clonidine has been researched along with Mydriasis in 14 studies
Clonidine: An imidazoline sympatholytic agent that stimulates ALPHA-2 ADRENERGIC RECEPTORS and central IMIDAZOLINE RECEPTORS. It is commonly used in the management of HYPERTENSION.
clonidine (amino form) : A clonidine that is 4,5-dihydro-1H-imidazol-2-amine in which one of the amino hydrogens is replaced by a 2,6-dichlorophenyl group.
Mydriasis: Dilation of pupils to greater than 6 mm combined with failure of the pupils to constrict when stimulated with light. This condition may occur due to injury of the pupillary fibers in the oculomotor nerve, in acute angle-closure glaucoma, and in ADIE SYNDROME.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The clonidine mydriasis model in rats has been widely applied in preclinical research to characterize alpha(2)-adrenoceptor antagonistic properties of drugs." | 7.73 | Rat clonidine mydriasis model: imidazoline receptors are not involved. ( Koss, MC; Yu, Y, 2005) |
| "The relationship between concentration and inhibitory effect of the alpha 2-adrenoceptor antagonist idazoxan on clonidine-induced mydriasis has been studied in the rat using pharmacokinetic-pharmacodynamic simultaneous modelling." | 7.69 | A pharmacokinetic-pharmacodynamic linking model for the alpha 2-adrenergic antagonism of idazoxan on clonidine-induced mydriasis in the rat. ( Jane, F; Menargues, A; Obach, R; Pruñonosa, J; Valles, J, 1995) |
| " Clonidine did not significantly reduce the mydriatic effects of MDMA, although it produced miosis when administered alone." | 4.88 | Effects of MDMA alone and after pretreatment with reboxetine, duloxetine, clonidine, carvedilol, and doxazosin on pupillary light reflex. ( Hysek, CM; Liechti, ME, 2012) |
| "The clonidine mydriasis model in rats has been widely applied in preclinical research to characterize alpha(2)-adrenoceptor antagonistic properties of drugs." | 3.73 | Rat clonidine mydriasis model: imidazoline receptors are not involved. ( Koss, MC; Yu, Y, 2005) |
| "Apraclonidine testing, which is easy to perform and not distressing to the patient, identified PSD in nearly half of DM patients, the degree of mydriasis being correlated to the duration of DM and the presence of DR." | 3.73 | Topical apraclonidine testing discloses pupillary sympathetic denervation in diabetic patients. ( Firat, E; Kansu, T; Kavuncu, S; Koc, F, 2006) |
| " ligand displacement of [3H]2-(2-methoxy)-1,4-benzodioxan-2-yl)-2-imidazoline ([3H]RX 821002) from membranes prepared from rat cortex after noradrenergic denervation and, secondly, by antagonism of clonidine-induced mydriasis." | 3.69 | Receptor binding and functional evidence suggest that postsynaptic alpha 2-adrenoceptors in rat brain are of the alpha 2D subtype. ( Buckett, WR; Butler, SA; Cheetham, SC; Gosden, J; Heal, DJ; Prow, MR, 1995) |
| "The relationship between concentration and inhibitory effect of the alpha 2-adrenoceptor antagonist idazoxan on clonidine-induced mydriasis has been studied in the rat using pharmacokinetic-pharmacodynamic simultaneous modelling." | 3.69 | A pharmacokinetic-pharmacodynamic linking model for the alpha 2-adrenergic antagonism of idazoxan on clonidine-induced mydriasis in the rat. ( Jane, F; Menargues, A; Obach, R; Pruñonosa, J; Valles, J, 1995) |
| " ABT-200 also antagonized clonidine-induced mydriasis and increased the overflow of [3H]-norepinephrine in guinea pig hippocampal slices, manifestations of blockade of alpha-2 adrenoceptors in the central nervous system." | 3.69 | Preclinical pharmacological actions of (+/-)-(1'R*,3R*)-3-phenyl-1- [1',2',3',4'-tetrahydro-5',6'-methylene-dioxy-1'-naphthalenyl) methyl] pyrrolidine methanesulfonate (ABT-200), a potential antidepressant agent that antagonizes alpha-2 adrenergic recepto ( Brune, ME; Buckner, SA; Giardina, WJ; Hancock, AA; Kerkman, DJ; Lee, JY; Morse, PA; Oheim, KW; Stanisic, DS; Warner, RB, 1995) |
| "The specific binding of the agonist, [3H]UK 14304, and of the antagonist, [3H]RX 821002, to rat brain membranes, as well as clonidine-induced mydriasis, clonidine-induced inhibition and idazoxan-induced stimulation of brain 3,4-dihydroxyphenylalanine (DOPA) synthesis, and clonidine and UK 14304-induced inhibition of twitch responses in the vas deferens were used to evaluate the affinity and sensitivity of central and peripheral alpha 2-adrenoceptors after various treatments with reserpine." | 3.68 | Acute and chronic effects of reserpine on biochemical and functional parameters of central and peripheral alpha 2-adrenoceptors. ( García-Sevilla, JA; Garro, MA; Giralt, MT; Menargues, A; Miralles, A; Obach, R; Olmos, G; Pineda, J; Ugedo, L, 1993) |
| "The specific binding of the agonist [corrected], [3H]clonidine, to neural membranes and clonidine-induced mydriasis were used to evaluate the density and sensitivity [corrected] of alpha 2-adrenoceptors in the brain of spontaneously hypertensive rats (SHR) and sex- and age-matched normotensive Wistar-Kyoto (WKY) rats." | 3.68 | Decreased density and sensitivity of alpha 2-adrenoceptors in the brain of spontaneously hypertensive rats. ( Barturen, F; García-Sevilla, JA; Miralles, A; Olmos, G, 1991) |
| "Clonidine was a more potent inhibitor of fluctuations but significantly enhanced the light reflex." | 1.28 | Separate neural mechanisms mediate sufentanil-induced pupillary responses in the cat. ( Sharpe, LG, 1991) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 8 (57.14) | 18.2507 |
| 2000's | 2 (14.29) | 29.6817 |
| 2010's | 3 (21.43) | 24.3611 |
| 2020's | 1 (7.14) | 2.80 |
| Authors | Studies |
|---|---|
| González Martín-Moro, J | 1 |
| Mittendrein, V | 1 |
| Pilo de la Fuente, B | 1 |
| Gutiérrez-Ortiz, C | 1 |
| Slattery, A | 1 |
| Liebelt, E | 1 |
| Gaines, LA | 1 |
| Malem, A | 1 |
| Hysek, CM | 1 |
| Liechti, ME | 1 |
| Yu, Y | 1 |
| Koss, MC | 1 |
| Koc, F | 1 |
| Kansu, T | 1 |
| Kavuncu, S | 1 |
| Firat, E | 1 |
| Heal, DJ | 2 |
| Cheetham, SC | 1 |
| Butler, SA | 1 |
| Gosden, J | 1 |
| Prow, MR | 2 |
| Buckett, WR | 2 |
| Valles, J | 1 |
| Obach, R | 2 |
| Menargues, A | 2 |
| Pruñonosa, J | 1 |
| Jane, F | 1 |
| Hancock, AA | 1 |
| Buckner, SA | 1 |
| Giardina, WJ | 1 |
| Brune, ME | 1 |
| Lee, JY | 1 |
| Morse, PA | 1 |
| Oheim, KW | 1 |
| Stanisic, DS | 1 |
| Warner, RB | 1 |
| Kerkman, DJ | 1 |
| Ugedo, L | 1 |
| Garro, MA | 1 |
| Pineda, J | 1 |
| Giralt, MT | 1 |
| Miralles, A | 2 |
| Olmos, G | 2 |
| García-Sevilla, JA | 2 |
| Redfern, WS | 1 |
| Williams, A | 1 |
| Barturen, F | 1 |
| Sharpe, LG | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Pharmacological Interaction Between Duloxetine and 3,4-Methylenedioxymethamphetamine (MDMA, Ecstasy): Pharmacodynamics (PD) and Pharmacokinetics (PK)[NCT00990067] | Phase 1 | 16 participants (Actual) | Interventional | 2009-11-30 | Completed | ||
| Pharmacological Interaction Between Reboxetine and 3,4-Methylenedioxymethamphetamine (MDMA, Ecstasy): Pharmacological Effects and Pharmacokinetics[NCT00886886] | Phase 1 | 16 participants (Actual) | Interventional | 2009-04-30 | Completed | ||
| Pharmacological Interaction Between Clonidine and 3,4-methylenedioxymethamphetamine (MDMA, Ecstasy)[NCT01136278] | Phase 1 | 16 participants (Actual) | Interventional | 2010-07-31 | Completed | ||
| Interactive Effects of Doxazosin and 3,4-Methylenedioxymethamphetamine (MDMA) in Healthy Subjects[NCT01386177] | Phase 1 | 16 participants (Actual) | Interventional | 2011-07-31 | Completed | ||
| "Effects of Carvedilol on the Cardiovascular and Subjective Response to MDMA (3,4-Methylenedioxymethamphetamine, Ecstasy)"[NCT01270672] | 16 participants (Actual) | Interventional | 2011-01-31 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for clonidine and Mydriasis
| Article | Year |
|---|---|
Common ocular effects reported to a poison control center after systemic absorption of drugs in therapeutic and toxic doses.
Topics: Amphetamines; Analgesics, Opioid; Clonidine; Dextromethorphan; Humans; Miosis; Mydriasis; Nystagmus, | 2014 |
Effects of MDMA alone and after pretreatment with reboxetine, duloxetine, clonidine, carvedilol, and doxazosin on pupillary light reflex.
Topics: Adrenergic Agonists; Adrenergic alpha-2 Receptor Agonists; Adrenergic Uptake Inhibitors; Adult; Affe | 2012 |
Effects of MDMA alone and after pretreatment with reboxetine, duloxetine, clonidine, carvedilol, and doxazosin on pupillary light reflex.
Topics: Adrenergic Agonists; Adrenergic alpha-2 Receptor Agonists; Adrenergic Uptake Inhibitors; Adult; Affe | 2012 |
Effects of MDMA alone and after pretreatment with reboxetine, duloxetine, clonidine, carvedilol, and doxazosin on pupillary light reflex.
Topics: Adrenergic Agonists; Adrenergic alpha-2 Receptor Agonists; Adrenergic Uptake Inhibitors; Adult; Affe | 2012 |
Effects of MDMA alone and after pretreatment with reboxetine, duloxetine, clonidine, carvedilol, and doxazosin on pupillary light reflex.
Topics: Adrenergic Agonists; Adrenergic alpha-2 Receptor Agonists; Adrenergic Uptake Inhibitors; Adult; Affe | 2012 |
Effects of MDMA alone and after pretreatment with reboxetine, duloxetine, clonidine, carvedilol, and doxazosin on pupillary light reflex.
Topics: Adrenergic Agonists; Adrenergic alpha-2 Receptor Agonists; Adrenergic Uptake Inhibitors; Adult; Affe | 2012 |
Effects of MDMA alone and after pretreatment with reboxetine, duloxetine, clonidine, carvedilol, and doxazosin on pupillary light reflex.
Topics: Adrenergic Agonists; Adrenergic alpha-2 Receptor Agonists; Adrenergic Uptake Inhibitors; Adult; Affe | 2012 |
Effects of MDMA alone and after pretreatment with reboxetine, duloxetine, clonidine, carvedilol, and doxazosin on pupillary light reflex.
Topics: Adrenergic Agonists; Adrenergic alpha-2 Receptor Agonists; Adrenergic Uptake Inhibitors; Adult; Affe | 2012 |
Effects of MDMA alone and after pretreatment with reboxetine, duloxetine, clonidine, carvedilol, and doxazosin on pupillary light reflex.
Topics: Adrenergic Agonists; Adrenergic alpha-2 Receptor Agonists; Adrenergic Uptake Inhibitors; Adult; Affe | 2012 |
Effects of MDMA alone and after pretreatment with reboxetine, duloxetine, clonidine, carvedilol, and doxazosin on pupillary light reflex.
Topics: Adrenergic Agonists; Adrenergic alpha-2 Receptor Agonists; Adrenergic Uptake Inhibitors; Adult; Affe | 2012 |
Effects of MDMA alone and after pretreatment with reboxetine, duloxetine, clonidine, carvedilol, and doxazosin on pupillary light reflex.
Topics: Adrenergic Agonists; Adrenergic alpha-2 Receptor Agonists; Adrenergic Uptake Inhibitors; Adult; Affe | 2012 |
Effects of MDMA alone and after pretreatment with reboxetine, duloxetine, clonidine, carvedilol, and doxazosin on pupillary light reflex.
Topics: Adrenergic Agonists; Adrenergic alpha-2 Receptor Agonists; Adrenergic Uptake Inhibitors; Adult; Affe | 2012 |
Effects of MDMA alone and after pretreatment with reboxetine, duloxetine, clonidine, carvedilol, and doxazosin on pupillary light reflex.
Topics: Adrenergic Agonists; Adrenergic alpha-2 Receptor Agonists; Adrenergic Uptake Inhibitors; Adult; Affe | 2012 |
Effects of MDMA alone and after pretreatment with reboxetine, duloxetine, clonidine, carvedilol, and doxazosin on pupillary light reflex.
Topics: Adrenergic Agonists; Adrenergic alpha-2 Receptor Agonists; Adrenergic Uptake Inhibitors; Adult; Affe | 2012 |
Effects of MDMA alone and after pretreatment with reboxetine, duloxetine, clonidine, carvedilol, and doxazosin on pupillary light reflex.
Topics: Adrenergic Agonists; Adrenergic alpha-2 Receptor Agonists; Adrenergic Uptake Inhibitors; Adult; Affe | 2012 |
Effects of MDMA alone and after pretreatment with reboxetine, duloxetine, clonidine, carvedilol, and doxazosin on pupillary light reflex.
Topics: Adrenergic Agonists; Adrenergic alpha-2 Receptor Agonists; Adrenergic Uptake Inhibitors; Adult; Affe | 2012 |
Effects of MDMA alone and after pretreatment with reboxetine, duloxetine, clonidine, carvedilol, and doxazosin on pupillary light reflex.
Topics: Adrenergic Agonists; Adrenergic alpha-2 Receptor Agonists; Adrenergic Uptake Inhibitors; Adult; Affe | 2012 |
Effects of MDMA alone and after pretreatment with reboxetine, duloxetine, clonidine, carvedilol, and doxazosin on pupillary light reflex.
Topics: Adrenergic Agonists; Adrenergic alpha-2 Receptor Agonists; Adrenergic Uptake Inhibitors; Adult; Affe | 2012 |
Effects of MDMA alone and after pretreatment with reboxetine, duloxetine, clonidine, carvedilol, and doxazosin on pupillary light reflex.
Topics: Adrenergic Agonists; Adrenergic alpha-2 Receptor Agonists; Adrenergic Uptake Inhibitors; Adult; Affe | 2012 |
Effects of MDMA alone and after pretreatment with reboxetine, duloxetine, clonidine, carvedilol, and doxazosin on pupillary light reflex.
Topics: Adrenergic Agonists; Adrenergic alpha-2 Receptor Agonists; Adrenergic Uptake Inhibitors; Adult; Affe | 2012 |
Effects of MDMA alone and after pretreatment with reboxetine, duloxetine, clonidine, carvedilol, and doxazosin on pupillary light reflex.
Topics: Adrenergic Agonists; Adrenergic alpha-2 Receptor Agonists; Adrenergic Uptake Inhibitors; Adult; Affe | 2012 |
Effects of MDMA alone and after pretreatment with reboxetine, duloxetine, clonidine, carvedilol, and doxazosin on pupillary light reflex.
Topics: Adrenergic Agonists; Adrenergic alpha-2 Receptor Agonists; Adrenergic Uptake Inhibitors; Adult; Affe | 2012 |
Effects of MDMA alone and after pretreatment with reboxetine, duloxetine, clonidine, carvedilol, and doxazosin on pupillary light reflex.
Topics: Adrenergic Agonists; Adrenergic alpha-2 Receptor Agonists; Adrenergic Uptake Inhibitors; Adult; Affe | 2012 |
Effects of MDMA alone and after pretreatment with reboxetine, duloxetine, clonidine, carvedilol, and doxazosin on pupillary light reflex.
Topics: Adrenergic Agonists; Adrenergic alpha-2 Receptor Agonists; Adrenergic Uptake Inhibitors; Adult; Affe | 2012 |
Effects of MDMA alone and after pretreatment with reboxetine, duloxetine, clonidine, carvedilol, and doxazosin on pupillary light reflex.
Topics: Adrenergic Agonists; Adrenergic alpha-2 Receptor Agonists; Adrenergic Uptake Inhibitors; Adult; Affe | 2012 |
Effects of MDMA alone and after pretreatment with reboxetine, duloxetine, clonidine, carvedilol, and doxazosin on pupillary light reflex.
Topics: Adrenergic Agonists; Adrenergic alpha-2 Receptor Agonists; Adrenergic Uptake Inhibitors; Adult; Affe | 2012 |
12 other studies available for clonidine and Mydriasis
| Article | Year |
|---|---|
Eponyms related to oculosympathetic paresis, the apraclonidine test and the comeback of Pourfour du Petit.
Topics: Clonidine; Eponyms; Humans; Mydriasis; Paresis | 2022 |
Unequal pupils and ptosis.
Topics: Adrenergic alpha-2 Receptor Agonists; Aged; Anisocoria; Blepharoptosis; Carotid Arteries; Clonidine; | 2017 |
Rat clonidine mydriasis model: imidazoline receptors are not involved.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Clonidine; Disease Models, Animal; | 2005 |
Topical apraclonidine testing discloses pupillary sympathetic denervation in diabetic patients.
Topics: Administration, Topical; Adrenergic alpha-Agonists; Clonidine; Diabetic Nephropathies; Disease Progr | 2006 |
Receptor binding and functional evidence suggest that postsynaptic alpha 2-adrenoceptors in rat brain are of the alpha 2D subtype.
Topics: Adrenergic Agents; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Benzylamines; B | 1995 |
A pharmacokinetic-pharmacodynamic linking model for the alpha 2-adrenergic antagonism of idazoxan on clonidine-induced mydriasis in the rat.
Topics: Administration, Oral; Adrenergic alpha-Antagonists; Animals; Chromatography, High Pressure Liquid; C | 1995 |
Preclinical pharmacological actions of (+/-)-(1'R*,3R*)-3-phenyl-1- [1',2',3',4'-tetrahydro-5',6'-methylene-dioxy-1'-naphthalenyl) methyl] pyrrolidine methanesulfonate (ABT-200), a potential antidepressant agent that antagonizes alpha-2 adrenergic recepto
Topics: Adrenergic alpha-2 Receptor Antagonists; Adrenergic Uptake Inhibitors; Animals; Antidepressive Agent | 1995 |
Acute and chronic effects of reserpine on biochemical and functional parameters of central and peripheral alpha 2-adrenoceptors.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Binding Sites; Brain; Brimonidine | 1993 |
A re-evaluation of the role of alpha 2-adrenoceptors in the anxiogenic effects of yohimbine, using the selective antagonist delequamine in the rat.
Topics: Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Antagonists; Amphetamine; Animals; Behavio | 1995 |
Decreased density and sensitivity of alpha 2-adrenoceptors in the brain of spontaneously hypertensive rats.
Topics: Animals; Brain; Clonidine; Hypertension; Male; Mydriasis; Pupil; Radioligand Assay; Rats; Rats, Inbr | 1991 |
Separate neural mechanisms mediate sufentanil-induced pupillary responses in the cat.
Topics: Analgesics, Opioid; Animals; Cats; Clonidine; Drug Interactions; Fentanyl; Male; Morphine; Mydriasis | 1991 |
Effects of antidepressant drugs and electroconvulsive shock on pre- and postsynaptic alpha 2-adrenoceptor function in the brain: rapid down-regulation by sibutramine hydrochloride.
Topics: Animals; Antidepressive Agents; Biogenic Amines; Brain; Brain Chemistry; Clonidine; Cyclobutanes; Do | 1991 |