clonidine has been researched along with Malignant Hypertension in 27 studies
Clonidine: An imidazoline sympatholytic agent that stimulates ALPHA-2 ADRENERGIC RECEPTORS and central IMIDAZOLINE RECEPTORS. It is commonly used in the management of HYPERTENSION.
clonidine (amino form) : A clonidine that is 4,5-dihydro-1H-imidazol-2-amine in which one of the amino hydrogens is replaced by a 2,6-dichlorophenyl group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Nineteen patients with severe essential hypertension or hypertension due to renal parenchymal disease were treated with intravenous clonidine." | 7.66 | Evaluation of intravenous clonidine in hypertensive emergencies. ( Niarchos, AP, 1978) |
| "Nineteen patients with severe essential hypertension or hypertension due to renal parenchymal disease were treated with intravenous clonidine." | 3.66 | Evaluation of intravenous clonidine in hypertensive emergencies. ( Niarchos, AP, 1978) |
| " In seventeen patients with untreated essential hypertension the sodium and water contents of leucocytes were significantly increased, whereas the rate constant for ouabain-sensitive sodium efflux was significantly reduced." | 3.65 | Abnormal sodium transport in leucocytes from patients with essential hypertension and the effect of treatment. ( Edmondson, RP; Hilton, PJ; Jones, NF; Thomas, RD, 1975) |
| "A patient who underwent cardiopulmonary bypass developed a syndrome of malignant hypertension with agitated delirium, unresponsive to antihypertensive agents, following abrupt withdrawal of clonidine." | 3.65 | Acute clonidine withdrawal syndrome following open-heart operation. ( Brenner, WI; Lieberman, AN, 1977) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 25 (92.59) | 18.7374 |
| 1990's | 1 (3.70) | 18.2507 |
| 2000's | 1 (3.70) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Stiefelhagen, P | 1 |
| Adler, LE | 1 |
| Bell, J | 1 |
| Kirch, D | 1 |
| Friedrich, E | 1 |
| Freedman, R | 1 |
| Moyer, JH | 2 |
| Mitchell, HC | 1 |
| Pettinger, WA | 1 |
| Ram, CV | 2 |
| Leroux-Robert, C | 1 |
| Charmes, JP | 1 |
| Benevent, D | 1 |
| Rince, M | 1 |
| Grim, CE | 1 |
| Thomas, RD | 1 |
| Edmondson, RP | 1 |
| Hilton, PJ | 1 |
| Jones, NF | 1 |
| Reza, MJ | 1 |
| Binde ki Muaka, P | 1 |
| Proesmans, W | 1 |
| Strauss, FG | 1 |
| Franklin, SS | 1 |
| Lewin, AJ | 1 |
| Maxwell, MH | 1 |
| Niarchos, AP | 1 |
| Haas, Th | 1 |
| Denkl, P | 1 |
| Brenner, WI | 1 |
| Lieberman, AN | 1 |
| Frolich, JC | 1 |
| Blumberg, A | 1 |
| Studer, U | 1 |
| Briner, J | 1 |
| Stelzer, FP | 1 |
| Stubebbord, JJ | 1 |
| Screenivasan, V | 1 |
| Venuto, RC | 1 |
| Tebloev, KI | 1 |
| Kharchenko, VI | 1 |
| Dergacheva, IuG | 1 |
| Kiseleva, NG | 1 |
| Petraneva, EV | 1 |
| Nasedkin, VS | 1 |
| Pashedko, MA | 1 |
| Baranova, OS | 1 |
| Ferguson, RK | 1 |
| Vlasses, PH | 1 |
| Meese, RB | 1 |
| Burris, JF | 1 |
| Philipp, T | 1 |
| Nast, HP | 1 |
| Lubbe, WF | 1 |
| Safar, M | 1 |
| Milliez, P | 1 |
| Raftos, J | 1 |
| Bauer, GE | 1 |
| Lewis, RG | 1 |
| Stokes, GS | 1 |
| Mitchell, AS | 1 |
| Young, AA | 1 |
| Maclachlan, I | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Hemodynamic Effect of Intrathecal Clonidine in Hypertensive Subjects: A Pilot Study to Assess Its Effectiveness in Hypertensive Subjects With Poor Blood Pressure Control (Phase II)[NCT01297335] | Phase 2 | 10 participants (Actual) | Interventional | 2011-02-28 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
"Subjects baseline blood pressure (systolic blood pressure (SBP), and diastolic blood pressure (DBP)), and blood pressures after clonidine injection was compared against baseline to assess efficacy of clonidine in refractory hypertensive subjects. Subject's blood pressure was monitored continuously after intrathecal injection of clonidine until subjects blood pressure nadir and return to pre clonidine injection level. The mean value reported below are the average changes in blood pressure from baseline (pre clonidine injection) in both SBP and DBP during post clonidine injection blood pressure monitoring for 4 hours.~Blood pressure measurements were collected every 10 minutes for first hour after injection, and every 15 minutes after the first hour, up to 4 hours were averaged to report the change from baseline." (NCT01297335)
Timeframe: Baseline, Every 10 Minutes for first hour after clonidine injection, and every 15 minutes after first hour, until 4 hours after clonidine injection
| Intervention | mm Hg (Mean) | |
|---|---|---|
| Change in mean SBP after clonidine injection | Change in DBP after clonidine injection | |
| Intrathecal Clonidine | 79 | 37 |
Subjects were asked to rate severity of two of the most common side effects of clonidine, sedation and sensation of dry mouth, at pre and post (1 hour after) intrathecal administration of clonidine. The mean changes between pre and post injection VAS ratings of sedation and sensation of dry mouth are reported below. The VAS scale ranges from 1 to 10 cm, with higher values indicating higher level of sedation and higher level of dry mouth. (NCT01297335)
Timeframe: Before clonidine injection (Baseline), and at 1 hour after clonidine injection.
| Intervention | cm (Mean) | |
|---|---|---|
| Change in level of sedation | Change in sensation of dry mouth | |
| Intrathecal Clonidine | 3.36 | 3.47 |
Likert scale is 11 point digital pain rating system that asks subjects to rate their pain from 0 to 10. Rating of 0 means no pain at all, and in increasing order, 10 would mean worst pain imaginable/ unbearable pain. (NCT01297335)
Timeframe: Pre-dose and 1 hour post injection.
| Intervention | units on a scale (Mean) | |
|---|---|---|
| Pre-injection average Likert score | Post-injection average Likert score | |
| Intrathecal Clonidine | 6.5 | 3.6 |
4 reviews available for clonidine and Malignant Hypertension
| Article | Year |
|---|---|
Drug systems approach to hypertension.
Topics: Captopril; Clonidine; Drug Combinations; Drug Therapy, Combination; Guanethidine; Humans; Hydralazin | 1984 |
Hypertensive crisis.
Topics: Antihypertensive Agents; Brain Diseases; Cerebrovascular Disorders; Clonidine; Coronary Disease; Dia | 1984 |
Hypertensive emergencies and urgencies.
Topics: Adult; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Calcium Channel Blockers; | 1986 |
Hypertensive cardiovascular emergencies.
Topics: Antihypertensive Agents; Brain Diseases; Cerebrovascular Disorders; Clonidine; Coronary Disease; Dia | 1985 |
2 trials available for clonidine and Malignant Hypertension
| Article | Year |
|---|---|
[Multicomponent therapy of severe arterial hypertension in a hospital].
Topics: Adult; Aged; Antihypertensive Agents; Blood Pressure; Clonidine; Dose-Response Relationship, Drug; D | 1991 |
Clonidine in the management of uncontrolled hypertension.
Topics: Adult; Aged; Clinical Trials as Topic; Clonidine; Female; Follow-Up Studies; Humans; Hypertension; H | 1974 |
21 other studies available for clonidine and Malignant Hypertension
| Article | Year |
|---|---|
[When hypertension becomes an emergency case: lower the blood pressure, but slowly!].
Topics: Administration, Oral; Antihypertensive Agents; Calcium Channel Blockers; Clonidine; Diagnosis, Diffe | 2003 |
Psychosis associated with clonidine withdrawal.
Topics: Adult; Antipsychotic Agents; Bipolar Disorder; Clonidine; Female; Humans; Hypertension, Malignant; M | 1982 |
Use of sympatholytic and vasodilator drugs.
Topics: Adrenergic beta-Antagonists; Clonidine; Diuretics; Drug Therapy, Combination; Guanethidine; Humans; | 1984 |
Renal function in long-term minoxidil-treated patients.
Topics: Adult; Blood Pressure; Clonidine; Creatinine; Diuretics; Female; Humans; Hypertension; Hypertension, | 1980 |
[Treatment of malignant arterial hypertension].
Topics: Acute Kidney Injury; Clonidine; Diazoxide; Dihydralazine; Diuretics; Humans; Hypertension, Malignant | 1980 |
Management of malignant hypertension.
Topics: Administration, Oral; Antihypertensive Agents; Blood Pressure; Clonidine; Diazoxide; Diuretics; Drug | 1980 |
The general management of hypertension.
Topics: Adrenergic beta-Antagonists; Aged; Animals; Antihypertensive Agents; Benzothiadiazines; Clonidine; D | 1976 |
Abnormal sodium transport in leucocytes from patients with essential hypertension and the effect of treatment.
Topics: Adrenergic beta-Antagonists; Benzothiadiazines; Biological Transport, Active; Blood Pressure; Clonid | 1975 |
Clonidine-withdrawal syndrome.
Topics: Clonidine; Humans; Hypertension; Hypertension, Malignant; Nitroprusside; Substance Withdrawal Syndro | 1977 |
Intravenous clonidine in severe childhood hypertension.
Topics: Adolescent; Adult; Child; Child, Preschool; Clonidine; Female; Humans; Hypertension, Malignant; Infa | 1979 |
Withdrawal of antihypertensive therapy. Hypertensive crisis in renovascular hypertension.
Topics: Acute Disease; Aged; Blood Pressure; Clonidine; Diuretics; Female; Humans; Hypertension, Malignant; | 1977 |
Evaluation of intravenous clonidine in hypertensive emergencies.
Topics: Adult; Aged; Clonidine; Dose-Response Relationship, Drug; Emergencies; Female; Humans; Hypertension; | 1978 |
[Therapy of hypertensive crises].
Topics: Acute Disease; Adrenal Gland Neoplasms; Antihypertensive Agents; Clonidine; Diazoxide; Dihydralazine | 1977 |
Acute clonidine withdrawal syndrome following open-heart operation.
Topics: Cardiopulmonary Bypass; Clonidine; Delirium; Female; Humans; Hypertension, Malignant; Middle Aged; S | 1977 |
Symptoms of clonidine withdrawal after 17 days.
Topics: Clonidine; Female; Humans; Hypertension; Hypertension, Malignant; Middle Aged; Substance Withdrawal | 1976 |
[Hemolytic-uremic syndrome in a young woman following the use of ovulation inhibitors].
Topics: Adult; Blindness; Clonidine; Contraceptives, Oral; Contraceptives, Oral, Hormonal; Diazoxide; Female | 1975 |
Letter: Late toxicity of clonidine withdrawal.
Topics: Clonidine; Female; Humans; Hypertension; Hypertension, Malignant; Middle Aged; Substance Withdrawal | 1976 |
Hypertensive emergencies.
Topics: Antihypertensive Agents; Blood Pressure; Clonidine; Diazoxide; Emergencies; Humans; Hydralazine; Hyp | 1985 |
[Hypertensive emergencies].
Topics: Brain Edema; Clonidine; Diazoxide; Digitalis Glycosides; Diuretics; Drug Combinations; Emergencies; | 1974 |
[Medical treatment of severe or malignant arterial hypertension].
Topics: Antihypertensive Agents; Clonidine; Diet, Sodium-Restricted; Hemodynamics; Humans; Hypertension, Mal | 1972 |
Clonidine in the treatment of severe hypertension.
Topics: Adult; Anesthesia, General; Cerebrovascular Disorders; Clonidine; Coronary Disease; Depression; Huma | 1973 |