clonidine has been researched along with Obsessive-Compulsive Disorder in 30 studies
Clonidine: An imidazoline sympatholytic agent that stimulates ALPHA-2 ADRENERGIC RECEPTORS and central IMIDAZOLINE RECEPTORS. It is commonly used in the management of HYPERTENSION.
clonidine (amino form) : A clonidine that is 4,5-dihydro-1H-imidazol-2-amine in which one of the amino hydrogens is replaced by a 2,6-dichlorophenyl group.
Obsessive-Compulsive Disorder: An anxiety disorder characterized by recurrent, persistent obsessions or compulsions. Obsessions are the intrusive ideas, thoughts, or images that are experienced as senseless or repugnant. Compulsions are repetitive and seemingly purposeful behavior which the individual generally recognizes as senseless and from which the individual does not derive pleasure although it may provide a release from tension.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To evaluate noradrenergic (NE) function in obsessive-compulsive disorder (OCD), behavioral, physiological, and neuroendocrine responses to the alpha 2-adrenergic agonist clonidine were examined in 18 patients with OCD and 10 healthy subjects." | 9.07 | Noradrenergic function in obsessive-compulsive disorder: behavioral and neuroendocrine responses to clonidine and comparison to healthy controls. ( Cooper, T; DeCaria, C; Gully, R; Hollander, E; Klein, DF; Liebowitz, MR; Nitescu, A; Stover, B, 1991) |
| "In 15 patients with obsessive-compulsive disorder (OCD) and in 15 healthy controls postsynaptic alpha-2-adrenoceptor sensitivity was examined by measuring the growth hormone (GH) response to growth hormone-releasing hormone (GHRH) and to clonidine stimulation." | 7.69 | Noradrenergic receptor sensitivity in obsessive-compulsive disorders: I. Growth hormone response to clonidine stimulation. ( Arancio, C; Bellodi, L; Bertani, A; Brambilla, F; Carraro, C; Gava, F; Perini, G; Perna, G, 1997) |
| "Clonazepam improvement was unrelated to changes in anxiety and occurred early in treatment." | 6.67 | Clomipramine, clonazepam, and clonidine treatment of obsessive-compulsive disorder. ( Agras, WS; Hewlett, WA; Vinogradov, S, 1992) |
| "To evaluate noradrenergic (NE) function in obsessive-compulsive disorder (OCD), behavioral, physiological, and neuroendocrine responses to the alpha 2-adrenergic agonist clonidine were examined in 18 patients with OCD and 10 healthy subjects." | 5.07 | Noradrenergic function in obsessive-compulsive disorder: behavioral and neuroendocrine responses to clonidine and comparison to healthy controls. ( Cooper, T; DeCaria, C; Gully, R; Hollander, E; Klein, DF; Liebowitz, MR; Nitescu, A; Stover, B, 1991) |
| " The study aimed to determine the risk of TBI in TS patients, the effects associated with concurrent psychiatric disorders (attention-deficit/hyperactivity disorder (ADHD), obsessive-compulsive disorder (OCD), or depressive disorder), and the effects of medication treatment (antipsychotics, antidepressants, or clonidine) on the risk of TBI." | 3.91 | Tourette's syndrome is associated with an increased risk of traumatic brain injury: A nationwide population-based cohort study. ( Chen, SF; Hsu, CY; Shen, YC; Su, YC; Wang, LY, 2019) |
| " We now report that these OCD-like mice, like humans, also exhibit comorbid TS-like behaviors, including juvenile-onset tics; increased tic number, complexity and flurries; increased tic severity in males; voluntary tic suppression; and tic responsiveness to a non-cataleptic TS+OCD drug therapy (clonidine, 0." | 3.71 | A transgenic model of comorbid Tourette's syndrome and obsessive-compulsive disorder circuitry. ( Burton, FH; Nordstrom, EJ, 2002) |
| "In 15 patients with obsessive-compulsive disorder (OCD) and in 15 healthy controls postsynaptic alpha-2-adrenoceptor sensitivity was examined by measuring the growth hormone (GH) response to growth hormone-releasing hormone (GHRH) and to clonidine stimulation." | 3.69 | Noradrenergic receptor sensitivity in obsessive-compulsive disorders: I. Growth hormone response to clonidine stimulation. ( Arancio, C; Bellodi, L; Bertani, A; Brambilla, F; Carraro, C; Gava, F; Perini, G; Perna, G, 1997) |
| "Sensitivity of pre-synaptic alpha-2- and post-synaptic alpha-1- and beta-adrenoceptors was investigated in 15 patients with obsessive-compulsive disorder (OCD) and in 15 age- and sex-matched healthy controls, by measuring cortisol responses to saline administration and to inhibition by clonidine (clon), a noradrenergic receptor agonist." | 3.69 | Noradrenergic receptor sensitivity in obsessive compulsive disorder: II. Cortisol response to acute clonidine administration. ( Arancio, C; Bellodi, L; Bertani, A; Brambilla, F; Carraro, C; Gava, F; Perini, G; Perna, G, 1997) |
| "Ten patients with obsessive-compulsive disorder (OCD) and 13 normal control subjects received intravenous infusions of 2 X 10(-6) g/kg of clonidine and normal saline on separate days." | 3.68 | Alpha 2-adrenoreceptor status in obsessive-compulsive disorder. ( Abelson, JL; Cameron, OG; Curtis, GC; Glitz, D; Gurguis, GN; Hariharan, M; Lee, MA; Smith, CB, 1990) |
| "We have observed a lesser growth hormone response to intravenous clonidine administration in nine obsessive-compulsive disorder patients meeting research diagnostic criteria than in nine matched controls." | 3.66 | Growth hormone response to clonidine in obsessive-compulsive patients. ( Aloi, J; Insel, TR; Jimerson, DC; Lake, CR; Murphy, DL; Siever, LJ; Uhde, TW, 1983) |
| "Clonazepam improvement was unrelated to changes in anxiety and occurred early in treatment." | 2.67 | Clomipramine, clonazepam, and clonidine treatment of obsessive-compulsive disorder. ( Agras, WS; Hewlett, WA; Vinogradov, S, 1992) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 11 (36.67) | 18.7374 |
| 1990's | 10 (33.33) | 18.2507 |
| 2000's | 6 (20.00) | 29.6817 |
| 2010's | 3 (10.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Jain, S | 1 |
| Gupta, T | 1 |
| Nebhinani, N | 1 |
| Singhai, K | 1 |
| Suthar, N | 1 |
| Chen, SF | 1 |
| Su, YC | 1 |
| Wang, LY | 1 |
| Hsu, CY | 1 |
| Shen, YC | 1 |
| Rickards, H | 1 |
| Cavanna, AE | 1 |
| Worrall, R | 1 |
| Nordstrom, EJ | 1 |
| Burton, FH | 1 |
| Suchard, JR | 1 |
| Graeme, KA | 1 |
| Listernick, R | 1 |
| Kano, Y | 1 |
| Kotcher, L | 1 |
| Wieland, N | 2 |
| Coffey, B | 2 |
| Leckman, JF | 1 |
| Cohen, DJ | 2 |
| Insel, TR | 4 |
| Mueller, EA | 1 |
| Gillin, JC | 1 |
| Siever, LJ | 4 |
| Murphy, DL | 5 |
| Jimerson, DC | 2 |
| Lake, CR | 2 |
| Uhde, TW | 2 |
| Aloi, J | 2 |
| Knesevich, JW | 1 |
| Ahsanuddin, K | 1 |
| Campbell, M | 1 |
| Cueva, JE | 1 |
| Como, PG | 1 |
| Singer, HS | 1 |
| Brambilla, F | 2 |
| Perna, G | 2 |
| Bellodi, L | 2 |
| Arancio, C | 2 |
| Bertani, A | 2 |
| Perini, G | 2 |
| Carraro, C | 2 |
| Gava, F | 2 |
| Peterson, BS | 1 |
| Hewlett, WA | 1 |
| Vinogradov, S | 1 |
| Agras, WS | 1 |
| Hollander, E | 3 |
| DeCaria, C | 1 |
| Nitescu, A | 1 |
| Cooper, T | 1 |
| Stover, B | 1 |
| Gully, R | 1 |
| Klein, DF | 1 |
| Liebowitz, MR | 3 |
| Bihari, K | 1 |
| Pato, MT | 1 |
| Hill, JL | 1 |
| Lee, MA | 1 |
| Cameron, OG | 1 |
| Gurguis, GN | 1 |
| Glitz, D | 1 |
| Smith, CB | 1 |
| Hariharan, M | 1 |
| Abelson, JL | 1 |
| Curtis, GC | 1 |
| Fay, M | 2 |
| Cohen, B | 1 |
| Campeas, R | 1 |
| Gorman, JM | 1 |
| Kaye, WH | 1 |
| Kafka, M | 1 |
| Targum, S | 1 |
| Caine, ED | 1 |
| McBride, MC | 1 |
| Chiverton, P | 1 |
| Bamford, KA | 1 |
| Rediess, S | 1 |
| Shiao, J | 1 |
| Lipsedge, MS | 1 |
| Prothero, W | 1 |
| Hamilton, JA | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| [NCT00004325] | 200 participants | Observational | 1988-12-31 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
6 reviews available for clonidine and Obsessive-Compulsive Disorder
| Article | Year |
|---|---|
[Chronic tic disorders--chronic mortor or vocal tic disorders and de la Tourette's syndrome].
Topics: Adolescent; Antidepressive Agents; Attention Deficit Disorder with Hyperactivity; Central Nervous Sy | 2003 |
Recent advances in Gilles de la Tourette syndrome: implications for clinical practice and future research.
Topics: Adolescent; Age Factors; Attention Deficit Disorder with Hyperactivity; Child; Clonidine; Compulsive | 1983 |
Psychopharmacology in child and adolescent psychiatry: a review of the past seven years. Part II.
Topics: Adolescent; Alprazolam; Anticonvulsants; Antipsychotic Agents; Anxiety, Separation; Bipolar Disorder | 1995 |
Obsessive-compulsive disorder in Tourette's syndrome.
Topics: Behavior Therapy; Clomipramine; Clonidine; Fluvoxamine; Humans; Obsessive-Compulsive Disorder; Toure | 1995 |
Tic disorders.
Topics: Antipsychotic Agents; Attention Deficit Disorder with Hyperactivity; Behavior Therapy; Child; Child | 1993 |
The treatment of Tourette's syndrome: multimodal, developmental intervention.
Topics: Adaptation, Psychological; Adolescent; Adrenergic Agonists; Adult; Age Factors; Antidepressive Agent | 1998 |
4 trials available for clonidine and Obsessive-Compulsive Disorder
| Article | Year |
|---|---|
Clomipramine, clonazepam, and clonidine treatment of obsessive-compulsive disorder.
Topics: Adult; Analysis of Variance; Anxiety; Clomipramine; Clonazepam; Clonidine; Depression; Double-Blind | 1992 |
Noradrenergic function in obsessive-compulsive disorder: behavioral and neuroendocrine responses to clonidine and comparison to healthy controls.
Topics: Adolescent; Adult; Affect; Anxiety; Behavior; Clonidine; Growth Hormone; Humans; Hydrocortisone; Met | 1991 |
Serotonergic and noradrenergic sensitivity in obsessive-compulsive disorder: behavioral findings.
Topics: Adult; Clonidine; Fenfluramine; Humans; Male; Middle Aged; Obsessive-Compulsive Disorder; Piperazine | 1988 |
Clonidine and clomipramine in obsessive-compulsive disorder.
Topics: Administration, Oral; Clinical Trials as Topic; Clomipramine; Clonidine; Double-Blind Method; Drug T | 1988 |
20 other studies available for clonidine and Obsessive-Compulsive Disorder
| Article | Year |
|---|---|
Therapeutic challenges in comorbid obsessive compulsive disorder with substance use.
Topics: Adrenergic alpha-2 Receptor Agonists; Clonazepam; Clonidine; Combined Modality Therapy; Fluoxetine; | 2018 |
Tourette's syndrome is associated with an increased risk of traumatic brain injury: A nationwide population-based cohort study.
Topics: Adolescent; Adult; Antidepressive Agents; Antipsychotic Agents; Attention Deficit Disorder with Hype | 2019 |
Treatment practices in Tourette syndrome: the European perspective.
Topics: Adult; Antidepressive Agents; Antipsychotic Agents; Anxiety; Aripiprazole; Atomoxetine Hydrochloride | 2012 |
A transgenic model of comorbid Tourette's syndrome and obsessive-compulsive disorder circuitry.
Topics: Analgesics; Animals; Cholera Toxin; Clonidine; Comorbidity; Female; Incidence; Male; Mice; Mice, Tra | 2002 |
Pediatric clonidine poisoning as a result of pharmacy compounding error.
Topics: Adrenergic alpha-Agonists; Attention Deficit Disorder with Hyperactivity; Child; Clonidine; Drug Com | 2002 |
A nine-year-old girl with new-onset tics.
Topics: Antipsychotic Agents; Child; Chorea; Clonidine; Diagnosis, Differential; Female; Humans; Obsessive-C | 2003 |
Trichotillomania and co-morbid psychiatric disorders in a 10-year-old boy.
Topics: Attention Deficit Disorder with Hyperactivity; Child; Clonidine; Comorbidity; Drug Therapy, Combinat | 2007 |
Tics, anxiety, and possible PANDAS in an adolescent.
Topics: Adolescent; Adrenergic alpha-Agonists; Antidepressive Agents, Second-Generation; Anxiety; Autoimmune | 2007 |
Biological markers in obsessive-compulsive and affective disorders.
Topics: Blood Platelets; Clomipramine; Clonidine; Depressive Disorder; Dexamethasone; Electroencephalography | 1984 |
Growth hormone response to clonidine in obsessive-compulsive patients.
Topics: Adolescent; Adult; Clonidine; Female; Growth Hormone; Humans; Male; Methoxyhydroxyphenylglycol; Midd | 1983 |
Successful treatment of obsessive-compulsive disorder with clonidine hydrochloride.
Topics: Adult; Clonidine; Drug Administration Schedule; Female; Humans; Obsessive-Compulsive Disorder | 1982 |
Side effects of clonidine.
Topics: Affective Disorders, Psychotic; Bipolar Disorder; Clonidine; Delusions; Humans; Obsessive-Compulsive | 1982 |
Noradrenergic receptor sensitivity in obsessive-compulsive disorders: I. Growth hormone response to clonidine stimulation.
Topics: Adolescent; Adrenergic alpha-Agonists; Adult; Clonidine; Female; Growth Hormone-Releasing Hormone; H | 1997 |
Noradrenergic receptor sensitivity in obsessive compulsive disorder: II. Cortisol response to acute clonidine administration.
Topics: Adolescent; Adrenergic alpha-Agonists; Adult; Clonidine; Female; Humans; Hydrocortisone; Male; Middl | 1997 |
Neurologic soft signs in obsessive-compulsive disorder.
Topics: Adult; Anxiety Disorders; Central Nervous System Diseases; Clomipramine; Clonidine; Depressive Disor | 1991 |
Alpha 2-adrenoreceptor status in obsessive-compulsive disorder.
Topics: Adult; Arousal; Blood Platelets; Brain; Clonidine; Female; Glycols; Growth Hormone; Humans; Male; Me | 1990 |
Biological alterations in the primary affective disorders and other tricyclic-responsive disorders.
Topics: Adult; Agoraphobia; Anorexia Nervosa; Clonidine; Cyclic AMP; Depressive Disorder; Dihydroergotoxine; | 1985 |
Tourette's syndrome in Monroe County school children.
Topics: Adolescent; Attention Deficit Disorder with Hyperactivity; Behavior; Child; Child, Preschool; Clonid | 1988 |
Clonidine and clomipramine in obsessive-compulsive disorder.
Topics: Adolescent; Adult; Clomipramine; Clonidine; Drug Therapy, Combination; Female; Humans; Male; Obsessi | 1987 |
A comparison between the growth hormone responses to amphetamine and clonidine.
Topics: Adult; Amphetamine; Clonidine; Depressive Disorder; Growth Hormone; Humans; Obsessive-Compulsive Dis | 1985 |