clonidine has been researched along with Myocardial Ischemia in 33 studies
Clonidine: An imidazoline sympatholytic agent that stimulates ALPHA-2 ADRENERGIC RECEPTORS and central IMIDAZOLINE RECEPTORS. It is commonly used in the management of HYPERTENSION.
clonidine (amino form) : A clonidine that is 4,5-dihydro-1H-imidazol-2-amine in which one of the amino hydrogens is replaced by a 2,6-dichlorophenyl group.
Myocardial Ischemia: A disorder of cardiac function caused by insufficient blood flow to the muscle tissue of the heart. The decreased blood flow may be due to narrowing of the coronary arteries (CORONARY ARTERY DISEASE), to obstruction by a thrombus (CORONARY THROMBOSIS), or less commonly, to diffuse narrowing of arterioles and other small vessels within the heart. Severe interruption of the blood supply to the myocardial tissue may result in necrosis of cardiac muscle (MYOCARDIAL INFARCTION).
| Excerpt | Relevance | Reference |
|---|---|---|
| "To access the clinical effect of clonidine on reduction of myocardial ischemia events in patients with history of coronary artery disease undergoing noncardiac surgeries." | 9.10 | Oral clonidine reduces myocardial ischemia in patients with coronary artery disease undergoing noncardiac surgery. ( Chan, KH; Chow, LH; Chu, CC; Tsai, SK; Tsao, CM; Tsou, MY; Yin, YC, 2002) |
| "The purpose of this study was to determine if clonidine reduces myocardial ischemia or alters anesthetic requirement and perioperative hemodynamic parameters during coronary artery bypass grafting (CABG) surgery." | 9.07 | Clonidine improves perioperative myocardial ischemia, reduces anesthetic requirement, and alters hemodynamic parameters in patients undergoing coronary artery bypass surgery. ( Dorman, BH; Gartman, DM; Slachman, FN; Verrier, ED; Zucker, JR, 1993) |
| " In the subgroup analysis, clonidine reduced the incidence of myocardial ischemia in patients undergoing cardiac and noncardiac surgery." | 8.81 | Efficacy of clonidine for prevention of perioperative myocardial ischemia: a critical appraisal and meta-analysis of the literature. ( Kamae, I; Maekawa, M; Mikawa, K; Nishi, N; Nishina, K; Obara, H; Uesugi, T, 2002) |
| "This study was performed to investigate the effects of clonidine on regional myocardial function in a canine model of regional myocardial ischemia." | 7.69 | The effects of intravenous clonidine on regional myocardial function in a canine model of regional myocardial ischemia. ( Fuke, N; Hayashi, T; Kono, M; Morita, S; Rubsamen, R; Saitoh, M, 1994) |
| "Mivazerol hydrochloride is a new alpha 2-adrenoceptor agonist." | 6.68 | Perioperative sympatholysis. Beneficial effects of the alpha 2-adrenoceptor agonist mivazerol on hemodynamic stability and myocardial ischemia. McSPI--Europe Research Group. ( , 1997) |
| "The incidence of perioperative myocardial ischemia was significantly reduced with clonidine (intraoperative and postoperative, 18 of 125, 14% vs." | 5.11 | Effect of clonidine on cardiovascular morbidity and mortality after noncardiac surgery. ( Boisvert, DM; Galindez, D; Haratonik, KA; Kardatzke, D; Layug, EL; Lazo, EA; Salahieh, A; Wallace, AW, 2004) |
| "To access the clinical effect of clonidine on reduction of myocardial ischemia events in patients with history of coronary artery disease undergoing noncardiac surgeries." | 5.10 | Oral clonidine reduces myocardial ischemia in patients with coronary artery disease undergoing noncardiac surgery. ( Chan, KH; Chow, LH; Chu, CC; Tsai, SK; Tsao, CM; Tsou, MY; Yin, YC, 2002) |
| " clonidine, in addition to general anesthesia, affects the cardiopulmonary bypass- and surgery-associated stress response and incidence of myocardial ischemia by their sympatholytic properties." | 5.09 | High thoracic epidural anesthesia, but not clonidine, attenuates the perioperative stress response via sympatholysis and reduces the release of troponin T in patients undergoing coronary artery bypass grafting. ( Berendes, E; Erren, M; Junker, R; Loick, HM; Meissner, A; Möllhoff, T; Rolf, N; Scheld, HH; Schmid, C; Schmidt, C; Van Aken, H, 1999) |
| " Clonidine reduced enflurane requirements, intraoperative tachycardia, and myocardial ischemia (1/28 clonidine patients vs 5/24 placebo, P = 0." | 5.07 | Premedication with oral and transdermal clonidine provides safe and efficacious postoperative sympatholysis. ( Busse, JR; Drijvers, G; Ellis, JE; Foss, JF; Laff, SP; Mantha, S; McKinsey, JF; Pedlow, S; Shah, M; Sorrentino, MJ, 1994) |
| "The purpose of this study was to determine if clonidine reduces myocardial ischemia or alters anesthetic requirement and perioperative hemodynamic parameters during coronary artery bypass grafting (CABG) surgery." | 5.07 | Clonidine improves perioperative myocardial ischemia, reduces anesthetic requirement, and alters hemodynamic parameters in patients undergoing coronary artery bypass surgery. ( Dorman, BH; Gartman, DM; Slachman, FN; Verrier, ED; Zucker, JR, 1993) |
| " In the subgroup analysis, clonidine reduced the incidence of myocardial ischemia in patients undergoing cardiac and noncardiac surgery." | 4.81 | Efficacy of clonidine for prevention of perioperative myocardial ischemia: a critical appraisal and meta-analysis of the literature. ( Kamae, I; Maekawa, M; Mikawa, K; Nishi, N; Nishina, K; Obara, H; Uesugi, T, 2002) |
| "This study was performed to investigate the effects of clonidine on regional myocardial function in a canine model of regional myocardial ischemia." | 3.69 | The effects of intravenous clonidine on regional myocardial function in a canine model of regional myocardial ischemia. ( Fuke, N; Hayashi, T; Kono, M; Morita, S; Rubsamen, R; Saitoh, M, 1994) |
| "Clonidine was associated with a significant (P < 0." | 2.69 | Clonidine and cardiac surgery: haemodynamic and metabolic effects, myocardial ischaemia and recovery. ( Buckland, MR; Bujor, MA; Davis, BB; Esmore, DS; Hall, J; Holdgaard, HO; Hunt, JO; McRae, R; Moloney, J; Morgan, DJ; Myles, PS, 1999) |
| "Myocardial ischemia was assessed by using continuous electrocardiographic monitoring, beginning 30 min before, and lasting until 24 h after the operation." | 2.69 | The effect of clonidine premedication on hemodynamic responses to microlaryngoscopy and rigid bronchoscopy. ( Gozal, Y; Matot, I; Sichel, JY; Yofe, V, 2000) |
| "Mivazerol hydrochloride is a new alpha 2-adrenoceptor agonist." | 2.68 | Perioperative sympatholysis. Beneficial effects of the alpha 2-adrenoceptor agonist mivazerol on hemodynamic stability and myocardial ischemia. McSPI--Europe Research Group. ( , 1997) |
| "Clonidine is an alpha2-adrenoceptor agonist exerting central sympatholytic effects." | 2.43 | [Clonidine in oral medicine. Literature review and our experience]. ( Grätz, KW; Mutzbauer, TS; Obwegeser, JA, 2005) |
| "It is concluded that automatic arrhythmias induced by alpha 1-adrenergic stimulation during simulated ischemia may be attributed to a specific alpha 1-adrenergic receptor subtype that is blocked by WB-4101." | 1.29 | [The modulation of anomalous automatism in ischemic Purkinje fibers by a specific subclass of alpha 1-adrenoblockers]. ( Aniukhovskiĭ, EP; Rosen, MR, 1993) |
| "Pretreatment with yohimbine (1-10 microM) caused a concentration-dependent increase in reperfusion left ventricular developed pressure and a reduction in end diastolic pressure and lactate dehydrogenase release." | 1.29 | The effect of alpha 2-adrenoceptor antagonists in isolated globally ischemic rat hearts. ( Dzwonczyk, S; Grover, GJ; Sargent, CA, 1994) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 20 (60.61) | 18.2507 |
| 2000's | 10 (30.30) | 29.6817 |
| 2010's | 3 (9.09) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Rorabaugh, BR | 1 |
| Bui, AD | 1 |
| Seeley, SL | 1 |
| Eisenmann, ED | 1 |
| Rose, RM | 1 |
| Johnson, BL | 1 |
| Huntley, MR | 1 |
| Heikkila, ME | 1 |
| Zoladz, PR | 1 |
| Devereaux, PJ | 1 |
| Kolettis, TM | 1 |
| La Rocca, V | 1 |
| Psychalakis, N | 1 |
| Karampela, E | 1 |
| Kontonika, M | 1 |
| Tourmousoglou, C | 1 |
| Baltogiannis, GG | 1 |
| Papalois, A | 1 |
| Kyriakides, ZS | 1 |
| Chalikonda, SA | 1 |
| Catelli, M | 1 |
| Feldman, J | 1 |
| Bousquet, P | 1 |
| Tibirica, E | 1 |
| Yin, YC | 1 |
| Chow, LH | 1 |
| Tsao, CM | 1 |
| Chu, CC | 1 |
| Tsou, MY | 1 |
| Chan, KH | 1 |
| Tsai, SK | 1 |
| Wallace, AW | 1 |
| Galindez, D | 1 |
| Salahieh, A | 1 |
| Layug, EL | 1 |
| Lazo, EA | 1 |
| Haratonik, KA | 1 |
| Boisvert, DM | 1 |
| Kardatzke, D | 1 |
| Boussofara, M | 1 |
| Mtaallah, MH | 1 |
| Nefaa, MN | 1 |
| Kaddour, C | 1 |
| Mutzbauer, TS | 1 |
| Obwegeser, JA | 1 |
| Grätz, KW | 1 |
| Gao, H | 1 |
| Chen, L | 1 |
| Yang, HT | 1 |
| Aniukhovskiĭ, EP | 2 |
| Rosen, MR | 3 |
| Anyukhovsky, EP | 1 |
| Steinberg, SF | 1 |
| Cohen, IS | 1 |
| Tsuchida, A | 1 |
| Liu, Y | 1 |
| Liu, GS | 1 |
| Cohen, MV | 1 |
| Downey, JM | 1 |
| Ellis, JE | 1 |
| Drijvers, G | 1 |
| Pedlow, S | 1 |
| Laff, SP | 1 |
| Sorrentino, MJ | 1 |
| Foss, JF | 1 |
| Shah, M | 1 |
| Busse, JR | 1 |
| Mantha, S | 1 |
| McKinsey, JF | 1 |
| Quíntin, L | 1 |
| Cicala, R | 1 |
| Kent, M | 1 |
| Thomsen, B | 1 |
| Fulgencio, JP | 1 |
| Rimaniol, JM | 1 |
| Catoire, P | 1 |
| Bonnet, F | 1 |
| Sargent, CA | 1 |
| Dzwonczyk, S | 1 |
| Grover, GJ | 1 |
| Dart, AM | 1 |
| Du, XJ | 1 |
| Kono, M | 1 |
| Morita, S | 1 |
| Hayashi, T | 1 |
| Saitoh, M | 1 |
| Fuke, N | 1 |
| Rubsamen, R | 1 |
| Flacke, JW | 1 |
| Flacke, WE | 1 |
| Dorman, BH | 1 |
| Zucker, JR | 1 |
| Verrier, ED | 1 |
| Gartman, DM | 1 |
| Slachman, FN | 1 |
| Geller, JC | 1 |
| Cua, M | 1 |
| Prieto, L | 1 |
| Guo, SD | 1 |
| Danilo, P | 1 |
| Boldt, J | 1 |
| Rothe, G | 1 |
| Schindler, E | 1 |
| Döll, C | 1 |
| Görlach, G | 1 |
| Hempelmann, G | 1 |
| Stühmeier, KD | 1 |
| Mainzer, B | 1 |
| Cierpka, J | 1 |
| Sandmann, W | 1 |
| Tarnow, J | 1 |
| Liu, J | 1 |
| Chen, S | 1 |
| Cao, Q | 1 |
| Zhang, J | 1 |
| Joyeux, M | 1 |
| Godin-Ribuot, D | 1 |
| Patel, A | 1 |
| Demenge, P | 1 |
| Yellon, DM | 1 |
| Ribuot, C | 1 |
| Loick, HM | 1 |
| Schmidt, C | 1 |
| Van Aken, H | 1 |
| Junker, R | 1 |
| Erren, M | 1 |
| Berendes, E | 1 |
| Rolf, N | 1 |
| Meissner, A | 1 |
| Schmid, C | 1 |
| Scheld, HH | 1 |
| Möllhoff, T | 1 |
| Myles, PS | 1 |
| Hunt, JO | 1 |
| Holdgaard, HO | 1 |
| McRae, R | 1 |
| Buckland, MR | 1 |
| Moloney, J | 1 |
| Hall, J | 1 |
| Bujor, MA | 1 |
| Esmore, DS | 1 |
| Davis, BB | 1 |
| Morgan, DJ | 1 |
| Matot, I | 1 |
| Sichel, JY | 1 |
| Yofe, V | 1 |
| Gozal, Y | 1 |
| Arnar, DO | 1 |
| Xing, D | 1 |
| Lee, H | 1 |
| Martins, JB | 1 |
| Nishina, K | 1 |
| Mikawa, K | 1 |
| Uesugi, T | 1 |
| Obara, H | 1 |
| Maekawa, M | 1 |
| Kamae, I | 1 |
| Nishi, N | 1 |
| Rozen, MP | 1 |
| Staĭnberg, SF | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Large, International, Placebo-controlled, Factorial Trial to Assess the Impact of Clonidine and Acetyl-salicylic Acid (ASA) in Patients Undergoing Noncardiac Surgery Who Are at Risk of a Perioperative Cardiovascular Event[NCT01082874] | Phase 3 | 10,010 participants (Actual) | Interventional | 2010-07-31 | Completed | ||
| Hemodynamic Effect of Intrathecal Clonidine in Hypertensive Subjects: A Pilot Study to Assess Its Effectiveness in Hypertensive Subjects With Poor Blood Pressure Control (Phase II)[NCT01297335] | Phase 2 | 10 participants (Actual) | Interventional | 2011-02-28 | Completed | ||
| Effects of Clonidine and Midazolam Premedication on Bispectral Index and Recovery After Elective Surgery[NCT00638729] | 60 participants (Actual) | Interventional | 2005-08-31 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
(NCT01082874)
Timeframe: 30 days
| Intervention | participants (Number) |
|---|---|
| Active Clonidine and Active ASA | 173 |
| Active Clonidine and Placebo ASA | 194 |
| Placebo Clonidine and Active ASA | 178 |
| Placebo Clonidine and Placebo ASA | 161 |
"Subjects baseline blood pressure (systolic blood pressure (SBP), and diastolic blood pressure (DBP)), and blood pressures after clonidine injection was compared against baseline to assess efficacy of clonidine in refractory hypertensive subjects. Subject's blood pressure was monitored continuously after intrathecal injection of clonidine until subjects blood pressure nadir and return to pre clonidine injection level. The mean value reported below are the average changes in blood pressure from baseline (pre clonidine injection) in both SBP and DBP during post clonidine injection blood pressure monitoring for 4 hours.~Blood pressure measurements were collected every 10 minutes for first hour after injection, and every 15 minutes after the first hour, up to 4 hours were averaged to report the change from baseline." (NCT01297335)
Timeframe: Baseline, Every 10 Minutes for first hour after clonidine injection, and every 15 minutes after first hour, until 4 hours after clonidine injection
| Intervention | mm Hg (Mean) | |
|---|---|---|
| Change in mean SBP after clonidine injection | Change in DBP after clonidine injection | |
| Intrathecal Clonidine | 79 | 37 |
Subjects were asked to rate severity of two of the most common side effects of clonidine, sedation and sensation of dry mouth, at pre and post (1 hour after) intrathecal administration of clonidine. The mean changes between pre and post injection VAS ratings of sedation and sensation of dry mouth are reported below. The VAS scale ranges from 1 to 10 cm, with higher values indicating higher level of sedation and higher level of dry mouth. (NCT01297335)
Timeframe: Before clonidine injection (Baseline), and at 1 hour after clonidine injection.
| Intervention | cm (Mean) | |
|---|---|---|
| Change in level of sedation | Change in sensation of dry mouth | |
| Intrathecal Clonidine | 3.36 | 3.47 |
Likert scale is 11 point digital pain rating system that asks subjects to rate their pain from 0 to 10. Rating of 0 means no pain at all, and in increasing order, 10 would mean worst pain imaginable/ unbearable pain. (NCT01297335)
Timeframe: Pre-dose and 1 hour post injection.
| Intervention | units on a scale (Mean) | |
|---|---|---|
| Pre-injection average Likert score | Post-injection average Likert score | |
| Intrathecal Clonidine | 6.5 | 3.6 |
5 reviews available for clonidine and Myocardial Ischemia
| Article | Year |
|---|---|
Alpha2-adrenergic agonists and their role in the prevention of perioperative adverse cardiac events.
Topics: Adrenergic alpha-Agonists; Clonidine; Dexmedetomidine; Humans; Imidazoles; Myocardial Ischemia; Post | 2009 |
[Clonidine and anesthesia].
Topics: Adrenergic alpha-Agonists; Analgesia; Analgesics; Analgesics, Non-Narcotic; Anesthesia; Anesthetics, | 2004 |
[Clonidine in oral medicine. Literature review and our experience].
Topics: Administration, Oral; Adrenergic alpha-Agonists; Anesthesia, Dental; Anesthesia, Local; Clonidine; C | 2005 |
Unexpected drug effects on autonomic function during myocardial ischaemia.
Topics: Adrenergic beta-Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animals; Autonomic Nervous Sy | 1993 |
Efficacy of clonidine for prevention of perioperative myocardial ischemia: a critical appraisal and meta-analysis of the literature.
Topics: Adrenergic alpha-Agonists; Clinical Trials as Topic; Clonidine; Humans; Intraoperative Complications | 2002 |
13 trials available for clonidine and Myocardial Ischemia
| Article | Year |
|---|---|
Rationale and design of the PeriOperative ISchemic Evaluation-2 (POISE-2) trial: an international 2 × 2 factorial randomized controlled trial of acetyl-salicylic acid vs. placebo and clonidine vs. placebo in patients undergoing noncardiac surgery.
Topics: Aged; Aspirin; Clonidine; Double-Blind Method; Female; Humans; Intraoperative Complications; Male; M | 2014 |
Oral clonidine reduces myocardial ischemia in patients with coronary artery disease undergoing noncardiac surgery.
Topics: Administration, Oral; Aged; Blood Pressure; Clonidine; Coronary Disease; Double-Blind Method; Electr | 2002 |
Effect of clonidine on cardiovascular morbidity and mortality after noncardiac surgery.
Topics: Adrenergic alpha-Agonists; Aged; Anesthesia; Arrhythmias, Cardiac; Cardiovascular Diseases; Catechol | 2004 |
Premedication with oral and transdermal clonidine provides safe and efficacious postoperative sympatholysis.
Topics: Administration, Cutaneous; Administration, Oral; Aged; Anesthesia; Clonidine; Coronary Disease; Doub | 1994 |
Effect of clonidine on myocardial ischaemia: a double-blind pilot trial.
Topics: Anesthesia, Intravenous; Cardiopulmonary Bypass; Clonidine; Double-Blind Method; Electrocardiography | 1993 |
Clonidine and postoperative myocardial ischaemia.
Topics: Aged; Analgesia, Epidural; Aorta, Abdominal; Blood Pressure; Clonidine; Double-Blind Method; Drug Co | 1994 |
Clonidine improves perioperative myocardial ischemia, reduces anesthetic requirement, and alters hemodynamic parameters in patients undergoing coronary artery bypass surgery.
Topics: Anesthesia, Intravenous; Blood Pressure; Cardiac Output; Cardiac Pacing, Artificial; Clonidine; Coro | 1993 |
Can clonidine, enoximone, and enalaprilat help to protect the myocardium against ischaemia in cardiac surgery?
Topics: Adrenergic alpha-Agonists; Angiotensin-Converting Enzyme Inhibitors; Biomarkers; Cardiac Surgical Pr | 1996 |
Small, oral dose of clonidine reduces the incidence of intraoperative myocardial ischemia in patients having vascular surgery.
Topics: Administration, Oral; Adrenergic alpha-Agonists; Adult; Aged; Aged, 80 and over; Blood Pressure; Clo | 1996 |
Perioperative sympatholysis. Beneficial effects of the alpha 2-adrenoceptor agonist mivazerol on hemodynamic stability and myocardial ischemia. McSPI--Europe Research Group.
Topics: Adrenergic alpha-Agonists; Aged; Analgesics; Anesthetics; Blood Pressure; Clonidine; Double-Blind Me | 1997 |
High thoracic epidural anesthesia, but not clonidine, attenuates the perioperative stress response via sympatholysis and reduces the release of troponin T in patients undergoing coronary artery bypass grafting.
Topics: Adrenergic alpha-Agonists; Adult; Aged; Aged, 80 and over; Anesthesia, Epidural; Anesthesia, General | 1999 |
Clonidine and cardiac surgery: haemodynamic and metabolic effects, myocardial ischaemia and recovery.
Topics: Adrenergic alpha-Agonists; Aged; Anesthetics, Intravenous; Clonidine; Coronary Artery Bypass; Creati | 1999 |
The effect of clonidine premedication on hemodynamic responses to microlaryngoscopy and rigid bronchoscopy.
Topics: Adrenergic alpha-Agonists; Aged; Arrhythmias, Cardiac; Blood Pressure; Bronchoscopy; Chi-Square Dist | 2000 |
15 other studies available for clonidine and Myocardial Ischemia
| Article | Year |
|---|---|
Myocardial hypersensitivity to ischemic injury is not reversed by clonidine or propranolol in a predator-based rat model of posttraumatic stress disorder.
Topics: Adrenergic Agents; Animals; Anxiety; Cardiovascular Agents; Clonidine; Disease Models, Animal; Disea | 2019 |
Effects of central sympathetic activation on repolarization-dispersion during short-term myocardial ischemia in anesthetized rats.
Topics: Anesthesia; Animals; Clonidine; Electrocardiography; Heart Rate; Ligation; Male; Myocardial Ischemia | 2016 |
Protective effects of centrally acting sympathomodulatory drugs on myocardial ischemia induced by sympathetic overactivity in rabbits.
Topics: Adrenergic beta-Antagonists; Animals; Antihypertensive Agents; Blood Pressure; Clonidine; Electrocar | 2003 |
Activation of alpha1B-adrenoceptors alleviates ischemia/reperfusion injury by limitation of mitochondrial Ca2+ overload in cardiomyocytes.
Topics: Adenosine Triphosphate; Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-Antagonists; Anima | 2007 |
[The modulation of anomalous automatism in ischemic Purkinje fibers by a specific subclass of alpha 1-adrenoblockers].
Topics: Action Potentials; Adrenergic alpha-Antagonists; Analysis of Variance; Animals; Arrhythmias, Cardiac | 1993 |
Receptor-effector coupling pathway for alpha 1-adrenergic modulation of abnormal automaticity in 'ischemic' canine Purkinje fibers.
Topics: Adrenergic alpha-Antagonists; Animals; Barium; Clonidine; Dioxanes; Dogs; Membrane Potentials; Myoca | 1994 |
alpha 1-adrenergic agonists precondition rabbit ischemic myocardium independent of adenosine by direct activation of protein kinase C.
Topics: Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-Antagonists; Analysis of Variance; Animals | 1994 |
The effect of alpha 2-adrenoceptor antagonists in isolated globally ischemic rat hearts.
Topics: Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Antagonists; Animals; Blood Pressure; Clon | 1994 |
The effects of intravenous clonidine on regional myocardial function in a canine model of regional myocardial ischemia.
Topics: Animals; Clonidine; Dogs; Female; Heart; Hemodynamics; Injections, Intravenous; Male; Myocardial Isc | 1994 |
Clonidine prevention of myocardial ischemia during cardiac surgery: will this change outcome?
Topics: Bradycardia; Cardiac Output; Cardiac Pacing, Artificial; Clonidine; Coronary Artery Bypass; Heart; H | 1993 |
Chloroethylclonidine increases the incidence of lethal arrhythmias during coronary occlusion in anesthetized dogs.
Topics: Adrenergic alpha-Antagonists; Animals; Arrhythmias, Cardiac; Clonidine; Dioxanes; Dogs; Female; Male | 1995 |
[Influence of microinjection of clonidine and yohimbine in rVLM on the effect of electroacupuncture treatment of myocardial ischemia].
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Clonidine; Electroacupuncture; Fem | 1996 |
Infarct size-reducing effect of heat stress and alpha1 adrenoceptors in rats.
Topics: Adrenergic alpha-Antagonists; Animals; Clonidine; Heat Stress Disorders; Heat-Shock Proteins; HSP72 | 1998 |
Prevention of ischemic ventricular tachycardia of Purkinje origin: role for alpha(2)-adrenoceptors in Purkinje?
Topics: Adrenergic alpha-Agonists; Animals; Blood Pressure; Clonidine; Coronary Disease; Dogs; Electrocardio | 2001 |
[Modulation of heart rhythm by alpha-1 adrenoreceptors].
Topics: Animals; Arrhythmias, Cardiac; Clonidine; Dioxanes; Dogs; Electrocardiography; Heart Rate; Myocardia | 1992 |