Page last updated: 2024-10-25

clonidine and Nervous System Disorders

clonidine has been researched along with Nervous System Disorders in 10 studies

Clonidine: An imidazoline sympatholytic agent that stimulates ALPHA-2 ADRENERGIC RECEPTORS and central IMIDAZOLINE RECEPTORS. It is commonly used in the management of HYPERTENSION.
clonidine (amino form) : A clonidine that is 4,5-dihydro-1H-imidazol-2-amine in which one of the amino hydrogens is replaced by a 2,6-dichlorophenyl group.

Research Excerpts

ExcerptRelevanceReference
" Narcotics are used for the euphoria they provide; however, chronic use results in physiological and psychological changes."2.37Narcotic withdrawal in the emergency department. ( Freitas, PM, 1985)

Research

Studies (10)

TimeframeStudies, this research(%)All Research%
pre-19905 (50.00)18.7374
1990's2 (20.00)18.2507
2000's1 (10.00)29.6817
2010's2 (20.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Kubo, Y1
Dworkin, RH1
Treggiari, MM1
Romand, JA1
Martin, JB1
Reverdin, A1
Rüfenacht, DA1
de Tribolet, N1
Coombs, DW1
Goldberg-Stern, H1
Atlas, D1
Schwartz, L1
Achiron, A1
Ziv, I1
Djaldetti, R1
Zoldan, Y1
Melamed, E1
Metz, SA1
Halter, JB1
Porte, D1
Robertson, RP1
Moreau, R1
Caine, ED1
McBride, MC1
Chiverton, P1
Bamford, KA1
Rediess, S1
Shiao, J1
Sandyk, R1
Gillman, MA1
Iacono, RP1
Bamford, CR1
Freitas, PM1

Clinical Trials (2)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Cervical Sympathetic Block to Increase Cerebral Blood Flow in Patients With Cerebral Vasospasm Following Aneurysmal Subarachnoid Hemorrhage[NCT05230134]10 participants (Anticipated)Interventional2023-07-27Enrolling by invitation
Stellate Ganglion Block for the Treatment of COVID-19-Induced Olfactory Dysfunction: A Prospective Pilot Study[NCT05445921]Phase 1/Phase 220 participants (Actual)Interventional2022-09-01Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Olfactory Dysfunction Outcomes Rating (ODOR)

"Participants will be asked to complete the ODOR, which is a patient-reported outcome measure assessing physical problems, functional limitations, and emotional consequences of olfactory dysfunction.~The ODOR has a minimum score of 0 and a maximum score of 112 with higher scores indicating a greater degree of impairment and limitation. The minimal clinically important difference is a change of 15 points." (NCT05445921)
Timeframe: baseline, 5-10 days post SGB #1, and 1 month

Interventionscore on a scale (Median)
ODOR at BaselineODOR at 1 WeekODOR at 1 Month
Stellate Ganglion Block625750.5

University of Pennsylvania Smell Identification Test (UPSIT)

"Participants will complete the 40-item scratch and sniff UPSIT and mean change will be assessed.~The UPSIT has a minimum score of 0 and maximum score of 40 with lower scores indicating a greater degree of impairment. An UPSIT score of >33 for men and >34 for women is considered normosmic, and the minimal clinically important difference is a change of 4 points." (NCT05445921)
Timeframe: baseline, 5-10 days, and 1 month

Interventionunits on a scale (Median)
UPSIT at BaselineUPSIT at 1 WeekUPSIT at 1 Month
Stellate Ganglion Block16.52122.5

Clinical Global Impression - Improvement (CGI-I) Score

Participants will be asked about their change in olfactory dysfunction on a 7-point Likert scale from much better to much worse. (NCT05445921)
Timeframe: 5-10 days post SGB #1 and 1 month

InterventionParticipants (Count of Participants)
CGI-I for Smell Loss at 1 Week71922197CGI-I for Smell Loss at 1 Month71922197CGI-I for Smell Distortion at 1 Week71922197CGI-I for Smell Distortion at 1 Month71922197CGI-I for Taste Loss at 1 Week71922197CGI-I for Taste Loss at 1 Month71922197CGI-I for Taste Distortion at 1 Week71922197CGI-I for Taste Distortion at 1 Month71922197
About the SameSlightly BetterMuch BetterModerately Better
Stellate Ganglion Block8
Stellate Ganglion Block10
Stellate Ganglion Block9
Stellate Ganglion Block11
Stellate Ganglion Block6
Stellate Ganglion Block1
Stellate Ganglion Block15
Stellate Ganglion Block4
Stellate Ganglion Block0
Stellate Ganglion Block14
Stellate Ganglion Block3
Stellate Ganglion Block2
Stellate Ganglion Block13
Stellate Ganglion Block12
Stellate Ganglion Block5

Clinical Global Impression - Severity (CGI-S) Score

Participants will be asked about the severity of their olfactory dysfunction (and gustatory dysfunction) on a 5-point Likert scale from no smell loss to severe smell loss. (NCT05445921)
Timeframe: baseline, 5-10 days, and 1 month

InterventionParticipants (Count of Participants)
CGI-S for Smell Loss at Baseline71922197CGI-S for Smell Loss at 1 Week71922197CGI-S for Smell Loss at 1 Month71922197CGI-S for Smell Distortion at Baseline71922197CGI-S for Smell Distortion at 1 Week71922197CGI-S for Smell Distortion at 1 Month71922197CGI-S for Taste Loss at Baseline71922197CGI-S for Taste Loss at 1 Week71922197CGI-S for Taste Loss at 1 Month71922197CGI-S for Taste Distortion at Baseline71922197CGI-S for Taste Distortion at 1 Week71922197CGI-S for Taste Distortion at 1 Month71922197
No ProblemVery Mild ProblemMild ProblemModerate ProblemSevere Problem
Stellate Ganglion Block0
Stellate Ganglion Block3
Stellate Ganglion Block2
Stellate Ganglion Block8
Stellate Ganglion Block7
Stellate Ganglion Block9
Stellate Ganglion Block1
Stellate Ganglion Block5
Stellate Ganglion Block12
Stellate Ganglion Block4
Stellate Ganglion Block10
Stellate Ganglion Block11
Stellate Ganglion Block6

Reviews

4 reviews available for clonidine and Nervous System Disorders

ArticleYear
[Carrier-mediated Transport of Cationic Drugs across the Blood-Tissue Barrier].
    Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan, 2015, Volume: 135, Issue:10

    Topics: Angiogenesis Inhibitors; Biological Transport; Blood-Brain Barrier; Blood-Retinal Barrier; Cation Tr

2015
[Short and long-term effects of clonidine on sympathetic activity, hemodynamics and renal metabolism of water and sodium in patients with liver cirrhosis].
    Gastroenterologie clinique et biologique, 1992, Volume: 16, Issue:12

    Topics: Clonidine; Diuresis; Glomerular Filtration Rate; Hemodynamics; Humans; Liver Cirrhosis; Natriuresis;

1992
Clonidine in neuropsychiatric disorders: a review.
    The International journal of neuroscience, 1987, Volume: 35, Issue:3-4

    Topics: Clonidine; Humans; Nervous System Diseases

1987
Narcotic withdrawal in the emergency department.
    The American journal of emergency medicine, 1985, Volume: 3, Issue:5

    Topics: Clonidine; Emergency Service, Hospital; Endorphins; Humans; Methadone; Narcotics; Nervous System Dis

1985

Trials

1 trial available for clonidine and Nervous System Disorders

ArticleYear
Cervical sympathetic block to reverse delayed ischemic neurological deficits after aneurysmal subarachnoid hemorrhage.
    Stroke, 2003, Volume: 34, Issue:4

    Topics: Adult; Anesthetics, Local; Angiography, Digital Subtraction; Autonomic Nerve Block; Brain Ischemia;

2003
Cervical sympathetic block to reverse delayed ischemic neurological deficits after aneurysmal subarachnoid hemorrhage.
    Stroke, 2003, Volume: 34, Issue:4

    Topics: Adult; Anesthetics, Local; Angiography, Digital Subtraction; Autonomic Nerve Block; Brain Ischemia;

2003
Cervical sympathetic block to reverse delayed ischemic neurological deficits after aneurysmal subarachnoid hemorrhage.
    Stroke, 2003, Volume: 34, Issue:4

    Topics: Adult; Anesthetics, Local; Angiography, Digital Subtraction; Autonomic Nerve Block; Brain Ischemia;

2003
Cervical sympathetic block to reverse delayed ischemic neurological deficits after aneurysmal subarachnoid hemorrhage.
    Stroke, 2003, Volume: 34, Issue:4

    Topics: Adult; Anesthetics, Local; Angiography, Digital Subtraction; Autonomic Nerve Block; Brain Ischemia;

2003

Other Studies

5 other studies available for clonidine and Nervous System Disorders

ArticleYear
Mechanism-based treatment of pain.
    Pain, 2012, Volume: 153, Issue:11

    Topics: Analgesics; Animals; Clonidine; Diabetic Neuropathies; Female; Humans; Male; Nervous System Diseases

2012
Neurotoxicity of new intraspinal agents.
    Lancet (London, England), 1984, Sep-22, Volume: 2, Issue:8404

    Topics: Analgesia; Clonidine; Humans; Injections, Spinal; Nervous System Diseases; Pain

1984
Detection and measurement of an endogenous clonidine-displacing substance in human cerebrospinal fluid.
    Brain research, 1993, Jan-22, Volume: 601, Issue:1-2

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Binding, Competitive; Cerebrospinal Fluid Proteins; Cere

1993
Autonomic epilepsy: clonidine blockade of paroxysmal catecholamine release and flushing.
    Annals of internal medicine, 1978, Volume: 88, Issue:2

    Topics: Autonomic Nervous System; Carbamazepine; Catecholamines; Climacteric; Clonidine; Epilepsy; Epilepsy,

1978
Tourette's syndrome in Monroe County school children.
    Neurology, 1988, Volume: 38, Issue:3

    Topics: Adolescent; Attention Deficit Disorder with Hyperactivity; Behavior; Child; Child, Preschool; Clonid

1988