clonidine has been researched along with Hypothyroidism in 19 studies
Clonidine: An imidazoline sympatholytic agent that stimulates ALPHA-2 ADRENERGIC RECEPTORS and central IMIDAZOLINE RECEPTORS. It is commonly used in the management of HYPERTENSION.
clonidine (amino form) : A clonidine that is 4,5-dihydro-1H-imidazol-2-amine in which one of the amino hydrogens is replaced by a 2,6-dichlorophenyl group.
Hypothyroidism: A syndrome that results from abnormally low secretion of THYROID HORMONES from the THYROID GLAND, leading to a decrease in BASAL METABOLIC RATE. In its most severe form, there is accumulation of MUCOPOLYSACCHARIDES in the SKIN and EDEMA, known as MYXEDEMA. It may be primary or secondary due to other pituitary disease, or hypothalamic dysfunction.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Adrenoceptor-mediated responses of the cardiovascular system during propylthiouracil-induced hypothyroidism were investigated." | 7.66 | Changes of adrenoceptor-mediated responses in the pithed rat during propylthiouracil-induced hypothyroidism. ( Borowski, E; Gross, G; Schümann, HJ, 1979) |
| "Clonidine-induced hypoactivity was studied in rats made neonatally hypo- and hyperthyroid (PTU or T4 administered between 1-27 days postnatally) as an indication of central presynaptic alpha 2-adrenoceptor function." | 3.67 | Effects of thyroid status on clonidine-induced hypoactivity responses in the developing rat. ( Atterwill, CK; Heal, DJ; Smith, SD, 1984) |
| " Repeated triiodothyronine (T3) administration to rats (100 micrograms/kg X 14 days: hyperthyroid) caused an 18% increase in striatal beta-adrenoceptors as shown by [3H]-dihydroalprenolol binding with no change in membranes from cerebral cortex or hypothalamus." | 3.67 | Effects of thyroid status on presynaptic alpha 2-adrenoceptor function and beta-adrenoceptor binding in the rat brain. ( Atkinson, DJ; Atterwill, CK; Bunn, SJ; Heal, DJ; Smith, SL, 1984) |
| " Four groups of rats: hypothyroid, hyperthyroid, thyroxine (0." | 3.67 | The effect of hyperthyroidism and hypothyroidism on alpha 1- and alpha 2-adrenergic responsiveness in rat aortic smooth muscle. ( Cheema, IR; Peoples, B; Rahmani, MA; Riley, SR; Sen, S, 1987) |
| " In order to find out whether similar changes exist in the central nervous system, we investigated adrenoceptor-mediated responses in the rat brain cortex during propylthiouracil-induced hypothyroidism." | 3.66 | Effects of thyroid hormone deficiency on pre- and postsynaptic noradrenergic mechanisms in the rat cerebral cortex. ( Brodde, OE; Gross, G; Schümann, HJ, 1980) |
| "Adrenoceptor-mediated responses of the cardiovascular system during propylthiouracil-induced hypothyroidism were investigated." | 3.66 | Changes of adrenoceptor-mediated responses in the pithed rat during propylthiouracil-induced hypothyroidism. ( Borowski, E; Gross, G; Schümann, HJ, 1979) |
| "Hypocalcemia was detected in five of the 30 thalassemic patients: hypoparathyroidism was diagnosed in two of the five and rickets in the other three." | 2.69 | Bone mineral density in prepubertal children with beta-thalassemia: correlation with growth and hormonal data. ( Abdel Fattah, M; Ansari, BM; El Banna, N; ElZalabani, MM; Soliman, AT, 1998) |
| "Clonidine did not cause any inotropic change in the euthyroid rat atrium." | 1.27 | Changes in the effects of clonidine on left atrium and hindlimb vasculature of rats in various thyroid states. A study of the responsiveness of alpha 2-adrenoceptors in the cardiovascular system. ( Nakashima, M; Oguro, K; Ohguchi, S; Sotobata, I, 1984) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 13 (68.42) | 18.7374 |
| 1990's | 4 (21.05) | 18.2507 |
| 2000's | 2 (10.53) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ghannoum, JE | 1 |
| Odingo, NA | 1 |
| Provost, N | 1 |
| Ohguchi, S | 2 |
| Sotobata, I | 1 |
| Oguro, K | 2 |
| Nakashima, M | 2 |
| Heal, DJ | 2 |
| Smith, SD | 1 |
| Atterwill, CK | 2 |
| Gross, G | 3 |
| Schümann, HJ | 3 |
| Brodde, OE | 1 |
| Bunn, SJ | 1 |
| Atkinson, DJ | 1 |
| Smith, SL | 1 |
| Molinero, P | 1 |
| Osuna, C | 1 |
| Guerrero, JM | 1 |
| Ning, C | 1 |
| Wei, H | 1 |
| Shu, D | 1 |
| Hu, XF | 1 |
| Tao, DD | 1 |
| Lin, HH | 1 |
| Wang, S | 1 |
| Wang, MT | 1 |
| Del Rio, G | 1 |
| Zizzo, G | 1 |
| Marrama, P | 1 |
| Venneri, MG | 1 |
| Della Casa, L | 1 |
| Velardo, A | 1 |
| Soliman, AT | 1 |
| El Banna, N | 1 |
| Abdel Fattah, M | 1 |
| ElZalabani, MM | 1 |
| Ansari, BM | 1 |
| Wajnrajch, MP | 1 |
| Gertner, JM | 1 |
| Huma, Z | 1 |
| Popovic, J | 1 |
| Lin, K | 1 |
| Verlander, PC | 1 |
| Batish, SD | 1 |
| Giampietro, PF | 1 |
| Davis, JG | 1 |
| New, MI | 1 |
| Auerbach, AD | 1 |
| Männistö, PT | 1 |
| Ranta, T | 1 |
| Borowski, E | 1 |
| Nomura, H | 1 |
| Izuhara, K | 1 |
| Nomura, T | 1 |
| Kodama, M | 1 |
| Sugiura, N | 1 |
| Tachibana, M | 1 |
| Hagino, Y | 1 |
| Rahmani, MA | 1 |
| Cheema, IR | 1 |
| Sen, S | 1 |
| Peoples, B | 1 |
| Riley, SR | 1 |
| García-Sáinz, JA | 1 |
| Contreras-Rodríguez, JL | 1 |
| De Gennaro, V | 1 |
| Cella, SG | 1 |
| Bassetti, M | 1 |
| Rizzi, R | 1 |
| Cocchi, D | 1 |
| Muller, EE | 1 |
| Ho, KY | 1 |
| Evans, WS | 1 |
| Thorner, MO | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Denosumab Versus Zoledronic Acid for Patients With Beta-Thalassemia Major-Induced Osteoporosis[NCT03040765] | Phase 3 | 17 participants (Actual) | Interventional | 2018-05-14 | Terminated (stopped due to failed to recruit eligible subjects) | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for clonidine and Hypothyroidism
| Article | Year |
|---|---|
Disorders of prolactin and growth hormone secretion.
Topics: Acromegaly; Arginine; Clonidine; Dwarfism; Female; Glucose Tolerance Test; Growth Hormone; Growth Ho | 1985 |
1 trial available for clonidine and Hypothyroidism
| Article | Year |
|---|---|
Bone mineral density in prepubertal children with beta-thalassemia: correlation with growth and hormonal data.
Topics: Absorptiometry, Photon; Adolescent; Adrenocorticotropic Hormone; Age Factors; Alkaline Phosphatase; | 1998 |
17 other studies available for clonidine and Hypothyroidism
| Article | Year |
|---|---|
Clinico-pathologic conference: case 6.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Antihypertensive Agents; Aspirin; Carcinoma, Squamous Cell; | 2009 |
Changes in the effects of clonidine on left atrium and hindlimb vasculature of rats in various thyroid states. A study of the responsiveness of alpha 2-adrenoceptors in the cardiovascular system.
Topics: Animals; Clonidine; Dose-Response Relationship, Drug; Heart Atria; Hindlimb; Hypothyroidism; In Vitr | 1984 |
Effects of thyroid status on clonidine-induced hypoactivity responses in the developing rat.
Topics: Animals; Animals, Newborn; Clonidine; Female; Hyperthyroidism; Hypothyroidism; Male; Motor Activity; | 1984 |
Reduced number of alpha2-adrenoceptors in cortical brain membranes of hypothyroid rats.
Topics: Animals; Brain; Clonidine; Hypothyroidism; Kinetics; Male; Membranes; Propylthiouracil; Rats; Rats, | 1981 |
Effects of thyroid hormone deficiency on pre- and postsynaptic noradrenergic mechanisms in the rat cerebral cortex.
Topics: Animals; Cerebral Cortex; Clonidine; Cyclic AMP; Dose-Response Relationship, Drug; Hypothyroidism; I | 1980 |
Effects of thyroid status on presynaptic alpha 2-adrenoceptor function and beta-adrenoceptor binding in the rat brain.
Topics: Animals; Brain; Clonidine; Dihydroalprenolol; Hyperthyroidism; Hypothyroidism; Rats; Receptors, Adre | 1984 |
Induction of opposite response of hindlimb vasculature to adrenergic agents in hypothyroid rats.
Topics: Acetylcholine; Animals; Blood Pressure; Clonidine; Heart Rate; Hindlimb; Hypothyroidism; In Vitro Te | 1984 |
Type II thyroxine 5'-deiodinase in the rat thymus.
Topics: Animals; Cell Membrane; Clonidine; Female; Hypothyroidism; Iodide Peroxidase; Isoproterenol; Male; M | 1995 |
Clinical significance of multiple hypothalamic-pituitary functions assessment in patients with Turner's syndrome.
Topics: Adolescent; Adult; Child; Child, Preschool; Clonidine; Female; Humans; Hypothalamo-Hypophyseal Syste | 1994 |
Alpha 2-adrenergic activity is normal in patients with thyroid disease.
Topics: Adult; Blood Pressure; Catecholamines; Clonidine; Epinephrine; Female; Humans; Hyperthyroidism; Hypo | 1994 |
Evaluation of growth and hormonal status in patients referred to the International Fanconi Anemia Registry.
Topics: Adolescent; Adult; Anthropometry; Body Height; Child; Child, Preschool; Clonidine; Diabetes Mellitus | 2001 |
Neurotransmitter control of thyrotrophin secretion in hypothyroid rats.
Topics: 5-Hydroxytryptophan; Animals; Apomorphine; Bromocriptine; Clonidine; Ditiocarb; Fenclonine; Hypothyr | 1978 |
Changes of adrenoceptor-mediated responses in the pithed rat during propylthiouracil-induced hypothyroidism.
Topics: Animals; Atropine; Blood Pressure; Bupranolol; Clonidine; Disease Models, Animal; Electric Stimulati | 1979 |
The interaction of alpha- and beta-adrenergic agonists on amylase release from parotid glands of euthyroid and hypothyroid rats.
Topics: Adrenergic alpha-Agonists; Adrenergic beta-Agonists; Amylases; Animals; Bucladesine; Calcium; Clonid | 1986 |
The effect of hyperthyroidism and hypothyroidism on alpha 1- and alpha 2-adrenergic responsiveness in rat aortic smooth muscle.
Topics: Animals; Aorta; Clonidine; Hyperthyroidism; Hypothyroidism; In Vitro Techniques; Male; Muscle Contra | 1987 |
Possible existence of two mechanisms involved in alpha 1-adrenergic action: effect of Sgd 101/75.
Topics: Adrenalectomy; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Calcium; Clonidine; | 1986 |
Impaired growth hormone secretion in neonatal hypothyroid rats: hypothalamic versus pituitary component.
Topics: Animals; Animals, Newborn; Arcuate Nucleus of Hypothalamus; Clonidine; Growth Hormone; Growth Hormon | 1988 |