clonidine has been researched along with Neuroblastoma in 19 studies
Clonidine: An imidazoline sympatholytic agent that stimulates ALPHA-2 ADRENERGIC RECEPTORS and central IMIDAZOLINE RECEPTORS. It is commonly used in the management of HYPERTENSION.
clonidine (amino form) : A clonidine that is 4,5-dihydro-1H-imidazol-2-amine in which one of the amino hydrogens is replaced by a 2,6-dichlorophenyl group.
Neuroblastoma: A common neoplasm of early childhood arising from neural crest cells in the sympathetic nervous system, and characterized by diverse clinical behavior, ranging from spontaneous remission to rapid metastatic progression and death. This tumor is the most common intraabdominal malignancy of childhood, but it may also arise from thorax, neck, or rarely occur in the central nervous system. Histologic features include uniform round cells with hyperchromatic nuclei arranged in nests and separated by fibrovascular septa. Neuroblastomas may be associated with the opsoclonus-myoclonus syndrome. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, pp2099-2101; Curr Opin Oncol 1998 Jan;10(1):43-51)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Clonidine was a partial agonist." | 1.30 | Functional alpha2C-adrenoceptors in human neuroblastoma SH-SY5Y cells. ( Bobirnac, I; Gazi, L; Loetscher, E; Parsley, S; Schoeffter, P, 1999) |
| "The paroxysmal hypertension is believed to have resulted from the synergistic effect of the high levels of circulating catecholamines from the tumor and the disruption of autonomic pathways." | 1.27 | Autonomic dysreflexia in a paraplegic man with catecholamine-secreting neuroblastoma. ( Agre, JC; Theologides, A; Wilson, BC; Wright, KC, 1986) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 12 (63.16) | 18.7374 |
| 1990's | 5 (26.32) | 18.2507 |
| 2000's | 1 (5.26) | 29.6817 |
| 2010's | 1 (5.26) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Xie, SS | 1 |
| Wang, X | 1 |
| Jiang, N | 1 |
| Yu, W | 1 |
| Wang, KD | 1 |
| Lan, JS | 1 |
| Li, ZR | 1 |
| Kong, LY | 1 |
| Mollereau, C | 1 |
| Zajac, JM | 1 |
| Roumy, M | 1 |
| Plishka, RJ | 1 |
| Neale, JH | 1 |
| Dawson, G | 4 |
| Berry-Kravis, E | 3 |
| Louie, AK | 1 |
| Atlas, D | 2 |
| Sabol, SL | 2 |
| U'Prichard, DC | 1 |
| Freedman, SB | 1 |
| Ammer, H | 1 |
| Schulz, R | 1 |
| Parsley, S | 1 |
| Gazi, L | 1 |
| Bobirnac, I | 1 |
| Loetscher, E | 1 |
| Schoeffter, P | 1 |
| Greney, H | 1 |
| Heemskerk, F | 1 |
| Vonthron, C | 1 |
| Magnier, C | 1 |
| Bousquet, P | 1 |
| Dontenwill, M | 1 |
| Dalman, HM | 1 |
| Neubig, RR | 1 |
| Gleason, MM | 1 |
| Hieble, JP | 1 |
| Kazmi, SM | 1 |
| Mishra, RK | 1 |
| Ernsberger, P | 1 |
| Meeley, MP | 1 |
| Reis, DJ | 1 |
| Zhu, XZ | 1 |
| Chuang, DM | 1 |
| Wright, KC | 1 |
| Agre, JC | 1 |
| Wilson, BC | 1 |
| Theologides, A | 1 |
19 other studies available for clonidine and Neuroblastoma
| Article | Year |
|---|---|
Multi-target tacrine-coumarin hybrids: cholinesterase and monoamine oxidase B inhibition properties against Alzheimer's disease.
Topics: Acetylcholinesterase; Alzheimer Disease; Benzopyrans; Blood-Brain Barrier; Brain; Cell Survival; Cel | 2015 |
Staurosporine differentiation of NPFF2 receptor-transfected SH-SY5Y neuroblastoma cells induces selectivity of NPFF activity towards opioid receptors.
Topics: Calcium; Cell Differentiation; Cell Line, Tumor; Cell Membrane; Clonidine; Enkephalin, Ala(2)-MePhe( | 2007 |
Morphine treatment increases clonidine binding in brain cell cultures.
Topics: Animals; Brain; Cell Line; Cells, Cultured; Clonidine; Glioma; Mice; Mice, Inbred C57BL; Mice, Inbre | 1984 |
Gangliosides as modulators of the coupling of neurotransmitters to adenylate cyclase.
Topics: Adenylyl Cyclases; Animals; Brain; Cell Line; Clonidine; Cricetinae; Cricetulus; Enkephalin, Leucine | 1984 |
Effects of opiate and alpha 2-adrenergic agonists in a neuroblastoma x brain explant hybrid cell line (NCB-20).
Topics: Adrenergic alpha-Agonists; Alprostadil; Animals; Brain; Cell Line; Clonidine; Cricetinae; Cricetulus | 1984 |
A novel analogue of clonidine with opiate-receptor agonist activity.
Topics: Adenylyl Cyclases; Animals; Binding, Competitive; Brain; Clonidine; Glioma; Hybrid Cells; Kinetics; | 1980 |
Interaction of clonidine and clonidine analogues with alpha-adrenergic receptors of neuroblastoma X glioma hybrid cells and rat brain: comparison of ligand binding with inhibition of adenylate cyclase.
Topics: Adenylyl Cyclase Inhibitors; Animals; Benzeneacetamides; Brain; Clonidine; Female; Glioma; Hybrid Ce | 1981 |
3H-clonidine and 3H-p-aminoclonidine interactions in vitro with central and peripheral alpha 2-adrenergic receptors.
Topics: Adenylyl Cyclases; Animals; Binding, Competitive; Blood Platelets; Brain; Cattle; Cell Line; Cell Me | 1981 |
Specific receptor-mediated inhibition of cyclic AMP synthesis by dopamine in a neuroblastoma X brain hybrid cell line NCB-20.
Topics: Alprostadil; Animals; Apomorphine; Brain; Cell Line; Cell Membrane; Clonidine; Cricetinae; Cricetulu | 1984 |
Chronic exposure of NG 108-15 cells to inhibitory acting drugs reduces stimulatory prostaglandin E1 receptor number.
Topics: Adenylate Cyclase Toxin; Adenylyl Cyclases; Adrenergic alpha-Agonists; Alprostadil; Animals; Binding | 1996 |
Functional alpha2C-adrenoceptors in human neuroblastoma SH-SY5Y cells.
Topics: Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Br | 1999 |
Coexpression of imidazoline receptors and alpha 2-adrenoceptors in neuroglial cell line NG 108,15.
Topics: Animals; Binding, Competitive; Cell Membrane; Clonidine; Glioma; Hybrid Cells; Idazoxan; Imidazoline | 1999 |
Two peptides from the alpha 2A-adrenergic receptor alter receptor G protein coupling by distinct mechanisms.
Topics: Amino Acid Sequence; Animals; Binding, Competitive; Blood Platelets; Cell Line; Cell Membrane; Cloni | 1991 |
Ability of SK&F 104078 and SK&F 104856 to identify alpha-2 adrenoceptor subtypes in NCB20 cells and guinea pig lung.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Benzazepines; Brimonidine Tartrate | 1991 |
Identification of alpha 2-adrenergic receptor sites in human retinoblastoma (Y-79) and neuroblastoma (SH-SY5Y) cells.
Topics: Binding, Competitive; Cell Membrane; Clonidine; Epinephrine; Guanylyl Imidodiphosphate; Humans; Neur | 1989 |
Neuroblastoma-glioma hybrid cells contain clonidine-displacing substance.
Topics: Animals; Brain; Clonidine; Gastric Fundus; Glioma; Hybrid Cells; Mice; Muscle, Smooth; Neuroblastoma | 1989 |
Differential regulation by butyrate and dibutyryl cyclic AMP of delta-opioid, alpha 2-adrenergic, and muscarinic cholinergic receptors in NCB-20 cells.
Topics: Alprostadil; Animals; Binding, Competitive; Brain; Bucladesine; Butyrates; Butyric Acid; Carbachol; | 1988 |
Evidence for [D-Ala2,D-Leu5]enkephalin-induced supersensitivity to 5-hydroxytryptamine in a neurotumor x brain hybrid cell line (NCB-20).
Topics: Adenylyl Cyclases; Alprostadil; Animals; Brain; Brain Chemistry; Cell Line; Cholera Toxin; Clonidine | 1985 |
Autonomic dysreflexia in a paraplegic man with catecholamine-secreting neuroblastoma.
Topics: Adult; Autonomic Nervous System Diseases; Catecholamines; Clonidine; Humans; Hypertension; Male; Neu | 1986 |