Page last updated: 2024-10-25

clonidine and Nausea

clonidine has been researched along with Nausea in 9 studies

Clonidine: An imidazoline sympatholytic agent that stimulates ALPHA-2 ADRENERGIC RECEPTORS and central IMIDAZOLINE RECEPTORS. It is commonly used in the management of HYPERTENSION.
clonidine (amino form) : A clonidine that is 4,5-dihydro-1H-imidazol-2-amine in which one of the amino hydrogens is replaced by a 2,6-dichlorophenyl group.

Nausea: An unpleasant sensation in the stomach usually accompanied by the urge to vomit. Common causes are early pregnancy, sea and motion sickness, emotional stress, intense pain, food poisoning, and various enteroviruses.

Research Excerpts

ExcerptRelevanceReference
"We investigated antiemetic effect of clonidine in postoperative nausea and vomiting (PONV) after laparoscopic cholecystectomy."9.08[Effectiveness of clonidine in postoperative nausea and vomiting--epidural versus oral administration]. ( Ishii, S; Kobayashi, N, 1997)
"In preparation for studies of noradrenergic activity in anticipatory nausea and vomiting, we performed an open-dose study of clonidine to examine dose-toxicity relationships and indications of antiemetic activity."7.67Clonidine for anticipatory nausea and vomiting: a pilot study examining dose-toxicity relationships and potential for further study. ( Enterline, JP; Fetting, JH; Sheidler, VR; Stefanek, ME, 1987)
"We investigated antiemetic effect of clonidine in postoperative nausea and vomiting (PONV) after laparoscopic cholecystectomy."5.08[Effectiveness of clonidine in postoperative nausea and vomiting--epidural versus oral administration]. ( Ishii, S; Kobayashi, N, 1997)
"In preparation for studies of noradrenergic activity in anticipatory nausea and vomiting, we performed an open-dose study of clonidine to examine dose-toxicity relationships and indications of antiemetic activity."3.67Clonidine for anticipatory nausea and vomiting: a pilot study examining dose-toxicity relationships and potential for further study. ( Enterline, JP; Fetting, JH; Sheidler, VR; Stefanek, ME, 1987)

Research

Studies (9)

TimeframeStudies, this research(%)All Research%
pre-19903 (33.33)18.7374
1990's3 (33.33)18.2507
2000's3 (33.33)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Ma, H1
Tang, J1
White, PF1
Wender, RH1
Leverone, T1
Quon, R1
Pearce, S1
Chiao, F1
Erice, S1
Prasad, S1
Harpin, V1
Poole, L1
Zeitlin, H1
Jamdar, S1
Puvanendran, K1
Hood, DD1
Mallak, KA1
Eisenach, JC1
Tong, C1
Kobayashi, N1
Ishii, S1
Soergel, KH1
Greenberger, NJ1
Vercauteren, MP1
Van de Velde, M1
Fetting, JH1
Sheidler, VR1
Stefanek, ME1
Enterline, JP1
Hansson, L1
Hunyor, SN1
Hanington, E1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Hemodynamic Effect of Intrathecal Clonidine in Hypertensive Subjects: A Pilot Study to Assess Its Effectiveness in Hypertensive Subjects With Poor Blood Pressure Control (Phase II)[NCT01297335]Phase 210 participants (Actual)Interventional2011-02-28Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Change in Blood Pressure After Intrathecal Injection of Clonidine.

"Subjects baseline blood pressure (systolic blood pressure (SBP), and diastolic blood pressure (DBP)), and blood pressures after clonidine injection was compared against baseline to assess efficacy of clonidine in refractory hypertensive subjects. Subject's blood pressure was monitored continuously after intrathecal injection of clonidine until subjects blood pressure nadir and return to pre clonidine injection level. The mean value reported below are the average changes in blood pressure from baseline (pre clonidine injection) in both SBP and DBP during post clonidine injection blood pressure monitoring for 4 hours.~Blood pressure measurements were collected every 10 minutes for first hour after injection, and every 15 minutes after the first hour, up to 4 hours were averaged to report the change from baseline." (NCT01297335)
Timeframe: Baseline, Every 10 Minutes for first hour after clonidine injection, and every 15 minutes after first hour, until 4 hours after clonidine injection

Interventionmm Hg (Mean)
Change in mean SBP after clonidine injectionChange in DBP after clonidine injection
Intrathecal Clonidine7937

Changes in Visual Analogue Scale (VAS) Ratings of Sedation and Sensation of Dry Mouth Reported by the Subjects, Pre and 1 Hour Post Injection

Subjects were asked to rate severity of two of the most common side effects of clonidine, sedation and sensation of dry mouth, at pre and post (1 hour after) intrathecal administration of clonidine. The mean changes between pre and post injection VAS ratings of sedation and sensation of dry mouth are reported below. The VAS scale ranges from 1 to 10 cm, with higher values indicating higher level of sedation and higher level of dry mouth. (NCT01297335)
Timeframe: Before clonidine injection (Baseline), and at 1 hour after clonidine injection.

Interventioncm (Mean)
Change in level of sedationChange in sensation of dry mouth
Intrathecal Clonidine3.363.47

Likert Scale Pain Rating

Likert scale is 11 point digital pain rating system that asks subjects to rate their pain from 0 to 10. Rating of 0 means no pain at all, and in increasing order, 10 would mean worst pain imaginable/ unbearable pain. (NCT01297335)
Timeframe: Pre-dose and 1 hour post injection.

Interventionunits on a scale (Mean)
Pre-injection average Likert scorePost-injection average Likert score
Intrathecal Clonidine6.53.6

Reviews

1 review available for clonidine and Nausea

ArticleYear
Migraine.
    Transactions of the Medical Society of London, 1971, Volume: 87

    Topics: Blood Vessels; Cacao; Cheese; Clonidine; Diet Therapy; Eye Diseases; Food; Headache; Hematologic Dis

1971

Trials

3 trials available for clonidine and Nausea

ArticleYear
A multi-centre, randomised, open-label study of atomoxetine compared with standard current therapy in UK children and adolescents with attention-deficit/hyperactivity disorder (ADHD).
    Current medical research and opinion, 2007, Volume: 23, Issue:2

    Topics: Adolescent; Adrenergic Uptake Inhibitors; Atomoxetine Hydrochloride; Attention Deficit Disorder with

2007
Interaction between intrathecal neostigmine and epidural clonidine in human volunteers.
    Anesthesiology, 1996, Volume: 85, Issue:2

    Topics: Acetylcholine; Adrenergic alpha-Agonists; Adult; Analgesia, Epidural; Blood Pressure; Cholinesterase

1996
[Effectiveness of clonidine in postoperative nausea and vomiting--epidural versus oral administration].
    Masui. The Japanese journal of anesthesiology, 1997, Volume: 46, Issue:4

    Topics: Administration, Oral; Adrenergic alpha-Agonists; Adult; Analgesia, Epidural; Anesthesia, General; Ch

1997

Other Studies

5 other studies available for clonidine and Nausea

ArticleYear
The effect of clonidine on gastrointestinal side effects associated with ultra-rapid opioid detoxification.
    Anesthesia and analgesia, 2003, Volume: 96, Issue:5

    Topics: Adrenergic alpha-Agonists; Adult; Clonidine; Diarrhea; Female; Gastrointestinal Diseases; Humans; Hy

2003
Nausea and vomiting in the diabetic patient.
    Hospital practice (1995), 1998, Feb-15, Volume: 33, Issue:2

    Topics: Adrenergic alpha-Agonists; Algorithms; Clonidine; Diabetes Mellitus, Type 1; Diagnosis, Differential

1998
Neostigmine as the fourth spinal component for labor analgesia?
    Anesthesiology, 2000, Volume: 93, Issue:6

    Topics: Analgesia, Obstetrical; Analgesics; Bupivacaine; Clonidine; Drug Compounding; Drug Therapy, Combinat

2000
Clonidine for anticipatory nausea and vomiting: a pilot study examining dose-toxicity relationships and potential for further study.
    Cancer treatment reports, 1987, Volume: 71, Issue:4

    Topics: Adult; Clonidine; Dose-Response Relationship, Drug; Female; Humans; Male; Middle Aged; Nausea; Pilot

1987
Blood pressure over-shoot due to acute clonidine (Catapres) withdrawal: studies on arterial and urinary catecholamines and suggestions for management of the crisis.
    Clinical science and molecular medicine. Supplement, 1973, Volume: 45 Suppl 1

    Topics: Acetanilides; Adrenergic beta-Antagonists; Amino Alcohols; Catecholamines; Clonidine; Headache; Huma

1973