clonidine has been researched along with Low Back Ache in 16 studies
Clonidine: An imidazoline sympatholytic agent that stimulates ALPHA-2 ADRENERGIC RECEPTORS and central IMIDAZOLINE RECEPTORS. It is commonly used in the management of HYPERTENSION.
clonidine (amino form) : A clonidine that is 4,5-dihydro-1H-imidazol-2-amine in which one of the amino hydrogens is replaced by a 2,6-dichlorophenyl group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Adding baclofen, metaxalone, or tizanidine to ibuprofen does not appear to improve functioning or pain any more than placebo plus ibuprofen by 1 week after an ED visit for acute low back pain." | 9.30 | A Randomized, Placebo-Controlled Trial of Ibuprofen Plus Metaxalone, Tizanidine, or Baclofen for Acute Low Back Pain. ( Friedman, BW; Gallagher, EJ; Irizarry, E; Jones, MP; Pearlman, S; Shah, PD; Solorzano, C; Wollowitz, A; Zias, E, 2019) |
| "Tizanidine and aceclofenac individually have shown efficacy in the treatment of low back pain." | 9.14 | Aceclofenac-tizanidine in the treatment of acute low back pain: a double-blind, double-dummy, randomized, multicentric, comparative study against aceclofenac alone. ( Ambade, R; Bartakke, G; Chandanwale, AS; Chandurkar, N; Gupta, A; Pareek, A, 2009) |
| "Eperisone, an analgesic and centrally acting muscle relaxant has been in use for the treatment of low back pain (LBP)." | 8.93 | Clinical efficacy and safety of eperisone for low back pain: A systematic literature review. ( Ali Kareem, S; Bavage, S; Dhadde, SB; Durg, S, 2016) |
| "Tizanidine hydrochloride, an alpha(2)-adrenergic receptor agonist, is a widely used medication for the treatment of muscle spasticity." | 8.84 | Update on tizanidine for muscle spasticity and emerging indications. ( Garay, E; Malanga, G; Reiter, RD, 2008) |
| "The case of a 59-year-old healthy woman is described, who developed an extreme sinus bradycardia (30/min) with chest pain and acute right heart failure associated with gastrointestinal symptoms and elevation of the liver enzymes while simultaneously taking tizanidine (Sirdalud), diclofenac (Voltaren), and rofecoxib (Vioxx)." | 7.73 | [Extreme sinus bradycardia (30/min) with acute right heart failure under tizanidine (Sirdalud). Possible pharmacological interaction with rofecoxib (Vioxx)]. ( Bertoli, R; Caduff Janosa, P; Cerny, A; Kick, A; Moschovitis, G, 2005) |
| "Muscle spasm is an involuntary, painful contraction of muscles that interferes with the function and cause of muscular disorder." | 6.73 | Efficacy of thiocolchicoside in Indian patients suffering from low back pain associated with muscle spasm. ( Joshi, N; Soonawalla, DF, 2008) |
| "Adding baclofen, metaxalone, or tizanidine to ibuprofen does not appear to improve functioning or pain any more than placebo plus ibuprofen by 1 week after an ED visit for acute low back pain." | 5.30 | A Randomized, Placebo-Controlled Trial of Ibuprofen Plus Metaxalone, Tizanidine, or Baclofen for Acute Low Back Pain. ( Friedman, BW; Gallagher, EJ; Irizarry, E; Jones, MP; Pearlman, S; Shah, PD; Solorzano, C; Wollowitz, A; Zias, E, 2019) |
| "Tizanidine and aceclofenac individually have shown efficacy in the treatment of low back pain." | 5.14 | Aceclofenac-tizanidine in the treatment of acute low back pain: a double-blind, double-dummy, randomized, multicentric, comparative study against aceclofenac alone. ( Ambade, R; Bartakke, G; Chandanwale, AS; Chandurkar, N; Gupta, A; Pareek, A, 2009) |
| "Eperisone, an analgesic and centrally acting muscle relaxant has been in use for the treatment of low back pain (LBP)." | 4.93 | Clinical efficacy and safety of eperisone for low back pain: A systematic literature review. ( Ali Kareem, S; Bavage, S; Dhadde, SB; Durg, S, 2016) |
| "Tizanidine hydrochloride, an alpha(2)-adrenergic receptor agonist, is a widely used medication for the treatment of muscle spasticity." | 4.84 | Update on tizanidine for muscle spasticity and emerging indications. ( Garay, E; Malanga, G; Reiter, RD, 2008) |
| "Intrathecal Baclofen and Clonidine may be used as alternatives to provide spinally mediated antinociception when intraspinal opioid fails due to pharmacological side effects such as persistent edema." | 3.76 | Recurrent cellulitis associated with long-term intrathecal opioid infusion therapy: a case report and review of the literature. ( Chiravuri, S; Couch, JP; Liu, H; Ruan, X; Wang, F, 2010) |
| "The case of a 59-year-old healthy woman is described, who developed an extreme sinus bradycardia (30/min) with chest pain and acute right heart failure associated with gastrointestinal symptoms and elevation of the liver enzymes while simultaneously taking tizanidine (Sirdalud), diclofenac (Voltaren), and rofecoxib (Vioxx)." | 3.73 | [Extreme sinus bradycardia (30/min) with acute right heart failure under tizanidine (Sirdalud). Possible pharmacological interaction with rofecoxib (Vioxx)]. ( Bertoli, R; Caduff Janosa, P; Cerny, A; Kick, A; Moschovitis, G, 2005) |
| "To determine the clinical usefulness of the long-term intrathecal administration of midazolam and clonidine in patients with refractory neurogenic and musculoskeletal pain." | 3.69 | Long-term intrathecal administration of midazolam and clonidine. ( Borg, PA; Krijnen, HJ, 1996) |
| "To compare extracorporeal shock wave therapy combined with oral medication and an exercise program vs sham treatment with medication and exercise for the treatment of chronic low back pain (CLBP)." | 3.01 | Extracorporeal Shock Wave Therapy Combined With Oral Medication and Exercise for Chronic Low Back Pain: A Randomized Controlled Trial. ( Khosrawi, S; Ramezani, M; Taheri, P, 2021) |
| "Muscle spasm is an involuntary, painful contraction of muscles that interferes with the function and cause of muscular disorder." | 2.73 | Efficacy of thiocolchicoside in Indian patients suffering from low back pain associated with muscle spasm. ( Joshi, N; Soonawalla, DF, 2008) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (6.25) | 18.2507 |
| 2000's | 8 (50.00) | 29.6817 |
| 2010's | 6 (37.50) | 24.3611 |
| 2020's | 1 (6.25) | 2.80 |
| Authors | Studies |
|---|---|
| Luther, JM | 1 |
| Dominiczak, AF | 1 |
| Jennings, GLR | 1 |
| VanDevender, FK | 1 |
| Carey, RM | 1 |
| Peixoto, AJ | 1 |
| Chung, CP | 1 |
| Oates, JA | 1 |
| Taheri, P | 1 |
| Khosrawi, S | 1 |
| Ramezani, M | 1 |
| Friedman, BW | 1 |
| Irizarry, E | 1 |
| Solorzano, C | 1 |
| Zias, E | 1 |
| Pearlman, S | 1 |
| Wollowitz, A | 1 |
| Jones, MP | 1 |
| Shah, PD | 1 |
| Gallagher, EJ | 1 |
| Holroyd, KB | 1 |
| Rittenberg, A | 1 |
| Pahwa, A | 1 |
| Bavage, S | 1 |
| Durg, S | 1 |
| Ali Kareem, S | 1 |
| Dhadde, SB | 1 |
| Malanga, G | 1 |
| Reiter, RD | 1 |
| Garay, E | 1 |
| Soonawalla, DF | 1 |
| Joshi, N | 1 |
| Pareek, A | 1 |
| Chandurkar, N | 1 |
| Chandanwale, AS | 1 |
| Ambade, R | 1 |
| Gupta, A | 1 |
| Bartakke, G | 1 |
| Ruan, X | 1 |
| Liu, H | 1 |
| Couch, JP | 1 |
| Wang, F | 1 |
| Chiravuri, S | 1 |
| Rossi, M | 1 |
| Ianigro, G | 1 |
| Liberatoscioli, G | 1 |
| Di Castelnuovo, A | 1 |
| Grimani, V | 1 |
| Garofano, A | 1 |
| Camposarcone, N | 1 |
| Nardi, LF | 1 |
| Shargorodsky, M | 1 |
| Zimlichman, R | 1 |
| Moufarrege, G | 1 |
| Frank, E | 1 |
| Carstens, DD | 1 |
| Kick, A | 1 |
| Bertoli, R | 1 |
| Moschovitis, G | 1 |
| Caduff Janosa, P | 1 |
| Cerny, A | 1 |
| Ketenci, A | 1 |
| Ozcan, E | 1 |
| Karamursel, S | 1 |
| Borg, PA | 1 |
| Krijnen, HJ | 1 |
| Richardson, J | 1 |
| McGurgan, P | 1 |
| Cheema, S | 1 |
| Prasad, R | 1 |
| Gupta, S | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Ibuprofen Plus Metaxolone, Tizanidine, or Baclofen for Low Back Pain: A Randomized Trial[NCT03068897] | Phase 4 | 320 participants (Actual) | Interventional | 2017-05-03 | Completed | ||
| The Effects of EXOPULSE Mollii Suit on Spasticity and Muscular Oxygenation in Patients With Multiple Sclerosis.[NCT05912595] | 36 participants (Anticipated) | Interventional | 2023-05-18 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
"The Roland Morris Disability Questionnaire (RMDQ) is a 24 item instrument that evaluates the impact of low back pain on one's daily life. It is most sensitive for patients with mild to moderate disability due to acute, sub-acute or chronic low back pain. Each question can be answered as either a yes or no. The score ranges from 0 to 24 where a higher score reflects greater impairment and, therefore, worsening in the quality of life. The change in RMDQ is obtained by subtracting the RMDQ score at one week after discharge from the baseline score." (NCT03068897)
Timeframe: Baseline and 7 days
| Intervention | units on a scale (Mean) |
|---|---|
| Metaxalone | 10.1 |
| Tizanidine | 11.2 |
| Baclofen | 10.6 |
| Placebo | 11.1 |
Disability will be assessed with the Roland-Morris Disability Questionnaire (RMDQ) where patients are asked to tick a box if they agree with 24 statements regarding their ability to perform certain activities (dressing, housework, walking). If the don't agree with the statement (able to perform those activities) they need to leave the tick-box blank or unchecked. Every agreement (tick) counts as a point and an absolute value is formed (min: 0, max: 24). The higher the value the higher the disability level. (NCT03068897)
Timeframe: 7 days
| Intervention | units on a scale (Median) |
|---|---|
| Metaxalone | 5 |
| Tizanidine | 3 |
| Baclofen | 6 |
| Placebo | 3 |
Change is assessed by verbal numerical scale of which 0 represents no pain and 10 represents the worst pain imaginable between the baseline ED visit and the one week follow-up (baseline - 1 week ). The baseline questions will refer to the time period immediately prior to ED presentation (Before you came to the ER today, were you able to…..) (NCT03068897)
Timeframe: Baseline and 7 days
| Intervention | Participants (Count of Participants) |
|---|---|
| Metaxalone | 28 |
| Tizanidine | 25 |
| Baclofen | 26 |
| Placebo | 22 |
Patients will be asked what medications they have used for low back pain (NCT03068897)
Timeframe: 7 days
| Intervention | Participants (Count of Participants) |
|---|---|
| Metaxalone | 49 |
| Tizanidine | 48 |
| Baclofen | 49 |
| Placebo | 46 |
2 reviews available for clonidine and Low Back Ache
| Article | Year |
|---|---|
Clinical efficacy and safety of eperisone for low back pain: A systematic literature review.
Topics: Chronic Pain; Clonidine; Humans; Low Back Pain; Pain Measurement; Propiophenones; Treatment Outcome | 2016 |
Update on tizanidine for muscle spasticity and emerging indications.
Topics: Adrenergic alpha-2 Receptor Agonists; Clonidine; Dose-Response Relationship, Drug; Humans; Low Back | 2008 |
6 trials available for clonidine and Low Back Ache
| Article | Year |
|---|---|
Extracorporeal Shock Wave Therapy Combined With Oral Medication and Exercise for Chronic Low Back Pain: A Randomized Controlled Trial.
Topics: Adult; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Clonidine; Combined Modality Therapy; Di | 2021 |
A Randomized, Placebo-Controlled Trial of Ibuprofen Plus Metaxalone, Tizanidine, or Baclofen for Acute Low Back Pain.
Topics: Acute Pain; Adult; Analgesics, Non-Narcotic; Baclofen; Clonidine; Double-Blind Method; Drug Therapy, | 2019 |
Efficacy of thiocolchicoside in Indian patients suffering from low back pain associated with muscle spasm.
Topics: Acute Disease; Administration, Oral; Adult; Analgesics; Clonidine; Colchicine; Female; Humans; India | 2008 |
Aceclofenac-tizanidine in the treatment of acute low back pain: a double-blind, double-dummy, randomized, multicentric, comparative study against aceclofenac alone.
Topics: Activities of Daily Living; Acute Disease; Adolescent; Adult; Aged; Analgesics; Anti-Inflammatory Ag | 2009 |
Eperisone versus tizanidine for treatment of chronic low back pain.
Topics: Analysis of Variance; Chronic Pain; Clonidine; Drug Therapy, Combination; Female; Humans; Italy; Low | 2012 |
Assessment of efficacy and psychomotor performances of thiocolchicoside and tizanidine in patients with acute low back pain.
Topics: Acute Disease; Adrenergic alpha-Agonists; Adult; Clonidine; Colchicine; Double-Blind Method; Female; | 2005 |
8 other studies available for clonidine and Low Back Ache
| Article | Year |
|---|---|
Paroxysmal Hypertension Associated With Presyncope.
Topics: Clonidine; Female; Humans; Hypertension; Low Back Pain; Middle Aged; Muscle Relaxants, Central; Sync | 2019 |
Misanalysis of Urinalysis: A Teachable Moment.
Topics: Analgesics, Opioid; Anti-Bacterial Agents; Cefpodoxime; Ceftizoxime; Clonidine; Diagnostic Errors; E | 2016 |
Recurrent cellulitis associated with long-term intrathecal opioid infusion therapy: a case report and review of the literature.
Topics: Analgesics, Opioid; Baclofen; Cellulitis; Clonidine; Edema; Female; GABA Agonists; Humans; Hydromorp | 2010 |
Pheochromocytoma: a disease with many faces.
Topics: Adrenal Gland Neoplasms; Catecholamines; Chromatography, High Pressure Liquid; Clonidine; Diagnosis, | 2002 |
Eosinophilic exudative pleural effusion after initiation of tizanidine treatment: a case report.
Topics: Adult; Analgesics; Chronic Disease; Clonidine; Eosinophilia; Humans; Low Back Pain; Male; Pleural Ef | 2003 |
[Extreme sinus bradycardia (30/min) with acute right heart failure under tizanidine (Sirdalud). Possible pharmacological interaction with rofecoxib (Vioxx)].
Topics: Acute Disease; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Bradycardia; Clonidine; Cyclooxy | 2005 |
Long-term intrathecal administration of midazolam and clonidine.
Topics: Activities of Daily Living; Adolescent; Adult; Analgesics, Non-Narcotic; Clonidine; Female; Humans; | 1996 |
Spinal endoscopy in chronic low back pain with radiculopathy. A prospective case series.
Topics: Ambulatory Surgical Procedures; Analgesics; Analysis of Variance; Anesthetics, Local; Anti-Inflammat | 2001 |