clonidine has been researched along with Obesity in 58 studies
Clonidine: An imidazoline sympatholytic agent that stimulates ALPHA-2 ADRENERGIC RECEPTORS and central IMIDAZOLINE RECEPTORS. It is commonly used in the management of HYPERTENSION.
clonidine (amino form) : A clonidine that is 4,5-dihydro-1H-imidazol-2-amine in which one of the amino hydrogens is replaced by a 2,6-dichlorophenyl group.
Obesity: A status with BODY WEIGHT that is grossly above the recommended standards, usually due to accumulation of excess FATS in the body. The standards may vary with age, sex, genetic or cultural background. In the BODY MASS INDEX, a BMI greater than 30.0 kg/m2 is considered obese, and a BMI greater than 40.0 kg/m2 is considered morbidly obese (MORBID OBESITY).
| Excerpt | Relevance | Reference |
|---|---|---|
| "The role of alpha 2-adrenoceptor stimulation by clonidine on the secretion of beta-endorphin, ACTH, and cortisol in essential hypertension and obesity was studied in 45 subjects: 15 non-obese hypertensives, 10 obese hypertensives, 11 obese normotensives, and 9 healthy subjects." | 9.06 | Effect of clonidine on beta-endorphin, ACTH and cortisol secretion in essential hypertension and obesity. ( Jeske, W; Puciłowska, J; Soszynski, P; Słowinska-Srzednicka, J; Wierzbicki, M; Zgliczynski, S, 1988) |
| "To assess growth hormone (GH) levels in response to acute clonidine stimulation in nonobese patients with polycystic ovary syndrome (PCOS) in comparison to patients with idiopathic hirsutism (IH) and normal women without hirsutism." | 7.72 | Increased growth hormone response to clonidine in nonobese normoinsulinemic patients with polycystic ovary syndrome. ( Comim, FV; Spritzer, PM, 2004) |
| "The role that the central sympathetic nervous system plays in the development of obesity hypertension and insulin was evaluated by feeding dogs a high fat diet with or without clonidine treatment." | 7.70 | Clonidine prevents insulin resistance and hypertension in obese dogs. ( Babu, K; Mao, HZ; Marker, P; Rocchini, AJ; Rocchini, AP, 1999) |
| "The decrease in arterial blood pressure in patients with essential arterial hypertension treated with clonidine is associated, in 88." | 7.68 | Effect of clonidine on serum inorganic phosphorus in patients with essential arterial hypertension. ( Uza, G, 1990) |
| "Obesity is associated with an impairment of the GH secretion elicited by all stimuli known to date, but the basic mechanism of this alteration is unknown." | 5.28 | Effect of central cholinergic neurotransmission enhancement by pyridostigmine on the growth hormone secretion elicited by clonidine, arginine, or hypoglycemia in normal and obese subjects. ( Casanueva, FF; Cordido, F; Dieguez, C, 1990) |
| "Clonidine induced an increase of more than 10 ng/ml in the plasma hGH levels in 10 (4 males, 6 females) of the 13 obese subjects and in all of the healthy controls, with peak levels ranging from 14." | 5.27 | Plasma growth hormone response to oral clonidine as compared to insulin hypoglycemia in obese children and adolescents. ( Bauman, B; Gil-Ad, I; Josefsberg, Z; Laron, Z; Topper, E, 1984) |
| "Obesity is characterized by an impairment of GH release in response to various stimuli." | 5.27 | Impaired growth hormone response to clonidine in obesity. ( Altomonte, L; Berchicci, M; Greco, AV; Mirone, L; Pellicano, P; Travaglini, R; Zoli, A, 1988) |
| "To clarify the possible neuroendocrine mechanisms underlying the impairment in growth hormone (GH) secretion present in obesity, the GH response to GH-releasing hormone (GHRH, N = 6), insulin hypoglycemia (N = 6), clonidine (N = 7) and arginine (N = 8) after GHRH pretreatment (1 microgram/kg iv 2 h before the tests) was evaluated in 27 obese peripubertal children and in a group of normal-weight short-normal children (N = 26)." | 5.08 | Growth hormone response to growth hormone-releasing hormone (GHRH), insulin, clonidine and arginine after GHRH pretreatment in obese children: evidence of somatostatin increase? ( Bernasconi, S; Costa, M; Cozzini, A; Ghizzoni, L; Iughetti, L; Rossi, M; Volta, C, 1995) |
| "The role of alpha 2-adrenoceptor stimulation by clonidine on the secretion of beta-endorphin, ACTH, and cortisol in essential hypertension and obesity was studied in 45 subjects: 15 non-obese hypertensives, 10 obese hypertensives, 11 obese normotensives, and 9 healthy subjects." | 5.06 | Effect of clonidine on beta-endorphin, ACTH and cortisol secretion in essential hypertension and obesity. ( Jeske, W; Puciłowska, J; Soszynski, P; Słowinska-Srzednicka, J; Wierzbicki, M; Zgliczynski, S, 1988) |
| "The I1-imidazoline receptor is a specific high-affinity binding site corresponding to a functional cell-surface receptor mediating the antihypertensive actions of moxonidine and other second-generation centrally-acting agents, and may play a role in countering insulin resistance in an animal model of metabolic syndrome X." | 4.79 | The I1-imidazoline receptor: from binding site to therapeutic target in cardiovascular disease. ( Ernsberger, P; Friedman, JE; Koletsky, RJ, 1997) |
| "To assess growth hormone (GH) levels in response to acute clonidine stimulation in nonobese patients with polycystic ovary syndrome (PCOS) in comparison to patients with idiopathic hirsutism (IH) and normal women without hirsutism." | 3.72 | Increased growth hormone response to clonidine in nonobese normoinsulinemic patients with polycystic ovary syndrome. ( Comim, FV; Spritzer, PM, 2004) |
| "The role that the central sympathetic nervous system plays in the development of obesity hypertension and insulin was evaluated by feeding dogs a high fat diet with or without clonidine treatment." | 3.70 | Clonidine prevents insulin resistance and hypertension in obese dogs. ( Babu, K; Mao, HZ; Marker, P; Rocchini, AJ; Rocchini, AP, 1999) |
| " To elucidate the relationship between VIP and the adrenergic system and its role in the mechanism of disturbed prolactin (PRL) and growth hormone (GH) release in obesity, serum VIP, GH, and PRL concentrations in response to alpha 2-adrenergic receptor agonist-clonidine were measured." | 3.68 | A marked decrease of vasoactive intestinal peptide release in obese patients. ( Baranowska, B, 1991) |
| "The decrease in arterial blood pressure in patients with essential arterial hypertension treated with clonidine is associated, in 88." | 3.68 | Effect of clonidine on serum inorganic phosphorus in patients with essential arterial hypertension. ( Uza, G, 1990) |
| " clonidine (an alpha 2-adrenergic agonist) were evaluated in 17 normal weight children (8 prepubertal and 9 pubertal) and in 15 children with simple exogenous obesity (7 prepubertal and 8 pubertal, weight excess ranging from 29% to 97%)." | 3.67 | Absent B-endorphin response to clonidine in obese children. ( Bernasconi, S; Facchinetti, F; Genazzani, AR; Iughetti, L; Marcellini, C; Petraglia, F, 1988) |
| " Similar responses were observed after oral dosing and in lean littermates." | 1.32 | The role of I(1)-imidazoline and alpha(2)-adrenergic receptors in the modulation of glucose metabolism in the spontaneously hypertensive obese rat model of metabolic syndrome X. ( Ernsberger, P; Velliquette, RA, 2003) |
| "Only clonidine treatment totally prevented the development of insulin resistance, and high-dose aspirin, known to prevent insulin resistance by inhibition of the activity of IkappaB kinase-beta, decreased the degree of insulin resistance by almost 70%." | 1.32 | Hypertension and insulin resistance are not directly related in obese dogs. ( Gokee, A; Rocchini, AP; Yang, JQ, 2004) |
| "LZR." | 1.32 | Enhanced arteriolar alpha-adrenergic constriction impairs dilator responses and skeletal muscle perfusion in obese Zucker rats. ( Frisbee, JC, 2004) |
| "Clonidine pretreatment similarly and significantly decreased NA levels in all women and, compared to the control test, marginally influenced the ACTH response to CRH + AVP." | 1.31 | alpha2-adrenoceptor regulation of the hypothalamic-pituitary-adrenocortical axis in obesity. ( Calzoni, F; Ceroni, L; Cortelli, P; Gambineri, A; Gnudi, U; Menozzi, R; Pasquali, R; Rio, GD; Sinisi, R; Vicennati, V, 2000) |
| "Glycerol release was measured and used as a lipolytic index." | 1.30 | Lipolytic catecholamine resistance linked to alpha 2-adrenoceptor sensitivity--a metabolic predictor of weight loss in obese subjects. ( Hagström-Toft, E; Hellström, L; Reynisdottir, S; Rössner, S, 1997) |
| "Pretreatment with Sumatriptan did not modify the GH response to clonidine or pyridostigmine, as assessed by the peak GH response and the area under the curve." | 1.29 | Role of the serotonin receptor subtype 5-HT1D on basal and stimulated growth hormone secretion. ( Bento, A; Dieguez, C; Mota, A; Peñalva, A; Pombo, M, 1995) |
| " Dose-response curves show similar sensitivity, but decreased responsiveness in the lean animal." | 1.28 | Food intake of lean and obese Zucker rats following ventricular infusions of adrenergic agonists. ( Bray, GA; Tsujii, S, 1992) |
| "This could participate in the hyperinsulinemia observed in these rats." | 1.28 | Increased islet blood flow in obese rats: role of the autonomic nervous system. ( Atef, N; Ktorza, A; Pénicaud, L; Picon, L, 1992) |
| "Obesity is associated with an impairment of the GH secretion elicited by all stimuli known to date, but the basic mechanism of this alteration is unknown." | 1.28 | Effect of central cholinergic neurotransmission enhancement by pyridostigmine on the growth hormone secretion elicited by clonidine, arginine, or hypoglycemia in normal and obese subjects. ( Casanueva, FF; Cordido, F; Dieguez, C, 1990) |
| "Clonidine induced an increase of more than 10 ng/ml in the plasma hGH levels in 10 (4 males, 6 females) of the 13 obese subjects and in all of the healthy controls, with peak levels ranging from 14." | 1.27 | Plasma growth hormone response to oral clonidine as compared to insulin hypoglycemia in obese children and adolescents. ( Bauman, B; Gil-Ad, I; Josefsberg, Z; Laron, Z; Topper, E, 1984) |
| " The dose-response relationships of the alpha 2- and beta-selective agents clonidine and isoproterenol were not appreciably changed by caloric restriction." | 1.27 | Adrenergic regulation of lipolysis in abdominal adipocytes of obese subjects during caloric restriction: reversal of catecholamine action caused by relief of endogenous inhibition. ( Fischer, B; Kather, H; Schlierf, G; Wieland, E; Wirth, A, 1985) |
| "Naloxone did not cause any significant change in beta-endorphin release." | 1.27 | The role of opiate, dopaminergic, and adrenergic systems in the hypothalamo-pituitary dysfunction in obesity. ( Baranowska, B; Jeske, W; Nowakowski, J; Singh, SP; Soszynski, P, 1987) |
| "Obesity is a circumstance characterized in the dog fat cell by a modification of the balance between alpha-2 and beta receptors." | 1.26 | Alpha-2 adrenergic antilipolytic effect in dog fat cells: incidence of obesity and adipose tissue localization. ( Berlan, M; Carpene, C; Dang-Tran, L; Lafontan, M, 1982) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 15 (25.86) | 18.7374 |
| 1990's | 31 (53.45) | 18.2507 |
| 2000's | 12 (20.69) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Eikelis, N | 1 |
| Schlaich, M | 1 |
| Aggarwal, A | 1 |
| Kaye, D | 1 |
| Esler, M | 1 |
| Velliquette, RA | 1 |
| Ernsberger, P | 2 |
| Comim, FV | 1 |
| Spritzer, PM | 1 |
| Rocchini, AP | 2 |
| Yang, JQ | 1 |
| Gokee, A | 1 |
| Frisbee, JC | 1 |
| Amador, N | 1 |
| Pérez-Luque, E | 1 |
| Malacara, JM | 1 |
| Guízar, JM | 1 |
| Paniagua, R | 1 |
| Lara, S | 1 |
| Levin, BE | 5 |
| Hamm, MW | 1 |
| Berlan, M | 1 |
| Carpene, C | 1 |
| Lafontan, M | 1 |
| Dang-Tran, L | 1 |
| Topper, E | 1 |
| Gil-Ad, I | 1 |
| Bauman, B | 1 |
| Josefsberg, Z | 1 |
| Laron, Z | 1 |
| Kemnitz, JW | 1 |
| Rozen, R | 1 |
| Banegas, E | 1 |
| Davilla, M | 1 |
| Apfelbaum, M | 1 |
| Atef, N | 2 |
| Ktorza, A | 2 |
| Pénicaud, L | 2 |
| Mota, A | 1 |
| Bento, A | 1 |
| Peñalva, A | 1 |
| Pombo, M | 1 |
| Dieguez, C | 2 |
| Volta, C | 1 |
| Bernasconi, S | 2 |
| Iughetti, L | 2 |
| Ghizzoni, L | 1 |
| Rossi, M | 1 |
| Costa, M | 1 |
| Cozzini, A | 1 |
| Baranowska, B | 4 |
| Wasilewska-Dziubińska, E | 2 |
| Radzikowska, M | 2 |
| Płonowski, A | 1 |
| Roguski, K | 2 |
| Planas, B | 1 |
| Reynisdottir, S | 3 |
| Ellerfeldt, K | 1 |
| Wahrenberg, H | 1 |
| Lithell, H | 1 |
| Arner, P | 2 |
| Miralles, A | 1 |
| Ribas, C | 1 |
| Olmos, G | 1 |
| García-Sevilla, JA | 1 |
| Currie, PJ | 3 |
| Del Rio, G | 1 |
| Zizzo, G | 1 |
| Bonati, ME | 1 |
| Macdonald, IA | 1 |
| Velardo, A | 1 |
| Hellström, L | 2 |
| Langin, D | 1 |
| Dauzats, M | 1 |
| Friedman, JE | 1 |
| Koletsky, RJ | 1 |
| Rössner, S | 1 |
| Hagström-Toft, E | 1 |
| Mao, HZ | 1 |
| Babu, K | 1 |
| Marker, P | 1 |
| Rocchini, AJ | 1 |
| Pasquali, R | 1 |
| Vicennati, V | 1 |
| Calzoni, F | 1 |
| Gnudi, U | 1 |
| Gambineri, A | 1 |
| Ceroni, L | 1 |
| Cortelli, P | 1 |
| Menozzi, R | 1 |
| Sinisi, R | 1 |
| Rio, GD | 1 |
| Corrias, A | 1 |
| Bellone, J | 1 |
| Beccaria, L | 1 |
| Bosio, L | 1 |
| Trifirò, G | 1 |
| Livieri, C | 1 |
| Ragusa, L | 1 |
| Salvatoni, A | 1 |
| Andreo, M | 1 |
| Ciampalini, P | 1 |
| Tonini, G | 1 |
| Crinò, A | 1 |
| Boundy, VA | 1 |
| Cincotta, AH | 1 |
| Borowiec, M | 1 |
| Malara, A | 1 |
| Corsonello, A | 1 |
| Buemi, M | 1 |
| De Domenico, D | 1 |
| Ientile, R | 1 |
| Corica, F | 1 |
| Pelat, M | 1 |
| Verwaerde, P | 1 |
| Tran, MA | 1 |
| Montastruc, JL | 1 |
| Senard, JM | 1 |
| Reisin, E | 1 |
| Weed, SG | 1 |
| Chan, CB | 1 |
| MacPhail, RM | 1 |
| Tsujii, S | 1 |
| Bray, GA | 1 |
| Wilson, LM | 2 |
| Picon, L | 1 |
| Jhanwar-Uniyal, M | 1 |
| Awad, IR | 1 |
| Gearhart, GM | 1 |
| Finkelstein, JA | 1 |
| Leibowitz, SF | 1 |
| Mauriège, P | 1 |
| Després, JP | 1 |
| Prud'homme, D | 1 |
| Pouliot, MC | 1 |
| Marcotte, M | 1 |
| Tremblay, A | 1 |
| Bouchard, C | 1 |
| Singh, SK | 1 |
| Agrawal, JK | 1 |
| Rai, M | 1 |
| Gupta, SS | 1 |
| Koulu, M | 1 |
| Huupponen, R | 1 |
| Hänninen, H | 1 |
| Pesonen, U | 1 |
| Rouru, J | 1 |
| Seppälä, T | 1 |
| Uza, G | 1 |
| Presta, E | 1 |
| Leibel, RL | 1 |
| Hirsch, J | 1 |
| Cordido, F | 1 |
| Casanueva, FF | 1 |
| Satta, MA | 1 |
| Castelli, A | 1 |
| Maussier, ML | 1 |
| Scoppola, A | 1 |
| Valenza, V | 1 |
| Saletnich, I | 1 |
| Monaco, F | 1 |
| Roche, J | 1 |
| Auclair, MC | 1 |
| Vernimmen, C | 1 |
| Lavau, M | 1 |
| Lechat, P | 1 |
| Słowinska-Srzednicka, J | 2 |
| Zgliczynski, S | 2 |
| Soszynski, P | 3 |
| Puciłowska, J | 1 |
| Wierzbicki, M | 2 |
| Jeske, W | 3 |
| Kather, H | 2 |
| Wieland, E | 1 |
| Fischer, B | 1 |
| Wirth, A | 1 |
| Schlierf, G | 2 |
| Singh, SP | 1 |
| Nowakowski, J | 1 |
| Facchinetti, F | 1 |
| Petraglia, F | 1 |
| Marcellini, C | 1 |
| Genazzani, AR | 1 |
| Altomonte, L | 1 |
| Zoli, A | 1 |
| Mirone, L | 1 |
| Berchicci, M | 1 |
| Travaglini, R | 1 |
| Pellicano, P | 1 |
| Greco, AV | 1 |
| Scheurer, A | 1 |
| Richelsen, B | 1 |
| Linquette, M | 1 |
| Fossati, P | 1 |
| Fourlinnie, JC | 1 |
| Voimant, YM | 1 |
2 reviews available for clonidine and Obesity
| Article | Year |
|---|---|
Obesity in macaques: spontaneous and induced.
Topics: Age Factors; Animals; Animals, Laboratory; Body Weight; Clonidine; Enteral Nutrition; Female; Humans | 1984 |
The I1-imidazoline receptor: from binding site to therapeutic target in cardiovascular disease.
Topics: Animals; Antihypertensive Agents; Binding Sites; Clonidine; Humans; Hypertension; Imidazoles; Imidaz | 1997 |
7 trials available for clonidine and Obesity
| Article | Year |
|---|---|
Interactions between leptin and the human sympathetic nervous system.
Topics: Adult; Aging; Antihypertensive Agents; Autonomic Nervous System Diseases; Clonidine; Epinephrine; Fe | 2003 |
Leptin and heart sympathetic activity in normotensive obese and non-obese subjects.
Topics: Adipose Tissue; Adrenergic alpha-Agonists; Adult; Angiotensin-Converting Enzyme Inhibitors; Antihype | 2004 |
Growth hormone response to growth hormone-releasing hormone (GHRH), insulin, clonidine and arginine after GHRH pretreatment in obese children: evidence of somatostatin increase?
Topics: Adolescent; Arginine; Child; Clonidine; Female; Growth Hormone; Growth Hormone-Releasing Hormone; Hu | 1995 |
GH/IGF-I axis in Prader-Willi syndrome: evaluation of IGF-I levels and of the somatotroph responsiveness to various provocative stimuli. Genetic Obesity Study Group of Italian Society of Pediatric Endocrinology and Diabetology.
Topics: Adolescent; Adrenergic alpha-Agonists; Adult; Arginine; Child; Child, Preschool; Clonidine; Female; | 2000 |
The treatment of obese hypertensive black women: a comparative study of chlorthalidone versus clonidine.
Topics: Black People; Blood Pressure; Chlorthalidone; Clonidine; Double-Blind Method; Drug Therapy, Combinat | 1992 |
Effect of clonidine on beta-endorphin, ACTH and cortisol secretion in essential hypertension and obesity.
Topics: Adrenocorticotropic Hormone; Adult; beta-Endorphin; Circadian Rhythm; Clonidine; Female; Humans; Hyd | 1988 |
Growth hormone (GH) secretion during nocturnal sleep and after clonidine in patients with essential hypertension.
Topics: Adolescent; Adult; Blood Pressure; Body Weight; Clonidine; Female; Growth Hormone; Humans; Hypertens | 1988 |
49 other studies available for clonidine and Obesity
| Article | Year |
|---|---|
The role of I(1)-imidazoline and alpha(2)-adrenergic receptors in the modulation of glucose metabolism in the spontaneously hypertensive obese rat model of metabolic syndrome X.
Topics: Adrenergic alpha-2 Receptor Antagonists; Animals; Clonidine; Disease Models, Animal; Female; Glucose | 2003 |
Increased growth hormone response to clonidine in nonobese normoinsulinemic patients with polycystic ovary syndrome.
Topics: Adolescent; Adult; Body Weight; Case-Control Studies; Clonidine; Cross-Sectional Studies; Female; Hi | 2004 |
Hypertension and insulin resistance are not directly related in obese dogs.
Topics: Adrenergic beta-Antagonists; Animals; Aspirin; Atenolol; Blood Glucose; Clonidine; Diet, Sodium-Rest | 2004 |
Enhanced arteriolar alpha-adrenergic constriction impairs dilator responses and skeletal muscle perfusion in obese Zucker rats.
Topics: Adrenergic alpha-Agonists; Animals; Arterioles; Clonidine; Male; Metabolic Syndrome; Muscle, Skeleta | 2004 |
Plasticity of brain alpha-adrenoceptors during the development of diet-induced obesity in the rat.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Brain; Clonidine; Fatty Acids; Mal | 1994 |
Alpha-2 adrenergic antilipolytic effect in dog fat cells: incidence of obesity and adipose tissue localization.
Topics: Adipose Tissue; Animals; Clonidine; Dogs; Epinephrine; Isoproterenol; Lipolysis; Obesity; Prazosin; | 1982 |
Plasma growth hormone response to oral clonidine as compared to insulin hypoglycemia in obese children and adolescents.
Topics: Adolescent; Child; Child, Preschool; Clonidine; Female; Growth Hormone; Humans; Hypoglycemia; Insuli | 1984 |
Effects of a very-low-calorie diet on adrenergic responsiveness in human adipose tissue.
Topics: Adipose Tissue; Adult; Clonidine; Diet, Reducing; Female; Humans; Isoproterenol; Lipolysis; Middle A | 1984 |
CNS involvement in the glucose induced increase of islet blood flow in obese Zucker rats.
Topics: Animals; Blood Flow Velocity; Brain; Carotid Arteries; Clonidine; Female; Glucose; Injections, Intra | 1995 |
Role of the serotonin receptor subtype 5-HT1D on basal and stimulated growth hormone secretion.
Topics: Arginine; Child; Clonidine; Female; Follicle Stimulating Hormone; Gonadotropin-Releasing Hormone; Gr | 1995 |
Impaired response of atrial natriuretic peptide to acute water load in obesity and in anorexia nervosa.
Topics: Adolescent; Adult; Anorexia Nervosa; Atrial Natriuretic Factor; Body Weight; Clonidine; Female; Huma | 1995 |
Defective glucoregulation of brain alpha 2-adrenoceptors in obesity-prone rats.
Topics: Adrenergic alpha-Agonists; Animals; Blood Glucose; Brain; Clonidine; Diet; Disease Susceptibility; M | 1993 |
Multiple lipolysis defects in the insulin resistance (metabolic) syndrome.
Topics: Adipose Tissue; Aged; Clonidine; Dose-Response Relationship, Drug; Humans; Insulin Resistance; Isopr | 1994 |
No effect of genetic obesity and mazindol on imidazoline I2 binding sites in the brain of Zucker rats.
Topics: Animals; Binding Sites; Brain Chemistry; Clonidine; Dioxanes; Idazoxan; Imidazoline Receptors; Male; | 1993 |
Differential effects of NE, CLON, and 5-HT on feeding and macronutrient selection in genetically obese (ob/ob) and lean mice.
Topics: Animals; Clonidine; Energy Metabolism; Feeding Behavior; Food Preferences; Male; Mice; Mice, Inbred | 1993 |
Cardiovascular and catecholamine response to clonidine in obese subjects.
Topics: Adrenergic alpha-Agonists; Adult; Blood Pressure; Cardiovascular Physiological Phenomena; Cardiovasc | 1995 |
Reduced paraventricular nucleus norepinephrine responsiveness in obesity-prone rats.
Topics: Adrenergic alpha-Agonists; Amygdala; Animals; Clonidine; Diet; Disease Susceptibility; Hypothalamus; | 1996 |
Adipocyte lipolysis in normal weight subjects with obesity among first-degree relatives.
Topics: Adipocytes; Adrenergic beta-Agonists; Adult; Body Mass Index; Bucladesine; Clonidine; Colforsin; Dia | 1996 |
Lipolytic catecholamine resistance linked to alpha 2-adrenoceptor sensitivity--a metabolic predictor of weight loss in obese subjects.
Topics: Adenosine Deaminase; Adipose Tissue; Adrenergic alpha-Agonists; Adrenergic beta-Agonists; Adult; Bio | 1997 |
Clonidine prevents insulin resistance and hypertension in obese dogs.
Topics: Animals; Antihypertensive Agents; Blood Glucose; Blood Pressure; Body Weight; Cardiac Output; Clonid | 1999 |
alpha2-adrenoceptor regulation of the hypothalamic-pituitary-adrenocortical axis in obesity.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Adrenocorticotropic Hormone; Adult; Arginin | 2000 |
Hypothalamic adrenergic receptor changes in the metabolic syndrome of genetically obese (ob/ob) mice.
Topics: Animals; Autoradiography; Clonidine; Female; Hypothalamus; In Vitro Techniques; Iodocyanopindolol; M | 2000 |
The role of VIP and somatostatin in the control of GH and prolactin release in anorexia nervosa and in obesity.
Topics: Adolescent; Adult; Anorexia Nervosa; Case-Control Studies; Clonidine; Female; Gonadotropin-Releasing | 2000 |
Effects of alpha- and beta-adrenergic stimulation on free magnesium concentrations in platelets from healthy and obese individuals.
Topics: Adrenergic alpha-Agonists; Adrenergic beta-Agonists; Adult; Blood Platelets; Clonidine; Epinephrine; | 2001 |
Alpha2 -adrenoceptor function in arterial hypertension associated with obesity in dogs fed a high-fat diet.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Animals; Blood | 2002 |
Functional characterization of alpha-adrenoceptors on pancreatic islets of fa/fa Zucker rats.
Topics: Animals; Cells, Cultured; Clonidine; Colforsin; Cyclic AMP; Dose-Response Relationship, Drug; Epinep | 1992 |
Food intake of lean and obese Zucker rats following ventricular infusions of adrenergic agonists.
Topics: Adrenergic beta-Agonists; Albuterol; Animals; Clonidine; Dose-Response Relationship, Drug; Drug Inte | 1992 |
Yohimbine attenuates clonidine-induced feeding and macronutrient selection in genetically obese (ob/ob) mice.
Topics: Animals; Clonidine; Diet; Dietary Carbohydrates; Energy Intake; Feeding Behavior; Food Preferences; | 1992 |
Increased islet blood flow in obese rats: role of the autonomic nervous system.
Topics: Animals; Autonomic Nervous System; Clonidine; Female; Glucose; Hyperinsulinism; Hypothalamus; Inject | 1992 |
Higher alpha-noradrenergic receptors in paraventricular nucleus of obese Zucker rats: decline after food deprivation.
Topics: Adrenergic alpha-Agonists; Animals; Clonidine; Female; Food Deprivation; Norepinephrine; Obesity; Pa | 1991 |
Regional variation in adipose tissue lipolysis in lean and obese men.
Topics: Adipose Tissue; Adult; Body Composition; Clonidine; Epinephrine; Humans; Isoproterenol; Lipolysis; M | 1991 |
Growth hormone response to clonidine in obese children.
Topics: Adolescent; Child; Clonidine; Exercise Test; Female; Growth Hormone; Humans; Male; Obesity | 1991 |
A marked decrease of vasoactive intestinal peptide release in obese patients.
Topics: Adult; Clonidine; Growth Hormone; Humans; Middle Aged; Obesity; Prolactin; Receptors, Adrenergic, al | 1991 |
Increased brain 3H-paraminoclonidine (alpha 2-adrenoceptor) binding associated with perpetuation of diet-induced obesity in rats.
Topics: Adrenergic alpha-Agonists; Animals; Brain; Clonidine; Diet; Male; Models, Biological; Obesity; Rats; | 1990 |
Hypothalamic neurochemistry and feeding behavioral responses to clonidine, an alpha-2-agonist, and to trifluoromethylphenylpiperazine, a putative 5-hydroxytryptamine-1B agonist, in genetically obese Zucker rats.
Topics: 5-Hydroxytryptophan; Adrenergic alpha-Agonists; Animals; Aromatic Amino Acid Decarboxylase Inhibitor | 1990 |
Bidirectional effects of clonidine on carbohydrate intake in genetically obese (ob/ob) mice.
Topics: Animals; Body Weight; Clonidine; Diet; Dietary Carbohydrates; Dietary Fats; Dietary Proteins; Energy | 1991 |
Effect of clonidine on serum inorganic phosphorus in patients with essential arterial hypertension.
Topics: Blood Pressure; Clonidine; Female; Growth Hormone; Humans; Hypertension; Insulin; Male; Middle Aged; | 1990 |
Regional changes in adrenergic receptor status during hypocaloric intake do not predict changes in adipocyte size or body shape.
Topics: Abdomen; Adipose Tissue; Adult; Anthropometry; Biopsy, Needle; Body Mass Index; Buttocks; Clonidine; | 1990 |
Effect of central cholinergic neurotransmission enhancement by pyridostigmine on the growth hormone secretion elicited by clonidine, arginine, or hypoglycemia in normal and obese subjects.
Topics: Adolescent; Adult; Arginine; Child; Cholinergic Fibers; Clonidine; Drug Interactions; Female; Growth | 1990 |
Obesity-prone and -resistant rats differ in their brain [3H]paraminoclonidine binding.
Topics: Animals; Brain; Clonidine; Male; Obesity; Prazosin; Rats; Rats, Inbred Strains; Receptors, Adrenergi | 1990 |
[Naloxone doesn't determine the response of growth hormone to clonidine in obese patients].
Topics: Adolescent; Adult; Clonidine; Female; Growth Hormone; Humans; Male; Naloxone; Obesity | 1989 |
Dependence on extracellular potassium of the positive inotropic response to St 587, a selective alpha-1 adrenoceptor agonist, in Zucker rat heart ventricle.
Topics: Action Potentials; Adrenergic alpha-Agonists; Animals; Cell Membrane; Clonidine; Heart Ventricles; M | 1989 |
Adrenergic regulation of lipolysis in abdominal adipocytes of obese subjects during caloric restriction: reversal of catecholamine action caused by relief of endogenous inhibition.
Topics: Adenosine; Adipose Tissue; Adolescent; Adrenergic Agonists; Adult; Aged; Catecholamines; Cells, Cult | 1985 |
The role of opiate, dopaminergic, and adrenergic systems in the hypothalamo-pituitary dysfunction in obesity.
Topics: Adolescent; Adrenergic alpha-Agonists; Adult; beta-Endorphin; Clonidine; Female; Growth Hormone; Hum | 1987 |
Absent B-endorphin response to clonidine in obese children.
Topics: beta-Endorphin; Child; Clonidine; Female; Growth Hormone; Humans; Hydrocortisone; Male; Obesity | 1988 |
Impaired growth hormone response to clonidine in obesity.
Topics: Administration, Oral; Adult; Clonidine; Female; Growth Hormone; Humans; Male; Obesity | 1988 |
Antilipolytic action of insulin in abdominal adipocytes of obese subjects before and during energy restriction. Influence of adenosine deaminase.
Topics: Abdomen; Adenosine Deaminase; Adipose Tissue; Adult; Clonidine; Dinoprostone; Dose-Response Relation | 1987 |
Prostaglandin E2 action and binding in human adipocytes: effects of sex, age, and obesity.
Topics: Adenosine Deaminase; Adipose Tissue; Adolescent; Adult; Age Factors; Aged; Clonidine; Dinoprostone; | 1988 |
[Catapressan in diabetics and the hypertensive obese. Study of glucose regulation].
Topics: Adult; Blood Glucose; Carbohydrate Metabolism; Clonidine; Diabetes Complications; Female; Humans; Hy | 1973 |