clonidine has been researched along with Muscle Relaxation in 42 studies
Clonidine: An imidazoline sympatholytic agent that stimulates ALPHA-2 ADRENERGIC RECEPTORS and central IMIDAZOLINE RECEPTORS. It is commonly used in the management of HYPERTENSION.
clonidine (amino form) : A clonidine that is 4,5-dihydro-1H-imidazol-2-amine in which one of the amino hydrogens is replaced by a 2,6-dichlorophenyl group.
Muscle Relaxation: That phase of a muscle twitch during which a muscle returns to a resting position.
Excerpt | Relevance | Reference |
---|---|---|
" effect of test drug on clonidine and haloperidol induced catalepsy, milk-induced leukocytosis and eosinophilia, mast cell stabilizing activity in mice and studies on smooth muscle preparation of guinea pig ileum (in-vitro)." | 3.88 | Antiallergic and antihistaminic actions of Ceasalpinia bonducella seeds: Possible role in treatment of asthma. ( Nirmal, S; Vikhe, S, 2018) |
"In phenoxybenzamine-pretreated preparations, Sgd 101/75 (400 microM) did not antagonise NA (maximal effect and EC50 values not changed significantly), so it was concluded that Sgd 101/75 and NA interact with different alpha 1-adrenoceptor subtypes in this tissue." | 2.36 | Sgd 101/75: a sympathomimetic that can be used to identify a new subtype of alpha-adrenoceptor, the alpha 1s-adrenoceptor. ( Chadwick, MA; Coates, J; Ismail, S; Jahn, U; Lawson, K; Thiele, K; Turner, N; Weetman, DF, 1983) |
" Dose-response curves for adrenaline were carried out as standard protocol." | 1.31 | Characteristics of histamine tachyphylaxis in rat uterine smooth muscle. ( Gil Marqués, M; Martínez-Mir, I; Morales-Olivas, FJ; Rubio-Gomis, E, 2002) |
" Dose-response curves to bolus doses of norepinephrine were shifted markedly to the right by an alpha-1 selective concentration of prazosin (1 nM) and were shifted to the right with depression of maximum by infusions of clonidine (0." | 1.28 | Antagonism of norepinephrine by clonidine in the isolated rat mesenteric vascular bed. ( Fleming, WW; Kong, JQ; Taylor, DA, 1991) |
"tizanidine was antagonized by co-administration of prazosin but not by yohimbine." | 1.28 | Myorelaxant effect after intrathecal injection of antispastic drugs in rats. ( Klockgether, T; Schwarz, M; Sontag, KH; Turski, L; Wüllner, U, 1989) |
"Clonidine did not increase cGMP levels in vascular preparations with intact endothelia, in the presence or absence of LY83583." | 1.27 | Evidence that cGMP is the mediator of endothelium-dependent inhibition of contractile responses of rat arteries to alpha-adrenoceptor stimulation. ( Diamond, J; Harris, KH; MacLeod, KM; Ng, DD, 1987) |
"Prazosin was 300 times more active than rauwolscine in inhibiting NA-induced contractions." | 1.27 | Comparison of the responses to drugs acting on adrenoreceptors and muscarinic receptors in human isolated corpus cavernosum and cavernous artery. ( Andersson, KE; Hedlund, H, 1985) |
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 22 (52.38) | 18.7374 |
1990's | 13 (30.95) | 18.2507 |
2000's | 3 (7.14) | 29.6817 |
2010's | 4 (9.52) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
Authors | Studies |
---|---|
Vikhe, S | 1 |
Nirmal, S | 1 |
Taguchi, K | 1 |
Bessho, N | 1 |
Hasegawa, M | 1 |
Narimatsu, H | 1 |
Matsumoto, T | 1 |
Kobayashi, T | 1 |
Ishibashi-Shiraishi, I | 1 |
Shiraishi, S | 1 |
Fujita, S | 1 |
Ogawa, S | 1 |
Kaneko, M | 1 |
Suzuki, M | 1 |
Tanaka, T | 1 |
Wong, ES | 1 |
Man, RY | 1 |
Vanhoutte, PM | 1 |
Ng, KF | 1 |
Martínez-Mir, I | 1 |
Gil Marqués, M | 1 |
Morales-Olivas, FJ | 1 |
Rubio-Gomis, E | 1 |
Leclerc, G | 1 |
Rouot, B | 1 |
Schwartz, J | 1 |
Velly, J | 1 |
Wermuth, CG | 1 |
Oudart, N | 1 |
Sercombe, R | 1 |
Seylaz, J | 1 |
Weetman, DF | 1 |
Jahn, U | 1 |
Ismail, S | 1 |
Chadwick, MA | 1 |
Coates, J | 1 |
Lawson, K | 1 |
Turner, N | 1 |
Thiele, K | 1 |
Loiacono, RE | 1 |
Story, DF | 1 |
Wikberg, JE | 1 |
Cheng, HC | 1 |
Woodward, JK | 1 |
Goyal, RK | 1 |
Dave, KC | 1 |
Verma, SC | 1 |
Brutsaert, DL | 1 |
De Clerck, NM | 1 |
Sys, SU | 1 |
Friggi, A | 1 |
Bodard, H | 1 |
Hermann, C | 1 |
Kim, M | 1 |
Blanchard, EB | 1 |
Butelman, ER | 1 |
Woods, JH | 1 |
Kitani, K | 1 |
Machida, J | 1 |
Wada, Y | 1 |
Yoshida, M | 1 |
Ueda, S | 1 |
Wong, KK | 1 |
Arimitsu, M | 1 |
Mitsui-Saito, M | 1 |
Sato, K | 1 |
Ozaki, H | 1 |
Koga, Y | 1 |
Karaki, H | 1 |
Thumshirn, M | 1 |
Camilleri, M | 2 |
Choi, MG | 1 |
Zinsmeister, AR | 1 |
Iwanaga, S | 1 |
Shibata, O | 1 |
Tsuda, A | 1 |
Hashimoto, S | 1 |
Makita, T | 1 |
Cho, S | 1 |
Sumikawa, K | 1 |
Malcolm, A | 1 |
Kyselá, S | 1 |
Török, J | 1 |
Guenaneche, F | 1 |
Schuurkes, JA | 1 |
Lefebvre, RA | 2 |
Valencia, I | 1 |
Castillo, C | 1 |
Hong, E | 1 |
Kong, JQ | 1 |
Taylor, DA | 1 |
Fleming, WW | 1 |
Palmeri, A | 1 |
Wiesendanger, M | 1 |
Ayajiki, K | 1 |
Toda, N | 3 |
Zheng, XF | 1 |
Zhao, MH | 1 |
Lin, B | 1 |
Mao, LG | 1 |
Bian, RL | 1 |
Shibata, S | 1 |
Satake, N | 1 |
Hester, RK | 1 |
Ramagopal, MV | 2 |
Leighton, HJ | 2 |
Demirel, E | 1 |
Hindioglu, F | 1 |
Ercan, ZS | 1 |
Türker, RK | 1 |
Mattiasson, A | 1 |
Andersson, KE | 2 |
Sjögren, C | 1 |
Leff, AR | 1 |
Tallet, J | 1 |
Munoz, NM | 1 |
Shoulberg, N | 1 |
Bogaert, MG | 1 |
Lefebvre, R | 1 |
MacLeod, KM | 1 |
Ng, DD | 1 |
Harris, KH | 1 |
Diamond, J | 1 |
Klockgether, T | 1 |
Schwarz, M | 1 |
Wüllner, U | 1 |
Turski, L | 1 |
Sontag, KH | 1 |
Hedlund, H | 1 |
Bian, K | 1 |
Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
---|---|---|---|---|---|---|---|
Effectiveness of Onabotulinumtoxin A (Botox) in Pediatric Patients Experiencing Migraines: A Randomized Double Blinded Placebo Cross-over Study in the Pediatric Pain Population[NCT03055767] | Phase 2 | 17 participants (Actual) | Interventional | 2017-03-01 | Completed | ||
[information is prepared from clinicaltrials.gov, extracted Sep-2024] |
Open-Label Period" (NCT03055767)
Timeframe: Duration of migraine in hours during the open-label period (2 additional rounds of onabotulinumtoxinA) as compared to the cross-over period.
Intervention | Duration of migraine in hours during the open-labe (hours) |
---|---|
Cross-Over Period | Median |
"Open-Label Period | Median |
Open-label Period" (NCT03055767)
Timeframe: The frequency of migraines during the open-label period (2 additional rounds of onabotulinumtoxinA) as compared to the cross-over period.
Intervention | The frequency of migraines during the open-label p (days) |
---|---|
"Open-Label Period | Median |
Open-Label Period" (NCT03055767)
Timeframe: "Intensity of migraines during the the open-label period (2 additional rounds of onabotulinumtoxinA) as compared to the cross-over period.~Intensity based on 0-10 Pain Numeric Rating Score (NRS). The higher the score, the more intense the pain."
Intervention | "Intensity of migraines during the the open-label (units on a scale) |
---|---|
Cross-Over Period | Median |
"Open-Label Period | Median |
Open-Label Period" (NCT03055767)
Timeframe: "The PedMIDAS the open-label period (2 additional rounds of onabotulinumtoxinA) as compared to the cross-over period.~The PedMIDAS consists of 6 questions: 3 addressing school attendance and functioning, and 3 evaluating participation in events outside of
Intervention | "The PedMIDAS the open-label period (2 additional (score on a scale) |
---|---|
Cross-Over Period | Median |
"Open-Label Period | Median |
Number of concomitant headache medications taken (NCT03055767)
Timeframe: Baseline (4 weeks) and 12 weeks post each, respective intervention
Intervention | number taken (Median) |
---|---|
"Baseline Period | 3 |
Botox Period | 1 |
Placebo Period | 2 |
Subject reported having difficulty sleeping (NCT03055767)
Timeframe: Baseline (4 weeks) and 12 weeks post each, respective intervention
Intervention | Participants (Count of Participants) |
---|---|
"Baseline Period | 12 |
Botox Period | 5 |
Placebo Period | 11 |
The duration of benefit in weeks (NCT03055767)
Timeframe: Baseline (4 weeks) and 12 weeks post each, respective intervention
Intervention | weeks (Median) |
---|---|
Botox Period | 4 |
Placebo Period | 0 |
Subject visited an Emergency Department (NCT03055767)
Timeframe: Baseline (4 weeks) and 12 weeks post each, respective intervention
Intervention | Participants (Count of Participants) |
---|---|
"Baseline Period | 8 |
Botox Period | 2 |
Placebo Period | 3 |
The frequency of migraines in days. (NCT03055767)
Timeframe: Baseline (4 weeks) and 12 weeks post each, respective intervention
Intervention | days (Median) |
---|---|
"Baseline Period | 28 |
Botox Period | 20 |
Placebo Period | 28 |
"Improvement of functionality as determined by their Pediatric Migraine Disability Score (PedMIDAS). The PedMIDAS consists of 6 questions: 3 addressing school attendance and functioning, and 3 evaluating participation in events outside of school. The questionnaire is based on the patient's recall of the previous 3 months.~The questionnaire produces a raw score (0-10, 11-30, 31-50, >50) corresponding to a disability grade with increasing severity (little to non, mild, moderate, and severe) which was coded (1, 2, 3, and 4)." (NCT03055767)
Timeframe: Baseline (4 weeks) and 12 weeks post each, respective intervention
Intervention | score on a scale (Median) |
---|---|
Botox Period | 1 |
Placebo Period | 0 |
Subject is home schooled full-time. (NCT03055767)
Timeframe: Baseline (4 weeks) and 12 weeks post, respective intervention
Intervention | Participants (Count of Participants) |
---|---|
"Baseline Period | 2 |
Botox Period | 2 |
Placebo Period | 2 |
Admission to hospital (NCT03055767)
Timeframe: Baseline (4 weeks) and 12 weeks post each, respective intervention
Intervention | Participants (Count of Participants) |
---|---|
"Baseline Period | 8 |
Botox Period | 0 |
Placebo Period | 2 |
Median intensity of migraines based on 0-10 Pain Numeric Rating Score (NRS). The higher the score, the more intense the pain. (NCT03055767)
Timeframe: Baseline (4 weeks) and 12 weeks post each, respective intervention
Intervention | units on a scale (Median) |
---|---|
"Baseline Period | 8 |
Botox Period | 5 |
Placebo Period | 7 |
Duration of migraines in hours. (NCT03055767)
Timeframe: Baseline (4 weeks) and 12 weeks post each, respective intervention
Intervention | hours (Median) |
---|---|
"Baseline Period | 24 |
Botox Period | 10 |
Placebo Period | 24 |
"Pediatric Migraine Disability Score consists of 6 questions: 3 addressing school attendance and functioning, and 3 evaluating participation in events outside of school. The questionnaire is based on the patient's recall of the previous 3 months.~The questionnaire produces a raw score (0-10, 11-30, 31-50, >50) corresponding to a disability grade with increasing severity (little to non, mild, moderate, and severe) which was coded (1, 2, 3, and 4)." (NCT03055767)
Timeframe: Baseline (4 weeks) and 12 weeks post each, respective intervention
Intervention | score on a scale (Median) |
---|---|
"Baseline Period | 4 |
Botox Period | 3 |
Placebo Period | 4 |
Subject is enrolled in a school plan such as IEP, 504 plan, or similar modified school schedule. (NCT03055767)
Timeframe: Baseline (4 weeks) and 12 weeks post each, respective intervention
Intervention | Participants (Count of Participants) |
---|---|
"Baseline Period | 11 |
Botox Period | 10 |
Placebo Period | 10 |
2 reviews available for clonidine and Muscle Relaxation
Article | Year |
---|---|
Sgd 101/75: a sympathomimetic that can be used to identify a new subtype of alpha-adrenoceptor, the alpha 1s-adrenoceptor.
Topics: Adrenergic alpha-Agonists; Animals; Clonidine; Electric Stimulation; Hemodynamics; Humans; Muscle Co | 1983 |
Behavioral and prophylactic pharmacological intervention studies of pediatric migraine: an exploratory meta-analysis.
Topics: Behavioral Medicine; Biofeedback, Psychology; Child; Clonidine; Dopamine Agents; Humans; Migraine Di | 1995 |
1 trial available for clonidine and Muscle Relaxation
Article | Year |
---|---|
Modulation of gastric sensory and motor functions by nitrergic and alpha2-adrenergic agents in humans.
Topics: Administration, Oral; Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-Agonists; Adult; Blood | 1999 |
39 other studies available for clonidine and Muscle Relaxation
Article | Year |
---|---|
Antiallergic and antihistaminic actions of Ceasalpinia bonducella seeds: Possible role in treatment of asthma.
Topics: Acetates; Animals; Anti-Allergic Agents; Anti-Asthmatic Agents; Caesalpinia; Catalepsy; Cell Degranu | 2018 |
Co-treatment with clonidine and a GRK2 inhibitor prevented rebound hypertension and endothelial dysfunction after withdrawal in diabetes.
Topics: Animals; Antihypertensive Agents; Aorta, Thoracic; Blood Pressure; Clonidine; Diabetes Mellitus, Exp | 2018 |
L-Arginine L-Glutamate Enhances Gastric Motor Function in Rats and Dogs and Improves Delayed Gastric Emptying in Dogs.
Topics: Administration, Oral; Animals; Arginine; Clonidine; Dogs; Female; Gastric Emptying; Glutamic Acid; M | 2016 |
Dexmedetomidine induces both relaxations and contractions, via different {alpha}2-adrenoceptor subtypes, in the isolated mesenteric artery and aorta of the rat.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adrenergic alpha-1 Receptor Anta | 2010 |
Characteristics of histamine tachyphylaxis in rat uterine smooth muscle.
Topics: Adrenergic alpha-Agonists; Animals; Clonidine; Cyclic AMP; Dimaprit; Dose-Response Relationship, Dru | 2002 |
Studies on some para-substituted clonidine derivatives that exhibit an alpha-adrenoceptor stimulant activity.
Topics: Adrenergic alpha-Agonists; Animals; Aorta; Blood Pressure; Clonidine; In Vitro Techniques; Injection | 1980 |
Relaxation of rabbit cerebral arteries in vitro by clonidine. Evidence of H2-receptor mediation.
Topics: Adrenergic alpha-Antagonists; Animals; Cerebral Arteries; Clonidine; Histamine H2 Antagonists; Muscl | 1983 |
Acetylcholine-induced inhibition of responses to field stimulation in rabbit pulmonary artery is unaffected by endothelium removal.
Topics: Acetylcholine; Animals; Clonidine; Electric Stimulation; Endothelium; Female; In Vitro Techniques; I | 1984 |
Reversal of alpha 1-receptor mediated relaxation in intestinal smooth muscle.
Topics: Animals; Clonidine; Electrolytes; Female; Guinea Pigs; Intestines; Male; Muscle Contraction; Muscle | 1981 |
Mouse uterine muscle as a model for studying beta 2-adrenoreceptor mediated relaxation.
Topics: Animals; Clonidine; Epinephrine; Estrus; Female; In Vitro Techniques; Isoproterenol; Mice; Models, B | 1984 |
The inhibitory effect of clonidine on the oestrogen-primed rat isolated uterus.
Topics: Animals; Clonidine; Dose-Response Relationship, Drug; Estrogens; Female; In Vitro Techniques; Muscle | 1983 |
Effects of alinidine on myocardial contraction and relaxation.
Topics: Animals; Cardiovascular Agents; Cats; Clonidine; In Vitro Techniques; Muscle Relaxation; Myocardial | 1982 |
Effects of clonidine on aortic elastic modulus and aortic stress in anesthetized rabbits.
Topics: Animals; Aorta; Blood Pressure; Clonidine; Elasticity; Muscle Contraction; Muscle Relaxation; Rabbit | 1981 |
Effects of clonidine, dexmedetomidine and xylazine on thermal antinociception in rhesus monkeys.
Topics: Adrenergic alpha-Agonists; Analgesics; Animals; Azocines; Clonidine; Dioxanes; Dose-Response Relatio | 1993 |
Effect of cyclosporin A on isolated rabbit bladder and urethral smooth muscle.
Topics: Acetylcholine; Animals; Clonidine; Cyclosporine; Dose-Response Relationship, Drug; Female; In Vitro | 1996 |
Drug induced contraction and relaxation in mouse isolated aorta.
Topics: 1-Methyl-3-isobutylxanthine; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Aorta | 1997 |
Mechanism of relaxant effect of clonidine in isolated bovine tracheal smooth muscle.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Calcium; Cattle; Clonidine; Cyclic | 1998 |
The role of alpha1-adrenoceptors in the clonidine-induced contraction and relaxation of rat aorta.
Topics: Adrenergic alpha-1 Receptor Agonists; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Anima | 1998 |
Coloanal motor coordination in association with high-amplitude colonic contractions after pharmacological stimulation.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Adult; Anal Canal; Clonidine; Colon; Defeca | 2000 |
Contemporary activation of different endothelial receptors accounts for a reserve mechanism of nitric oxide-mediated relaxation.
Topics: Acetylcholine; Adenosine; Adrenergic alpha-Agonists; Animals; Clonidine; Endothelium, Vascular; Hist | 2000 |
Influence of fenoldopam and quinpirole in the guinea-pig stomach.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Clonidine; Dopamine; Dopamine A | 1991 |
Contractile and relaxant effects of alpha-adrenergic agonists on rat aorta.
Topics: Adrenergic alpha-Agonists; Animals; Aorta, Thoracic; Clonidine; Endothelium, Vascular; In Vitro Tech | 1991 |
Antagonism of norepinephrine by clonidine in the isolated rat mesenteric vascular bed.
Topics: Acetylcholine; Animals; Clonidine; Dose-Response Relationship, Drug; Endothelium, Vascular; Male; Mu | 1991 |
Concomitant depression of locus coeruleus neurons and of flexor reflexes by an alpha 2-adrenergic agonist in rats: a possible mechanism for an alpha 2-mediated muscle relaxation.
Topics: Adrenergic alpha-Agonists; Animals; Clonidine; Female; Locus Coeruleus; Male; Muscle Contraction; Mu | 1990 |
Isolated bovine cerebral arteries from rostral and caudal regions: distinct responses to adrenoceptor agonists.
Topics: Adrenergic alpha-Agonists; Adrenergic beta-Agonists; Animals; Basilar Artery; Carotid Arteries; Catt | 1990 |
[Effects of clonidine and norepinephrine on rabbit pulmonary artery strips with or without endothelium].
Topics: Animals; Clonidine; Endothelium, Vascular; In Vitro Techniques; Muscle Relaxation; Muscle, Smooth, V | 1990 |
Differential inhibitory effects of nitroglycerin on contractile responses to the alpha-adrenoceptor agonists, methoxamine and clonidine, in rabbit aorta.
Topics: Adrenergic alpha-Agonists; Animals; Calcium; Calcium Radioisotopes; Clonidine; Egtazic Acid; In Vitr | 1989 |
Analysis of the presence of postjunctional alpha-2 adrenoceptors in the rat anococcygeus muscle.
Topics: Animals; Clonidine; Dioxanes; Electric Stimulation; Idazoxan; In Vitro Techniques; Male; Muscle Cont | 1989 |
Endothelium modulates the effects of alpha-adrenoceptor agonists in vascular smooth muscle.
Topics: Acetylcholine; Adrenergic alpha-Agonists; Animals; Aorta, Thoracic; Arteries; Clonidine; Endothelium | 1989 |
Effects of NG-monomethyl-L-arginine on field stimulation-induced decreases in cytosolic Ca2+ levels and relaxation in the rat anococcygeus muscle.
Topics: Animals; Arginine; Calcium; Clonidine; Cytosol; Electric Stimulation; In Vitro Techniques; Male; Mus | 1989 |
Contractant and relaxant properties of the female rabbit urethral submucosa.
Topics: Adrenergic alpha-Antagonists; Animals; Clonidine; Electric Stimulation; Female; In Vitro Techniques; | 1985 |
Physiological antagonism caused by adrenergic stimulation of canine tracheal muscle.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Animals; Clonidine; Dogs; Female; Male; M | 1986 |
Neither morphine nor clonidine influence the non-adrenergic, non-cholinergic inhibitory response in the rat gastric fundus.
Topics: Animals; Clonidine; Electric Stimulation; Female; Gastric Fundus; In Vitro Techniques; Morphine; Mus | 1986 |
[In vitro study of the non-adrenergic non-cholinergic innervation of the rat and cat stomach].
Topics: Animals; Cats; Clonidine; Electric Stimulation; Enkephalins; Female; Gastric Fundus; In Vitro Techni | 1986 |
Evidence that cGMP is the mediator of endothelium-dependent inhibition of contractile responses of rat arteries to alpha-adrenoceptor stimulation.
Topics: Acetylcholine; Adrenergic alpha-Agonists; Aminoquinolines; Animals; Aorta; Clonidine; Cyclic GMP; En | 1987 |
Responsiveness of isolated monkey coronary arteries contracted with alpha 1- and alpha 2-adrenoceptor agonists to diltiazem.
Topics: Adrenergic alpha-Agonists; Animals; Clonidine; Coronary Vessels; Diltiazem; Dinoprost; Female; In Vi | 1988 |
Myorelaxant effect after intrathecal injection of antispastic drugs in rats.
Topics: Animals; Baclofen; Clonidine; Dose-Response Relationship, Drug; Female; H-Reflex; Injections, Spinal | 1989 |
Comparison of the responses to drugs acting on adrenoreceptors and muscarinic receptors in human isolated corpus cavernosum and cavernous artery.
Topics: Acetylcholine; Aged; Carbachol; Clonidine; Electric Stimulation; Ethanolamines; Humans; In Vitro Tec | 1985 |
Effects of sophoramine, an alkaloid from Sophora alopecuroides on isolated dog blood vessels.
Topics: Adrenergic Fibers; Alkaloids; Animals; Cerebral Arteries; Clonidine; Coronary Vessels; Dinoprost; Do | 1988 |