clonidine has been researched along with Pain, Intractable in 25 studies
Clonidine: An imidazoline sympatholytic agent that stimulates ALPHA-2 ADRENERGIC RECEPTORS and central IMIDAZOLINE RECEPTORS. It is commonly used in the management of HYPERTENSION.
clonidine (amino form) : A clonidine that is 4,5-dihydro-1H-imidazol-2-amine in which one of the amino hydrogens is replaced by a 2,6-dichlorophenyl group.
Pain, Intractable: Persistent pain that is refractory to some or all forms of treatment.
| Excerpt | Relevance | Reference |
|---|---|---|
| " We present the case of the youngest reported child to have received intrathecal analgesia for terminal care: a 3-year-old boy with advanced pelvic rhabdomyosarcoma, whose refractory pain was managed effectively with an intrathecal infusion of bupivacaine and preservative-free clonidine." | 3.78 | Intrathecal infusion of bupivacaine and clonidine provides effective analgesia in a terminally ill child. ( Lauder, G; Whyte, E, 2012) |
| " Despite leptomeningeal infection during prolonged treatment, epidural analgesia at the lumbar level provided analgesia using very large doses of local anesthetics combined with clonidine and morphine." | 3.72 | Epidural analgesia at end of life: facing empirical contraindications. ( Eikermann, M; Exner, HJ; Peters, J, 2003) |
| "Eighty-five patients with severe cancer pain despite large doses of opioids or with therapy-limiting side effects from opioids were randomized to receive, in a double-blind manner, 30 micrograms/h epidural clonidine or placebo for 14 days, together with rescue epidural morphine." | 2.68 | Epidural clonidine analgesia for intractable cancer pain. The Epidural Clonidine Study Group. ( Allin, D; Dubois, M; DuPen, S; Eisenach, JC; Miguel, R, 1995) |
| "In most cases, drug-related spinal cord injuries have resulted from the compression of a spinal inflammatory mass or abcess rather than from a direct neurotoxic effect." | 1.32 | Spinal cord lesion after long-term intrathecal clonidine and bupivacaine treatment for the management of intractable pain. ( Buchser, E; Chédel, D; Hirt, L; Maeder, P; Perren, F; Vingerhoets, F, 2004) |
| "Clonidine was added to baclofen in the pump reservoir and both drugs were administered intrathecally in combination." | 1.29 | Intrathecal clonidine and baclofen in the management of spasticity and neuropathic pain following spinal cord injury: a case study. ( Middleton, JW; Molloy, AR; Rutkowski, SB; Siddall, PJ; Walker, S, 1996) |
| "Clonidine was absorbed in a dose-dependent manner into the systemic circulation, although absorption and elimination kinetics were highly variable." | 1.28 | Epidural clonidine analgesia for intractable cancer pain: phase I. ( Buzzanell, C; Eisenach, JC; Lysak, SZ; Rauck, RL, 1989) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 8 (32.00) | 18.7374 |
| 1990's | 6 (24.00) | 18.2507 |
| 2000's | 8 (32.00) | 29.6817 |
| 2010's | 2 (8.00) | 24.3611 |
| 2020's | 1 (4.00) | 2.80 |
| Authors | Studies |
|---|---|
| Michot, T | 1 |
| Duysinx, P | 1 |
| Belle, F | 1 |
| Dresse, C | 1 |
| Montupil, J | 1 |
| Bonhomme, V | 1 |
| Defresne, A | 1 |
| Pirbudak, L | 1 |
| Sevinç, A | 1 |
| Maralcan, G | 1 |
| Kılıç, E | 1 |
| Taira, T | 1 |
| Whyte, E | 1 |
| Lauder, G | 1 |
| Exner, HJ | 1 |
| Peters, J | 1 |
| Eikermann, M | 1 |
| Perren, F | 1 |
| Buchser, E | 1 |
| Chédel, D | 1 |
| Hirt, L | 1 |
| Maeder, P | 1 |
| Vingerhoets, F | 1 |
| Taha, J | 1 |
| Favre, J | 1 |
| Janszen, M | 1 |
| Galarza, M | 1 |
| Taha, A | 1 |
| Benrath, J | 1 |
| Scharbert, G | 1 |
| Gustorff, B | 1 |
| Adams, HA | 1 |
| Kress, HG | 1 |
| Giri, S | 1 |
| Nixdorf, D | 1 |
| Tamsen, A | 1 |
| Gordh, T | 1 |
| Bakris, GL | 1 |
| Charney, DS | 1 |
| Kleber, HD | 1 |
| Eisenach, JC | 2 |
| DuPen, S | 2 |
| Dubois, M | 1 |
| Miguel, R | 1 |
| Allin, D | 1 |
| Siegemund, M | 1 |
| Schneider, MC | 1 |
| Hampl, KF | 1 |
| Hösli, I | 1 |
| Ricci, V | 1 |
| Dalpane, A | 1 |
| Lolli, E | 1 |
| Fitzgibbon, D | 1 |
| Rapp, S | 1 |
| Butler, S | 1 |
| Terman, G | 1 |
| Dolack, G | 1 |
| Ready, LB | 1 |
| Middleton, JW | 1 |
| Siddall, PJ | 1 |
| Walker, S | 1 |
| Molloy, AR | 1 |
| Rutkowski, SB | 1 |
| Mercadante, S | 1 |
| Serretta, R | 1 |
| Sapio, M | 1 |
| Villari, P | 1 |
| Calderone, L | 1 |
| Covey, WC | 1 |
| Ignatowski, TA | 1 |
| Knight, PR | 1 |
| Spengler, RN | 1 |
| Leong, MS | 1 |
| Calabrese, JF | 1 |
| Heit, G | 1 |
| Coombs, DW | 2 |
| Saunders, RL | 2 |
| Fratkin, JD | 1 |
| Jensen, LE | 2 |
| Murphy, CA | 1 |
| Rauck, RL | 1 |
| Buzzanell, C | 1 |
| Lysak, SZ | 1 |
| Krames, ES | 1 |
| Wilkie, DJ | 1 |
| Gershow, J | 1 |
| van Essen, EJ | 1 |
| Bovill, JG | 1 |
| Ploeger, EJ | 1 |
| Beerman, H | 1 |
| Lachance, D | 1 |
| Savage, S | 1 |
| Ragnarsson, TS | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Hemodynamic Effect of Intrathecal Clonidine in Hypertensive Subjects: A Pilot Study to Assess Its Effectiveness in Hypertensive Subjects With Poor Blood Pressure Control (Phase II)[NCT01297335] | Phase 2 | 10 participants (Actual) | Interventional | 2011-02-28 | Completed | ||
| Clinical Trial of Etanercept (TNF-α Blocker) for Treatment of Blast-Induced Tinnitus[NCT04066348] | Phase 2 | 310 participants (Anticipated) | Interventional | 2022-07-01 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
"Subjects baseline blood pressure (systolic blood pressure (SBP), and diastolic blood pressure (DBP)), and blood pressures after clonidine injection was compared against baseline to assess efficacy of clonidine in refractory hypertensive subjects. Subject's blood pressure was monitored continuously after intrathecal injection of clonidine until subjects blood pressure nadir and return to pre clonidine injection level. The mean value reported below are the average changes in blood pressure from baseline (pre clonidine injection) in both SBP and DBP during post clonidine injection blood pressure monitoring for 4 hours.~Blood pressure measurements were collected every 10 minutes for first hour after injection, and every 15 minutes after the first hour, up to 4 hours were averaged to report the change from baseline." (NCT01297335)
Timeframe: Baseline, Every 10 Minutes for first hour after clonidine injection, and every 15 minutes after first hour, until 4 hours after clonidine injection
| Intervention | mm Hg (Mean) | |
|---|---|---|
| Change in mean SBP after clonidine injection | Change in DBP after clonidine injection | |
| Intrathecal Clonidine | 79 | 37 |
Subjects were asked to rate severity of two of the most common side effects of clonidine, sedation and sensation of dry mouth, at pre and post (1 hour after) intrathecal administration of clonidine. The mean changes between pre and post injection VAS ratings of sedation and sensation of dry mouth are reported below. The VAS scale ranges from 1 to 10 cm, with higher values indicating higher level of sedation and higher level of dry mouth. (NCT01297335)
Timeframe: Before clonidine injection (Baseline), and at 1 hour after clonidine injection.
| Intervention | cm (Mean) | |
|---|---|---|
| Change in level of sedation | Change in sensation of dry mouth | |
| Intrathecal Clonidine | 3.36 | 3.47 |
Likert scale is 11 point digital pain rating system that asks subjects to rate their pain from 0 to 10. Rating of 0 means no pain at all, and in increasing order, 10 would mean worst pain imaginable/ unbearable pain. (NCT01297335)
Timeframe: Pre-dose and 1 hour post injection.
| Intervention | units on a scale (Mean) | |
|---|---|---|
| Pre-injection average Likert score | Post-injection average Likert score | |
| Intrathecal Clonidine | 6.5 | 3.6 |
2 reviews available for clonidine and Pain, Intractable
| Article | Year |
|---|---|
[Chronic intrathecal drug administration for the control of intractable pain].
Topics: Amines; Analgesics, Opioid; Anesthetics, Local; Baclofen; Calcium Channel Blockers; Clonidine; Cyclo | 2008 |
[Continuous spinal analgesia in home care of oncologic pain].
Topics: Analgesics, Opioid; Bupivacaine; Clonidine; Home Infusion Therapy; Humans; Infusion Pumps, Implantab | 1995 |
1 trial available for clonidine and Pain, Intractable
| Article | Year |
|---|---|
Epidural clonidine analgesia for intractable cancer pain. The Epidural Clonidine Study Group.
Topics: Adult; Aged; Aged, 80 and over; Analgesia, Epidural; Analgesics, Opioid; Analysis of Variance; Cloni | 1995 |
22 other studies available for clonidine and Pain, Intractable
| Article | Year |
|---|---|
[Intracerebroventricular infusion of morphine, bupivacaine and clonidine for the management of refractory neoplasic pain in a palliative care setting : a case report].
Topics: Analgesics, Opioid; Bupivacaine; Clonidine; Humans; Infusions, Intraventricular; Male; Morphine; Pai | 2021 |
Pain management with intrathecal clonidine in a colon cancer patient with opioid hyperalgesia: case presentation.
Topics: Adult; Analgesics; Clonidine; Colonic Neoplasms; Diagnosis, Differential; Humans; Injections, Spinal | 2014 |
Intrathecal infusion of bupivacaine and clonidine provides effective analgesia in a terminally ill child.
Topics: Adrenergic alpha-Agonists; Anesthetics, Local; Bupivacaine; Clonidine; Fatal Outcome; Humans; Infant | 2012 |
Epidural analgesia at end of life: facing empirical contraindications.
Topics: Abdominal Pain; Adrenergic alpha-Agonists; Adult; Analgesia, Epidural; Analgesics, Opioid; Anestheti | 2003 |
Spinal cord lesion after long-term intrathecal clonidine and bupivacaine treatment for the management of intractable pain.
Topics: Analgesia, Epidural; Analgesics; Bupivacaine; Clonidine; Humans; Infusion Pumps, Implantable; Longit | 2004 |
Correlation between withdrawal symptoms and medication pump residual volume in patients with implantable SynchroMed pumps.
Topics: Adult; Aged; Aged, 80 and over; Analgesia, Epidural; Analgesics, Opioid; Baclofen; Bupivacaine; Clon | 2004 |
Long-term intrathecal S(+)-ketamine in a patient with cancer-related neuropathic pain.
Topics: Analgesics; Clonidine; Drug Tolerance; Humans; Injections, Spinal; Ketamine; Lumbar Vertebrae; Male; | 2005 |
Sympathetically maintained pain presenting first as temporomandibular disorder, then as parotid dysfunction.
Topics: Adrenergic alpha-Agonists; Adult; Anesthetics, Local; Autonomic Nervous System Diseases; Bupivacaine | 2007 |
Epidural clonidine produces analgesia.
Topics: Adult; Clonidine; Female; Humans; Injections, Spinal; Male; Middle Aged; Pain, Intractable | 1984 |
Clonidine for opiate withdrawal in the chronic pain patient.
Topics: Clonidine; Humans; Opioid-Related Disorders; Pain, Intractable; Receptors, Opioid; Substance Withdra | 1982 |
Iatrogenic opiate addiction: successful detoxification with clonidine.
Topics: Clonidine; Codeine; Female; Humans; Middle Aged; Opioid-Related Disorders; Oxycodone; Pain, Intracta | 1980 |
Epidural clonidine for relief from intractable labour pain.
Topics: Adult; Analgesia, Epidural; Analgesia, Obstetrical; Clonidine; Female; Humans; Labor, Obstetric; Pai | 1995 |
Rebound hypertension and withdrawal associated with discontinuation of an infusion of epidural clonidine.
Topics: Adenocarcinoma; Adrenergic alpha-Agonists; Clonidine; Humans; Hypertension; Male; Middle Aged; Pain, | 1996 |
Intrathecal clonidine and baclofen in the management of spasticity and neuropathic pain following spinal cord injury: a case study.
Topics: Adult; Baclofen; Clonidine; Female; Humans; Infusion Pumps, Implantable; Injections, Spinal; Muscle | 1996 |
When all else fails: stepwise multiple solutions for a complex cancer pain syndrome.
Topics: Aged; Analgesics; Analgesics, Opioid; Anesthetics, Local; Bupivacaine; Cholinesterase Inhibitors; Cl | 1999 |
Brain-derived TNFalpha: involvement in neuroplastic changes implicated in the conscious perception of persistent pain.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Brain; Chronic Disease; Clonidine; | 2000 |
Intraventricular administration of morphine and clonidine.
Topics: Adrenergic alpha-Agonists; Analgesics, Opioid; Brain Neoplasms; Breast Neoplasms; Carcinoma, Ductal, | 2001 |
Continuous intrathecal hydromorphone and clonidine for intractable cancer pain.
Topics: Carcinoma; Clonidine; Female; Humans; Hydromorphone; Injections, Spinal; Middle Aged; Pain, Intracta | 1986 |
Epidural clonidine analgesia for intractable cancer pain: phase I.
Topics: Analgesia, Epidural; Blood Pressure; Clonidine; Female; Heart Rate; Humans; Male; Middle Aged; Morph | 1989 |
Intrathecal D-Ala2-D-Leu5-enkephalin (DADL) restores analgesia in a patient analgetically tolerant to intrathecal morphine sulfate.
Topics: Aged; Carcinoma; Clonidine; Drug Tolerance; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Huma | 1986 |
Intrathecal morphine and clonidine for control of intractable cancer pain. A case report.
Topics: Carcinoma, Renal Cell; Clonidine; Drug Therapy, Combination; Humans; Infusion Pumps; Injections, Spi | 1988 |
Intrathecal morphine tolerance: use of intrathecal clonidine, DADLE, and intraventricular morphine.
Topics: Adenocarcinoma; Bupivacaine; Clonidine; Combined Modality Therapy; Double-Blind Method; Drug Therapy | 1985 |