clonidine has been researched along with Innate Inflammatory Response in 32 studies
Clonidine: An imidazoline sympatholytic agent that stimulates ALPHA-2 ADRENERGIC RECEPTORS and central IMIDAZOLINE RECEPTORS. It is commonly used in the management of HYPERTENSION.
clonidine (amino form) : A clonidine that is 4,5-dihydro-1H-imidazol-2-amine in which one of the amino hydrogens is replaced by a 2,6-dichlorophenyl group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The α2 agonists, dexmedetomidine and clonidine, are used as sedative drugs during critical illness." | 9.01 | The effect of dexmedetomidine and clonidine on the inflammatory response in critical illness: a systematic review of animal and human studies. ( Baillie, JK; Edwardson, SA; Flanders, CA; Rocke, AS; Walsh, TS, 2019) |
| " This study evaluated the effect of the adrenergic alpha 2 agonist clonidine on microvascular permeability and leukocyte adhesion during endotoxemia." | 7.81 | Time-dependent effect of clonidine on microvascular permeability during endotoxemia. ( Brenner, T; Hernekamp, JF; Hofer, S; Philipsenburg, C; Schmidt, K; Zivkovic, AR, 2015) |
| "Clonidine can effectively reduce pain and/or hypersensitivity." | 7.74 | Effects of topical application of clonidine cream on pain behaviors and spinal Fos protein expression in rat models of neuropathic pain, postoperative pain, and inflammatory pain. ( Arita, H; Hanaoka, K; Hayashida, M; Li, C; Sawamura, S; Sekiyama, H; Sumida, T; Takeda, K; Yamada, Y, 2007) |
| "We studied whether peripheral alpha2-adrenergic receptors are involved in the antihyperalgesic effects of oxcarbazepine by examining the effects of yohimbine (selective alpha2-adrenoceptor antagonist), BRL 44408 (selective alpha(2A)-adrenoceptor antagonist), MK-912 (selective alpha2C-adrenoceptor antagonist), and clonidine (alpha2-adrenoceptor agonist) on the antihyperalgesic effect of oxcarbazepine in the rat model of inflammatory pain." | 7.74 | The involvement of peripheral alpha 2-adrenoceptors in the antihyperalgesic effect of oxcarbazepine in a rat model of inflammatory pain. ( Bosković, B; Paranos, SLj; Prostran, MS; Stepanović-Petrović, RM; Tomić, MA; Ugresić, ND; Vucković, SM, 2007) |
| "We investigated the interaction between spinally administered bupivacaine and clonidine using an animal model of acute and inflammatory pain." | 7.72 | Intrathecal clonidine and bupivacaine have synergistic analgesia for acute thermally or inflammatory-induced pain in rats. ( Hanaoka, K; Nishiyama, T, 2004) |
| "Spinally-administered midazolam, a benzodiazepine, and clonidine, an alpha2-adrenergic receptor agonist, have significant synergistic effects on thermally-induced acute and formalin-induced inflammatory pain." | 7.71 | The synergistic interaction between midazolam and clonidine in spinally-mediated analgesia in two different pain models of rats. ( Hanaoka, K; Nishiyama, T, 2001) |
| " Tolerance was induced with a morphine pellet (75 mg) implanted for 72 h, and inflammation with intragastric croton oil." | 7.70 | Intestinal inflammation and morphine tolerance alter the interaction between morphine and clonidine on gastrointestinal transit in mice. ( Pol, O; Puig, MM; Warner, W, 2000) |
| "Chronic pain is a major health issue and most patients suffer from spontaneous pain." | 5.42 | Huperzine A Alleviates Mechanical Allodynia but Not Spontaneous Pain via Muscarinic Acetylcholine Receptors in Mice. ( Feng, ZH; Li, XY; Liu, L; Mei, SH; Wang, M; Wang, Y; Wang, YJ; Zuo, ZX, 2015) |
| "The α2 agonists, dexmedetomidine and clonidine, are used as sedative drugs during critical illness." | 5.01 | The effect of dexmedetomidine and clonidine on the inflammatory response in critical illness: a systematic review of animal and human studies. ( Baillie, JK; Edwardson, SA; Flanders, CA; Rocke, AS; Walsh, TS, 2019) |
| "Clonidine increased VEGF and VEGF-receptor expression, decreased HMGB1 expression, decreased lung inflammation, and improved lung tissue repair." | 3.85 | Clonidine restores vascular endothelial growth factor expression and improves tissue repair following severe trauma. ( Alamo, IG; Efron, PA; Kannan, KB; Loftus, TJ; Millar, JK; Mohr, AM; Plazas, JM; Thomson, AJ; Whitley, EE, 2017) |
| " This study evaluated the effect of the adrenergic alpha 2 agonist clonidine on microvascular permeability and leukocyte adhesion during endotoxemia." | 3.81 | Time-dependent effect of clonidine on microvascular permeability during endotoxemia. ( Brenner, T; Hernekamp, JF; Hofer, S; Philipsenburg, C; Schmidt, K; Zivkovic, AR, 2015) |
| "Clonidine can effectively reduce pain and/or hypersensitivity." | 3.74 | Effects of topical application of clonidine cream on pain behaviors and spinal Fos protein expression in rat models of neuropathic pain, postoperative pain, and inflammatory pain. ( Arita, H; Hanaoka, K; Hayashida, M; Li, C; Sawamura, S; Sekiyama, H; Sumida, T; Takeda, K; Yamada, Y, 2007) |
| "We studied whether peripheral alpha2-adrenergic receptors are involved in the antihyperalgesic effects of oxcarbazepine by examining the effects of yohimbine (selective alpha2-adrenoceptor antagonist), BRL 44408 (selective alpha(2A)-adrenoceptor antagonist), MK-912 (selective alpha2C-adrenoceptor antagonist), and clonidine (alpha2-adrenoceptor agonist) on the antihyperalgesic effect of oxcarbazepine in the rat model of inflammatory pain." | 3.74 | The involvement of peripheral alpha 2-adrenoceptors in the antihyperalgesic effect of oxcarbazepine in a rat model of inflammatory pain. ( Bosković, B; Paranos, SLj; Prostran, MS; Stepanović-Petrović, RM; Tomić, MA; Ugresić, ND; Vucković, SM, 2007) |
| "We investigated the interaction between spinally administered bupivacaine and clonidine using an animal model of acute and inflammatory pain." | 3.72 | Intrathecal clonidine and bupivacaine have synergistic analgesia for acute thermally or inflammatory-induced pain in rats. ( Hanaoka, K; Nishiyama, T, 2004) |
| "Spinally-administered midazolam, a benzodiazepine, and clonidine, an alpha2-adrenergic receptor agonist, have significant synergistic effects on thermally-induced acute and formalin-induced inflammatory pain." | 3.71 | The synergistic interaction between midazolam and clonidine in spinally-mediated analgesia in two different pain models of rats. ( Hanaoka, K; Nishiyama, T, 2001) |
| " Tolerance was induced with a morphine pellet (75 mg) implanted for 72 h, and inflammation with intragastric croton oil." | 3.70 | Intestinal inflammation and morphine tolerance alter the interaction between morphine and clonidine on gastrointestinal transit in mice. ( Pol, O; Puig, MM; Warner, W, 2000) |
| " The toxic contact reaction to croton oil (nonspecific cutaneous inflammation) was not affected." | 3.67 | Effects of clonidine on the dermal inflammatory cell response of experimental toxic and allergic contact reactions and intradermal hypersensitivity. ( Anderson, CD; Andersson, RG; Lindgren, BR, 1987) |
| "Nevertheless, refractory septic shock still carries a mortality close to 100%." | 2.52 | Pressor Response to Noradrenaline in the Setting of Septic Shock: Anything New under the Sun-Dexmedetomidine, Clonidine? A Minireview. ( Géloën, A; Ghignone, M; Julien, C; Leroy, S; May, CN; Pichot, C; Quintin, L, 2015) |
| "Chronic pain is a major health issue and most patients suffer from spontaneous pain." | 1.42 | Huperzine A Alleviates Mechanical Allodynia but Not Spontaneous Pain via Muscarinic Acetylcholine Receptors in Mice. ( Feng, ZH; Li, XY; Liu, L; Mei, SH; Wang, M; Wang, Y; Wang, YJ; Zuo, ZX, 2015) |
| "PSNL induced bilateral behavioral hyperalgesia, with the ipsilateral level displaying a higher extent of behavior changes than the contralateral side." | 1.37 | Effects of clonidine on bilateral pain behaviors and inflammatory response in rats under the state of neuropathic pain. ( Dong, R; Feng, X; Li, W; Liu, J; Wang, H; Xu, J; Yu, B; Zhang, F, 2011) |
| " In combination with either low or high frequency TENS, the dose-response curve shifted to the left and was significantly different from clonidine alone." | 1.31 | Enhanced reduction in hyperalgesia by combined administration of clonidine and TENS. ( Chandran, P; Sluka, KA, 2002) |
| "Clonidine was more potent in CCI then in CFA rats in reducing the response to cold." | 1.30 | The cold plate as a test of nociceptive behaviors: description and application to the study of chronic neuropathic and inflammatory pain models. ( Franssen, M; Goff, JR; Janni, G; Jasmin, L; Kohan, L, 1998) |
| " Dose-response curves for intrathecally administered agonists with mu- and/or delta-opioid activity were shifted to the left for inflamed hindpaws when compared to contralateral non-inflamed paws." | 1.28 | Spinal opioid analgesic effects are enhanced in a model of unilateral inflammation/hyperalgesia: possible involvement of noradrenergic mechanisms. ( Dubner, R; Hylden, JL; Iadarola, MJ; Nahin, RL; Thomas, DA, 1991) |
| "Clonidine was found to abolish dose-dependently MK 422-potentiated ovalbumin-evoked inflammatory dermal responses and it possesses additive hypotensive effects when combined with the ACE inhibitor." | 1.27 | Effects of an alpha-2 adrenoceptor agonist on angiotensin converting enzyme inhibitor-induced hypotension and potentiated allergen-evoked inflammatory skin responses. ( Andersson, RG; Grundström, N; Lindgren, BR, 1988) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (12.50) | 18.7374 |
| 1990's | 3 (9.38) | 18.2507 |
| 2000's | 11 (34.38) | 29.6817 |
| 2010's | 12 (37.50) | 24.3611 |
| 2020's | 2 (6.25) | 2.80 |
| Authors | Studies |
|---|---|
| Wu, YJ | 1 |
| Guernon, J | 1 |
| McClure, A | 1 |
| Luo, G | 1 |
| Rajamani, R | 1 |
| Ng, A | 1 |
| Easton, A | 1 |
| Newton, A | 1 |
| Bourin, C | 1 |
| Parker, D | 1 |
| Mosure, K | 1 |
| Barnaby, O | 1 |
| Soars, MG | 1 |
| Knox, RJ | 1 |
| Matchett, M | 1 |
| Pieschl, R | 1 |
| Herrington, J | 1 |
| Chen, P | 1 |
| Sivarao, DV | 1 |
| Bristow, LJ | 1 |
| Meanwell, NA | 1 |
| Bronson, J | 1 |
| Olson, R | 1 |
| Thompson, LA | 1 |
| Dzierba, C | 1 |
| Flanders, CA | 1 |
| Rocke, AS | 1 |
| Edwardson, SA | 1 |
| Baillie, JK | 1 |
| Walsh, TS | 1 |
| Gus, EI | 1 |
| Shahrokhi, S | 1 |
| Jeschke, MG | 1 |
| Hyoju, SK | 1 |
| Zaborina, O | 1 |
| van Goor, H | 1 |
| Loftus, TJ | 1 |
| Thomson, AJ | 1 |
| Kannan, KB | 1 |
| Alamo, IG | 1 |
| Millar, JK | 1 |
| Plazas, JM | 1 |
| Whitley, EE | 1 |
| Efron, PA | 1 |
| Mohr, AM | 1 |
| Fan, QQ | 1 |
| Li, L | 1 |
| Wang, WT | 1 |
| Yang, X | 2 |
| Suo, ZW | 2 |
| Hu, XD | 2 |
| Wang, XT | 1 |
| Lian, X | 1 |
| Xu, YM | 1 |
| De Andres, J | 1 |
| Asensio-Samper, JM | 1 |
| Fabregat-Cid, G | 1 |
| El-Naga, RN | 1 |
| Ahmed, HI | 1 |
| Abd Al Haleem, EN | 1 |
| Schmidt, K | 1 |
| Hernekamp, JF | 1 |
| Philipsenburg, C | 1 |
| Zivkovic, AR | 1 |
| Brenner, T | 1 |
| Hofer, S | 1 |
| Zuo, ZX | 1 |
| Wang, YJ | 1 |
| Liu, L | 1 |
| Wang, Y | 1 |
| Mei, SH | 1 |
| Feng, ZH | 1 |
| Wang, M | 1 |
| Li, XY | 1 |
| Géloën, A | 1 |
| Pichot, C | 1 |
| Leroy, S | 1 |
| Julien, C | 1 |
| Ghignone, M | 1 |
| May, CN | 1 |
| Quintin, L | 1 |
| Persec, J | 1 |
| Persec, Z | 1 |
| Buković, D | 1 |
| Merc, V | 1 |
| Pavelić, J | 1 |
| Zupić, T | 1 |
| Zhang, F | 1 |
| Feng, X | 1 |
| Dong, R | 1 |
| Wang, H | 1 |
| Liu, J | 1 |
| Li, W | 1 |
| Xu, J | 1 |
| Yu, B | 1 |
| Gourdin, M | 1 |
| Dubois, P | 1 |
| Mullier, F | 1 |
| Chatelain, B | 1 |
| Dogné, JM | 1 |
| Marchandise, B | 1 |
| Jamart, J | 1 |
| De Kock, M | 1 |
| Sluka, KA | 1 |
| Chandran, P | 1 |
| Yaksh, TL | 1 |
| Horais, KA | 1 |
| Tozier, NA | 1 |
| Allen, JW | 1 |
| Rathbun, M | 1 |
| Rossi, SS | 1 |
| Sommer, C | 1 |
| Meschter, C | 1 |
| Richter, PJ | 1 |
| Hildebrand, KR | 1 |
| Nishiyama, T | 2 |
| Hanaoka, K | 3 |
| Yoon, SY | 1 |
| Kim, HW | 1 |
| Roh, DH | 1 |
| Kwon, YB | 1 |
| Han, HJ | 1 |
| Beitz, AJ | 1 |
| Lee, JH | 1 |
| Homburger, JA | 1 |
| Meiler, SE | 1 |
| Li, C | 1 |
| Sekiyama, H | 1 |
| Hayashida, M | 1 |
| Takeda, K | 1 |
| Sumida, T | 1 |
| Sawamura, S | 1 |
| Yamada, Y | 1 |
| Arita, H | 1 |
| Tomić, MA | 1 |
| Vucković, SM | 1 |
| Stepanović-Petrović, RM | 1 |
| Ugresić, ND | 1 |
| Paranos, SLj | 1 |
| Prostran, MS | 1 |
| Bosković, B | 1 |
| Jugé, M | 1 |
| Grimaud, N | 1 |
| Petit, JY | 1 |
| Jasmin, L | 1 |
| Kohan, L | 1 |
| Franssen, M | 1 |
| Janni, G | 1 |
| Goff, JR | 1 |
| Puig, MM | 1 |
| Warner, W | 1 |
| Pol, O | 1 |
| McDougall, JJ | 1 |
| Chilla, R | 1 |
| Arold, R | 1 |
| Flucke, KH | 1 |
| Arglebe, C | 1 |
| Hylden, JL | 1 |
| Thomas, DA | 1 |
| Iadarola, MJ | 1 |
| Nahin, RL | 1 |
| Dubner, R | 1 |
| Lindgren, BR | 2 |
| Grundström, N | 1 |
| Andersson, RG | 2 |
| Anderson, CD | 1 |
| Perper, RJ | 1 |
| Sanda, M | 1 |
| Chinea, G | 1 |
| Oronsky, AL | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Clonidine for Tourniquet-related Pain in Children: A Pilot Study[NCT04564430] | Phase 4 | 20 participants (Anticipated) | Interventional | 2021-03-01 | Recruiting | ||
| Effect of a Perioperative Opioid Free Anaesthesia-Analgesia (OFA-A) Strategy on Surgical Stress Response and Immunomodulation in Elective VATS Lobectomy for NSCLC Lung Cancer: A Prospective Randomized Study[NCT05172739] | Phase 4 | 70 participants (Anticipated) | Interventional | 2021-10-01 | Recruiting | ||
| The Immune Response of Breast Cancer Patients Treated With Levobupivacaine Using Paravertebral or Superficial Chest Blocks[NCT05816538] | 100 participants (Anticipated) | Interventional | 2023-04-30 | Not yet recruiting | |||
| The Effects of Topical Treatment With Clonidine + Pentoxifylline in Patients With Neuropathic Pain[NCT03342950] | Phase 2 | 4 participants (Actual) | Interventional | 2019-02-19 | Terminated (stopped due to Low recruitment due to the COVID-19 pandemic) | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
5 reviews available for clonidine and Innate Inflammatory Response
| Article | Year |
|---|---|
The effect of dexmedetomidine and clonidine on the inflammatory response in critical illness: a systematic review of animal and human studies.
Topics: Adrenergic alpha-2 Receptor Agonists; Animals; Clonidine; Critical Illness; Dexmedetomidine; Disease | 2019 |
Anabolic and anticatabolic agents used in burn care: What is known and what is yet to be learned.
Topics: Anabolic Agents; Burns; Clonidine; Growth Hormone-Releasing Hormone; Hormones; Human Growth Hormone; | 2020 |
Intrathecal delivery of analgesics.
Topics: Analgesics, Opioid; Baclofen; Bupivacaine; Catheters, Indwelling; Chronic Pain; Clonidine; Drug Deli | 2014 |
Pressor Response to Noradrenaline in the Setting of Septic Shock: Anything New under the Sun-Dexmedetomidine, Clonidine? A Minireview.
Topics: Adrenergic alpha-2 Receptor Agonists; Animals; Clonidine; Dexmedetomidine; Humans; Inflammation; Mul | 2015 |
Anesthesia drugs, immunity, and long-term outcome.
Topics: Adrenergic alpha-Agonists; Adrenergic beta-Antagonists; Analgesics, Opioid; Anesthetics; Anesthetics | 2006 |
Anesthesia drugs, immunity, and long-term outcome.
Topics: Adrenergic alpha-Agonists; Adrenergic beta-Antagonists; Analgesics, Opioid; Anesthetics; Anesthetics | 2006 |
Anesthesia drugs, immunity, and long-term outcome.
Topics: Adrenergic alpha-Agonists; Adrenergic beta-Antagonists; Analgesics, Opioid; Anesthetics; Anesthetics | 2006 |
Anesthesia drugs, immunity, and long-term outcome.
Topics: Adrenergic alpha-Agonists; Adrenergic beta-Antagonists; Analgesics, Opioid; Anesthetics; Anesthetics | 2006 |
2 trials available for clonidine and Innate Inflammatory Response
| Article | Year |
|---|---|
Preoperative clonidine or levobupivacaine--effect on systemic inflammatory stress response.
Topics: Adrenergic alpha-Agonists; Analgesia, Epidural; Anesthetics, Local; Biomarkers; Bupivacaine; Clonidi | 2009 |
The effect of clonidine, an alpha-2 adrenergic receptor agonist, on inflammatory response and postischemic endothelium function during early reperfusion in healthy volunteers.
Topics: Adrenergic alpha-2 Receptor Agonists; Adult; Belgium; Biomarkers; Brachial Artery; CD11b Antigen; CD | 2012 |
25 other studies available for clonidine and Innate Inflammatory Response
| Article | Year |
|---|---|
Discovery of non-zwitterionic aryl sulfonamides as Na
Topics: Administration, Oral; Animals; Chronic Pain; Disease Models, Animal; Dose-Response Relationship, Dru | 2017 |
SARS-CoV-2 and the sympathetic immune response: Dampening inflammation with antihypertensive drugs (Clonidine and Propranolol).
Topics: Antihypertensive Agents; Antiviral Agents; Clonidine; Comorbidity; COVID-19; Disease Progression; Hu | 2020 |
Clonidine restores vascular endothelial growth factor expression and improves tissue repair following severe trauma.
Topics: Animals; Clonidine; HMGB1 Protein; Inflammation; Lung Injury; Propranolol; Pulmonary Edema; Rats; Ra | 2017 |
Activation of α2 adrenoceptors inhibited NMDA receptor-mediated nociceptive transmission in spinal dorsal horn of mice with inflammatory pain.
Topics: Adrenergic alpha-2 Receptor Agonists; Animals; Clonidine; Inflammation; Male; Mice; Nociception; Pai | 2014 |
α(2) noradrenergic receptor suppressed CaMKII signaling in spinal dorsal horn of mice with inflammatory pain.
Topics: Adrenergic alpha-2 Receptor Agonists; Animals; Calcium-Calmodulin-Dependent Protein Kinase Type 2; C | 2014 |
Effects of indole-3-carbinol on clonidine-induced neurotoxicity in rats: Impact on oxidative stress, inflammation, apoptosis and monoamine levels.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Apoptosis; Biogenic Monoamines; Brain; Clonidine; D | 2014 |
Time-dependent effect of clonidine on microvascular permeability during endotoxemia.
Topics: Animals; Capillary Permeability; Cell Adhesion; Clonidine; Endothelial Cells; Endotoxemia; Inflammat | 2015 |
Huperzine A Alleviates Mechanical Allodynia but Not Spontaneous Pain via Muscarinic Acetylcholine Receptors in Mice.
Topics: Acetylcholinesterase; Alkaloids; Ambenonium Chloride; Analgesics; Animals; Atropine; Behavior, Anima | 2015 |
Effects of clonidine on bilateral pain behaviors and inflammatory response in rats under the state of neuropathic pain.
Topics: Adrenergic alpha-2 Receptor Antagonists; Analgesics; Analysis of Variance; Animals; Clonidine; Cytok | 2011 |
Enhanced reduction in hyperalgesia by combined administration of clonidine and TENS.
Topics: Analgesics; Animals; Carrageenan; Clonidine; Combined Modality Therapy; Hyperalgesia; Inflammation; | 2002 |
Chronically infused intrathecal morphine in dogs.
Topics: Adrenergic alpha-Agonists; Analgesics, Opioid; Animals; Arousal; Behavior, Animal; Blood Pressure; C | 2003 |
Intrathecal clonidine and bupivacaine have synergistic analgesia for acute thermally or inflammatory-induced pain in rats.
Topics: Adrenergic alpha-Agonists; Anesthetics, Local; Animals; Behavior, Animal; Bupivacaine; Clonidine; Do | 2004 |
Intrathecal clonidine suppresses zymosan-induced peripheral leukocyte migration in a mouse air pouch model via activation of spinal muscarinic type 2 receptors and sympathoadrenal medullary activity.
Topics: Adrenalectomy; Analysis of Variance; Animals; Cell Count; Cell Movement; Choline O-Acetyltransferase | 2006 |
Effects of topical application of clonidine cream on pain behaviors and spinal Fos protein expression in rat models of neuropathic pain, postoperative pain, and inflammatory pain.
Topics: Administration, Topical; Analgesics; Animals; Behavior, Animal; Clonidine; Disease Models, Animal; D | 2007 |
The involvement of peripheral alpha 2-adrenoceptors in the antihyperalgesic effect of oxcarbazepine in a rat model of inflammatory pain.
Topics: Adrenergic alpha-2 Receptor Agonists; Animals; Carbamazepine; Clonidine; Disease Models, Animal; Dos | 2007 |
Involvement of alpha2-adrenergic mechanisms in experimental analgesic and anti-inflammatory activities of a benzamide derivative.
Topics: Adrenergic alpha-Agonists; Animals; Anti-Inflammatory Agents, Non-Steroidal; Benzamides; Blood Press | 1997 |
The cold plate as a test of nociceptive behaviors: description and application to the study of chronic neuropathic and inflammatory pain models.
Topics: Analgesics, Opioid; Anesthetics, Local; Animals; Behavior, Animal; Chronic Disease; Clonidine; Cold | 1998 |
Intestinal inflammation and morphine tolerance alter the interaction between morphine and clonidine on gastrointestinal transit in mice.
Topics: Analgesics; Analgesics, Opioid; Analysis of Variance; Animals; Clonidine; Croton Oil; Dermatologic A | 2000 |
Abrogation of alpha-adrenergic vasoactivity in chronically inflamed rat knee joints.
Topics: Administration, Topical; Adrenergic alpha-1 Receptor Agonists; Adrenergic alpha-1 Receptor Antagonis | 2001 |
The synergistic interaction between midazolam and clonidine in spinally-mediated analgesia in two different pain models of rats.
Topics: Adrenergic alpha-Agonists; Analgesia; Anesthetics, Intravenous; Animals; Behavior, Animal; Clonidine | 2001 |
The effect of clonidine treatment on the salivary glands of the rat. Results of biochemical and histological investigations.
Topics: Amylases; Animals; Clonidine; Electrophoresis, Polyacrylamide Gel; Female; Histocytochemistry; Infla | 1975 |
Spinal opioid analgesic effects are enhanced in a model of unilateral inflammation/hyperalgesia: possible involvement of noradrenergic mechanisms.
Topics: Adrenergic alpha-Antagonists; Animals; Carrageenan; Clonidine; Enkephalins; Hyperalgesia; Inflammati | 1991 |
Effects of an alpha-2 adrenoceptor agonist on angiotensin converting enzyme inhibitor-induced hypotension and potentiated allergen-evoked inflammatory skin responses.
Topics: Adrenergic alpha-Agonists; Allergens; Angiotensin-Converting Enzyme Inhibitors; Animals; Blood Press | 1988 |
Effects of clonidine on the dermal inflammatory cell response of experimental toxic and allergic contact reactions and intradermal hypersensitivity.
Topics: Animals; Cell Movement; Clonidine; Croton Oil; Dermatitis, Contact; Drug Hypersensitivity; Female; G | 1987 |
Leukocyte chemotaxis in vivo. II. Analysis of the selective inhibition of neutrophil or mononuclear cell accumulation.
Topics: Animals; Bucladesine; Carrageenan; Chemotaxis; Chloroquine; Chlorpromazine; Chromium Radioisotopes; | 1974 |