Page last updated: 2024-10-25

clonidine and Muscle Relaxation

clonidine has been researched along with Muscle Relaxation in 42 studies

Clonidine: An imidazoline sympatholytic agent that stimulates ALPHA-2 ADRENERGIC RECEPTORS and central IMIDAZOLINE RECEPTORS. It is commonly used in the management of HYPERTENSION.
clonidine (amino form) : A clonidine that is 4,5-dihydro-1H-imidazol-2-amine in which one of the amino hydrogens is replaced by a 2,6-dichlorophenyl group.

Muscle Relaxation: That phase of a muscle twitch during which a muscle returns to a resting position.

Research Excerpts

ExcerptRelevanceReference
" effect of test drug on clonidine and haloperidol induced catalepsy, milk-induced leukocytosis and eosinophilia, mast cell stabilizing activity in mice and studies on smooth muscle preparation of guinea pig ileum (in-vitro)."3.88Antiallergic and antihistaminic actions of Ceasalpinia bonducella seeds: Possible role in treatment of asthma. ( Nirmal, S; Vikhe, S, 2018)
"In phenoxybenzamine-pretreated preparations, Sgd 101/75 (400 microM) did not antagonise NA (maximal effect and EC50 values not changed significantly), so it was concluded that Sgd 101/75 and NA interact with different alpha 1-adrenoceptor subtypes in this tissue."2.36Sgd 101/75: a sympathomimetic that can be used to identify a new subtype of alpha-adrenoceptor, the alpha 1s-adrenoceptor. ( Chadwick, MA; Coates, J; Ismail, S; Jahn, U; Lawson, K; Thiele, K; Turner, N; Weetman, DF, 1983)
" Dose-response curves for adrenaline were carried out as standard protocol."1.31Characteristics of histamine tachyphylaxis in rat uterine smooth muscle. ( Gil Marqués, M; Martínez-Mir, I; Morales-Olivas, FJ; Rubio-Gomis, E, 2002)
" Dose-response curves to bolus doses of norepinephrine were shifted markedly to the right by an alpha-1 selective concentration of prazosin (1 nM) and were shifted to the right with depression of maximum by infusions of clonidine (0."1.28Antagonism of norepinephrine by clonidine in the isolated rat mesenteric vascular bed. ( Fleming, WW; Kong, JQ; Taylor, DA, 1991)
"tizanidine was antagonized by co-administration of prazosin but not by yohimbine."1.28Myorelaxant effect after intrathecal injection of antispastic drugs in rats. ( Klockgether, T; Schwarz, M; Sontag, KH; Turski, L; Wüllner, U, 1989)
"Clonidine did not increase cGMP levels in vascular preparations with intact endothelia, in the presence or absence of LY83583."1.27Evidence that cGMP is the mediator of endothelium-dependent inhibition of contractile responses of rat arteries to alpha-adrenoceptor stimulation. ( Diamond, J; Harris, KH; MacLeod, KM; Ng, DD, 1987)
"Prazosin was 300 times more active than rauwolscine in inhibiting NA-induced contractions."1.27Comparison of the responses to drugs acting on adrenoreceptors and muscarinic receptors in human isolated corpus cavernosum and cavernous artery. ( Andersson, KE; Hedlund, H, 1985)

Research

Studies (42)

TimeframeStudies, this research(%)All Research%
pre-199022 (52.38)18.7374
1990's13 (30.95)18.2507
2000's3 (7.14)29.6817
2010's4 (9.52)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Vikhe, S1
Nirmal, S1
Taguchi, K1
Bessho, N1
Hasegawa, M1
Narimatsu, H1
Matsumoto, T1
Kobayashi, T1
Ishibashi-Shiraishi, I1
Shiraishi, S1
Fujita, S1
Ogawa, S1
Kaneko, M1
Suzuki, M1
Tanaka, T1
Wong, ES1
Man, RY1
Vanhoutte, PM1
Ng, KF1
Martínez-Mir, I1
Gil Marqués, M1
Morales-Olivas, FJ1
Rubio-Gomis, E1
Leclerc, G1
Rouot, B1
Schwartz, J1
Velly, J1
Wermuth, CG1
Oudart, N1
Sercombe, R1
Seylaz, J1
Weetman, DF1
Jahn, U1
Ismail, S1
Chadwick, MA1
Coates, J1
Lawson, K1
Turner, N1
Thiele, K1
Loiacono, RE1
Story, DF1
Wikberg, JE1
Cheng, HC1
Woodward, JK1
Goyal, RK1
Dave, KC1
Verma, SC1
Brutsaert, DL1
De Clerck, NM1
Sys, SU1
Friggi, A1
Bodard, H1
Hermann, C1
Kim, M1
Blanchard, EB1
Butelman, ER1
Woods, JH1
Kitani, K1
Machida, J1
Wada, Y1
Yoshida, M1
Ueda, S1
Wong, KK1
Arimitsu, M1
Mitsui-Saito, M1
Sato, K1
Ozaki, H1
Koga, Y1
Karaki, H1
Thumshirn, M1
Camilleri, M2
Choi, MG1
Zinsmeister, AR1
Iwanaga, S1
Shibata, O1
Tsuda, A1
Hashimoto, S1
Makita, T1
Cho, S1
Sumikawa, K1
Malcolm, A1
Kyselá, S1
Török, J1
Guenaneche, F1
Schuurkes, JA1
Lefebvre, RA2
Valencia, I1
Castillo, C1
Hong, E1
Kong, JQ1
Taylor, DA1
Fleming, WW1
Palmeri, A1
Wiesendanger, M1
Ayajiki, K1
Toda, N3
Zheng, XF1
Zhao, MH1
Lin, B1
Mao, LG1
Bian, RL1
Shibata, S1
Satake, N1
Hester, RK1
Ramagopal, MV2
Leighton, HJ2
Demirel, E1
Hindioglu, F1
Ercan, ZS1
Türker, RK1
Mattiasson, A1
Andersson, KE2
Sjögren, C1
Leff, AR1
Tallet, J1
Munoz, NM1
Shoulberg, N1
Bogaert, MG1
Lefebvre, R1
MacLeod, KM1
Ng, DD1
Harris, KH1
Diamond, J1
Klockgether, T1
Schwarz, M1
Wüllner, U1
Turski, L1
Sontag, KH1
Hedlund, H1
Bian, K1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Effectiveness of Onabotulinumtoxin A (Botox) in Pediatric Patients Experiencing Migraines: A Randomized Double Blinded Placebo Cross-over Study in the Pediatric Pain Population[NCT03055767]Phase 217 participants (Actual)Interventional2017-03-01Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

"Duration of Migraine

Open-Label Period" (NCT03055767)
Timeframe: Duration of migraine in hours during the open-label period (2 additional rounds of onabotulinumtoxinA) as compared to the cross-over period.

InterventionDuration of migraine in hours during the open-labe (hours)
Cross-Over PeriodMedian
"Open-Label Period Median

"Frequency of Migraines

Open-label Period" (NCT03055767)
Timeframe: The frequency of migraines during the open-label period (2 additional rounds of onabotulinumtoxinA) as compared to the cross-over period.

InterventionThe frequency of migraines during the open-label p (days)
"Open-Label Period Median

"Intensity of Migraines

Open-Label Period" (NCT03055767)
Timeframe: "Intensity of migraines during the the open-label period (2 additional rounds of onabotulinumtoxinA) as compared to the cross-over period.~Intensity based on 0-10 Pain Numeric Rating Score (NRS). The higher the score, the more intense the pain."

Intervention"Intensity of migraines during the the open-label (units on a scale)
Cross-Over PeriodMedian
"Open-Label Period Median

"Pediatric Migraine Disability Score (PedMIDAS)

Open-Label Period" (NCT03055767)
Timeframe: "The PedMIDAS the open-label period (2 additional rounds of onabotulinumtoxinA) as compared to the cross-over period.~The PedMIDAS consists of 6 questions: 3 addressing school attendance and functioning, and 3 evaluating participation in events outside of

Intervention"The PedMIDAS the open-label period (2 additional (score on a scale)
Cross-Over PeriodMedian
"Open-Label Period Median

Concomitant Headache Medications

Number of concomitant headache medications taken (NCT03055767)
Timeframe: Baseline (4 weeks) and 12 weeks post each, respective intervention

Interventionnumber taken (Median)
"Baseline Period 3
Botox Period1
Placebo Period2

Difficulty Sleeping

Subject reported having difficulty sleeping (NCT03055767)
Timeframe: Baseline (4 weeks) and 12 weeks post each, respective intervention

InterventionParticipants (Count of Participants)
"Baseline Period 12
Botox Period5
Placebo Period11

Duration of Benefit

The duration of benefit in weeks (NCT03055767)
Timeframe: Baseline (4 weeks) and 12 weeks post each, respective intervention

Interventionweeks (Median)
Botox Period4
Placebo Period0

Emergency Department (ED) Visits

Subject visited an Emergency Department (NCT03055767)
Timeframe: Baseline (4 weeks) and 12 weeks post each, respective intervention

InterventionParticipants (Count of Participants)
"Baseline Period 8
Botox Period2
Placebo Period3

Frequency of Migraines

The frequency of migraines in days. (NCT03055767)
Timeframe: Baseline (4 weeks) and 12 weeks post each, respective intervention

Interventiondays (Median)
"Baseline Period 28
Botox Period20
Placebo Period28

Functionality Improvement

"Improvement of functionality as determined by their Pediatric Migraine Disability Score (PedMIDAS). The PedMIDAS consists of 6 questions: 3 addressing school attendance and functioning, and 3 evaluating participation in events outside of school. The questionnaire is based on the patient's recall of the previous 3 months.~The questionnaire produces a raw score (0-10, 11-30, 31-50, >50) corresponding to a disability grade with increasing severity (little to non, mild, moderate, and severe) which was coded (1, 2, 3, and 4)." (NCT03055767)
Timeframe: Baseline (4 weeks) and 12 weeks post each, respective intervention

Interventionscore on a scale (Median)
Botox Period1
Placebo Period0

Home School

Subject is home schooled full-time. (NCT03055767)
Timeframe: Baseline (4 weeks) and 12 weeks post, respective intervention

InterventionParticipants (Count of Participants)
"Baseline Period 2
Botox Period2
Placebo Period2

Hospital Admissions

Admission to hospital (NCT03055767)
Timeframe: Baseline (4 weeks) and 12 weeks post each, respective intervention

InterventionParticipants (Count of Participants)
"Baseline Period 8
Botox Period0
Placebo Period2

Intensity of Migraines

Median intensity of migraines based on 0-10 Pain Numeric Rating Score (NRS). The higher the score, the more intense the pain. (NCT03055767)
Timeframe: Baseline (4 weeks) and 12 weeks post each, respective intervention

Interventionunits on a scale (Median)
"Baseline Period 8
Botox Period5
Placebo Period7

Migraine Duration, in Hours

Duration of migraines in hours. (NCT03055767)
Timeframe: Baseline (4 weeks) and 12 weeks post each, respective intervention

Interventionhours (Median)
"Baseline Period 24
Botox Period10
Placebo Period24

Pediatric Migraine Disability Score (PedMIDAS)

"Pediatric Migraine Disability Score consists of 6 questions: 3 addressing school attendance and functioning, and 3 evaluating participation in events outside of school. The questionnaire is based on the patient's recall of the previous 3 months.~The questionnaire produces a raw score (0-10, 11-30, 31-50, >50) corresponding to a disability grade with increasing severity (little to non, mild, moderate, and severe) which was coded (1, 2, 3, and 4)." (NCT03055767)
Timeframe: Baseline (4 weeks) and 12 weeks post each, respective intervention

Interventionscore on a scale (Median)
"Baseline Period 4
Botox Period3
Placebo Period4

School Plan Enrollment

Subject is enrolled in a school plan such as IEP, 504 plan, or similar modified school schedule. (NCT03055767)
Timeframe: Baseline (4 weeks) and 12 weeks post each, respective intervention

InterventionParticipants (Count of Participants)
"Baseline Period 11
Botox Period10
Placebo Period10

Reviews

2 reviews available for clonidine and Muscle Relaxation

ArticleYear
Sgd 101/75: a sympathomimetic that can be used to identify a new subtype of alpha-adrenoceptor, the alpha 1s-adrenoceptor.
    Methods and findings in experimental and clinical pharmacology, 1983, Volume: 5, Issue:7

    Topics: Adrenergic alpha-Agonists; Animals; Clonidine; Electric Stimulation; Hemodynamics; Humans; Muscle Co

1983
Behavioral and prophylactic pharmacological intervention studies of pediatric migraine: an exploratory meta-analysis.
    Pain, 1995, Volume: 60, Issue:3

    Topics: Behavioral Medicine; Biofeedback, Psychology; Child; Clonidine; Dopamine Agents; Humans; Migraine Di

1995

Trials

1 trial available for clonidine and Muscle Relaxation

ArticleYear
Modulation of gastric sensory and motor functions by nitrergic and alpha2-adrenergic agents in humans.
    Gastroenterology, 1999, Volume: 116, Issue:3

    Topics: Administration, Oral; Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-Agonists; Adult; Blood

1999

Other Studies

39 other studies available for clonidine and Muscle Relaxation

ArticleYear
Antiallergic and antihistaminic actions of Ceasalpinia bonducella seeds: Possible role in treatment of asthma.
    Journal of ethnopharmacology, 2018, Apr-24, Volume: 216

    Topics: Acetates; Animals; Anti-Allergic Agents; Anti-Asthmatic Agents; Caesalpinia; Catalepsy; Cell Degranu

2018
Co-treatment with clonidine and a GRK2 inhibitor prevented rebound hypertension and endothelial dysfunction after withdrawal in diabetes.
    Hypertension research : official journal of the Japanese Society of Hypertension, 2018, Volume: 41, Issue:4

    Topics: Animals; Antihypertensive Agents; Aorta, Thoracic; Blood Pressure; Clonidine; Diabetes Mellitus, Exp

2018
L-Arginine L-Glutamate Enhances Gastric Motor Function in Rats and Dogs and Improves Delayed Gastric Emptying in Dogs.
    The Journal of pharmacology and experimental therapeutics, 2016, Volume: 359, Issue:2

    Topics: Administration, Oral; Animals; Arginine; Clonidine; Dogs; Female; Gastric Emptying; Glutamic Acid; M

2016
Dexmedetomidine induces both relaxations and contractions, via different {alpha}2-adrenoceptor subtypes, in the isolated mesenteric artery and aorta of the rat.
    The Journal of pharmacology and experimental therapeutics, 2010, Volume: 335, Issue:3

    Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adrenergic alpha-1 Receptor Anta

2010
Characteristics of histamine tachyphylaxis in rat uterine smooth muscle.
    Inflammation research : official journal of the European Histamine Research Society ... [et al.], 2002, Volume: 51, Issue:12

    Topics: Adrenergic alpha-Agonists; Animals; Clonidine; Cyclic AMP; Dimaprit; Dose-Response Relationship, Dru

2002
Studies on some para-substituted clonidine derivatives that exhibit an alpha-adrenoceptor stimulant activity.
    British journal of pharmacology, 1980, Volume: 71, Issue:1

    Topics: Adrenergic alpha-Agonists; Animals; Aorta; Blood Pressure; Clonidine; In Vitro Techniques; Injection

1980
Relaxation of rabbit cerebral arteries in vitro by clonidine. Evidence of H2-receptor mediation.
    Archives internationales de pharmacodynamie et de therapie, 1983, Volume: 265, Issue:2

    Topics: Adrenergic alpha-Antagonists; Animals; Cerebral Arteries; Clonidine; Histamine H2 Antagonists; Muscl

1983
Acetylcholine-induced inhibition of responses to field stimulation in rabbit pulmonary artery is unaffected by endothelium removal.
    The Journal of pharmacy and pharmacology, 1984, Volume: 36, Issue:4

    Topics: Acetylcholine; Animals; Clonidine; Electric Stimulation; Endothelium; Female; In Vitro Techniques; I

1984
Reversal of alpha 1-receptor mediated relaxation in intestinal smooth muscle.
    Acta physiologica Scandinavica, 1981, Volume: 111, Issue:4

    Topics: Animals; Clonidine; Electrolytes; Female; Guinea Pigs; Intestines; Male; Muscle Contraction; Muscle

1981
Mouse uterine muscle as a model for studying beta 2-adrenoreceptor mediated relaxation.
    Journal of autonomic pharmacology, 1984, Volume: 4, Issue:1

    Topics: Animals; Clonidine; Epinephrine; Estrus; Female; In Vitro Techniques; Isoproterenol; Mice; Models, B

1984
The inhibitory effect of clonidine on the oestrogen-primed rat isolated uterus.
    Journal of autonomic pharmacology, 1983, Volume: 3, Issue:3

    Topics: Animals; Clonidine; Dose-Response Relationship, Drug; Estrogens; Female; In Vitro Techniques; Muscle

1983
Effects of alinidine on myocardial contraction and relaxation.
    Archives internationales de pharmacodynamie et de therapie, 1982, Volume: 259, Issue:2

    Topics: Animals; Cardiovascular Agents; Cats; Clonidine; In Vitro Techniques; Muscle Relaxation; Myocardial

1982
Effects of clonidine on aortic elastic modulus and aortic stress in anesthetized rabbits.
    Experientia, 1981, Jul-15, Volume: 37, Issue:7

    Topics: Animals; Aorta; Blood Pressure; Clonidine; Elasticity; Muscle Contraction; Muscle Relaxation; Rabbit

1981
Effects of clonidine, dexmedetomidine and xylazine on thermal antinociception in rhesus monkeys.
    The Journal of pharmacology and experimental therapeutics, 1993, Volume: 264, Issue:2

    Topics: Adrenergic alpha-Agonists; Analgesics; Animals; Azocines; Clonidine; Dioxanes; Dose-Response Relatio

1993
Effect of cyclosporin A on isolated rabbit bladder and urethral smooth muscle.
    International journal of urology : official journal of the Japanese Urological Association, 1996, Volume: 3, Issue:2

    Topics: Acetylcholine; Animals; Clonidine; Cyclosporine; Dose-Response Relationship, Drug; Female; In Vitro

1996
Drug induced contraction and relaxation in mouse isolated aorta.
    Artery, 1997, Volume: 22, Issue:4

    Topics: 1-Methyl-3-isobutylxanthine; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Aorta

1997
Mechanism of relaxant effect of clonidine in isolated bovine tracheal smooth muscle.
    The Journal of pharmacology and experimental therapeutics, 1998, Volume: 286, Issue:2

    Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Calcium; Cattle; Clonidine; Cyclic

1998
The role of alpha1-adrenoceptors in the clonidine-induced contraction and relaxation of rat aorta.
    Research communications in molecular pathology and pharmacology, 1998, Volume: 102, Issue:2

    Topics: Adrenergic alpha-1 Receptor Agonists; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Anima

1998
Coloanal motor coordination in association with high-amplitude colonic contractions after pharmacological stimulation.
    The American journal of gastroenterology, 2000, Volume: 95, Issue:3

    Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Adult; Anal Canal; Clonidine; Colon; Defeca

2000
Contemporary activation of different endothelial receptors accounts for a reserve mechanism of nitric oxide-mediated relaxation.
    Physiological research, 2000, Volume: 49, Issue:1

    Topics: Acetylcholine; Adenosine; Adrenergic alpha-Agonists; Animals; Clonidine; Endothelium, Vascular; Hist

2000
Influence of fenoldopam and quinpirole in the guinea-pig stomach.
    Journal of autonomic pharmacology, 1991, Volume: 11, Issue:4

    Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Clonidine; Dopamine; Dopamine A

1991
Contractile and relaxant effects of alpha-adrenergic agonists on rat aorta.
    Proceedings of the Western Pharmacology Society, 1991, Volume: 34

    Topics: Adrenergic alpha-Agonists; Animals; Aorta, Thoracic; Clonidine; Endothelium, Vascular; In Vitro Tech

1991
Antagonism of norepinephrine by clonidine in the isolated rat mesenteric vascular bed.
    The Journal of pharmacology and experimental therapeutics, 1991, Volume: 259, Issue:2

    Topics: Acetylcholine; Animals; Clonidine; Dose-Response Relationship, Drug; Endothelium, Vascular; Male; Mu

1991
Concomitant depression of locus coeruleus neurons and of flexor reflexes by an alpha 2-adrenergic agonist in rats: a possible mechanism for an alpha 2-mediated muscle relaxation.
    Neuroscience, 1990, Volume: 34, Issue:1

    Topics: Adrenergic alpha-Agonists; Animals; Clonidine; Female; Locus Coeruleus; Male; Muscle Contraction; Mu

1990
Isolated bovine cerebral arteries from rostral and caudal regions: distinct responses to adrenoceptor agonists.
    European journal of pharmacology, 1990, Dec-04, Volume: 191, Issue:3

    Topics: Adrenergic alpha-Agonists; Adrenergic beta-Agonists; Animals; Basilar Artery; Carotid Arteries; Catt

1990
[Effects of clonidine and norepinephrine on rabbit pulmonary artery strips with or without endothelium].
    Zhongguo yao li xue bao = Acta pharmacologica Sinica, 1990, Volume: 11, Issue:2

    Topics: Animals; Clonidine; Endothelium, Vascular; In Vitro Techniques; Muscle Relaxation; Muscle, Smooth, V

1990
Differential inhibitory effects of nitroglycerin on contractile responses to the alpha-adrenoceptor agonists, methoxamine and clonidine, in rabbit aorta.
    Journal of cardiovascular pharmacology, 1989, Volume: 13, Issue:2

    Topics: Adrenergic alpha-Agonists; Animals; Calcium; Calcium Radioisotopes; Clonidine; Egtazic Acid; In Vitr

1989
Analysis of the presence of postjunctional alpha-2 adrenoceptors in the rat anococcygeus muscle.
    The Journal of pharmacology and experimental therapeutics, 1989, Volume: 250, Issue:2

    Topics: Animals; Clonidine; Dioxanes; Electric Stimulation; Idazoxan; In Vitro Techniques; Male; Muscle Cont

1989
Endothelium modulates the effects of alpha-adrenoceptor agonists in vascular smooth muscle.
    General pharmacology, 1989, Volume: 20, Issue:1

    Topics: Acetylcholine; Adrenergic alpha-Agonists; Animals; Aorta, Thoracic; Arteries; Clonidine; Endothelium

1989
Effects of NG-monomethyl-L-arginine on field stimulation-induced decreases in cytosolic Ca2+ levels and relaxation in the rat anococcygeus muscle.
    European journal of pharmacology, 1989, Dec-19, Volume: 174, Issue:2-3

    Topics: Animals; Arginine; Calcium; Clonidine; Cytosol; Electric Stimulation; In Vitro Techniques; Male; Mus

1989
Contractant and relaxant properties of the female rabbit urethral submucosa.
    The Journal of urology, 1985, Volume: 133, Issue:2

    Topics: Adrenergic alpha-Antagonists; Animals; Clonidine; Electric Stimulation; Female; In Vitro Techniques;

1985
Physiological antagonism caused by adrenergic stimulation of canine tracheal muscle.
    Journal of applied physiology (Bethesda, Md. : 1985), 1986, Volume: 60, Issue:1

    Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Animals; Clonidine; Dogs; Female; Male; M

1986
Neither morphine nor clonidine influence the non-adrenergic, non-cholinergic inhibitory response in the rat gastric fundus.
    The Journal of pharmacy and pharmacology, 1986, Volume: 38, Issue:8

    Topics: Animals; Clonidine; Electric Stimulation; Female; Gastric Fundus; In Vitro Techniques; Morphine; Mus

1986
[In vitro study of the non-adrenergic non-cholinergic innervation of the rat and cat stomach].
    Verhandelingen - Koninklijke Academie voor Geneeskunde van Belgie, 1986, Volume: 48, Issue:5

    Topics: Animals; Cats; Clonidine; Electric Stimulation; Enkephalins; Female; Gastric Fundus; In Vitro Techni

1986
Evidence that cGMP is the mediator of endothelium-dependent inhibition of contractile responses of rat arteries to alpha-adrenoceptor stimulation.
    Molecular pharmacology, 1987, Volume: 32, Issue:1

    Topics: Acetylcholine; Adrenergic alpha-Agonists; Aminoquinolines; Animals; Aorta; Clonidine; Cyclic GMP; En

1987
Responsiveness of isolated monkey coronary arteries contracted with alpha 1- and alpha 2-adrenoceptor agonists to diltiazem.
    European journal of pharmacology, 1988, Mar-01, Volume: 147, Issue:2

    Topics: Adrenergic alpha-Agonists; Animals; Clonidine; Coronary Vessels; Diltiazem; Dinoprost; Female; In Vi

1988
Myorelaxant effect after intrathecal injection of antispastic drugs in rats.
    Neuroscience letters, 1989, Feb-13, Volume: 97, Issue:1-2

    Topics: Animals; Baclofen; Clonidine; Dose-Response Relationship, Drug; Female; H-Reflex; Injections, Spinal

1989
Comparison of the responses to drugs acting on adrenoreceptors and muscarinic receptors in human isolated corpus cavernosum and cavernous artery.
    Journal of autonomic pharmacology, 1985, Volume: 5, Issue:1

    Topics: Acetylcholine; Aged; Carbachol; Clonidine; Electric Stimulation; Ethanolamines; Humans; In Vitro Tec

1985
Effects of sophoramine, an alkaloid from Sophora alopecuroides on isolated dog blood vessels.
    Journal of ethnopharmacology, 1988, Volume: 24, Issue:2-3

    Topics: Adrenergic Fibers; Alkaloids; Animals; Cerebral Arteries; Clonidine; Coronary Vessels; Dinoprost; Do

1988