Page last updated: 2024-10-25

clonidine and Osteogenesis Imperfecta

clonidine has been researched along with Osteogenesis Imperfecta in 2 studies

Clonidine: An imidazoline sympatholytic agent that stimulates ALPHA-2 ADRENERGIC RECEPTORS and central IMIDAZOLINE RECEPTORS. It is commonly used in the management of HYPERTENSION.
clonidine (amino form) : A clonidine that is 4,5-dihydro-1H-imidazol-2-amine in which one of the amino hydrogens is replaced by a 2,6-dichlorophenyl group.

Osteogenesis Imperfecta: COLLAGEN DISEASES characterized by brittle, osteoporotic, and easily fractured bones. It may also present with blue sclerae, loose joints, and imperfect dentin formation. Most types are autosomal dominant and are associated with mutations in COLLAGEN TYPE I.

Research

Studies (2)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	2 (100.00)	18.2507
2000's	0 (0.00)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Marini, JC	2
Bordenick, S	2
Chrousos, GP	2
Heavner, G	1
Rose, S	1
Hintz, R	1
Rosenfeld, R	1

Clinical Trials (2)

Trial Overview

Trial	Phase	Enrollment	Study Type	Start Date	Status
Studies of Growth Deficiency and Growth Hormone Treatment in Children With Osteogenesis Imperfecta Types III and IV[NCT00001305]	Phase 3	42 participants (Actual)	Interventional	1991-11-05	Completed
Evaluation and Intervention for Ambulation, Growth, and Basilar Invagination in Osteogenesis Imperfecta[NCT00001594]		88 participants (Actual)	Observational	1997-01-29	Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Proportion of Subjects Who Met Criteria of Increase in Growth Rate Since Baseline.

The proportion of subjects who met the study criteria of at least 50% increase in growth rate since baseline. (NCT00001305)
Timeframe: 1 year

Intervention	Participants (Count of Participants)
Growth Hormone	25

Trials

1 trial available for clonidine and Osteogenesis Imperfecta

Article	Year
Endocrine aspects of growth deficiency in OI. Connective tissue research, 1995, Volume: 31, Issue:4 Topics: Adolescent; Bone Diseases, Endocrine; Bone Matrix; Calcification, Physiologic; Child; Child, Prescho	1995

Other Studies

1 other study available for clonidine and Osteogenesis Imperfecta

Article	Year
The growth hormone and somatomedin axis in short children with osteogenesis imperfecta. The Journal of clinical endocrinology and metabolism, 1993, Volume: 76, Issue:1 Topics: Adolescent; Arginine; Body Height; Child; Child, Preschool; Clonidine; Female; Growth Disorders; Gro	1993
The growth hormone and somatomedin axis in short children with osteogenesis imperfecta. The Journal of clinical endocrinology and metabolism, 1993, Volume: 76, Issue:1 Topics: Adolescent; Arginine; Body Height; Child; Child, Preschool; Clonidine; Female; Growth Disorders; Gro	1993
The growth hormone and somatomedin axis in short children with osteogenesis imperfecta. The Journal of clinical endocrinology and metabolism, 1993, Volume: 76, Issue:1 Topics: Adolescent; Arginine; Body Height; Child; Child, Preschool; Clonidine; Female; Growth Disorders; Gro	1993
The growth hormone and somatomedin axis in short children with osteogenesis imperfecta. The Journal of clinical endocrinology and metabolism, 1993, Volume: 76, Issue:1 Topics: Adolescent; Arginine; Body Height; Child; Child, Preschool; Clonidine; Female; Growth Disorders; Gro	1993