clonidine has been researched along with Nausea in 9 studies
Clonidine: An imidazoline sympatholytic agent that stimulates ALPHA-2 ADRENERGIC RECEPTORS and central IMIDAZOLINE RECEPTORS. It is commonly used in the management of HYPERTENSION.
clonidine (amino form) : A clonidine that is 4,5-dihydro-1H-imidazol-2-amine in which one of the amino hydrogens is replaced by a 2,6-dichlorophenyl group.
Nausea: An unpleasant sensation in the stomach usually accompanied by the urge to vomit. Common causes are early pregnancy, sea and motion sickness, emotional stress, intense pain, food poisoning, and various enteroviruses.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We investigated antiemetic effect of clonidine in postoperative nausea and vomiting (PONV) after laparoscopic cholecystectomy." | 9.08 | [Effectiveness of clonidine in postoperative nausea and vomiting--epidural versus oral administration]. ( Ishii, S; Kobayashi, N, 1997) |
| "In preparation for studies of noradrenergic activity in anticipatory nausea and vomiting, we performed an open-dose study of clonidine to examine dose-toxicity relationships and indications of antiemetic activity." | 7.67 | Clonidine for anticipatory nausea and vomiting: a pilot study examining dose-toxicity relationships and potential for further study. ( Enterline, JP; Fetting, JH; Sheidler, VR; Stefanek, ME, 1987) |
| "We investigated antiemetic effect of clonidine in postoperative nausea and vomiting (PONV) after laparoscopic cholecystectomy." | 5.08 | [Effectiveness of clonidine in postoperative nausea and vomiting--epidural versus oral administration]. ( Ishii, S; Kobayashi, N, 1997) |
| "In preparation for studies of noradrenergic activity in anticipatory nausea and vomiting, we performed an open-dose study of clonidine to examine dose-toxicity relationships and indications of antiemetic activity." | 3.67 | Clonidine for anticipatory nausea and vomiting: a pilot study examining dose-toxicity relationships and potential for further study. ( Enterline, JP; Fetting, JH; Sheidler, VR; Stefanek, ME, 1987) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (33.33) | 18.7374 |
| 1990's | 3 (33.33) | 18.2507 |
| 2000's | 3 (33.33) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ma, H | 1 |
| Tang, J | 1 |
| White, PF | 1 |
| Wender, RH | 1 |
| Leverone, T | 1 |
| Quon, R | 1 |
| Pearce, S | 1 |
| Chiao, F | 1 |
| Erice, S | 1 |
| Prasad, S | 1 |
| Harpin, V | 1 |
| Poole, L | 1 |
| Zeitlin, H | 1 |
| Jamdar, S | 1 |
| Puvanendran, K | 1 |
| Hood, DD | 1 |
| Mallak, KA | 1 |
| Eisenach, JC | 1 |
| Tong, C | 1 |
| Kobayashi, N | 1 |
| Ishii, S | 1 |
| Soergel, KH | 1 |
| Greenberger, NJ | 1 |
| Vercauteren, MP | 1 |
| Van de Velde, M | 1 |
| Fetting, JH | 1 |
| Sheidler, VR | 1 |
| Stefanek, ME | 1 |
| Enterline, JP | 1 |
| Hansson, L | 1 |
| Hunyor, SN | 1 |
| Hanington, E | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Hemodynamic Effect of Intrathecal Clonidine in Hypertensive Subjects: A Pilot Study to Assess Its Effectiveness in Hypertensive Subjects With Poor Blood Pressure Control (Phase II)[NCT01297335] | Phase 2 | 10 participants (Actual) | Interventional | 2011-02-28 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
"Subjects baseline blood pressure (systolic blood pressure (SBP), and diastolic blood pressure (DBP)), and blood pressures after clonidine injection was compared against baseline to assess efficacy of clonidine in refractory hypertensive subjects. Subject's blood pressure was monitored continuously after intrathecal injection of clonidine until subjects blood pressure nadir and return to pre clonidine injection level. The mean value reported below are the average changes in blood pressure from baseline (pre clonidine injection) in both SBP and DBP during post clonidine injection blood pressure monitoring for 4 hours.~Blood pressure measurements were collected every 10 minutes for first hour after injection, and every 15 minutes after the first hour, up to 4 hours were averaged to report the change from baseline." (NCT01297335)
Timeframe: Baseline, Every 10 Minutes for first hour after clonidine injection, and every 15 minutes after first hour, until 4 hours after clonidine injection
| Intervention | mm Hg (Mean) | |
|---|---|---|
| Change in mean SBP after clonidine injection | Change in DBP after clonidine injection | |
| Intrathecal Clonidine | 79 | 37 |
Subjects were asked to rate severity of two of the most common side effects of clonidine, sedation and sensation of dry mouth, at pre and post (1 hour after) intrathecal administration of clonidine. The mean changes between pre and post injection VAS ratings of sedation and sensation of dry mouth are reported below. The VAS scale ranges from 1 to 10 cm, with higher values indicating higher level of sedation and higher level of dry mouth. (NCT01297335)
Timeframe: Before clonidine injection (Baseline), and at 1 hour after clonidine injection.
| Intervention | cm (Mean) | |
|---|---|---|
| Change in level of sedation | Change in sensation of dry mouth | |
| Intrathecal Clonidine | 3.36 | 3.47 |
Likert scale is 11 point digital pain rating system that asks subjects to rate their pain from 0 to 10. Rating of 0 means no pain at all, and in increasing order, 10 would mean worst pain imaginable/ unbearable pain. (NCT01297335)
Timeframe: Pre-dose and 1 hour post injection.
| Intervention | units on a scale (Mean) | |
|---|---|---|
| Pre-injection average Likert score | Post-injection average Likert score | |
| Intrathecal Clonidine | 6.5 | 3.6 |
1 review available for clonidine and Nausea
| Article | Year |
|---|---|
Migraine.
Topics: Blood Vessels; Cacao; Cheese; Clonidine; Diet Therapy; Eye Diseases; Food; Headache; Hematologic Dis | 1971 |
3 trials available for clonidine and Nausea
| Article | Year |
|---|---|
A multi-centre, randomised, open-label study of atomoxetine compared with standard current therapy in UK children and adolescents with attention-deficit/hyperactivity disorder (ADHD).
Topics: Adolescent; Adrenergic Uptake Inhibitors; Atomoxetine Hydrochloride; Attention Deficit Disorder with | 2007 |
Interaction between intrathecal neostigmine and epidural clonidine in human volunteers.
Topics: Acetylcholine; Adrenergic alpha-Agonists; Adult; Analgesia, Epidural; Blood Pressure; Cholinesterase | 1996 |
[Effectiveness of clonidine in postoperative nausea and vomiting--epidural versus oral administration].
Topics: Administration, Oral; Adrenergic alpha-Agonists; Adult; Analgesia, Epidural; Anesthesia, General; Ch | 1997 |
5 other studies available for clonidine and Nausea
| Article | Year |
|---|---|
The effect of clonidine on gastrointestinal side effects associated with ultra-rapid opioid detoxification.
Topics: Adrenergic alpha-Agonists; Adult; Clonidine; Diarrhea; Female; Gastrointestinal Diseases; Humans; Hy | 2003 |
Nausea and vomiting in the diabetic patient.
Topics: Adrenergic alpha-Agonists; Algorithms; Clonidine; Diabetes Mellitus, Type 1; Diagnosis, Differential | 1998 |
Neostigmine as the fourth spinal component for labor analgesia?
Topics: Analgesia, Obstetrical; Analgesics; Bupivacaine; Clonidine; Drug Compounding; Drug Therapy, Combinat | 2000 |
Clonidine for anticipatory nausea and vomiting: a pilot study examining dose-toxicity relationships and potential for further study.
Topics: Adult; Clonidine; Dose-Response Relationship, Drug; Female; Humans; Male; Middle Aged; Nausea; Pilot | 1987 |
Blood pressure over-shoot due to acute clonidine (Catapres) withdrawal: studies on arterial and urinary catecholamines and suggestions for management of the crisis.
Topics: Acetanilides; Adrenergic beta-Antagonists; Amino Alcohols; Catecholamines; Clonidine; Headache; Huma | 1973 |