clonidine has been researched along with Long QT Syndrome in 6 studies
Clonidine: An imidazoline sympatholytic agent that stimulates ALPHA-2 ADRENERGIC RECEPTORS and central IMIDAZOLINE RECEPTORS. It is commonly used in the management of HYPERTENSION.
clonidine (amino form) : A clonidine that is 4,5-dihydro-1H-imidazol-2-amine in which one of the amino hydrogens is replaced by a 2,6-dichlorophenyl group.
Long QT Syndrome: A condition that is characterized by episodes of fainting (SYNCOPE) and varying degree of ventricular arrhythmia as indicated by the prolonged QT interval. The inherited forms are caused by mutation of genes encoding cardiac ion channel proteins. The two major forms are ROMANO-WARD SYNDROME and JERVELL-LANGE NIELSEN SYNDROME.
| Excerpt | Relevance | Reference |
|---|---|---|
| " To test this hypothesis, the effects of 2 clinically available α-2 AR agonists (dexmedetomidine and clonidine) on the occurrence of VTs were assessed in a methoxamine-sensitized rabbit model of acquired long QT syndrome (Study 1: n=45)." | 7.78 | Dexmedetomidine and clonidine inhibit ventricular tachyarrhythmias in a rabbit model of acquired long QT syndrome. ( Ajiki, K; Hayami, N; Kanamori, K; Kunishima, T; Mikamo, T; Murakawa, Y; Sugiura, A; Tsutsui, K; Watanabe, H; Yamagishi, N; Yamagishi, S, 2012) |
| "There were more incidents of bradycardia in subjects treated with clonidine compared with those not treated with clonidine (17." | 5.13 | Clonidine for attention-deficit/hyperactivity disorder: II. ECG changes and adverse events analysis. ( Bukstein, OG; Daviss, WB; Harris, P; McDERMOTT, MP; Palumbo, D; Patel, NC; Pelham, WE; Robb, AS; Sallee, FR, 2008) |
| " Several studies have shown that panic disorder is associated with an increased sensitivity to yohimbine and a blunted growth hormone response to clonidine, which are alpha-2 adrenoceptor antagonist and agonist, respectively." | 5.10 | Heart rate and QT interval variability: abnormal alpha-2 adrenergic function in patients with panic disorder. ( Tancer, M; Uhde, T; Yeragani, VK, 2003) |
| " To test this hypothesis, the effects of 2 clinically available α-2 AR agonists (dexmedetomidine and clonidine) on the occurrence of VTs were assessed in a methoxamine-sensitized rabbit model of acquired long QT syndrome (Study 1: n=45)." | 3.78 | Dexmedetomidine and clonidine inhibit ventricular tachyarrhythmias in a rabbit model of acquired long QT syndrome. ( Ajiki, K; Hayami, N; Kanamori, K; Kunishima, T; Mikamo, T; Murakawa, Y; Sugiura, A; Tsutsui, K; Watanabe, H; Yamagishi, N; Yamagishi, S, 2012) |
| " We aimed to quantify co-administration of MQAB with interacting drugs and associated adverse drug reactions." | 1.43 | Drug safety of macrolide and quinolone antibiotics in a tertiary care hospital: administration of interacting co-medication and QT prolongation. ( Corti, N; Hoppe, L; Kovari, H; Maechler, S; Niedrig, D; Russmann, S, 2016) |
| "Tizanidine (Zanaflex) is a centrally acting imidazoline muscle relaxant that is structurally similar to clonidine (α(2)-adrenergic agonist) but not to other myorelaxants such as baclofen or benzodiazepines." | 1.38 | Tizanidine (Zanaflex): a muscle relaxant that may prolong the QT interval by blocking IKr. ( Drolet, B; Kaddar, N; Patoine, D; Pilote, S; Simard, C; Vigneault, P, 2012) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (50.00) | 29.6817 |
| 2010's | 3 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Niedrig, D | 1 |
| Maechler, S | 1 |
| Hoppe, L | 1 |
| Corti, N | 1 |
| Kovari, H | 1 |
| Russmann, S | 1 |
| Kaddar, N | 1 |
| Vigneault, P | 1 |
| Pilote, S | 1 |
| Patoine, D | 1 |
| Simard, C | 1 |
| Drolet, B | 1 |
| Tsutsui, K | 1 |
| Hayami, N | 1 |
| Kunishima, T | 1 |
| Sugiura, A | 1 |
| Mikamo, T | 1 |
| Kanamori, K | 1 |
| Yamagishi, N | 1 |
| Yamagishi, S | 1 |
| Watanabe, H | 1 |
| Ajiki, K | 1 |
| Murakawa, Y | 1 |
| Yeragani, VK | 1 |
| Tancer, M | 1 |
| Uhde, T | 1 |
| Schmittner, J | 1 |
| Schroeder, JR | 1 |
| Epstein, DH | 1 |
| Preston, KL | 1 |
| Daviss, WB | 1 |
| Patel, NC | 1 |
| Robb, AS | 1 |
| McDERMOTT, MP | 1 |
| Bukstein, OG | 1 |
| Pelham, WE | 1 |
| Palumbo, D | 1 |
| Harris, P | 1 |
| Sallee, FR | 1 |
2 trials available for clonidine and Long QT Syndrome
| Article | Year |
|---|---|
Heart rate and QT interval variability: abnormal alpha-2 adrenergic function in patients with panic disorder.
Topics: Adrenergic alpha-Agonists; Adult; Clonidine; Double-Blind Method; Female; Heart Rate; Humans; Long Q | 2003 |
Clonidine for attention-deficit/hyperactivity disorder: II. ECG changes and adverse events analysis.
Topics: Adrenergic alpha-Agonists; Attention Deficit Disorder with Hyperactivity; Bradycardia; Central Nervo | 2008 |
4 other studies available for clonidine and Long QT Syndrome
| Article | Year |
|---|---|
Drug safety of macrolide and quinolone antibiotics in a tertiary care hospital: administration of interacting co-medication and QT prolongation.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anti-Bacterial Agents; Atorvastatin; Clonidine; Drug Int | 2016 |
Tizanidine (Zanaflex): a muscle relaxant that may prolong the QT interval by blocking IKr.
Topics: Animals; CHO Cells; Clonidine; Cricetinae; Cricetulus; Dose-Response Relationship, Drug; Guinea Pigs | 2012 |
Dexmedetomidine and clonidine inhibit ventricular tachyarrhythmias in a rabbit model of acquired long QT syndrome.
Topics: Adrenergic alpha-1 Receptor Agonists; Adrenergic alpha-2 Receptor Agonists; Animals; Anti-Arrhythmia | 2012 |
QT interval increased after single dose of lofexidine.
Topics: Adult; Clonidine; Female; Humans; Long QT Syndrome; Methadone; Narcotic Antagonists | 2004 |