clonidine has been researched along with Inguinal Hernia in 16 studies
Clonidine: An imidazoline sympatholytic agent that stimulates ALPHA-2 ADRENERGIC RECEPTORS and central IMIDAZOLINE RECEPTORS. It is commonly used in the management of HYPERTENSION.
clonidine (amino form) : A clonidine that is 4,5-dihydro-1H-imidazol-2-amine in which one of the amino hydrogens is replaced by a 2,6-dichlorophenyl group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Tizanidine is a centrally acting α2-agonist with muscle relaxant properties." | 6.82 | Tizanidine for the management of acute postoperative pain after inguinal hernia repair: A placebo-controlled double-blind trial. ( Akkaya, T; Caparlar, C; Kulaçoğlu, H; Mercan, U; Yazicioğlu, D, 2016) |
| "We conclude that for elective inguinal hernia repair, postoperative analgesia obtained by bupivacaine wound infiltration was not improved by the addition of clonidine 150 micrograms." | 6.68 | Does the addition of clonidine affect duration of analgesia of bupivacaine wound infiltration in inguinal hernia surgery? ( Eckersall, S; Elliott, S; Fligelstone, L; Jothilingam, S, 1997) |
| "We conducted a controlled, prospective study of clonidine in caudal anaesthesia in 60 children, aged 1-10 years, undergoing elective inguinal hernia repair." | 5.12 | Clonidine addition prolongs the duration of caudal analgesia. ( Korkmaz, F; Solak, M; Toker, K; Yildiz, TS, 2006) |
| "Forty-four children aged 1-5 years consecutively scheduled for inguinal hernia repair, hydrocele repair or orchidopexy were randomly assigned to receive a caudal injection of either S(+)-ketamine 1 mg x kg(-1) (group K) or S(+)-ketamine 0." | 5.11 | Caudal analgesia in children: S(+)-ketamine vs S(+)-ketamine plus clonidine. ( Almenrader, N; Canneti, A; Haiberger, R; Passariello, M; Pietropaoli, P; Rubeo, L, 2004) |
| "Using a prospective, randomized, observer-blinded study design, 40 patients, aged 1-7 years, who were undergoing elective surgery for inguinal hernia repair or orchidopexy, were randomly allocated to receive either a caudal block (group C: n = 20; ropivacaine 0." | 5.10 | Spinal versus peripheral effects of adjunct clonidine: comparison of the analgesic effect of a ropivacaine-clonidine mixture when administered as a caudal or ilioinguinal-iliohypogastric nerve blockade for inguinal surgery in children. ( Conio, A; De Negri, P; Eksborg, S; Ivani, G; Lönnqvist, PA, 2002) |
| "Tizanidine is a centrally acting α2-agonist with muscle relaxant properties." | 2.82 | Tizanidine for the management of acute postoperative pain after inguinal hernia repair: A placebo-controlled double-blind trial. ( Akkaya, T; Caparlar, C; Kulaçoğlu, H; Mercan, U; Yazicioğlu, D, 2016) |
| "Clonidine has the potential to significantly prolong the duration of caudal epidural anesthesia." | 2.76 | Effect of epidural clonidine on minimum local anesthetic concentration (ED50) of levobupivacaine for caudal block in children. ( Alberighi, OD; Disma, N; Frawley, G; Mameli, L; Montobbio, G; Pistorio, A; Tuo, P, 2011) |
| " We randomized 45 patients to 3 groups receiving intrathecal hyperbaric bupivacaine 6 mg combined with saline (Group B), clonidine 15 micro g (Group BC15), or clonidine 30 micro g (Group BC30); all solutions were diluted with saline to 3 mL." | 2.71 | Clonidine combined with small-dose bupivacaine during spinal anesthesia for inguinal herniorrhaphy: a randomized double-blinded study. ( Axelsson, K; Dobrydnjov, I; Gupta, A; Holmström, B; Klockhoff, H; Matthiesen, P; Thörn, SE, 2003) |
| "We conclude that for elective inguinal hernia repair, postoperative analgesia obtained by bupivacaine wound infiltration was not improved by the addition of clonidine 150 micrograms." | 2.68 | Does the addition of clonidine affect duration of analgesia of bupivacaine wound infiltration in inguinal hernia surgery? ( Eckersall, S; Elliott, S; Fligelstone, L; Jothilingam, S, 1997) |
| "Awake regional anaesthesia for inguinal hernia repair in former preterm infants is suggested to avoid life-threatening respiratory complications known to occur after general anaesthesia." | 1.31 | Apnoea in a former preterm infant after caudal bupivacaine with clonidine for inguinal herniorrhaphy. ( Fellmann, C; Gerber, AC; Weiss, M, 2002) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (12.50) | 18.2507 |
| 2000's | 12 (75.00) | 29.6817 |
| 2010's | 2 (12.50) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Yazicioğlu, D | 1 |
| Caparlar, C | 1 |
| Akkaya, T | 1 |
| Mercan, U | 1 |
| Kulaçoğlu, H | 1 |
| Rakesh, SV | 1 |
| Rajeev, S | 1 |
| Batra, YK | 1 |
| Rao, KL | 1 |
| Disma, N | 1 |
| Frawley, G | 1 |
| Mameli, L | 1 |
| Pistorio, A | 1 |
| Alberighi, OD | 1 |
| Montobbio, G | 1 |
| Tuo, P | 1 |
| Fellmann, C | 1 |
| Gerber, AC | 1 |
| Weiss, M | 1 |
| Ivani, G | 1 |
| Conio, A | 1 |
| De Negri, P | 1 |
| Eksborg, S | 1 |
| Lönnqvist, PA | 1 |
| Dobrydnjov, I | 1 |
| Axelsson, K | 1 |
| Thörn, SE | 1 |
| Matthiesen, P | 1 |
| Klockhoff, H | 1 |
| Holmström, B | 1 |
| Gupta, A | 1 |
| Hussain, AS | 1 |
| Siddiqui, MS | 1 |
| Hamdard, F | 1 |
| Mayhew, JF | 1 |
| Rochette, A | 2 |
| Raux, O | 2 |
| Troncin, R | 2 |
| Dadure, C | 2 |
| Verdier, R | 1 |
| Capdevila, X | 2 |
| Joshi, W | 1 |
| Connelly, NR | 1 |
| Freeman, K | 1 |
| Reuben, SS | 1 |
| Passariello, M | 1 |
| Almenrader, N | 1 |
| Canneti, A | 1 |
| Rubeo, L | 1 |
| Haiberger, R | 1 |
| Pietropaoli, P | 1 |
| Galante, D | 1 |
| Beaussier, M | 1 |
| Weickmans, H | 1 |
| Abdelhalim, Z | 1 |
| Lienhart, A | 1 |
| Lubrano, JF | 1 |
| Barbotte, E | 1 |
| Yildiz, TS | 1 |
| Korkmaz, F | 1 |
| Solak, M | 1 |
| Toker, K | 1 |
| Elliott, S | 1 |
| Eckersall, S | 1 |
| Fligelstone, L | 1 |
| Jothilingam, S | 1 |
| Breschan, C | 1 |
| Krumpholz, R | 1 |
| Likar, R | 1 |
| Kraschl, R | 1 |
| Schalk, HV | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Investigation of the Effectiveness of Tizanidine on Pain After Herniorrhaphy[NCT02016443] | Phase 4 | 30 participants (Actual) | Interventional | 2013-11-30 | Completed | ||
| Preemptive Single Dose Tizanidine and Ultrasound Guided Superficial Cervical Block on Pain After Thyroidectomy[NCT02725359] | Phase 4 | 60 participants (Actual) | Interventional | 2016-04-30 | Completed | ||
| ROPIVACAINE WITH CLONIDINE FOR PEDIATRIC RECTUS SHEATH BLOCKS- THE MAGIC COMBINATION? - A Double Blinded Prospective Study[NCT02439281] | 50 participants (Actual) | Interventional | 2015-05-31 | Terminated (stopped due to The patients were discharged on the day of the surgery.) | |||
| Neonatal Spinal Anesthesia: Effects of the Addition of Clonidine[NCT01075490] | Phase 4 | 120 participants (Anticipated) | Interventional | 2006-11-30 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Numeric Rating Pain Scores ( 0-10), will be obtained every 2 hours after PACU discharge up to 18 hours or until hospital discharge, whichever occurs first. The pain score of 0, means no pain, is a good outcome , and a pain score of 10 is excruciating pain, a very bad outcome. The average of these scores will be evaluated.The pain scores will not longer be documented after the numbness went away. (NCT02439281)
Timeframe: Logistic regression of the 4 th pain score assessment
| Intervention | units on a scale (Median) |
|---|---|
| Ropivacaine Group | 2 |
| Ropivacaine/ Clonidine Group | 1.5 |
The investigators hypothesize that patient postoperative anxiety scores are lower in the Ropivacaine/Clonidine group and postoperative anxiety scores decrease more in Ropivacaine /Clonidine Group, than in Ropivacaine Group. (NCT02439281)
Timeframe: 6 hours after block placement
| Intervention | units on a scale (Median) |
|---|---|
| Ropivacaine Group | 30 |
| Ropivacaine/ Clonidine Group | 29 |
The investigators expect no difference in incidence of complications (e.g. oversedation, hypotension, bradycardia episodes, etc.). (NCT02439281)
Timeframe: until study completion
| Intervention | Participants (Count of Participants) |
|---|---|
| Ropivacaine/ Clonidine Group | 1 |
| Ropivacaine Group | 1 |
The investigators hypothesize that rectus sheath injections with ropivacaine/ clonidine would result in longer duration of analgesia and decreased pain scores compared to ropivacaine alone. (NCT02439281)
Timeframe: indicated by the first request for pain medication at umbilicus site
| Intervention | minutes (Median) |
|---|---|
| Ropivacaine/ Clonidine Group | 230 |
| Ropivacaine Group | 240 |
The investigators hypothesize that rectus sheath injections with ropivacaine and clonidine result in longer duration of sensory block (paresthesia) compared to ropivacaine alone. (NCT02439281)
Timeframe: Indicated by return of normal sensation (expected average of 12 hours after block placement).
| Intervention | minutes (Median) |
|---|---|
| Ropivacaine/ Clonidine Group | 823.5 |
| Ropivacaine Group | 540 |
Total intravenous morphine equivalents mg/kg (NCT02439281)
Timeframe: 18 hours after surgery
| Intervention | mg/kg (Median) |
|---|---|
| Ropivacaine/ Clonidine Group | 0.20 |
| Ropivacaine Group | 0.22 |
The investigators hypothesize that rectus sheath injections with ropivacaine/ clonidine would result in better satisfaction with pain control. (NCT02439281)
Timeframe: Prior to hospital discharge (up to 24 hours after surgery)
| Intervention | units on a scale (Median) |
|---|---|
| Ropivacaine/ Clonidine Group | 9 |
| Ropivacaine Group | 9 |
11 trials available for clonidine and Inguinal Hernia
| Article | Year |
|---|---|
Tizanidine for the management of acute postoperative pain after inguinal hernia repair: A placebo-controlled double-blind trial.
Topics: Acute Pain; Adult; Aged; Analgesics; Clonidine; Double-Blind Method; Female; Hernia, Inguinal; Herni | 2016 |
Tizanidine for the management of acute postoperative pain after inguinal hernia repair: A placebo-controlled double-blind trial.
Topics: Acute Pain; Adult; Aged; Analgesics; Clonidine; Double-Blind Method; Female; Hernia, Inguinal; Herni | 2016 |
Tizanidine for the management of acute postoperative pain after inguinal hernia repair: A placebo-controlled double-blind trial.
Topics: Acute Pain; Adult; Aged; Analgesics; Clonidine; Double-Blind Method; Female; Hernia, Inguinal; Herni | 2016 |
Tizanidine for the management of acute postoperative pain after inguinal hernia repair: A placebo-controlled double-blind trial.
Topics: Acute Pain; Adult; Aged; Analgesics; Clonidine; Double-Blind Method; Female; Hernia, Inguinal; Herni | 2016 |
Effect of epidural clonidine on minimum local anesthetic concentration (ED50) of levobupivacaine for caudal block in children.
Topics: Adjuvants, Anesthesia; Adrenergic alpha-Agonists; Analgesia, Epidural; Anesthesia, Caudal; Anestheti | 2011 |
Spinal versus peripheral effects of adjunct clonidine: comparison of the analgesic effect of a ropivacaine-clonidine mixture when administered as a caudal or ilioinguinal-iliohypogastric nerve blockade for inguinal surgery in children.
Topics: Amides; Analgesia; Anesthesia, Caudal; Anesthetics, Combined; Anesthetics, Local; Child; Child, Pres | 2002 |
Clonidine combined with small-dose bupivacaine during spinal anesthesia for inguinal herniorrhaphy: a randomized double-blinded study.
Topics: Adrenergic alpha-Agonists; Adult; Anesthesia, General; Anesthesia, Spinal; Anesthetics, Local; Bupiv | 2003 |
Clonidine prolongs spinal anesthesia in newborns: a prospective dose-ranging study.
Topics: Adrenergic alpha-Agonists; Anesthesia, Spinal; Anesthetics, Local; Bupivacaine; Clonidine; Dose-Resp | 2004 |
Analgesic effect of clonidine added to bupivacaine 0.125% in paediatric caudal blockade.
Topics: Adrenergic alpha-Agonists; Analgesics; Anesthesia, Caudal; Anesthetics, Local; Bupivacaine; Child, P | 2004 |
Caudal analgesia in children: S(+)-ketamine vs S(+)-ketamine plus clonidine.
Topics: Adrenergic alpha-Agonists; Analgesia; Anesthesia Recovery Period; Anesthesia, Caudal; Anesthetics, D | 2004 |
Inguinal herniorrhaphy under monitored anesthesia care with ilioinguinal-iliohypogastric block: the impact of adding clonidine to ropivacaine.
Topics: Adrenergic alpha-Agonists; Adult; Aged; Amides; Anesthetics, Local; Clonidine; Double-Blind Method; | 2005 |
Clonidine added to bupivacaine in neonatal spinal anesthesia: a prospective comparison in 124 preterm and term infants.
Topics: Adjuvants, Anesthesia; Analgesics; Anesthesia, Spinal; Anesthetics, Local; Bupivacaine; Clonidine; H | 2005 |
Clonidine added to bupivacaine in neonatal spinal anesthesia: a prospective comparison in 124 preterm and term infants.
Topics: Adjuvants, Anesthesia; Analgesics; Anesthesia, Spinal; Anesthetics, Local; Bupivacaine; Clonidine; H | 2005 |
Clonidine added to bupivacaine in neonatal spinal anesthesia: a prospective comparison in 124 preterm and term infants.
Topics: Adjuvants, Anesthesia; Analgesics; Anesthesia, Spinal; Anesthetics, Local; Bupivacaine; Clonidine; H | 2005 |
Clonidine added to bupivacaine in neonatal spinal anesthesia: a prospective comparison in 124 preterm and term infants.
Topics: Adjuvants, Anesthesia; Analgesics; Anesthesia, Spinal; Anesthetics, Local; Bupivacaine; Clonidine; H | 2005 |
Clonidine addition prolongs the duration of caudal analgesia.
Topics: Adjuvants, Anesthesia; Anesthesia, Caudal; Anesthetics, Local; Bupivacaine; Child; Child, Preschool; | 2006 |
Does the addition of clonidine affect duration of analgesia of bupivacaine wound infiltration in inguinal hernia surgery?
Topics: Adrenergic alpha-Agonists; Aged; Analgesia; Anesthetics, Local; Bupivacaine; Clonidine; Double-Blind | 1997 |
5 other studies available for clonidine and Inguinal Hernia
| Article | Year |
|---|---|
Cephalad migration of intrathecal clonidine in an infant undergoing bilateral herniorrhaphy.
Topics: Adrenergic alpha-Agonists; Clonidine; Hernia, Inguinal; Humans; Infant; Injections, Spinal; Intraope | 2009 |
Apnoea in a former preterm infant after caudal bupivacaine with clonidine for inguinal herniorrhaphy.
Topics: Anesthesia, Caudal; Anesthetics, Combined; Apnea; Bupivacaine; Clonidine; Hernia, Inguinal; Humans; | 2002 |
Postoperative apnoea in an ex-premature infant: is it only related to clonidine?
Topics: Analgesics; Anesthesia, Caudal; Anesthesia, General; Anesthetics, Local; Apnea; Bupivacaine; Clonidi | 2003 |
Preoperative apnea in a preterm infant after caudal block with ropivacaine and clonidine.
Topics: Amides; Analgesics; Anesthesia, Caudal; Anesthetics, Local; Apnea; Bradycardia; Clonidine; Hernia, I | 2005 |
Can a dose of 2microg.kg(-1) caudal clonidine cause respiratory depression in neonates?
Topics: Adrenergic alpha-Agonists; Amides; Anesthesia, Caudal; Anesthesia, Inhalation; Anesthetics, Local; A | 1999 |