clonidine has been researched along with Liver Cirrhosis in 12 studies
Clonidine: An imidazoline sympatholytic agent that stimulates ALPHA-2 ADRENERGIC RECEPTORS and central IMIDAZOLINE RECEPTORS. It is commonly used in the management of HYPERTENSION.
clonidine (amino form) : A clonidine that is 4,5-dihydro-1H-imidazol-2-amine in which one of the amino hydrogens is replaced by a 2,6-dichlorophenyl group.
Liver Cirrhosis: Liver disease in which the normal microcirculation, the gross vascular anatomy, and the hepatic architecture have been variably destroyed and altered with fibrous septa surrounding regenerated or regenerating parenchymal nodules.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Sixty cirrhotic patients with refractory or recurrent ascites were prospectively studied after long-term administration of clonidine (n=15) or midodrine (n=15), or both (n=15) plus standard medical therapy (SMT), or SMT alone (n=15), in a randomized controlled trial at a tertiary center." | 9.17 | Midodrine and clonidine in patients with cirrhosis and refractory or recurrent ascites: a randomized pilot study. ( Bhalla, A; Ghai, A; Sharma, N; Singh, A; Singh, B; Singh, V; Vijayvergiya, R, 2013) |
| "To study the usefulness of the combination of clonidine--spironolactone in refractory ascites." | 9.11 | Comparative pilot study of repeated large volume paracentesis vs the combination on clonidine-spironolactone in the treatment of cirrhosis-associated refractory ascites. ( Codden, T; Henry, JP; Legros, F; Lenaerts, A; Ligny, G, 2005) |
| "The aim of the present study was to examine the short- and long-term effects of the alpha 2-agonist clonidine on sympathetic overactivity, systemic, splanchnic, and renal circulation changes, and abnormal renal sodium excretion in cirrhotic patients with ascites." | 9.07 | Long-term sympathetic and hemodynamic responses to clonidine in patients with cirrhosis and ascites. ( Bacq, Y; Braillon, A; Frohly, P; Gaudin, C; Hadengue, A; Lebrec, D; Moreau, R; Roulot, D, 1992) |
| "Sixty cirrhotic patients with refractory or recurrent ascites were prospectively studied after long-term administration of clonidine (n=15) or midodrine (n=15), or both (n=15) plus standard medical therapy (SMT), or SMT alone (n=15), in a randomized controlled trial at a tertiary center." | 5.17 | Midodrine and clonidine in patients with cirrhosis and refractory or recurrent ascites: a randomized pilot study. ( Bhalla, A; Ghai, A; Sharma, N; Singh, A; Singh, B; Singh, V; Vijayvergiya, R, 2013) |
| "The effects of the addition of clonidine to diuretics on the mobilization of ascites in the short term (diuretic response and requirement of diuretics) and the long term (readmissions for tense ascites and requirement of diuretics) were examined in patients with cirrhosis and with increased sympathetic nervous system (SNS) activity." | 5.12 | Effects of clonidine on diuretic response in ascitic patients with cirrhosis and activation of sympathetic nervous system. ( Codden, T; Henry, JP; Lenaerts, A; Ligny, G; Meunier, JC, 2006) |
| "To study the usefulness of the combination of clonidine--spironolactone in refractory ascites." | 5.11 | Comparative pilot study of repeated large volume paracentesis vs the combination on clonidine-spironolactone in the treatment of cirrhosis-associated refractory ascites. ( Codden, T; Henry, JP; Legros, F; Lenaerts, A; Ligny, G, 2005) |
| "The absence of any effects on the parameters of portal haemodynamics would appear to deny clonidine any significant role in preventing first bleeding resulting from the rupture of oesophageal varices." | 5.08 | Effects of propranolol compared with clonidine on portal haemodynamics: a double-blind cross-over study using duplex-Doppler ultrasonography. ( Cioni, G; Cristani, A; D'Alimonte, P; Romagnoli, R; Tincani, E; Turrini, F; Ventura, E, 1995) |
| "The aim of the present study was to examine the short- and long-term effects of the alpha 2-agonist clonidine on sympathetic overactivity, systemic, splanchnic, and renal circulation changes, and abnormal renal sodium excretion in cirrhotic patients with ascites." | 5.07 | Long-term sympathetic and hemodynamic responses to clonidine in patients with cirrhosis and ascites. ( Bacq, Y; Braillon, A; Frohly, P; Gaudin, C; Hadengue, A; Lebrec, D; Moreau, R; Roulot, D, 1992) |
| "Clonidine is an α(2)-adrenoceptor agonist which, by coupling with G-protein, has been proposed as an alternative treatment for refractory ascites of patients with cirrhosis for several years." | 2.75 | Association of the G-protein and α2-adrenergic receptor gene and plasma norepinephrine level with clonidine improvement of the effects of diuretics in patients with cirrhosis with refractory ascites: a randomised clinical trial. ( Chu, CJ; Hou, MC; Jap, JS; Lee, FY; Lee, SD; Lee, WP; Lin, HC; Lin, MW; Yang, YY, 2010) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (25.00) | 18.2507 |
| 2000's | 6 (50.00) | 29.6817 |
| 2010's | 3 (25.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Singh, V | 1 |
| Singh, A | 1 |
| Singh, B | 1 |
| Vijayvergiya, R | 1 |
| Sharma, N | 1 |
| Ghai, A | 1 |
| Bhalla, A | 1 |
| Yang, YY | 1 |
| Lin, HC | 1 |
| Lee, WP | 1 |
| Chu, CJ | 1 |
| Lin, MW | 1 |
| Lee, FY | 1 |
| Hou, MC | 1 |
| Jap, JS | 1 |
| Lee, SD | 1 |
| Singhal, S | 1 |
| Baikati, KK | 1 |
| Jabbour, II | 1 |
| Anand, S | 1 |
| Bandhyopadhyay, B | 1 |
| Reddy, DV | 1 |
| Singh, SK | 1 |
| Lenaerts, A | 2 |
| Codden, T | 2 |
| Henry, JP | 2 |
| Legros, F | 1 |
| Ligny, G | 2 |
| Shimamura, K | 1 |
| Toba, M | 1 |
| Kimura, S | 1 |
| Ohashi, A | 1 |
| Kitamura, K | 1 |
| Meunier, JC | 1 |
| Rai, RR | 1 |
| Jain, P | 1 |
| Momo, K | 1 |
| Homma, M | 1 |
| Abei, M | 1 |
| Hyodo, I | 1 |
| Kohda, Y | 1 |
| Tincani, E | 1 |
| Cioni, G | 1 |
| D'Alimonte, P | 1 |
| Cristani, A | 1 |
| Turrini, F | 1 |
| Romagnoli, R | 1 |
| Ventura, E | 1 |
| Moreau, R | 2 |
| Roulot, D | 1 |
| Gaudin, C | 1 |
| Bacq, Y | 1 |
| Braillon, A | 1 |
| Hadengue, A | 1 |
| Frohly, P | 1 |
| Lebrec, D | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Peritoneal Dialysis Catheters for the Treatment of Refractory Ascites Management: A Randomized Un-Blinded Pilot Study[NCT02975726] | 2 participants (Actual) | Interventional | 2017-01-31 | Completed | |||
| The Effects of Clonidine on the Diuretic Response in Cirrhotic Patients With Ascites and Activation of Sympathetic Nervous System: a Randomized Double-Blind Placebo Controlled Study.[NCT00356226] | 64 participants | Interventional | 2000-10-31 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for clonidine and Liver Cirrhosis
| Article | Year |
|---|---|
Management of refractory ascites.
Topics: Albumins; Ascites; Clonidine; Diuretics; Humans; Liver Cirrhosis; Liver Transplantation; Paracentesi | 2012 |
[Short and long-term effects of clonidine on sympathetic activity, hemodynamics and renal metabolism of water and sodium in patients with liver cirrhosis].
Topics: Clonidine; Diuresis; Glomerular Filtration Rate; Hemodynamics; Humans; Liver Cirrhosis; Natriuresis; | 1992 |
6 trials available for clonidine and Liver Cirrhosis
| Article | Year |
|---|---|
Midodrine and clonidine in patients with cirrhosis and refractory or recurrent ascites: a randomized pilot study.
Topics: Adrenergic alpha-1 Receptor Agonists; Adrenergic alpha-2 Receptor Agonists; Adult; Aged; Ascites; Cl | 2013 |
Association of the G-protein and α2-adrenergic receptor gene and plasma norepinephrine level with clonidine improvement of the effects of diuretics in patients with cirrhosis with refractory ascites: a randomised clinical trial.
Topics: Adolescent; Adrenergic alpha-Agonists; Adult; Aged; Clonidine; Diuretics; Drug Administration Schedu | 2010 |
Comparative pilot study of repeated large volume paracentesis vs the combination on clonidine-spironolactone in the treatment of cirrhosis-associated refractory ascites.
Topics: Adrenergic alpha-Agonists; Ascites; Clonidine; Diuretics; Drug Resistance; Drug Therapy, Combination | 2005 |
Effects of clonidine on diuretic response in ascitic patients with cirrhosis and activation of sympathetic nervous system.
Topics: Angiotensins; Ascites; Clonidine; Diuretics; Drug Therapy, Combination; Female; Furosemide; Heart Ra | 2006 |
Effects of propranolol compared with clonidine on portal haemodynamics: a double-blind cross-over study using duplex-Doppler ultrasonography.
Topics: Administration, Oral; Adrenergic alpha-Agonists; Blood Flow Velocity; Blood Pressure; Clonidine; Cro | 1995 |
Long-term sympathetic and hemodynamic responses to clonidine in patients with cirrhosis and ascites.
Topics: Ascites; Clonidine; Female; Hemodynamics; Humans; Liver Cirrhosis; Male; Middle Aged; Norepinephrine | 1992 |
4 other studies available for clonidine and Liver Cirrhosis
| Article | Year |
|---|---|
Basal and stimulated growth hormone levels in children with cirrhotic disorders.
Topics: Bromocriptine; Case-Control Studies; Child; Child, Preschool; Clonidine; Female; Hormone Antagonists | 2004 |
Clonidine induced endothelium-dependent tonic contraction in circular muscle of the rat hepatic portal vein.
Topics: Adrenergic alpha-Agonists; Animals; Clonidine; Diclofenac; Endothelium, Vascular; Humans; Hypertensi | 2006 |
Combination of clonidine and diuretic in cirrhotic ascites with activated sympathetic nervous system: Would it be a magical bullet?
Topics: Ascites; Clonidine; Diuretics; Humans; Liver Cirrhosis; Spironolactone; Sympathetic Nervous System; | 2008 |
Tizanidine-induced hypotension in patients with liver cirrhosis.
Topics: Aged; Clonidine; Female; Humans; Hypotension; Liver Cirrhosis; Male; Middle Aged; Parasympatholytics | 2008 |