clonidine has been researched along with Muscle Contraction in 459 studies
Clonidine: An imidazoline sympatholytic agent that stimulates ALPHA-2 ADRENERGIC RECEPTORS and central IMIDAZOLINE RECEPTORS. It is commonly used in the management of HYPERTENSION.
clonidine (amino form) : A clonidine that is 4,5-dihydro-1H-imidazol-2-amine in which one of the amino hydrogens is replaced by a 2,6-dichlorophenyl group.
Muscle Contraction: A process leading to shortening and/or development of tension in muscle tissue. Muscle contraction occurs by a sliding filament mechanism whereby actin filaments slide inward among the myosin filaments.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Seventy-eight patients with tension-type headache (TH) were treated with tizanidine hydrochloride (tizanidine)." | 9.07 | Treatment of tension-type headache with tizanidine hydrochloride: its efficacy and relationship to the plasma MHPG concentration. ( Awaki, E; Kowa, H; Shimomura, T; Takahashi, K, 1991) |
| "The aim of this study was to clarify the changes of inhibitory interneuronal activity in patients with chronic tension-type headache with disorder of pericranial muscle after treatment, and the pharmacological mechanisms of tizanidine--an alpha 2 adrenergic agonist." | 9.07 | Effects of tizanidine administration on exteroceptive suppression of the temporalis muscle in patients with chronic tension-type headache. ( Nakashima, K; Sakuma, K; Shimoda, M; Takahashi, K; Tumura, R; Wang, Y, 1994) |
| "The efficacy of tizanidine in chronic tension-type headache was compared with placebo in a randomized, double-blind and cross-over study in 37 women aged 20 to 59 years with a history of headache for 7 months to 30 years (median 5 years)." | 9.07 | Tizanidine in chronic tension-type headache: a placebo controlled double-blind cross-over study. ( Fogelholm, R; Murros, K, 1992) |
| " The aim of this study was to compare the effect of EM574 with that of cisapride on gastric motility and emptying in normal and gastroparesis dogs." | 7.70 | Effects of EM574 and cisapride on gastric contractile and emptying activity in normal and drug-induced gastroparesis in dogs. ( Itoh, Z; Mizumoto, A; Mochiki, E; Omura, S; Suzuki, H; Tanaka, T, 1998) |
| "This study examined the interaction of chloroethylclonidine with alpha-adrenoceptor agonists in canine endothelium-denuded dorsal pedal artery and saphenous vein before (non-paced) and at end-stage heart failure which was induced by rapid ventricular pacing (250 bpm for no more than four weeks)." | 7.69 | Chloroethylclonidine and alpha-adrenoceptor agonist interaction in blood vessels following heart failure. ( Forster, C; Le Tran, Y, 1997) |
| "A randomized, double-blind, placebo-controlled, dose-response study of tizanidine hydrochloride (8 or 16 mg)." | 6.68 | Relationship of the antispasticity effect of tizanidine to plasma concentration in patients with multiple sclerosis. ( Cohen, JA; Francis, GS; Hudson, S; Lindsey, JW; Lynch, SG; Mass, MK; Nance, PW; O'Connor, P; Schapiro, RT; Shellenberger, K; Sheremata, WA; Vollmer, T; Whitham, R, 1997) |
| "Seventy-eight patients with tension-type headache (TH) were treated with tizanidine hydrochloride (tizanidine)." | 5.07 | Treatment of tension-type headache with tizanidine hydrochloride: its efficacy and relationship to the plasma MHPG concentration. ( Awaki, E; Kowa, H; Shimomura, T; Takahashi, K, 1991) |
| "The aim of this study was to clarify the changes of inhibitory interneuronal activity in patients with chronic tension-type headache with disorder of pericranial muscle after treatment, and the pharmacological mechanisms of tizanidine--an alpha 2 adrenergic agonist." | 5.07 | Effects of tizanidine administration on exteroceptive suppression of the temporalis muscle in patients with chronic tension-type headache. ( Nakashima, K; Sakuma, K; Shimoda, M; Takahashi, K; Tumura, R; Wang, Y, 1994) |
| "The efficacy of tizanidine in chronic tension-type headache was compared with placebo in a randomized, double-blind and cross-over study in 37 women aged 20 to 59 years with a history of headache for 7 months to 30 years (median 5 years)." | 5.07 | Tizanidine in chronic tension-type headache: a placebo controlled double-blind cross-over study. ( Fogelholm, R; Murros, K, 1992) |
| " effect on clonidine and haloperidol induced catalepsy, milk-induced leucocytosis and eosinophilia, mast cell stabilizing activity in mice and studies on smooth muscle preparation of guinea pig ileum (in vitro)." | 3.78 | Antihistaminic and antiallergic actions of extracts of Solanum nigrum berries: possible role in the treatment of asthma. ( Bhawar, SB; Nirmal, SA; Patel, AP; Pattan, SR, 2012) |
| " Clonidine-induced central apneas were always associated with continuous tonic activation of the MPC." | 3.70 | Clonidine induces upper airway closure in awake goats. ( Bisgard, GE; Herman, JK; O'Halloran, KD, 2000) |
| " The aim of this study was to compare the effect of EM574 with that of cisapride on gastric motility and emptying in normal and gastroparesis dogs." | 3.70 | Effects of EM574 and cisapride on gastric contractile and emptying activity in normal and drug-induced gastroparesis in dogs. ( Itoh, Z; Mizumoto, A; Mochiki, E; Omura, S; Suzuki, H; Tanaka, T, 1998) |
| " All responses were tetrodotoxin-sensitive, the fast longitudinal muscle contraction and the intraluminal pressure response being caused by both pre- and postganglionic cholinergic nerves." | 3.69 | A simple method for measuring the effects of drugs on intestinal longitudinal and circular muscle. ( Coupar, IM; Liu, L, 1996) |
| " Mitragynine (3-10 microM) did not show any effect on the smooth muscle contraction induced by acetylcholine or histamine." | 3.69 | Inhibitory effect of mitragynine, an alkaloid with analgesic effect from Thai medicinal plant Mitragyna speciosa, on electrically stimulated contraction of isolated guinea-pig ileum through the opioid receptor. ( Horie, S; Watanabe, K; Yamamoto, LT; Yano, S, 1997) |
| "This study examined the interaction of chloroethylclonidine with alpha-adrenoceptor agonists in canine endothelium-denuded dorsal pedal artery and saphenous vein before (non-paced) and at end-stage heart failure which was induced by rapid ventricular pacing (250 bpm for no more than four weeks)." | 3.69 | Chloroethylclonidine and alpha-adrenoceptor agonist interaction in blood vessels following heart failure. ( Forster, C; Le Tran, Y, 1997) |
| " We demonstrated tracheal smooth muscle contraction by intra-arterial administration of acetylcholine, histamine, 5-hydroxy-tryptamine, phenylephrine, and clonidine using isometric technique in vivo." | 3.68 | [Measurement of isometric tracheal tension induced by injection into tracheal arterial circulation in vivo]. ( Kagaya, M; Miura, K; Miura, M; Miura, S; Onodera, A; Shioya, T; Yoshida, K, 1991) |
| " Phenylephrine (1 microM-1 mM) was less effective in causing muscle contraction and methoxamine produced no contraction." | 3.67 | Alpha 2-adrenoceptor-mediated contractile response to catecholamines in smooth muscle strips isolated from rainbow trout stomach (Salmo gairdneri). ( Kitazawa, T; Kondo, H; Temma, K, 1986) |
| " Four groups of rats: hypothyroid, hyperthyroid, thyroxine (0." | 3.67 | The effect of hyperthyroidism and hypothyroidism on alpha 1- and alpha 2-adrenergic responsiveness in rat aortic smooth muscle. ( Cheema, IR; Peoples, B; Rahmani, MA; Riley, SR; Sen, S, 1987) |
| " Clonidine (alpha 2 agonist) did not enhance ACh release or nerve-stimulated muscle contractions, while phenylephrine (alpha 1 agonist) and norepinephrine increased muscle contractions up to 19." | 3.66 | Noradrenergic-mediated potentiation of acetylcholine release from the phrenic nerve: evidence for presynaptic alpha 1-adrenoceptor involvement. ( Gerald, MC; Snider, RM, 1982) |
| "A randomized, double-blind, placebo-controlled, dose-response study of tizanidine hydrochloride (8 or 16 mg)." | 2.68 | Relationship of the antispasticity effect of tizanidine to plasma concentration in patients with multiple sclerosis. ( Cohen, JA; Francis, GS; Hudson, S; Lindsey, JW; Lynch, SG; Mass, MK; Nance, PW; O'Connor, P; Schapiro, RT; Shellenberger, K; Sheremata, WA; Vollmer, T; Whitham, R, 1997) |
| " The study consisted of 4 parts: I, double-blind cross-over trial at maximal dosage 10 mg/day in 13 patients; II, open trial at maximal dosage 32 mg/day in 10 patients; III, long-term medication at dosage 32 mg/day for 6-15 months in 4 patients; IV, single dose (12 mg) administration in 3 patients." | 2.65 | Antiparetic and antispastic effects induced by tizanidine in patients with spastic paresis. ( Gransberg, L; Knutsson, E; Mårtensson, A, 1982) |
| "In phenoxybenzamine-pretreated preparations, Sgd 101/75 (400 microM) did not antagonise NA (maximal effect and EC50 values not changed significantly), so it was concluded that Sgd 101/75 and NA interact with different alpha 1-adrenoceptor subtypes in this tissue." | 2.36 | Sgd 101/75: a sympathomimetic that can be used to identify a new subtype of alpha-adrenoceptor, the alpha 1s-adrenoceptor. ( Chadwick, MA; Coates, J; Ismail, S; Jahn, U; Lawson, K; Thiele, K; Turner, N; Weetman, DF, 1983) |
| "Clonidine was unable to alter the noradrenaline contractions if the in vitro pre-treatment was made in the presence of idazoxan (α2-adrenoceptor antagonist), whereas prazosin (α1-adrenoceptor antagonist) was ineffective." | 1.40 | Epididymal contraction and sperm parameters are affected by clonidine. ( Barnabe, VH; da Silva Júnior, ED; Dalmazzo, A; de Agostini Losano, JD; de Souza, BP; Jurkiewicz, A; Jurkiewicz, NH; Nichi, M; Rodrigues, JQ; Vilela, VV, 2014) |
| " Drugs functionally or structurally related to clonidine, such as oxymetazoline, alpha-methylnorepinephrine and moxonidine, did not have their dose-response curves altered." | 1.31 | Contractile responses of the rat vas deferens after epithelium removal. ( Garcez-do-Carmo, L; Jurkiewicz, A; Jurkiewicz, NH; Okpalaugo, EO, 2002) |
| " Administration of both non-selective and selective alpha-adrenoceptor agonists in doses of 1-40 microg noradrenaline kg(-1) body weight (BW), 1-100 microg clonidine kg(-1) BW, or 100-800 mg methoxamine kg(-1) BW enhanced contractions of the proximal cauda epididymidis in a dose-response manner." | 1.31 | Mediation of contraction in rat cauda epididymidis by alpha-adrenoceptors. ( Chaturapanich, G; Maythaarttaphong, S; Pholpramool, C; Verawatnapakul, V, 2002) |
| " These effects are probably mediated via central mechanisms, since there was an approximate 8 fold rightward shift of the dose-response curve in the pithed SHR (indicating a weakened cardiovascular effect)." | 1.31 | Agmatine, an endogenous ligand at imidazoline binding sites, does not antagonize the clonidine-mediated blood pressure reaction. ( Dominiak, P; Qadri, F; Raasch, W; Schäfer, U, 2002) |
| "Tizanidine (TZD) is an alpha-2-adrenergic drug with potential spinal analgesic action and could be a substitute or additive for intrathecal (i." | 1.30 | Distribution, tolerability and tissue compatibility of intrathecal tizanidine in the sheep. ( Loew, M; Ochs, G; Tonn, J; Toyka, K, 1998) |
| " Pretreatment with yohimbine shifted the dose-response curve for dopamine to the right in femoral veins, but not in arteries." | 1.30 | Dopamine releases endothelium-derived relaxing factor via alpha 2-adrenoceptors in canine vessels: comparisons between femoral arteries and veins. ( Fujiwara, H; Inoue, K; Ito, H; Minatoguchi, S; Segawa, T; Wada, H, 1998) |
| "Pretreatment with chlorethylclonidine (CEC) at concentrations ranging from 0." | 1.29 | Pharmacological evidence of distinct alpha 1-adrenoceptor subtypes mediating the contraction of human prostatic urethra and peripheral artery. ( Hatano, A; Koizumi, T; Komeyama, T; Takahashi, H; Takeda, M; Tamaki, M, 1994) |
| " The potentiating action of L-NNA on noradrenaline-induced contractions could also be observed in the presence of yohimbine or rauwolscine, although dose-response curves were shifted to the right." | 1.29 | Involvement of alpha-adrenoceptors in the endothelium-dependent depression of noradrenaline-induced contraction in rat aorta. ( Kaneko, K; Sunano, S, 1993) |
| "Pretreatment with chlorethylclonidine (10(-4) M for 30 min) did not alter the noradrenaline contractions in the vas deferens, but contractions to noradrenaline and phenylephrine in the spleen were shifted 30 and 300 fold to the right of the control curve, respectively." | 1.29 | Evidence for a functional alpha 1A- (alpha 1C-) adrenoceptor mediating contraction of the rat epididymal vas deferens and an alpha 1B-adrenoceptor mediating contraction of the rat spleen. ( Burt, RP; Chapple, CR; Marshall, I, 1995) |
| "Visceral pain is an important component of many clinical pain states." | 1.29 | Visceral antinociceptive effects of spinal clonidine combined with morphine, [D-Pen2, D-Pen5] enkephalin, or U50,488H. ( Collins, JG; Harada, Y; Kishikawa, K; Kitahata, LM; Nishioka, K, 1995) |
| "Morphine did not inhibit noncholinergic contractions." | 1.29 | Differential inhibition of cholinergic and noncholinergic neurogenic contractions by mu opioid and alpha-2 adrenergic agonists in guinea pig ileum. ( Galligan, JJ, 1993) |
| " Concentration- or dose-response curves for norepinephrine were obtained from aortic rings, superior mesenteric artery rings or the isolated perfused mesenteric vasculature from male Sprague-Dawley rats." | 1.29 | Functional distribution and role of alpha-1 adrenoceptor subtypes in the mesenteric vasculature of the rat. ( Fleming, WW; Kong, JQ; Taylor, DA, 1994) |
| " In particular, a 3-bromo-5-isoxazolecarbonyl derivative, selected for further in vivo investigation, was provided with as high antihypertensive action as prazosin in spontaneously hypertensive rats (SHR) coupled to a shallow dose-response curve by oral route." | 1.28 | New isoxazole derivatives provided with antihypertensive activity. ( Carenzi, A; Chiarino, D; Napoletano, M; Reggiani, A; Sala, A; Sala, R, 1989) |
| "05) without affecting exogenously applied acetylcholine dose-response curves." | 1.28 | Role of K+ channels in the modulation of cholinergic neural responses in guinea-pig and human airways. ( Barnes, PJ; Belvisi, MG; Miura, M; Stretton, CD; Yacoub, MH, 1992) |
| " The alpha 2-blocking agent yohimbine shifted the dose-response curve of the contractile response to the alpha 2-agonist, clonidine, in a dose-dependent manner, 10(-7) M causing a 10 fold shift." | 1.28 | The contribution of alpha-adrenoceptors to neurally-mediated contractions of the rabbit urethral smooth muscle. ( Brading, AF; Chen, HI, 1992) |
| "Tizanidine (TIZ) has long been known to be an alpha 2-adrenoceptor agonist and inhibitor of ASP and GLU release." | 1.28 | Effects of tizanidine on morphine physical dependence: attenuation and intensification. ( Ariciŏglu, F; Dizdar, Y; Esin, Y; Koyuncuŏglu, H; Uresin, Y, 1992) |
| "WB 4101 was found to be equally effective in antagonizing noradrenaline on all arteries." | 1.28 | Vascular alpha-adrenoceptor affinity variation is not due to varying populations of subtypes distinguished by WB 4101 and chlorethylclonidine. ( Bevan, JA; Bevan, RD; Oriowo, MA, 1992) |
| "tizanidine was antagonized by co-administration of prazosin but not by yohimbine." | 1.28 | Myorelaxant effect after intrathecal injection of antispastic drugs in rats. ( Klockgether, T; Schwarz, M; Sontag, KH; Turski, L; Wüllner, U, 1989) |
| " Dose-response curves for noradrenaline, phenylephrine and clonidine were determined isometrically on the mouse vas deferens at 26 degrees C, 15 degrees C and compared to the one obtained at 37 degrees C." | 1.28 | Effect of temperature reduction on the reactivity of the mouse vas deferens to adrenergic drugs. ( Bidon, JC; Blin, M; Gogny, M; Jondet, A; Souilem, O, 1992) |
| "Pretreatment with chlorethylclonidine (CEC) slightly attenuated only the contractions induced by low concentrations of noradrenaline." | 1.28 | Relation between adrenergic neurogenic contraction and alpha 1-adrenoceptor subtypes in dog mesenteric and carotid arteries and rabbit carotid arteries. ( Muramatsu, I, 1991) |
| "Bethanechol was shown to induce contraction in mouse spleen." | 1.28 | Bethanechol induced contraction in mouse spleen. ( Wong, KK, 1990) |
| "In reserpine pretreated animals amphetamine 5." | 1.28 | Amphetamine antagonizes the presynaptic inhibitory effect of clonidine through an interaction at the level of the alpha 2-adrenoceptors. ( Fiszman, ML; Luchelli-Fortis, MA; Stefano, FJ, 1989) |
| " The drugs induced dose-dependent contractions in all subjects, and dose-response curves were constructed." | 1.28 | Comparative effects of the alpha-adrenoceptor agonists noradrenaline, phenylephrine and clonidine in the human saphenous vein in vivo and in vitro. ( Andersson, KE; Norgren, L; Sjöberg, T; Steen, S, 1989) |
| " The presynaptic alpha-adrenoceptor antagonist activity of the drugs was quantitatively determined by studying the effect of increasing concentrations on the clonidine dose-response curve in the electrically stimulated vas deferens." | 1.27 | Effects of raubasine stereoisomers on pre- and postsynaptic alpha-adrenoceptors in the rat vas deferens. ( Demichel, P; Roquebert, J, 1984) |
| "Nifedipine was equally potent at inhibiting the slow component of both alpha-1 and alpha-2 adrenoceptor-stimulated contractions and contractions due to KCl depolarization." | 1.27 | Nifedipine and alpha adrenoceptors in rat aorta. I. Role of extracellular calcium in alpha-1 and alpha-2 adrenoceptor-mediated contraction. ( Carrier, GO; Scarborough, NL, 1984) |
| "Benextramine was equipotent against the imidazoline, clonidine and the thiazoloazepine B-HT920, however, higher concentrations of benextramine were required for an equivalent non-competitive antagonism of the beta-phenethylamine, alpha-methylnoradrenaline." | 1.27 | The action and interaction of beta-phenethylamines and imidazolines on prejunctional alpha 2-adrenoceptors of guinea-pig ileum in the presence of the non-competitive antagonist benextramine. ( Mottram, DR; Thakar, Y, 1984) |
| " Clonidine also decreased the slope of the ACh dose-response curve and maximal response in denervated mouse diaphragms as well as the carbachol response in the chinck muscle." | 1.27 | Effect of clonidine on neuromuscular transmission and the nicotinic acetylcholine receptor. ( Chang, CC; Chiou, LC, 1984) |
| "Prazosin (10(-7) M) was effective in causing inhibition of cellular Ca++ influx initiated by agonists whereas yohimbine (10(-6) M) had no effect." | 1.27 | Alpha adrenergic receptor subtype associated with receptor binding, Ca++ influx, Ca++ release and contractile events in the rabbit aorta. ( Awad, R; Deth, RC; Payne, R, 1983) |
| " Prazosin caused a parallel shift to the right of the dose-response curve to phenylephrine, and not to clonidine in the vessels." | 1.27 | [Characteristics of alpha adrenoceptors of lymphatics and their physiological significance]. ( Azuma, T; Ohhashi, T, 1983) |
| "Lisuride was alpha 2-selective, having a pA2 value of 9." | 1.27 | In vitro selectivity of lisuride and other ergot derivatives for alpha 1- and alpha 2-adrenoceptors. ( McPherson, GA, 1984) |
| "Clonidine was the most potent agonist against peristaltic reflex and the weakest agonist in relaxing circular muscle." | 1.27 | Changes in sensitivity to the inhibitory effects of adrenergic agonists on intestinal motor activity after chronic sympathetic denervation. ( Crema, A; D'Angelo, L; Frigo, GM; Lecchini, S; Marcoli, M; Tonini, M, 1984) |
| "Methoxamine was a partial agonist relative to norepinephrine whereas clonidine, xylazine, B-HT 920 and B-HT 933 produced minimal contractions." | 1.27 | Alpha-1 adrenoceptors and calcium in isolated canine coronary arteries. ( Aarhus, LL; Rimele, TJ; Rooke, TW; Vanhoutte, PM, 1983) |
| "(-) Idazoxan was selective for postsynaptic alpha 2-adrenoceptors and antagonized presynaptic alpha 2-adrenoceptors of the rat." | 1.27 | (Imidazolinyl-2)-2-benzodioxane 1-4 (idazoxan) and its stereoisomers, new alpha 2-antagonists. ( Dabiré, H; Mouille, P; Schmitt, H, 1985) |
| "Yohimbine was also more potent than the synthetic antagonists in blocking the B-HT 933-induced contractile responses of the dog saphenous vein and preventing adrenaline-induced aggregation of human platelets." | 1.27 | Studies of alpha 2-adrenoceptor antagonist potency in vitro: comparisons in tissues from rats, rabbits, dogs and humans. ( Lattimer, N; Rhodes, KF; Waterfall, JF, 1985) |
| "Clonidine was significantly more potent than 6-FNA as an inhibitory agonist, and the potency of clonidine was not modified after cocaine, pargyline or reserpine." | 1.27 | Differential blocking actions of idazoxan against the inhibitory effects of 6-fluoronoradrenaline and clonidine in the rat vas deferens. ( Hicks, PE; Langer, SZ; Macrae, AD, 1985) |
| "(+)-Amosulalol and YM-11133 were 14 and 9." | 1.27 | Adrenoceptor blocking properties of the stereoisomers of amosulalol (YM-09538) and the corresponding desoxy derivative (YM-11133). ( Honda, K; Miyata-Osawa, A; Takenaka, T; Terai, M, 1986) |
| "Clonidine did not increase cGMP levels in vascular preparations with intact endothelia, in the presence or absence of LY83583." | 1.27 | Evidence that cGMP is the mediator of endothelium-dependent inhibition of contractile responses of rat arteries to alpha-adrenoceptor stimulation. ( Diamond, J; Harris, KH; MacLeod, KM; Ng, DD, 1987) |
| " The antagonism of both receptor types was reversible since washing of the tissues after incubation with DMPEA brought the agonist dose-response curve back to the control value." | 1.27 | Alpha-adrenoceptor occupancy by N,N-dimethyl-2-bromo-2-phenethylamine hydrobromide (DMPEA) in rat vas deferens. ( Brasili, L; Cassinelli, A; Giardinà, D; Gulini, U; Melchiorre, C; Quaglia, W, 1988) |
| " Prazosin (10(-8) M-10(-6) M, alpha 1-adrenoceptor antagonist) produced a rightward shift of the phenylephrine and clonidine dose-response curve in both the trigone and urethra." | 1.27 | Alpha 1- and alpha 2-adrenoceptors in the smooth muscle of isolated rabbit urinary bladder and urethra. ( Satake, N; Shibata, S; Ueda, S, 1984) |
| "Clonidine was the most potent inhibitor of the contractions, followed closely by B-HT 920." | 1.27 | Prejunctional alpha 2-adrenoceptor mediated inhibitory action of clonidine and B-HT 920, but not urapidil in guinea pig ileum. ( Shebuski, RJ; Zimmerman, BG, 1985) |
| "Theophylline is a competing antagonist of adenosine and a noncompeting antagonist of baclofen, clofelin and morphine." | 1.27 | [Theophylline-induced changes in the presynaptic effects of adenosine, baclofen, clofelin and morphine in the myenteric plexus of the guinea pig]. ( Kharin, NA; Komissarov, IV; Serdiuk, SE, 1987) |
| "Prazosin was 300 times more active than rauwolscine in inhibiting NA-induced contractions." | 1.27 | Comparison of the responses to drugs acting on adrenoreceptors and muscarinic receptors in human isolated corpus cavernosum and cavernous artery. ( Andersson, KE; Hedlund, H, 1985) |
| "Urapidil is a novel antihypertensive agent, chemically related to uracil." | 1.27 | Cardiovascular effects and interaction with adrenoceptors of urapidil. ( Beckeringh, JJ; de Jonge, A; Thoolen, MJ; Timmermans, PB; van Zwieten, PA; Wilffert, B, 1985) |
| "Naloxone treatment of mice did not affect the sensitivity of the isolated vas deferens to noradrenaline, carbachol or potassium chloride." | 1.27 | Effects of chronic drug treatment on the sensitivity of mouse vas deferens to drugs. ( McCulloch, CR; Pollock, D, 1985) |
| "Clonidine was inactive as an antinicotinic agent and there was no correlation between a compound's ability to inhibit contractions induced by field stimulation and its antinicotinic activity." | 1.26 | Pharmacological effects of 2-aminotetralins, octahydrobenzo[f]quinolines and clonidine on the isolated guinea pig ileum. ( Abou Zeit-Har, MS; Arnerić, SP; Cannon, JG; Lecompte, J; Lee, T; Long, JP; Maixner, W; Verimer, T, 1981) |
| " The order of affinity (pA2) for presynaptic alpha-receptors, as assessed from parallel shift of the dose-response curve to clonidine, was: phentolamine greater than yohimbine greater than tolazoline greater than E-643 greater than or equal to prazosin." | 1.26 | Comparison of pre- and postsynaptic alpha-adrenoceptor blocking effects of E-643 in the isolated vas deferens of the rat. ( Shoji, T, 1981) |
| " Presynaptic alpha-adrenoceptor antagonist activity was assessed by studying the effects of increasing concentrations of the antagonists on cumulative clonidine dose-response curves on the stimulated vas deferens." | 1.26 | Selectivity of blocking agents for pre-and postsynaptic alpha-adrenoceptors. ( Doxey, JC; Smith, CF; Walker, JM, 1977) |
| " The increase was blocked by phenoxybenzamine at a dosage level of 20 mg/kg which did not, of itself, reduce flexor reflex amplitude." | 1.26 | A system for measuring the noradrenaline receptor contribution to the flexor reflex. ( Austin, JH; Fuxe, K; Nygren, LG, 1976) |
| " 2 In the absence of morphine the inhibitory effects of the presynaptic alpha-adrenoceptor agonists, clonidine and oxymetazoline were much reduced and the dose-response curve was flat." | 1.26 | The inhibitory effects of presynaptic alpha-adrenoceptor agonists on contractions of guinea-pig ileum and mouse vas deferens in the morphine-dependent and withdrawn states produced in vitro. ( Gillan, MG; Kosterlitz, HW; Robson, LE; Waterfield, AA, 1979) |
| "Pimozide has no such effect." | 1.26 | The effect of haloperidol, spiperone and pimozide on the flexor reflex of the hind limb of the spinal rat. ( Maj, J; Palider, W; Rawłów, A, 1978) |
| "Clonidine has a contractile effect in the isolated rabbit aorta which can be blocked by alpha-adrenergic antagonist, phentolamine." | 1.26 | Possible involvement of endogenous histamine in the myotropic effect of clonidine on the isolated rabbit aorta. ( Bökesoy, TA; Ercan, ZS; Ersoy, F; Türker, RK; Zengil, H, 1978) |
| "Both tolazoline and clonidine produce agonist effects sensitive to histamine H2-receptor antagonism in whole animals and a variety of isolated tissues." | 1.26 | The histamine-like effects of tolazoline and clonidine:: evidence against direct activity at histamine receptors. ( Angus, JA; Kenakin, TP, 1981) |
| " Dose-response curves for the pre- and postsynaptic effects of eight alpha-receptor agonists were determined on superfused strips of the artery in the presence of cocaine, corticosterone and propranolo." | 1.25 | Relative pre- and postsynaptic potencies of alpha-adrenoceptor agonists in the rabbit pulmonary artery. ( Endo, T; Starke, K; Taube, HD, 1975) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 231 (50.33) | 18.7374 |
| 1990's | 173 (37.69) | 18.2507 |
| 2000's | 39 (8.50) | 29.6817 |
| 2010's | 16 (3.49) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Stillings, MR | 1 |
| England, CD | 1 |
| Welbourn, AP | 1 |
| Smith, CF | 4 |
| Obara, K | 1 |
| Michino, M | 1 |
| Ito, M | 2 |
| Ao, L | 1 |
| Sawada, A | 1 |
| Yamaki, F | 1 |
| Matsuo, K | 2 |
| Yoshio, T | 1 |
| Tanaka, Y | 1 |
| Dantas da Silva Júnior, E | 1 |
| Palmieri de Souza, B | 1 |
| Rodrigues, JQ | 2 |
| Caricati-Neto, A | 3 |
| Jurkiewicz, A | 9 |
| Jurkiewicz, NH | 8 |
| Rayment, SJ | 1 |
| Simpson, JA | 1 |
| Eames, T | 1 |
| Acheson, AG | 1 |
| Dashwood, MR | 1 |
| Henry, Y | 1 |
| Gruss, H | 1 |
| Scholefield, JH | 1 |
| Wilson, VG | 4 |
| da Silva Júnior, ED | 1 |
| de Souza, BP | 1 |
| Vilela, VV | 1 |
| Nichi, M | 1 |
| de Agostini Losano, JD | 1 |
| Dalmazzo, A | 1 |
| Barnabe, VH | 1 |
| de Souza Rossignoli, P | 1 |
| Yamamoto, FZ | 1 |
| Pereira, OC | 1 |
| Chies, AB | 1 |
| Apostolova, E | 1 |
| Zagorchev, P | 1 |
| Kokova, V | 1 |
| Peychev, L | 1 |
| Heydari, F | 1 |
| Mehr, SE | 1 |
| Samini, M | 1 |
| Gourdin, MJ | 1 |
| Ponchau, O | 1 |
| Jamart, J | 1 |
| De Kock, M | 1 |
| Rummery, NM | 1 |
| Tripovic, D | 1 |
| McLachlan, EM | 1 |
| Brock, JA | 1 |
| Wong, ES | 1 |
| Man, RY | 1 |
| Vanhoutte, PM | 3 |
| Ng, KF | 1 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Effects of Nebivolol Versus Metoprolol on Blood Flow Responses to Exercise and Angiotensin II in Hypertensive Patients[NCT01502787] | Phase 4 | 46 participants (Actual) | Interventional | 2009-04-30 | Completed | ||
| The Effects of Systemic Alfuzosin and Tamsulosin Hydrochloride on Choroidal Thickness and Pupil Diameter Sizes in Cases With Benign Prostatic Hyperplasia[NCT03144596] | Phase 4 | 63 participants (Actual) | Interventional | 2015-10-29 | Completed | ||
| Guanfacine for PONV and Pain After Sinus Surgery[NCT02882854] | 84 participants (Actual) | Interventional | 2016-11-30 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
(NCT01502787)
Timeframe: 12 weeks after initiation of metoprolol
| Intervention | mmHg (Mean) |
|---|---|
| Metoprolol | 114 |
| Nebivolol | 113 |
(NCT01502787)
Timeframe: 12 weeks
| Intervention | mmHg (Mean) |
|---|---|
| Initial Treatment With Metoprolol | 101 |
| Initial Treatment With Nebivolol | 103 |
(NCT01502787)
Timeframe: 12 weeks after each specified medication
| Intervention | ml/min (Mean) |
|---|---|
| First Intervention Metoprolol: 12 Weeks | 96 |
| Second Intervention Nebivolol: 24 Weeks | 105 |
(NCT02882854)
Timeframe: Time frame between arrival and discharge in PACU, approximately 90 minutes
| Intervention | minutes (Median) |
|---|---|
| Guanfacine | 128 |
| Placebo | 110 |
PONV assessed using nVRS at 24 hours postop when 0 is no nausea and 10 is worst nausea. (NCT02882854)
Timeframe: 24 hours post op
| Intervention | score on a scale (Median) |
|---|---|
| Guanfacine | 0.00 |
| Placebo | 0.00 |
Postoperative pain assessment using VAS at 24 hours postop when 0 is no pain and 10 is worst pain (NCT02882854)
Timeframe: 24 hours postop
| Intervention | score on a scale (Median) |
|---|---|
| Guanfacine | 3 |
| Placebo | 2 |
Total narcotic requirement in PACU tallied in morphine equivalents during PACU stay (NCT02882854)
Timeframe: Time frame between arrival and discharge in PACU, approximately 90 minutes
| Intervention | morphine equivalents (Median) |
|---|---|
| Guanfacine | 8.75 |
| Placebo | 7.50 |
Maximum postoperative pain assessment assessed in PACU at 15, 30 and 60 minutes after PACU arrival using VAS when 0 is no pain and 10 is worst pain (NCT02882854)
Timeframe: 15, 30, 60 minutes after arriving in PACU
| Intervention | Participants (Count of Participants) | |||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 15 minutes after PACU admission72482977 | 15 minutes after PACU admission72482978 | 30 minutes after PACU admission72482977 | 30 minutes after PACU admission72482978 | 60 minutes after PACU admission72482977 | 60 minutes after PACU admission72482978 | |||||||||||||
| Mild (Pain nVRS 1-5) | Moderate/Severe (Pain nVRS 6-10) | None (Pain nVRS 0) | ||||||||||||||||
| Guanfacine | 31 | |||||||||||||||||
| Placebo | 24 | |||||||||||||||||
| Guanfacine | 0 | |||||||||||||||||
| Placebo | 5 | |||||||||||||||||
| Guanfacine | 8 | |||||||||||||||||
| Placebo | 10 | |||||||||||||||||
| Guanfacine | 18 | |||||||||||||||||
| Placebo | 20 | |||||||||||||||||
| Guanfacine | 7 | |||||||||||||||||
| Placebo | 6 | |||||||||||||||||
| Guanfacine | 14 | |||||||||||||||||
| Placebo | 14 | |||||||||||||||||
| Guanfacine | 12 | |||||||||||||||||
| Placebo | 16 | |||||||||||||||||
| Guanfacine | 6 | |||||||||||||||||
| Placebo | 13 | |||||||||||||||||
| Guanfacine | 21 | |||||||||||||||||
| Placebo | 12 | |||||||||||||||||
4 reviews available for clonidine and Muscle Contraction
| Article | Year |
|---|---|
Sites and mechanisms of dependence in the myenteric plexus of guinea pig ileum.
Topics: Acetylcholine; Adenosine; Animals; Clonidine; Cyclic AMP; Guinea Pigs; Humans; Ileum; In Vitro Techn | 1984 |
Sgd 101/75: a sympathomimetic that can be used to identify a new subtype of alpha-adrenoceptor, the alpha 1s-adrenoceptor.
Topics: Adrenergic alpha-Agonists; Animals; Clonidine; Electric Stimulation; Hemodynamics; Humans; Muscle Co | 1983 |
The alpha-adrenoceptor-mediated actions of chloroethylclonidine.
Topics: Adrenergic alpha-Antagonists; Animals; Aorta; Clonidine; Muscle Contraction; Muscle, Smooth, Vascula | 1997 |
Drug receptor mechanisms in smooth muscle: beta-chloroethylamine-sensitive and -resistant receptor mechanisms.
Topics: Adrenergic Agonists; Adrenergic alpha-Antagonists; Animals; Calcium; Clonidine; Guanosine Triphospha | 1997 |
12 trials available for clonidine and Muscle Contraction
| Article | Year |
|---|---|
Clonidine has a paradoxical effect on cyclic arousal and sleep bruxism during NREM sleep.
Topics: Adrenergic alpha-2 Receptor Agonists; Adult; Arousal; Clonidine; Cross-Over Studies; Double-Blind Me | 2010 |
Eperisone versus tizanidine for treatment of chronic low back pain.
Topics: Analysis of Variance; Chronic Pain; Clonidine; Drug Therapy, Combination; Female; Humans; Italy; Low | 2012 |
alpha1- and alpha2-adrenergic vasoconstriction is blunted in contracting human muscle.
Topics: Adrenergic alpha-Agonists; Adrenergic Uptake Inhibitors; Adult; Clonidine; Forearm; Humans; Male; Mu | 2003 |
Combined NO and PG inhibition augments alpha-adrenergic vasoconstriction in contracting human skeletal muscle.
Topics: Adenosine; Adrenergic alpha-Agonists; Adult; Blood Pressure; Clonidine; Humans; Male; Muscle Contrac | 2004 |
Impaired modulation of sympathetic alpha-adrenergic vasoconstriction in contracting forearm muscle of ageing men.
Topics: Adenosine; Adrenergic alpha-Agonists; Adult; Aged; Aging; Clonidine; Forearm; Hand Strength; Humans; | 2005 |
Antiparetic and antispastic effects induced by tizanidine in patients with spastic paresis.
Topics: Adult; Aged; Clinical Trials as Topic; Clonidine; Dose-Response Relationship, Drug; Double-Blind Met | 1982 |
Effects of tizanidine administration on exteroceptive suppression of the temporalis muscle in patients with chronic tension-type headache.
Topics: Clonidine; Electric Stimulation; Humans; Muscle Contraction; Muscle Relaxants, Central; Temporal Mus | 1994 |
Relationship of the antispasticity effect of tizanidine to plasma concentration in patients with multiple sclerosis.
Topics: Adrenergic alpha-Agonists; Canada; Cardiovascular System; Clonidine; Dose-Response Relationship, Dru | 1997 |
Adrenergic modulation of human colonic motor and sensory function.
Topics: Adrenergic Agents; Adult; Anxiety; Blood Pressure; Clonidine; Colon; Depression; Female; Gastrointes | 1997 |
[The effect of DS 103--282, a new type of myotonolyticum, on the contractile mechanism in human skeletal muscle (author's transl)].
Topics: Benzodiazepinones; Clinical Trials as Topic; Clonidine; Diazepam; Double-Blind Method; Humans; Muscl | 1977 |
Tizanidine in chronic tension-type headache: a placebo controlled double-blind cross-over study.
Topics: Adult; Analgesics; Chronic Disease; Clonidine; Depression; Dose-Response Relationship, Drug; Double- | 1992 |
Treatment of tension-type headache with tizanidine hydrochloride: its efficacy and relationship to the plasma MHPG concentration.
Topics: Clonidine; Fatty Acids, Nonesterified; Female; Headache; Humans; Male; Methoxyhydroxyphenylglycol; M | 1991 |
443 other studies available for clonidine and Muscle Contraction
| Article | Year |
|---|---|
Effect of methoxy substitution on the adrenergic activity of three structurally related alpha 2-adrenoreceptor antagonists.
Topics: Adrenergic alpha-Antagonists; Animals; Chemical Phenomena; Chemistry; Clonidine; Dioxanes; Dioxins; | 1986 |
Evaluation of Antidepressant Effects on Recovery of Electrical Field Stimulation-Induced Contractions that have been Suppressed by Clonidine in Isolated Rat Vas Deferens.
Topics: Adrenergic alpha-2 Receptor Agonists; Animals; Antidepressive Agents; Clonidine; Dose-Response Relat | 2019 |
Effects of clonidine in the isolated rat testicular capsule.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic Antagonists; Animals; Clonidine; Dose-Response Rela | 2014 |
Dual effects of α2 -adrenoceptors in modulating myogenic tone in sheep isolated internal anal sphincter.
Topics: Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-2 Receptor Agonists; Anal Canal; Animals; | 2014 |
Epididymal contraction and sperm parameters are affected by clonidine.
Topics: Adrenergic alpha-2 Receptor Agonists; Animals; Clonidine; Epididymis; Male; Muscle Contraction; Rats | 2014 |
Norepinephrine responses in rat renal and femoral veins are reinforced by vasoconstrictor prostanoids.
Topics: Animals; Clonidine; Endothelium, Vascular; Femoral Vein; Kidney; Male; Muscle Contraction; Muscle, S | 2015 |
Retigabine diminishes the effects of acetylcholine, adrenaline and adrenergic agonists on the spontaneous activity of guinea pig smooth muscle strips in vitro.
Topics: Acetylcholine; Adrenergic Agonists; Animals; Anthracenes; Carbamates; Cholinergic Agonists; Clonidin | 2017 |
alpha(1)- and alpha(2)-Adrenoceptor hyporesponsiveness in isolated bisected vas deferens of bile duct-ligated rats.
Topics: Adrenergic alpha-1 Receptor Agonists; Adrenergic alpha-2 Receptor Agonists; Animals; Bile Ducts, Ext | 2010 |
Prehypoxic clonidine administration improves vasomotricity of isolated rat aorta during reoxygenation.
Topics: Adrenergic alpha-2 Receptor Agonists; Animals; Aorta; Cell Hypoxia; Clonidine; Endothelium, Vascular | 2010 |
Sympathetic vasoconstriction is potentiated in arteries caudal but not rostral to a spinal cord transection in rats.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Arteries; Clonidine; Data Interpre | 2010 |
Dexmedetomidine induces both relaxations and contractions, via different {alpha}2-adrenoceptor subtypes, in the isolated mesenteric artery and aorta of the rat.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adrenergic alpha-1 Receptor Anta | 2010 |
Acotiamide hydrochloride (Z-338) enhances gastric motility and emptying by inhibiting acetylcholinesterase activity in rats.
Topics: Acetylcholinesterase; Animals; Benzamides; Cholinesterase Inhibitors; Clonidine; Electric Stimulatio | 2011 |
Medium-latency reflex response elicited from the flexor carpi radialis by radial nerve stimulation.
Topics: Adult; Clonidine; Electric Stimulation; Female; H-Reflex; Humans; Male; Middle Aged; Muscle Contract | 2012 |
Effects of imidazolines on neurogenic contraction in isolated urinary bladder detrusor strips from rabbit.
Topics: Adenosine Triphosphate; Agmatine; Animals; Carbachol; Clonidine; Dose-Response Relationship, Drug; E | 2012 |
Antihistaminic and antiallergic actions of extracts of Solanum nigrum berries: possible role in the treatment of asthma.
Topics: Animals; Anti-Allergic Agents; Asthma; Catalepsy; Clonidine; Eosinophilia; Fruit; Guinea Pigs; Halop | 2012 |
Acute effects of aflatoxins on guinea pig isolated ileum.
Topics: Aflatoxins; Animals; Apamin; Atropine; Clonidine; Dose-Response Relationship, Drug; Drug Interaction | 2002 |
Contractile responses of the rat vas deferens after epithelium removal.
Topics: Acetylcholine; Adrenergic alpha-Agonists; Adrenergic beta-Agonists; Animals; Clonidine; Electric Sti | 2002 |
Method for simultaneous recording of the prostatic contractile and urethral pressure responses in anesthetized rats and the effects of tamsulosin.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Clonidine; Electric Stimulation; M | 2002 |
Characterisation of bradykinin B1 and B2 receptors using rat isolated vas deferens.
Topics: Animals; Bradykinin; Bradykinin Receptor Antagonists; Clonidine; Dose-Response Relationship, Drug; E | 2003 |
Mediation of contraction in rat cauda epididymidis by alpha-adrenoceptors.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Clonidine; Dose-Response Relations | 2002 |
Alpha2-adrenoceptor ligands inhibit alpha1-adrenoceptor-mediated contraction of isolated rat arteries.
Topics: Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Re | 2002 |
Evidence for the role of alpha1D- and alpha1A-adrenoceptors in contraction of the rat mesenteric artery.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Clonidine; In Vitro Techniques; Ma | 2003 |
Dual effect of agmatine in the bisected rat vas deferens.
Topics: Adenosine Triphosphate; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Agmatine; Animals; | 2003 |
Effects of castration and of testosterone replacement on alpha(1)-adrenoceptor subtypes in the rat vas deferens.
Topics: Animals; Castration; Clonidine; Dioxanes; Dose-Response Relationship, Drug; Male; Muscle Contraction | 2003 |
Evidence that alpha(1B)-adrenoceptors are involved in noradrenaline-induced contractions of rat tail artery.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Algorithms; Animals; Arteries; Clonidine; D | 2004 |
Effects of clonidine and tricyclic antidepressants on gastric smooth muscle contractility.
Topics: Acetylcholine; Adrenergic alpha-Agonists; Animals; Antidepressive Agents, Tricyclic; Clonidine; Elec | 2004 |
Inhibitory effect of clonidine on cholinergic transmission.
Topics: Adrenergic alpha-Agonists; Analgesics; Anesthetics, Local; Animals; Clonidine; Molecular Structure; | 2005 |
Evidence that the plant cannabinoid Delta9-tetrahydrocannabivarin is a cannabinoid CB1 and CB2 receptor antagonist.
Topics: Animals; Arachidonic Acids; Benzoxazines; Cannabinoids; Cannabis; CHO Cells; Clonidine; Cricetinae; | 2005 |
(+)-Cyclazosin, a selective alpha1B-adrenoceptor antagonist: functional evaluation in rat and rabbit tissues.
Topics: Adrenergic alpha-1 Receptor Agonists; Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-Agon | 2005 |
Characterisation of alpha2-adrenoceptor subtypes involved in gastric emptying, gastric motility and gastric mucosal defence.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Clonidine; Disease Models, Animal; | 2005 |
Mediation of late excitation from human hand muscles via parallel group II spinal and group I transcortical pathways.
Topics: Adult; Aged; Arm; Cerebral Cortex; Clonidine; Cold Temperature; Electric Stimulation; Electromyograp | 2006 |
L-NAME pre-treatment partially inhibits the agmatine-evoked depression of the electrically induced twitch contraction of isolated rat vas deferens.
Topics: Adenosine Triphosphate; Adrenergic alpha-Agonists; Agmatine; Animals; Blood Pressure; Clonidine; Dos | 2006 |
Alpha1L-adrenoceptors mediate contractions of the isolated mouse prostate.
Topics: Adrenergic alpha-1 Receptor Agonists; Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-Agon | 2006 |
Sympathetic neurotransmission in the rat testicular capsule: functional characterization and identification of mRNA encoding alpha1-adrenoceptor subtypes.
Topics: Acetyl-CoA C-Acyltransferase; Adenosine Triphosphate; Adrenergic alpha-Antagonists; Adrenergic Uptak | 2006 |
Clonidine induced endothelium-dependent tonic contraction in circular muscle of the rat hepatic portal vein.
Topics: Adrenergic alpha-Agonists; Animals; Clonidine; Diclofenac; Endothelium, Vascular; Humans; Hypertensi | 2006 |
Expressions and mechanical functions of alpha1-adrenoceptor subtypes in hamster ureter.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Clonidine; Cricetinae; Dose-Respon | 2007 |
Pre- and postsynaptic mechanisms in the clonidine- and oxymetazoline-induced inhibition of gastric motility in the rat.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Carbachol; Clonidine; Gastrointest | 2007 |
Role of selective alpha and beta adrenergic receptor mechanisms in rat jejunal longitudinal muscle contractility.
Topics: Adrenergic alpha-Agonists; Adrenergic beta-Agonists; Animals; Clonidine; Disease Models, Animal; Dos | 2008 |
Upper airway pressure-flow relationships and pharyngeal constrictor EMG activity during prolonged expiration in awake goats.
Topics: Adrenergic alpha-Agonists; Air Pressure; Animals; Blood Gas Analysis; Clonidine; Dopamine; Electrode | 2008 |
Effects of raubasine stereoisomers on pre- and postsynaptic alpha-adrenoceptors in the rat vas deferens.
Topics: Animals; Clonidine; Electric Stimulation; In Vitro Techniques; Kinetics; Male; Muscle Contraction; M | 1984 |
Nifedipine and alpha adrenoceptors in rat aorta. I. Role of extracellular calcium in alpha-1 and alpha-2 adrenoceptor-mediated contraction.
Topics: Animals; Aorta; Calcium; Clonidine; Dose-Response Relationship, Drug; In Vitro Techniques; Male; Mus | 1984 |
Nifedipine and alpha adrenoceptors in rat aorta. II. Role of extracellular calcium in enhanced alpha-2 adrenoceptor-mediated contraction in diabetes.
Topics: Animals; Aorta; Calcium; Clonidine; Diabetes Mellitus, Experimental; Dose-Response Relationship, Dru | 1984 |
Comparison of alpha 2 adrenoreceptors on arterial smooth muscle and brain homogenates from spontaneously hypertensive and Wistar-Kyoto normotensive rats.
Topics: Animals; Arteries; Brain; Clonidine; Epinephrine; Guanabenz; In Vitro Techniques; Male; Membranes; M | 1984 |
Receptor interactions of imidazolines. IV. Structural requirements for alpha adrenergic receptor occupation and receptor activation by clonidine and a series of structural analogs in rat aorta.
Topics: Adrenergic alpha-Agonists; Animals; Aorta, Thoracic; Chemical Phenomena; Chemistry; Clonidine; Imida | 1980 |
Effects of some alpha-adrenoceptor agonists and antagonists on the guinea-pig ileum.
Topics: Acetylcholine; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Clonidine; Drug Int | 1980 |
Pharmacological effects of 2-aminotetralins, octahydrobenzo[f]quinolines and clonidine on the isolated guinea pig ileum.
Topics: 2-Naphthylamine; Acetylcholine; Animals; Clonidine; Electric Stimulation; Guinea Pigs; Histamine H1 | 1981 |
Alterations in prejunctional adrenoceptor function in guinea pig and rat vas deferens after chronic ganglionic blockade.
Topics: Animals; Chlorisondamine; Clonidine; Electric Stimulation; Ganglionic Blockers; Guinea Pigs; In Vitr | 1981 |
Comparison of pre- and postsynaptic alpha-adrenoceptor blocking effects of E-643 in the isolated vas deferens of the rat.
Topics: Adrenergic alpha-Antagonists; Animals; Clonidine; Dose-Response Relationship, Drug; In Vitro Techniq | 1981 |
Agonistic actions of DPI (2-(3,4-dihydroxyphenylimino)-imidazolidine) on alpha-adrenoceptors and dopamine receptors.
Topics: Adrenergic alpha-Agonists; Animals; Catecholamines; Clonidine; Dogs; Female; Guinea Pigs; Heart; Imi | 1981 |
The existence of a new subtype of alpha-adrenoceptor on the rat anococcygeus is revealed by SGD 101/75 and phenoxybenzamine.
Topics: Adrenergic alpha-Agonists; Animals; Clonidine; In Vitro Techniques; Muscle Contraction; Muscle, Smoo | 1982 |
Catecholamines act as alpha 2-adrenoceptors to cause contraction of circular smooth muscle of guinea-pig stomach.
Topics: Animals; Catecholamines; Clonidine; Dopamine; Guinea Pigs; In Vitro Techniques; Isoproterenol; Male; | 1982 |
Noradrenergic-mediated potentiation of acetylcholine release from the phrenic nerve: evidence for presynaptic alpha 1-adrenoceptor involvement.
Topics: Acetylcholine; Adrenergic alpha-Antagonists; Animals; Clonidine; Dioxanes; In Vitro Techniques; Male | 1982 |
Occurrence of alpha 1s-adrenoceptors in the mouse but not in the rabbit isolated anococcygeus preparations.
Topics: Adrenergic alpha-Agonists; Animals; Clonidine; Drug Interactions; Male; Mice; Muscle Contraction; Mu | 1983 |
In vitro studies with (imidazolinyl-2)-2-benzodioxane-1-4 ((+/-)-170 150), a new potent alpha 2-adrenoceptor blocking agent.
Topics: Adrenergic alpha-Antagonists; Animals; Binding, Competitive; Brain; Clonidine; Dioxins; Idazoxan; In | 1982 |
Studies on RX 781094: a selective, potent and specific antagonist of alpha 2-adrenoceptors.
Topics: Acetylcholine; Adrenergic alpha-Antagonists; Animals; Blood Pressure; Clonidine; Dioxins; Dose-Respo | 1983 |
Role of alpha-2 adrenergic receptors in the control of diarrhea and intestinal motility.
Topics: Administration, Oral; Adrenergic alpha-Agonists; Animals; Antidiarrheals; Clonidine; Dose-Response R | 1983 |
The effect of clonidine on the response to stimulation of non-adrenergic non-cholinergic nerves in the guinea-pig urinary bladder in-vitro.
Topics: Adenosine Triphosphate; Animals; Clonidine; Electric Stimulation; Female; Guinea Pigs; Histamine H1 | 1983 |
Alpha-1 adrenoceptors and calcium in isolated canine coronary arteries.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Calcium; Calcium Channel Blockers; | 1983 |
Interaction of clonidine, its methylene-bridged analog, St 1913, and the benzylic hydroxyl-substituted derivative, St 1965, with alpha 1- and alpha 2-adrenoreceptors.
Topics: Adrenergic alpha-Agonists; Animals; Blood Pressure; Clonidine; Guinea Pigs; Imidazoles; In Vitro Tec | 1983 |
Pre-junctional alpha 2-adrenoceptor activity of B-HT920.
Topics: Adrenergic alpha-Agonists; Animals; Azepines; Clonidine; Dioxanes; Drug Interactions; Guinea Pigs; I | 1983 |
Pyridinylpiperazines, a new class of selective alpha 2-adrenoceptor antagonists.
Topics: Adrenergic alpha-Antagonists; Animals; Cats; Clonidine; Male; Muscle Contraction; Piperazines; Pupil | 1983 |
Demonstration of alpha 1s-adrenoceptors after exposure of the rat anococcygeus to benextramine.
Topics: Adrenergic alpha-Antagonists; Animals; Clonidine; Cystamine; In Vitro Techniques; Male; Muscle Contr | 1983 |
A regional difference in the distribution of postsynaptic alpha-adrenoceptor subtypes in canine veins.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Clonidine; Dogs; Female; In Vitro | 1983 |
Sources of calcium used during alpha 1- and alpha 2-adrenergic contractions in canine saphenous veins.
Topics: Adrenergic alpha-Agonists; Animals; Calcium; Clonidine; Dogs; Dose-Response Relationship, Drug; Fema | 1984 |
Influences on morphine action in the myenteric plexus from guinea pig of alpha 2 receptor stimulation.
Topics: Adrenergic alpha-Agonists; Animals; Clonidine; Drug Synergism; Female; Guanfacine; Guanidines; Guine | 1983 |
Pharmacological characterization of postjunctional alpha-adrenoceptors in isolated human omental arteries and veins.
Topics: Adolescent; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Adult; Aged; Arteries; Clonidin | 1984 |
Assessment of alpha-adrenergic receptor subtypes in isolated rat aortic segments.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Aorta, Thoracic; Azepines; Clonidi | 1984 |
The actions of cirazoline on the rat vas deferens.
Topics: Adrenergic alpha-Agonists; Animals; Clonidine; Imidazoles; In Vitro Techniques; Isometric Contractio | 1984 |
Pre- and postsynaptic alpha-adrenoceptor blocking properties of a new dihydrobenzofurane derivative (imidazolinyl-2)-2-dihydro 2,3 benzofurane (S 9871) and its stereoisomers in rats.
Topics: Adrenergic alpha-Antagonists; Animals; Azepines; Benzofurans; Blood Pressure; Clonidine; Drug Intera | 1984 |
Synthesis and pharmacological evaluation of some WB4101 analogues bearing a naphthodioxanic nucleus.
Topics: Adrenergic alpha-Antagonists; Animals; Chemical Phenomena; Chemistry; Clonidine; Dioxanes; Dioxins; | 1984 |
Alpha 2-adrenoceptor agonists potentiate responses mediated by alpha 1-adrenoceptors in the cat nictitating membrane.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Angiotensin II; Animals; Antihypertensive A | 1984 |
Alpha 1- and alpha 2-adrenoceptors in the smooth muscle of isolated rabbit urinary bladder and urethra.
Topics: Adrenergic alpha-Agonists; Animals; Clonidine; In Vitro Techniques; Male; Muscle Contraction; Muscle | 1984 |
Pharmacological characterization of alpha adrenoceptors in the rat gastric fundus.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Brimonidine Tartrate; Clonidine; E | 1984 |
The action and interaction of beta-phenethylamines and imidazolines on prejunctional alpha 2-adrenoceptors of guinea-pig ileum in the presence of the non-competitive antagonist benextramine.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Azepines; Clonidine; Cystamine; El | 1984 |
Effect of removing the endothelial cells on the reactivity of rat aortic segments to different alpha-adrenoceptor agonists.
Topics: Adrenergic alpha-Agonists; Animals; Aorta, Thoracic; Azepines; Clonidine; Endothelium; Imidazoles; I | 1984 |
Dissociation between endothelium-mediated increases in tissue cGMP levels and modulation of aortic contractile responses.
Topics: Adrenergic alpha-Agonists; Animals; Aorta, Thoracic; Clonidine; Cyclic GMP; Endothelium; Female; In | 1984 |
Effect of clonidine on neuromuscular transmission and the nicotinic acetylcholine receptor.
Topics: Acetylcholinesterase; Adrenergic alpha-Antagonists; Animals; Chickens; Clonidine; Electric Stimulati | 1984 |
Stereospecific blockade of alpha 2-adrenoceptors by (+)-butaclamol: implications for the characterization of dopamine receptors.
Topics: Adrenergic alpha-Antagonists; Animals; Butaclamol; Clonidine; Dibenzocycloheptenes; In Vitro Techniq | 1982 |
Analysis of gait and isokinetic movements for evaluation of antispastic drugs or physical therapies.
Topics: Cerebral Palsy; Clonidine; Electromyography; Gait; Humans; Motor Neurons; Muscle Contraction; Muscle | 1983 |
The role of sodium pump activity in the hyperpolarization and in subsequent depolarization of smooth muscle in response to stimulation of post-synaptic alpha 1-adrenoceptors.
Topics: Animals; Calcium; Clonidine; Colon; Epinephrine; Female; Guinea Pigs; In Vitro Techniques; Male; Mem | 1980 |
Adrenergic mechanisms in canine intralobar pulmonary arteries and veins.
Topics: Animals; Bretylium Compounds; Clonidine; Cocaine; Dogs; Dose-Response Relationship, Drug; Electric S | 1981 |
Effects of metoclopramide and isoprenaline in the rat vas deferens; interactions with alpha-adrenoceptors.
Topics: Animals; Benzamides; Clonidine; Electric Stimulation; In Vitro Techniques; Isoproterenol; Male; Meto | 1980 |
Reversal of alpha 1-receptor mediated relaxation in intestinal smooth muscle.
Topics: Animals; Clonidine; Electrolytes; Female; Guinea Pigs; Intestines; Male; Muscle Contraction; Muscle | 1981 |
Presynaptic dual inhibitory actions of guanabenz on adrenergic transmission.
Topics: Animals; Clonidine; Electric Stimulation; Female; Guanabenz; Guanethidine; Guanidines; Heart Rate; M | 1982 |
Interaction between mianserin and clonidine at alpha 2-adrenoceptors.
Topics: Animals; Blood Pressure; Chickens; Clonidine; Desipramine; Dibenzazepines; Dogs; Drug Interactions; | 1982 |
An in vitro physiological study of normal and unstable human detrusor muscle.
Topics: Acetylcholine; Adult; Aged; Clonidine; Electric Stimulation; Female; Humans; In Vitro Techniques; Is | 1982 |
I. Pharmacological studies with derivatives of 2-aminotetralin, benzhydro[f]quinoline and clonidine suggest a pharmacological identity between peripheral and central alpha-2 adrenoceptors.
Topics: Animals; Clonidine; Guinea Pigs; Ileum; Male; Muscle Contraction; Naphthalenes; Quinolines; Receptor | 1983 |
Effects of 4-chloro-2-(2-imidazolin-2-ylamino)-isoindoline Hydrochloride (BE 6143) at pre- and postsynaptic alpha-adrenoceptors in rabbit aorta and pulmonary artery.
Topics: Animals; Aorta, Thoracic; Clonidine; Electric Stimulation; Female; Imidazoles; In Vitro Techniques; | 1982 |
Action of stereoisomers of (imidazolinyl-2)-2-benzodioxane-1-4 or 2-(2-(1,4-benzodioxanyl))-2-imidazoline (170 150; RX 781094) on peripheral presynaptic and central alpha 2-adrenoceptors.
Topics: Animals; Brain; Chickens; Clonidine; Dioxins; Electric Stimulation; Idazoxan; In Vitro Techniques; M | 1982 |
The role of interaction between opiate receptors and alpha-adrenergic receptors in tolerance and dependence.
Topics: Adenylyl Cyclase Inhibitors; Animals; Brain; Cell Line; Clonidine; Cyclic AMP; Drug Interactions; Dr | 1983 |
Adaptation of a neuron to normorphine and clonidine.
Topics: Acetylcholine; Animals; Cells, Cultured; Clonidine; Drug Tolerance; Electric Stimulation; Guinea Pig | 1983 |
Hypotensive activity of PAF-acether in rats.
Topics: Animals; Blood Pressure; Calcium; Clonidine; Heart Rate; Hypertension; In Vitro Techniques; Male; Mu | 1982 |
Electrophysiological differentiation of alpha-receptors on arteriolar smooth muscle.
Topics: Animals; Arteries; Arterioles; Cats; Clonidine; Electric Conductivity; Female; Male; Membrane Potent | 1983 |
The influence of aging on alpha-adrenoceptors in rat heart and vas deferens.
Topics: Aging; Animals; Clonidine; Heart; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Rat | 1983 |
Comparison of the alpha-adrenoceptor profiles of clonidine and two oxygenated arylamino imidazolines.
Topics: Animals; Blood Pressure; Clonidine; Electric Stimulation; Ileum; In Vitro Techniques; Male; Muscle C | 1983 |
Alpha adrenergic receptor subtype associated with receptor binding, Ca++ influx, Ca++ release and contractile events in the rabbit aorta.
Topics: Animals; Aorta; Calcium; Clonidine; Ion Channels; Muscle Contraction; Muscle, Smooth, Vascular; Nore | 1983 |
[Characteristics of alpha adrenoceptors of lymphatics and their physiological significance].
Topics: Animals; Binding, Competitive; Cattle; Clonidine; In Vitro Techniques; Lymphatic System; Mesentery; | 1983 |
Interaction between 2-chloroadenosine and alpha-adrenoceptors in rat vas deferens.
Topics: 2-Chloroadenosine; Adenosine; Animals; Clonidine; Electric Stimulation; In Vitro Techniques; Male; M | 1984 |
In vitro selectivity of lisuride and other ergot derivatives for alpha 1- and alpha 2-adrenoceptors.
Topics: Animals; Bromocriptine; Clonidine; Dose-Response Relationship, Drug; Ergolines; Ergot Alkaloids; Gui | 1984 |
Mouse uterine muscle as a model for studying beta 2-adrenoreceptor mediated relaxation.
Topics: Animals; Clonidine; Epinephrine; Estrus; Female; In Vitro Techniques; Isoproterenol; Mice; Models, B | 1984 |
Actions of tizanidine on alpha 1-and alpha 2-adrenoceptors in the peripheral tissues.
Topics: Animals; Aorta, Thoracic; Clonidine; Female; Guinea Pigs; Ileum; In Vitro Techniques; Male; Muscle C | 1984 |
Action of tizanidine on responses of forearm flexors and extensors to torque disturbances.
Topics: Adult; Blood Pressure; Clonidine; Electromyography; Female; Forearm; Humans; Male; Muscle Contractio | 1984 |
Pertussis toxin blocks the action of morphine, norepinephrine and clonidine on isolated guinea-pig ileum.
Topics: Adenylate Cyclase Toxin; Animals; Bacterial Toxins; Clonidine; Electric Stimulation; Guinea Pigs; Il | 1984 |
Effect of pertussis toxin on normorphine-dependence and on acute inhibitory effects of normorphine and clonidine in guinea-pig isolated ileum.
Topics: Adenylate Cyclase Toxin; Animals; Bacterial Toxins; Clonidine; Guinea Pigs; Ileum; In Vitro Techniqu | 1984 |
The effects of clonidine on electrically-induced contractions of rat detrusor strips in vitro.
Topics: Acetylcholine; Animals; Atropine; Clonidine; Electric Stimulation; In Vitro Techniques; Male; Muscle | 1983 |
Effect of islet-activating protein (IAP) on contractile responses of rat vas deferens: evidence for participation of Ni (inhibitory GTP binding regulating protein) in the alpha 2-adrenoceptor-mediated response.
Topics: Adenylate Cyclase Toxin; Adenylyl Cyclases; Animals; Bacterial Proteins; Clonidine; Electric Stimula | 1983 |
Enhanced responsiveness of rat isolated aorta to clonidine after removal of the endothelial cells.
Topics: Animals; Aorta, Thoracic; Calcium Channel Blockers; Clonidine; Endothelium; In Vitro Techniques; Mal | 1984 |
Different effects of phenylephrine and clonidine on 86Rb efflux and on contraction in the rat caudal artery.
Topics: Animals; Clonidine; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth, Vascular; Phenyle | 1984 |
Changes in sensitivity to the inhibitory effects of adrenergic agonists on intestinal motor activity after chronic sympathetic denervation.
Topics: Acetylcholine; Animals; Carbachol; Clonidine; Gastrointestinal Motility; Guinea Pigs; In Vitro Techn | 1984 |
Factors influencing the release of purines and norepinephrine in the rabbit portal vein.
Topics: Adrenergic Fibers; Animals; Clonidine; Electric Stimulation; Hydroxydopamines; In Vitro Techniques; | 1982 |
Effect of clonidine on the chronic morphine tolerance and on the sensitivity of the smooth muscles in mice.
Topics: Acetylcholine; Analgesia; Animals; Clonidine; Drug Interactions; Drug Tolerance; Ileum; Male; Mice; | 1983 |
Characteristics of lofexidine in pharmacological screening.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Cats; Clonidine; Coronary Circulation; Dogs; Hemod | 1982 |
Castration alters the stimulatory and inhibitory adrenergic influences on isolated rat vas deferens.
Topics: Animals; Castration; Clonidine; Ethanolamines; In Vitro Techniques; Male; Muscle Contraction; Norepi | 1981 |
Muscle restraint in speed controlled voluntary and passive movements.
Topics: Clonidine; Electromyography; Humans; Knee; Leg; Movement; Muscle Contraction; Muscles; Paresis; Refl | 1982 |
[Studies on the antinociceptive activity of guanabenz, with particular reference to clonidine and morphine (author's transl)].
Topics: Analgesics; Animals; Clonidine; Dose-Response Relationship, Drug; Female; Guanabenz; Guanidines; Gui | 1982 |
Development of clonidine-tolerance in the rat vas deferens: cross tolerance to other presynaptic inhibitory agents.
Topics: Adenosine; Animals; Azepines; Clonidine; Drug Tolerance; Endorphins; Evoked Potentials; Male; Methox | 1982 |
Pharmacology of B-HT 920 in some isolated smooth muscles of the guinea-pig.
Topics: Animals; Aorta; Azepines; Clonidine; Dogs; Drug Interactions; Ileum; In Vitro Techniques; Male; Musc | 1982 |
Characteristics of oscillatory contractions elicited by naloxone in ileum preparation from morphine-dependent guinea pigs.
Topics: Acetylcholine; Animals; Clonidine; Guinea Pigs; Humans; Ileum; In Vitro Techniques; Male; Morphine D | 1980 |
Clonidine dependence in the guinea-pig isolated ileum.
Topics: Animals; Clonidine; Guinea Pigs; Humans; Ileum; In Vitro Techniques; Male; Morphine Derivatives; Mus | 1981 |
Pre- and postjunctional effects of clonidine- and oxymetazoline-like compounds in guinea-pig ileal preparations.
Topics: Acetylcholine; Animals; Clonidine; Electric Stimulation; Guinea Pigs; Ileum; Imidazoles; In Vitro Te | 1981 |
Influence of clonidine on the acute tolerance pattern to morphine induced analgesia and sensitivity changes in mice.
Topics: Analgesics; Animals; Clonidine; Drug Interactions; Drug Tolerance; Male; Mice; Morphine; Muscle Cont | 1981 |
Effects of clonidine on aortic elastic modulus and aortic stress in anesthetized rabbits.
Topics: Animals; Aorta; Blood Pressure; Clonidine; Elasticity; Muscle Contraction; Muscle Relaxation; Rabbit | 1981 |
The histamine-like effects of tolazoline and clonidine:: evidence against direct activity at histamine receptors.
Topics: Animals; Clonidine; Guinea Pigs; Heart Rate; Histamine; In Vitro Techniques; Male; Muscle Contractio | 1981 |
Facilitation by clonidine of purine release induced by high KCl from the rabbit pulmonary artery.
Topics: Adenosine; Animals; Clonidine; Denervation; Epinephrine; In Vitro Techniques; Male; Muscle Contracti | 1981 |
Role of L-type calcium channels on yohimbine-precipitated clonidine withdrawal in vivo and in vitro.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1993 |
The role of calcium and alpha-adrenoceptors in contractile response of chick expansor secundariorum muscle to field stimulation.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1994 |
Effects of clonidine on the reflex cardiovascular responses and release of substance P during muscle contraction.
Topics: Analysis of Variance; Animals; Blood Pressure; Cats; Clonidine; Dose-Response Relationship, Drug; El | 1994 |
Signal transducing mechanisms coupled to histamine H3 receptors and alpha-2 adrenoceptors in the guinea pig duodenum: possible involvement of N-type Ca++ channels.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1994 |
Pharmacological characterization of alpha 1-adrenoceptor subtypes in the human prostate: functional and binding studies.
Topics: Adrenergic alpha-Antagonists; Binding, Competitive; Clonidine; Dioxanes; Dose-Response Relationship, | 1994 |
Effects of alpha 2-adrenergic receptor agonist and antagonist drugs on cholinergic contraction in bovine tracheal smooth muscle in vitro.
Topics: Acetylcholine; Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Adrene | 1995 |
Evidence for a functional alpha 1A- (alpha 1C-) adrenoceptor mediating contraction of the rat epididymal vas deferens and an alpha 1B-adrenoceptor mediating contraction of the rat spleen.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Binding, Competitive; Clonidine; C | 1995 |
Alpha 1A-adrenoceptor subtype effectively increases Ca(2+)-sensitivity for contraction in rabbit thoracic aorta.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Alkaloids; Animals; Aorta, Thoracic; Calciu | 1995 |
Differential inhibition in the human vas deferens by phenoxybenzamine: a possible mechanism for its contraceptive action.
Topics: Adrenergic alpha-Antagonists; Calcium; Clonidine; Contraceptive Agents, Male; Cystamine; Humans; In | 1995 |
Visceral antinociceptive effects of spinal clonidine combined with morphine, [D-Pen2, D-Pen5] enkephalin, or U50,488H.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics | 1995 |
Role of the epithelium in the release of contractile agents from the rat vas deferens by clonidine.
Topics: Animals; Biological Factors; Clonidine; Epithelium; Female; In Vitro Techniques; Male; Microscopy, E | 1995 |
Differential inhibition of cholinergic and noncholinergic neurogenic contractions by mu opioid and alpha-2 adrenergic agonists in guinea pig ileum.
Topics: Acetylcholine; Adrenergic alpha-Agonists; Animals; Brimonidine Tartrate; Choline; Clonidine; Enkepha | 1993 |
A preliminary investigation of the mechanisms underlying cannabinoid tolerance in the mouse vas deferens.
Topics: Adenosine Triphosphate; Animals; Arachidonic Acids; Clonidine; Dose-Response Relationship, Drug; Dow | 1995 |
Alpha 1-adrenoceptor responsiveness in the aging aorta.
Topics: Adrenergic alpha-Antagonists; Aging; Analysis of Variance; Animals; Aorta; Binding, Competitive; Clo | 1995 |
Mediation of noradrenaline-induced contractions of rat aorta by the alpha 1B-adrenoceptor subtype.
Topics: Adrenergic alpha-Antagonists; Animals; Aorta, Thoracic; Binding, Competitive; Clonidine; Computer Si | 1995 |
Effects of nifedipine on phasic and tonic vasoconstrictor responses to Sgd 101/75 in the isolated perfused rabbit ear artery.
Topics: Adrenergic alpha-Agonists; Animals; Arteries; Calcium; Clonidine; Ear; Muscle Contraction; Muscle, S | 1994 |
Constipation evoked by 5-HT3-receptor antagonism: evidence for heterogeneous efficacy among different antagonists in guinea-pigs.
Topics: Animals; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Clonidine; Colon; Const | 1994 |
Effects of atropine, pirenzepine, clonidine, and morphine on biphasic response of rat gastric fundus to field stimulation.
Topics: Animals; Atropine; Clonidine; Dose-Response Relationship, Drug; Electric Stimulation; Gastric Fundus | 1994 |
Pharmacological evidence of distinct alpha 1-adrenoceptor subtypes mediating the contraction of human prostatic urethra and peripheral artery.
Topics: Aged; Aged, 80 and over; Arteries; Clonidine; Dioxanes; Dose-Response Relationship, Drug; Humans; In | 1994 |
Alpha 1A-adrenoceptor subtype mediates contraction of the rat urethra.
Topics: Aminoquinolines; Animals; Calcium; Clonidine; Dioxanes; Dose-Response Relationship, Drug; Idazoxan; | 1994 |
Functional identification of alpha 1-adrenoceptor subtypes in human prostate: comparison with those in rat vas deferens and spleen.
Topics: Adrenergic alpha-Antagonists; Aged; Aged, 80 and over; Animals; Clonidine; Dose-Response Relationshi | 1994 |
In vitro studies of release of adenine nucleotides and adenosine from rat vascular endothelium in response to alpha 1-adrenoceptor stimulation.
Topics: Adenine Nucleotides; Adenosine; Adenosine Triphosphate; Adrenergic alpha-1 Receptor Agonists; Animal | 1994 |
Interactions of chloroethylclonidine with rauwolscine- and prazosin-sensitive adrenoceptors in dog saphenous vein.
Topics: Adrenergic alpha-1 Receptor Antagonists; Adrenergic beta-Antagonists; Animals; Calcium; Calcium Chan | 1994 |
Chloroethylclonidine irreversibly activates postjunctional alpha 2-adrenoceptors in the dog saphenous vein.
Topics: Adrenergic alpha-Agonists; Alkylating Agents; Animals; Brimonidine Tartrate; Clonidine; Cocaine; Dog | 1993 |
Characterization of alpha 1-adrenoceptor subtypes in prostate and prostatic urethra of rat, rabbit, dog and man.
Topics: Adrenergic alpha-Antagonists; Alkylating Agents; Animals; Binding Sites; Clonidine; Dogs; Humans; Ma | 1993 |
Characterization of the alpha 1-adrenoceptors of the rat prostate gland.
Topics: Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-Antagonists; Alkylating Agents; Animals; C | 1993 |
Aminophylline preferentially inhibits chloroethylclonidine-insensitive alpha-adrenoceptor-mediated contractions in rat aorta.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Aminophylline; Animals; Aorta, Thoracic; Ca | 1993 |
Colonic giant migrating contractions induced by glycerol enema in anesthetized rats.
Topics: Animals; Atropine; Catheterization; Clonidine; Colon; Enema; Ganglionic Blockers; Gastrointestinal M | 1993 |
Functional distribution and role of alpha-1 adrenoceptor subtypes in the mesenteric vasculature of the rat.
Topics: Adrenergic alpha-Antagonists; Animals; Calcium; Clonidine; In Vitro Techniques; Male; Mesenteric Art | 1994 |
Functional studies on alpha 1-adrenoceptor subtypes mediating inotropic effects in rat right ventricle.
Topics: Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; An | 1994 |
Identification of the mRNA for the novel alpha 1D-adrenoceptor and two other alpha 1-adrenoceptors in vascular smooth muscle.
Topics: Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-Antagonists; Animals; Clonidine; In Situ H | 1994 |
Alpha 1-adrenoceptor subtype(s) mediating noradrenaline-induced contractions of the guinea-pig aorta.
Topics: Adrenergic alpha-1 Receptor Agonists; Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-Agon | 1994 |
A heterogeneous population of alpha 1 adrenergic receptors mediates contraction of human corpus cavernosum smooth muscle to norepinephrine.
Topics: Alkylating Agents; Clonidine; Humans; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; | 1995 |
Effects of omega-conotoxin GVIA on electrical field stimulation- and agonist-induced changes in cytosolic Ca2+ and tension in isolated rat anococcygeus muscle.
Topics: Animals; Calcium; Calcium Channel Blockers; Clonidine; Cytosol; Dose-Response Relationship, Drug; El | 1994 |
Chloroethylclonidine: an irreversible agonist at prejunctional alpha 2-adrenoceptors in rat vas deferens.
Topics: Adrenergic alpha-Agonists; Animals; Clonidine; Male; Muscle Contraction; Muscle, Smooth; Neuromuscul | 1993 |
A model system to determine the effects of specific neurotransmitters on segmental reflexes in the spinal cord of the rat.
Topics: Animals; Clonidine; Decerebrate State; Dopamine; Electromyography; Electrophysiology; Female; Hindli | 1993 |
Pharmacological characterization of two distinct alpha 1-adrenoceptor subtypes in rabbit thoracic aorta.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Aorta, Thoracic; Binding, Competit | 1993 |
Inhibition by alpha 2-adrenoceptor agonists of contractions of rabbit isolated colon elicited by pelvic nerve stimulation.
Topics: Acetylcholine; Adrenergic alpha-Agonists; Animals; Atropine; Clonidine; Colon; Drug Resistance; Imid | 1993 |
Structure-activity relationships in 1,4-benzodioxan-related compounds. 4. Effect of aryl and alkyl substituents at position 3 on alpha-adrenoreceptor blocking activity.
Topics: Adrenergic alpha-Antagonists; Animals; Clonidine; Dioxanes; In Vitro Techniques; Male; Muscle Contra | 1993 |
The alpha-adrenoceptor subtype mediating the tension of human prostatic smooth muscle.
Topics: Adrenergic alpha-Antagonists; Aged; Aged, 80 and over; Binding, Competitive; Clonidine; Dioxanes; Do | 1993 |
Relation between alpha 1-adrenoceptor subtypes and noradrenaline-induced contraction in rat portal vein smooth muscle.
Topics: Acetonitriles; Adrenergic alpha-Antagonists; Alkylating Agents; Animals; Clonidine; Dioxanes; Horses | 1993 |
Verongamine, a novel bromotyrosine-derived histamine H3-antagonist from the marine sponge Verongula gigantea.
Topics: Animals; Clonidine; Guinea Pigs; Histamine Antagonists; In Vitro Techniques; Magnetic Resonance Spec | 1994 |
The alpha 1-adrenergic receptor that mediates smooth muscle contraction in human prostate has the pharmacological properties of the cloned human alpha 1c subtype.
Topics: Animals; CHO Cells; Clonidine; Cricetinae; Humans; Male; Muscle Contraction; Muscle, Smooth; Phenyle | 1994 |
Effects of subchronic exposure of rats to lead or zinc on alpha-adrenoceptor-mediated contractile responses in isolated vas deferens.
Topics: Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-2 Receptor Antagonists; Animals; Clonidine | 1993 |
Age-related changes in norepinephrine release and its modulation by presynaptic alpha-2 adrenoceptors in the rat vas deferens.
Topics: Aging; Animals; Clonidine; Electric Stimulation; Epididymis; Estradiol; In Vitro Techniques; Male; M | 1993 |
Involvement of alpha-adrenoceptors in the endothelium-dependent depression of noradrenaline-induced contraction in rat aorta.
Topics: Animals; Aorta, Thoracic; Arginine; Clonidine; Dose-Response Relationship, Drug; Endothelium, Vascul | 1993 |
Alpha 1-adrenoceptor subtypes mediating the norepinephrine-induced contractile response in the rat vas deferens.
Topics: Adrenergic alpha-1 Receptor Antagonists; Alkylating Agents; Animals; Clonidine; Epididymis; In Vitro | 1993 |
Evidence for functional dissociation of dependence and tolerance in guinea-pig isolated ileal segments following 20 hour exposure to morphine in vitro.
Topics: Animals; Clonidine; Drug Tolerance; Female; Guinea Pigs; Ileum; In Vitro Techniques; Male; Morphine; | 1993 |
Vaccination with live Pasteurella haemolytica alters vascular adrenergic reactivity.
Topics: Animals; Aorta; Bacterial Vaccines; Clonidine; Isoproterenol; Male; Mannheimia haemolytica; Muscle C | 1993 |
Withdrawal contractures of guinea-pig isolated ileum after acute activation of kappa-opioid receptors.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics | 1993 |
In vitro effects of alpha 2-adrenergic receptor stimulation on cholinergic contractions of equine distal airways.
Topics: Acetylcholine; Animals; Bronchi; Clonidine; Electric Stimulation; Horses; In Vitro Techniques; Muscl | 1993 |
Effect of naringin and naringenin on contractions induced by noradrenaline in rat vas deferens--I. Evidence for postsynaptic alpha-2 adrenergic receptor.
Topics: Animals; Clonidine; Flavanones; Flavonoids; In Vitro Techniques; Male; Muscle Contraction; Muscle, S | 1993 |
Investigation of the actions of chloroethylclonidine in rat aorta.
Topics: Adrenergic alpha-Antagonists; Analysis of Variance; Animals; Aorta; Clonidine; Cystamine; Dioxanes; | 1995 |
Alpha 1A-adrenoceptor-mediated contractile responses of the human vas deferens.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Adult; Binding, Competitive; Calcium; Cloni | 1995 |
Mechanisms involved in electrically-induced responses of rat seminal vesicles.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Atropine; Carbachol; Clonidine; El | 1995 |
Effect of cyclosporin A on isolated rabbit bladder and urethral smooth muscle.
Topics: Acetylcholine; Animals; Clonidine; Cyclosporine; Dose-Response Relationship, Drug; Female; In Vitro | 1996 |
Clonidine-induced rhythmic activity in rabbit anococcygeus muscle.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-Agonists; Adrenergic Uptake Inhibitors; Anima | 1996 |
Unusual alpha-adrenoceptor subtype in canine saphenous vein: comparison to mesenteric vein.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Binding, Competitive; Clonidine; D | 1996 |
Further characterization of antagonism by alpha 2-adrenoceptor agonists of contractions induced by alpha 1-adrenoceptor agonists.
Topics: Adrenergic alpha-1 Receptor Agonists; Adrenergic alpha-2 Receptor Agonists; Animals; Aorta; Arteries | 1996 |
Different alpha1-adrenoceptor subtypes mediate contraction in rabbit aorta and urethra.
Topics: Animals; Aorta; Clonidine; Dose-Response Relationship, Drug; Kinetics; Male; Muscle Contraction; Nor | 1995 |
Functional properties of agmatine in rat vas deferens.
Topics: Agmatine; Animals; Clonidine; Electric Stimulation; In Vitro Techniques; Male; Muscle Contraction; M | 1996 |
Rilmenidine activates postjunctional alpha 1- and alpha 2-adrenoceptors in the canine saphenous vein.
Topics: Adrenergic alpha-1 Receptor Agonists; Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-Agonist | 1996 |
Regulation of soleus muscle spindle sensitivity in decerebrate and spinal cats during postural and locomotor activities.
Topics: Action Potentials; Afferent Pathways; Animals; Cats; Clonidine; Decerebrate State; Electrophysiology | 1996 |
Functional evidence for an alpha 1B-adrenoceptor mediating contraction of the mouse spleen.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Clonidine; Dose-Response Relations | 1996 |
Effects of optical isomers of ephedrine and methylephedrine on the twitch response in the isolated rat vas deferens and the involvement of alpha 2-adrenoceptors.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Animals; Clonidine; D | 1996 |
Hypoxia/reoxygenation selectively impairs alpha 1b-adrenoceptor function in small mesenteric arteries.
Topics: Adrenergic alpha-Antagonists; Aerobiosis; Animals; Catalase; Clonidine; Dioxanes; Hypoxia; In Vitro | 1996 |
A simple method for measuring the effects of drugs on intestinal longitudinal and circular muscle.
Topics: Animals; Atropine; Brimonidine Tartrate; Clonidine; Electric Stimulation; Female; Guinea Pigs; Hexam | 1996 |
Inhibitory effect of mitragynine, an alkaloid with analgesic effect from Thai medicinal plant Mitragyna speciosa, on electrically stimulated contraction of isolated guinea-pig ileum through the opioid receptor.
Topics: Acetylcholine; Analgesics; Animals; Clonidine; Diterpene Alkaloids; Electric Stimulation; Guinea Pig | 1997 |
alpha1-Adrenoceptor subtypes mediating the contraction of arteries in spontaneously hypertensive rats.
Topics: Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; An | 1995 |
Intracellular Ca2+ and contractile responses to alpha 1-adrenoceptor subtype activation in rat aortic vascular smooth muscle.
Topics: Adrenergic alpha-1 Receptor Agonists; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Anima | 1997 |
Alpha 1D- and alpha 1A-adrenoceptors mediate contraction in rat renal artery.
Topics: Animals; Clonidine; Male; Muscle Contraction; Norepinephrine; Piperazines; Rats; Rats, Wistar; Recep | 1997 |
Heterogeneity and complexity of alpha 1-adrenoceptors in the ovine uterine artery and umbilical vein.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Arteries; Binding, Competitive; Ca | 1997 |
Inhibition of contractions by tricyclic antidepressants and xylamine in rat vas deferens.
Topics: Adenosine Triphosphate; Animals; Antidepressive Agents, Tricyclic; Barium Compounds; Calcium; Chlori | 1997 |
Functional change of the balance between alpha 1A and alpha 1B adrenoceptor populations after transplantation of the vas deferens to the intestine.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Calcium Channel Blockers; Clonidin | 1997 |
Subtyping of alpha1-adrenoceptors responsible for the contractile response in the rat corpus cavernosum.
Topics: Adrenergic alpha-1 Receptor Agonists; Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-Agon | 1997 |
[Effect of extracellular Na+ on the alpha-1-adrenergic contractile reaction of the rat vas deferens].
Topics: Adrenergic alpha-Agonists; Animals; Clonidine; Extracellular Space; Male; Methoxamine; Muscle Contra | 1997 |
Characterisation of pre- and post-synaptic alpha-adrenoceptors in modulation of the rat ileum longitudinal and circular muscle activities.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Binding Sites; Brimonidine Tartrat | 1997 |
Evidence that methyl arachidonyl fluorophosphonate is an irreversible cannabinoid receptor antagonist.
Topics: Animals; Arachidonic Acids; Clonidine; Dose-Response Relationship, Drug; Dronabinol; Guinea Pigs; In | 1997 |
Chloroethylclonidine and alpha-adrenoceptor agonist interaction in blood vessels following heart failure.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Arteries; Clonidine; Dogs; Dose-Re | 1997 |
Enhanced alpha2A-autoreceptor reserve for clonidine induced by reserpine and cholinomimetic agents in the rat vas deferens.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Autoreceptors; Clonidine; Dose-Res | 1997 |
Characterization of alpha-adrenoceptors in canine mesenteric vein.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Binding, Competitive; Clonidine; D | 1997 |
Expression and function of alpha1-adrenoceptor subtypes in the porcine renal artery.
Topics: Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Am | 1998 |
Alteration of alpha1-adrenoceptor subtypes in aortas of 12-month-old spontaneously hypertensive rats.
Topics: Adrenergic alpha-Antagonists; Animals; Aorta; Clonidine; Dioxanes; Hypertension; Indoles; Male; Musc | 1998 |
Drug induced contraction and relaxation in mouse isolated aorta.
Topics: 1-Methyl-3-isobutylxanthine; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Aorta | 1997 |
alpha1-Adrenoceptor-mediated phosphorylation of myosin in rat-tail arterial smooth muscle.
Topics: Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; An | 1997 |
Functional effects of castration on alpha1-adrenoceptors in rat vas deferens.
Topics: Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-Antagonists; Animals; Castration; Clonidin | 1998 |
Discrimination of alpha1-adrenoceptor subtypes in rat aorta and prostate.
Topics: Acetonitriles; Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-Antagonists; Animals; Aorta | 1998 |
Selective potentiation by ouabain of naloxone-induced withdrawal contractions of isolated guinea-pig ileum following acute exposure to morphine.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Carbachol; Clonidine; Drug Synergi | 1998 |
Mechanism of relaxant effect of clonidine in isolated bovine tracheal smooth muscle.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Calcium; Cattle; Clonidine; Cyclic | 1998 |
Chloroethylclonidine is a partial alpha1-adrenoceptor agonist in aorta and caudal arteries of the Wistar Kyoto rat.
Topics: Adrenergic alpha-1 Receptor Agonists; Adrenergic alpha-Antagonists; Animals; Aorta; Clonidine; Dose- | 1998 |
Distribution, tolerability and tissue compatibility of intrathecal tizanidine in the sheep.
Topics: Adrenergic alpha-Agonists; Analgesia, Epidural; Analgesics; Analgesics, Opioid; Animals; Behavior, A | 1998 |
Effects of the selective cyclooxygenase-2 inhibitor nimesulide on vascular contractions in endothelium-denuded rat aorta.
Topics: Animals; Aorta; Bridged Bicyclo Compounds, Heterocyclic; Clonidine; Cyclooxygenase 2; Cyclooxygenase | 1998 |
Dopamine releases endothelium-derived relaxing factor via alpha 2-adrenoceptors in canine vessels: comparisons between femoral arteries and veins.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Clonidine; Dogs; Dopamine; Drug In | 1998 |
Rilmenidine reveals differences in the pharmacological characteristics of prejunctional alpha2-adrenoceptors in the guinea-pig, rat and pig.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Agon | 1998 |
Effects of EM574 and cisapride on gastric contractile and emptying activity in normal and drug-induced gastroparesis in dogs.
Topics: Animals; Cisapride; Clonidine; Dogs; Erythromycin; Gastric Emptying; Gastrointestinal Agents; Gastro | 1998 |
Functional characterization of alpha1-adrenoceptor subtypes in longitudinal and circular muscle of human vas deferens.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Adult; Alkylating Agents; Binding, Competit | 1999 |
The role of alpha1-adrenoceptors in the clonidine-induced contraction and relaxation of rat aorta.
Topics: Adrenergic alpha-1 Receptor Agonists; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Anima | 1998 |
Gender differences in the endothelial regulation of alpha2-adrenoceptor-mediated contraction in the rat aorta.
Topics: Adrenergic alpha-Agonists; Animals; Aorta, Thoracic; Castration; Clonidine; Endothelium, Vascular; E | 1999 |
Preconditioning prevents the negative inotropic action of phenylephrine in rat isolated stunned papillary muscle.
Topics: Adrenergic alpha-Antagonists; Animals; Cardiotonic Agents; Clonidine; Dioxanes; Female; Ischemic Pre | 1999 |
Characterization of alpha1-adrenoceptor subtypes mediating noradrenaline-induced contraction of rat epididymal vas deferens in calcium-free medium.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Calcium; Citric Acid Cycle; Clonid | 1999 |
Evaluation of alpha1-adrenoceptors in the rabbit iris: pharmacological characterization and expression of mRNA.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Binding, Competitive; Clonidine; D | 1999 |
Effects of some imidazolidine alpha2-adrenoceptor agonists in rat isolated atria.
Topics: Adrenergic alpha-Agonists; Animals; Brimonidine Tartrate; Clonidine; Drug Interactions; Electric Sti | 1999 |
Expression and pharmacological characterization of alpha1-adrenoceptors in rat seminal vesicle.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Calcium Channel Blockers; Clonidin | 1999 |
Differential response to chloroethylclonidine in blood vessels of normotensive and spontaneously hypertensive rats: role of alpha 1D- and alpha 1A-adrenoceptors in contraction.
Topics: Adrenergic alpha-Antagonists; Animals; Aorta; Clonidine; In Vitro Techniques; Male; Muscle Contracti | 2000 |
Successful treatment of reflex sympathetic dystrophy by bier block with lidocaine and clonidine.
Topics: Adult; Anesthesia, Conduction; Anesthetics, Local; Cardiography, Impedance; Clonidine; Female; Human | 1999 |
The mechanisms of alpha(2)-adrenoceptor agonist-induced contraction in longitudinal muscle of the porcine uterus.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-Agonists; Animals; Brimonidine Tartrate; Calc | 2000 |
Effect of aspirin on the contractility of aortic smooth muscle and the course of blood pressure development in male spontaneously hypertensive rats.
Topics: Animals; Aorta; Arachidonic Acids; Aspirin; Blood Pressure; Calcium; Calcium Signaling; Cell Membran | 1998 |
Clonidine induces upper airway closure in awake goats.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Apnea; Benzazepines; Clonidine; Co | 2000 |
Comparison of contractile responses relative to protein between isolated diabetic and non-diabetic rat aortae to KCl and alpha-adrenoceptor agonists in different extracellular calcium concentrations.
Topics: Adrenergic alpha-Agonists; Animals; Aorta, Thoracic; Calcium; Clonidine; Diabetes Mellitus, Experime | 2000 |
Clonidine attenuates the carbachol-induced contractile and phosphatidylinositol responses of rat trachea.
Topics: Aluminum Compounds; Analgesics; Animals; Carbachol; Clonidine; Dose-Response Relationship, Drug; Flu | 2000 |
Effects of adrenergic alpha2-receptor agonists on urinary bladder contraction in conscious rats.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-Agonists; Animals; Clonidine; Male; Muscle Co | 2000 |
Inositolphosphate formation in thoracic and abdominal rat aorta following Gq/11-coupled receptor stimulation.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adrenergic alpha-Agonists; Adren | 2001 |
Intracellular alkalinization augments alpha(1)-adrenoceptor-mediated vasoconstriction by promotion of Ca(2+) entry through the non-L-type Ca(2+) channels.
Topics: Adrenergic alpha-Agonists; Ammonium Chloride; Animals; Aorta; Calcium; Calcium Channel Blockers; Cal | 2001 |
Inhibition by clonidine of the carbachol-induced tension development and nonselective cationic current in guinea pig ileal myocytes.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Calcium Channels; Carbachol; Cloni | 2001 |
Agmatine, an endogenous ligand at imidazoline binding sites, does not antagonize the clonidine-mediated blood pressure reaction.
Topics: Adrenergic alpha-Agonists; Agmatine; Animals; Aorta, Thoracic; Binding Sites; Blood Pressure; Clonid | 2002 |
Dual alpha(2)-adrenergic agonist and alpha(1)-adrenergic antagonist actions of dexmedetomidine on human isolated endothelium-denuded gastroepiploic arteries.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Anta | 2002 |
Chloride increases adrenergic receptor-mediated platelet and vascular responses.
Topics: Adrenergic alpha-Agonists; Animals; Benzothiadiazines; Blood Platelets; Carbonic Anhydrases; Chlorid | 2002 |
Relative pre- and postsynaptic potencies of alpha-adrenoceptor agonists in the rabbit pulmonary artery.
Topics: Adrenergic alpha-Agonists; Animals; Clonidine; Dose-Response Relationship, Drug; Electric Stimulatio | 1975 |
Pharmacological characterisation of the presynaptic alpha-adrenoceptor in the rat vas deferens.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Clonidine; Electric Stimulation; I | 1977 |
Selectivity of blocking agents for pre-and postsynaptic alpha-adrenoceptors.
Topics: Adrenergic alpha-Antagonists; Animals; Clonidine; In Vitro Techniques; Male; Muscle Contraction; Mus | 1977 |
Inhibitory effects of clonidine on responses to sympathetic nerve stimulation in the pithed rat.
Topics: Adrenergic alpha-Agonists; Animals; Blood Pressure; Clonidine; Dose-Response Relationship, Drug; Ele | 1977 |
A comparative study on the pre- and post-synaptic alpha blocking activity of a series of benzodioxanes.
Topics: Adrenergic alpha-Antagonists; Animals; Clonidine; In Vitro Techniques; Male; Muscle Contraction; Phe | 1978 |
Pharmacological characterization of the presynaptic alpha-adrenoceptors regulating cholinergic activity in the guinea-pig ileum.
Topics: Acetylcholine; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Clonidine; Drug Int | 1978 |
Partial agonist of clonidine on prejunctional and postjunctional alpha-adrenoceptors.
Topics: Adrenergic alpha-Agonists; Animals; Aorta, Thoracic; Clonidine; Female; In Vitro Techniques; Male; M | 1978 |
Blockade by WB 4101 of alpha-adrenoceptors in the rat vas deferens and guinea-pig taenia caeci.
Topics: Adrenergic alpha-Antagonists; Animals; Cecum; Clonidine; Dioxanes; Dioxins; Guinea Pigs; In Vitro Te | 1978 |
Pre- and postsynaptic effects of alpha-agonists in the anococcygeus muscle of the pithed rat.
Topics: Adrenalectomy; Adrenergic alpha-Agonists; Animals; Clonidine; Male; Muscle Contraction; Muscle, Smoo | 1979 |
The inhibitory effects of presynaptic alpha-adrenoceptor agonists on contractions of guinea-pig ileum and mouse vas deferens in the morphine-dependent and withdrawn states produced in vitro.
Topics: Adenosine Diphosphate; Adrenergic alpha-Agonists; Animals; Clonidine; Drug Implants; Drug Interactio | 1979 |
Antagonistic effects of synthetic alpha adrenoceptor agonists on isolated artery strips from the cod, Gadus morhua.
Topics: Adrenergic alpha-Agonists; Animals; Clonidine; Dose-Response Relationship, Drug; Drug Therapy, Combi | 1979 |
Presynaptic alpha-adrenoceptor blocking properties among tri- and tetra-cyclic antidepressant drugs.
Topics: Adrenergic alpha-Antagonists; Animals; Antidepressive Agents; Antidepressive Agents, Tricyclic; Clon | 1979 |
Inhibitory effects of imidazolines on histamine liberation from human leukocytes and on tracheal smooth muscle tone.
Topics: Animals; Cattle; Cimetidine; Clemastine; Clonidine; Guinea Pigs; Histamine H1 Antagonists; Histamine | 1978 |
Possible involvement of endogenous histamine in the myotropic effect of clonidine on the isolated rabbit aorta.
Topics: Amine Oxidase (Copper-Containing); Animals; Aorta, Thoracic; Blood Vessels; Clonidine; Female; Hista | 1978 |
Reversible depression of electrically-induced contractions of guinea pig longitudinal muscle by a reversible inhibitor of prostaglandin synthetase.
Topics: Amidines; Animals; Chlorphenamidine; Clonidine; Cyclooxygenase Inhibitors; Guinea Pigs; Indomethacin | 1979 |
Inhibitory effect of clonidine on a peripheral adrenergic synapse [proceedings].
Topics: Animals; Clonidine; Depression, Chemical; Electric Stimulation; In Vitro Techniques; Male; Muscle Co | 1976 |
Inhibition by alpha- and beta-adrenoceptors of the twitch response to transmural stimulation in the guinea-pig vas deferens.
Topics: Animals; Clonidine; Guinea Pigs; Isoproterenol; Male; Methoxamine; Muscle Contraction; Neuromuscular | 1976 |
A system for measuring the noradrenaline receptor contribution to the flexor reflex.
Topics: Animals; Clonidine; Dose-Response Relationship, Drug; Electric Stimulation; Levodopa; Male; Muscle C | 1976 |
Influence of apomorphine on sympathetic neural transmission in the nictitating membrane of the cat.
Topics: Animals; Apomorphine; Cats; Clonidine; Dopamine; Haloperidol; Muscle Contraction; Neural Inhibition; | 1977 |
Subsensitivity of the presynaptic alpha adrenoceptors after short-term surgical denervation of the cat nictitating membrane.
Topics: Animals; Cats; Clonidine; Denervation; Electric Stimulation; Female; In Vitro Techniques; Male; Musc | 1977 |
The effect of different calcium concentrations on the inhibitory effect of presynaptic alpha-adrenoceptors in the rat vas deferens.
Topics: Animals; Calcium; Clonidine; Electric Stimulation; Guanethidine; In Vitro Techniques; Male; Muscle C | 1978 |
Binding to alpha-adrenergic receptors: differential pharmacological potencies and binding affinities of benzodioxanes.
Topics: Animals; Cerebral Cortex; Clonidine; Hydroxydopamines; Male; Muscle Contraction; Norepinephrine; Pip | 1979 |
Pre- and postsynaptic components in effect of drugs with alpha adrenoceptor affinity.
Topics: Action Potentials; Adrenergic alpha-Agonists; Animals; Clonidine; Cocaine; Corticosterone; In Vitro | 1975 |
Pharmacology of BS 100-141, a centrally acting antihypertensive drug.
Topics: Adrenergic alpha-Agonists; Animals; Antihypertensive Agents; Arteries; Blood Pressure; Brain Chemist | 1975 |
Effect of clonidine on the contractile responsiveness of aortic smooth muscle to norepinephrine.
Topics: Animals; Aorta; Clonidine; Male; Muscle Contraction; Muscle, Smooth; Norepinephrine; Potassium Chlor | 1979 |
A pre-synaptic inhibitory effect of 5-hydroxytryptamine on the electrically induced twitch response of the rat vas deferens.
Topics: Animals; Clonidine; Electric Stimulation; In Vitro Techniques; Male; Methysergide; Muscle Contractio | 1979 |
Studies on the inhibitory action of somatostatin in the electrically stimulated rat vas deferens.
Topics: Animals; Calcium; Clonidine; Electric Stimulation; Endorphins; In Vitro Techniques; Male; Muscle Con | 1979 |
Effect of prostaglandin E1 and indomethacin on responses of longitudinal muscle of guinea-pig ileum to cholecystokinin.
Topics: Acetylcholine; Animals; Cecum; Cholecystokinin; Clonidine; Electric Stimulation; Female; Guinea Pigs | 1979 |
Prejunctional clonidine-adenosine interactions in the rat vas deferens [proceedings].
Topics: Adenosine; Animals; Clonidine; Drug Interactions; In Vitro Techniques; Male; Muscle Contraction; Mus | 1979 |
The inhibitory effects of clonidine on the contractions of the guinea-pig ileum in the morphine-dependent and withdrawn states [proceedings].
Topics: Animals; Clonidine; Depression, Chemical; Guinea Pigs; Humans; Ileum; In Vitro Techniques; Morphine | 1978 |
Differentiation between pre- and postjunctional alpha-receptors in guinea pig ileum and rabbit aorta.
Topics: Animals; Aorta, Thoracic; Cimetidine; Clonidine; Dibenzylchlorethamine; Dose-Response Relationship, | 1978 |
The effect of haloperidol, spiperone and pimozide on the flexor reflex of the hind limb of the spinal rat.
Topics: Animals; Butyrophenones; Clonidine; Denervation; Fenfluramine; Haloperidol; Hindlimb; Lysergic Acid | 1978 |
Peripheral vascular effects of clonidine independent of a reduction in sympathetic activity [proceedings].
Topics: Animals; Cats; Clonidine; Muscle Contraction; Muscle, Smooth; Vasoconstrictor Agents | 1976 |
Desensitization of the rat aortic strip to vasopressin by infusions of noradrenaline [proceedings].
Topics: Animals; Aorta; Clonidine; In Vitro Techniques; Muscle Contraction; Norepinephrine; Propranolol; Rat | 1976 |
The effects of serotonergic and antiserotonergic drugs on the flexor reflex of spinal rat: a proposed model to evaluate the action on the central serotonin receptor.
Topics: 5-Hydroxytryptophan; Amphetamine; Animals; Anthracenes; Clonidine; Cyproheptadine; Decerebrate State | 1976 |
Inhibitory effects of clonidine and BS 100-141 on responses to sympathetic nerve stimulation in cats and rabbits.
Topics: Animals; Autonomic Fibers, Postganglionic; Autonomic Fibers, Preganglionic; Cats; Clonidine; Electri | 1975 |
Pharmacological actions of the antihypertensive agent N-amidino-2-(2,6-dichlorophenyl)acetamide hydrochloride (BS 100-141).
Topics: Animals; Antihypertensive Agents; Arteries; Autonomic Fibers, Preganglionic; Behavior, Animal; Blood | 1975 |
Pharmacological properties of 2-(2-chloro-p-toluidino)-2-imidazoline-nitrate (tolonidine), a new antihypertensive agent. II. Action on cardiac contraction, circulatory parameters, autonomic receptors and diuresis.
Topics: Animals; Antihypertensive Agents; Aorta; Autonomic Nervous System; Blood Pressure; Cerebrovascular C | 1975 |
Role of K+ channels in the modulation of cholinergic neural responses in guinea-pig and human airways.
Topics: Adolescent; Adult; Animals; Benzopyrans; Charybdotoxin; Cholinergic Fibers; Clonidine; Cromakalim; E | 1992 |
Action of alpha 2A-adrenergic receptors in circular smooth muscle of canine proximal colon.
Topics: Adenylate Cyclase Toxin; Animals; Binding, Competitive; Cell Membrane; Clonidine; Colforsin; Colon; | 1992 |
Separation of putative alpha 1A- and alpha 1B-adrenoceptor mediated components in the tension response of the rat vas deferens to electrical field stimulation.
Topics: Animals; Clonidine; Electric Stimulation; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smo | 1992 |
Effects of chronic ethanol consumption on alpha-adrenergic-induced contractions in rat thoracic aorta.
Topics: Animals; Aorta, Thoracic; Clonidine; Ethanol; In Vitro Techniques; Muscle Contraction; Muscle, Smoot | 1992 |
Effects of estrogen pretreatment of the spare alpha 1-adrenoceptors and the slow and fast components of the contractile response of the isolated female rat aorta.
Topics: Animals; Aorta, Thoracic; Clonidine; Estrogens; Female; Muscle Contraction; Muscle, Smooth, Vascular | 1992 |
The contribution of alpha-adrenoceptors to neurally-mediated contractions of the rabbit urethral smooth muscle.
Topics: Animals; Clonidine; Electric Stimulation; Female; In Vitro Techniques; Isometric Contraction; Muscle | 1992 |
Alpha 1B-adrenoceptor mechanisms in rabbit iris dilator.
Topics: Animals; Clonidine; Dose-Response Relationship, Drug; In Vitro Techniques; Iris; Male; Methoxamine; | 1992 |
Actions of noradrenaline on myenteric neurons in the guinea pig gastric antrum.
Topics: Acetylcholine; Animals; Clonidine; Gastrointestinal Motility; Guinea Pigs; In Vitro Techniques; Male | 1992 |
Pharmacological characterization of alpha 2-adrenoceptors in isolated jejunum of rabbits.
Topics: Animals; Clonidine; Colforsin; GTP-Binding Proteins; Guanabenz; In Vitro Techniques; Jejunum; Muscle | 1992 |
[Alpha adrenoceptor subtypes in smooth muscles of rat pulmonary artery].
Topics: Animals; Clonidine; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth, Vascular; Nifedip | 1992 |
Effects of tizanidine on morphine physical dependence: attenuation and intensification.
Topics: Adrenergic alpha-Agonists; Analgesics; Animals; Aspartic Acid; Behavior, Animal; Clonidine; Glutamat | 1992 |
Vascular alpha-adrenoceptor affinity variation is not due to varying populations of subtypes distinguished by WB 4101 and chlorethylclonidine.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Arteries; Clonidine; Dioxanes; Fem | 1992 |
Effect of aspirin on the contractility of aortic smooth muscle in female spontaneously hypertensive rats.
Topics: Adrenergic alpha-Agonists; Animals; Aorta; Aspirin; Blood Pressure; Clonidine; Female; Hypertension; | 1992 |
Is the neuronal ATP release from guinea-pig vas deferens subject to alpha 2-adrenoceptor-mediated modulation?
Topics: Adenosine Triphosphate; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Berberine; | 1992 |
The adrenoceptor agonist, SDZ NVI 085, discriminates between alpha 1A- and alpha 1B-adrenoceptor subtypes in vas deferens, kidney and aorta of the rat.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Aorta, Thoracic; Bridged Bicyclo C | 1992 |
Calcium entry blockade as a mechanism for chlordimeform-induced inhibition of motor activity in the isolated guinea-pig ileum.
Topics: Adrenergic alpha-Antagonists; Animals; Chlorphenamidine; Clonidine; Dioxanes; Drug Interactions; Ele | 1992 |
Pharmacological characterization of contractile responses induced by alpha 1-agonists, norepinephrine and clonidine, by selective antagonists of their subtypes in rabbit thoracic aorta.
Topics: Adrenergic alpha-Agonists; Adrenergic beta-Antagonists; Animals; Aorta, Thoracic; Binding, Competiti | 1992 |
Effect of temperature reduction on the reactivity of the mouse vas deferens to adrenergic drugs.
Topics: Animals; Calcium; Clonidine; Cold Temperature; Dose-Response Relationship, Drug; Extracellular Space | 1992 |
Atypical presynaptic alpha-adrenoceptor modulation of neurally-mediated cholinergic responses in guinea-pig tracheal smooth muscle.
Topics: Animals; Clonidine; Drug Interactions; Guinea Pigs; Male; Muscle Contraction; Muscle, Smooth; Norepi | 1992 |
MDL 27,531 reduces spontaneous hindlimb contractions in rats with chronic transections of the spinal cord.
Topics: Animals; Anticonvulsants; Clonidine; Decerebrate State; Hindlimb; Male; Muscle Contraction; Muscle T | 1992 |
Evidence for a bioactive clonidine-displacing substance in peripheral tissues and serum.
Topics: Adrenal Glands; Adrenalectomy; Animals; Brain Chemistry; Clonidine; Gastric Fundus; Male; Muscle Con | 1992 |
Interactions between the effects of endothelin-1, clonidine and yohimbine on electrically-induced contractions in rat vas deferens.
Topics: Adenosine Triphosphate; Animals; Clonidine; Electric Stimulation; Endothelins; In Vitro Techniques; | 1992 |
Influence of extracellular Ca2+ on the modulation of alpha-adrenergic-induced contractions in rat aorta.
Topics: Animals; Aorta, Thoracic; Calcium; Clonidine; Endothelium, Vascular; In Vitro Techniques; Muscle Con | 1991 |
Release of contractile agents from rat vas deferens by clonidine.
Topics: Animals; Clonidine; Female; Guinea Pigs; Ileum; In Vitro Techniques; Male; Muscle Contraction; Muscl | 1991 |
[Measurement of isometric tracheal tension induced by injection into tracheal arterial circulation in vivo].
Topics: Acetylcholine; Animals; Arteries; Clonidine; Dogs; Dose-Response Relationship, Drug; Histamine; Inje | 1991 |
Effects of aging on alpha 2-adrenoceptor mechanisms in isolated guinea-pig tracheal preparations.
Topics: Adrenergic alpha-Agonists; Aging; Animals; Clonidine; Corticosterone; Dinoprost; Guinea Pigs; In Vit | 1991 |
Relation between adrenergic neurogenic contraction and alpha 1-adrenoceptor subtypes in dog mesenteric and carotid arteries and rabbit carotid arteries.
Topics: Acetonitriles; Adrenergic alpha-Antagonists; Animals; Carotid Arteries; Clonidine; Dogs; Electric St | 1991 |
Pharmacological characterization of alpha adrenergic receptors in the young and old female rabbit urethra.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Aging; Animals; Calcium; Clonidine; Female; | 1991 |
Modulation of alpha-adrenergic-induced contractions by endothelium-derived relaxing factor in rat aorta.
Topics: Adrenergic alpha-Agonists; Animals; Aorta, Thoracic; Clonidine; Endothelium, Vascular; In Vitro Tech | 1991 |
Pharmacological profile of the novel alpha-adrenoceptor antagonist KT-611 (naftopidil).
Topics: Adrenergic alpha-Antagonists; Animals; Aorta, Thoracic; Binding, Competitive; Clonidine; Dogs; Elect | 1991 |
Adrenoceptors of the human internal thoracic artery.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Agonists; Clonidine; Dinoprostone; Humans; In Vitro Te | 1991 |
Influence of fenoldopam and quinpirole in the guinea-pig stomach.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Clonidine; Dopamine; Dopamine A | 1991 |
Human plasma-derived material with clonidine displacing substance (CDS)-like properties contracts the isolated rat aorta.
Topics: Adrenergic alpha-Antagonists; Animals; Aorta; Blood; Brain; Clonidine; Dioxanes; Female; In Vitro Te | 1991 |
Contractile and relaxant effects of alpha-adrenergic agonists on rat aorta.
Topics: Adrenergic alpha-Agonists; Animals; Aorta, Thoracic; Clonidine; Endothelium, Vascular; In Vitro Tech | 1991 |
Alpha-adrenoceptor blocking properties of vesamicol.
Topics: Adrenergic alpha-Antagonists; Animals; Clonidine; Corticosterone; Desipramine; Dioxanes; Electric St | 1991 |
Alpha 1A-adrenoceptors in rabbit bronchus.
Topics: Adrenergic alpha-Antagonists; Animals; Bronchi; Clonidine; Dioxanes; In Vitro Techniques; Male; Musc | 1991 |
Subtypes of alpha 1-adrenoceptors involved in noradrenaline-induced contractions of rat thoracic aorta and dog carotid artery.
Topics: Adrenergic alpha-Antagonists; Animals; Aorta, Thoracic; Carotid Arteries; Clonidine; Dogs; Electroph | 1991 |
Some pharmacological characteristics of the guinea pig ileum opioid system activated by cholecystokinin.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1990 |
Reproducible withdrawal contractions of isolated guinea-pig ileum after brief morphine exposure: effects of clonidine and nifedipine.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1990 |
Enhanced contractile responses of arteries from diabetic rats to alpha 1-adrenoceptor stimulation in the absence and presence of extracellular calcium.
Topics: Adrenergic alpha-Agonists; Animals; Aorta, Thoracic; Arteries; Calcium; Clonidine; Diabetes Mellitus | 1990 |
Endotoxin-induced impairment of vascular smooth muscle contractions elicited by different mechanisms.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1990 |
Potentiating effect of daunorubicin on vasocontractile responses to KCl and BAY K 8644 in rat aorta.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1990 |
Omega conotoxin and prejunctional modulation of the biphasic response of the rat isolated urinary bladder to single pulse electrical field stimulation.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1991 |
Participation of endothelium-derived relaxing factor and role of cyclic GMP in inhibitory effects of endothelium on contractile responses elicited by alpha-adrenoceptor agonists in rat aorta.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Adrenergic alpha-Agonists; Animals; Aorta, Thoracic; Arginin | 1991 |
Comparative evaluation of lisuride and terguride, ergot alkaloid derivatives, on the field-stimulated vas deferens of mouse.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Binding, Competitive; Clonidine | 1991 |
Subtypes of alpha 1-adrenoceptors in rat blood vessels.
Topics: Animals; Aorta, Thoracic; Blood Vessels; Clonidine; Dioxanes; In Vitro Techniques; Male; Mesenteric | 1990 |
Concomitant depression of locus coeruleus neurons and of flexor reflexes by an alpha 2-adrenergic agonist in rats: a possible mechanism for an alpha 2-mediated muscle relaxation.
Topics: Adrenergic alpha-Agonists; Animals; Clonidine; Female; Locus Coeruleus; Male; Muscle Contraction; Mu | 1990 |
Naloxone potentiates contractile responses to epinephrine in isolated canine arteries.
Topics: Animals; Clonidine; Corticosterone; Dogs; Dose-Response Relationship, Drug; Drug Synergism; Dynorphi | 1990 |
Alpha 2-adrenoceptor mechanisms in guinea-pig trachea.
Topics: Adrenergic alpha-Antagonists; Animals; Clonidine; Guinea Pigs; In Vitro Techniques; Iodine Radioisot | 1990 |
Two pharmacologically distinct alpha 1-adrenoceptor subtypes in the contraction of rabbit aorta: each subtype couples with a different Ca2+ signalling mechanism and plays a different physiological role.
Topics: Adrenergic alpha-Antagonists; Animals; Aorta; Binding Sites; Calcium; Clonidine; Dioxanes; In Vitro | 1990 |
Bethanechol induced contraction in mouse spleen.
Topics: Animals; Bethanechol; Bethanechol Compounds; Clonidine; In Vitro Techniques; Mice; Muscle Contractio | 1990 |
Different desensitization mechanisms of two alpha 1-adrenoceptor subtypes in the contraction of rabbit aorta.
Topics: Adrenergic alpha-Antagonists; Animals; Aorta; Clonidine; Dioxanes; In Vitro Techniques; Muscle Contr | 1990 |
A novel in vivo test for drugs affecting central serotonergic and adrenergic systems.
Topics: 5-Hydroxytryptophan; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Albuterol; Animals; Cl | 1990 |
Structure-activity relationships in 1,4-benzodioxan-related compounds. 2. Role of the amine function on alpha-adrenoreceptor blocking activity.
Topics: Adrenergic alpha-Antagonists; Animals; Clonidine; Cocaine; Dioxanes; Electric Stimulation; In Vitro | 1990 |
Attenuating effects of intrathecal clonidine on the exercise pressor reflex.
Topics: Action Potentials; Afferent Pathways; Animals; Cats; Clonidine; Electric Stimulation; Hemodynamics; | 1991 |
Study of the contraction induced by norepinephrine and clonidine in the isolated guinea-pig ileum.
Topics: Animals; Atropine; Clonidine; Guinea Pigs; Ileum; In Vitro Techniques; Indomethacin; Male; Muscle Co | 1991 |
Clonidine inhibits vesico-sphincter reflexes in patients with chronic spinal lesions.
Topics: Adult; Blood Pressure; Clonidine; Electromyography; Female; Humans; Muscle Contraction; Muscle Spast | 1991 |
Effect of clonidine, nimodipine and diltiazem on the in vitro opioid withdrawal response in the guinea-pig ileum.
Topics: Animals; Clonidine; Diltiazem; Electric Stimulation; Guinea Pigs; Ileum; In Vitro Techniques; Morphi | 1990 |
Characterization of responses to cromakalim and pinacidil in smooth and cardiac muscle by use of selective antagonists.
Topics: Animals; Aorta, Thoracic; Benzopyrans; Clonidine; Coronary Vessels; Cromakalim; Dogs; Electric Stimu | 1990 |
Involvement of alpha 2-adrenergic receptors in the vagal reflex-induced tracheal constriction.
Topics: Acetylcholine; Animals; Blood Pressure; Clonidine; Dogs; Dose-Response Relationship, Drug; Electric | 1990 |
Role of alpha adrenoceptors in opossum internal anal sphincter.
Topics: Anal Canal; Animals; Clonidine; Muscle Contraction; Naphazoline; Opossums; Phenylephrine; Prazosin; | 1990 |
The properties of the clonidine withdrawal response of guinea-pig isolated ileum.
Topics: Animals; Atropine; Clonidine; Drug Interactions; Enkephalin, Methionine; Guinea Pigs; Humans; Ileum; | 1985 |
Alpha-adrenoceptors and muscarinic receptors in the isolated human prostate.
Topics: Acetylcholine; Aged; Carbachol; Clonidine; Electric Stimulation; Humans; Male; Middle Aged; Muscle C | 1985 |
(Imidazolinyl-2)-2-benzodioxane 1-4 (idazoxan) and its stereoisomers, new alpha 2-antagonists.
Topics: Animals; Azepines; Chickens; Clonidine; Dioxanes; Dioxins; Heart Rate; Idazoxan; Imidazoles; Male; M | 1985 |
Comparison of the effects of clonidine and guanfacine on the histamine liberation from human mast cells and basophils and on the human bronchial smooth muscle activity.
Topics: Adrenergic alpha-Agonists; Basophils; Bronchi; Carbachol; Cimetidine; Clonidine; Electric Stimulatio | 1987 |
Hyperactivity of Ca channels in vasa deferentia smooth muscle of diabetic rats.
Topics: Animals; Clonidine; Diabetes Mellitus, Experimental; Ion Channels; Male; Muscle Contraction; Muscle, | 1987 |
Effect of endothelin-1 on calcium channel gating by agonists in vascular smooth muscle.
Topics: Animals; Aorta, Thoracic; Calcium Channel Agonists; Calcium Channels; Calcium Radioisotopes; Clonidi | 1989 |
Amphetamine antagonizes the presynaptic inhibitory effect of clonidine through an interaction at the level of the alpha 2-adrenoceptors.
Topics: Amphetamine; Animals; Binding, Competitive; Clonidine; Electric Stimulation; In Vitro Techniques; Is | 1989 |
Analysis of the presence of postjunctional alpha-2 adrenoceptors in the rat anococcygeus muscle.
Topics: Animals; Clonidine; Dioxanes; Electric Stimulation; Idazoxan; In Vitro Techniques; Male; Muscle Cont | 1989 |
Effect of l-ephedrine on cholinergic neurotransmission in the isolated guinea pig ileum.
Topics: Animals; Clonidine; Ephedrine; Female; Guinea Pigs; Hydroxydopamines; Ileum; In Vitro Techniques; Ma | 1989 |
An examination of the putative sigma-receptor in the mouse isolated vas deferens.
Topics: Animals; Clonidine; Electric Stimulation; In Vitro Techniques; Male; Mice; Mice, Inbred DBA; Muscle | 1989 |
Structure-activity relationships in prazosin-related compounds. Effect of replacing a piperazine ring with an alkanediamine moiety on alpha 1-adrenoreceptor blocking activity.
Topics: Adrenergic alpha-Antagonists; Animals; Chemical Phenomena; Chemistry; Clonidine; In Vitro Techniques | 1989 |
Comparative effects of the alpha-adrenoceptor agonists noradrenaline, phenylephrine and clonidine in the human saphenous vein in vivo and in vitro.
Topics: Adrenergic alpha-Agonists; Adult; Aged; Clonidine; Female; Humans; Male; Middle Aged; Muscle Contrac | 1989 |
The inhibition of alpha 1-adrenoceptor-mediated contractions of rabbit pulmonary artery by Ca2+-withdrawal, pertussis toxin and N-ethylmaleimide is dependent on agonist intrinsic efficacy.
Topics: Adrenergic alpha-Agonists; Animals; Azepines; Calcium; Calcium Channel Blockers; Clonidine; Ethylmal | 1989 |
Characterization of autonomic receptors in neonatal urinary tract smooth muscle.
Topics: Adrenergic Agonists; Animals; Animals, Newborn; Carbachol; Clonidine; Dihydroalprenolol; Dose-Respon | 1989 |
Comparative effects of verapamil and D-600 on the contractile responses produced by neurotransmitters and depolarizing agents in the rat isolated seminal vesicle.
Topics: Acetylcholine; Animals; Carbachol; Clonidine; Gallopamil; In Vitro Techniques; Male; Muscle Contract | 1989 |
Greater tension is developed at the same level of cytosolic Ca2+ concentration in the presence of clonidine, an adrenergic partial agonist, than in the presence of norepinephrine.
Topics: Animals; Calcium; Clonidine; Cytosol; Dose-Response Relationship, Drug; Male; Muscle Contraction; Mu | 1989 |
[Influence of age and sex on the reaction of isolated rat bladder to autonomic agents].
Topics: Acetylcholine; Age Factors; Animals; Autonomic Agents; Clonidine; Female; In Vitro Techniques; Isopr | 1989 |
New isoxazole derivatives provided with antihypertensive activity.
Topics: Animals; Antihypertensive Agents; Aorta, Thoracic; Binding, Competitive; Chemical Phenomena; Chemist | 1989 |
Evidence for the existence of prejunctional receptor sites for dopamine in the mouse vas deferens.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Adrenergic Fibers; Animals; Clonidine; E | 1989 |
The effect of hyperthyroidism and hypothyroidism on alpha 1- and alpha 2-adrenergic responsiveness in rat aortic smooth muscle.
Topics: Animals; Aorta; Clonidine; Hyperthyroidism; Hypothyroidism; In Vitro Techniques; Male; Muscle Contra | 1987 |
Possible catecholaminergic-opioidergic control of blood pressure during muscular contraction.
Topics: Animals; Blood Pressure; Cats; Clonidine; Dose-Response Relationship, Drug; Isometric Contraction; M | 1987 |
Synthesis and structure-activity relationships of 2-sulfonamido-1,3,4,6,7,11b alpha-hexahydro-2H-benzo[a]quinolizines as alpha 2-adrenoceptor antagonists.
Topics: Animals; Chemical Phenomena; Chemistry; Clonidine; Dioxanes; Idazoxan; Male; Methoxamine; Molecular | 1988 |
Influence of the endothelium on contractile responses of arteries from diabetic rats.
Topics: Acetylcholine; Animals; Aorta, Thoracic; Arteries; Clonidine; Cyclic GMP; Diabetes Mellitus, Experim | 1988 |
Contractant and relaxant properties of the female rabbit urethral submucosa.
Topics: Adrenergic alpha-Antagonists; Animals; Clonidine; Electric Stimulation; Female; In Vitro Techniques; | 1985 |
Studies of alpha 2-adrenoceptor antagonist potency in vitro: comparisons in tissues from rats, rabbits, dogs and humans.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Azepines; Clonidine; Dioxanes; Dog | 1985 |
Electrical membrane events in response to alpha-adrenoceptor stimulation.
Topics: Adrenergic alpha-Agonists; Animals; Azepines; Calcium; Cell Membrane; Clonidine; Female; Male; Membr | 1985 |
alpha-Adrenoceptor agonists and the Ca2+-dependence of smooth muscle contraction: evidence for subtypes of receptors or for agonist-dependent differences in the agonist-receptor interaction?
Topics: Adrenergic alpha-Agonists; Animals; Calcium; Clonidine; Ethanolamines; Male; Methoxamine; Muscle Con | 1985 |
Pharmacological analysis of alpha-2 adrenergic mechanisms in nociception and ataxia.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Ataxia; Binding, Competitive; Brai | 1985 |
An electrophysiological study of alpha-adrenoceptor mediated excitation-contraction coupling in the smooth muscle cells of the rat saphenous vein.
Topics: Adrenergic alpha-Agonists; Animals; Azepines; Clonidine; Electrophysiology; In Vitro Techniques; Mal | 1985 |
Antagonism by clonidine of the adenosine-induced inhibition of the twitch contraction of the guinea-pig Oddi sphincter.
Topics: Adenosine; Alprostadil; Ampulla of Vater; Animals; Clonidine; Dipyridamole; Electric Stimulation; Gu | 1985 |
Studies on YM-12617: a selective and potent antagonist of postsynaptic alpha 1-adrenoceptors.
Topics: Adrenergic alpha-Antagonists; Animals; Aorta; Blood Pressure; Brain; Brimonidine Tartrate; Clonidine | 1985 |
A difference in the affinity of some selective alpha 2-adrenoceptor antagonists when compared on isolated vasa deferentia of rat and rabbit.
Topics: Adrenergic alpha-Antagonists; Animals; Brimonidine Tartrate; Clonidine; Electric Stimulation; In Vit | 1985 |
Pharmacological characterization of alpha-adrenergic receptor subtypes mediating contraction in human mesenteric arteries and veins.
Topics: Adrenergic alpha-Agonists; Adult; Aged; Clonidine; Drug Interactions; Female; Humans; Male; Mesenter | 1985 |
Differential blocking actions of idazoxan against the inhibitory effects of 6-fluoronoradrenaline and clonidine in the rat vas deferens.
Topics: Adrenergic alpha-Antagonists; Animals; Clonidine; Cocaine; Dioxanes; Dioxins; Electric Stimulation; | 1985 |
Physiological antagonism caused by adrenergic stimulation of canine tracheal muscle.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Animals; Clonidine; Dogs; Female; Male; M | 1986 |
Interaction between clonidine and histamine on the guinea-pig isolated trachea.
Topics: Animals; Clonidine; Drug Synergism; Guinea Pigs; Histamine; In Vitro Techniques; Male; Muscle Contra | 1985 |
Alpha-adrenolytic properties of apogalanthamine and azapetine analogs.
Topics: Adrenergic alpha-Antagonists; Animals; Azocines; Clonidine; Dibenzazepines; Dose-Response Relationsh | 1985 |
Adrenoceptor blocking properties of the stereoisomers of amosulalol (YM-09538) and the corresponding desoxy derivative (YM-11133).
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Animals; Antihypertensive Agents; Brain; | 1986 |
Regional distribution of alpha-adrenoceptor subtypes in the female rabbit urethra.
Topics: Adrenergic alpha-Agonists; Animals; Clonidine; Female; Muscle Contraction; Muscle, Smooth; Norepinep | 1986 |
Effect of diltiazem upon contractile responses to phenylephrine, cirazoline, Sgd 101/75, St 587 and B-HT 920 in rabbit aorta and dog saphenous vein preparations.
Topics: Adrenergic alpha-Agonists; Animals; Aorta, Thoracic; Azepines; Benzazepines; Clonidine; Diltiazem; D | 1986 |
Role of efficacy in the assessment of the actions of alpha-adrenoceptor agonists in rat aorta with endothelium.
Topics: Adrenergic alpha-Agonists; Animals; Aorta, Thoracic; Clonidine; Endothelium; Female; In Vitro Techni | 1986 |
Presynaptic alpha-adrenoceptor mediated inhibition of the neurogenic cholinergic contraction in the isolated intestinal bulb of the carp (Cyprinus carpio).
Topics: Animals; Atropine; Carps; Catecholamines; Clonidine; Cyprinidae; Electric Stimulation; Epinephrine; | 1986 |
Alpha 1- and alpha 2-adrenoceptor agonist-induced contraction in rat mesenteric artery upon removal of endothelium.
Topics: Adrenergic alpha-Agonists; Animals; Clonidine; Endothelium; Histamine; In Vitro Techniques; Male; Me | 1986 |
Ca++ utilization in the constriction of rat aorta to full and partial alpha-1 adrenoceptor agonists.
Topics: Adrenergic alpha-Agonists; Animals; Aorta; Calcium; Clonidine; Dose-Response Relationship, Drug; Eth | 1986 |
The St 587-induced flexor reflex in pithed rats: a model to evaluate central alpha 1-receptor blocking properties.
Topics: Adrenergic alpha-Antagonists; Animals; Antipsychotic Agents; Binding, Competitive; Clonidine; Decere | 1986 |
DJ-7141, a new alpha-2 agonist with only a mild hypotensive action.
Topics: Adrenergic alpha-Agonists; Animals; Antihypertensive Agents; Blood Pressure; Clonidine; Dogs; Female | 1986 |
Evidence for a receptor mediated action of norepinephrine distinct from alpha- and beta-adrenoceptors.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Brimonidine Tartrate; Clonidine; C | 1986 |
Gastric antisecretory and antiulcer effects of WHR1582A, a compound exerting alpha-2 adrenoceptor agonist activity.
Topics: Adrenergic alpha-Agonists; Animals; Anti-Ulcer Agents; Aspirin; Carbachol; Clonidine; Cysteamine; Di | 1987 |
Potentiation of the responses to transmural nerve stimulation by alpha-agonists: a possible role in vivo.
Topics: Adrenergic alpha-Agonists; Animals; Clonidine; Dogs; Electric Stimulation; Epinephrine; Indomethacin | 1987 |
Depression of reticulo-ruminal motor functions through the stimulation of alpha 2-adrenoceptors.
Topics: Adrenergic alpha-Agonists; Animals; Cattle; Clonidine; Female; Imidazoles; Muscle Contraction; Retic | 1987 |
Evidence that cGMP is the mediator of endothelium-dependent inhibition of contractile responses of rat arteries to alpha-adrenoceptor stimulation.
Topics: Acetylcholine; Adrenergic alpha-Agonists; Aminoquinolines; Animals; Aorta; Clonidine; Cyclic GMP; En | 1987 |
Two kinds of modification by 5-methoxy-N,N-dimethyltryptamine of contractile responses to electrical stimulation of isolated guinea-pig vas deferens.
Topics: Adenosine Triphosphate; Adrenergic alpha-Antagonists; Animals; Clonidine; Cyproheptadine; Electric S | 1987 |
Analysis of putative alpha-1s adrenoceptor agonism by Sgd 101/75 in the rat anococcygeus muscle.
Topics: Adrenergic alpha-Agonists; Animals; Clonidine; Dose-Response Relationship, Drug; In Vitro Techniques | 1987 |
The adrenergic agonist tizanidine has differential effects on flexor reflexes of intact and spinalized rat.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Clonidine; Decerebrate State; Dose-Response | 1987 |
The mode of vasoinhibitory action of a pyridazione derivative (MCI-154), a new cardiotonic agent, on contractile responses induced by alpha-adrenoceptor agonists and 45Ca influx in isolated vascular smooth muscles.
Topics: Adrenergic alpha-Agonists; Animals; Aorta, Thoracic; Azepines; Calcium; Calcium Radioisotopes; Cardi | 1988 |
A peripherally acting alpha-2 adrenoceptor antagonist: L-659,066.
Topics: Adrenergic alpha-Antagonists; Animals; Binding, Competitive; Blood-Brain Barrier; Callitrichinae; Cl | 1988 |
Prejunctional alpha 2-adrenergic properties of S-3341 (dicyclopropylmethyl)amino-2-delta-2-oxazoline: a comparison with clonidine.
Topics: Adrenergic alpha-Agonists; Animals; Clonidine; Electric Stimulation; In Vitro Techniques; Male; Musc | 1987 |
Responsiveness of isolated monkey coronary arteries contracted with alpha 1- and alpha 2-adrenoceptor agonists to diltiazem.
Topics: Adrenergic alpha-Agonists; Animals; Clonidine; Coronary Vessels; Diltiazem; Dinoprost; Female; In Vi | 1988 |
Precontraction-induced contractile response of isolated canine portal vein to alpha-2 adrenoceptor agonists.
Topics: Adrenergic alpha-Agonists; Animals; Azepines; Calcimycin; Cats; Clonidine; Female; In Vitro Techniqu | 1988 |
Alpha-adrenoceptor occupancy by N,N-dimethyl-2-bromo-2-phenethylamine hydrobromide (DMPEA) in rat vas deferens.
Topics: Adrenergic alpha-Antagonists; Animals; Clonidine; Dioxanes; Idazoxan; In Vitro Techniques; Male; Mus | 1988 |
Enhanced vascular alpha-adrenergic neuroeffector system in diabetes: importance of calcium.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Calcium; Clonidine; Diabetes Melli | 1988 |
Structure-activity relationships in 1,4-benzodioxan-related compounds. Investigation on the role of the dehydrodioxane ring on alpha 1-adrenoreceptor blocking activity.
Topics: Adrenergic alpha-Antagonists; Animals; Binding Sites; Chemical Phenomena; Chemistry; Clonidine; Diox | 1988 |
Effects of cooling on alpha-1-adrenoceptor mechanisms in rat aorta.
Topics: Animals; Aorta, Thoracic; Binding, Competitive; Clonidine; Cold Temperature; In Vitro Techniques; Ma | 1988 |
Investigations into the mechanism of the antihypertensive effect of SGB-1534, a novel alpha 1-adrenoceptor antagonist, in rats.
Topics: Adrenergic alpha-Antagonists; Animals; Antihypertensive Agents; Aorta, Thoracic; Blood Pressure; Clo | 1988 |
Myorelaxant effect after intrathecal injection of antispastic drugs in rats.
Topics: Animals; Baclofen; Clonidine; Dose-Response Relationship, Drug; Female; H-Reflex; Injections, Spinal | 1989 |
Prejunctional alpha 2-adrenoceptor mediated inhibitory action of clonidine and B-HT 920, but not urapidil in guinea pig ileum.
Topics: Animals; Azepines; Clonidine; Electric Stimulation; Female; Guinea Pigs; Ileum; In Vitro Techniques; | 1985 |
Evaluation of the alpha 1- and alpha 2-adrenoceptor effects of detomidine, a novel veterinary sedative analgesic.
Topics: Analgesics; Animals; Clonidine; Electric Stimulation; Female; Hypnotics and Sedatives; Imidazoles; I | 1985 |
Selectivity of (+)-4-propyl-9-hydroxynaphthoxazine [(+)-PHNO] for dopamine receptors in vitro and in vivo.
Topics: Animals; Apomorphine; Cats; Clonidine; Ergolines; In Vitro Techniques; Lisuride; Male; Muscle Contra | 1985 |
Cirazoline, an alpha 2-adrenoceptor antagonist in guinea-pig ileum.
Topics: Acetylcholine; Animals; Clonidine; Dose-Response Relationship, Drug; Electric Stimulation; Female; G | 1985 |
Neuropeptide Y is a potent inhibitor of cyclic AMP accumulation in feline cerebral blood vessels.
Topics: Animals; Cats; Cerebral Arteries; Clonidine; Colforsin; Cyclic AMP; In Vitro Techniques; Muscle Cont | 1985 |
The effects of sodium nitroprusside and 8-bromo-cyclic GMP on electrical and mechanical activities of the rat tail artery.
Topics: Animals; Arteries; Clonidine; Cyclic GMP; Electrophysiology; Ferricyanides; In Vitro Techniques; Mal | 1985 |
Dual effects of clonidine on micturition reflex in urethane anesthetized rats.
Topics: Anesthesia; Animals; Clonidine; Electric Stimulation; Hydroxydopamines; Injections, Intraventricular | 1985 |
[Alpha-adrenolytic activity of substance DH 1011].
Topics: Animals; Arteries; Carbolines; Clonidine; Dogs; Hindlimb; In Vitro Techniques; Muscle Contraction; P | 1985 |
An endogenous brain substance, CDS (clonidine-displacing-substance), inhibits the twitch response of rat vas deferens.
Topics: Animals; Binding, Competitive; Brain Chemistry; Chromatography, High Pressure Liquid; Clonidine; Ele | 1986 |
Clonidine-evoked selective P1-purinoceptor antagonism of contraction of guinea-pig urinary bladder.
Topics: Adenosine Triphosphate; Animals; Clonidine; Electric Stimulation; Guinea Pigs; In Vitro Techniques; | 1986 |
Alpha 2-adrenoceptor-mediated contractile response to catecholamines in smooth muscle strips isolated from rainbow trout stomach (Salmo gairdneri).
Topics: Animals; Atropine; Catecholamines; Clonidine; Electric Stimulation; Epinephrine; Female; In Vitro Te | 1986 |
Alpha adrenergic receptors mediate angiotensin-induced prostaglandin production in the rabbit isolated vas deferens.
Topics: Angiotensin II; Angiotensin III; Animals; Clonidine; Male; Muscle Contraction; Phenylephrine; Prazos | 1987 |
Beta-endorphin-sensitive opioid receptors in the rat tail artery.
Topics: Animals; Arteries; beta-Endorphin; Clonidine; Electric Stimulation; Endorphins; In Vitro Techniques; | 1987 |
[Theophylline-induced changes in the presynaptic effects of adenosine, baclofen, clofelin and morphine in the myenteric plexus of the guinea pig].
Topics: Adenosine; Animals; Baclofen; Clonidine; Drug Interactions; Guinea Pigs; In Vitro Techniques; Morphi | 1987 |
Comparison of the responses to drugs acting on adrenoreceptors and muscarinic receptors in human isolated corpus cavernosum and cavernous artery.
Topics: Acetylcholine; Aged; Carbachol; Clonidine; Electric Stimulation; Ethanolamines; Humans; In Vitro Tec | 1985 |
Serotonin-induced contraction of canine saphenous vein: mediation by 5-HT1 receptors.
Topics: Animals; Clonidine; Dogs; Drug Interactions; Emetics; In Vitro Techniques; Ketanserin; Mianserin; Mu | 1985 |
Dependence and cross-dependence in the guinea-pig myenteric plexus.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics | 1988 |
Pharmacological nature of newer imidazoli(di)nes on rat anococcygeus muscle.
Topics: Animals; Clonidine; Imidazoles; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Norep | 1988 |
Clonidine displacing substance is biologically active on smooth muscle.
Topics: Animals; Cattle; Clonidine; Dinoprostone; Dogs; In Vitro Techniques; Muscle Contraction; Muscle, Smo | 1987 |
Effects of carotid artery occlusion on the pressor response induced by sustained isometric contraction in the cat.
Topics: Animals; Arterial Occlusive Diseases; Blood Pressure; Carotid Artery Diseases; Cats; Clonidine; Isom | 1987 |
[Clinico-therapeutic evaluation of the hypertensive patient by the isometric exertion test].
Topics: Adult; Antihypertensive Agents; Atenolol; Blood Pressure; Chlorthalidone; Clonidine; Female; Humans; | 1986 |
Isolation of a factor (substance B) that antagonizes presynaptic modulation: pharmacological properties.
Topics: 2-Chloroadenosine; Acetylcholine; Adenosine; Animals; Brain Chemistry; Clonidine; Guinea Pigs; Hexam | 1986 |
Modulation of vascular tonus by the endothelium in experimental diabetes.
Topics: Acetylcholine; Animals; Clonidine; Diabetes Mellitus, Experimental; Endothelium; Muscle Contraction; | 1987 |
Role of endothelium in the contractions induced by norepinephrine and clonidine in rat aorta.
Topics: Angiotensin II; Animals; Aorta, Thoracic; Clonidine; Endothelium; In Vitro Techniques; Indomethacin; | 1985 |
Adrenergic and non-adrenergic contraction of isolated urethral muscle from rabbit and man.
Topics: Adrenergic Fibers; Animals; Clonidine; Electric Stimulation; Female; Humans; Hydroxydopamines; In Vi | 1985 |
Effect of clonidine and naloxone on the pressor response during contraction of cat hind-limb muscles.
Topics: Animals; Blood Pressure; Cats; Clonidine; Female; Hindlimb; Isometric Contraction; Male; Muscle Cont | 1985 |
Cardiovascular effects and interaction with adrenoceptors of urapidil.
Topics: Animals; Antihypertensive Agents; Binding, Competitive; Cats; Clonidine; Decerebrate State; Female; | 1985 |
Importance of frequency and pulse with in field stimulation of the mouse vas deferens: different behaviour of twitch-inhibiting drugs.
Topics: Animals; Calcium; Clonidine; D-Ala(2),MePhe(4),Met(0)-ol-enkephalin; Electric Stimulation; Enkephali | 1985 |
Inhibition by diltiazem of norepinephrine release from sympathetic nerves in the rabbit pulmonary artery.
Topics: Animals; Benzazepines; Clonidine; Depression, Chemical; Diltiazem; Drug Interactions; Electric Stimu | 1985 |
Effects of chronic drug treatment on the sensitivity of mouse vas deferens to drugs.
Topics: Animals; Carbachol; Clonidine; Electric Stimulation; In Vitro Techniques; Male; Mice; Morphine; Musc | 1985 |
Comparison of the effects of clonidine on pre- and postsynaptic adrenoceptors in the rabbit pulmonary artery. Alpha-sympathomimetic inhibition of Neurogenic vasoconstriction.
Topics: Adrenergic alpha-Agonists; Animals; Clonidine; Cocaine; Corticosterone; Dose-Response Relationship, | 1974 |
Clonidine-induced inhibition of sympathetic nerve activity: no indication for a central presynaptic or an indirect sympathomimetic mode of action.
Topics: Animals; Autonomic Fibers, Postganglionic; Autonomic Fibers, Preganglionic; Blood Pressure; Brain Ch | 1974 |
Actions of clonidine and 2-(2-methyl-6-ethyl-cyclohexylamino)-2-oxazoline on postganglionic autonomic nerves.
Topics: Acetylcholine; Animals; Antihypertensive Agents; Autonomic Fibers, Postganglionic; Clonidine; Cycloh | 1972 |
Adrenergic neuron blockade by clonidine: comparison with guanethidine and local anesthetics.
Topics: Amphetamine; Anesthetics, Local; Animals; Antihypertensive Agents; Anura; Autonomic Fibers, Postgang | 1972 |
The effect of clonidine on human isolated smooth muscle.
Topics: Acetylcholine; Adrenergic alpha-Antagonists; Antihypertensive Agents; Clonidine; Colon; Drug Antagon | 1972 |
Effects of clonidine on excitation-contraction in guinea-pig taenia coli.
Topics: Animals; Clonidine; Colon; Electric Stimulation; Guinea Pigs; In Vitro Techniques; Muscle Contractio | 1972 |
The action of clonidine on isolated arterial preparations.
Topics: Animals; Arteries; Clonidine; Cocaine; Constriction; Ear, External; Histamine; Muscle Contraction; M | 1972 |
[Effect of 2-(2,6-dichlorphenylamino)-2-imidazoline hydrochloride (Clonidine) on contraction of and acetylcholine-liberation in the isolated, coaxial-electrically stimulated guinea pig ileum].
Topics: Acetylcholine; Animals; Antihypertensive Agents; Clonidine; Electric Stimulation; Female; Guinea Pig | 1971 |