clonidine has been researched along with Hypoxia in 22 studies
Clonidine: An imidazoline sympatholytic agent that stimulates ALPHA-2 ADRENERGIC RECEPTORS and central IMIDAZOLINE RECEPTORS. It is commonly used in the management of HYPERTENSION.
clonidine (amino form) : A clonidine that is 4,5-dihydro-1H-imidazol-2-amine in which one of the amino hydrogens is replaced by a 2,6-dichlorophenyl group.
Hypoxia: Sub-optimal OXYGEN levels in the ambient air of living organisms.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Hypoxia or hypercapnia elicits cardiovascular responses associated with increased plasma catecholamine concentrations, whereas clonidine, an alpha(2)- adrenergic agonist, decreases plasma catecholamine concentrations." | 7.69 | Clonidine modulation of hemodynamic and catecholamine responses associated with hypoxia or hypercapnia in dogs. ( Naito, H; Nishikawa, T, 1996) |
| " These results provide further evidence that alpha(2)-adrenergic receptor activation shortly after perinatal hypoxia-ischemia can promote neural recovery, but highlight the complex dose-response of exogenous therapy." | 5.35 | Partial neuroprotection with low-dose infusion of the alpha2-adrenergic receptor agonist clonidine after severe hypoxia in preterm fetal sheep. ( Bennet, L; Dean, JM; George, S; Gunn, AJ; Mallard, C; Naylor, AS, 2008) |
| "In a previous study, we showed that clonidine, an α₂-adrenoceptor agonist, administered prior to hypoxia improves post-hypoxic contractility (PC) and endothelium-dependent dilatation (PED) in isolated young rat aortas." | 3.78 | Ageing influences the effect of pre-hypoxic administration of clonidine, an alpha₂-adrenoceptor agonist, on post-hypoxic vasomotricity. ( De Kock, M; Gourdin, MJ; Jamart, J; Ponchau, O, 2012) |
| "Systemic dexmedetomidine (DXM) attenuates the cerebral vasodilation induced by hypercapnia and decreases the cerebral blood flow response to hypoxia." | 3.70 | Intrathecal dexmedetomidine attenuates hypercapnic but not hypoxic cerebral vasodilation in anesthetized rabbits. ( Dohi, S; Iida, H; Iida, M; Takenaka, M, 2000) |
| "Hypoxia or hypercapnia elicits cardiovascular responses associated with increased plasma catecholamine concentrations, whereas clonidine, an alpha(2)- adrenergic agonist, decreases plasma catecholamine concentrations." | 3.69 | Clonidine modulation of hemodynamic and catecholamine responses associated with hypoxia or hypercapnia in dogs. ( Naito, H; Nishikawa, T, 1996) |
| "This study was designed to evaluate hypoxemia and platelet aggregation in man following intravenous administration of clonidine." | 2.67 | Intravenous clonidine does not promote hypoxemia or platelet aggregation in man. ( De Kock, M; Gouverneur, JM; Henin, D; Singelyn, F, 1993) |
| " These results provide further evidence that alpha(2)-adrenergic receptor activation shortly after perinatal hypoxia-ischemia can promote neural recovery, but highlight the complex dose-response of exogenous therapy." | 1.35 | Partial neuroprotection with low-dose infusion of the alpha2-adrenergic receptor agonist clonidine after severe hypoxia in preterm fetal sheep. ( Bennet, L; Dean, JM; George, S; Gunn, AJ; Mallard, C; Naylor, AS, 2008) |
| "In Clonidine pretreated hypoxic group, the hypoxia-induced increased expression of pro-apoptotic proteins Bad and Bax was prevented in all the three fractions." | 1.35 | Effect of hypoxia on expression of apoptotic proteins in nuclear, mitochondrial and cytosolic fractions of the cerebral cortex of newborn piglets: the role of nuclear Ca++ -influx. ( Ashraf, QM; Delivoria-Papadopoulos, M; Mishra, OP, 2008) |
| "Clonidine-induced hypoxemia was inhibited in a dose-dependent manner by the alpha-2 adrenergic antagonist idazoxan (0." | 1.27 | Intravenous clonidine produces hypoxemia by a peripheral alpha-2 adrenergic mechanism. ( Eisenach, JC, 1988) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (18.18) | 18.7374 |
| 1990's | 8 (36.36) | 18.2507 |
| 2000's | 7 (31.82) | 29.6817 |
| 2010's | 3 (13.64) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Scalzo, RL | 2 |
| Peltonen, GL | 2 |
| Binns, SE | 1 |
| Klochak, AL | 1 |
| Szallar, SE | 1 |
| Wood, LM | 1 |
| Larson, DG | 2 |
| Luckasen, GJ | 2 |
| Irwin, D | 2 |
| Schroeder, T | 2 |
| Hamilton, KL | 2 |
| Bell, C | 2 |
| Dean, JM | 1 |
| George, S | 1 |
| Naylor, AS | 1 |
| Mallard, C | 1 |
| Gunn, AJ | 1 |
| Bennet, L | 1 |
| Schweder, MM | 1 |
| Gourdin, MJ | 1 |
| Ponchau, O | 1 |
| Jamart, J | 1 |
| De Kock, M | 2 |
| Delivoria-Papadopoulos, M | 3 |
| Mishra, OP | 3 |
| Hornick, K | 1 |
| Chang, E | 1 |
| Zubrow, AB | 1 |
| Ashraf, QM | 1 |
| Henin, D | 1 |
| Singelyn, F | 1 |
| Gouverneur, JM | 1 |
| Nishikawa, T | 1 |
| Naito, H | 1 |
| Foo, IT | 1 |
| Warren, PM | 1 |
| Drummond, GB | 1 |
| Bickler, PE | 1 |
| Hansen, BM | 1 |
| Gao, H | 1 |
| Korthuis, RJ | 1 |
| Benoit, JN | 1 |
| Celly, CS | 1 |
| McDonell, WN | 1 |
| Black, WD | 1 |
| Young, SS | 1 |
| Ernsberger, P | 2 |
| Kou, YR | 1 |
| Prabhakar, NR | 1 |
| Thomas, AJ | 1 |
| Erokwu, BO | 1 |
| Yamamoto, BK | 1 |
| Bishara, O | 1 |
| Strohl, KP | 1 |
| Takenaka, M | 1 |
| Iida, H | 1 |
| Iida, M | 1 |
| Dohi, S | 1 |
| O'Halloran, KD | 1 |
| Herman, JK | 1 |
| Bisgard, GE | 1 |
| Narchi, P | 1 |
| Benhamou, D | 1 |
| Hamza, J | 1 |
| Bouaziz, H | 1 |
| Garty, M | 1 |
| Ben-Zvi, Z | 1 |
| Hurwitz, A | 1 |
| Eisenach, JC | 1 |
| Abrahamsen, J | 1 |
| Nedergaard, OA | 1 |
| Brown, R | 1 |
| Engel, J | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Anxiety-mediated Impairments in Large Elastic Artery Function and the Autonomic Nervous System[NCT03109795] | Phase 4 | 30 participants (Actual) | Interventional | 2017-04-10 | Terminated (stopped due to Funding ended) | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
4 trials available for clonidine and Hypoxia
| Article | Year |
|---|---|
Sympathetic inhibition attenuates hypoxia induced insulin resistance in healthy adult humans.
Topics: Adult; Blood Glucose; Clonidine; Humans; Hypoxia; Insulin Resistance; Male; Sympathetic Nervous Syst | 2012 |
Intravenous clonidine does not promote hypoxemia or platelet aggregation in man.
Topics: Aged; Aged, 80 and over; Clonidine; Double-Blind Method; Female; Hip Prosthesis; Humans; Hypoxia; In | 1993 |
Influence of oral clonidine on the ventilatory response to acute and sustained isocapnic hypoxia in human males.
Topics: Acute Disease; Administration, Oral; Adrenergic alpha-Agonists; Adult; Carbon Dioxide; Clonidine; Hu | 1996 |
Ventilatory effects of epidural clonidine during the first 3 hours after caesarean section.
Topics: Analgesia, Epidural; Analgesia, Obstetrical; Apnea; Cesarean Section; Clonidine; Double-Blind Method | 1992 |
18 other studies available for clonidine and Hypoxia
| Article | Year |
|---|---|
The Effects of Sympathetic Inhibition on Metabolic and Cardiopulmonary Responses to Exercise in Hypoxic Conditions.
Topics: Adult; Blood Pressure; Clonidine; Exercise; Exercise Test; Heart Rate; Humans; Hypoxia; Male; Oxyhem | 2015 |
Partial neuroprotection with low-dose infusion of the alpha2-adrenergic receptor agonist clonidine after severe hypoxia in preterm fetal sheep.
Topics: Adrenergic alpha-Agonists; Animals; Brain; Clonidine; Disease Models, Animal; Dose-Response Relation | 2008 |
Ageing influences the effect of pre-hypoxic administration of clonidine, an alpha₂-adrenoceptor agonist, on post-hypoxic vasomotricity.
Topics: Adrenergic alpha-2 Receptor Agonists; Aging; Animals; Aorta, Thoracic; Clonidine; Endothelium, Vascu | 2012 |
Mechanism of activation of caspase-9 and caspase-3 during hypoxia in the cerebral cortex of newborn piglets: the role of nuclear Ca2+ -influx.
Topics: Animals; Animals, Newborn; Calcium; Caspase 3; Caspase 9; Cell Nucleus; Cerebral Cortex; Clonidine; | 2007 |
Mechanism of Ca(2+)/calmodulin-dependent protein kinase IV activation and of cyclic AMP response element binding protein phosphorylation during hypoxia in the cerebral cortex of newborn piglets.
Topics: Adenosine Triphosphate; Adrenergic alpha-Agonists; Animals; Animals, Newborn; Calcium-Calmodulin-Dep | 2007 |
Effect of hypoxia on expression of apoptotic proteins in nuclear, mitochondrial and cytosolic fractions of the cerebral cortex of newborn piglets: the role of nuclear Ca++ -influx.
Topics: Adenosine Triphosphate; Adrenergic alpha-Agonists; Animals; Animals, Newborn; Apoptosis Regulatory P | 2008 |
Clonidine modulation of hemodynamic and catecholamine responses associated with hypoxia or hypercapnia in dogs.
Topics: Adrenergic alpha-Agonists; Animals; Catecholamines; Clonidine; Dogs; Female; Hemodynamics; Hypercapn | 1996 |
Alpha 2-adrenergic agonists reduce glutamate release and glutamate receptor-mediated calcium changes in hippocampal slices during hypoxia.
Topics: Adrenergic alpha-Agonists; Animals; Calcium; Clonidine; Dose-Response Relationship, Drug; Glutamic A | 1996 |
Hypoxia/reoxygenation selectively impairs alpha 1b-adrenoceptor function in small mesenteric arteries.
Topics: Adrenergic alpha-Antagonists; Aerobiosis; Animals; Catalase; Clonidine; Dioxanes; Hypoxia; In Vitro | 1996 |
Cardiopulmonary effects of clonidine, diazepam and the peripheral alpha 2 adrenoceptor agonist ST-91 in conscious sheep.
Topics: Adjuvants, Anesthesia; Adrenergic alpha-Agonists; Animals; Clonidine; Diazepam; Female; Hemodynamics | 1997 |
Carotid body I1-imidazoline receptors: binding, visualization and modulatory function.
Topics: Adrenergic alpha-Agonists; Affinity Labels; Animals; Autoradiography; Carotid Body; Cats; Clonidine; | 1998 |
Alterations in respiratory behavior, brain neurochemistry and receptor density induced by pharmacologic suppression of sleep in the neonatal period.
Topics: Adrenergic alpha-Agonists; Aging; Animals; Animals, Newborn; Animals, Suckling; Brain; Brain Chemist | 2000 |
Intrathecal dexmedetomidine attenuates hypercapnic but not hypoxic cerebral vasodilation in anesthetized rabbits.
Topics: Adjuvants, Anesthesia; Administration, Topical; Adrenergic alpha-Agonists; Adrenergic alpha-Antagoni | 2000 |
Ventilatory effects of alpha2-adrenoceptor blockade in awake goats.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Benzazepines; Blood Pressure; Caro | 2001 |
Interaction of clonidine and morphine with lidocaine in mice and rats.
Topics: Animals; Blood Gas Analysis; Clonidine; Dose-Response Relationship, Drug; Drug Synergism; Hypoxia; L | 1989 |
Intravenous clonidine produces hypoxemia by a peripheral alpha-2 adrenergic mechanism.
Topics: Animals; Clonidine; Dose-Response Relationship, Drug; Female; Hemodynamics; Hypoxia; Injections, Int | 1988 |
Accumulation of 3H-adrenaline by rabbit aorta.
Topics: Animals; Aorta; Catechol O-Methyltransferase Inhibitors; Clonidine; Cocaine; Desipramine; Epinephrin | 1985 |
Evidence for catecholamine involvement in the suppression of locomotor activity due to hypoxia.
Topics: Amphetamine; Animals; Apomorphine; Clonidine; Dihydroxyphenylalanine; Female; Hypoxia; Mice; Motor A | 1973 |