clonidine has been researched along with Metabolic Syndrome in 8 studies
Clonidine: An imidazoline sympatholytic agent that stimulates ALPHA-2 ADRENERGIC RECEPTORS and central IMIDAZOLINE RECEPTORS. It is commonly used in the management of HYPERTENSION.
clonidine (amino form) : A clonidine that is 4,5-dihydro-1H-imidazol-2-amine in which one of the amino hydrogens is replaced by a 2,6-dichlorophenyl group.
Metabolic Syndrome: A cluster of symptoms that are risk factors for CARDIOVASCULAR DISEASES and TYPE 2 DIABETES MELLITUS. The major components of metabolic syndrome include ABDOMINAL OBESITY; atherogenic DYSLIPIDEMIA; HYPERTENSION; HYPERGLYCEMIA; INSULIN RESISTANCE; a proinflammatory state; and a prothrombotic (THROMBOSIS) state.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Similar responses were observed after oral dosing and in lean littermates." | 1.32 | The role of I(1)-imidazoline and alpha(2)-adrenergic receptors in the modulation of glucose metabolism in the spontaneously hypertensive obese rat model of metabolic syndrome X. ( Ernsberger, P; Velliquette, RA, 2003) |
| "LZR." | 1.32 | Enhanced arteriolar alpha-adrenergic constriction impairs dilator responses and skeletal muscle perfusion in obese Zucker rats. ( Frisbee, JC, 2004) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (37.50) | 29.6817 |
| 2010's | 5 (62.50) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Gasparik, V | 1 |
| Greney, H | 1 |
| Schann, S | 1 |
| Feldman, J | 1 |
| Fellmann, L | 1 |
| Ehrhardt, JD | 1 |
| Bousquet, P | 3 |
| Katare, PB | 1 |
| Banerjee, SK | 1 |
| Nascimento, AR | 1 |
| Machado, MV | 1 |
| Gomes, F | 2 |
| Vieira, AB | 1 |
| Gonçalves-de-Albuquerque, CF | 1 |
| Lessa, MA | 1 |
| Tibiriçá, E | 2 |
| Estato, V | 1 |
| Nascimento, A | 1 |
| Antunes, B | 1 |
| Coelho, L | 1 |
| Rangel, R | 1 |
| Garzoni, L | 1 |
| Daliry, A | 1 |
| Limberg, JK | 1 |
| Morgan, BJ | 1 |
| Sebranek, JJ | 1 |
| Proctor, LT | 1 |
| Walker, BJ | 1 |
| Eldridge, MW | 1 |
| Schrage, WG | 1 |
| Velliquette, RA | 2 |
| Ernsberger, P | 2 |
| Frisbee, JC | 1 |
| Kossover, R | 1 |
| Previs, SF | 1 |
1 review available for clonidine and Metabolic Syndrome
| Article | Year |
|---|---|
Repositioning of Drugs in Cardiometabolic Disorders: Importance and Current Scenario.
Topics: Allopurinol; Aspirin; Bromocriptine; Cardiovascular Diseases; Clonidine; Colesevelam Hydrochloride; | 2016 |
1 trial available for clonidine and Metabolic Syndrome
| Article | Year |
|---|---|
Altered neurovascular control of the resting circulation in human metabolic syndrome.
Topics: Adolescent; Adrenergic alpha-1 Receptor Agonists; Adrenergic alpha-2 Receptor Agonists; Adult; Cloni | 2012 |
6 other studies available for clonidine and Metabolic Syndrome
| Article | Year |
|---|---|
Synthesis and biological evaluation of 2-aryliminopyrrolidines as selective ligands for I1 imidazoline receptors: discovery of new sympatho-inhibitory hypotensive agents with potential beneficial effects in metabolic syndrome.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Blood-Brain Barrier; Drug Discovery; Heart Rate; I | 2015 |
Central Sympathetic Modulation Reverses Microvascular Alterations in a Rat Model of High-Fat Diet-Induced Metabolic Syndrome.
Topics: Adrenergic alpha-Agonists; Animals; Clonidine; Diet, High-Fat; Intravital Microscopy; Male; Metaboli | 2016 |
Cerebral Microvascular Dysfunction and Inflammation Are Improved by Centrally Acting Antihypertensive Drugs in Metabolic Syndrome.
Topics: Aniline Compounds; Animals; Antihypertensive Agents; Brain; Cerebrovascular Circulation; Clonidine; | 2017 |
The role of I(1)-imidazoline and alpha(2)-adrenergic receptors in the modulation of glucose metabolism in the spontaneously hypertensive obese rat model of metabolic syndrome X.
Topics: Adrenergic alpha-2 Receptor Antagonists; Animals; Clonidine; Disease Models, Animal; Female; Glucose | 2003 |
Enhanced arteriolar alpha-adrenergic constriction impairs dilator responses and skeletal muscle perfusion in obese Zucker rats.
Topics: Adrenergic alpha-Agonists; Animals; Arterioles; Clonidine; Male; Metabolic Syndrome; Muscle, Skeleta | 2004 |
Lipid-lowering actions of imidazoline antihypertensive agents in metabolic syndrome X.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Agon | 2006 |