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clonidine and Intraocular Pressure

clonidine has been researched along with Intraocular Pressure in 225 studies

Clonidine: An imidazoline sympatholytic agent that stimulates ALPHA-2 ADRENERGIC RECEPTORS and central IMIDAZOLINE RECEPTORS. It is commonly used in the management of HYPERTENSION.
clonidine (amino form) : A clonidine that is 4,5-dihydro-1H-imidazol-2-amine in which one of the amino hydrogens is replaced by a 2,6-dichlorophenyl group.

Intraocular Pressure: The pressure of the fluids in the eye.

Research Excerpts

ExcerptRelevanceReference
"5% apraclonidine on Intraocular pressure (IOP) in horses and compare the effects of timolol maleate 0."9.51Effect of Topically Applied 0.5% Apraclonidine Versus 0.5% Timolol Maleate on Intraocular Pressure of Healthy Horses. ( Asghari, A; Ozmaie, S; Rajaei, SM; Ziadi, A, 2022)
"PRéCIS:: Adjuvant diclofenac and apraclonidine eye drop given in conjunction with selective laser trabeculoplasty (SLT) do not significantly impact medium-term intraocular pressure (IOP) reduction compared with placebo, but apraclonidine can be used to blunt immediate postlaser pressure spikes."9.34Effect of Apraclonidine and Diclofenac on Early Changes in Intraocular Pressure After Selective Laser Trabeculoplasty. ( Bergo, C; Halvorsen, H; Krohn, J; Thrane, AS; Thrane, VR, 2020)
"To evaluate the efficacy of preoperative oral clonidine (5 g/kg) in preventing ocular hypertension in the early period after cataract surgery with posterior chamber intraocular lens implantation under general anaesthesia."9.16Effect of oral clonidine on acute intraocular pressure rise after cataract extraction under general anaesthesia. ( Boroojeny, SB; Fard, MM, 2012)
"To determine the efficacy and safety of oral clonidine in decreasing the prevalence and intensity of postoperative intraocular pressure (IOP) rise in those undergoing phacoemulsification."9.15Effect of oral clonidine on acute intraocular pressure rise after phacoemulsification: a prospective double-blind, randomized, clinical trial. ( Boroojeny, SB; Fard, MM; Ghaffarpasand, F; Hourang, MH; Zakeri, H; Zeraatian, S, 2011)
"Clonidine significantly decreased mean arterial pressure (MAP) and intraocular pressure (IOP)."9.12Intravenous administration of clonidine reduces intraocular pressure and alters ocular blood flow. ( Fuchsjager-Mayrl, G; Garhofer, G; Luksch, A; Reitsamer, HA; Resch, H; Schmetterer, L; Weigert, G, 2007)
"Clonidine and brimonidine, two alpha-2 agonists, have been shown to reduce intraocular pressure (IOP) in patients with glaucoma."9.12Effects of topical clonidine versus brimonidine on choroidal blood flow and intraocular pressure during squatting. ( Fuchsjäger-Mayrl, G; Garhofer, G; Resch, H; Schmetterer, L; Weigert, G, 2007)
"The aim was to determine if the intravenous administration of sufentanil or clonidine before the induction of anaesthesia could obtund the increase of intraocular pressure associated with rapid-sequence induction."9.10Sufentanil or clonidine for blunting the increase in intraocular pressure during rapid-sequence induction. ( Argiriadou, H; Georgiou, M; Kaprini, E; Katsikis, G; Papagiannopoulou, P; Parlapani, A, 2002)
"To evaluate the effectiveness of prophylactic topical apraclonidine 1% in preventing an intraocular pressure (IOP) rise in the early period after uneventful phacoemulsification with intraocular lens (IOL) implantation."9.10Preventing intraocular pressure increase after phacoemulsification and the role of perioperative apraclonidine. ( Desai, SP; Kasetti, SR; Sivakumar, S; Sunderraj, P, 2002)
"The authors compared the efficacy of apraclonidine 1% versus pilocarpine 4% prophylaxis of post-argon laser trabeculoplasty (ALT) intraocular pressure (IOP) spike."9.09Efficacy of apraclonidine 1% versus pilocarpine 4% for prophylaxis of intraocular pressure spike after argon laser trabeculoplasty. ( Birt, CM; Chung, HS; Glover, BK; Hughes, BA; Juzych, MS; Kim, C; Ren, J; Shin, DH, 1999)
"2% can control intraocular pressure (IOP) spikes as well as apraclonidine 1."9.09Control of intraocular pressure elevations after argon laser trabeculoplasty: comparison of brimonidine 0.2% to apraclonidine 1.0%. ( Barnes, SD; Campagna, JA; Dirks, MS; Doe, EA, 1999)
"Topical apraclonidine hydrochloride 1% is effective for controlling the intraocular pressure (IOP) rise following argon laser trabeculoplasty (ALT)."9.08Apraclonidine 0.5% versus 1% for controlling intraocular pressure elevation after argon laser trabeculoplasty. ( Allingham, RR; Assalian, AA; Shields, MB; Threlkeld, AB, 1996)
"0% apraclonidine in preventing laser-induced intraocular pressure (IOP) elevation after trabeculoplasty, neodymium: YAG (Nd: YAG) iridotomy, and capsulotomy."9.08Apraclonidine and anterior segment laser surgery. Comparison of 0.5% versus 1.0% apraclonidine for prevention of postoperative intraocular pressure rise. ( Gieser, DK; Grewal, RK; Karalekas, DP; Krupin, T; McDaniel, DL; Rosenberg, LF; Ruderman, J; Siegfried, C; Williams, R, 1995)
"To measure the effect of 1% apraclonidine hydrochloride eyedrops on intraocular pressure (IOP) after cataract surgery."9.08The effect of 1% apraclonidine on intraocular pressure after cataract surgery. ( Renzenbrink-Bubberman, AC; Sterk, CC; van Best, JA, 1998)
"To investigate if apraclonidine can effectively prevent the acute increase of intraocular pressure (IOP) in brown eyes with Nd:YAG laser iridectomy."9.08[Apraclonidine prevents the acute increase of intraocular pressure in brown eyes with Nd:YAG laser iridectomy]. ( Liu, X; Mao, J; Zhao, J, 1998)
"Apraclonidine effectively decreased large IOP elevations in glaucomatous eyes undergoing trabeculectomy combined with extracapsular cataract surgery."9.07Effect of topical apraclonidine on the frequency of intraocular pressure elevations after combined extracapsular cataract extraction and trabeculectomy. ( Robin, AL, 1993)
"To evaluate the effect of topical apraclonidine on early postoperative intraocular pressure and blood-aqueous barrier permeability, we conducted a double-masked clinical trial in which 37 patients undergoing uncomplicated phacoemulsification and posterior chamber intraocular lens implantation were randomly assigned to treatment with 1% apraclonidine or its vehicle."9.07Effects of apraclonidine on intraocular pressure and blood-aqueous barrier permeability after phacoemulsification and intraocular lens implantation. ( Araie, M; Ishi, K, 1993)
"The objective of the study was to assess the effects of premedication with clonidine on intraocular pressure (IOP) after the administration of succinylcholine."9.07Oral clonidine premedication prevents the rise in intraocular pressure following succinylcholine administration. ( Böhrer, H; Martin, E; Polarz, H; Völcker, HE; Wolfrum, J, 1993)
"Seventeen patients with glaucoma were given bilaterally a single drop of Isoglaucon (Clonidine hydrochloride) of various volume (15 microliters and 40 microliters) and various concentrations of the drug (0."9.07[Various clonidine drops in treatment of glaucoma]. ( Brozyna-Zyłka, B; Otrzonsek, D; Sobieraj, A; Szymański, A, 1992)
"We evaluated the prophylactic effect of 1% apraclonidine HCl in controlling the increase in intraocular pressure after Nd:YAG posterior capsulotomy in a large, multicenter double-masked clinical trial."9.07Prophylactic use of apraclonidine for intraocular pressure increase after Nd:YAG capsulotomies. ( Brint, SF; Burk, LL; deFaller, JM; McCarty, GR; Olander, KW; Silverstone, DE; Taylor, RB, 1992)
"We performed a prospective study that evaluated whether pretreatment with topical flurbiprofen alters the intraocular pressure (IOP) lowering effects of either topical 1% apraclonidine hydrochloride or 0."9.07Effects of topical flurbiprofen on the intraocular pressure lowering effects of apraclonidine and timolol. ( Arkin, LM; Cummings, HL; Robin, AL; Sulewski, ME, 1991)
"A randomized, prospective, double-masked study was undertaken to determine the risk of postcycloplegic intraocular pressure spikes in patients with open-angle glaucoma and to evaluate apraclonidine prophylaxis in minimizing these spikes."9.07Apraclonidine prophylaxis for postcycloplegic intraocular pressure spikes. ( Baerveldt, G; Heuer, DK; Hill, RA; Lee, M; Martone, JF; Minckler, DS, 1991)
"We studied the ability of topical clonidine, an alpha-agonist, to suppress the acute rise in intraocular pressure (IOP) following neodymium-YAG posterior capsulotomy (YPC)."9.07Prevention of the rise in intraocular pressure following neodymium-YAG posterior capsulotomy using topical clonidine. ( Geyer, O; Lazar, M; Loewenstein, A; Varssano, D, 1991)
"We conducted a randomly assigned, double-masked, controlled clinical trial to assess the efficacy of 1% apraclonidine hydrochloride in controlling postoperative intraocular pressure increases in patients undergoing extracapsular cataract extraction."9.07Control of intraocular pressure with apraclonidine hydrochloride after cataract extraction. ( Ide, CH; MacKenzie, D; Wiles, SB, 1991)
"The authors compared the additive intraocular pressure (IOP)-lowering effects of two different topical medications, apraclonidine hydrochloride and dipivefrin hydrochloride, when used in conjunction with timolol maleate."9.06Adjunctive glaucoma therapy. A comparison of apraclonidine to dipivefrin when added to timolol maleate. ( Morrison, JC; Robin, AL, 1989)
"0% apraclonidine hydrochloride in 15 normal volunteers and 17 subjects with increased intraocular pressure."9.06A limited comparison of apraclonidine's dose response in subjects with normal or increased intraocular pressure. ( Abrams, DA; Caldwell, DR; Crandall, AS; Pollack, IP; Rader, JE; Reaves, TA; Robin, AL; Schnitzer, DB, 1989)
"The effects of clonidine on intraocular pressure and perioperative cardiovascular variables were studied by a randomized double blind design in 80 elderly patients (ASA physical status I-III) scheduled for elective ophthalmic surgery under general anesthesia (GA) and local anesthesia (LA)."9.06Anesthesia for ophthalmic surgery in the elderly: the effects of clonidine on intraocular pressure, perioperative hemodynamics, and anesthetic requirement. ( Calvillo, O; Ghignone, M; Noe, C; Quintin, L, 1988)
"A prospective, randomized, double-masked pilot study compared topical 1% ALO 2145 (p-aminoclonidine hydrochloride, a topical alpha 2-agonist) with a placebo to determine its ability to minimize any acute postoperative intraocular pressure (IOP) increase after argon laser iridotomy."9.06Effects of topical ALO 2145 (p-aminoclonidine hydrochloride) on the acute intraocular pressure rise after argon laser iridotomy. ( deFaller, JM; Pollack, IP; Robin, AL, 1987)
"We studied apraclonidine hydrochloride (aplonidine hydrochloride or ALO 2145), an alpha-agonist, for its effect on the intraocular pressure (IOP) rise following neodymium-YAG posterior capsulotomy (YPC)."9.06Prevention of the rise in intraocular pressure following neodymium-YAG posterior capsulotomy using topical 1% apraclonidine. ( Brown, RH; Crandall, AS; Pollack, IP; Robin, AL; Stewart, RH; White, GL, 1988)
"25% solutions of clonidine hydrochloride by comparison with a 2% pilocarpine hydrochloride solution and placebo was carried out in a total of 21 patients with open-angle glaucoma, each of whom received a single drop of each preparation in the same glaucomatous eye on separate days."9.04Clonidine. Effects of a topically administered solution on intraocular pressure and blood pressure in open-angle glaucoma. ( Harrison, R; Kaufmann, CS, 1977)
"To investigate the effects of apraclonidine on intraocular pressure elevation after cataract surgery and the factors associated with elevated intraocular pressure."7.80[Factors influencing intraocular pressure elevation on the first postoperative day following small-incision cataract surgery--the effect of apraclonidine]. ( Ando, H; Ando, N; Eguchi, R; Ishikawa, N; Takagi, C, 2014)
"To determine the incidence of intraocular pressure (IOP) rise of varying degrees after laser peripheral iridotomy (LPI) in patients with and without glaucoma treated perioperatively with pilocarpine and apraclonidine."7.70The rarity of clinically significant rise in intraocular pressure after laser peripheral iridotomy with apraclonidine. ( Gangnon, R; Heatley, GA; Kaufman, PL; Lewis, R; Perkins, TW, 1998)
"This pilot study evaluated the acute effects of topical ocular apraclonidine 1% (Iopidine) in 10 patients with presumed silicone oil-induced secondary glaucoma (SOIG) and in 10 patients with high-pressure primary open-angle glaucoma (POAG) despite maximum tolerated medical therapy."7.69Efficacy of apraclonidine ophthalmic solution (Iopidine) in presumed silicon oil-induced glaucoma and primary open-angle glaucoma. ( Busche, S; Gramer, E; Kampik, A; Parsons, D, 1995)
"5% apraclonidine may be a useful adjunct to other antiglaucoma treatment modalities in dogs, but is unlikely to be effective as the sole agent in most forms of canine glaucoma."7.69Effects of topical administration of 0.5% apraclonidine on intraocular pressure, pupil size, and heart rate in clinically normal dogs. ( Miller, PE; Nelson, MJ; Rhaesa, SL, 1996)
"5% apraclonidine, on intraocular pressure (IOP), pupil size, and heart rate in clinically normal cats."7.69Effects of topical administration of 0.5% apraclonidine on intraocular pressure, pupil size, and heart rate in clinically normal cats. ( Miller, PE; Rhaesa, SL, 1996)
"0% apraclonidine in preventing intraocular pressure (IOP) spike after argon laser trabeculoplasty (ALT) in patients on chronic apraclonidine therapy compared with patients not on chronic apraclonidine use."7.69Chronic use of apraclonidine decreases its moderation of post-laser intraocular pressure spikes. ( Birt, CM; Chung, HS; Hakimzadeh, R; Juzych, MS; Kim, C; Lee, D; Levin, DS; Shin, DH, 1997)
"The effects of the selective alpha2-adrenergic agonist p-aminoclonidine, the nonselective adrenergic agonist epinephrine, the selective beta2-adrenergic agonist fenoterol and the adenosine A1 agonist R-PIA on intraocular pressure were studied in control and pertussis toxin-pretreated rabbits."7.69Effects of drugs acting on adrenergic and adenosine receptors on the intraocular pressure and the activity of adenylyl cyclase in ciliary processes and their sensitivity to pertussis toxin. ( Caicedo, M; Cepelík, J; Dedina, M; Hynie, S, 1997)
"We retrospectively compared the incidence and level of postoperative intraocular pressure (IOP) spikes in 53 consecutive glaucoma patients undergoing Nd:YAG posterior capsulotomy (YPC) who received apraclonidine immediately postoperatively, with those occurring in 22 consecutive similar patients who did not receive apraclonidine."7.68The effect of apraclonidine on the intraocular pressure of glaucoma patients following Nd:YAG laser posterior capsulotomy. ( Cullom, RD; Schwartz, LW, 1993)
"The contribution of sympathetic cervical ganglion to the mechanism of action of clonidine for lowering intraocular pressure (IOP) was investigated."7.68[The role of sympathetic cervical ganglion in the effect of clonidine for lowering intraocular pressure]. ( Fukado, Y; Iizuka, T; Inatomi, M; Kobayashi, S; Koide, R; Koike, N; Moriwaki, Y; Oguchi, K; Uchida, E; Ueda, T, 1992)
"We evaluated the effectiveness of topical apraclonidine (ALO 2145, p-amino clonidine hydrochloride) in suppressing an acute postoperative intraocular pressure (IOP) rise following Nd:YAG laser iridotomy."7.67Use of apraclonidine to reduce acute intraocular pressure rise following Q-switched Nd:YAG laser iridotomy. ( Kitazawa, Y; Sugiyama, K; Taniguchi, T, 1989)
"We evaluated the ability of topical clonidine to suppress an acute rise in postoperative intraocular pressure (IOP) following Nd:YAG laser iridotomy."7.67The prevention of an acute rise in intraocular pressure following Q-switched Nd:YAG laser iridotomy with clonidine. ( Kitazawa, Y; Sugiyama, K; Taniguchi, T, 1989)
"The effects of 3-[2-[4-(2-methylphenyl)-1- piperazinyl]ethyl]-5,6,7,8-tetrahydro-1,2,4-triazolo[4,3-a]pyridine HCl (dapiprazole), a new drug with alpha-adrenergic blocking properties, on pupillary diameter and intraocular pressure have been studied in rabbits."7.66Effects of dapiprazole on pupillary size and intraocular pressure in rabbits. ( Baldini, A; Belluci, R; Bonomi, L; Lisciani, R; Massa, F; Perfetti, S; Silvestrini, B, 1982)
"The peripheral and central neural actions of clonidine on normal and glaucomatous eyes have been investigated."7.66The peripheral and central neural actions of clonidine in normal and glaucomatous eyes. ( Krieglstein, GK; Langham, ME; Leydhecker, W, 1978)
"The rise in intraocular pressure (IOP) observed after the administration of clonidine into the carotid arteries was studied in anesthetized rats and cats."7.66An increase in intraocular pressure due to clonidine. ( Innemee, HC; van Zwieten, PA, 1978)
"In order to study the influence of clonidine on intraocular pressure (IOP), the drug was administered via different routes."7.66The influence of clonidine on intraocular pressure. ( Innemee, HC; van Zwieten, PA, 1979)
"A study has been made of the time courses of the pupillary and intraocular pressure responses of conscious rabbits to clonidine administered either topically or intravenously."7.65The intraocular pressure response of conscious rabbits to clonidine. ( Allen, RC; Langham, ME, 1976)
"Intraocular pressure was measured by a masked observer, using Goldmann applanation tonometry, before and 1 hour after the treatment."6.69Apraclonidine 0.5% versus brimonidine 0.2% for the control of intraocular pressure elevation following anterior segment laser procedures. ( Assalian, A; Chevrier, RL; Duperré, J; Lesk, MR, 1999)
"Apraclonidine 1."6.69Reversal of intraocular pressure increases with 0.5% apraclonidine after dilated fundus examination in patients with chronic open-angle glaucoma. ( Chang, FW; Kolin, T; Nishimoto, JH; Tang, IH, 1999)
"In apraclonidine-treated eyes the IOP fell from a mean of 15."6.66Effectiveness of apraclonidine in preventing the rise in intraocular pressure after neodymium:YAG posterior capsulotomy. ( Brown, RH; Crandall, AS; Pollack, IP; Robin, AL; Stewart, RH; White, GL, 1988)
"5% apraclonidine on Intraocular pressure (IOP) in horses and compare the effects of timolol maleate 0."5.51Effect of Topically Applied 0.5% Apraclonidine Versus 0.5% Timolol Maleate on Intraocular Pressure of Healthy Horses. ( Asghari, A; Ozmaie, S; Rajaei, SM; Ziadi, A, 2022)
"PRéCIS:: Adjuvant diclofenac and apraclonidine eye drop given in conjunction with selective laser trabeculoplasty (SLT) do not significantly impact medium-term intraocular pressure (IOP) reduction compared with placebo, but apraclonidine can be used to blunt immediate postlaser pressure spikes."5.34Effect of Apraclonidine and Diclofenac on Early Changes in Intraocular Pressure After Selective Laser Trabeculoplasty. ( Bergo, C; Halvorsen, H; Krohn, J; Thrane, AS; Thrane, VR, 2020)
"Clonidine was topically applied to the right eye of anesthetized cats."5.26The influence of clonidine on intraocular pressure after topical application to the eyes of anesthetized cats. ( Hermans, AJ; Innemee, HC; van Zwieten, PA, 1979)
"To evaluate the efficacy of preoperative oral clonidine (5 g/kg) in preventing ocular hypertension in the early period after cataract surgery with posterior chamber intraocular lens implantation under general anaesthesia."5.16Effect of oral clonidine on acute intraocular pressure rise after cataract extraction under general anaesthesia. ( Boroojeny, SB; Fard, MM, 2012)
"05 mL of bevacizumab or ranibizumab), that were divided into five groups, group 1: no intraocular pressure (IOP)-lowering medication (n=50); group 2: apraclonidine 1 % one drop 2 hours prior to IVI (n=50); group 3: acetazolamide 250 mg 2 hours prior (n=50); group 4: fixed combination brimonidine+timolol (n=30); group 5: fixed combination dorzolamide+timolol (n=30)."5.16[Efficacy of prophylactic treatment of intraocular pressure spikes due to intravitreal injections]. ( Dot, C; El Chehab, H; Giraud, JM; Le Corre, A; Ract-Madoux, G; Swalduz, B, 2012)
"To determine the efficacy and safety of oral clonidine in decreasing the prevalence and intensity of postoperative intraocular pressure (IOP) rise in those undergoing phacoemulsification."5.15Effect of oral clonidine on acute intraocular pressure rise after phacoemulsification: a prospective double-blind, randomized, clinical trial. ( Boroojeny, SB; Fard, MM; Ghaffarpasand, F; Hourang, MH; Zakeri, H; Zeraatian, S, 2011)
"Clonidine significantly decreased mean arterial pressure (MAP) and intraocular pressure (IOP)."5.12Intravenous administration of clonidine reduces intraocular pressure and alters ocular blood flow. ( Fuchsjager-Mayrl, G; Garhofer, G; Luksch, A; Reitsamer, HA; Resch, H; Schmetterer, L; Weigert, G, 2007)
"Clonidine and brimonidine, two alpha-2 agonists, have been shown to reduce intraocular pressure (IOP) in patients with glaucoma."5.12Effects of topical clonidine versus brimonidine on choroidal blood flow and intraocular pressure during squatting. ( Fuchsjäger-Mayrl, G; Garhofer, G; Resch, H; Schmetterer, L; Weigert, G, 2007)
"To determine the 1- and 3-hour changes in intraocular pressure after neodymium:yttrium-aluminum-garnet (Nd:YAG) capsulotomy in pseudophakic patients with glaucoma and to determine the effect of acetazolamide and apraclonidine on these changes."5.11Neodymium:yttrium-aluminum-garnet capsulotomy and intraocular pressure in pseudophakic patients with glaucoma. ( Barnes, EA; Behrend, M; Cahill, A; Kehoe, B; Murdoch, IE; Subramaniam, S, 2004)
"To evaluate the effectiveness of prophylactic topical apraclonidine 1% in preventing an intraocular pressure (IOP) rise in the early period after uneventful phacoemulsification with intraocular lens (IOL) implantation."5.10Preventing intraocular pressure increase after phacoemulsification and the role of perioperative apraclonidine. ( Desai, SP; Kasetti, SR; Sivakumar, S; Sunderraj, P, 2002)
" Both reduce intraocular pressure in the timolol-treated eye, primarily, if not exclusively, by further suppressing aqueous flow."5.09Comparison of the early effects of brimonidine and apraclonidine as topical ocular hypotensive agents. ( Brubaker, RF; Maus, TL; Nau, C, 1999)
"2% topical medication or the replacement of apraclonidine with brimonidine resulted in a significant decrease in mean intraocular pressure from 20."5.09Long-term brimonidine therapy in glaucoma patients with apraclonidine allergy. ( Cha, SC; Glover, BK; Kim, C; Kim, YY; Nguyen, KD; Shin, DH, 1999)
"The authors compared the efficacy of apraclonidine 1% versus pilocarpine 4% prophylaxis of post-argon laser trabeculoplasty (ALT) intraocular pressure (IOP) spike."5.09Efficacy of apraclonidine 1% versus pilocarpine 4% for prophylaxis of intraocular pressure spike after argon laser trabeculoplasty. ( Birt, CM; Chung, HS; Glover, BK; Hughes, BA; Juzych, MS; Kim, C; Ren, J; Shin, DH, 1999)
"2% can control intraocular pressure (IOP) spikes as well as apraclonidine 1."5.09Control of intraocular pressure elevations after argon laser trabeculoplasty: comparison of brimonidine 0.2% to apraclonidine 1.0%. ( Barnes, SD; Campagna, JA; Dirks, MS; Doe, EA, 1999)
" Following the addition of apraclonidine the mean, peak and range of IOP were statistically similar between groups and only the standard deviations remained higher in the exfoliation glaucoma group (p < 0."5.09The comparative ocular hypotensive effect of apraclonidine with timolol maleate in exfoliation versus primary open-angle glaucoma patients. ( Konstas, AG; Maltezos, A; Mantziris, DA; Sine, CS; Stewart, WC, 1999)
"Topical timolol and apraclonidine significantly reduced the intraocular pressure."5.09A comparative study on the effects of apraclonidine and timolol on the ophthalmic blood flow velocity waveforms. ( Oruç, S; Sener, EC, 1999)
"We determined whether the addition of topical apraclonidine hydrochloride to eyes that are receiving maximal medical therapy but still have inadequate intraocular pressure control and that are scheduled to undergo surgery could adequately decrease intraocular pressure, postponing the need for further intervention."5.08Short-term efficacy of apraclonidine hydrochloride added to maximum-tolerated medical therapy for glaucoma. Apraclonidine Maximum-Tolerated Medical Therapy Study Group. ( Lehmann, RP; Mundorf, T; Ritch, R; Robin, AL; Shin, DH; Smythe, B, 1995)
"The mechanism by which apraclonidine, an alpha 2-adrenergic agonist, lowers intraocular pressure (IOP) was evaluated in humans."5.08Effects of apraclonidine on aqueous humor dynamics in human eyes. ( Camras, CB; Tafoya, ME; Toris, CB; Yablonski, ME, 1995)
"We determined whether the addition of topical apraclonidine hydrochloride to eyes receiving maximal medical therapy, with inadequate intraocular pressure (IOP) control, and scheduled to undergo surgery, could adequately lower IOP, postponing the need for surgical intervention."5.08Topical apraclonidine hydrochloride in eyes with poorly controlled glaucoma. The Apraclonidine Maximum Tolerated Medical Therapy Study Group. ( Lehmann, RP; Mundorf, T; Ritch, R; Robin, AL; Shin, D; Smythe, B, 1995)
"Topical apraclonidine hydrochloride 1% is effective for controlling the intraocular pressure (IOP) rise following argon laser trabeculoplasty (ALT)."5.08Apraclonidine 0.5% versus 1% for controlling intraocular pressure elevation after argon laser trabeculoplasty. ( Allingham, RR; Assalian, AA; Shields, MB; Threlkeld, AB, 1996)
"0% apraclonidine in preventing laser-induced intraocular pressure (IOP) elevation after trabeculoplasty, neodymium: YAG (Nd: YAG) iridotomy, and capsulotomy."5.08Apraclonidine and anterior segment laser surgery. Comparison of 0.5% versus 1.0% apraclonidine for prevention of postoperative intraocular pressure rise. ( Gieser, DK; Grewal, RK; Karalekas, DP; Krupin, T; McDaniel, DL; Rosenberg, LF; Ruderman, J; Siegfried, C; Williams, R, 1995)
"The intraocular pressure was reduced significantly in apraclonidine treated eyes by 15."5.08Effects of 0.5% apraclonidine on optic nerve head and peripapillary retinal blood flow. ( Kim, DM; Kim, TW, 1997)
"To measure the effect of 1% apraclonidine hydrochloride eyedrops on intraocular pressure (IOP) after cataract surgery."5.08The effect of 1% apraclonidine on intraocular pressure after cataract surgery. ( Renzenbrink-Bubberman, AC; Sterk, CC; van Best, JA, 1998)
"Apraclonidine suppressed aqueous humor flow between 39% and 44% and lowered intraocular pressure between 20% and 23%."5.08Comparison of the efficacy of apraclonidine and brimonidine as aqueous suppressants in humans. ( Brubaker, RF; Maus, TL; Nau, CB; Schadlu, R, 1998)
"To investigate if apraclonidine can effectively prevent the acute increase of intraocular pressure (IOP) in brown eyes with Nd:YAG laser iridectomy."5.08[Apraclonidine prevents the acute increase of intraocular pressure in brown eyes with Nd:YAG laser iridectomy]. ( Liu, X; Mao, J; Zhao, J, 1998)
"Apraclonidine and pilocarpine have been shown to be effective in reducing the incidence of intraocular pressure (IOP) spikes following argon laser trabeculoplasty."5.07Influence of apraclonidine and pilocarpine alone and in combination on post laser trabeculoplasty pressure rise. ( Cunliffe, IA; Dapling, RB; Longstaff, S, 1994)
"Apraclonidine effectively decreased large IOP elevations in glaucomatous eyes undergoing trabeculectomy combined with extracapsular cataract surgery."5.07Effect of topical apraclonidine on the frequency of intraocular pressure elevations after combined extracapsular cataract extraction and trabeculectomy. ( Robin, AL, 1993)
"To evaluate the effect of topical apraclonidine on early postoperative intraocular pressure and blood-aqueous barrier permeability, we conducted a double-masked clinical trial in which 37 patients undergoing uncomplicated phacoemulsification and posterior chamber intraocular lens implantation were randomly assigned to treatment with 1% apraclonidine or its vehicle."5.07Effects of apraclonidine on intraocular pressure and blood-aqueous barrier permeability after phacoemulsification and intraocular lens implantation. ( Araie, M; Ishi, K, 1993)
"Apraclonidine effectively lowers IOP associated with open-angle glaucoma or ocular hypertension; these pilot results will need to be confirmed by a larger pivotal study."5.07Comparison of apraclonidine and timolol in chronic open-angle glaucoma. A three-month study. ( Chuniaud, M; Demailly, P; Hitchings, RA; Nagasubramanian, S; Pannarale, MR; Parsons, DG; Pecori-Giraldi, J; Stodtmeister, R, 1993)
"The objective of the study was to assess the effects of premedication with clonidine on intraocular pressure (IOP) after the administration of succinylcholine."5.07Oral clonidine premedication prevents the rise in intraocular pressure following succinylcholine administration. ( Böhrer, H; Martin, E; Polarz, H; Völcker, HE; Wolfrum, J, 1993)
"Seventeen patients with glaucoma were given bilaterally a single drop of Isoglaucon (Clonidine hydrochloride) of various volume (15 microliters and 40 microliters) and various concentrations of the drug (0."5.07[Various clonidine drops in treatment of glaucoma]. ( Brozyna-Zyłka, B; Otrzonsek, D; Sobieraj, A; Szymański, A, 1992)
"We evaluated the prophylactic effect of 1% apraclonidine HCl in controlling the increase in intraocular pressure after Nd:YAG posterior capsulotomy in a large, multicenter double-masked clinical trial."5.07Prophylactic use of apraclonidine for intraocular pressure increase after Nd:YAG capsulotomies. ( Brint, SF; Burk, LL; deFaller, JM; McCarty, GR; Olander, KW; Silverstone, DE; Taylor, RB, 1992)
"Sixty patients with medically uncontrolled open-angle glaucoma (intraocular pressure greater than 21 mm Hg) were randomly assigned to one of two treatment regimens with apraclonidine before undergoing 360-degree argon laser trabeculoplasty."5.07Apraclonidine and argon laser trabeculoplasty. ( Brodstein, DE; Chase, RD; Chopra, H; Goldenfeld, M; Holmwood, PC; Krupin, T; Rosenberg, LF; Ruderman, JM; Tallman, BA, 1992)
"We performed a prospective, randomized double blind study comparing the cardiovascular and intraocular pressure (IOP) effects of unilateral therapy with clonidine 0."5.07Apraclonidine and clonidine: a comparison of efficacy and side effects in normal and ocular hypertensive volunteers. ( Caglar, Y; Elibol, O; Güler, C; Yüksel, N, 1992)
"The short-term additive effect and side effects of adding 1% apraclonidine hydrochloride to nonselective beta-blockers were investigated in 21 patients with ocular hypertension or early primary open-angle glaucoma."5.07Additive effect of 1% apraclonidine hydrochloride to nonselective beta-blockers. ( Lee, SH; Lee, SY; Parrow, KA; Shin, DH; Yaldo, MK, 1991)
"A randomized, prospective, double-masked study was undertaken to determine the risk of postcycloplegic intraocular pressure spikes in patients with open-angle glaucoma and to evaluate apraclonidine prophylaxis in minimizing these spikes."5.07Apraclonidine prophylaxis for postcycloplegic intraocular pressure spikes. ( Baerveldt, G; Heuer, DK; Hill, RA; Lee, M; Martone, JF; Minckler, DS, 1991)
"To determine the effect of apraclonidine hydrochloride on the acute intraocular pressure (IOP) rise after argon laser iridotomy (ALI), a double-masked comparative study was carried out."5.07Effect of apraclonidine hydrochloride on acute introacular pressure rise after argon laser iridotomy. ( Hong, C; Park, WH; Sohn, YH; Song, KY, 1991)
"We conducted a randomly assigned, double-masked, controlled clinical trial to assess the efficacy of 1% apraclonidine hydrochloride in controlling postoperative intraocular pressure increases in patients undergoing extracapsular cataract extraction."5.07Control of intraocular pressure with apraclonidine hydrochloride after cataract extraction. ( Ide, CH; MacKenzie, D; Wiles, SB, 1991)
"The authors compared the additive intraocular pressure (IOP)-lowering effects of two different topical medications, apraclonidine hydrochloride and dipivefrin hydrochloride, when used in conjunction with timolol maleate."5.06Adjunctive glaucoma therapy. A comparison of apraclonidine to dipivefrin when added to timolol maleate. ( Morrison, JC; Robin, AL, 1989)
"0% apraclonidine hydrochloride in 15 normal volunteers and 17 subjects with increased intraocular pressure."5.06A limited comparison of apraclonidine's dose response in subjects with normal or increased intraocular pressure. ( Abrams, DA; Caldwell, DR; Crandall, AS; Pollack, IP; Rader, JE; Reaves, TA; Robin, AL; Schnitzer, DB, 1989)
"0% apraclonidine (para-aminoclonidine) in preventing the rise of intraocular pressure following anterior segment, laser surgery was evaluated in a randomised double-masked study."5.06Efficacy and safety of apraclonidine in patients undergoing anterior segment laser surgery. ( Badrinath, SS; Sridharrao, B, 1989)
"We performed a double-masked, cross-over, dose-response study of apraclonidine hydrochloride (formerly known as ALO 2145) in 20 patients with elevated intraocular pressure (IOP)."5.06Apraclonidine. A one-week dose-response study. ( Jampel, HD; Pollack, IP; Quigley, HA; Robin, AL, 1988)
"The effect of an alpha adrenergic agonist, ALO 2145 (para-amino-clonidine [PAC]), was examined in a double-masked, multicenter study on the postoperative intraocular pressure (IOP) elevation after laser surgery in 165 patients (83 trabeculoplasty, 36 iridotomy, and 46 capsulotomy)."5.06ALO 2145 reduces the intraocular pressure elevation after anterior segment laser surgery. ( Brown, RH; Crandall, AS; DeFaller, JM; Gaasterland, DE; Higginbotham, EJ; Lynch, MG; Mandell, AI; Schwartz, AL; Stewart, RH; Wilensky, JT, 1988)
"The effects of clonidine on intraocular pressure and perioperative cardiovascular variables were studied by a randomized double blind design in 80 elderly patients (ASA physical status I-III) scheduled for elective ophthalmic surgery under general anesthesia (GA) and local anesthesia (LA)."5.06Anesthesia for ophthalmic surgery in the elderly: the effects of clonidine on intraocular pressure, perioperative hemodynamics, and anesthetic requirement. ( Calvillo, O; Ghignone, M; Noe, C; Quintin, L, 1988)
"A prospective, randomized, double-masked pilot study compared topical 1% ALO 2145 (p-aminoclonidine hydrochloride, a topical alpha 2-agonist) with a placebo to determine its ability to minimize any acute postoperative intraocular pressure (IOP) increase after argon laser iridotomy."5.06Effects of topical ALO 2145 (p-aminoclonidine hydrochloride) on the acute intraocular pressure rise after argon laser iridotomy. ( deFaller, JM; Pollack, IP; Robin, AL, 1987)
"We studied apraclonidine hydrochloride (aplonidine hydrochloride or ALO 2145), an alpha-agonist, for its effect on the intraocular pressure (IOP) rise following neodymium-YAG posterior capsulotomy (YPC)."5.06Prevention of the rise in intraocular pressure following neodymium-YAG posterior capsulotomy using topical 1% apraclonidine. ( Brown, RH; Crandall, AS; Pollack, IP; Robin, AL; Stewart, RH; White, GL, 1988)
"25% solutions of clonidine hydrochloride by comparison with a 2% pilocarpine hydrochloride solution and placebo was carried out in a total of 21 patients with open-angle glaucoma, each of whom received a single drop of each preparation in the same glaucomatous eye on separate days."5.04Clonidine. Effects of a topically administered solution on intraocular pressure and blood pressure in open-angle glaucoma. ( Harrison, R; Kaufmann, CS, 1977)
"Clonidine hydrochloride, apraclonidine hydrochloride, and brimonidine tartrate constitute the three topical alpha agonists that are used in the treatment of elevated intraocular pressure."4.80Selectivity of site of action and systemic effects of topical alpha agonists. ( Burnstein, Y; Robin, AL, 1998)
"5% para-amino-clonidine (PAC), an adrenergic alpha 2 agonist, on intraocular pressure (IOP), protein and prostaglandin E2 (PGE2) concentration in aqueous humor following the laser application to the iris of albino rabbits."3.72The effect of alpha2-agonist on IOP rise following Nd-YAG laser iridotomy. ( Kawai, K; Kitazawa, Y; Sugiyama, K, 2004)
"To determine the incidence of intraocular pressure (IOP) rise of varying degrees after laser peripheral iridotomy (LPI) in patients with and without glaucoma treated perioperatively with pilocarpine and apraclonidine."3.70The rarity of clinically significant rise in intraocular pressure after laser peripheral iridotomy with apraclonidine. ( Gangnon, R; Heatley, GA; Kaufman, PL; Lewis, R; Perkins, TW, 1998)
"We studied the acute effects of the ocular hypotensive drug, apraclonidine (AP), on intraocular pressure (IOP) and aqueous humor dynamics of anesthetized rats during infusion-induced ocular hypertension."3.70Aqueous humor dynamics in anesthetized rats infused with intracameral apraclonidine. ( Balaban, CD; Searles, RV; Severs, WB; Shikher, V, 1999)
"To determine the location of action of apraclonidine, an alpha-adrenergic receptor agonist that reduces aqueous production and lowers intraocular pressure (IOP)."3.70Ocular effects of apraclonidine in Horner syndrome. ( Abdul-Rahim, AS; Brown, SM; Crosson, CE; Morales, J, 2000)
"Apraclonidine and brimonidine administered topically to one eye of ketamine-anesthetized normal cynomolgus monkeys each produced a dose-related bilateral reduction in intraocular pressure which was not dependent on intact sympathetic innervation."3.69Apraclonidine and brimonidine effects on anterior ocular and cardiovascular physiology in normal and sympathectomized monkeys. ( Debink, N; Gabelt, BT; Hubbard, WC; Kaufman, PL; Peterson, CM; Robinson, JC; Wadhwa, A, 1994)
"This pilot study evaluated the acute effects of topical ocular apraclonidine 1% (Iopidine) in 10 patients with presumed silicone oil-induced secondary glaucoma (SOIG) and in 10 patients with high-pressure primary open-angle glaucoma (POAG) despite maximum tolerated medical therapy."3.69Efficacy of apraclonidine ophthalmic solution (Iopidine) in presumed silicon oil-induced glaucoma and primary open-angle glaucoma. ( Busche, S; Gramer, E; Kampik, A; Parsons, D, 1995)
"We undertook a retrospective analysis of 64 patients receiving long-term 1% apraclonidine therapy at the University of California-San Francisco Glaucoma Service."3.69Clinical experience with the long-term use of 1% apraclonidine. Incidence of allergic reactions. ( Alvarado, J; Butler, P; Hwang, I; Lin, S; Mannschreck, M, 1995)
"5% apraclonidine may be a useful adjunct to other antiglaucoma treatment modalities in dogs, but is unlikely to be effective as the sole agent in most forms of canine glaucoma."3.69Effects of topical administration of 0.5% apraclonidine on intraocular pressure, pupil size, and heart rate in clinically normal dogs. ( Miller, PE; Nelson, MJ; Rhaesa, SL, 1996)
"0% apraclonidine in preventing intraocular pressure (IOP) spike after argon laser trabeculoplasty (ALT) in patients on chronic apraclonidine therapy compared with patients not on chronic apraclonidine use."3.69Chronic use of apraclonidine decreases its moderation of post-laser intraocular pressure spikes. ( Birt, CM; Chung, HS; Hakimzadeh, R; Juzych, MS; Kim, C; Lee, D; Levin, DS; Shin, DH, 1997)
"The effects of the selective alpha2-adrenergic agonist p-aminoclonidine, the nonselective adrenergic agonist epinephrine, the selective beta2-adrenergic agonist fenoterol and the adenosine A1 agonist R-PIA on intraocular pressure were studied in control and pertussis toxin-pretreated rabbits."3.69Effects of drugs acting on adrenergic and adenosine receptors on the intraocular pressure and the activity of adenylyl cyclase in ciliary processes and their sensitivity to pertussis toxin. ( Caicedo, M; Cepelík, J; Dedina, M; Hynie, S, 1997)
"We retrospectively compared the incidence and level of postoperative intraocular pressure (IOP) spikes in 53 consecutive glaucoma patients undergoing Nd:YAG posterior capsulotomy (YPC) who received apraclonidine immediately postoperatively, with those occurring in 22 consecutive similar patients who did not receive apraclonidine."3.68The effect of apraclonidine on the intraocular pressure of glaucoma patients following Nd:YAG laser posterior capsulotomy. ( Cullom, RD; Schwartz, LW, 1993)
"The effects of pertussis toxin on the intraocular pressure (IOP) lowering effect of clonidine and isoproterenol as well as on the inhibitory effects of clonidine and neuropeptide Y on adenylate cyclase activity of ciliary processes were studied in albino rabbits."3.68Effects of pertussis toxin on intraocular pressure and adenylate cyclase activity of ciliary processes in rabbits. ( Cepelík, J; Hynie, S, 1993)
") administration of phenylephrine, clonidine, guanfacine, prazosin, yohimbine on the intraocular pressure (IOP) was investigated in the rabbit."3.68[Ocular hypotensive effect of alpha-adrenoceptor agonist and antagonist in the conscious pigmented rabbit]. ( Fukado, Y; Iizuka, T; Inatomi, M; Koide, R; Masaoka, Y; Moriwaki, Y; Nakamura, A; Nakata, K; Uchida, E; Ueda, T, 1992)
"Apraclonidine (p-aminoclonidine) ophthalmic solution effectively reduces the rise in intraocular pressure (IOP) following anterior segment laser surgery."3.68Apraclonidine effects on ocular responses to YAG laser irradiation to the rabbit iris. ( Kawai, K; Kitazawa, Y; Sugiyama, K, 1990)
"We evaluated the effectiveness of topical apraclonidine (ALO 2145, p-amino clonidine hydrochloride) in suppressing an acute postoperative intraocular pressure (IOP) rise following Nd:YAG laser iridotomy."3.67Use of apraclonidine to reduce acute intraocular pressure rise following Q-switched Nd:YAG laser iridotomy. ( Kitazawa, Y; Sugiyama, K; Taniguchi, T, 1989)
"We evaluated the ability of topical clonidine to suppress an acute rise in postoperative intraocular pressure (IOP) following Nd:YAG laser iridotomy."3.67The prevention of an acute rise in intraocular pressure following Q-switched Nd:YAG laser iridotomy with clonidine. ( Kitazawa, Y; Sugiyama, K; Taniguchi, T, 1989)
"The ability of hypoosmotic solution, prostaglandin E1 (PGE1) and clonidine to influence intraocular pressure (IOP) by a central mechanism was studied using the technique of ventriculocisternal perfusion in conscious rabbits."3.67Study of central regulation of intraocular pressure using ventriculocisternal perfusion. ( Liu, JH; Neufeld, AH, 1985)
"The effects of 3-[2-[4-(2-methylphenyl)-1- piperazinyl]ethyl]-5,6,7,8-tetrahydro-1,2,4-triazolo[4,3-a]pyridine HCl (dapiprazole), a new drug with alpha-adrenergic blocking properties, on pupillary diameter and intraocular pressure have been studied in rabbits."3.66Effects of dapiprazole on pupillary size and intraocular pressure in rabbits. ( Baldini, A; Belluci, R; Bonomi, L; Lisciani, R; Massa, F; Perfetti, S; Silvestrini, B, 1982)
" Contrary to results obtained with clonidine, neither the fall in intraocular pressure (IOP), nor the arterial hypotension induced by delta 9-THC, were enhanced after the 'central' administration of the drug."3.66The influence of delta 9-tetrahydrocannabinol on intraocular pressure in the anaesthetized cat. ( Hermans, AJ; Innemee, HC; van Zwieten, PA, 1980)
"Experience obtained in the treatment of 78 eyes of patients suffering from open-angle glaucoma with the beta-blocker Timolol 0."3.66[Experience with timolol in consulting patients (author's transl)]. ( Junker, C; Junker, H, 1980)
"The peripheral and central neural actions of clonidine on normal and glaucomatous eyes have been investigated."3.66The peripheral and central neural actions of clonidine in normal and glaucomatous eyes. ( Krieglstein, GK; Langham, ME; Leydhecker, W, 1978)
"The rise in intraocular pressure (IOP) observed after the administration of clonidine into the carotid arteries was studied in anesthetized rats and cats."3.66An increase in intraocular pressure due to clonidine. ( Innemee, HC; van Zwieten, PA, 1978)
"The influence of clonidine on intraocular pressure was studied in chloralose-anesthetized cats."3.66The influence of acute and chronic cervical sympathectomy on the ocular hypotensive effect of clonidine. ( Innemee, HC; van Ommeren, JD; van Zwieten, PA, 1979)
"A study has been made of the time courses of the pupillary and intraocular pressure responses of conscious rabbits to clonidine administered either topically or intravenously."3.65The intraocular pressure response of conscious rabbits to clonidine. ( Allen, RC; Langham, ME, 1976)
"The intraocular pressures were measured at regular intervals during the 6-months follow-up period."2.80Influence on intraocular pressure of anti-inflammatory treatments after selective laser trabeculoplasty. ( Anctil, JL; Champagne, S; Des Marchais, B; Goyette, A; Lajoie, C, 2015)
"25% drops in twice daily dosage and does not result in any significant ocular and systemic adverse effects."2.70A prospective, long-term, randomized study of the efficacy and safety of the drug combination pilocarpine 1% with clonidine 0.06% or clonidine 0.125% versus timolol 0.25%. ( Agarwal, H; Rajashekhar, YL; Sihota, R; Venkatesh, P, 2002)
"Intraocular pressure was measured preoperatively and 4 to 6 and 24 hours postoperatively."2.69Medical control of intraocular pressure after cataract surgery. ( Byrd, S; Singh, K, 1998)
"Intraocular pressure was measured by a masked observer, using Goldmann applanation tonometry, before and 1 hour after the treatment."2.69Apraclonidine 0.5% versus brimonidine 0.2% for the control of intraocular pressure elevation following anterior segment laser procedures. ( Assalian, A; Chevrier, RL; Duperré, J; Lesk, MR, 1999)
"Apraclonidine 1."2.69Reversal of intraocular pressure increases with 0.5% apraclonidine after dilated fundus examination in patients with chronic open-angle glaucoma. ( Chang, FW; Kolin, T; Nishimoto, JH; Tang, IH, 1999)
"5% timolol maleate twice daily for at least 4 weeks and who had 8 AM IOPs of at least 22 mm Hg and no greater than 30 mm Hg 12 hours after dosing were eligible for the study."2.68The efficacy of apraclonidine as an adjunct to timolol therapy. Apraclonidine Adjunctive Therapy Study Group. ( Lehmann, RP; Ritch, R; Shin, DH; Shrader, CE; Stewart, WC; van Buskirk, EM, 1995)
"5% timolol 8 hours after dosing on days 1, 30, and 90; and a significant difference (P < ."2.68A 90-day study of the efficacy and side effects of 0.25% and 0.5% apraclonidine vs 0.5% timolol. Apraclonidine Primary Therapy Study Group. ( Horwitz, B; Kottler, M; Laibovitz, R; Ritch, R; Stewart, RH; Stewart, WC, 1996)
"The single dose response of open angle glaucoma eyes to pilocarpine 1%, clonidine 0."2.68A comparative evaluation of pilocarpine 1% and clonidine 0.125% versus timolol 0.5%. ( Agarwal, HC; Rajashekar, YL; Sihota, R, 1996)
"diazepam was given in the control group than in the clonidine group (P less than 0."2.67Oral clonidine premedication for elderly patients undergoing intraocular surgery. ( Bhattacharya, A; Bose, S; Kumar, A; Kundra, P; Tandon, OP, 1992)
"When apraclonidine and timolol were given together in the daytime, no clinically significant or statistically significant additive effect was observed."2.67Apraclonidine and timolol. Combined effects in previously untreated normal subjects. ( Brubaker, RF; Koskela, T, 1991)
"Apraclonidine was found to significantly decrease conjunctival oxygen tension 76% at 1 hour compared with baseline values."2.66The effects of apraclonidine on conjunctival oxygen tension. ( Galustian, J; Lewis, RA; Serdahl, CL, 1989)
"In apraclonidine-treated eyes the IOP fell from a mean of 15."2.66Effectiveness of apraclonidine in preventing the rise in intraocular pressure after neodymium:YAG posterior capsulotomy. ( Brown, RH; Crandall, AS; Pollack, IP; Robin, AL; Stewart, RH; White, GL, 1988)
"Clonidine-treated eyes had a 2 mmHg decrease in intraocular pressure which was statistically significant."2.65Effect of clonidine on aqueous humor flow in normal human eyes. ( Brubaker, RF; Lee, DA; Topper, JE, 1984)
"Apraclonidine is a alpha 2 adrenergic agonic which is a para-amino derivative of clonidine."2.39[Effect and side effects of apraclonidine]. ( Stewart, WC, 1996)
"The aim of all treatment for glaucoma is to lower intra-ocular pressure."2.38[Pharmacology aspects of glaucoma]. ( Alm, A; Berggren, L, 1992)
"We document the recurrence of a CSMD in a patient subsequent to the instillation of topical ocular hypotensive medications and its resolution on discontinuation of therapy."1.35Recurrent serous macular detachment after topical ocular hypotensive medication. ( Besada, E; Frauens, BJ; Shechtman, D, 2008)
"Clonidine did not cause allergic reaction in patients with proven allergy to apraclonidine, indicating that there is no cross-reactivity with apraclonidine."1.31Clonidine provides an allergy-free alternative in glaucoma patients with proven allergy to apraclonidine. ( Geyer, O; Lazar, M; Neudorfer, M; Pianka, P; Schmidt, KG, 2000)
"Apraclonidine-treated eyes showed mydriasis and blanching of the conjunctiva."1.29Apraclonidine protection of the blood-aqueous barrier from traumatic break-down. ( Bellucci, R; Bonomi, L; Pagliarusco, A; Stefani, L, 1995)
"To evaluate the effect of the chronic use of apraclonidine 0."1.29Long term effect of apraclonidine. ( Araujo, SV; Bond, JB; Moster, MR; Schmidt, CM; Spaeth, GL; Wilson, RP, 1995)
"The author presents conservative treatment of glaucoma."1.28[Conservative treatment of glaucoma]. ( Tost, M, 1989)
"Xylazine is an agent frequently used in combination with ketamine to anesthetize rabbits."1.27The ocular effects of xylazine in rabbits, cats, and monkeys. ( Burke, JA; Potter, DE, 1986)
"Clonidine was administered into the left vertebral artery of anesthetized cats."1.26The central ocular hypotensive effect of clonidine. ( Innemee, HC; van Zwieten, PA, 1979)
"Clonidine hydrochloride has been demonstrated to produce vasoconstriction in the anterior segment of the cat eye."1.26Clonidine. ( Cevario, SJ; Macri, FJ, 1978)
"The intraocular pressure was well controlled in 9 of these, and sufficiently lowered in the remaining two."1.26[Treatment results with isoglaucon eye drops in sympatheticotone patients with early appearing primary glaucoma (author's transl)]. ( Marquardt, R, 1977)

Research

Studies (225)

TimeframeStudies, this research(%)All Research%
pre-199080 (35.56)18.7374
1990's106 (47.11)18.2507
2000's28 (12.44)29.6817
2010's9 (4.00)24.3611
2020's2 (0.89)2.80

Authors

AuthorsStudies
Munk, SA1
Harcourt, D1
Ambrus, G1
Denys, L1
Gluchowski, C1
Burke, JA3
Kharlamb, AB1
Manlapaz, CA1
Padillo, EU1
Runde, E1
Williams, L1
Wheeler, LA1
Garst, ME1
Ziadi, A1
Ozmaie, S1
Asghari, A1
Rajaei, SM1
Thrane, VR1
Thrane, AS1
Bergo, C1
Halvorsen, H1
Krohn, J1
Boroojeny, SB2
Fard, MM2
Eguchi, R1
Takagi, C1
Ishikawa, N1
Ando, H1
Ando, N1
Celik, E1
Turkoglu, EB1
Altun, G1
Alagoz, G1
Champagne, S1
Anctil, JL1
Goyette, A1
Lajoie, C1
Des Marchais, B1
Nakamura-Shibasaki, M1
Latief, MA1
Ko, JA1
Funaishi, K1
Kiuchi, Y1
Oatts, JT1
Wang, X1
Loewen, NA1
Zhang, L1
Weizer, JS1
Musch, DC1
Besada, E1
Shechtman, D1
Frauens, BJ1
Zeraatian, S1
Zakeri, H1
Hourang, MH1
Ghaffarpasand, F1
El Chehab, H1
Le Corre, A1
Giraud, JM1
Ract-Madoux, G1
Swalduz, B1
Dot, C1
Sebastiani, A2
Parmeggiani, F1
Costagliola, C1
Ciancaglini, M1
D'Oronzo, E1
Mastropasqua, L1
Georgiou, M1
Parlapani, A1
Argiriadou, H1
Papagiannopoulou, P1
Katsikis, G1
Kaprini, E1
Kasetti, SR1
Desai, SP1
Sivakumar, S1
Sunderraj, P1
Sihota, R2
Rajashekhar, YL1
Venkatesh, P1
Agarwal, H1
Arieta, C1
Amaral, M1
Matuda, E1
Crosta, C1
de Carvalho Moreira Filho, D1
José, N1
Lin, JC1
Samuel, F1
Katz, LJ2
Spaeth, GL3
Hoop, J1
Cantor, LB1
Barnes, EA1
Murdoch, IE1
Subramaniam, S1
Cahill, A1
Kehoe, B1
Behrend, M1
Kawai, K2
Sugiyama, K4
Kitazawa, Y4
Chen, TC2
Unal, M1
Yücel, I1
Akar, Y1
Scuderi, G1
Regine, F1
Perdicchi, A1
Mannino, G1
Recupero, SM1
Kotecha, A1
Elsheikh, A1
Roberts, CR1
Zhu, H1
Garway-Heath, DF1
Lütjen-Drecoll, E1
Kruse, FE1
Weigert, G2
Resch, H2
Luksch, A1
Reitsamer, HA1
Fuchsjager-Mayrl, G2
Schmetterer, L2
Garhofer, G2
Meredith, SP1
Swift, L1
Eke, T1
Broadway, DC1
Innemee, HC8
de Jonge, A1
van Meel, JC1
Timmermans, PB1
van Zwieten, PA8
Silvestrini, B1
Bonomi, L2
Lisciani, R1
Perfetti, S1
Belluci, R1
Massa, F1
Baldini, A1
Krejcí, L1
Brozek, B1
Hermans, AJ2
Chiou, GC1
Lee, DA1
Topper, JE1
Brubaker, RF6
Chang, FW2
Potter, DE3
Shen, ZM1
Balacco-Gabrieli, C1
Salamanna, S1
Giuliani, E1
Mastrandrea, G1
Latorre, M1
Kaskel, D1
Becker, H1
Rudolf, H1
Hodapp, E1
Kolker, AE3
Kass, MA1
Goldberg, I1
Becker, B1
Gordon, M1
Rozsíval, P1
Hrochovà, J1
Rehák, S1
Rowland, JM1
Junker, C1
Junker, H1
Feibel, RM1
Bömer, TG2
Lagrèze, WD2
Funk, J2
Robin, AL20
Ritch, R4
Shin, DH6
Smythe, B2
Mundorf, T2
Lehmann, RP3
Gabelt, BT1
Robinson, JC1
Hubbard, WC1
Peterson, CM1
Debink, N1
Wadhwa, A1
Kaufman, PL2
Gramer, E1
Busche, S1
Kampik, A1
Parsons, D1
Feist, RM1
Palmer, DJ1
Fiscella, R1
Ernest, JT1
Tripathi, R1
Torczynski, E1
Farber, M1
Stewart, WC5
Shrader, CE1
van Buskirk, EM2
Butler, P1
Mannschreck, M1
Lin, S1
Hwang, I1
Alvarado, J1
Toris, CB1
Tafoya, ME1
Camras, CB3
Yablonski, ME1
Hong, C2
Song, KY2
Cullom, RD1
Schwartz, LW1
Dapling, RB1
Cunliffe, IA1
Longstaff, S1
Groh, MJ1
Michelson, G1
Groh, ME1
Gründler, AE1
Muthusamy, P1
Alimgil, ML1
Erda, S1
Benian, O1
Araie, M1
Ishi, K1
Pfeiffer, N2
Filos, KS1
Patroni, O1
Goudas, LC1
Bosas, O1
Kassaras, A1
Gartaganis, S1
Nagasubramanian, S1
Hitchings, RA1
Demailly, P1
Chuniaud, M1
Pannarale, MR1
Pecori-Giraldi, J1
Stodtmeister, R2
Parsons, DG1
Hynie, S2
Cepelík, J2
Polarz, H1
Böhrer, H1
Martin, E1
Wolfrum, J1
Völcker, HE1
Bellucci, R1
Pagliarusco, A1
Stefani, L1
Núñez, M1
Figueira, A1
Guerra, V1
Baños, G1
Alvarez, ML1
Rodríguez, M1
Araujo, SV2
Bond, JB1
Wilson, RP1
Moster, MR1
Schmidt, CM1
Lin, SL1
Liang, SS1
Laibovitz, R1
Horwitz, B1
Stewart, RH4
Kottler, M1
Shin, D1
Miller, PE2
Nelson, MJ1
Rhaesa, SL2
Celiker, UO1
Celebi, S1
Celiker, H1
Celebi, H1
Weindler, J1
Rippa, A1
Kiefer, T1
Burg, A1
Ruprecht, KW1
Azuara-Blanco, A1
Lu, DW1
Lesk, MR2
Threlkeld, AB1
Assalian, AA1
Allingham, RR1
Shields, MB3
Agarwal, HC1
Rajashekar, YL1
Drake, MV1
Rosenberg, LF2
Krupin, T2
Ruderman, J1
McDaniel, DL1
Siegfried, C1
Karalekas, DP1
Grewal, RK1
Gieser, DK1
Williams, R1
Gross, RL1
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Chung, HS2
Birt, CM2
Kim, C3
Lee, D1
Levin, DS1
Hakimzadeh, R1
Juzych, MS2
Yüksel, N2
Elibol, O2
Caglar, Y2
Alçelik, T1
Garrison, PM1
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Kim, DM1
Morrison, JC3
Nylander, KB1
Lauer, AK1
Cepurna, WO1
Johnson, E1
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Lee, MS1
Pasha, M1
Weitzman, M1
Sterk, CC1
Renzenbrink-Bubberman, AC1
van Best, JA1
Burnstein, Y2
Shelton, K1
Higginbotham, EJ2
Caicedo, M1
Dedina, M1
Dinslage, S1
McLaren, J1
Brubaker, R1
Byrd, S1
Singh, K1
Schadlu, R1
Maus, TL2
Nau, CB1
Lewis, R1
Perkins, TW1
Gangnon, R1
Heatley, GA1
Lo Presti, L1
Morgese, A1
Ravot, M1
Brogliatti, B1
Boles Carenini, B1
Searles, RV1
Shikher, V1
Balaban, CD1
Severs, WB1
Gebhardt, DO1
Chevrier, RL1
Assalian, A1
Duperré, J1
Nau, C1
Kaufman, PF1
Glover, BK2
Cha, SC1
Kim, YY1
Nguyen, KD1
Ren, J1
Hughes, BA1
Nishimoto, JH1
Tang, IH1
Kolin, T1
Barnes, SD1
Campagna, JA1
Dirks, MS1
Doe, EA1
Zeki, SM1
Konstas, AG1
Maltezos, A1
Mantziris, DA1
Sine, CS1
Apătăchioae, I1
Chiseliţă, D1
Chakraborty, P1
Villada, JR1
Tinu, A1
Sharma, S1
Cheung, J1
Mittra, RA1
Pollack, JS1
Dev, S1
Han, DP1
Mieler, WF1
Pulido, JS2
Connor, TB1
Geyer, O2
Schmidt, KG1
Pianka, P1
Neudorfer, M1
Lazar, M2
Lacheretz, F1
Barbier, A1
Serradeil-Le Gal, C1
Elena, PP1
Maffrand, JP1
Le Fur, G1
Beilin, M1
Neumann, R1
Belkin, M1
Green, K1
Bar-Ilan, A1
Morales, J1
Brown, SM1
Abdul-Rahim, AS1
Crosson, CE1
Oruç, S1
Sener, EC1
Lai, JS1
Tham, CC1
Chua, JK1
Lam, DS1
Kuba, GB1
Austermann, P1
Ang, RT1
Grosskreutz, CL1
Pasquale, LR1
Fan, JT1
Zhao, J1
Mao, J1
Liu, X1
Stîngu, C1
Cristescu, A1
Dărăban, C1
Ioniţă, M1
Serghiescu, S1
Bunin, AJ1
Jakovlev, AA1
Jermakova, VN1
Konde, LA1
Allen, RC1
Langham, ME2
Krieglstein, GK1
Leydhecker, W1
Ralli, R1
van Ommeren, JD1
Stiegler, G1
Tittarelli, R2
Pirani, A1
Casini, E1
Palmerini, S1
Valazzi, CM1
Macri, FJ1
Cevario, SJ1
Conrads, H1
Busse, H1
Jünemann, G2
Lienert, F1
Sayegh, F3
Bill, A1
Heilmann, K8
Marquardt, R3
Merté, HJ1
Harrison, R1
Kaufmann, CS1
Szymański, A1
Brozyna-Zyłka, B1
Sobieraj, A1
Otrzonsek, D1
Vocci, MJ1
Wahl, JC1
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Masaoka, Y2
Ueda, T3
Koide, R3
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Uchida, E3
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McCarty, GR1
deFaller, JM4
Burk, LL1
Holmwood, PC1
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Brodstein, DE1
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Goldenfeld, M1
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Jin, Y1
Verstappen, A1
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Arkin, LM1
Koskela, T1
Yaldo, MK1
Parrow, KA1
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Heuer, DK1
Baerveldt, G1
Martone, JF1
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Varssano, D1
Ming, YZ1
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Fernandez-Bahamonde, JL1
Alcaraz-Michelli, V1
King, MH1
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Pollack, IP7
Rudikoff, MT1
Mayer, PR1
Tost, M1
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Clinical Trials (3)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Short-term Intraocular Pressure Control After YAG Iridotomy - Comparison Between Brimonidine 0.1% vs. 0.2%[NCT01417858]50 participants (Anticipated)Interventional2010-11-30Recruiting
Central Corneal Thickness and 24-hour Fluctuation of Intraocular Pressure[NCT00941525]Phase 4174 participants (Actual)Interventional2009-09-30Completed
A Prospective, Randomized Study Comparing the Effects of Topical Aqueous Suppressants on Intraocular Gas Duration Following Pars Plana Vitrectomy[NCT01257698]21 participants (Actual)Interventional2010-02-28Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Duration of Intraocular Gas

Patients will self-monitor gas bubble duration and will receive weekly phone calls by the study coordinator until gas disappearance is confirmed. (NCT01257698)
Timeframe: Up to 4 weeks

Interventiondays (Mean)
Dorzolamide-timolol Topical Drops17.1
Standard of Care18.1

Reviews

13 reviews available for clonidine and Intraocular Pressure

ArticleYear
Perioperative medications for preventing temporarily increased intraocular pressure after laser trabeculoplasty.
    The Cochrane database of systematic reviews, 2017, 02-23, Volume: 2

    Topics: Adrenergic alpha-2 Receptor Agonists; Antihypertensive Agents; Brimonidine Tartrate; Clonidine; Conj

2017
[Primary open angle glaucoma. Morphological bases for the understanding of the pathogenesis and effects of antiglaucomatic substances].
    Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft, 2007, Volume: 104, Issue:2

    Topics: Adrenergic alpha-Agonists; Adrenergic beta-Antagonists; Age Factors; Aqueous Humor; Carbonic Anhydra

2007
Questions concerning the role of apraclonidine in the management of glaucoma.
    Archives of ophthalmology (Chicago, Ill. : 1960), 1995, Volume: 113, Issue:6

    Topics: Adrenergic alpha-Agonists; Clonidine; Glaucoma, Open-Angle; Humans; Intraocular Pressure; Ocular Hyp

1995
[Review of glaucoma research].
    Klinische Monatsblatter fur Augenheilkunde, 1993, Volume: 203, Issue:1

    Topics: Adrenergic alpha-Agonists; Carbonic Anhydrase Inhibitors; Clonidine; Glaucoma; Humans; Intraocular P

1993
New medical therapies for glaucoma.
    International ophthalmology clinics, 1996,Spring, Volume: 36, Issue:2

    Topics: Adrenergic alpha-Agonists; Carbonic Anhydrase Inhibitors; Clonidine; Glaucoma, Open-Angle; Humans; I

1996
[Effect and side effects of apraclonidine].
    Klinische Monatsblatter fur Augenheilkunde, 1996, Volume: 209, Issue:1

    Topics: Adrenergic alpha-Agonists; Clonidine; Drug Therapy, Combination; Glaucoma; Humans; Intraocular Press

1996
Beta-blocker-induced complications and the patient with glaucoma. Newer treatments to help reduce systemic adverse events.
    Archives of internal medicine, 1998, Feb-09, Volume: 158, Issue:3

    Topics: Adrenergic beta-Antagonists; Brimonidine Tartrate; Cardiovascular System; Central Nervous System; Cl

1998
Selectivity of site of action and systemic effects of topical alpha agonists.
    Current opinion in ophthalmology, 1998, Volume: 9, Issue:2

    Topics: Administration, Topical; Adrenergic alpha-Agonists; Animals; Brimonidine Tartrate; Clonidine; Glauco

1998
Assessment of ocular hypotensive mechanisms and additivity of antiglaucoma drugs in humans.
    Archives of ophthalmology (Chicago, Ill. : 1960), 1999, Volume: 117, Issue:5

    Topics: Administration, Topical; Adrenergic alpha-Agonists; Aqueous Humor; Brimonidine Tartrate; Clonidine;

1999
[Alpha-2 adrenergic agonists in the treatment of glaucoma].
    Oftalmologia (Bucharest, Romania : 1990), 1999, Volume: 47, Issue:2

    Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-Agonists; Brimonidine Tartrate; Clonidine; Gl

1999
[New developments in drug therapy of glaucoma].
    Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft, 1992, Volume: 89, Issue:1

    Topics: Adrenergic alpha-Agonists; Carbonic Anhydrase Inhibitors; Clonidine; Glaucoma; Humans; Intraocular P

1992
[Pharmacology aspects of glaucoma].
    Nordisk medicin, 1992, Volume: 107, Issue:12

    Topics: Adrenergic alpha-Agonists; Adrenergic beta-Antagonists; Calcium Channel Blockers; Carbonic Anhydrase

1992
Medical management of acute postoperative intraocular pressure rises associated with anterior segment ophthalmic laser surgery.
    International ophthalmology clinics, 1990,Spring, Volume: 30, Issue:2

    Topics: Anterior Eye Segment; Clonidine; Glaucoma; Humans; Intraocular Pressure; Iris; Laser Therapy; Trabec

1990

Trials

101 trials available for clonidine and Intraocular Pressure

ArticleYear
Effect of Topically Applied 0.5% Apraclonidine Versus 0.5% Timolol Maleate on Intraocular Pressure of Healthy Horses.
    Journal of equine veterinary science, 2022, Volume: 111

    Topics: Adrenergic alpha-Agonists; Animals; Clonidine; Double-Blind Method; Female; Horse Diseases; Horses;

2022
Effect of Apraclonidine and Diclofenac on Early Changes in Intraocular Pressure After Selective Laser Trabeculoplasty.
    Journal of glaucoma, 2020, Volume: 29, Issue:4

    Topics: Adrenergic alpha-2 Receptor Agonists; Aged; Anti-Inflammatory Agents, Non-Steroidal; Clonidine; Dicl

2020
Effect of oral clonidine on acute intraocular pressure rise after cataract extraction under general anaesthesia.
    JPMA. The Journal of the Pakistan Medical Association, 2012, Volume: 62, Issue:12

    Topics: Administration, Oral; Aged; Analysis of Variance; Anesthesia, General; Antihypertensive Agents; Cata

2012
Short-term effect of topical brinzolamide 1%-timolol 0.5% fixed combination on human central corneal thickness.
    Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics, 2015, Volume: 31, Issue:4

    Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic beta-Antagonists; Aged; Capsule Opacification; Carb

2015
Influence on intraocular pressure of anti-inflammatory treatments after selective laser trabeculoplasty.
    Journal francais d'ophtalmologie, 2015, Volume: 38, Issue:7

    Topics: Aged; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Clonidine; Combined Modalit

2015
Effect of alpha-2-agonist premedication on intraocular pressure after selective laser trabeculoplasty.
    Indian journal of ophthalmology, 2015, Volume: 63, Issue:12

    Topics: Adrenergic alpha-2 Receptor Agonists; Aged; Brimonidine Tartrate; Clonidine; Female; Glaucoma, Open-

2015
Effect of oral clonidine on acute intraocular pressure rise after phacoemulsification: a prospective double-blind, randomized, clinical trial.
    Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics, 2011, Volume: 27, Issue:3

    Topics: Acute Disease; Administration, Oral; Adrenergic alpha-2 Receptor Agonists; Aged; Clonidine; Double-B

2011
[Efficacy of prophylactic treatment of intraocular pressure spikes due to intravitreal injections].
    Journal francais d'ophtalmologie, 2012, Volume: 35, Issue:8

    Topics: Acetazolamide; Aged; Antibodies, Monoclonal, Humanized; Antihypertensive Agents; Bevacizumab; Brimon

2012
Effects of acute topical administration of clonidine 0.125%, apraclonidine 1.0% and brimonidine 0.2% on visual field parameters and ocular perfusion pressure in patients with primary open-angle glaucoma.
    Acta ophthalmologica Scandinavica. Supplement, 2002, Volume: 236

    Topics: Administration, Topical; Adrenergic alpha-Agonists; Aged; Blood Pressure; Brimonidine Tartrate; Clon

2002
Sufentanil or clonidine for blunting the increase in intraocular pressure during rapid-sequence induction.
    European journal of anaesthesiology, 2002, Volume: 19, Issue:11

    Topics: Adrenergic alpha-Agonists; Analgesics; Analgesics, Opioid; Anesthesia, General; Clonidine; Double-Bl

2002
Preventing intraocular pressure increase after phacoemulsification and the role of perioperative apraclonidine.
    Journal of cataract and refractive surgery, 2002, Volume: 28, Issue:12

    Topics: Administration, Topical; Adrenergic alpha-Agonists; Aged; Aged, 80 and over; Clonidine; Double-Blind

2002
A prospective, long-term, randomized study of the efficacy and safety of the drug combination pilocarpine 1% with clonidine 0.06% or clonidine 0.125% versus timolol 0.25%.
    Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics, 2002, Volume: 18, Issue:6

    Topics: Adrenergic alpha-Agonists; Adrenergic beta-Antagonists; Clonidine; Drug Administration Schedule; Dru

2002
Dorzolamide X apraclonidine in the prevention of the intraocular pressure spike after Nd : YAG laser posterior capsulotomy.
    Current eye research, 2002, Volume: 25, Issue:4

    Topics: Adrenergic alpha-Agonists; Adult; Aged; Aged, 80 and over; Carbonic Anhydrase Inhibitors; Clonidine;

2002
The effect of topical glaucoma medications evaluated by perimetry.
    The British journal of ophthalmology, 2003, Volume: 87, Issue:6

    Topics: Administration, Topical; Antihypertensive Agents; Betaxolol; Clonidine; Epinephrine; Glaucoma; Human

2003
Neodymium:yttrium-aluminum-garnet capsulotomy and intraocular pressure in pseudophakic patients with glaucoma.
    Ophthalmology, 2004, Volume: 111, Issue:7

    Topics: Acetazolamide; Administration, Oral; Administration, Topical; Adrenergic alpha-Agonists; Antihyperte

2004
Brimonidine 0.15% versus apraclonidine 0.5% for prevention of intraocular pressure elevation after anterior segment laser surgery.
    Journal of cataract and refractive surgery, 2005, Volume: 31, Issue:9

    Topics: Adrenergic alpha-Agonists; Aged; Anterior Eye Segment; Antihypertensive Agents; Blood Pressure; Brim

2005
Brinzolamide 1% versus apraclonidine 0.5% to prevent intraocular pressure elevation after neodymium:YAG laser posterior capsulotomy.
    Journal of cataract and refractive surgery, 2006, Volume: 32, Issue:9

    Topics: Adrenergic alpha-Agonists; Adult; Aged; Aged, 80 and over; Carbonic Anhydrase Inhibitors; Clonidine;

2006
Comparative efficacy of acetazolamide and apraclonidine in the control of intraocular pressure following phacoemulsification.
    Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift fur Augenheilkunde, 2006, Volume: 220, Issue:6

    Topics: Acetazolamide; Administration, Oral; Administration, Topical; Adrenergic alpha-Agonists; Aged; Aged,

2006
Intravenous administration of clonidine reduces intraocular pressure and alters ocular blood flow.
    The British journal of ophthalmology, 2007, Volume: 91, Issue:10

    Topics: Adrenergic alpha-Agonists; Blood Pressure; Choroid; Clonidine; Cross-Over Studies; Double-Blind Meth

2007
Effects of topical clonidine versus brimonidine on choroidal blood flow and intraocular pressure during squatting.
    Investigative ophthalmology & visual science, 2007, Volume: 48, Issue:9

    Topics: Administration, Topical; Adrenergic alpha-Agonists; Adult; Blood Flow Velocity; Brimonidine Tartrate

2007
Effect of clonidine on aqueous humor flow in normal human eyes.
    Experimental eye research, 1984, Volume: 38, Issue:3

    Topics: Administration, Topical; Aqueous Humor; Clinical Trials as Topic; Clonidine; Double-Blind Method; Fe

1984
The effect of topical clonidine on intraocular pressure.
    Archives of ophthalmology (Chicago, Ill. : 1960), 1981, Volume: 99, Issue:7

    Topics: Adult; Aged; Clinical Trials as Topic; Clonidine; Double-Blind Method; Female; Glaucoma; Humans; Int

1981
Intraocular pressure rise after phacoemulsification with posterior chamber lens implantation: effect of prophylactic medication, wound closure, and surgeon's experience.
    The British journal of ophthalmology, 1995, Volume: 79, Issue:9

    Topics: Acetazolamide; Adrenergic alpha-Antagonists; Aged; Clonidine; Female; Humans; Intraocular Pressure;

1995
Short-term efficacy of apraclonidine hydrochloride added to maximum-tolerated medical therapy for glaucoma. Apraclonidine Maximum-Tolerated Medical Therapy Study Group.
    American journal of ophthalmology, 1995, Volume: 120, Issue:4

    Topics: Adrenergic alpha-Agonists; Adrenergic beta-Antagonists; Adult; Aged; Aged, 80 and over; Carbonic Anh

1995
Effectiveness of apraclonidine and acetazolamide in preventing postoperative intraocular pressure spikes after extracapsular cataract extraction.
    Journal of cataract and refractive surgery, 1995, Volume: 21, Issue:2

    Topics: Acetazolamide; Administration, Oral; Administration, Topical; Adrenergic alpha-Agonists; Aged; Catar

1995
The efficacy of apraclonidine as an adjunct to timolol therapy. Apraclonidine Adjunctive Therapy Study Group.
    Archives of ophthalmology (Chicago, Ill. : 1960), 1995, Volume: 113, Issue:3

    Topics: Adrenergic alpha-Agonists; Chemotherapy, Adjuvant; Clonidine; Double-Blind Method; Drug Administrati

1995
Effects of apraclonidine on aqueous humor dynamics in human eyes.
    Ophthalmology, 1995, Volume: 102, Issue:3

    Topics: Adrenergic alpha-Agonists; Adult; Aged; Anterior Eye Segment; Aqueous Humor; Clonidine; Double-Blind

1995
[Increased intraocular pressure after cataract extraction--effect of surgical technique, surgical procedure and preventive drug administration. A prospective, randomized double-blind study].
    Klinische Monatsblatter fur Augenheilkunde, 1995, Volume: 206, Issue:1

    Topics: Acetazolamide; Adrenergic alpha-Agonists; Aged; Aged, 80 and over; Cataract Extraction; Clinical Com

1995
Influence of apraclonidine and pilocarpine alone and in combination on post laser trabeculoplasty pressure rise.
    The British journal of ophthalmology, 1994, Volume: 78, Issue:1

    Topics: Adrenergic beta-Agonists; Aged; Aged, 80 and over; Blood Pressure; Clonidine; Glaucoma, Open-Angle;

1994
Ocular macro- and microcirculation after topical application of clonidine and metipranolol.
    German journal of ophthalmology, 1994, Volume: 3, Issue:3

    Topics: Administration, Topical; Adult; Blood Flow Velocity; Clonidine; Hemodynamics; Humans; Intraocular Pr

1994
[The additive effect of dipivefrin in patients with wide angle glaucoma treated with long-term beta-blocker therapy in comparison with clonidine].
    Klinische Monatsblatter fur Augenheilkunde, 1994, Volume: 205, Issue:2

    Topics: Clonidine; Drug Synergism; Drug Therapy, Combination; Epinephrine; Female; Glaucoma, Open-Angle; Hum

1994
Effect of topical apraclonidine on the frequency of intraocular pressure elevations after combined extracapsular cataract extraction and trabeculectomy.
    Ophthalmology, 1993, Volume: 100, Issue:5

    Topics: Adrenergic alpha-Agonists; Aged; Cataract Extraction; Clonidine; Double-Blind Method; Female; Glauco

1993
Effects of apraclonidine on intraocular pressure and blood-aqueous barrier permeability after phacoemulsification and intraocular lens implantation.
    American journal of ophthalmology, 1993, Jul-15, Volume: 116, Issue:1

    Topics: Adrenergic alpha-Agonists; Aged; Aqueous Humor; Blood; Cataract Extraction; Cell Membrane Permeabili

1993
A dose-response study of orally administered clonidine as premedication in the elderly: evaluating hemodynamic safety.
    Anesthesia and analgesia, 1993, Volume: 77, Issue:6

    Topics: Administration, Oral; Aged; Aged, 80 and over; Anesthesia, Local; Clonidine; Dose-Response Relations

1993
Comparison of apraclonidine and timolol in chronic open-angle glaucoma. A three-month study.
    Ophthalmology, 1993, Volume: 100, Issue:9

    Topics: Adult; Aged; Aged, 80 and over; Chronic Disease; Clonidine; Double-Blind Method; Drug Administration

1993
Oral clonidine premedication prevents the rise in intraocular pressure following succinylcholine administration.
    German journal of ophthalmology, 1993, Volume: 2, Issue:2

    Topics: Administration, Oral; Aged; Blood Pressure; Clonidine; Clorazepate Dipotassium; Double-Blind Method;

1993
[Comparative study of clonidine and lidocaine on the attenuation of the intraocular pressure increase associated with laryngoscopy and endotracheal intubation].
    Revista espanola de anestesiologia y reanimacion, 1995, Volume: 42, Issue:8

    Topics: Adult; Aged; Blood Pressure; Clonidine; Double-Blind Method; Female; Heart Rate; Humans; Intraocular

1995
A 90-day study of the efficacy and side effects of 0.25% and 0.5% apraclonidine vs 0.5% timolol. Apraclonidine Primary Therapy Study Group.
    Archives of ophthalmology (Chicago, Ill. : 1960), 1996, Volume: 114, Issue:8

    Topics: Administration, Topical; Adrenergic alpha-Agonists; Adrenergic beta-Antagonists; Clonidine; Double-B

1996
Topical apraclonidine hydrochloride in eyes with poorly controlled glaucoma. The Apraclonidine Maximum Tolerated Medical Therapy Study Group.
    Transactions of the American Ophthalmological Society, 1995, Volume: 93

    Topics: Administration, Topical; Adrenergic alpha-Agonists; Adult; Aged; Aged, 80 and over; Clonidine; Doubl

1995
[0.15 mg clonidine as oral premedication in retrobulbar anesthesia].
    Klinische Monatsblatter fur Augenheilkunde, 1996, Volume: 208, Issue:5

    Topics: Administration, Oral; Adrenergic alpha-Agonists; Aged; Anesthesia, Local; Blood Pressure; Cataract E

1996
Apraclonidine 0.5% versus 1% for controlling intraocular pressure elevation after argon laser trabeculoplasty.
    Ophthalmic surgery and lasers, 1996, Volume: 27, Issue:8

    Topics: Administration, Topical; Adrenergic alpha-Agonists; Clonidine; Follow-Up Studies; Glaucoma; Humans;

1996
A comparative evaluation of pilocarpine 1% and clonidine 0.125% versus timolol 0.5%.
    Indian journal of ophthalmology, 1996, Volume: 44, Issue:2

    Topics: Administration, Topical; Adrenergic alpha-Agonists; Adrenergic beta-Antagonists; Adult; Blood Pressu

1996
Apraclonidine and anterior segment laser surgery. Comparison of 0.5% versus 1.0% apraclonidine for prevention of postoperative intraocular pressure rise.
    Ophthalmology, 1995, Volume: 102, Issue:9

    Topics: Adrenergic alpha-Agonists; Aged; Anterior Eye Segment; Clonidine; Double-Blind Method; Glaucoma; Hum

1995
Short-term effect of apraclonidine on intraocular pressure in glaucoma patients receiving timolol and pilocarpine.
    Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift fur Augenheilkunde, 1997, Volume: 211, Issue:6

    Topics: Administration, Topical; Adrenergic alpha-Agonists; Adrenergic beta-Antagonists; Aged; Clonidine; Dr

1997
Effects of 0.5% apraclonidine on optic nerve head and peripapillary retinal blood flow.
    The British journal of ophthalmology, 1997, Volume: 81, Issue:12

    Topics: Adrenergic alpha-Agonists; Adult; Clonidine; Double-Blind Method; Female; Hemodynamics; Humans; Intr

1997
Short-term clinical trial evaluating the efficacy of the combination of apraclonidine 0.5% solution and betaxolol 0.25% suspension.
    Acta ophthalmologica Scandinavica. Supplement, 1997, Issue:224

    Topics: Adolescent; Adrenergic alpha-Agonists; Adrenergic beta-Antagonists; Adult; Aged; Betaxolol; Chronic

1997
The effect of 1% apraclonidine on intraocular pressure after cataract surgery.
    Ophthalmic surgery and lasers, 1998, Volume: 29, Issue:6

    Topics: Administration, Topical; Adolescent; Adrenergic alpha-Agonists; Cataract Extraction; Clonidine; Doub

1998
Medical control of intraocular pressure after cataract surgery.
    Journal of cataract and refractive surgery, 1998, Volume: 24, Issue:11

    Topics: Acetazolamide; Administration, Oral; Administration, Topical; Adrenergic alpha-Agonists; Aged; Carbo

1998
Comparison of the efficacy of apraclonidine and brimonidine as aqueous suppressants in humans.
    Archives of ophthalmology (Chicago, Ill. : 1960), 1998, Volume: 116, Issue:11

    Topics: Adrenergic alpha-Agonists; Adult; Aqueous Humor; Brimonidine Tartrate; Clonidine; Female; Fluorophot

1998
Apraclonidine 0.5% versus brimonidine 0.2% for the control of intraocular pressure elevation following anterior segment laser procedures.
    Ophthalmic surgery and lasers, 1999, Volume: 30, Issue:3

    Topics: Adrenergic alpha-Agonists; Adult; Aged; Aged, 80 and over; Anterior Eye Segment; Brimonidine Tartrat

1999
Comparison of the early effects of brimonidine and apraclonidine as topical ocular hypotensive agents.
    Archives of ophthalmology (Chicago, Ill. : 1960), 1999, Volume: 117, Issue:5

    Topics: Administration, Topical; Adrenergic alpha-Agonists; Antihypertensive Agents; Aqueous Humor; Brimonid

1999
Long-term brimonidine therapy in glaucoma patients with apraclonidine allergy.
    American journal of ophthalmology, 1999, Volume: 127, Issue:5

    Topics: Adrenergic alpha-Agonists; Aged; Brimonidine Tartrate; Chronic Disease; Clonidine; Drug Hypersensiti

1999
Efficacy of apraclonidine 1% versus pilocarpine 4% for prophylaxis of intraocular pressure spike after argon laser trabeculoplasty.
    Ophthalmology, 1999, Volume: 106, Issue:6

    Topics: Aged; Clonidine; Female; Glaucoma, Open-Angle; Humans; Incidence; Intraocular Pressure; Laser Therap

1999
Reversal of intraocular pressure increases with 0.5% apraclonidine after dilated fundus examination in patients with chronic open-angle glaucoma.
    Journal of the American Optometric Association, 1999, Volume: 70, Issue:4

    Topics: Adrenergic alpha-Agonists; Aged; Aged, 80 and over; Chronic Disease; Clonidine; Double-Blind Method;

1999
Control of intraocular pressure elevations after argon laser trabeculoplasty: comparison of brimonidine 0.2% to apraclonidine 1.0%.
    Ophthalmology, 1999, Volume: 106, Issue:10

    Topics: Adrenergic alpha-Agonists; Aged; Brimonidine Tartrate; Clonidine; Double-Blind Method; Female; Glauc

1999
The comparative ocular hypotensive effect of apraclonidine with timolol maleate in exfoliation versus primary open-angle glaucoma patients.
    Eye (London, England), 1999, Volume: 13 ( Pt 3a)

    Topics: Adrenergic alpha-Agonists; Adrenergic beta-Antagonists; Aged; Circadian Rhythm; Clonidine; Drug Ther

1999
The use of topical aqueous suppressants in the prevention of postoperative intraocular pressure elevation after pars plana vitrectomy with long-acting gas tamponade.
    Ophthalmology, 2000, Volume: 107, Issue:3

    Topics: Administration, Topical; Antihypertensive Agents; Aqueous Humor; Brimonidine Tartrate; Clonidine; Fl

2000
A comparative study on the effects of apraclonidine and timolol on the ophthalmic blood flow velocity waveforms.
    International ophthalmology, 1999, Volume: 23, Issue:2

    Topics: Adrenergic alpha-Agonists; Adrenergic beta-Antagonists; Adult; Blood Flow Velocity; Blood Pressure;

1999
[Reduction of ocular pulse amplitude by apraclonidine--prospective double-blind, randomized clinical trial with 10 subjects].
    Klinische Monatsblatter fur Augenheilkunde, 2001, Volume: 218, Issue:3

    Topics: Administration, Topical; Adrenergic alpha-Agonists; Adult; Clonidine; Double-Blind Method; Female; G

2001
Brimonidine 0.2% versus apraclonidine 0.5% for prevention of intraocular pressure elevations after anterior segment laser surgery.
    Ophthalmology, 2001, Volume: 108, Issue:6

    Topics: Adrenergic alpha-Agonists; Aged; Anterior Eye Segment; Blood Pressure; Brimonidine Tartrate; Clonidi

2001
[Apraclonidine prevents the acute increase of intraocular pressure in brown eyes with Nd:YAG laser iridectomy].
    [Zhonghua yan ke za zhi] Chinese journal of ophthalmology, 1998, Volume: 34, Issue:3

    Topics: Clonidine; Female; Humans; Intraocular Pressure; Iridectomy; Laser Therapy; Male; Ocular Hypertensio

1998
[Observations on the treatment of glaucoma with clonidin (author's transl)].
    Klinische Monatsblatter fur Augenheilkunde, 1976, Volume: 168, Issue:6

    Topics: Adult; Clinical Trials as Topic; Clonidine; Drug Evaluation; Fatigue; Glaucoma; Humans; Intraocular

1976
[Clonidine as ointment (author's transl)].
    Klinische Monatsblatter fur Augenheilkunde, 1976, Volume: 168, Issue:6

    Topics: Adult; Aged; Chronic Disease; Clinical Trials as Topic; Clonidine; Drug Evaluation; Female; Glaucoma

1976
Clonidine. Effects of a topically administered solution on intraocular pressure and blood pressure in open-angle glaucoma.
    Archives of ophthalmology (Chicago, Ill. : 1960), 1977, Volume: 95, Issue:8

    Topics: Administration, Topical; Blood Pressure; Clonidine; Glaucoma; Humans; Intraocular Pressure; Pilocarp

1977
[Various clonidine drops in treatment of glaucoma].
    Klinika oczna, 1992, Volume: 94, Issue:10

    Topics: Aged; Clonidine; Double-Blind Method; Female; Glaucoma; Humans; Intraocular Pressure; Male; Middle A

1992
Reformulation and drop size of apraclonidine hydrochloride.
    American journal of ophthalmology, 1992, Feb-15, Volume: 113, Issue:2

    Topics: Adrenergic alpha-Agonists; Adult; Clonidine; Double-Blind Method; Female; Formularies as Topic; Huma

1992
Prophylactic use of apraclonidine for intraocular pressure increase after Nd:YAG capsulotomies.
    American journal of ophthalmology, 1992, Apr-15, Volume: 113, Issue:4

    Topics: Adrenergic alpha-Agonists; Aged; Cataract Extraction; Clonidine; Double-Blind Method; Female; Humans

1992
Apraclonidine and argon laser trabeculoplasty.
    American journal of ophthalmology, 1992, Jul-15, Volume: 114, Issue:1

    Topics: Administration, Topical; Adrenergic alpha-Agonists; Clonidine; Glaucoma, Open-Angle; Humans; Intraoc

1992
Apraclonidine and early postoperative intraocular hypertension after cataract extraction.
    Acta ophthalmologica, 1992, Volume: 70, Issue:4

    Topics: Adrenergic alpha-Agonists; Cataract Extraction; Clonidine; Female; Humans; Intraocular Pressure; Len

1992
Apraclonidine and clonidine: a comparison of efficacy and side effects in normal and ocular hypertensive volunteers.
    International ophthalmology, 1992, Volume: 16, Issue:4-5

    Topics: Adrenergic beta-Agonists; Adult; Aged; Clonidine; Double-Blind Method; Female; Humans; Intraocular P

1992
Oral clonidine premedication for elderly patients undergoing intraocular surgery.
    Acta anaesthesiologica Scandinavica, 1992, Volume: 36, Issue:2

    Topics: Administration, Oral; Aged; Anesthesia Recovery Period; Cataract Extraction; Clonidine; Diazepam; Do

1992
Effect of flurbiprofen on the reduction of intraocular pressure after administration of 1% apraclonidine in patients with glaucoma.
    Archives of ophthalmology (Chicago, Ill. : 1960), 1992, Volume: 110, Issue:5

    Topics: Clonidine; Flurbiprofen; Glaucoma; Humans; Intraocular Pressure; Osmolar Concentration

1992
Effects of topical flurbiprofen on the intraocular pressure lowering effects of apraclonidine and timolol.
    Archives of ophthalmology (Chicago, Ill. : 1960), 1991, Volume: 109, Issue:6

    Topics: Administration, Topical; Adrenergic alpha-Agonists; Adult; Clonidine; Double-Blind Method; Evaluatio

1991
Apraclonidine and timolol. Combined effects in previously untreated normal subjects.
    Archives of ophthalmology (Chicago, Ill. : 1960), 1991, Volume: 109, Issue:6

    Topics: Administration, Topical; Adrenergic alpha-Agonists; Aqueous Humor; Circadian Rhythm; Clonidine; Drug

1991
Additive effect of 1% apraclonidine hydrochloride to nonselective beta-blockers.
    Ophthalmology, 1991, Volume: 98, Issue:7

    Topics: Adrenergic alpha-Agonists; Clonidine; Double-Blind Method; Drug Synergism; Female; Glaucoma, Open-An

1991
Apraclonidine prophylaxis for postcycloplegic intraocular pressure spikes.
    Ophthalmology, 1991, Volume: 98, Issue:7

    Topics: Adrenergic alpha-Agonists; Clonidine; Double-Blind Method; Glaucoma, Open-Angle; Humans; Incidence;

1991
Effect of apraclonidine hydrochloride on acute introacular pressure rise after argon laser iridotomy.
    Korean journal of ophthalmology : KJO, 1991, Volume: 5, Issue:1

    Topics: Acute Disease; Adrenergic alpha-Agonists; Adult; Aged; Clonidine; Double-Blind Method; Female; Glauc

1991
Effect of apraclonidine in long-term timolol users.
    Ophthalmology, 1991, Volume: 98, Issue:10

    Topics: Adrenergic alpha-Agonists; Aged; Aqueous Humor; Clonidine; Double-Blind Method; Drug Administration

1991
Prevention of the rise in intraocular pressure following neodymium-YAG posterior capsulotomy using topical clonidine.
    Acta ophthalmologica, 1991, Volume: 69, Issue:4

    Topics: Administration, Topical; Aged; Aged, 80 and over; Cataract Extraction; Clonidine; Female; Humans; In

1991
Apraclonidine hydrochloride: an evaluation of plasma concentrations, and a comparison of its intraocular pressure lowering and cardiovascular effects to timolol maleate.
    Transactions of the American Ophthalmological Society, 1990, Volume: 88

    Topics: Adrenergic alpha-Agonists; Adult; Blood Pressure; Clonidine; Double-Blind Method; Evaluation Studies

1990
Follicular conjunctivitis associated with apraclonidine.
    American journal of ophthalmology, 1991, Jan-15, Volume: 111, Issue:1

    Topics: Adult; Clonidine; Conjunctivitis; Glaucoma, Open-Angle; Humans; Intraocular Pressure; Male; Timolol

1991
Control of intraocular pressure with apraclonidine hydrochloride after cataract extraction.
    American journal of ophthalmology, 1991, Feb-15, Volume: 111, Issue:2

    Topics: Adult; Aged; Aged, 80 and over; Analysis of Variance; Cataract Extraction; Clonidine; Double-Blind M

1991
The combined use of apraclonidine and pilocarpine during laser iridotomy in a Hispanic population.
    Annals of ophthalmology, 1990, Volume: 22, Issue:12

    Topics: Aged; Clonidine; Double-Blind Method; Drug Therapy, Combination; Female; Glaucoma, Angle-Closure; Gl

1990
Cardiovascular and intraocular pressure effects and plasma concentrations of apraclonidine.
    Archives of ophthalmology (Chicago, Ill. : 1960), 1990, Volume: 108, Issue:9

    Topics: Administration, Topical; Adult; Analysis of Variance; Blood Pressure; Cardiovascular System; Chi-Squ

1990
Adjunctive glaucoma therapy. A comparison of apraclonidine to dipivefrin when added to timolol maleate.
    Ophthalmology, 1989, Volume: 96, Issue:1

    Topics: Adult; Aged; Clinical Trials as Topic; Clonidine; Drug Therapy, Combination; Epinephrine; Eye Diseas

1989
A limited comparison of apraclonidine's dose response in subjects with normal or increased intraocular pressure.
    American journal of ophthalmology, 1989, Sep-15, Volume: 108, Issue:3

    Topics: Adult; Aged; Circadian Rhythm; Clinical Trials as Topic; Clonidine; Dose-Response Relationship, Drug

1989
The effects of apraclonidine on conjunctival oxygen tension.
    Archives of ophthalmology (Chicago, Ill. : 1960), 1989, Volume: 107, Issue:12

    Topics: Administration, Topical; Adult; Clonidine; Conjunctiva; Female; Humans; Intraocular Pressure; Male;

1989
Efficacy and safety of apraclonidine in patients undergoing anterior segment laser surgery.
    The British journal of ophthalmology, 1989, Volume: 73, Issue:11

    Topics: Adult; Aged; Anterior Eye Segment; Blood Pressure; Clonidine; Female; Heart Rate; Humans; Intraocula

1989
"Outlier" intraocular pressure readings: valid or invalid for statistical analysis?
    Ophthalmic surgery, 1989, Volume: 20, Issue:10

    Topics: Analysis of Variance; Clinical Trials as Topic; Clonidine; Data Interpretation, Statistical; Double-

1989
Effectiveness of apraclonidine in preventing the rise in intraocular pressure after neodymium:YAG posterior capsulotomy.
    Transactions of the American Ophthalmological Society, 1988, Volume: 86

    Topics: Administration, Topical; Aged; Clonidine; Female; Glaucoma; Humans; Intraocular Pressure; Laser Ther

1988
Apraclonidine. A one-week dose-response study.
    Archives of ophthalmology (Chicago, Ill. : 1960), 1988, Volume: 106, Issue:8

    Topics: Administration, Topical; Adult; Aged; Clinical Trials as Topic; Clonidine; Dose-Response Relationshi

1988
ALO 2145 reduces the intraocular pressure elevation after anterior segment laser surgery.
    Ophthalmology, 1988, Volume: 95, Issue:3

    Topics: Aged; Anterior Eye Segment; Clinical Trials as Topic; Clonidine; Double-Blind Method; Female; Humans

1988
Aqueous flow is reduced by the alpha-adrenergic agonist, apraclonidine hydrochloride (ALO 2145).
    Ophthalmology, 1988, Volume: 95, Issue:9

    Topics: Administration, Topical; Adult; Aqueous Humor; Clonidine; Double-Blind Method; Female; Humans; Intra

1988
[Ocular hemodynamics following local administration of clonidine].
    Klinische Monatsblatter fur Augenheilkunde, 1988, Volume: 193, Issue:6

    Topics: Adult; Aged; Blood Pressure; Clinical Trials as Topic; Clonidine; Eye; Female; Glaucoma, Open-Angle;

1988
Anesthesia for ophthalmic surgery in the elderly: the effects of clonidine on intraocular pressure, perioperative hemodynamics, and anesthetic requirement.
    Anesthesiology, 1988, Volume: 68, Issue:5

    Topics: Anesthesia; Anesthesia, General; Anesthesia, Local; Animals; Clinical Trials as Topic; Clonidine; Di

1988
Effects of topical ALO 2145 (p-aminoclonidine hydrochloride) on the acute intraocular pressure rise after argon laser iridotomy.
    Archives of ophthalmology (Chicago, Ill. : 1960), 1987, Volume: 105, Issue:9

    Topics: Argon; Clonidine; Humans; Intraocular Pressure; Iris; Laser Therapy; Postoperative Period; Prospecti

1987
Prevention of the rise in intraocular pressure following neodymium-YAG posterior capsulotomy using topical 1% apraclonidine.
    Archives of ophthalmology (Chicago, Ill. : 1960), 1988, Volume: 106, Issue:6

    Topics: Administration, Topical; Aged; Cataract Extraction; Clonidine; Double-Blind Method; Female; Humans;

1988
Short-term effects of unilateral 1% apraclonidine therapy.
    Archives of ophthalmology (Chicago, Ill. : 1960), 1988, Volume: 106, Issue:7

    Topics: Administration, Topical; Adult; Circadian Rhythm; Clonidine; Drug Hypersensitivity; Eye; Eyelids; Fe

1988
[Influence of clonidine on intraocular pressure and pupillary diameter].
    Klinische Monatsblatter fur Augenheilkunde, 1972, Volume: 161, Issue:1

    Topics: Analysis of Variance; Chronic Disease; Clonidine; Glaucoma; Humans; Intraocular Pressure; Ophthalmic

1972
[Studies on the effect of Catapresan on the intraocular pressure. 3].
    Klinische Monatsblatter fur Augenheilkunde, 1972, Volume: 161, Issue:4

    Topics: Blood Pressure; Clonidine; Glaucoma; Humans; Intraocular Pressure; Ophthalmic Artery; Ophthalmodynam

1972
[Effect of clonidine on intraocular pressure and pupil diameter].
    Bucherei des Augenarztes, 1974, Volume: 63

    Topics: Clonidine; Humans; Intraocular Pressure; Pilocarpine; Placebos; Pupil

1974

Other Studies

111 other studies available for clonidine and Intraocular Pressure

ArticleYear
Synthesis and evaluation of 2-[(5-methylbenz-1-ox-4-azin-6-yl)imino]imidazoline, a potent, peripherally acting alpha 2 adrenoceptor agonist.
    Journal of medicinal chemistry, 1996, Aug-30, Volume: 39, Issue:18

    Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-Agonists; Animals; Imidazoles; Intraocular Pr

1996
[Factors influencing intraocular pressure elevation on the first postoperative day following small-incision cataract surgery--the effect of apraclonidine].
    Nippon Ganka Gakkai zasshi, 2014, Volume: 118, Issue:9

    Topics: Adrenergic alpha-2 Receptor Agonists; Aged; Cataract Extraction; Clonidine; Female; Humans; Intraocu

2014
Effects of topical adrenergic agents on prostaglandin E2-induced aqueous flare and intraocular pressure elevation in pigmented rabbits.
    Japanese journal of ophthalmology, 2016, Volume: 60, Issue:2

    Topics: Administration, Topical; Adrenergic Agonists; Animals; Aqueous Humor; Blood-Aqueous Barrier; Brimoni

2016
Recurrent serous macular detachment after topical ocular hypotensive medication.
    Clinical & experimental optometry, 2008, Volume: 91, Issue:6

    Topics: Administration, Topical; Antihypertensive Agents; Clonidine; Drug Combinations; Drug Therapy, Combin

2008
The effect of alpha2-agonist on IOP rise following Nd-YAG laser iridotomy.
    The Tokai journal of experimental and clinical medicine, 2004, Volume: 29, Issue:1

    Topics: Adrenergic alpha-Agonists; Animals; Aqueous Humor; Clonidine; Dinoprostone; Eye Proteins; Intraocula

2004
Corneal thickness- and age-related biomechanical properties of the cornea measured with the ocular response analyzer.
    Investigative ophthalmology & visual science, 2006, Volume: 47, Issue:12

    Topics: Adrenergic alpha-Agonists; Adult; Aged; Aged, 80 and over; Aging; Biomechanical Phenomena; Clonidine

2006
The acute morphologic changes that occur at the optic nerve head induced by medical reduction of intraocular pressure.
    Journal of glaucoma, 2007, Volume: 16, Issue:6

    Topics: Acetazolamide; Administration, Oral; Administration, Topical; Adrenergic alpha-Agonists; Aged; Aged,

2007
Differential effects of selective alpha 1- and alpha 2-adrenoceptor agonists on intraocular pressure in the conscious rabbit.
    Documenta ophthalmologica. Advances in ophthalmology, 1982, Jan-29, Volume: 52, Issue:3-4

    Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Azepines; Clonidine; Female; Intra

1982
Effects of dapiprazole on pupillary size and intraocular pressure in rabbits.
    Arzneimittel-Forschung, 1982, Volume: 32, Issue:6

    Topics: Administration, Topical; Adrenal Cortex Hormones; Animals; Antipsychotic Agents; Clonidine; Drug Int

1982
Influence of antiglaucoma drugs on axonal transport in the optic nerve.
    Ophthalmic research, 1983, Volume: 15, Issue:6

    Topics: Adrenergic beta-Antagonists; Animals; Axonal Transport; Clonidine; Echothiophate Iodide; Epinephrine

1983
The influence of delta 9-tetrahydrocannabinol on intraocular pressure in the anaesthetized cat.
    Documenta ophthalmologica. Advances in ophthalmology, 1980, Apr-15, Volume: 48, Issue:2

    Topics: Animals; Brain Stem; Cats; Clonidine; Dose-Response Relationship, Drug; Dronabinol; Female; Hypotens

1980
Effects of alpha 1 and alpha 2 activation of adrenergic receptors on aqueous humor dynamics.
    Life sciences, 1983, Apr-11, Volume: 32, Issue:15

    Topics: Animals; Aqueous Humor; Cats; Clonidine; Intraocular Pressure; Phenylephrine; Prazosin; Receptors, A

1983
Effects of aminotetralins on intraocular pressure and pupillary function in rabbits.
    Journal of autonomic pharmacology, 1984, Volume: 4, Issue:3

    Topics: Animals; Clonidine; Dose-Response Relationship, Drug; Intraocular Pressure; Male; Naphthalenes; Pupi

1984
[Clinical observations on reduction on intraocular pressure by clonidine solution (author's transl)].
    [Zhonghua yan ke za zhi] Chinese journal of ophthalmology, 1980, Volume: 16, Issue:1

    Topics: Adolescent; Adult; Clonidine; Female; Glaucoma; Humans; Intraocular Pressure; Male; Middle Aged

1980
[Changes in ocular tonus, pH and concentration of ascorbic acid and lactic acid in the aqueous humor of rabbits treated with clonidine].
    Bollettino della Societa italiana di biologia sperimentale, 1983, Apr-30, Volume: 59, Issue:4

    Topics: Animals; Aqueous Humor; Ascorbic Acid; Clonidine; Hydrogen-Ion Concentration; Intraocular Pressure;

1983
[Early effects of clonidine, epinephrine, and pilocarpine on the intraocular pressure and the episcleral venous pressure in normal volunteers (author's transl)].
    Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie. Albrecht von Graefe's archive for clinical and experimental ophthalmology, 1980, Volume: 213, Issue:4

    Topics: Adult; Clonidine; Epinephrine; Female; Humans; Intraocular Pressure; Male; Middle Aged; Pilocarpine;

1980
Experience with management of glaucomas by isoglaucon.
    Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift fur Augenheilkunde, 1980, Volume: 181, Issue:5

    Topics: Clonidine; Female; Glaucoma; Humans; Intraocular Pressure; Male; Middle Aged; Visual Acuity; Visual

1980
Adrenergic drugs and intraocular pressure.
    General pharmacology, 1981, Volume: 12, Issue:1

    Topics: Animals; Aqueous Humor; Clonidine; Eye; Humans; Intraocular Pressure; Rabbits; Receptors, Adrenergic

1981
[Experience with timolol in consulting patients (author's transl)].
    Klinische Monatsblatter fur Augenheilkunde, 1980, Volume: 176, Issue:5

    Topics: Clonidine; Drug Combinations; Glaucoma; Humans; Intraocular Pressure; Pilocarpine; Propanolamines; T

1980
High incidence of topical allergic reactions to 1% apraclonidine.
    Archives of ophthalmology (Chicago, Ill. : 1960), 1995, Volume: 113, Issue:12

    Topics: Administration, Topical; Adrenergic alpha-Agonists; Clonidine; Drug Hypersensitivity; Glaucoma; Huma

1995
Apraclonidine and brimonidine effects on anterior ocular and cardiovascular physiology in normal and sympathectomized monkeys.
    Experimental eye research, 1994, Volume: 59, Issue:6

    Topics: Adrenergic alpha-Agonists; Animals; Aqueous Humor; Blood Pressure; Body Weight; Brimonidine Tartrate

1994
Efficacy of apraclonidine ophthalmic solution (Iopidine) in presumed silicon oil-induced glaucoma and primary open-angle glaucoma.
    Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 1995, Volume: 233, Issue:1

    Topics: Adolescent; Adrenergic alpha-Agonists; Adult; Aged; Aged, 80 and over; Clonidine; Drug Tolerance; Fe

1995
Clinical experience with the long-term use of 1% apraclonidine. Incidence of allergic reactions.
    Archives of ophthalmology (Chicago, Ill. : 1960), 1995, Volume: 113, Issue:3

    Topics: Adrenergic alpha-Agonists; Aged; Clonidine; Drug Hypersensitivity; Female; Follow-Up Studies; Glauco

1995
Effect of apraclonidine hydrochloride on the attack of Posner-Schlossman syndrome.
    Korean journal of ophthalmology : KJO, 1993, Volume: 7, Issue:1

    Topics: Adolescent; Adrenergic alpha-Agonists; Adult; Aged; Clonidine; Female; Glaucoma, Open-Angle; Hemodyn

1993
The effect of apraclonidine on the intraocular pressure of glaucoma patients following Nd:YAG laser posterior capsulotomy.
    Ophthalmic surgery, 1993, Volume: 24, Issue:9

    Topics: Adrenergic alpha-Agonists; Aged; Clonidine; Female; Glaucoma; Humans; Incidence; Intraocular Pressur

1993
Apraclonidine in the management of glaucomatocyclitic crisis.
    Eye (London, England), 1994, Volume: 8 ( Pt 3)

    Topics: Adrenergic alpha-Agonists; Adult; Clonidine; Female; Glaucoma, Open-Angle; Humans; Intraocular Press

1994
Effects of pertussis toxin on intraocular pressure and adenylate cyclase activity of ciliary processes in rabbits.
    General physiology and biophysics, 1993, Volume: 12, Issue:2

    Topics: Adenylate Cyclase Toxin; Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Animals; Ciliary Body; Clon

1993
Apraclonidine protection of the blood-aqueous barrier from traumatic break-down.
    Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics, 1995,Spring, Volume: 11, Issue:1

    Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Aqueous Humor; Blood-Aqueous Barri

1995
Long term effect of apraclonidine.
    The British journal of ophthalmology, 1995, Volume: 79, Issue:12

    Topics: Adolescent; Adrenergic alpha-Antagonists; Adult; Aged; Aged, 80 and over; Clonidine; Female; Follow-

1995
Evaluation of adverse reactions of aponidine hydrochloride ophthalmic solution.
    Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics, 1995,Fall, Volume: 11, Issue:3

    Topics: Adrenergic alpha-Agonists; Adult; Blinking; Blood Pressure; Clonidine; Conjunctiva; Cornea; Drug Eva

1995
Effects of topical administration of 0.5% apraclonidine on intraocular pressure, pupil size, and heart rate in clinically normal dogs.
    American journal of veterinary research, 1996, Volume: 57, Issue:1

    Topics: Administration, Topical; Adrenergic alpha-Agonists; Animals; Cats; Circadian Rhythm; Clonidine; Dog

1996
Effects of topical administration of 0.5% apraclonidine on intraocular pressure, pupil size, and heart rate in clinically normal cats.
    American journal of veterinary research, 1996, Volume: 57, Issue:1

    Topics: Administration, Topical; Adrenergic alpha-Agonists; Animals; Cats; Clonidine; Dogs; Female; Heart Ra

1996
Effect of topical apraclonidine on flow properties of central retinal and ophthalmic arteries.
    Acta ophthalmologica Scandinavica, 1996, Volume: 74, Issue:2

    Topics: Administration, Topical; Adrenergic alpha-Agonists; Adult; Blood Flow Velocity; Clonidine; Female; H

1996
Effects of apraclonidine on short-term outcome of glaucoma surgery.
    Journal of glaucoma, 1996, Volume: 5, Issue:2

    Topics: Adrenergic alpha-Agonists; Aged; Clonidine; Female; Glaucoma; Humans; Intraocular Pressure; Male; Mi

1996
Clinical experience with apraclonidine 0.5%.
    Journal of glaucoma, 1997, Volume: 6, Issue:5

    Topics: Adolescent; Adrenergic alpha-Agonists; Adult; Aged; Aged, 80 and over; Child; Chronic Disease; Cloni

1997
Chronic use of apraclonidine decreases its moderation of post-laser intraocular pressure spikes.
    Ophthalmology, 1997, Volume: 104, Issue:11

    Topics: Adrenergic alpha-Agonists; Aged; Clonidine; Female; Glaucoma, Open-Angle; Humans; Intraocular Pressu

1997
Glaucoma drops control intraocular pressure and protect optic nerves in a rat model of glaucoma.
    Investigative ophthalmology & visual science, 1998, Volume: 39, Issue:3

    Topics: Adrenergic alpha-Agonists; Adrenergic beta-Antagonists; Animals; Betaxolol; Clonidine; Disease Model

1998
The effect of aqueous humor suppressants on intravitreal gas bubble duration in rabbits.
    American journal of ophthalmology, 1998, Volume: 125, Issue:5

    Topics: Absorption; Administration, Topical; Animals; Aqueous Humor; Clonidine; Fluorocarbons; Injections; I

1998
Glaucomatocyclitic crisis in a child.
    American journal of ophthalmology, 1998, Volume: 126, Issue:1

    Topics: Adolescent; Clonidine; Corneal Edema; Diagnosis, Differential; Drug Therapy, Combination; Glaucoma;

1998
Effects of drugs acting on adrenergic and adenosine receptors on the intraocular pressure and the activity of adenylyl cyclase in ciliary processes and their sensitivity to pertussis toxin.
    Physiological research, 1997, Volume: 46, Issue:3

    Topics: Adenosine; Adenylate Cyclase Toxin; Adenylyl Cyclases; Adrenergic Agonists; Adrenergic alpha-Antagon

1997
Intraocular pressure in rabbits by telemetry II: effects of animal handling and drugs.
    Investigative ophthalmology & visual science, 1998, Volume: 39, Issue:12

    Topics: Animal Husbandry; Animals; Circadian Rhythm; Clonidine; Epinephrine; Intraocular Pressure; Latanopro

1998
The rarity of clinically significant rise in intraocular pressure after laser peripheral iridotomy with apraclonidine.
    Ophthalmology, 1998, Volume: 105, Issue:12

    Topics: Adrenergic alpha-Agonists; Adult; Aged; Aged, 80 and over; Chemotherapy, Adjuvant; Clonidine; Female

1998
Ultrabiomicroscopic study of the effects of brimonidine, apraclonidine, latanoprost and ibopamine on the chamber angle and ciliary body.
    Acta ophthalmologica Scandinavica. Supplement, 1998, Issue:227

    Topics: Adrenergic alpha-Agonists; Aged; Anterior Chamber; Brimonidine Tartrate; Ciliary Body; Clonidine; De

1998
Aqueous humor dynamics in anesthetized rats infused with intracameral apraclonidine.
    Pharmacology, 1999, Volume: 58, Issue:4

    Topics: Adrenergic alpha-Agonists; Analysis of Variance; Anesthesia; Animals; Anterior Chamber; Aqueous Humo

1999
[Four new drugs for glaucoma: apraclonidine, brimonidine, dorzolamide and latanoprost].
    Nederlands tijdschrift voor geneeskunde, 1999, Jan-30, Volume: 143, Issue:5

    Topics: Adrenergic alpha-Agonists; Brimonidine Tartrate; Carbonic Anhydrase Inhibitors; Clonidine; Drug Appr

1999
Inverted U' strategy for short pulsed laser posterior capsulotomy.
    Acta ophthalmologica Scandinavica, 1999, Volume: 77, Issue:5

    Topics: Acetazolamide; Adrenergic alpha-Agonists; Cataract Extraction; Clonidine; Humans; Intraocular Pressu

1999
Medical control of IOP after cataract surgery.
    Journal of cataract and refractive surgery, 2000, Volume: 26, Issue:2

    Topics: Acetazolamide; Adrenergic alpha-Agonists; Carbonic Anhydrase Inhibitors; Clonidine; Drug Therapy, Co

2000
Ophthaproblem. Acute angle-closure glaucoma.
    Canadian family physician Medecin de famille canadien, 2000, Volume: 46

    Topics: Acetazolamide; Acute Disease; Adrenergic alpha-Agonists; Adrenergic beta-Antagonists; Carbonic Anhyd

2000
Clonidine provides an allergy-free alternative in glaucoma patients with proven allergy to apraclonidine.
    Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 2000, Volume: 238, Issue:2

    Topics: Adolescent; Adrenergic alpha-Agonists; Adult; Aged; Aged, 80 and over; Clonidine; Conjunctivitis, Al

2000
Effect of SR121463, a selective non-peptide vasopressin V2 receptor antagonist, in a rabbit model of ocular hypertension.
    Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics, 2000, Volume: 16, Issue:3

    Topics: Administration, Oral; Administration, Topical; Animals; Antidiuretic Hormone Receptor Antagonists; C

2000
Pharmacology of the intraocular pressure (IOP) lowering effect of systemic dexanabinol (HU-211), a non-psychotropic cannabinoid.
    Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics, 2000, Volume: 16, Issue:3

    Topics: Animals; Aqueous Humor; Blood Pressure; Cannabinoids; Clonidine; Dose-Response Relationship, Drug; D

2000
Ocular effects of apraclonidine in Horner syndrome.
    Archives of ophthalmology (Chicago, Ill. : 1960), 2000, Volume: 118, Issue:7

    Topics: Adrenergic alpha-Agonists; Aqueous Humor; Ciliary Body; Clonidine; Cohort Studies; Horner Syndrome;

2000
Immediate diode laser peripheral iridoplasty as treatment of acute attack of primary angle closure glaucoma: a preliminary study.
    Journal of glaucoma, 2001, Volume: 10, Issue:2

    Topics: Acute Disease; Adrenergic alpha-Agonists; Adrenergic beta-Antagonists; Aged; Aged, 80 and over; Clon

2001
[Iopidine in the control of intraocular pressure after glaucoma laser treatment].
    Oftalmologia (Bucharest, Romania : 1990), 2001, Volume: 54, Issue:4

    Topics: Adrenergic alpha-Agonists; Clonidine; Glaucoma; Humans; Intraocular Pressure; Laser Therapy; Postope

2001
[The influence of isoglaucon on the hydrodynamics and haemodynamics of the eye (author's transl)].
    Klinische Monatsblatter fur Augenheilkunde, 1975, Volume: 167, Issue:4

    Topics: Animals; Aqueous Humor; Blood Pressure; Clonidine; Glaucoma; Hemodynamics; Humans; Hydrogen-Ion Conc

1975
The intraocular pressure response of conscious rabbits to clonidine.
    Investigative ophthalmology, 1976, Volume: 15, Issue:10

    Topics: Administration, Topical; Adrenergic alpha-Antagonists; Animals; Clonidine; Dose-Response Relationshi

1976
The peripheral and central neural actions of clonidine in normal and glaucomatous eyes.
    Investigative ophthalmology & visual science, 1978, Volume: 17, Issue:2

    Topics: Adrenergic alpha-Antagonists; Adult; Aged; Aqueous Humor; Blood Pressure; Brachial Artery; Central N

1978
Clonidin effect on the intraocular pressure and eye circulation [proceedings].
    Acta ophthalmologica. Supplementum, 1975, Issue:125

    Topics: Clonidine; Dose-Response Relationship, Drug; Eye; Follow-Up Studies; Glaucoma; Humans; Intraocular P

1975
An increase in intraocular pressure due to clonidine.
    Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie. Albrecht von Graefe's archive for clinical and experimental ophthalmology, 1978, Aug-16, Volume: 207, Issue:3

    Topics: Animals; Blood Pressure; Carotid Arteries; Cats; Clonidine; Female; Gallamine Triethiodide; Injectio

1978
The distribution in the eye and the effect on intraocular pressure of clonidine.
    Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie. Albrecht von Graefe's archive for clinical and experimental ophthalmology, 1979, Jan-15, Volume: 209, Issue:3

    Topics: Animals; Blood Pressure; Carotid Artery, External; Cats; Clonidine; Dose-Response Relationship, Drug

1979
The central ocular hypotensive effect of clonidine.
    Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie. Albrecht von Graefe's archive for clinical and experimental ophthalmology, 1979, Apr-02, Volume: 210, Issue:2

    Topics: Animals; Blood Pressure; Cats; Clonidine; Dose-Response Relationship, Drug; Eye; Female; Infusions,

1979
The influence of acute and chronic cervical sympathectomy on the ocular hypotensive effect of clonidine.
    Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie. Albrecht von Graefe's archive for clinical and experimental ophthalmology, 1979, Volume: 212, Issue:1

    Topics: Animals; Cats; Clonidine; Depression, Chemical; Female; Injections, Intravenous; Intraocular Pressur

1979
The influence of clonidine on intraocular pressure after topical application to the eyes of anesthetized cats.
    Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie. Albrecht von Graefe's archive for clinical and experimental ophthalmology, 1979, Volume: 212, Issue:1

    Topics: Administration, Topical; Animals; Blood Pressure; Brain Chemistry; Cats; Clonidine; Eye; Female; Int

1979
[Bupranolol eye-drops (Ophtorenin) in long-term therapy of glaucoma (author's transl)].
    Klinische Monatsblatter fur Augenheilkunde, 1979, Volume: 174, Issue:2

    Topics: Acetazolamide; Adult; Aged; Bupranolol; Clonidine; Drug Combinations; Drug Tolerance; Female; Glauco

1979
The influence of clonidine on intraocular pressure.
    Documenta ophthalmologica. Advances in ophthalmology, 1979, Mar-15, Volume: 46, Issue:2

    Topics: Animals; Blood Pressure; Brain Stem; Carotid Artery, External; Cats; Clonidine; Female; Femoral Vein

1979
[Results of iridocycloretraction in the treatment of neovascular glaucoma].
    Minerva medica, 1979, Oct-20, Volume: 70, Issue:45

    Topics: Clonidine; Conjunctiva; Female; Glaucoma; Humans; Intraocular Pressure; Iris; Male; Middle Aged

1979
[The effect of topical clonidine on intraocular pressure in patients with glaucoma].
    Minerva medica, 1979, Oct-20, Volume: 70, Issue:45

    Topics: Administration, Topical; Adult; Aged; Clonidine; Female; Glaucoma; Humans; Intraocular Pressure; Mal

1979
Clonidine.
    Archives of ophthalmology (Chicago, Ill. : 1960), 1978, Volume: 96, Issue:11

    Topics: Animals; Aqueous Humor; Cats; Ciliary Body; Clonidine; Female; Intraocular Pressure; Iris; Male; Vas

1978
[Deendence of intraocular pressure on blood pressure, circulatory volume, and resistance to flow (clinical and experimental animal studies].
    Advances in ophthalmology = Fortschritte der Augenheilkunde = Progres en ophtalmologie, 1975, Volume: 29

    Topics: Animals; Blood Pressure; Blood Volume; Carotid Arteries; Cerebrovascular Circulation; Clonidine; Dep

1975
Ocular effects of clonidine in cats and monkeys (Macaca irus).
    Experimental eye research, 1975, Volume: 21, Issue:5

    Topics: Animals; Aqueous Humor; Blood Pressure; Cats; Ciliary Body; Clonidine; Eye; Female; Glaucoma; Haplor

1975
[Treatment results with isoglaucon eye drops in sympatheticotone patients with early appearing primary glaucoma (author's transl)].
    Klinische Monatsblatter fur Augenheilkunde, 1977, Volume: 170, Issue:1

    Topics: Adult; Blood Pressure; Clonidine; Glaucoma; Humans; Intraocular Pressure; Male; Middle Aged; Sympath

1977
[Approaches in medical treatment in glaucoma (author's transl)].
    Klinische Monatsblatter fur Augenheilkunde, 1977, Volume: 170, Issue:2

    Topics: Acetazolamide; Antihypertensive Agents; Clonidine; Delayed-Action Preparations; Glaucoma; Guanethidi

1977
[Recent aspects in the treatment of glaucoma].
    Therapie der Gegenwart, 1977, Volume: 116, Issue:9

    Topics: Acetazolamide; Clonidine; Glaucoma; Humans; Intraocular Pressure

1977
[Ocular hypotensive effect of alpha-adrenoceptor agonist and antagonist in the conscious pigmented rabbit].
    Nippon Ganka Gakkai zasshi, 1992, Volume: 96, Issue:2

    Topics: Administration, Topical; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Cerebral

1992
Prophylactic use of apraclonidine for intraocular pressure increase after Nd:YAG Capsulotomies.
    American journal of ophthalmology, 1992, Sep-15, Volume: 114, Issue:3

    Topics: Adrenergic alpha-Agonists; Cataract Extraction; Clonidine; Humans; Intraocular Pressure; Laser Thera

1992
Effects of lofexidine, an alpha 2-adrenoreceptor agonist, on ocular blood flow and ion transport of rabbit iris-ciliary body.
    Journal of ocular pharmacology, 1992,Spring, Volume: 8, Issue:1

    Topics: Adrenergic alpha-Agonists; Animals; Biological Transport; Ciliary Body; Clonidine; Female; Hemodynam

1992
Apraclonidine and argon laser trabeculoplasty.
    American journal of ophthalmology, 1992, Dec-15, Volume: 114, Issue:6

    Topics: Adrenergic alpha-Agonists; Clonidine; Glaucoma; Humans; Intraocular Pressure; Laser Therapy; Pilocar

1992
[The role of sympathetic cervical ganglion in the effect of clonidine for lowering intraocular pressure].
    Nippon Ganka Gakkai zasshi, 1992, Volume: 96, Issue:2

    Topics: Animals; Clonidine; Depression, Chemical; Ganglia, Sympathetic; Ganglionectomy; Intraocular Pressure

1992
Early intraocular pressure response to laser trabeculoplasty 180 degrees without apraclonidine versus 360 degrees with apraclonidine.
    Ophthalmic surgery, 1991, Volume: 22, Issue:9

    Topics: Adrenergic alpha-Agonists; Aged; Clonidine; Female; Glaucoma; Humans; Intraocular Pressure; Laser Th

1991
[The ocular hypotensive effect and side reactions of domestic clonidine eyedrops].
    [Zhonghua yan ke za zhi] Chinese journal of ophthalmology, 1991, Volume: 27, Issue:3

    Topics: Blood Pressure; Clonidine; Glaucoma; Humans; Intraocular Pressure; Ophthalmic Solutions

1991
Failure of apraclonidine to prevent delayed IOP elevation after Nd:YAG laser posterior capsulotomy.
    Transactions of the American Ophthalmological Society, 1990, Volume: 88

    Topics: Adrenergic alpha-Agonists; Aged; Clonidine; Glaucoma, Open-Angle; Humans; Intraocular Pressure; Lase

1990
Apraclonidine effects on ocular responses to YAG laser irradiation to the rabbit iris.
    Investigative ophthalmology & visual science, 1990, Volume: 31, Issue:4

    Topics: Animals; Aqueous Humor; Clonidine; Dinoprostone; Dose-Response Relationship, Radiation; Eye; Eye Pro

1990
Delayed increased intraocular pressure after Nd:YAG laser posterior capsulotomy in a patient treated with apraclonidine.
    American journal of ophthalmology, 1990, Jul-15, Volume: 110, Issue:1

    Topics: Aged; Clonidine; Humans; Intraocular Pressure; Laser Therapy; Lens Capsule, Crystalline; Lens, Cryst

1990
Near syncope and chest tightness after administration of apraclonidine before argon laser iridotomy.
    American journal of ophthalmology, 1990, Sep-15, Volume: 110, Issue:3

    Topics: Aged; Argon; Chest Pain; Clonidine; Female; Humans; Intraocular Pressure; Iris; Laser Therapy; Posto

1990
[Conservative treatment of glaucoma].
    Klinika oczna, 1989, Volume: 91, Issue:6

    Topics: Acetazolamide; Clonidine; Drug Evaluation; Epinephrine; Glaucoma; Humans; Intraocular Pressure; Moxi

1989
The role of prostaglandins in the para-aminoclonidine-induced reduction of intraocular pressure.
    Transactions of the American Ophthalmological Society, 1989, Volume: 87

    Topics: Administration, Topical; Animals; Aqueous Humor; Clonidine; Dinoprost; Dinoprostone; Disease Models,

1989
The role of apraclonidine hydrochloride in laser therapy for glaucoma.
    Transactions of the American Ophthalmological Society, 1989, Volume: 87

    Topics: Acetazolamide; Adult; Aged; Animals; Clonidine; Epinephrine; Female; Glaucoma, Open-Angle; Humans; I

1989
Apraclonidine hydrochloride in vitreoretinal surgery.
    Archives of ophthalmology (Chicago, Ill. : 1960), 1989, Volume: 107, Issue:3

    Topics: Adult; Clonidine; Female; Glaucoma; Humans; Intraocular Pressure; Male; Middle Aged; Retina; Retinal

1989
Use of apraclonidine to reduce acute intraocular pressure rise following Q-switched Nd:YAG laser iridotomy.
    Ophthalmic surgery, 1989, Volume: 20, Issue:1

    Topics: Aged; Clonidine; Female; Glaucoma; Gonioscopy; Humans; Intraocular Pressure; Iris; Laser Therapy; Ma

1989
Hypotony following instillation of apraclonidine for increased intraocular pressure after trabeculoplasty.
    American journal of ophthalmology, 1989, Aug-15, Volume: 108, Issue:2

    Topics: Aged; Clonidine; Humans; Intraocular Pressure; Male; Ocular Hypertension; Recurrence; Trabeculectomy

1989
[Possible mechanism of the ocular hypotensive effect of clonidine in the pigmented eye rabbit].
    Nippon Ganka Gakkai zasshi, 1988, Volume: 92, Issue:9

    Topics: Adrenergic alpha-Agonists; Animals; Blood Pressure; Clonidine; Ganglia, Sympathetic; Ganglionectomy;

1988
The prevention of an acute rise in intraocular pressure following Q-switched Nd:YAG laser iridotomy with clonidine.
    Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 1989, Volume: 227, Issue:1

    Topics: Administration, Topical; Adult; Aged; Blood Pressure; Clonidine; Female; Glaucoma; Gonioscopy; Human

1989
Central regulation of intraocular pressure and cardiovascular apparatus with clonidine in conscious rabbits.
    Zhongguo yao li xue bao = Acta pharmacologica Sinica, 1988, Volume: 9, Issue:4

    Topics: Animals; Blood Pressure; Clonidine; Heart Rate; Injections, Intraventricular; Intraocular Pressure;

1988
The safety and efficacy of topical 1% ALO 2145 (p-aminoclonidine hydrochloride) in normal volunteers.
    Archives of ophthalmology (Chicago, Ill. : 1960), 1987, Volume: 105, Issue:9

    Topics: Adult; Blood Pressure; Body Water; Clonidine; Female; Humans; Intraocular Pressure; Male; Middle Age

1987
Effects of topical ALO 2145 (p-aminoclonidine hydrochloride, aplonidine hydrochloride) on the acute intraocular pressure rise after argon laser iridotomy.
    Archives of ophthalmology (Chicago, Ill. : 1960), 1988, Volume: 106, Issue:3

    Topics: Administration, Topical; Clonidine; Humans; Intraocular Pressure; Iris; Laser Therapy

1988
The ocular effects of xylazine in rabbits, cats, and monkeys.
    Journal of ocular pharmacology, 1986,Winter, Volume: 2, Issue:1

    Topics: Animals; Cats; Cebus; Clonidine; Female; Intraocular Pressure; Male; Nictitating Membrane; Pupil; Ra

1986
Study of central regulation of intraocular pressure using ventriculocisternal perfusion.
    Investigative ophthalmology & visual science, 1985, Volume: 26, Issue:2

    Topics: Alprostadil; Animals; Blood Pressure; Blood-Brain Barrier; Brain; Clonidine; Eye; Heart Rate; Infusi

1985
[Letter: Glaucoma and clonidine. A new therapeutic possibility].
    La Nouvelle presse medicale, 1974, Dec-28, Volume: 3, Issue:45

    Topics: Chronic Disease; Clonidine; Drug Tolerance; Follow-Up Studies; Glaucoma; Humans; Intraocular Pressur

1974
[Intraocular pressure, blood pressure, and glaucoma damage. Comparative perimetric studies on the relationship between the increase of intraocular pressure, blood sedimentation, and visual-field disorders in primary glaucoma].
    Bucherei des Augenarztes, 1972, Volume: 61

    Topics: Acetazolamide; Adult; Aged; Analysis of Variance; Blood Pressure; Clonidine; Female; Glaucoma; Human

1972
[The influence of clonidin (isoglaucon) eyedrops on blood pressure, intraocular pressure and cerebral blood flow in healthy persons, hypertonic and glaucoma patients (author's transl)].
    Klinische Monatsblatter fur Augenheilkunde, 1973, Volume: 163, Issue:1

    Topics: Administration, Topical; Arterial Occlusive Diseases; Arteriosclerosis; Blood Pressure; Cerebrovascu

1973
Proceedings: Intraocular pressure, blood pressure and the optic nerve.
    Experimental eye research, 1973, Nov-25, Volume: 17, Issue:4

    Topics: Blood Pressure; Clonidine; Glaucoma; Humans; Intraocular Pressure; Optic Nerve

1973
The Clonidine side effect in the human eye.
    Annals of ophthalmology, 1974, Volume: 6, Issue:7

    Topics: Adult; Aged; Animals; Clonidine; Color Perception; Dark Adaptation; Electrooculography; Eye; Female;

1974
[On the effect of clonidine on ocular and brachial pressure with normal intraocular pressure, with glaucoma simplex chronicum and with juvenile].
    Bucherei des Augenarztes, 1974, Volume: 63

    Topics: Blood Pressure; Clonidine; Glaucoma; Humans; Intraocular Pressure

1974
[Clonidine in glaucoma therapy].
    Bucherei des Augenarztes, 1974, Volume: 63

    Topics: Clonidine; Glaucoma; Humans; Intraocular Pressure; Time Factors

1974
[Decrease of intraocular pressure by clonidine. Its relation to cerebral blood flow and blood pressure changes].
    Bucherei des Augenarztes, 1974, Volume: 63

    Topics: Blood Pressure; Cerebrovascular Circulation; Clonidine; Humans; Intraocular Pressure; Time Factors

1974
[Comparative ophthalmodynamography studies with clonidine].
    Bucherei des Augenarztes, 1974, Volume: 63

    Topics: Adult; Aged; Clonidine; Humans; Intraocular Pressure; Middle Aged; Ophthalmodynamometry

1974
[Comparative perimetric studies with clonidine].
    Bucherei des Augenarztes, 1974, Volume: 63

    Topics: Acetazolamide; Clonidine; Humans; Intraocular Pressure; Visual Field Tests

1974
[Effect of clonidine on intraocular pressure in acute glaucoma].
    Bucherei des Augenarztes, 1974, Volume: 63

    Topics: Clonidine; Glaucoma; Humans; Intraocular Pressure

1974
[Results of clonidine in one eighth percent solution in hard glaucoma attacks in personal practice].
    Bucherei des Augenarztes, 1974, Volume: 63

    Topics: Clonidine; Glaucoma; Humans; Intraocular Pressure; Pupil

1974
[Results with clonidine (St 155) 0.125 percent in ophthalmologic practice].
    Bucherei des Augenarztes, 1974, Volume: 63

    Topics: Blood Pressure; Clonidine; Humans; Intraocular Pressure

1974
[Lowering of intraocular pressure with clonidin].
    Klinische Monatsblatter fur Augenheilkunde, 1972, Volume: 160, Issue:2

    Topics: Acetazolamide; Aged; Antihypertensive Agents; Blood Pressure; Clonidine; Drug Combinations; Glaucoma

1972