |
Evaluation of a muscle relaxant on sequelae of third molar surgery: a pilot study.
Topics: Adolescent; Adult; Clonidine; Edema; Epidemiologic Methods; Female; Humans; Male; Middle Aged; Molar | 2007 |
Clonidine 1 microg/kg is a safe and effective adjuvant to plain bupivacaine in spinal anesthesia in adolescents.
Topics: Adjuvants, Pharmaceutic; Adolescent; Anesthesia, Spinal; Bupivacaine; Child; Clonidine; Double-Blind | 2007 |
Analgesic efficacy of bilateral superficial cervical plexus block administered before thyroid surgery under general anaesthesia.
Topics: Adult; Aged; Amides; Analgesics, Non-Narcotic; Analgesics, Opioid; Anesthesia, General; Anesthetics, | 2007 |
Analgesic efficacy of bilateral superficial cervical plexus block administered before thyroid surgery under general anaesthesia.
Topics: Adult; Aged; Amides; Analgesics, Non-Narcotic; Analgesics, Opioid; Anesthesia, General; Anesthetics, | 2007 |
Analgesic efficacy of bilateral superficial cervical plexus block administered before thyroid surgery under general anaesthesia.
Topics: Adult; Aged; Amides; Analgesics, Non-Narcotic; Analgesics, Opioid; Anesthesia, General; Anesthetics, | 2007 |
Analgesic efficacy of bilateral superficial cervical plexus block administered before thyroid surgery under general anaesthesia.
Topics: Adult; Aged; Amides; Analgesics, Non-Narcotic; Analgesics, Opioid; Anesthesia, General; Anesthetics, | 2007 |
Lidocaine+clonidine for maxillary infiltration anaesthesia: parameters of anaesthesia and vascular effects.
Topics: Adrenergic alpha-Agonists; Adult; Analgesics; Anesthesia, Local; Anesthetics, Local; Arteries; Blood | 2008 |
Pre-incisional epidural ropivacaine, sufentanil, clonidine, and (S)+-ketamine does not provide pre-emptive analgesia in patients undergoing major pancreatic surgery.
Topics: Adult; Aged; Amides; Analgesia, Epidural; Analgesia, Patient-Controlled; Clonidine; Double-Blind Met | 2008 |
A modified fascia iliaca compartment block has significant morphine-sparing effect after total hip arthroplasty.
Topics: Aged; Analgesia, Patient-Controlled; Analgesics, Opioid; Anesthetics, Local; Arthroplasty, Replaceme | 2007 |
Effects of clonidine preemptive analgesia on acute postoperative pain in abdominal surgery.
Topics: Abdomen; Acute Disease; Adrenergic alpha-Agonists; Adult; Aged; Clonidine; Humans; Middle Aged; Pain | 2007 |
Analysis of preincisional and postincisional treatment with alpha2-adrenoreceptor agonist clonidine regarding analgesic consumption and hemodynamic stability in surgical patients.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-Agonists; Analgesia, Epidural; Analgesia, Pat | 2007 |
Comparative study of epidural xylazine or clonidine in horses.
Topics: Adrenergic alpha-Agonists; Anesthesia, Epidural; Animals; Behavior, Animal; Clonidine; Double-Blind | 2008 |
Epidural vs. lumbar plexus infusions following total knee arthroplasty: randomized controlled trial.
Topics: Aged; Analgesia, Epidural; Analgesics; Anesthetics, Local; Arthroplasty, Replacement, Knee; Bupivaca | 2008 |
Clonidine and analgesic duration after popliteal fossa nerve blockade: randomized, double-blind, placebo-controlled study.
Topics: Adult; Aged; Analgesia, Patient-Controlled; Analgesics; Anesthetics, Local; Bupivacaine; Clonidine; | 2008 |
Epidural clonidine or sufentanil for intraoperative and postoperative analgesia.
Topics: Abdomen; Adolescent; Adult; Analgesia, Epidural; Analgesia, Patient-Controlled; Analgesics, Opioid; | 1995 |
Comparison of intravenous and epidural clonidine for postoperative patient-controlled analgesia.
Topics: Adult; Analgesia, Epidural; Analgesia, Patient-Controlled; Analgesics; Clonidine; Double-Blind Metho | 1995 |
An isobolographic study of epidural clonidine and fentanyl after cesarean section.
Topics: Adult; Analgesia, Epidural; Cesarean Section; Clonidine; Dose-Response Relationship, Drug; Double-Bl | 1994 |
Analgesic and hemodynamic effects of epidural clonidine, clonidine/morphine, and morphine after pancreatic surgery--a double-blind study.
Topics: Analgesia, Epidural; Clonidine; Double-Blind Method; Female; Hemodynamics; Humans; Male; Middle Aged | 1995 |
Thoracic epidural clonidine and morphine for postoperative pain relief.
Topics: Analgesia, Epidural; Analgesia, Patient-Controlled; Anesthesia, Epidural; Anesthesia, Inhalation; Bl | 1995 |
The effect of clonidine on intra-operative requirements of fentanyl during combined epidural/general anaesthesia.
Topics: Adult; Analgesia, Epidural; Anesthesia Recovery Period; Anesthesia, Epidural; Anesthesia, General; C | 1994 |
Postoperative analgesia after co-administration of clonidine and morphine by the intrathecal route in patients undergoing hip replacement.
Topics: Aged; Clonidine; Drug Combinations; Female; Hip Prosthesis; Humans; Injections, Spinal; Male; Morphi | 1995 |
Co-administration of pethidine and clonidine: a spinal anaesthetic technique for total hip replacement.
Topics: Adult; Aged; Aged, 80 and over; Anesthesia, Spinal; Blood Pressure; Bupivacaine; Clonidine; Female; | 1994 |
Effects of intrathecal clonidine on duration of bupivacaine spinal anaesthesia, haemodynamics, and postoperative analgesia in patients undergoing knee arthroscopy.
Topics: Adolescent; Adult; Anesthesia, Spinal; Arthroscopy; Blood Pressure; Bupivacaine; Clonidine; Double-B | 1994 |
Sympathetic suppression attenuates anomalous responses to morphine in unexplained pain after cholecystectomy.
Topics: Adult; Cholecystectomy; Clonidine; Cross-Over Studies; Female; Humans; Male; Middle Aged; Morphine; | 1994 |
Patient-controlled epidural analgesia with sufentanil following caesarean section: the effect of adrenaline and clonidine admixture.
Topics: Adult; Analgesia, Epidural; Analgesia, Obstetrical; Analgesia, Patient-Controlled; Cesarean Section; | 1994 |
Balanced postoperative analgesia: effect of intravenous clonidine on blood gases and pharmacokinetics of intravenous fentanyl.
Topics: Adult; Analgesia; Blood Pressure; Carbon Dioxide; Clonidine; Dose-Response Relationship, Drug; Doubl | 1994 |
Prevention of phantom pain after major lower limb amputation by epidural infusion of diamorphine, clonidine and bupivacaine.
Topics: Adult; Aged; Aged, 80 and over; Amputation, Surgical; Analgesics; Bupivacaine; Clonidine; Drug Combi | 1994 |
Comparison of a bupivacaine-clonidine mixture with plain bupivacaine for caudal analgesia in children.
Topics: Acetaminophen; Analgesia, Epidural; Bupivacaine; Cauda Equina; Child; Child, Preschool; Clonidine; D | 1994 |
Clonidine in pediatric caudal anesthesia.
Topics: Anesthesia, Caudal; Bupivacaine; Child; Child, Preschool; Clonidine; Double-Blind Method; Epinephrin | 1994 |
Intraoperative and postoperative analgesia using intravenous opioid, clonidine and lignocaine.
Topics: Adult; Aged; Analgesia; Analgesia, Patient-Controlled; Clonidine; Colectomy; Double-Blind Method; Fe | 1994 |
Addition of oral clonidine to postoperative patient-controlled analgesia with i.v. morphine.
Topics: Administration, Oral; Adult; Aged; Analgesia, Patient-Controlled; Clonidine; Double-Blind Method; Dr | 1994 |
Comparison of the analgesic effects of intrathecal clonidine and intrathecal morphine after spinal anaesthesia in patients undergoing total hip replacement.
Topics: Adult; Aged; Aged, 80 and over; Anesthesia, Spinal; Bupivacaine; Clonidine; Female; Hip Prosthesis; | 1993 |
Comparisons of tetracaine spinal anesthesia with clonidine or phenylephrine in normotensive and hypertensive humans.
Topics: Adult; Aged; Anesthesia, Spinal; Blood Pressure; Clonidine; Female; Hemodynamics; Humans; Hypertensi | 1994 |
Partial reversal of the effects of extradural clonidine by oral yohimbine in postoperative patients.
Topics: Administration, Oral; Adolescent; Adult; Aged; Analgesia, Epidural; Blood Pressure; Clonidine; Femal | 1993 |
Intravenous or epidural clonidine for intra- and postoperative analgesia.
Topics: Adolescent; Adult; Analgesia, Epidural; Anesthesia, Intravenous; Clonidine; Double-Blind Method; Fem | 1993 |
Oral clonidine premedication reduces postoperative pain in children.
Topics: Administration, Oral; Adrenergic alpha-Agonists; Analgesics; Anesthesia; Child; Child, Preschool; Cl | 1996 |
Oral clonidine premedication reduces vomiting in children after strabismus surgery.
Topics: Administration, Oral; Adrenergic alpha-Agonists; Anesthesia, Inhalation; Anti-Inflammatory Agents, N | 1995 |
Comparison of the effects of adrenaline, clonidine and ketamine on the duration of caudal analgesia produced by bupivacaine in children.
Topics: Analgesia; Anesthetics, Dissociative; Anesthetics, Local; Bupivacaine; Child; Child, Preschool; Clon | 1995 |
[Patient-controlled analgesia with clonidine and piritramide].
Topics: Adolescent; Adult; Aged; Analgesia, Patient-Controlled; Analgesics, Opioid; Clonidine; Dose-Response | 1996 |
Peripheral analgesic effect of intra-articular clonidine.
Topics: Adrenergic Agents; Adult; Analgesics, Non-Narcotic; Arthroscopy; Clonidine; Double-Blind Method; Fem | 1996 |
Postoperative analgesia after peripheral nerve block for podiatric surgery: clinical efficacy and chemical stability of lidocaine alone versus lidocaine plus clonidine.
Topics: Adrenergic alpha-Agonists; Adult; Analgesia; Analgesics; Analysis of Variance; Anesthetics, Local; A | 1996 |
Clonidine-mepivacaine mixture vs plain mepivacaine in paediatric surgery.
Topics: Adjuvants, Anesthesia; Adrenergic alpha-Agonists; Anesthesia, Caudal; Anesthetics, Local; Child; Chi | 1996 |
Oral clonidine reduces postoperative PCA morphine requirements.
Topics: Administration, Oral; Adrenergic alpha-Agonists; Aged; Analgesia, Patient-Controlled; Clonidine; Dou | 1996 |
A minimum dose of clonidine added to mepivacaine prolongs the duration of anesthesia and analgesia after axillary brachial plexus block.
Topics: Adrenergic alpha-Agonists; Adult; Ambulatory Surgical Procedures; Analgesia; Analgesics; Anesthetics | 1996 |
Comparative assessment of the anaesthetic and analgesic effects of intramuscular and epidural clonidine in humans.
Topics: Adult; Analgesia, Epidural; Analgesics, Non-Narcotic; Anesthetics; Clonidine; Double-Blind Method; F | 1996 |
Potentiation of sufentanil by clonidine in PCEA with or without basal infusion.
Topics: Adrenergic alpha-Agonists; Adult; Analgesia, Patient-Controlled; Analgesics, Opioid; Cesarean Sectio | 1996 |
The addition of clonidine to prilocaine for intravenous regional anaesthesia.
Topics: Adrenergic alpha-Agonists; Adult; Anesthesia, Conduction; Anesthesia, Intravenous; Anesthetics, Comb | 1997 |
Postoperative analgesia using a low-dose, oral-transdermal clonidine combination: lack of clinical efficacy.
Topics: Administration, Cutaneous; Administration, Oral; Adrenergic alpha-Agonists; Analgesia, Patient-Contr | 1997 |
Epidural clonidine used as the sole analgesic agent during and after abdominal surgery. A dose-response study.
Topics: Adult; Analgesia, Epidural; Analgesics, Non-Narcotic; Clonidine; Dose-Response Relationship, Drug; D | 1997 |
[Continuous intra- and postoperative peridural analgesia with combined low dose sufentanil, clonidine and bupivacaine].
Topics: Abdomen; Adult; Aged; Analgesia, Epidural; Bupivacaine; Clonidine; Dose-Response Relationship, Drug; | 1996 |
Postoperative epidural infusion: a randomized, double-blind, dose-finding trial of clonidine in combination with bupivacaine and fentanyl.
Topics: Adrenergic alpha-Agonists; Adult; Analgesia, Epidural; Analgesia, Patient-Controlled; Anesthetics, I | 1997 |
Spinal anesthesia with meperidine. Effects of added alpha-adrenergic agonists: epinephrine versus clonidine.
Topics: Adjuvants, Anesthesia; Adolescent; Adrenergic alpha-Agonists; Adult; Aged; Anesthesia, Spinal; Blood | 1997 |
Intravenous regional anesthesia. Evaluation of 4 different additives to prilocaine.
Topics: Adjuvants, Anesthesia; Adolescent; Adrenergic alpha-Agonists; Adult; Aged; Analgesics, Opioid; Anest | 1997 |
Caudal clonidine and bupivacaine for combined epidural and general anaesthesia in children.
Topics: Adrenergic alpha-Agonists; Anesthesia, Caudal; Anesthesia, General; Anesthetics, Local; Bupivacaine; | 1997 |
Comparison of epidural butorphanol plus clonidine with butorphanol alone for postoperative pain relief.
Topics: Adrenergic alpha-Agonists; Adult; Analgesics, Opioid; Butorphanol; Clonidine; Double-Blind Method; D | 1997 |
Epidural bolus clonidine/morphine versus epidural patient-controlled bupivacaine/sufentanil: quality of postoperative analgesia and cost-identification analysis.
Topics: Adult; Aged; Analgesia, Epidural; Analgesia, Patient-Controlled; Analgesics; Bupivacaine; Clonidine; | 1997 |
Does the addition of clonidine affect duration of analgesia of bupivacaine wound infiltration in inguinal hernia surgery?
Topics: Adrenergic alpha-Agonists; Aged; Analgesia; Anesthetics, Local; Bupivacaine; Clonidine; Double-Blind | 1997 |
Intra-articular morphine and clonidine produce comparable analgesia but the combination is not more effective.
Topics: Adolescent; Adult; Aged; Analgesics, Opioid; Arthroscopy; Clonidine; Double-Blind Method; Drug Combi | 1997 |
Transcutaneous CO2 tension effects of clonidine in paediatric caudal analgesia.
Topics: Adrenergic alpha-Agonists; Analgesia, Epidural; Anesthesia, Inhalation; Anesthetics, Local; Blood Ga | 1998 |
Addition of clonidine or fentanyl to local anaesthetics prolongs the duration of surgical analgesia after single shot caudal block in children.
Topics: Adrenergic alpha-Agonists; Analgesia; Analgesics, Non-Narcotic; Analgesics, Opioid; Anesthesia, Caud | 1998 |
Clonidine added to the anesthetic solution enhances analgesia and improves oxygenation after intercostal nerve block for thoracotomy.
Topics: Adrenergic alpha-Agonists; Aged; Analgesia; Anesthesia; Anesthetics, Local; Blood Pressure; Bupivaca | 1998 |
[The effects of a dose of epidural clonidine combined with intrathecal morphine for postoperative analgesia].
Topics: Adrenergic alpha-Agonists; Adult; Analgesia, Epidural; Analgesics, Opioid; Cesarean Section; Clonidi | 1998 |
Clinical study of epidural analgesia with clonidine and sumatriptan in posthysterectomy.
Topics: Adult; Analgesia, Epidural; Analgesics, Non-Narcotic; Animals; Clonidine; Drug Therapy, Combination; | 1997 |
The effectiveness of clonidine as an analgesic in paediatric adenotonsillectomy.
Topics: Acetaminophen; Adenoidectomy; Administration, Oral; Analgesics; Analgesics, Non-Narcotic; Analgesics | 1998 |
Comparison of clonidine 1 microgram kg-1 with morphine 30 micrograms kg-1 for post-operative caudal analgesia in children.
Topics: Abdomen; Analgesia, Epidural; Analgesics; Analgesics, Opioid; Anesthesia Recovery Period; Anesthesia | 1999 |
Postoperative analgesia for outpatient arthroscopic knee surgery with intraarticular clonidine.
Topics: Adult; Ambulatory Surgical Procedures; Analgesia; Analgesics; Arthroscopy; Bupivacaine; Clonidine; D | 1999 |
Epidural clonidine or bupivacaine as the sole analgesic agent during and after abdominal surgery: a comparative study.
Topics: Abdomen; Adolescent; Adrenergic alpha-Agonists; Adult; Analgesics, Non-Narcotic; Bupivacaine; Clonid | 1999 |
Clonidine administered as an axillary block does not affect postoperative pain when given as the sole analgesic.
Topics: Adult; Analgesics, Non-Narcotic; Brachial Plexus; Clonidine; Double-Blind Method; Female; Humans; Ma | 1999 |
Intravenous regional anesthesia using lidocaine and clonidine.
Topics: Adrenergic alpha-Agonists; Adult; Aged; Anesthetics, Local; Clonidine; Double-Blind Method; Hand; Hu | 1999 |
Oral clonidine premedication enhances postoperative analgesia by epidural morphine.
Topics: Administration, Oral; Adolescent; Adrenergic alpha-Agonists; Adult; Analgesia, Epidural; Analgesics; | 1999 |
A direct search procedure to optimize combinations of epidural bupivacaine, fentanyl, and clonidine for postoperative analgesia.
Topics: Adrenergic alpha-Agonists; Adult; Aged; Aged, 80 and over; Analgesia, Epidural; Analgesics, Opioid; | 2000 |
Ropivacaine-clonidine combination for caudal blockade in children.
Topics: Adjuvants, Anesthesia; Adrenergic alpha-Agonists; Amides; Anesthesia, Caudal; Anesthetics, Local; Ch | 2000 |
Influence of intravenous clonidine pretreatment on anesthetic requirements during bispectral EEG-guided sevoflurane anesthesia.
Topics: Adolescent; Adult; Aged; Anesthesia, Inhalation; Anesthetics, Inhalation; Anesthetics, Local; Bupiva | 2000 |
Postoperative analgesia for outpatient arthroscopic knee surgery with intraarticular clonidine and/or morphine.
Topics: Adult; Ambulatory Surgical Procedures; Analgesics; Analgesics, Opioid; Anesthesia, Local; Anesthetic | 2000 |
Caudal clonidine for postoperative analgesia in adults.
Topics: Adult; Aged; Aged, 80 and over; Analgesics; Analysis of Variance; Anesthesia, Caudal; Anesthetics, L | 2000 |
Extended "three-in-one" block after total knee arthroplasty: continuous versus patient-controlled techniques.
Topics: Aged; Analgesia, Patient-Controlled; Analgesics; Anesthetics, Local; Arthroplasty, Replacement, Knee | 2000 |
Small-dose clonidine prolongs postoperative analgesia after sciatic-femoral nerve block with 0.75% ropivacaine for foot surgery.
Topics: Adult; Aged; Amides; Analgesics; Anesthetics, Local; Clonidine; Double-Blind Method; Female; Femoral | 2000 |
Intra-articular clonidine analgesia after knee arthroscopy.
Topics: Adrenergic alpha-Agonists; Adult; Aged; Analgesics, Non-Narcotic; Analgesics, Opioid; Anesthesia, Ge | 2000 |
The influence of sufentanil and/or clonidine on the duration of analgesia after a caudal block for hypospadias repair surgery in children.
Topics: Adolescent; Adrenergic alpha-Agonists; Analgesics, Opioid; Anesthesia, Caudal; Anesthetics, Local; B | 2000 |
[Premedication in maxillofacial surgery under total intravenous anesthesia . Effects of clonidine compared to midazolam on the perioperative course].
Topics: Adjuvants, Anesthesia; Adrenergic alpha-Agonists; Adult; Anesthesia, Intravenous; Clonidine; Double- | 2000 |
Premedication with low dose oral clonidine does not enhance postoperative analgesia of intrathecal morphine.
Topics: Administration, Oral; Aged; Analgesics; Clonidine; Double-Blind Method; Drug Synergism; Humans; Inje | 2000 |
Effect of oral clonidine premedication on perioperative hemodynamic response and postoperative analgesic requirement for patients undergoing laparoscopic cholecystectomy.
Topics: Administration, Oral; Adult; Aged; Cholecystectomy, Laparoscopic; Clonidine; Female; Hemodynamics; H | 2000 |
Low-dose intrathecal clonidine combined with sufentanil as analgesic drugs in abdominal gynecological surgery.
Topics: Abdomen; Adrenergic alpha-Agonists; Adult; Analgesics; Analgesics, Opioid; Blood Pressure; Clonidine | 2000 |
Diclofenac and flurbiprofen with or without clonidine for postoperative analgesia in children undergoing elective ophthalmological surgery.
Topics: Administration, Oral; Administration, Rectal; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; C | 2000 |
A comparison of oral clonidine and oral midazolam as preanesthetic medications in the pediatric tonsillectomy patient.
Topics: Adenoidectomy; Administration, Oral; Adrenergic alpha-Agonists; Anti-Anxiety Agents; Blood Pressure; | 2001 |
Clonidine decreases intraoperative bleeding in middle ear microsurgery.
Topics: Adrenergic alpha-Agonists; Adult; Analgesics; Blood Loss, Surgical; Clonidine; Double-Blind Method; | 2001 |
[Addition of clonidine to 0.5% lidocaine for intravenous locoregional anesthesia].
Topics: Adult; Analysis of Variance; Anesthesia, Intravenous; Anesthesia, Local; Anesthetics, Local; Anti-In | 2001 |
Improving postoperative analgesia after axillary brachial plexus anesthesia with 0.75% ropivacaine. A double-blind evaluation of adding clonidine.
Topics: Adrenergic alpha-Agonists; Adult; Aged; Amides; Anesthesia, Intravenous; Anesthetics, Local; Brachia | 2001 |
The dose-response relationship for clonidine added to a postoperative continuous epidural infusion of ropivacaine in children.
Topics: Adrenergic alpha-Agonists; Amides; Analgesia, Epidural; Anesthesia; Anesthetics, Local; Child, Presc | 2001 |
Ropivacaine with or without clonidine improves pediatric tonsillectomy pain.
Topics: Adolescent; Amides; Analgesics; Anesthetics, Local; Child; Child, Preschool; Clonidine; Female; Huma | 2001 |
How to prolong postoperative analgesia after caudal anaesthesia with ropivacaine in children: S-ketamine versus clonidine.
Topics: Adrenergic alpha-Agonists; Amides; Analgesia, Epidural; Anesthesia Recovery Period; Anesthetics, Dis | 2001 |
Analgesia for circumcision in a paediatric population: comparison of caudal bupivacaine alone with bupivacaine plus two doses of clonidine.
Topics: Adrenergic alpha-Agonists; Analgesia; Anesthesia, Spinal; Anesthetics, Local; Bupivacaine; Child; Ch | 2001 |
Analgesia for circumcision in a paediatric population: comparison of caudal bupivacaine alone with bupivacaine plus two doses of clonidine.
Topics: Adrenergic alpha-Agonists; Analgesia; Anesthesia, Spinal; Anesthetics, Local; Bupivacaine; Child; Ch | 2001 |
Analgesia for circumcision in a paediatric population: comparison of caudal bupivacaine alone with bupivacaine plus two doses of clonidine.
Topics: Adrenergic alpha-Agonists; Analgesia; Anesthesia, Spinal; Anesthetics, Local; Bupivacaine; Child; Ch | 2001 |
Analgesia for circumcision in a paediatric population: comparison of caudal bupivacaine alone with bupivacaine plus two doses of clonidine.
Topics: Adrenergic alpha-Agonists; Analgesia; Anesthesia, Spinal; Anesthetics, Local; Bupivacaine; Child; Ch | 2001 |
Dolasetron for preventing postanesthetic shivering.
Topics: Abdomen; Analgesics; Anesthesia; Body Temperature; Clonidine; Double-Blind Method; Female; Humans; I | 2002 |
Epidural administration of low-dose morphine combined with clonidine for postoperative analgesia after lumbar disc surgery.
Topics: Adjuvants, Anesthesia; Adult; Analgesia, Epidural; Analgesia, Patient-Controlled; Analgesics; Analge | 2002 |
Clonidine for treatment of postoperative pain: a dose-finding study.
Topics: Adult; Analgesics; Anesthetics, General; Blood Pressure; Clonidine; Dose-Response Relationship, Drug | 2002 |
Clonidine as coadjuvant in eye surgery: comparison of peribulbar versus oral administration.
Topics: Adjuvants, Anesthesia; Administration, Oral; Aged; Blood Pressure; Clonidine; Double-Blind Method; F | 2002 |
Does dexamethasone with preemptive analgesia improve pediatric tonsillectomy pain?
Topics: Adolescent; Amides; Analysis of Variance; Anti-Inflammatory Agents, Non-Steroidal; Child; Child, Pre | 2002 |
Effects of clonidine on postoperative nausea and vomiting in breast cancer surgery.
Topics: Adrenergic alpha-Agonists; Aged; Anesthesia, General; Antiemetics; Blood Pressure; Breast Neoplasms; | 2002 |
Enhancement of pentazocine analgesia by clonidine.
Topics: Adrenergic alpha-Agonists; Analgesia; Analysis of Variance; Clonidine; Double-Blind Method; Drug Int | 1992 |
Ventilatory effects of epidural clonidine during the first 3 hours after caesarean section.
Topics: Analgesia, Epidural; Analgesia, Obstetrical; Apnea; Cesarean Section; Clonidine; Double-Blind Method | 1992 |
Epidural clonidine enhances postoperative analgesia from a combined low-dose epidural bupivacaine and morphine regimen.
Topics: Adult; Analgesia, Epidural; Bupivacaine; Clonidine; Double-Blind Method; Female; Humans; Hysterectom | 1992 |
Extradural clonidine and bupivacaine for postoperative analgesia.
Topics: Adult; Aged; Analgesia, Epidural; Bupivacaine; Clonidine; Female; Hemodynamics; Hip Prosthesis; Huma | 1992 |
Comparison between clonidine and epinephrine admixture to lidocaine in brachial plexus block.
Topics: Adult; Anesthesia, Local; Brachial Plexus; Clonidine; Double-Blind Method; Epinephrine; Female; Huma | 1992 |
Partial attenuation of the pressor response to endotracheal intubation. A comparison of the effects of intravenous clonidine and fentanyl.
Topics: Adult; Blood Pressure; Clonidine; Double-Blind Method; Female; Fentanyl; Heart Rate; Humans; Injecti | 1992 |
Intrathecal clonidine as a sole analgesic for pain relief after cesarean section.
Topics: Adult; Analgesia, Obstetrical; Cesarean Section; Clonidine; Double-Blind Method; Female; Humans; Inj | 1992 |
Extradural clonidine infusions for analgesia after total hip replacement.
Topics: Adult; Aged; Analgesia, Epidural; Blood Pressure; Clonidine; Double-Blind Method; Drug Therapy, Comb | 1992 |
Intraoperative clonidine enhances postoperative morphine patient-controlled analgesia.
Topics: Adult; Age Factors; Aged; Analgesia, Patient-Controlled; Anesthesia, Inhalation; Anesthesia, Intrave | 1992 |
Epidural clonidine after cesarean section. Appropriate dose and effect of prior local anesthetic.
Topics: Adult; Analgesia, Epidural; Anesthesia, Epidural; Anesthesia, Obstetrical; Anesthetics, Local; Bupiv | 1992 |
Extradural clonidine does not potentiate analgesia produced by extradural morphine after meniscectomy.
Topics: Adult; Analgesia, Epidural; Clonidine; Drug Synergism; Female; Humans; Male; Menisci, Tibial; Morphi | 1991 |
Effect of epidural clonidine on analgesia and pharmacokinetics of epidural fentanyl in postoperative patients.
Topics: Aged; Analgesia, Epidural; Anesthesia, Epidural; Anesthesia, General; Clonidine; Evaluation Studies | 1991 |
Postoperative analgesia by intravenous clonidine.
Topics: Clonidine; Double-Blind Method; Female; Hemodynamics; Humans; Injections, Intravenous; Male; Middle | 1991 |
Clonidine decreases postoperative oxygen consumption in patients recovering from general anaesthesia.
Topics: Adult; Anesthesia Recovery Period; Anesthesia, General; Carbon Dioxide; Clonidine; Female; Humans; M | 1991 |
Clinical efficacy of oral-transdermal clonidine combinations during the perioperative period.
Topics: Adjuvants, Anesthesia; Administration, Cutaneous; Administration, Oral; Adult; Aged; Alfentanil; Ane | 1991 |
Comparison of epidural sufentanil plus clonidine with sufentanil alone for postoperative pain relief.
Topics: Adult; Analgesics; Blood Pressure; Clonidine; Double-Blind Method; Drug Therapy, Combination; Female | 1990 |
Clonidine-induced analgesia in postoperative patients: epidural versus intramuscular administration.
Topics: Adult; Aged; Analgesia; Analgesia, Epidural; Clonidine; Female; Hemodynamics; Humans; Injections, In | 1990 |
Addition of clonidine enhances postoperative analgesia from epidural morphine: a double-blind study.
Topics: Adult; Aged; Analgesia, Epidural; Clonidine; Double-Blind Method; Drug Combinations; Drug Synergism; | 1990 |
Comparison of the effects of extradural clonidine with those of morphine on postoperative pain, stress responses, cardiopulmonary function and motor and sensory block.
Topics: Adult; Analgesia, Epidural; Blood Glucose; Blood Pressure; Carbon Dioxide; Clonidine; Double-Blind M | 1989 |
Postoperative analgesia with extradural clonidine.
Topics: Adult; Analgesia, Epidural; Clonidine; Double-Blind Method; Female; Hemodynamics; Humans; Male; Pain | 1989 |
Epidural clonidine for treatment of postoperative pain after thoracotomy. A double-blind placebo-controlled study.
Topics: Adult; Aged; Clinical Trials as Topic; Clonidine; Double-Blind Method; Female; Humans; Injections, E | 1988 |
Oral premedication with clonidine: effects on stress responses during general anaesthesia.
Topics: Administration, Oral; Adult; Aged; Anesthesia, Endotracheal; Anesthesia, General; Anxiety; Catechola | 1987 |
73 other studies available for clonidine and Pain, Postoperative
| Article | Year |
|---|---|
Oral clonidine as a pre-anesthetic medication in hair transplantation surgery-A pilot study.
Topics: Adrenergic alpha-Agonists; Anesthetics, Local; Clonidine; Double-Blind Method; Hair; Humans; Pain, P | 2022 |
Effects of opioid-free anesthesia on postoperative morphine consumption after bariatric surgery.
Topics: Analgesics, Opioid; Anesthesia; Bariatric Surgery; Clonidine; Dexmedetomidine; Humans; Morphine; Pai | 2022 |
Postinterventional Patient Comfort After Uterine Artery Embolization and Superior Hypogastric Nerve Block.
Topics: Analgesics, Opioid; Anesthetics, Local; Clonidine; Female; Humans; Nerve Block; Pain; Pain, Postoper | 2023 |
Ropivacaine-Epinephrine-Clonidine-Ketorolac Cocktail as a Local Anesthetic for Lumbar Decompression Surgery: A Single Institutional Experience.
Topics: Adolescent; Adult; Analgesics, Opioid; Anesthetics, Local; Clonidine; Decompression; Epinephrine; GP | 2023 |
Evaluation of Gabapentin and Clonidine Use in Children Following Spinal Fusion Surgery for Idiopathic Scoliosis: A Retrospective Review.
Topics: Adolescent; Analgesia, Patient-Controlled; Analgesics, Opioid; Child; Clonidine; Female; Gabapentin; | 2019 |
[Intracerebroventricular infusion of morphine, bupivacaine and clonidine for the management of refractory neoplasic pain in a palliative care setting : a case report].
Topics: Analgesics, Opioid; Bupivacaine; Clonidine; Humans; Infusions, Intraventricular; Male; Morphine; Pai | 2021 |
Reply to the correspondence in relation to the article "Randomized study of post-cesarean analgesia with intrathecal morphine alone or combined with clonidine".
Topics: Analgesia; Analgesics, Opioid; Cesarean Section; Clonidine; Female; Humans; Injections, Spinal; Morp | 2017 |
Use of epidural clonidine for the management of analgesia in the opioid addicted parturient on buprenorphine maintenance therapy: an observational study.
Topics: Adrenergic alpha-Agonists; Adult; Analgesia, Epidural; Analgesia, Obstetrical; Buprenorphine; Cathet | 2018 |
Letter: Bupivacaine Field Block With Clonidine for Postoperative Pain Control in Posterior Spine Approaches: A Randomized Double-Blind Trial.
Topics: Anesthetics, Local; Bupivacaine; Clonidine; Double-Blind Method; Humans; Pain, Postoperative | 2018 |
In Reply: Bupivacaine Field Block With Clonidine for Postoperative Pain Control in Posterior Spine Approaches: A Randomized Double-Blind Trial.
Topics: Anesthetics, Local; Bupivacaine; Clonidine; Double-Blind Method; Humans; Pain, Postoperative | 2018 |
Combined Superficial and Deep Serratus Plane Block With Bupivacaine, Dexamethasone, and Clonidine in the Treatment of a Patient With Postmastectomy Pain Syndrome: A Case Report.
Topics: Adult; Analgesics; Anesthetics; Bupivacaine; Chronic Pain; Clonidine; Dexamethasone; Drug Therapy, C | 2018 |
Pain management in living related adult donor hepatectomy: feasibility of an evidence-based protocol in 100 consecutive donors.
Topics: Adult; Analgesia, Epidural; Anesthesia, Intravenous; Anesthetics; Clonidine; Evidence-Based Medicine | 2018 |
Pain management in living related adult donor hepatectomy: feasibility of an evidence-based protocol in 100 consecutive donors.
Topics: Adult; Analgesia, Epidural; Anesthesia, Intravenous; Anesthetics; Clonidine; Evidence-Based Medicine | 2018 |
Pain management in living related adult donor hepatectomy: feasibility of an evidence-based protocol in 100 consecutive donors.
Topics: Adult; Analgesia, Epidural; Anesthesia, Intravenous; Anesthetics; Clonidine; Evidence-Based Medicine | 2018 |
Pain management in living related adult donor hepatectomy: feasibility of an evidence-based protocol in 100 consecutive donors.
Topics: Adult; Analgesia, Epidural; Anesthesia, Intravenous; Anesthetics; Clonidine; Evidence-Based Medicine | 2018 |
ESPA pain management ladder: Caudal clonidine and cost/benefit considerations.
Topics: Anesthesia, Caudal; Anesthesiology; Bupivacaine; Child; Clonidine; Humans; Pain Management; Pain, Po | 2019 |
Effect of opioid-free anaesthesia on postoperative epidural ropivacaine requirement after thoracic surgery: A retrospective unmatched case-control study.
Topics: Aged; Analgesia, Epidural; Analgesics, Non-Narcotic; Analgesics, Opioid; Anesthetics, Local; Case-Co | 2019 |
Reply to Haydar, Bishr; Holman, Ashlee; Galante, Dario, regarding their comment "ESPA pain management ladder: Caudal clonidine and cost/benefit considerations".
Topics: Anesthesia, Caudal; Anesthesiology; Bupivacaine; Child; Clonidine; Humans; Pain Management; Pain, Po | 2019 |
Enteral absorption and haemodynamic response of clonidine in infants post-cardiac surgery.
Topics: Analgesics, Non-Narcotic; Analgesics, Opioid; Clonidine; Drug Administration Schedule; Heart Defects | 2014 |
Clinical benchmarks regarding multimodal peripheral nerve blocks for postoperative analgesia: observations regarding combined perineural midazolam-clonidine-buprenorphine-dexamethasone.
Topics: Analgesics; Benchmarking; Buprenorphine; Clonidine; Dexamethasone; Drug Therapy, Combination; Humans | 2015 |
Research priorities regarding multimodal peripheral nerve blocks for postoperative analgesia and anesthesia based on hospital quality data extracted from over 1,300 cases (2011-2014).
Topics: Analgesics; Buprenorphine; Clonidine; Dexamethasone; Drug Therapy, Combination; Humans; Midazolam; N | 2015 |
Does clonidine premedication decrease postoperative pain in children?
Topics: Adrenergic alpha-2 Receptor Agonists; Analgesics; Clonidine; Humans; Pain, Postoperative; Preanesthe | 2016 |
Continuous chest wall ropivacaine infusion for analgesia in children undergoing Nuss procedure: a comparison with thoracic epidural.
Topics: Adolescent; Amides; Amines; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Anesthesi | 2016 |
Single-shot thoracic epidural: an aid to earlier discharge for pediatric laparoscopic cholecystectomy.
Topics: Analgesics; Anesthesia, Epidural; Anesthetics, Local; Bupivacaine; Child; Cholecystectomy, Laparosco | 2016 |
Caudal analgesia and cardiothoracic surgery: a look at postoperative pain scores in a pediatric population.
Topics: Adolescent; Analgesics; Analgesics, Opioid; Anesthesia, Caudal; Anesthetics, Local; Bupivacaine; Car | 2016 |
Dexamethasone and Clonidine, but not Epinephrine, Prolong Duration of Ropivacaine Brachial Plexus Blocks, Cross-Sectional Analysis in Outpatient Surgery Setting.
Topics: Adult; Aged; Ambulatory Surgical Procedures; Amides; Analgesics; Anesthetics, Local; Brachial Plexus | 2017 |
The effect of serratus plane block performed under direct vision on postoperative pain in breast surgery.
Topics: Analgesics; Anesthesia, Local; Anesthetics, Local; Breast Neoplasms; Bupivacaine; Clonidine; Female; | 2016 |
Correspondence in relation to article by Carvalho FA et al. "randomized study of postcesarean analgesia with intrathecal morphine alone or combined with clonidine".
Topics: Analgesia; Clonidine; Double-Blind Method; Humans; Injections, Spinal; Morphine; Pain Management; Pa | 2017 |
Case report: postoperative analgesia and preserved motor function with clonidine and buprenorphine via a sciatic perineural catheter.
Topics: Adolescent; Analgesics; Anesthetics, Local; Bupivacaine; Clonidine; Humans; Knee Joint; Male; Middle | 2009 |
The sciatic nerve should be blocked to optimize postoperative analgesia after knee arthroplasty.
Topics: Amides; Analgesics; Anesthetics, Local; Arthroplasty, Replacement, Knee; Clonidine; Humans; Nerve Bl | 2009 |
Re: Addition of clonidine or dexmedetomidine to bupivacaine prolongs caudal analgesia in children.
Topics: Adrenergic alpha-Agonists; Analgesia, Epidural; Bupivacaine; Child; Clonidine; Dexmedetomidine; Huma | 2009 |
A prospective survey of patient-controlled epidural analgesia with bupivacaine and clonidine after total hip replacement: a pre- and postchange comparison with bupivacaine and hydromorphone in 1,000 patients.
Topics: Adrenergic alpha-Agonists; Aged; Analgesia, Epidural; Analgesia, Patient-Controlled; Analgesics, Opi | 2011 |
A comparative clinical study of injection clonidine versus midazolam in supraclavicular brachial plexus block for sedation and postoperative analgesia.
Topics: Analgesics; Brachial Plexus; Clonidine; Conscious Sedation; Humans; Hypnotics and Sedatives; Midazol | 2011 |
Multimodal analgesia including infraclavicular block in perioperative management of upper extremity amputation in neonate.
Topics: Acetaminophen; Amputation, Surgical; Analgesia; Analgesics, Non-Narcotic; Analgesics, Opioid; Anesth | 2011 |
Opioid-free perioperative analgesia for hemicolectomy in a patient with opioid-induced delirium: a case report and review of the analgesic efficacy of the alpha-2 agonist agents.
Topics: Abdominal Abscess; Adrenergic alpha-2 Receptor Agonists; Analgesia, Epidural; Analgesics, Non-Narcot | 2012 |
Ankle joint mobilization affects postoperative pain through peripheral and central adenosine A1 receptors.
Topics: Adenosine; Analysis of Variance; Animals; Ankle Joint; Caffeine; Clonidine; Disease Models, Animal; | 2013 |
Spinal adrenergic and cholinergic receptor interactions activated by clonidine in postincisional pain.
Topics: Adrenergic alpha-Agonists; Analgesics; Animals; Clonidine; Dose-Response Relationship, Drug; Injecti | 2003 |
Sedative effects of morphine and clonidine.
Topics: Analgesia, Patient-Controlled; Analgesics; Clonidine; Consciousness; Humans; Morphine; Pain, Postope | 2003 |
A long-term continuous infusion via a sciatic catheter in a 3-year-old boy.
Topics: Amides; Analgesics; Anesthetics, Local; Catheters, Indwelling; Child, Preschool; Clonidine; Foot; Hu | 2003 |
Intrathecal clonidine and severe hypotension after cardiopulmonary bypass.
Topics: Adrenergic alpha-Agonists; Cardiopulmonary Bypass; Clonidine; Hemodynamics; Humans; Hypotension; Inj | 2003 |
Postoperative pain and analgesic responses are similar in male and female Sprague-Dawley rats.
Topics: Acetates; Amines; Analgesics; Analgesics, Opioid; Animals; Behavior, Animal; Cholinesterase Inhibito | 2003 |
Dexmedetomidine in pediatrics: controlled studies needed.
Topics: Adolescent; Adult; Analgesics, Non-Narcotic; Child; Child Behavior; Child, Preschool; Clonidine; Dex | 2004 |
[Open heart tricuspid valve replacement in a heroin addict Anaesthesiological management].
Topics: Adrenergic alpha-Agonists; Adult; Amides; Anesthesia, Epidural; Anesthesia, General; Anesthetics, In | 2005 |
Clonidine as adjuvant for bupivacaine in ilioinguinal block does not prolong postoperative analgesia in pediatric and also in adult patients.
Topics: Adjuvants, Anesthesia; Adult; Aged; Analgesics; Anesthetics, Local; Bupivacaine; Child; Clonidine; H | 2006 |
Epidural clonidine for total hip replacement.
Topics: Analgesia, Epidural; Analgesics; Arthroplasty, Replacement, Hip; Clonidine; Evidence-Based Medicine; | 2006 |
Depression, night terrors, and insomnia associated with long-term intrathecal clonidine therapy.
Topics: Aged; Analgesics; Aortic Aneurysm, Thoracic; Catheterization; Clonidine; Humans; Male; Neuritis; Pai | 2007 |
The efficacy of postoperative perineural infusion of bupivacaine and clonidine after lower extremity amputation in preventing phantom limb and stump pain.
Topics: Adjuvants, Anesthesia; Aged, 80 and over; Amputation Stumps; Analgesia, Epidural; Analgesics; Bupiva | 2007 |
Effects of topical application of clonidine cream on pain behaviors and spinal Fos protein expression in rat models of neuropathic pain, postoperative pain, and inflammatory pain.
Topics: Administration, Topical; Analgesics; Animals; Behavior, Animal; Clonidine; Disease Models, Animal; D | 2007 |
Postoperative analgesia.
Topics: Analgesia; Clonidine; Female; Humans; Injections, Spinal; Pain, Postoperative; Pregnancy | 1995 |
[How can we improve the efficacy of morphine analgesia without increasing adverse effects?].
Topics: Analgesia, Epidural; Analgesia, Patient-Controlled; Anesthetics, Local; Anti-Inflammatory Agents, No | 1994 |
[Analgesia and hemodynamics under 8 mu/kg clonidine for pain therapy following major abdominal surgery].
Topics: Abdomen; Aged; Blood Pressure; Cardiac Output; Clonidine; Dose-Response Relationship, Drug; Heart Ra | 1994 |
[Temporary relief from pain in the phantom limb after spinal anesthesia using a combination of bupivacaine and clonidine].
Topics: Aged; Amputation, Surgical; Anesthesia, Spinal; Bupivacaine; Clonidine; Drug Therapy, Combination; H | 1993 |
[Postoperative analgesia with epidural administration of a combination of tramadol and clonidine].
Topics: Adrenergic alpha-Agonists; Analgesia, Epidural; Analgesics, Opioid; Clonidine; Humans; Pain, Postope | 1995 |
Extradural clonidine for postoperative pain relief.
Topics: Adult; Child; Clonidine; Humans; Injections, Epidural; Morphine; Pain Measurement; Pain, Postoperati | 1996 |
The use of intrapleural clonidine for postoperative pain control.
Topics: Adult; Analgesics; Antihypertensive Agents; Catheters, Indwelling; Cholecystectomy; Clonidine; Femal | 1996 |
Extradural clonidine for postoperative pain relief.
Topics: Adrenergic alpha-Agonists; Anesthesia, Epidural; Child, Preschool; Clonidine; Humans; Pain, Postoper | 1996 |
The role of clonidine and alpha 2-agonists for postoperative analgesia.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-Agonists; Clonidine; Humans; Pain, Postoperat | 1996 |
Oral clonidine and postoperative pain.
Topics: Administration, Oral; Adolescent; Child; Clonidine; Humans; Pain Measurement; Pain, Postoperative | 1997 |
Plasma levels of clonidine following epidural bolus injection in children.
Topics: Adrenergic alpha-Agonists; Analgesia, Epidural; Anesthesia, General; Anesthetics, Local; Bupivacaine | 1998 |
[Epidural fentanyl: legal, illegal, does it matter? Remarks on the work of J. Jage and H. Hartje. Postoperative pain therapy, Part II. Anaesthesist (1997) 46:161-173].
Topics: Adrenergic alpha-Agonists; Analgesia, Epidural; Analgesics, Opioid; Clonidine; Fentanyl; Germany; Hu | 1998 |
[Analgesia by continuous tibial nerve block after ischemia and amputation].
Topics: Aged; Amputation, Surgical; Analgesia; Bupivacaine; Clonidine; Humans; Ischemia; Leg; Male; Nerve Bl | 1997 |
-Postoperative analgesia after major surgery of the knee.
Topics: Acetaminophen; Analgesia; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Anesthetics | 1998 |
Intrathecal adenosine: interactions with spinal clonidine and neostigmine in rat models of acute nociception and postoperative hypersensitivity.
Topics: Adenosine; Analgesics, Non-Narcotic; Animals; Clonidine; Disease Models, Animal; Dose-Response Relat | 1999 |
Effects of intrathecal administration of ziconotide, a selective neuronal N-type calcium channel blocker, on mechanical allodynia and heat hyperalgesia in a rat model of postoperative pain.
Topics: Analgesics; Analgesics, Opioid; Animals; Calcium Channel Blockers; Calcium Channels, N-Type; Clonidi | 2000 |
Antiallodynic effect of intrathecal gabapentin and its interaction with clonidine in a rat model of postoperative pain.
Topics: Acetates; Adrenergic alpha-Agonists; Amines; Amino Acids; Amino Acids, Cyclic; Analgesics; Animals; | 2000 |
The mechanical antihyperalgesic effect of intrathecally administered MPV-2426, a novel alpha2 -adrenoceptor agonist, in a rat model of postoperative pain.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-Agonists; Animals; Clonidine; Dexmedetomidine | 2000 |
The efficacy and safety of epidural infusions of levobupivacaine with and without clonidine for postoperative pain relief in patients undergoing total hip replacement.
Topics: Aged; Analgesia, Epidural; Analgesics; Analgesics, Opioid; Anesthetics, Local; Arthroplasty, Replace | 2000 |
Systemic tizanidine hydrochloride (Zanaflex) partially decreases experimental postoperative pain in rats.
Topics: Adrenergic alpha-Agonists; Analgesics; Animals; Clonidine; Disease Models, Animal; Male; Pain, Posto | 2001 |
Pharmacokinetics of clonidine after epidural administration in surgical patients. Lack of correlation between plasma concentration and analgesia and blood pressure changes.
Topics: Adult; Analgesia, Epidural; Blood Pressure; Clonidine; Female; Humans; Hysterectomy; Middle Aged; Pa | 1992 |
[Postoperative analgesia with intravenous clonidine].
Topics: Adolescent; Adult; Clonidine; Humans; Injections, Intravenous; Pain, Postoperative | 1989 |
[Postoperative peridural analgesia with clonidine].
Topics: Clonidine; Humans; Injections, Epidural; Middle Aged; Pain, Postoperative | 1989 |
[Postoperative analgesia induced with peridural clonidine].
Topics: Clonidine; Humans; Injections, Epidural; Pain, Postoperative | 1989 |
[Postoperative analgesia induced by clonidine: comparison of peridural and IM administration].
Topics: Clonidine; Humans; Injections, Epidural; Injections, Intramuscular; Pain, Postoperative | 1989 |
[Clinical effects of the addition of clonidine with and without adrenaline with peridural administration of lidocaine].
Topics: Anesthesia, Epidural; Clonidine; Epinephrine; Humans; Lidocaine; Pain, Postoperative | 1989 |
Epidural clonidine analgesia following surgery: phase I.
Topics: Analgesia, Epidural; Blood Pressure; Clonidine; Dose-Response Relationship, Drug; Female; Heart Rate | 1989 |
Clinical study on epidural clonidine for postoperative analgesia.
Topics: Adult; Blood Pressure; Catheters, Indwelling; Clonidine; Epidural Space; Humans; Middle Aged; Pain, | 1986 |