clonidine has been researched along with Morphine Dependence in 97 studies
Clonidine: An imidazoline sympatholytic agent that stimulates ALPHA-2 ADRENERGIC RECEPTORS and central IMIDAZOLINE RECEPTORS. It is commonly used in the management of HYPERTENSION.
clonidine (amino form) : A clonidine that is 4,5-dihydro-1H-imidazol-2-amine in which one of the amino hydrogens is replaced by a 2,6-dichlorophenyl group.
Morphine Dependence: Strong dependence, both physiological and emotional, upon morphine.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Both alpha(2)-adrenoceptors and the L-arginine/nitric oxide (NO) pathway have been implicated in the modulation of morphine dependence." | 7.71 | The effects of simultaneous administration of alpha(2) -adrenergic agents with L-NAME or L-arginine on the development and expression of morphine dependence in mice. ( Fayaz-Dastgerdi, M; Homayoun, H; Khavandgar, S; Zarrindast, MR, 2002) |
| "We examined the effect of morphine dependence on alpha 2-adrenoceptors in guinea-pig brain." | 7.69 | [Changes in alpha 2-adrenoceptor binding nature in guinea-pig brain following the development of morphine dependence]. ( Asano, T; Dohi, S; Niwa, M; Nozaki, M; Ohta, S; Takeda, T, 1997) |
| "The densities of brain alpha 2-adrenoceptors and mu-opioid receptors, quantitated by means of the binding of the agonists [3H]clonidine and [3H]dihydromorphine, respectively, were studied during the development of morphine dependence and spontaneous withdrawal in the rat." | 7.67 | Modulation of brain alpha 2-adrenoceptor and mu-opioid receptor densities during morphine dependence and spontaneous withdrawal in rats. ( García-Sevilla, JA; Ugedo, L; Ulibarri, I, 1987) |
| "Clonidine's action on naloxone (Nx)-induced suppression of fixed-ratio (FR15) responding and body weight loss was studied in morphine (M)-dependent rats." | 7.66 | Clonidine antagonizes naloxone-induced suppression of conditioned behavior and body weight loss in morphine-dependent rats. ( Meyer, DR; Sparber, SB, 1978) |
| " Therefore, the effect of linalool on morphine dependence and tolerance was studied." | 3.78 | Effect of linalool on morphine tolerance and dependence in mice. ( Hosseini, M; Hosseinzadeh, H; Imenshahidi, M; Razavi, BM, 2012) |
| " The data suggest that partial α(2C)-activation is compatible with effective enhancement of morphine analgesia and reduction both of morphine tolerance acquisition and morphine dependence acquisition and expression." | 3.76 | Fruitful adrenergic α(2C)-agonism/α(2A)-antagonism combination to prevent and contrast morphine tolerance and dependence. ( Cardinaletti, C; Dal Cin, M; Del Bello, F; Ghelfi, F; Giannella, M; Marchioro, C; Mattioli, L; Perfumi, M; Piergentili, A; Pigini, M; Quaglia, W; Thomas, RJ; Zanelli, U, 2010) |
| "Both alpha(2)-adrenoceptors and the L-arginine/nitric oxide (NO) pathway have been implicated in the modulation of morphine dependence." | 3.71 | The effects of simultaneous administration of alpha(2) -adrenergic agents with L-NAME or L-arginine on the development and expression of morphine dependence in mice. ( Fayaz-Dastgerdi, M; Homayoun, H; Khavandgar, S; Zarrindast, MR, 2002) |
| "We examined the effect of morphine dependence on alpha 2-adrenoceptors in guinea-pig brain." | 3.69 | [Changes in alpha 2-adrenoceptor binding nature in guinea-pig brain following the development of morphine dependence]. ( Asano, T; Dohi, S; Niwa, M; Nozaki, M; Ohta, S; Takeda, T, 1997) |
| "The densities of brain alpha 2-adrenoceptors and mu-opioid receptors, quantitated by means of the binding of the agonists [3H]clonidine and [3H]dihydromorphine, respectively, were studied during the development of morphine dependence and spontaneous withdrawal in the rat." | 3.67 | Modulation of brain alpha 2-adrenoceptor and mu-opioid receptor densities during morphine dependence and spontaneous withdrawal in rats. ( García-Sevilla, JA; Ugedo, L; Ulibarri, I, 1987) |
| "The effects of the atypical antidepressant and serotonin antagonist mianserin on the expression of opiate withdrawal was examined using an acute and a chronic model of morphine dependence." | 3.67 | Mianserin attenuates naloxone-precipitated withdrawal signs in rats acutely or chronically dependent upon morphine. ( Neal, BS; Sparber, SB, 1986) |
| "We investigated the effect of morphine dependence on the migrating myoelectric complex (MMC) of the small intestine, whether bacterial overgrowth developed in morphine-dependent rats, and the effect of naloxone, 0." | 3.67 | Myoelectric activity of the small intestine during morphine dependence and withdrawal in rats. ( Kuperman, DA; Lynch, DF; Sninsky, CA, 1987) |
| "Clonidine's action on naloxone (Nx)-induced suppression of fixed-ratio (FR15) responding and body weight loss was studied in morphine (M)-dependent rats." | 3.66 | Clonidine antagonizes naloxone-induced suppression of conditioned behavior and body weight loss in morphine-dependent rats. ( Meyer, DR; Sparber, SB, 1978) |
| " Under pentobarbital anesthesia, precipitated shakes and ice water-induced wet shakes were inhibited by clonidine and norepinephrine." | 3.65 | Effects of clonidine on morphine withdrawal signs in the rat. ( Loh, HH; Tseng, LF; Wei, ET, 1975) |
| "Clonidine was ineffective on the withdrawal signs but decreased body temperature and increased tail flick latency in the tail immersion test in oxytocin pretreated animals." | 1.72 | Effect of oxytocin pretreatment on the development of morphine tolerance and dependence in rats. ( Enginar, N; Gürtekin, B; Midilli, B; Nurten, A; Özdemir-Çezik, S, 2022) |
| " It is concluded that co-administration of Vit B12 and morphine could reduce tolerance to analgesic effect of morphine chronic administration and also reduce its withdrawal symptoms." | 1.40 | Effect of cyanocobalamin (vitamin B12) in the induction and expression of morphine tolerance and dependence in mice. ( Etemad, L; Ghazanfari, S; Hosseinzadeh, H; Imenshahidi, M; Moshiri, M, 2014) |
| "Naloxone was injected (5 mg/kg i." | 1.36 | Effect of Crocus sativus L. (saffron) stigma and its constituents, crocin and safranal, on morphine withdrawal syndrome in mice. ( Hosseinzadeh, H; Jahanian, Z, 2010) |
| "Morphine-treated rats (10 mg/kg/12 h) received naloxone (3." | 1.36 | Precipitated and conditioned withdrawal in morphine-treated rats. ( Becker, GL; France, CP; Gerak, LR; Koek, W; Li, JX, 2010) |
| "The long-term effects of clonidine on withdrawal symptoms and its effects on subsequent drug exposure have not been thoroughly documented." | 1.34 | Clonidine attenuates morphine withdrawal and subsequent drug sensitization in rhesus monkeys. ( Chen, SQ; Cui, YY; Le Foll, B; Lu, L; Shi, J; Zhai, HF, 2007) |
| "Morphine dependence was induced by subcutaneous implantation of morphine pellets." | 1.33 | Role of imidazoline receptors in the anti-aversive properties of clonidine during opiate withdrawal in rats. ( Caillé, S; Georges, F; Le Moine, C; Stinus, L; Vouillac, C, 2005) |
| "Morphine dependence was induced by the implantation of morphine slow-release pellets." | 1.32 | Inhibition of 5-HT neurotransmission increases clonidine protective effects on naloxone-induced conditioned place aversion in morphine-dependent rats. ( Caillé, S; De Deurwaerdère, P; Espejo, EF; Koob, GF; Spampinato, U; Stinus, L, 2003) |
| "The spontaneous neuronal activity of meso-accumbens dopaminergic neurons, identified by antidromical stimulation from the nucleus accumbens, was recorded by use of in vivo extracellular single-unit recordings in control and morphine-withdrawn rats after chronic administration (15 days)." | 1.31 | Clonidine fails to modify dopaminergic neuronal activity during morphine withdrawal. ( Diana, M; Gessa, GL; Gobbi, G; Muntoni, AL, 2001) |
| " We used the tail-flick test to construct dose-response curves before and 4 days after chronic morphine (75-mg pellets, subcutaneously (s." | 1.31 | Reduced development of tolerance to the analgesic effects of morphine and clonidine in PKC gamma mutant mice. ( Basbaum, AI; Gilbert, H; Malmberg, AB; Zeitz, KP, 2001) |
| "Morphine dependence was induced by s." | 1.30 | Total neurochemical lesion of noradrenergic neurons of the locus ceruleus does not alter either naloxone-precipitated or spontaneous opiate withdrawal nor does it influence ability of clonidine to reverse opiate withdrawal. ( Cador, M; Caillé, S; Espejo, EF; Koob, GF; Reneric, JP; Stinus, L, 1999) |
| "Naloxone was paired with the most preferred side and the amount of time spent on this side and on the vehicle-paired side was measured after training." | 1.29 | Clonidine attenuates conditioned aversion produced by naloxone-precipitated opiate withdrawal. ( Kosten, TA, 1994) |
| " The chronic administration of opiates has been associated with a marked sensitization of the adenylyl cyclase/cyclic AMP system, although this phenomenon is not exclusive of the opioid system but the general cellular adaptation to chronic inhibition of adenylyl cyclase." | 1.29 | Loss of protein kinase C-alpha beta in brain of heroin addicts and morphine-dependent rats. ( Busquets, X; Escriba, PV; García-Sevilla, JA; Sastre, M, 1995) |
| "Naloxone treatment induced an increase of plasma beta-END-LI and cortisol levels in morphine-tolerant animals." | 1.28 | Effects of clonidine on pituitary-adrenocortical axis in morphine-tolerant rats and after naloxone-induced withdrawal. ( Arias, L; Bruger, AJ; Gonzalvez, ML; Martinez, JA; Milanés, MV; Vargas, ML, 1992) |
| "Pretreatment with clonidine (200 micrograms/kg, i." | 1.28 | Microdialysis evidence that acetylcholine in the nucleus accumbens is involved in morphine withdrawal and its treatment with clonidine. ( Hoebel, BG; Mark, GP; Pothos, E; Rada, P, 1991) |
| "However, clonidine enhanced many of the withdrawal symptoms in both groups of rats during naltrexone-precipitated withdrawal 1 day after morphine abstinence." | 1.28 | Context-specific morphine withdrawal in rats: duration and effects of clonidine. ( Aranow, JS; Kelsey, JE; Matthews, RT, 1990) |
| "Clonidine was about 12 times more potent than guanfacine in inhibiting this autonomic symptom of withdrawal." | 1.27 | A comparison of the inhibitory effects of clonidine and guanfacine on the behavioral and autonomic components of morphine withdrawal in rats. ( Buccafusco, JJ; Marshall, DC; Turner, RM, 1984) |
| "Treatment with clonidine (100 micrograms/kg s." | 1.27 | Changes in locomotor-activity patterns as a measure of spontaneous morphine withdrawal: no effect of clonidine. ( de Groot, G; van der Laan, JW, 1988) |
| " The slope of the dose-response curves was similar in both strains of rat, but the average response to the same concentrations of clonidine was less in the SHR." | 1.27 | Modification of clonidine-induced pressor responses in morphine-dependent and hypophysectomised rats. ( Conway, EL, 1986) |
| "Clonidine was found to possess dose-dependent analgesic and antiwithdrawal activity." | 1.26 | A comparison of clonidine with morphine for antinociceptive and antiwithdrawal actions. ( Fielding, S; Hynes, M; Lal, H; Novick, WJ; Szewczak, M; Wilker, J, 1978) |
| "Pretreatment with clonidine (50 micrograms/kg, IP) significantly decreased the incidence of 11 out of 16 withdrawal signs." | 1.26 | Clonidine suppresses methylxanthine induced quasi-morphine withdrawal syndrome. ( Grant, SJ; Redmond, DE, 1982) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 50 (51.55) | 18.7374 |
| 1990's | 25 (25.77) | 18.2507 |
| 2000's | 16 (16.49) | 29.6817 |
| 2010's | 5 (5.15) | 24.3611 |
| 2020's | 1 (1.03) | 2.80 |
| Authors | Studies |
|---|---|
| Del Bello, F | 1 |
| Mattioli, L | 1 |
| Ghelfi, F | 1 |
| Giannella, M | 1 |
| Piergentili, A | 1 |
| Quaglia, W | 1 |
| Cardinaletti, C | 1 |
| Perfumi, M | 1 |
| Thomas, RJ | 1 |
| Zanelli, U | 1 |
| Marchioro, C | 1 |
| Dal Cin, M | 1 |
| Pigini, M | 1 |
| Özdemir-Çezik, S | 1 |
| Nurten, A | 1 |
| Midilli, B | 1 |
| Gürtekin, B | 1 |
| Enginar, N | 1 |
| Ghazanfari, S | 1 |
| Imenshahidi, M | 2 |
| Etemad, L | 1 |
| Moshiri, M | 1 |
| Hosseinzadeh, H | 3 |
| Feily, A | 1 |
| Abbasi, N | 1 |
| Jahanian, Z | 1 |
| Becker, GL | 1 |
| Gerak, LR | 1 |
| Li, JX | 1 |
| Koek, W | 1 |
| France, CP | 1 |
| Hosseini, M | 1 |
| Razavi, BM | 1 |
| Nakai, T | 1 |
| Hayashi, M | 1 |
| Ichihara, K | 1 |
| Wakabayashi, H | 1 |
| Hoshi, K | 1 |
| Caillé, S | 4 |
| Stinus, L | 4 |
| Espejo, EF | 3 |
| De Deurwaerdère, P | 1 |
| Spampinato, U | 1 |
| Koob, GF | 4 |
| Georges, F | 2 |
| Aston-Jones, G | 1 |
| Zarrindast, MR | 2 |
| Torkaman-Boutorabi, A | 1 |
| Streel, E | 1 |
| Dan, B | 1 |
| Campanella, S | 1 |
| Meyvaert, A | 1 |
| Hanak, C | 1 |
| Pelc, I | 1 |
| Verbanck, P | 1 |
| Vouillac, C | 1 |
| Le Moine, C | 1 |
| Fathi-Moghaddam, H | 1 |
| Kesmati, M | 1 |
| Kargar, HM | 1 |
| Chen, SQ | 1 |
| Zhai, HF | 1 |
| Cui, YY | 1 |
| Shi, J | 1 |
| Le Foll, B | 1 |
| Lu, L | 1 |
| Collier, HO | 1 |
| Tucker, JF | 1 |
| Beubler, E | 1 |
| Bukhave, K | 1 |
| Rask-Madsen, J | 1 |
| Zigun, JR | 1 |
| Bannon, MJ | 1 |
| Roth, RH | 4 |
| Channabasavanna, SM | 1 |
| Subrahmanya, M | 1 |
| Nakaki, T | 1 |
| Chang, PC | 1 |
| Tokunaga, Y | 1 |
| Kato, R | 1 |
| Buccafusco, JJ | 1 |
| Marshall, DC | 1 |
| Turner, RM | 1 |
| Grant, SJ | 1 |
| Redmond, DE | 3 |
| Aceto, MD | 1 |
| Harris, LS | 1 |
| Britton, KT | 1 |
| Svensson, T | 1 |
| Schwartz, J | 1 |
| Bloom, FE | 1 |
| Babbini, M | 3 |
| Gaiardi, M | 3 |
| Bartoletti, M | 3 |
| Gubellini, C | 3 |
| Bacchi, A | 3 |
| Andrade, R | 1 |
| Vandermaelen, CP | 1 |
| Aghajanian, GK | 2 |
| Cervo, L | 2 |
| Rochat, C | 2 |
| Romandini, S | 1 |
| Samanin, R | 3 |
| Elsworth, JD | 2 |
| Laverty, R | 2 |
| Shearman, GT | 1 |
| Lal, H | 2 |
| Ursillo, RC | 1 |
| Poggesi, E | 1 |
| Mennini, T | 1 |
| Su, T | 1 |
| Sharpe, LG | 1 |
| Schreier, WA | 1 |
| Burks, TF | 1 |
| Fantozzi, R | 1 |
| Luciani, G | 1 |
| Masini, E | 1 |
| Blandina, P | 1 |
| Mannaioni, P | 1 |
| Colado, MI | 3 |
| Alfaro, MJ | 2 |
| Lopez, F | 2 |
| Del Val, V | 1 |
| Martin, MI | 3 |
| Busquets, X | 1 |
| Escriba, PV | 1 |
| Sastre, M | 1 |
| García-Sevilla, JA | 2 |
| Gonzalvez, ML | 2 |
| Milanés, MV | 2 |
| Martinez-Piñero, MG | 1 |
| Marín, MT | 1 |
| Vargas, ML | 2 |
| Kosten, TA | 1 |
| David, C | 1 |
| Davis, N | 1 |
| Mason, R | 2 |
| Wilson, VG | 2 |
| Nader, K | 1 |
| van der Kooy, D | 1 |
| Roerig, SC | 1 |
| Howse, KM | 1 |
| Bristow, LJ | 1 |
| Hogg, JE | 1 |
| Hutson, PH | 1 |
| Ohta, S | 1 |
| Niwa, M | 1 |
| Nozaki, M | 1 |
| Asano, T | 1 |
| Takeda, T | 1 |
| Dohi, S | 1 |
| Mundey, MK | 1 |
| Taylor, JR | 1 |
| Punch, LJ | 1 |
| Ballard, TM | 1 |
| McAllister, KH | 1 |
| Reneric, JP | 1 |
| Cador, M | 1 |
| Hudson, AL | 1 |
| Gough, R | 1 |
| Tyacke, R | 1 |
| Lione, L | 1 |
| Lalies, M | 1 |
| Lewis, J | 1 |
| Husbands, S | 1 |
| Knight, P | 1 |
| Murray, F | 1 |
| Hutson, P | 1 |
| Nutt, DJ | 1 |
| Malin, DH | 1 |
| Lake, JR | 1 |
| Moon, WD | 1 |
| Moy, D | 1 |
| Montellano, AL | 1 |
| Moy, E | 1 |
| Campbell, TD | 1 |
| Bell, MV | 1 |
| Bryant, D | 1 |
| Harrison, LM | 1 |
| Grandy, DK | 1 |
| Gobbi, G | 1 |
| Muntoni, AL | 1 |
| Gessa, GL | 1 |
| Diana, M | 1 |
| Zeitz, KP | 1 |
| Malmberg, AB | 1 |
| Gilbert, H | 1 |
| Basbaum, AI | 1 |
| Jungnickel, S | 1 |
| Chahl, LA | 1 |
| Homayoun, H | 1 |
| Khavandgar, S | 1 |
| Fayaz-Dastgerdi, M | 2 |
| Dehpour, AR | 1 |
| Sadr, SS | 1 |
| Azizi, MR | 1 |
| Namiranian, K | 1 |
| Farahani, M | 1 |
| Javidan, AN | 1 |
| Vetulani, J | 1 |
| Bednarczyk, B | 1 |
| Lipman, JJ | 1 |
| Spencer, PS | 1 |
| Maurset, A | 1 |
| Bratfors, O | 1 |
| Hughes, J | 1 |
| Kosterlitz, HW | 1 |
| Robson, LE | 1 |
| Waterfield, AA | 1 |
| Sparber, SB | 2 |
| Meyer, DR | 1 |
| Fielding, S | 1 |
| Wilker, J | 1 |
| Hynes, M | 1 |
| Szewczak, M | 1 |
| Novick, WJ | 1 |
| Crawley, JN | 1 |
| Tseng, LF | 1 |
| Loh, HH | 1 |
| Wei, ET | 1 |
| Koyuncuŏglu, H | 1 |
| Ariciŏglu, F | 1 |
| Uresin, Y | 1 |
| Dizdar, Y | 1 |
| Esin, Y | 1 |
| van der Laan, JW | 2 |
| Jansen van't Land, C | 1 |
| Silverstone, PH | 2 |
| Done, C | 1 |
| Sharp, T | 1 |
| Schnur, P | 1 |
| Espinoza, M | 1 |
| Flores, R | 1 |
| Ortiz, S | 1 |
| Vallejos, S | 1 |
| Wainwright, M | 1 |
| Attenburrow, MJ | 1 |
| Robson, P | 1 |
| Martinez, JA | 1 |
| Arias, L | 1 |
| Bruger, AJ | 1 |
| Dionyssopoulos, T | 1 |
| Hope, W | 1 |
| Coupar, IM | 1 |
| Rada, P | 1 |
| Pothos, E | 1 |
| Mark, GP | 1 |
| Hoebel, BG | 1 |
| Kelsey, JE | 1 |
| Aranow, JS | 1 |
| Matthews, RT | 1 |
| Smith, CB | 2 |
| Moises, HC | 2 |
| Spengler, RN | 2 |
| Hollingsworth, PJ | 2 |
| Thollander, M | 1 |
| Hellström, PM | 1 |
| Svensson, TH | 2 |
| Alguacil, LF | 1 |
| Alamo, C | 1 |
| Iglesias, V | 1 |
| Cuenca, E | 1 |
| Srivastava, RK | 1 |
| Kaur, AH | 1 |
| Katovich, MJ | 1 |
| Simpkins, JW | 1 |
| Barney, CC | 1 |
| Ulibarri, I | 1 |
| Ugedo, L | 1 |
| Valeri, P | 1 |
| Martinelli, B | 1 |
| Pimpinella, G | 1 |
| Severini, C | 1 |
| Neal, BS | 1 |
| Carlson, KR | 1 |
| Cooper, DO | 1 |
| Kantak, KM | 1 |
| Miczek, KA | 1 |
| Schulz, R | 1 |
| de Groot, G | 1 |
| Kuperman, DA | 1 |
| Sninsky, CA | 1 |
| Lynch, DF | 1 |
| Baeyens, JM | 1 |
| Esposito, E | 1 |
| Ossowska, G | 1 |
| Conway, EL | 1 |
| Gillman, MA | 1 |
| Lichtigfeld, FJ | 1 |
| Holtzman, SG | 1 |
1 review available for clonidine and Morphine Dependence
| Article | Year |
|---|---|
Sites and mechanisms of dependence in the myenteric plexus of guinea pig ileum.
Topics: Acetylcholine; Adenosine; Animals; Clonidine; Cyclic AMP; Guinea Pigs; Humans; Ileum; In Vitro Techn | 1984 |
1 trial available for clonidine and Morphine Dependence
| Article | Year |
|---|---|
The calcium channel antagonist nifedipine causes confusion when used to treat opiate withdrawal in morphine-dependent patients.
Topics: Adult; Clonidine; Confusion; Double-Blind Method; Humans; Male; Methadone; Morphine Dependence; Nife | 1992 |
95 other studies available for clonidine and Morphine Dependence
| Article | Year |
|---|---|
Fruitful adrenergic α(2C)-agonism/α(2A)-antagonism combination to prevent and contrast morphine tolerance and dependence.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Allyl Compounds; Anal | 2010 |
Effect of oxytocin pretreatment on the development of morphine tolerance and dependence in rats.
Topics: Animals; Clonidine; Drug Tolerance; Morphine; Morphine Dependence; Naloxone; Oxytocin; Rats; Recepto | 2022 |
Effect of cyanocobalamin (vitamin B12) in the induction and expression of morphine tolerance and dependence in mice.
Topics: Analgesics, Opioid; Animals; Clonidine; Disease Models, Animal; Dose-Response Relationship, Drug; Dr | 2014 |
The inhibitory effect of Hypericum perforatum extract on morphine withdrawal syndrome in rat and comparison with clonidine.
Topics: Animals; Behavior, Animal; Clonidine; Hypericum; Male; Morphine Dependence; Phytotherapy; Plant Extr | 2009 |
Effect of Crocus sativus L. (saffron) stigma and its constituents, crocin and safranal, on morphine withdrawal syndrome in mice.
Topics: Animals; Carotenoids; Clonidine; Crocus; Cyclohexenes; Male; Mice; Morphine; Morphine Dependence; Mo | 2010 |
Precipitated and conditioned withdrawal in morphine-treated rats.
Topics: Animals; Body Weight; Clonidine; Conditioning, Classical; Male; Morphine; Morphine Dependence; Nalox | 2010 |
Effect of linalool on morphine tolerance and dependence in mice.
Topics: Acyclic Monoterpenes; Analgesics, Opioid; Animals; Clonidine; Drug Tolerance; Male; Mice; Monoterpen | 2012 |
Noradrenaline release in rat locus coeruleus is regulated by both opioid and alpha(2) -adrenoceptors.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Agon | 2002 |
Inhibition of 5-HT neurotransmission increases clonidine protective effects on naloxone-induced conditioned place aversion in morphine-dependent rats.
Topics: Animals; Avoidance Learning; Clonidine; Conditioning, Psychological; Dose-Response Relationship, Dru | 2003 |
Prolonged activation of mesolimbic dopaminergic neurons by morphine withdrawal following clonidine: participation of imidazoline and norepinephrine receptors.
Topics: Animals; Clonidine; Dopamine; Imidazoline Receptors; Limbic System; Morphine Dependence; Neurons; Ra | 2003 |
Effects of imipramine on the expression and development of morphine dependence in mice.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Adrenergic Uptake Inhibitors; Animals; Clon | 2003 |
A pharmacological modulation of opiate withdrawal using an up-/down-regulation of the noradrenergic system in opiate-dependent rats.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Analysis of Variance; Animals; Behavior, An | 2006 |
Role of imidazoline receptors in the anti-aversive properties of clonidine during opiate withdrawal in rats.
Topics: Adrenergic alpha-Agonists; Animals; Avoidance Learning; Behavior, Animal; Clonidine; Conditioning, O | 2005 |
The effect of paragigantocellularis lateralis lesion on conditioned place preference (CPP) in presence or absence of alpha2 adrenergic agonist (clonidine) in male rats.
Topics: Adrenergic alpha-Agonists; Analgesics, Opioid; Animals; Behavior, Animal; Brain Stem; Clonidine; Mal | 2006 |
Clonidine attenuates morphine withdrawal and subsequent drug sensitization in rhesus monkeys.
Topics: Adrenergic alpha-Agonists; Animals; Behavior, Animal; Clonidine; Cocaine; Macaca mulatta; Male; Morp | 2007 |
Colonic secretion mediated by prostaglandin E2 and 5-hydroxytryptamine may contribute to diarrhea due to morphine withdrawal in the rat.
Topics: Animals; Atropine; Clonidine; Colon; Cyclic AMP; Diarrhea; Dinoprostone; Female; Humans; Indomethaci | 1984 |
Comparison of two alpha-noradrenergic agonists (clonidine and guanfacine) on norepinephrine turnover in the cortex of rats during morphine abstinence.
Topics: Adrenergic alpha-Agonists; Animals; Cerebral Cortex; Clonidine; Dose-Response Relationship, Drug; Gu | 1981 |
Clonidine for opiate withdrawal.
Topics: Adult; Clonidine; Humans; Male; Morphine Dependence; Substance Withdrawal Syndrome | 1981 |
alpha 2-adrenoceptors modulating diarrhoea in morphine-dependent rats.
Topics: Animals; Clonidine; Diarrhea; Humans; Male; Morphine Dependence; Naloxone; Rats; Receptors, Adrenerg | 1981 |
A comparison of the inhibitory effects of clonidine and guanfacine on the behavioral and autonomic components of morphine withdrawal in rats.
Topics: Adrenergic alpha-Agonists; Animals; Autonomic Nervous System; Behavior, Animal; Blood Pressure; Clon | 1984 |
Clonidine suppresses methylxanthine induced quasi-morphine withdrawal syndrome.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Behavior, Animal; Clonidine; Humans; Male; Morphine Dependence | 1982 |
Clonidine and the primate locus coeruleus: evidence suggesting anxiolytic and anti-withdrawal effects.
Topics: Animals; Anxiety; Clonidine; Electric Stimulation; Emotions; Fear; Haplorhini; Humans; Locus Coerule | 1981 |
Antinociceptive mechanism and acute and chronic behavioral effects of clonidine.
Topics: Animals; Behavior, Animal; Clonidine; Female; Humans; Macaca mulatta; Male; Morphine; Morphine Depen | 1981 |
Dorsal noradrenergic bundle lesions fail to alter opiate withdrawal or suppression of opiate withdrawal by clonidine.
Topics: Animals; Brain Chemistry; Clonidine; Dopamine; Humans; Locus Coeruleus; Male; Morphine Dependence; N | 1984 |
Stimulus properties of clonidine in chronically morphine treated rats trained to a morphine-saline discrimination.
Topics: Animals; Clonidine; Discrimination Learning; Generalization, Stimulus; Humans; Male; Morphine Depend | 1984 |
Morphine tolerance and dependence in the locus coeruleus: single cell studies in brain slices.
Topics: Animals; Clonidine; Drug Tolerance; Humans; In Vitro Techniques; Locus Coeruleus; Male; Morphine; Mo | 1983 |
Evidence of a preferential role of brain serotonin in the mechanisms leading to naloxone-precipitated compulsive jumping in morphine-dependent rats.
Topics: Animals; Behavior, Animal; Brain; Clonidine; Humans; Male; Morphine Dependence; Naloxone; Piperoxan; | 1981 |
Clonidine suppression of noradrenergic hyperactivity during morphine withdrawal by clonidine: biochemical studies in rodents and primates.
Topics: Animals; Brain; Clonidine; Dose-Response Relationship, Drug; Haplorhini; Humans; Methoxyhydroxypheny | 1982 |
Clonidine reverses the increased norepinephrine turnover during morphine withdrawal in rats.
Topics: Animals; Brain; Clonidine; Dose-Response Relationship, Drug; Humans; Male; Methyltyrosines; Morphine | 1980 |
Effectiveness of lofexidine in blocking morphine-withdrawal signs in the rat.
Topics: Animals; Behavior, Animal; Clonidine; Diarrhea; Dose-Response Relationship, Drug; Humans; Male; Morp | 1980 |
Reduction in the number of serotonin receptors in the brainstem of morphine dependent rats: relation to blockade of naloxone precipitated jumping by serotonin agonists.
Topics: Animals; Behavior, Animal; Brain Stem; Clonidine; Haloperidol; Humans; Male; Morphine Dependence; Na | 1980 |
Characteristics of oscillatory contractions elicited by naloxone in ileum preparation from morphine-dependent guinea pigs.
Topics: Acetylcholine; Animals; Clonidine; Guinea Pigs; Humans; Ileum; In Vitro Techniques; Male; Morphine D | 1980 |
Suppression of morphine withdrawal diarrhea by clonidine.
Topics: Animals; Clonidine; Diarrhea; Digestive System; Female; Humans; Morphine Dependence; Naloxone; Neost | 1981 |
Clonidine and naloxone-induced opiate withdrawal: a comparison between clonidine and morphine in man.
Topics: Clonidine; Female; Humans; Male; Morphine; Morphine Dependence; Naloxone; Substance Withdrawal Syndr | 1980 |
Effect of nimodipine, diltiazem and BAY K 8644 on the behavioural and neurochemical changes associated with naloxone-precipitated withdrawal in the rat. A comparison with clonidine.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1993 |
Loss of protein kinase C-alpha beta in brain of heroin addicts and morphine-dependent rats.
Topics: Adenylyl Cyclases; Adult; Animals; Brain; Clonidine; Heroin Dependence; Humans; Immunoblotting; Male | 1995 |
Effects of intracerebroventricular clonidine on the hypothalamic noradrenaline and plasma corticosterone levels of opiate naive rats and after naloxone-induced withdrawal.
Topics: Animals; Clonidine; Corticosterone; Hypothalamus; Injections, Intraventricular; Male; Morphine Depen | 1994 |
Clonidine attenuates conditioned aversion produced by naloxone-precipitated opiate withdrawal.
Topics: Animals; Avoidance Learning; Clonidine; Dose-Response Relationship, Drug; Male; Morphine; Morphine D | 1994 |
Evidence for functional dissociation of dependence and tolerance in guinea-pig isolated ileal segments following 20 hour exposure to morphine in vitro.
Topics: Animals; Clonidine; Drug Tolerance; Female; Guinea Pigs; Ileum; In Vitro Techniques; Male; Morphine; | 1993 |
Clonidine antagonizes the aversive effects of opiate withdrawal and the rewarding effects of morphine only in opiate withdrawn rats.
Topics: Adrenergic alpha-Agonists; Animals; Arousal; Association Learning; Avoidance Learning; Clonidine; Co | 1996 |
Omega-agatoxin IVA blocks spinal morphine/clonidine antinociceptive synergism.
Topics: Analgesics, Opioid; Animals; Calcium Channel Blockers; Clonidine; Drug Synergism; Drug Tolerance; Li | 1996 |
Competitive and glycine/NMDA receptor antagonists attenuate withdrawal-induced behaviours and increased hippocampal acetylcholine efflux in morphine-dependent rats.
Topics: Acetylcholine; Adrenergic alpha-Agonists; Animals; Behavior, Animal; Binding, Competitive; Clonidine | 1997 |
[Changes in alpha 2-adrenoceptor binding nature in guinea-pig brain following the development of morphine dependence].
Topics: Adrenergic alpha-Agonists; Animals; Brain; Clonidine; Guinea Pigs; Male; Morphine; Morphine Dependen | 1997 |
Selective potentiation by ouabain of naloxone-induced withdrawal contractions of isolated guinea-pig ileum following acute exposure to morphine.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Carbachol; Clonidine; Drug Synergi | 1998 |
A comparison of the effects of clonidine and CNQX infusion into the locus coeruleus and the amygdala on naloxone-precipitated opiate withdrawal in the rat.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Adrenergic alpha-Agonists; Amygdala; Animals; Clonidine; Excit | 1998 |
Acutely administered clozapine does not modify naloxone-induced withdrawal jumping in morphine-dependent mice.
Topics: Analgesics; Animals; Antipsychotic Agents; Clonidine; Clozapine; Haloperidol; Male; Mice; Morphine D | 1999 |
Total neurochemical lesion of noradrenergic neurons of the locus ceruleus does not alter either naloxone-precipitated or spontaneous opiate withdrawal nor does it influence ability of clonidine to reverse opiate withdrawal.
Topics: Adrenergic alpha-Agonists; Animals; Avoidance Learning; Brain; Clonidine; Dopamine; Locus Coeruleus; | 1999 |
Novel selective compounds for the investigation of imidazoline receptors.
Topics: Animals; Autoradiography; Binding Sites; Blood-Brain Barrier; Brain; Clonidine; Dogs; Humans; Imidaz | 1999 |
Nociceptin/orphanin FQ (N/OFQ) induces a quasi-morphine abstinence syndrome in the rat.
Topics: Animals; Clonidine; Dose-Response Relationship, Drug; Male; Morphine; Morphine Dependence; Nocicepti | 2000 |
Clonidine fails to modify dopaminergic neuronal activity during morphine withdrawal.
Topics: Action Potentials; Adrenergic alpha-Agonists; Animals; Clonidine; Dopamine; Dose-Response Relationsh | 2001 |
Reduced development of tolerance to the analgesic effects of morphine and clonidine in PKC gamma mutant mice.
Topics: Analgesics; Analgesics, Opioid; Animals; Clonidine; Drug Tolerance; Hyperalgesia; Isoenzymes; Male; | 2001 |
The effect of clonidine on the naltrexone-induced withdrawal response in morphine-treated guinea-pigs.
Topics: Adrenergic alpha-Agonists; Animals; Brain; Clonidine; Female; Genes, fos; Guinea Pigs; Male; Morphin | 2002 |
The effects of simultaneous administration of alpha(2) -adrenergic agents with L-NAME or L-arginine on the development and expression of morphine dependence in mice.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Agon | 2002 |
Dorsal and median raphe serotonergic system lesion does not alter the opiate withdrawal syndrome.
Topics: 5,7-Dihydroxytryptamine; Adrenergic alpha-Agonists; Animals; Behavior, Animal; Biogenic Amines; Clon | 2002 |
Lithium inhibits the development of physical dependence to clonidine in mice.
Topics: Administration, Oral; Adrenergic alpha-Antagonists; Animals; Clonidine; Injections, Intraperitoneal; | 2002 |
Depression by clonidine of shaking behaviour elicited by nalorphine in morphine-dependent rats.
Topics: Animals; Clonidine; Cyproheptadine; Humans; Male; Morphine Dependence; Nalorphine; Rats; Substance W | 1977 |
Clonidine and opiate withdrawal.
Topics: Animals; Clonidine; Drug Evaluation; Drug Interactions; Humans; Male; Morphine Dependence; Rats; Sub | 1978 |
Tolerance of locus coeruleus neurones to morphine and suppression of withdrawal response by clonidine.
Topics: Action Potentials; Animals; Clonidine; Humans; Locus Coeruleus; Male; Morphine; Morphine Dependence; | 1978 |
[Clonidine in opiate abstinence].
Topics: Clonidine; Heroin Dependence; Humans; Morphine Dependence; Substance Withdrawal Syndrome | 1979 |
The inhibitory effects of clonidine on the contractions of the guinea-pig ileum in the morphine-dependent and withdrawn states [proceedings].
Topics: Animals; Clonidine; Depression, Chemical; Guinea Pigs; Humans; Ileum; In Vitro Techniques; Morphine | 1978 |
Clonidine antagonizes naloxone-induced suppression of conditioned behavior and body weight loss in morphine-dependent rats.
Topics: Animals; Body Weight; Clonidine; Conditioning, Operant; Dose-Response Relationship, Drug; Humans; Ma | 1978 |
A comparison of clonidine with morphine for antinociceptive and antiwithdrawal actions.
Topics: Analgesics; Animals; Clonidine; Female; Humans; Male; Mice; Morphine; Morphine Dependence; Pressure; | 1978 |
Clonidine reversal of increased norepinephrine metabolite levels during morphine withdrawal.
Topics: Animals; Clonidine; Humans; Locus Coeruleus; Male; Methoxyhydroxyphenylglycol; Morphine Dependence; | 1979 |
Effects of clonidine on morphine withdrawal signs in the rat.
Topics: Anesthesia; Animals; Body Temperature; Cerebral Ventricles; Clonidine; Escape Reaction; Exophthalmos | 1975 |
Effects of opioid and alpha 2-adrenoceptor agonists on the isolated ileum of morphine-dependent guinea-pigs during withdrawal and after clonidine treatment.
Topics: Adrenergic alpha-Agonists; Animals; Clonidine; Drug Tolerance; Electric Stimulation; Guinea Pigs; Il | 1992 |
Effects of tizanidine on morphine physical dependence: attenuation and intensification.
Topics: Adrenergic alpha-Agonists; Analgesics; Animals; Aspartic Acid; Behavior, Animal; Clonidine; Glutamat | 1992 |
Chronic infusion of clonidine does not alleviate spontaneous morphine withdrawal symptoms in rats.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Brimonidine Tartrate; Clonidine; D | 1992 |
Clonidine but not nifedipine prevents the release of noradrenaline during naloxone-precipitated opiate withdrawal: an in vivo microdialysis study in the rat.
Topics: Animals; Behavior, Animal; Clonidine; Male; Microdialysis; Morphine Dependence; Naloxone; Nifedipine | 1992 |
Blocking naloxone-precipitated withdrawal in rats and hamsters.
Topics: Animals; Behavior, Animal; Clonidine; Cricetinae; Drug Implants; Mesocricetus; Morphine Dependence; | 1992 |
Effects of clonidine on pituitary-adrenocortical axis in morphine-tolerant rats and after naloxone-induced withdrawal.
Topics: Animals; beta-Endorphin; Clonidine; Female; Hydrocortisone; Male; Morphine Dependence; Naloxone; Pit | 1992 |
Effect of adenosine analogues on the expression of opiate withdrawal in rats.
Topics: Adenosine; Animals; Behavior, Animal; Clonidine; Diarrhea; Female; Male; Morphine Dependence; Motor | 1992 |
Microdialysis evidence that acetylcholine in the nucleus accumbens is involved in morphine withdrawal and its treatment with clonidine.
Topics: Acetylcholine; Animals; Clonidine; Dialysis; Male; Morphine; Morphine Dependence; Naloxone; Nucleus | 1991 |
Effect of clonidine, nimodipine and diltiazem on the in vitro opioid withdrawal response in the guinea-pig ileum.
Topics: Animals; Clonidine; Diltiazem; Electric Stimulation; Guinea Pigs; Ileum; In Vitro Techniques; Morphi | 1990 |
Context-specific morphine withdrawal in rats: duration and effects of clonidine.
Topics: Animals; Arousal; Association Learning; Clonidine; Male; Morphine; Morphine Dependence; Motor Activi | 1990 |
Changes in alpha 2-adrenoceptor number and function in brains of morphine-dependent rats.
Topics: Animals; Brain Chemistry; Clonidine; Electric Stimulation; Hippocampus; Male; Membranes; Morphine De | 1989 |
Cross-tolerance between morphine and clonidine: a study on motility in rats.
Topics: Animals; Clonidine; Drug Tolerance; Male; Morphine; Morphine Dependence; Motor Activity; Rats; Rats, | 1989 |
Suppression of small intestinal motility and morphine withdrawal diarrhoea by clonidine: peripheral site of action.
Topics: Animals; Clonidine; Diarrhea; Gastrointestinal Motility; Intestine, Small; Male; Morphine; Morphine | 1989 |
An automated method for the evaluation of jumping activity in mice. Effects of clonidine on morphine withdrawal.
Topics: Animals; Clonidine; Male; Mice; Morphine Dependence; Motor Activity; Naloxone; Substance Withdrawal | 1989 |
Failure of reversal of cardiovascular responses of clonidine by centrally administered naloxone in anaesthetised rats.
Topics: Anesthesia; Animals; Blood Pressure; Clonidine; Desoxycorticosterone; Female; Heart Rate; Hypertensi | 1989 |
Alpha-adrenergic mediation of the tail skin temperature response to naloxone in morphine-dependent rats.
Topics: Animals; Body Temperature; Brain; Clonidine; Female; Morphine Dependence; Naloxone; Phentolamine; Ra | 1987 |
Presynaptic alpha 2 adrenoreceptor function in dependent rats before and after morphine withdrawal.
Topics: Animals; Clonidine; Hippocampus; In Vitro Techniques; Male; Morphine; Morphine Dependence; Norepinep | 1986 |
Modulation of brain alpha 2-adrenoceptor and mu-opioid receptor densities during morphine dependence and spontaneous withdrawal in rats.
Topics: Animals; Brain; Brain Stem; Cerebral Cortex; Clonidine; Corpus Striatum; Dihydromorphine; Hypothalam | 1987 |
Effects of dapiprazole, clonidine and yohimbine on the development of dependence and withdrawal behaviour in mice.
Topics: Animals; Behavior, Animal; Brain; Clonidine; Dose-Response Relationship, Drug; Injections, Intravent | 1989 |
Mianserin attenuates naloxone-precipitated withdrawal signs in rats acutely or chronically dependent upon morphine.
Topics: Animals; Body Temperature; Clonidine; Corticosterone; Dibenzazepines; Male; Mianserin; Morphine Depe | 1986 |
Morphine dependence and protracted abstinence: regional alterations in CNS radioligand binding.
Topics: Animals; Brain Chemistry; Clonidine; Dihydroalprenolol; Male; Morphine Dependence; Radioligand Assay | 1985 |
Social, motor, and autonomic signs of morphine withdrawal: differential sensitivities to catecholaminergic drugs in mice.
Topics: Animals; Apomorphine; Autonomic Nervous System; Catecholamines; Clonidine; Cocaine; Dextroamphetamin | 1988 |
Dependence and cross-dependence in the guinea-pig myenteric plexus.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics | 1988 |
Changes in locomotor-activity patterns as a measure of spontaneous morphine withdrawal: no effect of clonidine.
Topics: Animals; Body Weight; Clonidine; Eating; Male; Morphine; Morphine Dependence; Motor Activity; Rats; | 1988 |
Myoelectric activity of the small intestine during morphine dependence and withdrawal in rats.
Topics: Animals; Clonidine; Electromyography; Intestine, Small; Morphine Dependence; Muscle, Smooth; Naloxon | 1987 |
Effects of peripheral and central administration of calcium channel blockers in the naloxone-precipitated abstinence syndrome in morphine-dependent rats.
Topics: Animals; Body Weight; Brain; Calcium Channel Blockers; Clonidine; Diarrhea; Flunarizine; Injections, | 1987 |
Modification of clonidine-induced pressor responses in morphine-dependent and hypophysectomised rats.
Topics: Animals; Blood Pressure; Clonidine; Dose-Response Relationship, Drug; Hypertension; Hypophysectomy; | 1986 |
Clonidine treatment in vegetative dysfunction--experimental rationales.
Topics: Animals; Behavior, Animal; Brain; Climacteric; Clonidine; Female; Hemodynamics; Humans; Locus Coerul | 1985 |
Analgesic nitrous oxide: adjunct to clonidine for opioid withdrawal.
Topics: Adult; Clonidine; Drug Therapy, Combination; Female; Humans; Meperidine; Morphine; Morphine Dependen | 1985 |
Discriminative stimulus effects of morphine withdrawal in the dependent rat: suppression by opiate and nonopiate drugs.
Topics: Animals; Body Weight; Clonidine; Haloperidol; Humans; Male; Morphine Dependence; Naloxone; Naltrexon | 1985 |
Morphine and clonidine oral self-administration: a study in morphine dependent or abstinent rats.
Topics: Animals; Clonidine; Conditioning, Operant; Humans; Male; Morphine; Morphine Dependence; Rats; Rats, | 1985 |