Page last updated: 2024-10-25

clonidine and Hypotension

clonidine has been researched along with Hypotension in 156 studies

Clonidine: An imidazoline sympatholytic agent that stimulates ALPHA-2 ADRENERGIC RECEPTORS and central IMIDAZOLINE RECEPTORS. It is commonly used in the management of HYPERTENSION.
clonidine (amino form) : A clonidine that is 4,5-dihydro-1H-imidazol-2-amine in which one of the amino hydrogens is replaced by a 2,6-dichlorophenyl group.

Hypotension: Abnormally low BLOOD PRESSURE that can result in inadequate blood flow to the brain and other vital organs. Common symptom is DIZZINESS but greater negative impacts on the body occur when there is prolonged depravation of oxygen and nutrients.

Research Excerpts

ExcerptRelevanceReference
"To determine whether aspirin compared with placebo, and clonidine compared with placebo, alters the risk of perioperative acute kidney injury."9.19Perioperative aspirin and clonidine and risk of acute kidney injury: a randomized clinical trial. ( Acedillo, R; Amir, M; Bergese, S; Biccard, B; Bidgoli, SJ; Cata, JP; Cegarra, V; Chan, MT; Chan, V; Clanchet, Mde N; Cuerden, M; Devereaux, PJ; Dresser, G; Fleischmann, E; Font, A; Forget, P; Garg, AX; Gomez, MF; Jones, PM; Kumar, P; Kurz, A; Leslie, K; Malaga, G; Martinsen, K; Mehra, B; Meyhoff, CS; Mizera, R; Mrkobrada, M; Myles, P; Painter, T; Parikh, CR; Parlow, J; Pasin, L; Robinson, A; Roshanov, PS; Sessler, DI; Srinathan, S; Tiboni, M; Torres, D; VanHelder, T; Villar, JC; Walsh, M; Whitlock, R; Wijeysundera, DN; Yusuf, S, 2014)
"Clonidine premedication prevents tourniquet pain and reduces sympathetic nerve activity."9.11Oral clonidine premedication exacerbates hypotension following tourniquet deflation by inhibiting noradrenaline release. ( Hongo, T; Kim, C; Kobayashi, N; Maruyama, K; Ogawa, R; Takeda, S, 2004)
"8 years) with autistic disorder, diagnosed by DSM-III-R criteria, completed a placebo-controlled, double-blind crossover trial of clonidine."9.07Clonidine treatment of hyperactive and impulsive children with autistic disorder. ( Cook, EH; Fletcher, KE; Jaselskis, CA; Leventhal, BL, 1992)
"Alpha 2-adrenergic receptor changes during antidepressant treatment were studied using 3H-yohimbine binding to human platelet membranes and clonidine-induced hypotension."9.06Alpha 2-adrenergic receptor sensitivity in depressed patients: relation between 3H-yohimbine binding to platelet membranes and clonidine-induced hypotension. ( Gelenberg, AJ; Lydiard, RB; Wolfe, N, 1989)
"Paediatric clonidine poisoning commonly results in bradycardia, hypotension and decreased GCS, but rarely severe or requiring major interventions."8.31Reality of clonidine poisoning in children and adolescents. ( Downes, MA; Duong, C; Isbister, GK; Lovett, C, 2023)
"The agonists of alpha(2)-adrenergic receptors such as clonidine, rilmenidine or monoxidine are known to lower blood pressure (BP) through a reduction of brain sympathetic outflow but their chronic antihypertensive effects in rats with low-renin or high-renin forms of experimental hypertension were not studied yet."8.12Blood pressure reduction induced by chronic intracerebroventricular or peroral clonidine administration in rats with salt-dependent or angiotensin II-dependent hypertension. ( Behuliak, M; Řezáčová, L; Vaněčková, I; Zicha, J, 2022)
"Administration of clonidine during hypotensive sepsis reduced renal sympathetic nerve activity, restored vascular sensitivity to both phenylephrine and angiotensin II, and resulted in better preservation of arterial pressure."7.81Clonidine Restores Pressor Responsiveness to Phenylephrine and Angiotensin II in Ovine Sepsis. ( Bellomo, R; Booth, LC; Evans, RG; Kosaka, J; Lankadeva, YR; May, CN; Quintin, L, 2015)
"Our previous studies showed that chronic ethanol feeding attenuates centrally (clonidine) evoked and potentiates peripherally (hydralazine) evoked hypotension in female rats."7.77Bradykinin B2 receptor-dependent enhancement of enalapril-evoked hypotension in ethanol-fed female rats. ( Abdel-Rahman, AA; El-Mas, MM, 2011)
"A case of severe bradycardia and hypotension associated with concomitant tizanidine and lisinopril therapy is reported."7.76Hypotension and bradycardia associated with concomitant tizanidine and lisinopril therapy. ( Branam, DL; Publow, SW, 2010)
"Clonidine (a mixed alpha2-adrenoceptor and imidazoline I1 receptor agonist)-evoked hypotension was associated with dissimilar reductions in c-jun gene expression in the rostral ventrolateral medulla (RVLM) and the nucleus tractus solitarius (NTS) in normotensive rats."7.73Site-dependent inhibition of neuronal c-jun in the brainstem elicited by imidazoline I1 receptor activation: role in rilmenidine-evoked hypotension. ( Abdel-Rahman, AA; Li, G; Wang, X, 2005)
"To identify cases of clonidine poisoning presenting to a tertiary paediatric hospital and to investigate trends in presentation, outcome and prevention."7.72Clonidine poisoning in children: a recent experience. ( Cranswick, NE; Sinha, Y, 2004)
"To report a case in which significant hypotension occurred after initiation of tizanidine in a patient using the antihypertensive agent lisinopril."7.72Hypotension due to interaction between lisinopril and tizanidine. ( Chang, JB; Chen, JT; Kao, CD; Liao, KK; Shan, DE; Wu, ZA, 2004)
" The authors present a 10-year-old boy chronically treated with lisinopril, an angiotensin converting enzyme inhibitor, to control hypertension who developed hypotension following the addition of tizanidine, an alpha-2 agonist, for the treatment of spasticity."7.70Hypotension following the initiation of tizanidine in a patient treated with an angiotensin converting enzyme inhibitor for chronic hypertension. ( Johnson, TR; Tobias, JD, 2000)
"The effect of gamma-aminobutyric acid (GABA)A receptors and of the N-methyl-D-aspartate (NMDA) subtype of glutamate receptor blockade on clonidine hypotension was studied."7.69Clonidine hypotension in spontaneously hypertensive rats (SHR) depends on the functional state of GABAergic and glutamatergic systems. ( Czyzewska-Szafran, H; Goźlińska, B; Jastrzebski, Z; Mazurek, AP; Remiszewska, M, 1995)
"To test whether neostigmine would alter clonidine-induced hypotension, nine chronically prepared sheep received intrathecal injections of saline or neostigmine (150, 300, 1,000 micrograms) followed in 15 min by 200 micrograms clonidine."7.68Neostigmine counteracts spinal clonidine-induced hypotension in sheep. ( Eisenach, JC; Tong, C; Williams, JS, 1993)
"In the present study it was investigated whether hypertension induced by dopamine or hypotension induced by clonidine could influence the relative blood distribution in a s."7.68Effects of clonidine-induced hypotension and dopamine-induced hypertension on blood flows in prostatic adenocarcinoma (Dunning R3327) and normal tissues. ( Damber, JE; Grankvist, K; Henriksson, R; Jonsson, O; Widmark, A, 1992)
"Intrathecally administered clonidine produces analgesia, but also produces hypotension."7.67Epidural clonidine produces antinociception, but not hypotension, in sheep. ( Angelo, JM; Dewan, DM; Eisenach, JC; Rose, JC, 1987)
"Supplementation of the antihypertensive action of the peripheral vasodilator sodium nitroprusside (SNP) with clonidine, a centrally-acting agent, was studied in ten dogs anesthetized with isoflurane to evaluate the efficacy of clonidine for reducing the amount of SNP required during induced hypotension."7.67Effect of clonidine on sympathoadrenal response during sodium nitroprusside hypotension. ( Bloor, BC; Finander, LS; Flacke, WE; Van Etten, A, 1986)
" Clonidine testing resulted in suppression of plasma norepinephrine levels but was complicated by severe hypotension and a transient ischemic attack."7.66Symptomatic hypotension following the clonidine suppression test for pheochromocytoma. ( Dzau, VJ; Given, BD; Lilly, LS; Taylor, T, 1983)
"Hypotension was significantly more frequent in C30 group (29 versus 3% and 3% in S5 and S10 groups) (p=0,001)."6.73[30 microg intrathecal clonidine prolongs labour analgesia, but increases the incidence of hypotension and abnormal foetal heart rate patterns]. ( Belhadj Amor, M; Dhahri, S; Draief, A; Ferjani, M; Jebali, A; Lamine, K; Ouezini, R, 2007)
"Clonidine pretreatment also caused a more moderate reduction (by 45%) in the number of Fos-positive cells in the nucleus of the solitary tract, but had no effect on Fos expression in the parabrachial nucleus."5.29Clonidine and rilmenidine suppress hypotension-induced Fos expression in the lower brainstem of the conscious rabbit. ( Dampney, RA; Li, YW, 1995)
"Labetalol was administered at the conclusion of surgery as a 20-mg bolus over two minutes followed by 40 mg every 10 minutes until the desired BP was achieved (BP less than or equal to 10% above average preoperative BP or less than 150 mmHg, systolic) or 300 mg had been given."5.28Intravenous labetalol for the treatment of hypertension after carotid endarterectomy. ( Azad, SS; Goldberg, ME; Larijani, GE; Marr, AT; Seltzer, JL; Smullens, SN, 1989)
" Both the groups receiving dexmedetomidine had higher number of patients developing bradycardia as compared to patients receiving clonidine."5.22Comparision of clonidine and dexmedetomidine for attenuation of laryngoscopy and intubation response - A randomized controlled trial. ( Kakkar, A; Nabi, N; Sethi, AK; Tyagi, A; Verma, UC, 2016)
"To determine whether aspirin compared with placebo, and clonidine compared with placebo, alters the risk of perioperative acute kidney injury."5.19Perioperative aspirin and clonidine and risk of acute kidney injury: a randomized clinical trial. ( Acedillo, R; Amir, M; Bergese, S; Biccard, B; Bidgoli, SJ; Cata, JP; Cegarra, V; Chan, MT; Chan, V; Clanchet, Mde N; Cuerden, M; Devereaux, PJ; Dresser, G; Fleischmann, E; Font, A; Forget, P; Garg, AX; Gomez, MF; Jones, PM; Kumar, P; Kurz, A; Leslie, K; Malaga, G; Martinsen, K; Mehra, B; Meyhoff, CS; Mizera, R; Mrkobrada, M; Myles, P; Painter, T; Parikh, CR; Parlow, J; Pasin, L; Robinson, A; Roshanov, PS; Sessler, DI; Srinathan, S; Tiboni, M; Torres, D; VanHelder, T; Villar, JC; Walsh, M; Whitlock, R; Wijeysundera, DN; Yusuf, S, 2014)
"Administration of low-dose clonidine in patients undergoing noncardiac surgery did not reduce the rate of the composite outcome of death or nonfatal myocardial infarction; it did, however, increase the risk of clinically important hypotension and nonfatal cardiac arrest."5.19Clonidine in patients undergoing noncardiac surgery. ( Alonso-Coello, P; Amir, M; Berwanger, O; Biccard, BM; Botto, F; Chan, MT; Chow, C; Chrolavicius, S; Cook, D; Devereaux, PJ; Eikelboom, J; Fleischmann, E; Forget, P; Gao, P; Garg, AX; Graham, M; Guyatt, G; Kearon, C; Kumar, PA; Kurz, A; Lamy, A; Le Manach, Y; Leslie, K; Lurati Buse, G; Malaga, G; Meyhoff, CS; Mizera, R; Mrkobrada, M; Paniagua, P; Parlow, JL; Pasin, L; Pettit, S; Pogue, J; Robinson, A; Rodseth, RN; Sessler, DI; Sigamani, A; Srinathan, S; Tiboni, M; Torres, D; Vanhelder, T; Villar, JC; Wang, CY; Whitlock, R; Xavier, D; Yusuf, S, 2014)
" The addition of clonidine 2 microg/kg to bupivacaine provides a prolonged anesthetic action but may be associated with hypotension."5.12Clonidine 1 microg/kg is a safe and effective adjuvant to plain bupivacaine in spinal anesthesia in adolescents. ( Abdelaziz, AB; Chattaoui, O; Kaabachi, O; Kokki, H; Ouezini, R; Zarghouni, A, 2007)
"Clonidine premedication prevents tourniquet pain and reduces sympathetic nerve activity."5.11Oral clonidine premedication exacerbates hypotension following tourniquet deflation by inhibiting noradrenaline release. ( Hongo, T; Kim, C; Kobayashi, N; Maruyama, K; Ogawa, R; Takeda, S, 2004)
" The hypothesis of this study was that central NE responsivity would predict aggression response to treatment with a NE medication, pindolol."5.11Noradrenergic activity is associated with response to pindolol in aggressive Alzheimer's disease patients. ( Eryavec, G; Herrmann, N; Khan, LR; Lanctôt, KL, 2004)
"Intrathecal administration of bupivacaine and clonidine results in a significant prolongation of both motor and sensitive blocks but side effects-hypotension and bradycardia-are observed."5.08[Hemodynamic effect of intrathecal clonidine]. ( Bachour, K; Barale, F; Bettinger, G; Koeberlé, P; Rubin, L, 1995)
"The results suggest that premedication with clonidine might enhance critical hypotension during anaesthesia and surgery, but restoration both of AP and HR decrease can be achieved effectively by phenylephrine and isoproterenol i."5.08Clonidine premedication modifies responses to adrenoceptor agonists and baroreflex sensitivity. ( Dohi, S; Iida, H; Ohata, H; Tanabe, K; Watanabe, Y, 1998)
"8 years) with autistic disorder, diagnosed by DSM-III-R criteria, completed a placebo-controlled, double-blind crossover trial of clonidine."5.07Clonidine treatment of hyperactive and impulsive children with autistic disorder. ( Cook, EH; Fletcher, KE; Jaselskis, CA; Leventhal, BL, 1992)
"Alpha 2-adrenergic receptor changes during antidepressant treatment were studied using 3H-yohimbine binding to human platelet membranes and clonidine-induced hypotension."5.06Alpha 2-adrenergic receptor sensitivity in depressed patients: relation between 3H-yohimbine binding to platelet membranes and clonidine-induced hypotension. ( Gelenberg, AJ; Lydiard, RB; Wolfe, N, 1989)
" Our review, based on moderate-quality evidence, revealed that hypotension occurred frequently during the preoperative and postoperative periods, for both clonidine and dexmedetomidine."5.01Perioperative adverse events attributed to α2-adrenoceptor agonists in patients not at risk of cardiovascular events: systematic review and meta-analysis. ( Antunes, T; Demiri, M; Fletcher, D; Martinez, V, 2019)
"Clonidine poisoning usually causes depressed sensorium, hypotension, and bradycardia."4.76Clonidine overdose: report of six cases and review of the literature. ( Anderson, RJ; Crumpler, CP; Hart, GR; Lerman, MJ, 1981)
"Paediatric clonidine poisoning commonly results in bradycardia, hypotension and decreased GCS, but rarely severe or requiring major interventions."4.31Reality of clonidine poisoning in children and adolescents. ( Downes, MA; Duong, C; Isbister, GK; Lovett, C, 2023)
"The agonists of alpha(2)-adrenergic receptors such as clonidine, rilmenidine or monoxidine are known to lower blood pressure (BP) through a reduction of brain sympathetic outflow but their chronic antihypertensive effects in rats with low-renin or high-renin forms of experimental hypertension were not studied yet."4.12Blood pressure reduction induced by chronic intracerebroventricular or peroral clonidine administration in rats with salt-dependent or angiotensin II-dependent hypertension. ( Behuliak, M; Řezáčová, L; Vaněčková, I; Zicha, J, 2022)
" Some of the important safety signals included interactions between tizanidine in a suspect or interacting role and ciprofloxacin (ROR for hypotension 28."4.12A Disproportionality Analysis of Drug-Drug Interactions of Tizanidine and CYP1A2 Inhibitors from the FDA Adverse Event Reporting System (FAERS). ( Boyce, RD; Gómez-Lumbreras, A; Horn, J; Malone, DC; Tan, MS; Villa-Zapata, L, 2022)
" However, concomitant use of tizanidine with ciprofloxacin, a strong inhibitor of the P450-CYP1A2 cytochrome metabolic pathway of tizanidine, can result in increased tizanidine plasma levels and associated adverse outcomes, particularly hypotension."4.12Risk of tizanidine-induced adverse events after concomitant exposure to ciprofloxacin: A cohort study in the U.S. ( Giannouchos, TV; Gómez-Lumbreras, A; Malone, DC, 2022)
"Although administration of clonidine is often associated with bradycardia and hypotension, these complications do not seem clinically significant in a mixed PICU population with a high degree of disease severity."3.88Hemodynamic Tolerance to IV Clonidine Infusion in the PICU. ( de Wildt, SN; Kleiber, N; Tibboel, D; van Rosmalen, J, 2018)
"Administration of clonidine during hypotensive sepsis reduced renal sympathetic nerve activity, restored vascular sensitivity to both phenylephrine and angiotensin II, and resulted in better preservation of arterial pressure."3.81Clonidine Restores Pressor Responsiveness to Phenylephrine and Angiotensin II in Ovine Sepsis. ( Bellomo, R; Booth, LC; Evans, RG; Kosaka, J; Lankadeva, YR; May, CN; Quintin, L, 2015)
"Our previous studies showed that chronic ethanol feeding attenuates centrally (clonidine) evoked and potentiates peripherally (hydralazine) evoked hypotension in female rats."3.77Bradykinin B2 receptor-dependent enhancement of enalapril-evoked hypotension in ethanol-fed female rats. ( Abdel-Rahman, AA; El-Mas, MM, 2011)
" In this report, we describe a 15-year-old adolescent girl who experienced continued delirium 5 days after an overdose of quetiapine, trazodone, and clonidine."3.76Prolonged delirium after quetiapine overdose. ( Pedapati, EV; Rhyee, SH; Thompson, J, 2010)
"A case of severe bradycardia and hypotension associated with concomitant tizanidine and lisinopril therapy is reported."3.76Hypotension and bradycardia associated with concomitant tizanidine and lisinopril therapy. ( Branam, DL; Publow, SW, 2010)
"The cellular mechanisms that underlie the enhancement of clonidine-evoked hypotension in aortic barodenervated (ABD) rats and its dependence on central adenosine A(2A) receptor (A(2A)R) are not known."3.74Brainstem phosphorylated extracellular signal-regulated kinase 1/2-nitric-oxide synthase signaling mediates the adenosine A2A-dependent hypotensive action of clonidine in conscious aortic barodenervated rats. ( Abdel-Rahman, AA; Nassar, N, 2008)
"The arginine-clonidine growth hormone (GH) stimulation test causes hypotension, requiring intravenous fluids to stabilize blood pressure (BP) and delaying departure from clinic."3.74Oral hydration during growth hormone stimulation with clonidine. ( May, M; Rose, SR, 2007)
"We tested the hypothesis that clonidine-evoked hypotension is dependent on central adenosinergic pathways."3.73Central adenosine signaling plays a key role in centrally mediated hypotension in conscious aortic barodenervated rats. ( Abdel-Rahman, AA; Nassar, N, 2006)
"Clonidine (a mixed alpha2-adrenoceptor and imidazoline I1 receptor agonist)-evoked hypotension was associated with dissimilar reductions in c-jun gene expression in the rostral ventrolateral medulla (RVLM) and the nucleus tractus solitarius (NTS) in normotensive rats."3.73Site-dependent inhibition of neuronal c-jun in the brainstem elicited by imidazoline I1 receptor activation: role in rilmenidine-evoked hypotension. ( Abdel-Rahman, AA; Li, G; Wang, X, 2005)
"To identify cases of clonidine poisoning presenting to a tertiary paediatric hospital and to investigate trends in presentation, outcome and prevention."3.72Clonidine poisoning in children: a recent experience. ( Cranswick, NE; Sinha, Y, 2004)
"To report a case in which significant hypotension occurred after initiation of tizanidine in a patient using the antihypertensive agent lisinopril."3.72Hypotension due to interaction between lisinopril and tizanidine. ( Chang, JB; Chen, JT; Kao, CD; Liao, KK; Shan, DE; Wu, ZA, 2004)
"Although intrathecal clonidine produces pronounced analgesia, antinociceptive doses of intrathecal clonidine produce several side effects, including hypotension, bradycardia, and sedation."3.72Antihyperalgesic and side effects of intrathecal clonidine and tizanidine in a rat model of neuropathic pain. ( Kawamata, T; Namiki, A; Omote, K; Toriyabe, M; Wada, K; Yamamoto, H, 2003)
" The authors present a 10-year-old boy chronically treated with lisinopril, an angiotensin converting enzyme inhibitor, to control hypertension who developed hypotension following the addition of tizanidine, an alpha-2 agonist, for the treatment of spasticity."3.70Hypotension following the initiation of tizanidine in a patient treated with an angiotensin converting enzyme inhibitor for chronic hypertension. ( Johnson, TR; Tobias, JD, 2000)
"The effect of gamma-aminobutyric acid (GABA)A receptors and of the N-methyl-D-aspartate (NMDA) subtype of glutamate receptor blockade on clonidine hypotension was studied."3.69Clonidine hypotension in spontaneously hypertensive rats (SHR) depends on the functional state of GABAergic and glutamatergic systems. ( Czyzewska-Szafran, H; Goźlińska, B; Jastrzebski, Z; Mazurek, AP; Remiszewska, M, 1995)
" Selective, bilateral LC inactivation by local clonidine infusion prevented EEG activation associated with hypotension."3.68Corticotropin-releasing factor in the locus coeruleus mediates EEG activation associated with hypotensive stress. ( Berridge, CW; Foote, SL; Page, ME; Valentino, RJ, 1993)
"In this model, clonidine given prophylactically delays the toxic manifestations of bupivacaine overdose and does not accentuate the subsequent hypotension."3.68Clonidine pretreatment reduces the systemic toxicity of intravenous bupivacaine in rats. ( De Kock, M; Henin, D; Le Polain, B; Scholtes, JL; Vandewalle, F, 1993)
"To test whether neostigmine would alter clonidine-induced hypotension, nine chronically prepared sheep received intrathecal injections of saline or neostigmine (150, 300, 1,000 micrograms) followed in 15 min by 200 micrograms clonidine."3.68Neostigmine counteracts spinal clonidine-induced hypotension in sheep. ( Eisenach, JC; Tong, C; Williams, JS, 1993)
"In the present study it was investigated whether hypertension induced by dopamine or hypotension induced by clonidine could influence the relative blood distribution in a s."3.68Effects of clonidine-induced hypotension and dopamine-induced hypertension on blood flows in prostatic adenocarcinoma (Dunning R3327) and normal tissues. ( Damber, JE; Grankvist, K; Henriksson, R; Jonsson, O; Widmark, A, 1992)
"Intrathecally administered clonidine produces analgesia, but also produces hypotension."3.67Epidural clonidine produces antinociception, but not hypotension, in sheep. ( Angelo, JM; Dewan, DM; Eisenach, JC; Rose, JC, 1987)
"Intravenous injections of clonidine produce an initial transient increase in blood pressure followed by a long-lasting hypotension and bradycardia."3.67Ventrolateral medullary pressor area: site of hypotensive action of clonidine. ( Krieger, AJ; Punnen, S; Sapru, HN; Urbanski, R, 1987)
"Clonidine is a centrally acting antihypertensive agent used in the management of essential hypertension."3.67Reversal of clonidine toxicity by naloxone. ( Getzug, T; Murphy, W; Niemann, JT, 1986)
"Supplementation of the antihypertensive action of the peripheral vasodilator sodium nitroprusside (SNP) with clonidine, a centrally-acting agent, was studied in ten dogs anesthetized with isoflurane to evaluate the efficacy of clonidine for reducing the amount of SNP required during induced hypotension."3.67Effect of clonidine on sympathoadrenal response during sodium nitroprusside hypotension. ( Bloor, BC; Finander, LS; Flacke, WE; Van Etten, A, 1986)
"A patient with essential hypertension treated with clonidine developed accelerated acute clonidine withdrawal syndrome during coronary artery bypass surgery."3.66Accelerated acute clonidine withdrawal syndrome during coronary artery bypass surgery. A case report. ( O'Connor, DE, 1981)
" Clonidine testing resulted in suppression of plasma norepinephrine levels but was complicated by severe hypotension and a transient ischemic attack."3.66Symptomatic hypotension following the clonidine suppression test for pheochromocytoma. ( Dzau, VJ; Given, BD; Lilly, LS; Taylor, T, 1983)
" Ventilatory support must be available if apnea occurs."3.66Clonidine poisoning. A complex problem. ( Artman, M; Boerth, RC, 1983)
" Contrary to results obtained with clonidine, neither the fall in intraocular pressure (IOP), nor the arterial hypotension induced by delta 9-THC, were enhanced after the 'central' administration of the drug."3.66The influence of delta 9-tetrahydrocannabinol on intraocular pressure in the anaesthetized cat. ( Hermans, AJ; Innemee, HC; van Zwieten, PA, 1980)
" In contradistinction, clonidine caused a dose-related hypotension in conscious unrestrained rats subjected to sodium depletion via furosemide."3.65Hypotensive effect of clonidine during sodium depletion in the rat. ( Pals, DT, 1975)
"Hypotension was significantly more frequent in C30 group (29 versus 3% and 3% in S5 and S10 groups) (p=0,001)."2.73[30 microg intrathecal clonidine prolongs labour analgesia, but increases the incidence of hypotension and abnormal foetal heart rate patterns]. ( Belhadj Amor, M; Dhahri, S; Draief, A; Ferjani, M; Jebali, A; Lamine, K; Ouezini, R, 2007)
"As clonidine was the most effective drug in terms of preservation of pre-operative lung function, it may be clinically advantageous in post-thoracotomy patients."2.71Epidural clonidine, bupivacaine and methadone as the sole analgesic agent after thoracotomy for lung resection. ( Drenger, B; Gozal, Y; Matot, I; Shauli, A; Weissman, C, 2004)
"Significant differences in levels of withdrawal symptoms were found on days 11, 13-15 and 17-20, symptoms resolving most rapidly in the 5-day lofexidine treatment group, whilst withdrawal responses in the 10-day lofexidine treatment group were intermediate between the 5-day lofexidine and standard methadone treatment conditions."2.69Accelerated lofexidine treatment regimen compared with conventional lofexidine and methadone treatment for in-patient opiate detoxification. ( Bearn, J; Gossop, M; Strang, J, 1998)
" This study was performed to evaluate the dose-response hemodynamic and analgesic profiles of intrathecal clonidine administered after a standard surgical intervention, without perioperative administration of additional analgesics, local anesthetics, or tranquilizers."2.67Hemodynamic and analgesic profile after intrathecal clonidine in humans. A dose-response study. ( Filos, KS; Goudas, LC; Patroni, O; Polyzou, V, 1994)
"Clonidine is a central alpha adrenergic agonist which can be used to treat the opiate withdrawal syndrome."2.37Clonidine and the treatment of the opiate withdrawal syndrome. ( Gossop, M, 1988)
" Other reported effects are toxic confusional states and psychotic reactions."2.36Psychiatric side effects of antihypertensive drugs other than reserpine. ( Fleminger, R; Paykel, ES; Watson, JP, 1982)
" These compounds, when dosed of 1."1.42α-Adrenoceptor antagonistic and hypotensive properties of novel arylpiperazine derivatives of pyrrolidin-2-one. ( Bednarski, M; Dudek, M; Kulig, K; Lustyk, K; Malawska, B; Nowiński, L; Raźny, K; Sapa, J; Siwek, A; Starowicz, G; Zaręba, P, 2015)
"Clonidine was associated with the most respiratory (799, 2."1.40Unintentional pediatric exposures to central alpha-2 agonists reported to the National Poison Data System. ( Heard, K; Le Lait, MC; Wang, GS, 2014)
"During septic shock, vasopressors are a cornerstone of therapy."1.39Clonidine and dexmedetomidine increase the pressor response to norepinephrine in experimental sepsis: a pilot study. ( Chapelier, K; Cividjian, A; Dantony, E; Geloen, A; May, CN; Quintin, L; Rabilloud, M, 2013)
"We performed a prospective case series to seek dosage or clinical parameters to better identify patients who need direct medical evaluation."1.33Toxic clonidine ingestion in children. ( Anderson, DL; Colvin, JM; Johnson, PB; Klein-Schwartz, W; Spiller, HA; Villalobos, D, 2005)
"Apraclonidine eye drop is an alpha adrenergic agonist derived topical clonidine, used for the treatment of intraocular pressure elevation."1.33More than just an ocular solution. ( Karakus, G; Pekdemir, M; Yanturali, S, 2005)
"Clonidine hydrochloride is an alpha(2)-adrenergic agonist commonly prescribed as an antihypertensive agent."1.32Intentional clonidine patch ingestion by 3 adults in a detoxification unit. ( Rapko, DA; Rastegar, DA, 2003)
"To analyze the trends, demographics, and toxic effects associated with pediatric clonidine hydrochloride exposures reported to poison centers."1.31Trends and toxic effects from pediatric clonidine exposures. ( Klein-Schwartz, W, 2002)
"The hypotension was caused by decreases in cardiac index and stroke volume because peripheral resistance did not change."1.30Role of cardiac output in ethanol-evoked attenuation of centrally mediated hypotension in conscious rats. ( Abdel-Rahman, AA; El-Mas, MM, 1997)
"1."1.29Relationship between hypotensive effects and plasma concentrations of clonidine in spontaneously hypertensive rats: continuous treatment and sudden termination of clonidine infusion. ( Ishida, T; Ishii, R; Namba, K; Naruse, T; Tagawa, T, 1994)
"Clonidine pretreatment also caused a more moderate reduction (by 45%) in the number of Fos-positive cells in the nucleus of the solitary tract, but had no effect on Fos expression in the parabrachial nucleus."1.29Clonidine and rilmenidine suppress hypotension-induced Fos expression in the lower brainstem of the conscious rabbit. ( Dampney, RA; Li, YW, 1995)
"Labetalol was administered at the conclusion of surgery as a 20-mg bolus over two minutes followed by 40 mg every 10 minutes until the desired BP was achieved (BP less than or equal to 10% above average preoperative BP or less than 150 mmHg, systolic) or 300 mg had been given."1.28Intravenous labetalol for the treatment of hypertension after carotid endarterectomy. ( Azad, SS; Goldberg, ME; Larijani, GE; Marr, AT; Seltzer, JL; Smullens, SN, 1989)
" In toddlers poisoning is seen after ingestion of a single tablet of 150 micrograms clonidine, whilst in adults poisoning may occur already at a dosage just exceeding the therapeutic limit, which is subject to wide individual variation (1 to 3 tablets)."1.27[Poisoning with clonidin hydrochloride in children and adults]. ( Gössinger, H; Haubenstock, A; Hruby, K; Jung, M; Pfister, R, 1983)
"dose, a tachycardia was observed in all rats following initial transient bradycardia."1.27Tachycardic and hypertensive effects of centrally administered clonidine in conscious rats. ( Imai, Y; Johnston, CI; Nolan, PL, 1986)
"Central hypotension is induced by erythro-1-(1-[2-(1,4 - benzodioxan - 2 - yl) - 20H - ET] - 4 - piperidyl) - 2 - benzimidazolinone (R28935), as evidenced by local injections into the cisterna magna of anaesthetized dogs."1.25Centrally induced hypotension unreleated to alpha-adrenergic stimulation. ( Janssen, PA; Van Nueten, JM; Wellens, S, 1975)

Research

Studies (156)

TimeframeStudies, this research(%)All Research%
pre-199056 (35.90)18.7374
1990's33 (21.15)18.2507
2000's39 (25.00)29.6817
2010's24 (15.38)24.3611
2020's4 (2.56)2.80

Authors

AuthorsStudies
Zaręba, P1
Dudek, M1
Lustyk, K1
Siwek, A1
Starowicz, G1
Bednarski, M1
Nowiński, L1
Raźny, K1
Sapa, J1
Malawska, B1
Kulig, K1
Giannouchos, TV1
Gómez-Lumbreras, A2
Malone, DC2
Villa-Zapata, L1
Horn, J1
Tan, MS1
Boyce, RD1
Zicha, J3
Řezáčová, L3
Behuliak, M3
Vaněčková, I3
Duong, C1
Lovett, C1
Downes, MA1
Isbister, GK1
Demiri, M1
Antunes, T1
Fletcher, D1
Martinez, V1
Wang, JG1
Belley-Coté, E1
Burry, L1
Duffett, M1
Karachi, T1
Perri, D1
Alhazzani, W1
D'Aragon, F1
Wunsch, H1
Rochwerg, B1
Calzavacca, P1
Booth, LC2
Lankadeva, YR2
Bailey, SR1
Burrell, LM1
Bailey, M1
Bellomo, R2
May, CN3
Kleiber, N1
van Rosmalen, J1
Tibboel, D1
de Wildt, SN1
Chaugai, S1
Dickson, AL1
Shuey, MM1
Feng, Q1
Barker, KA1
Wei, WQ1
Luther, JM1
Stein, CM1
Chung, CP1
Geloen, A2
Chapelier, K1
Cividjian, A1
Dantony, E1
Rabilloud, M1
Quintin, L5
Wang, GS1
Le Lait, MC1
Heard, K1
Dünser, MW2
Gradwohl-Matis, I2
Vaishnava, P1
Eagle, KA1
Devereaux, PJ2
Sessler, DI2
Leslie, K2
Kurz, A2
Mrkobrada, M2
Alonso-Coello, P1
Villar, JC2
Sigamani, A1
Biccard, BM1
Meyhoff, CS2
Parlow, JL1
Guyatt, G1
Robinson, A2
Garg, AX2
Rodseth, RN1
Botto, F1
Lurati Buse, G1
Xavier, D1
Chan, MT2
Tiboni, M2
Cook, D1
Kumar, PA1
Forget, P2
Malaga, G2
Fleischmann, E2
Amir, M2
Eikelboom, J1
Mizera, R2
Torres, D2
Wang, CY1
Vanhelder, T2
Paniagua, P1
Berwanger, O1
Srinathan, S2
Graham, M1
Pasin, L2
Le Manach, Y1
Gao, P1
Pogue, J1
Whitlock, R2
Lamy, A1
Kearon, C1
Chow, C1
Pettit, S1
Chrolavicius, S1
Yusuf, S2
Geach, T1
Treschan, TA1
Kienbaum, P1
Cuerden, M1
Parikh, CR1
Jones, PM1
Font, A1
Cegarra, V1
Gomez, MF1
Parlow, J1
Clanchet, Mde N1
Bidgoli, SJ1
Martinsen, K1
Myles, P1
Acedillo, R1
Roshanov, PS1
Walsh, M1
Dresser, G1
Kumar, P1
Painter, T1
Biccard, B1
Bergese, S1
Cata, JP1
Chan, V1
Mehra, B1
Wijeysundera, DN1
Kosaka, J1
Evans, RG1
Kakkar, A1
Tyagi, A1
Nabi, N1
Sethi, AK1
Verma, UC1
Nakamura, G1
Ganem, EM1
Módolo, NS1
Rugolo, LM1
Castiglia, YM1
Publow, SW1
Branam, DL1
Rhyee, SH1
Pedapati, EV1
Thompson, J1
El-Mas, MM4
Abdel-Rahman, AA9
Pandazi, A1
Karamanis, P1
Sidiropoulou, T1
Matsota, P1
Papasideris, C1
Niokou, D1
Kostopanagiotou, G1
Apostolos, K1
Georgios, K1
Omiros, C1
Christos, T1
Blaudszun, G1
Lysakowski, C1
Elia, N1
Tramèr, MR1
Rapko, DA1
Rastegar, DA1
Halliwill, JR1
Dinenno, FA1
Dietz, NM1
Kawamata, T1
Omote, K1
Yamamoto, H1
Toriyabe, M1
Wada, K1
Namiki, A1
McGavin, CL1
John, V1
Musser, WS1
Mao, L1
Li, G3
Puskas, F1
Camporesi, EM1
O'Leary, CE1
Hauser, M1
Nasrallah, FV1
Bagheri, M1
Shekarchi, M1
Jorjani, M1
Ghahremani, MH1
Vosooghi, M1
Shafiee, A1
Zhang, Y1
Shen, KP1
Chiu, CC1
Chen, SJ1
Chen, IJ1
Wu, BN1
Maruyama, K1
Takeda, S1
Hongo, T1
Kobayashi, N1
Kim, C1
Ogawa, R1
Herrmann, N1
Lanctôt, KL1
Eryavec, G1
Khan, LR1
Matot, I1
Drenger, B1
Weissman, C1
Shauli, A1
Gozal, Y1
Kao, CD1
Chang, JB1
Chen, JT1
Wu, ZA1
Shan, DE1
Liao, KK1
Sinha, Y1
Cranswick, NE1
Spiller, HA1
Klein-Schwartz, W2
Colvin, JM1
Villalobos, D1
Johnson, PB1
Anderson, DL1
Chan, CK1
Burke, SL1
Zhu, H1
Piletz, JE1
Head, GA1
Wang, X2
Pekdemir, M1
Yanturali, S1
Karakus, G1
Marui, S1
Oliveira, CH1
Souza, SC1
Berger, K1
Khawali, C1
Hauache, OM1
Maciel, RM1
Vieira, JG1
Nassar, N2
Rachmiel, M1
Johnson, T1
Daneman, D1
Ma, RC1
Yiu, KH1
Wong, EH1
Liu, KH1
Chan, JY2
Chow, CC1
Cockram, CS1
Molderings, GJ1
Bönisch, H1
Brüss, M1
Wolf, C1
von Kügelgen, I1
Göthert, M1
Kaabachi, O1
Zarghouni, A1
Ouezini, R2
Abdelaziz, AB1
Chattaoui, O1
Kokki, H1
Hajduk, A1
Sein Anand, J1
Chodorowski, Z1
May, M1
Rose, SR1
Belhadj Amor, M1
Draief, A1
Dhahri, S1
Jebali, A1
Lamine, K1
Ferjani, M1
Momo, K1
Homma, M1
Abei, M1
Hyodo, I1
Kohda, Y1
Tsoucaris-Kupfer, D1
Bogaievsky, D1
Schmitt, H1
Hamilton, TC1
Hunt, AA1
Poyser, RH1
Timmermans, PB3
van Zwieten, PA4
Paykel, ES1
Fleminger, R1
Watson, JP1
de Jonge, A1
Bravo, EL1
Gifford, RW1
Roquebert, J1
Demichel, P1
Malek, A1
Innemee, HC1
Hermans, AJ1
Zaloga, GP1
Hostinsky, C1
Chernow, B1
Banner, W1
Lund, ME1
Clawson, L1
Given, BD1
Taylor, T1
Lilly, LS1
Dzau, VJ1
Marruecos, L1
Roglan, A1
Frati, ME1
Artigas, A1
Bousquet, P2
Feldman, J2
Schwartz, J1
Artman, M1
Boerth, RC1
Gössinger, H1
Hruby, K1
Haubenstock, A1
Jung, M1
Pfister, R1
O'Connor, DE1
Anderson, RJ1
Hart, GR1
Crumpler, CP1
Lerman, MJ1
Baum, T1
Sabin, C1
Moran, RM1
Williford, DJ1
Hamilton, BL1
Souza, JD1
Williams, TP1
DiMicco, JA1
Gillis, RA2
Li, YW1
Dampney, RA1
De Kock, M3
Versailles, H1
Colinet, B1
Karthaeuser, R1
Scholtes, JL2
Rubin, L1
Koeberlé, P1
Bachour, K1
Bettinger, G1
Barale, F1
Johnson, MA1
Blackwell, CP1
Smith, J1
Jastrzebski, Z1
Czyzewska-Szafran, H1
Goźlińska, B1
Remiszewska, M1
Mazurek, AP1
Naruse, T1
Ishida, T1
Ishii, R1
Tagawa, T1
Namba, K1
Goudas, LC2
Filos, KS2
Patroni, O1
Polyzou, V1
Page, ME1
Berridge, CW1
Foote, SL1
Valentino, RJ1
Takishita, S1
Muratani, H1
Kawazoe, N1
Kimura, Y1
Tozawa, M1
Fukiyama, K1
Le Polain, B1
Henin, D1
Vandewalle, F1
Abi-Jaoude, F1
Brusset, A1
Ceddaha, A1
Schlumberger, S1
Raffin, L1
Dubois, C1
Guilmet, D1
Fischler, M1
Williams, JS1
Tong, C1
Eisenach, JC2
Reinhart, DJ1
Wang, W1
Stagg, KS1
Walker, KG1
Bailey, PL1
Walker, EB1
Zaugg, SE1
Singelyn, FJ1
Gouverneur, JM1
Robert, A1
Dodd-o, JM1
Breslow, MJ1
Dorman, T1
Rosenfeld, BA1
Bhatara, VS1
Kallepalli, BR1
Misra, LK1
Awadallah, S1
Guyenet, PG1
Bearn, J1
Gossop, M2
Strang, J1
Ghignone, M2
Goyagi, T1
Tanaka, M1
Nishikawa, T1
Watanabe, Y1
Iida, H1
Tanabe, K1
Ohata, H1
Dohi, S1
Karnawat, BS1
Chowdhry, BR1
Medvedev, OS1
Kunduzova, OR1
Murashev, AN1
Medvedeva, NA1
Musgrave, IF1
Badoer, E1
Soares de Moura, RS1
Leão, MC1
Castro Resende, AC1
Moreira, CF1
Sena, KM1
Silveira, SS1
Lima, AF1
Nunes, FR1
Mesquita Ferreira, AG1
Tellioglu, T1
Oates, JA1
Biaggioni, I1
Johnson, TR1
Tobias, JD1
Sy, GY1
Bruban, V1
Robertson, D1
Abdulla, W1
Frey, R1
Zhang, SS1
Wang, LF1
Fu, SX1
Wellens, S1
Van Nueten, JM1
Janssen, PA1
Mofenson, HC1
Greensher, J1
Weiss, TE1
Neuvonen, PJ1
Vilska, J1
Keränen, A1
Männistö, PT1
Kokkonen, J1
Ranta, T1
Arena, G1
Tedesco, V1
Spotnitz, HM1
Mendoza, JE1
Medalie, M1
Cohen, IM1
Mottet, MM1
Francis, GS1
Alpert, JS1
Antonello, A1
Campanini, M1
Glorioso, S1
Borsatti, A1
Todesco, S1
Poyner, TF1
Gennery, BA1
Vasey, RH1
Pals, DT1
Gulati, A1
Jaselskis, CA1
Cook, EH1
Fletcher, KE1
Leventhal, BL1
Jonsson, O1
Widmark, A1
Grankvist, K1
Damber, JE1
Henriksson, R1
Johnson, VG1
Romanoff, ME1
Flacke, JW1
Garty, M1
Deka-Starosta, A1
Chang, P1
Kopin, IJ1
Goldstein, DS1
Wright, PM1
Carabine, UA1
McClune, S1
Orr, DA1
Moore, J1
Böhrer, H1
Bach, A1
Layer, M1
Werning, P1
Wolfe, N1
Gelenberg, AJ1
Lydiard, RB1
Goldberg, ME1
Seltzer, JL1
Azad, SS1
Smullens, SN1
Marr, AT1
Larijani, GE1
Durá Trave, T1
Moya Benavent, M1
Buades Esplá, A1
Fruncillo, RJ1
Gibbons, WJ1
Vlasses, PH1
Ferguson, RK1
Gatti, PJ1
Hill, KJ1
Da Silva, AM1
Norman, WP1
Filatov, AV1
Bentley, GA1
Caravati, EM1
Bennett, DL1
Weigel, JJ1
Schlund, J1
Derlet, RW1
Dewan, DM1
Rose, JC1
Angelo, JM1
Gillon, JY1
Pujol, JF1
Punnen, S1
Urbanski, R1
Krieger, AJ1
Sapru, HN1
Imai, Y1
Nolan, PL1
Johnston, CI1
Niemann, JT1
Getzug, T1
Murphy, W1
Bloor, BC1
Finander, LS1
Flacke, WE1
Van Etten, A1
Deutsch, J1
Grubbauer, HM1
Beitzke, A1
Chan, SH1
Massarano, AA1
Bauer, GE1
Bolme, P1
Fuxe, K1
Lidbrink, P1
Conrads, H1
Sayegh, F1
Hartmann, J1
Weigelin, E1

Clinical Trials (11)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Dexmedetomidine Improve Microcirculatory Alterations in Initial Resuscitated Septic Shock Patients[NCT02270281]Phase 444 participants (Actual)Interventional2014-12-31Completed
Low-Dose Dexmedetomidine for Delirium Prevention in Mechanically Ventilated Septic Patients in Intensive Care Unit: a Multi-Center, Randomized, Double-Blind, Placebo-Controlled Trial[NCT04876937]116 participants (Anticipated)Interventional2021-05-28Recruiting
A Large, International, Placebo-controlled, Factorial Trial to Assess the Impact of Clonidine and Acetyl-salicylic Acid (ASA) in Patients Undergoing Noncardiac Surgery Who Are at Risk of a Perioperative Cardiovascular Event[NCT01082874]Phase 310,010 participants (Actual)Interventional2010-07-31Completed
Effect of Target Intraoperative Blood Pressure on the Incidence of Post-operative Cognitive Dysfunction in Patients Aged 75 and Older Undergoing General Anesthesia for Non-cardiac Surgery: an International Multicenter Randomized Controlled Trial[NCT02428062]Phase 2/Phase 31,812 participants (Anticipated)Interventional2014-10-31Suspended (stopped due to Pending Pilot study results evaluation)
Labor Analgesia With Ropivacaine Added to Clonidine. A Randomized Clinical Trial[NCT00626977]32 participants (Actual)Observational2000-05-31Completed
A Prospective Study Comparing Total Intravenous Anesthesia With Propofol and Remifentanil vs. Propofol and Dexmedetomidine in Adolescent Idiopathic Scoliosis Patients Undergoing Posterior Spinal Fusion and Instrumentation[NCT06096181]Phase 2120 participants (Anticipated)Interventional2023-12-31Not yet recruiting
Intravenous Lidocaine and Time to Regression of the Sensory Block After Spinal Anesthesia With Isobaric Bupivacaine in Patients Undergoing Surgery to Treat Skin and Soft Tissue Tumors of the Lower Limbs[NCT04741880]Phase 2/Phase 366 participants (Anticipated)Interventional2021-06-17Recruiting
Guanfacine for PONV and Pain After Sinus Surgery[NCT02882854]84 participants (Actual)Interventional2016-11-30Completed
A Comparison of Morphine and Morphine Plus Dexmedetomidine in Chronic Cancer Pain[NCT02289261]Phase 440 participants (Actual)Interventional2014-11-30Completed
Phase I-II Clinical Trial to Determine the Safety of Clonidine in Infants With Hypoxic Ischemic Encephalopathy During Therapeutic Hypothermia[NCT01862250]Phase 1/Phase 213 participants (Actual)Interventional2013-10-03Completed
Effect of Clonidine vs. Dexmedetomidine in Addition to Standard Treatment in Agitated Delirium in Intensive Care Patients: Pilot Study.[NCT04758936]Phase 450 participants (Anticipated)Interventional2021-02-01Recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Composite of All-cause Mortality and Nonfatal MI

(NCT01082874)
Timeframe: 30 days

Interventionparticipants (Number)
Active Clonidine and Active ASA173
Active Clonidine and Placebo ASA194
Placebo Clonidine and Active ASA178
Placebo Clonidine and Placebo ASA161

PACU Length of Stay in Minutes

(NCT02882854)
Timeframe: Time frame between arrival and discharge in PACU, approximately 90 minutes

Interventionminutes (Median)
Guanfacine128
Placebo110

Postoperative Nausea Assessment Using 11-point Nausea Scale (nVRS)

PONV assessed using nVRS at 24 hours postop when 0 is no nausea and 10 is worst nausea. (NCT02882854)
Timeframe: 24 hours post op

Interventionscore on a scale (Median)
Guanfacine0.00
Placebo0.00

Postoperative Pain Assessment Using 11-point Visual/Verbal Analog (VAS)

Postoperative pain assessment using VAS at 24 hours postop when 0 is no pain and 10 is worst pain (NCT02882854)
Timeframe: 24 hours postop

Interventionscore on a scale (Median)
Guanfacine3
Placebo2

Total Narcotic Requirement in PACU

Total narcotic requirement in PACU tallied in morphine equivalents during PACU stay (NCT02882854)
Timeframe: Time frame between arrival and discharge in PACU, approximately 90 minutes

Interventionmorphine equivalents (Median)
Guanfacine8.75
Placebo7.50

Maximum Postoperative Pain Assessment Using 11-point Visual/Verbal Analog (VAS)

Maximum postoperative pain assessment assessed in PACU at 15, 30 and 60 minutes after PACU arrival using VAS when 0 is no pain and 10 is worst pain (NCT02882854)
Timeframe: 15, 30, 60 minutes after arriving in PACU

InterventionParticipants (Count of Participants)
15 minutes after PACU admission7248297715 minutes after PACU admission7248297830 minutes after PACU admission7248297730 minutes after PACU admission7248297860 minutes after PACU admission7248297760 minutes after PACU admission72482978
Mild (Pain nVRS 1-5)Moderate/Severe (Pain nVRS 6-10)None (Pain nVRS 0)
Guanfacine31
Placebo24
Guanfacine0
Placebo5
Guanfacine8
Placebo10
Guanfacine18
Placebo20
Guanfacine7
Placebo6
Guanfacine14
Placebo14
Guanfacine12
Placebo16
Guanfacine6
Placebo13
Guanfacine21
Placebo12

Amount of Morphine Given

Intravenous morphine (mg/kg) was given. The standard dose is 0.05 mg/kg per dose (NCT01862250)
Timeframe: Up to 2 days

Interventionmg/kg (Median)
Clonidine Infants With HIE0.02

Presence of Shivering After Clonidine

Babies were assessed after administration of clonidine for the presence or absence of shivering. (NCT01862250)
Timeframe: 48hrs

InterventionParticipants (Count of Participants)
Clonidine Infants With HIE0

Steady State Clonidine Blood Levels During Hypothermia

"Trough clonidine blood levels were measured after 4-7 doses of clonidine were given intravenously with a dosing interval of every 8 hrs. Mean and standard deviation (SD) of the number of doses given prior to levels being drawn was 5.3 (mean) and 0.37 (SD).~Time after last dose before measurement was 9hrs (mean) and 2.7hrs (SD)." (NCT01862250)
Timeframe: 3 days

Interventionng/ml (Median)
Clonidine Infants With HIE0.6

Time to Passive Rewarming

Following 2 hours of therapeutic hypothermia, the temperature of the thermo-blanket is adjusted up half degree per hour allowing passive rewarming until 36.5 degrees is reached (NCT01862250)
Timeframe: Beginning at 72 hours up to 12 hours

InterventionHours (Median)
Clonidine Infants With HIE8.7

Reviews

12 reviews available for clonidine and Hypotension

ArticleYear
Perioperative adverse events attributed to α2-adrenoceptor agonists in patients not at risk of cardiovascular events: systematic review and meta-analysis.
    British journal of anaesthesia, 2019, Volume: 123, Issue:6

    Topics: Adrenergic alpha-2 Receptor Agonists; Bradycardia; Clonidine; Dexmedetomidine; Humans; Hypotension;

2019
Clonidine for sedation in the critically ill: a systematic review and meta-analysis.
    Critical care (London, England), 2017, Feb-25, Volume: 21, Issue:1

    Topics: Clonidine; Critical Illness; Humans; Hypnotics and Sedatives; Hypotension; Intensive Care Units; Len

2017
Effect of perioperative systemic α2 agonists on postoperative morphine consumption and pain intensity: systematic review and meta-analysis of randomized controlled trials.
    Anesthesiology, 2012, Volume: 116, Issue:6

    Topics: Adrenergic alpha-2 Receptor Agonists; Analgesics, Opioid; Anesthesia Recovery Period; Clonidine; Dex

2012
Effect of perioperative systemic α2 agonists on postoperative morphine consumption and pain intensity: systematic review and meta-analysis of randomized controlled trials.
    Anesthesiology, 2012, Volume: 116, Issue:6

    Topics: Adrenergic alpha-2 Receptor Agonists; Analgesics, Opioid; Anesthesia Recovery Period; Clonidine; Dex

2012
Effect of perioperative systemic α2 agonists on postoperative morphine consumption and pain intensity: systematic review and meta-analysis of randomized controlled trials.
    Anesthesiology, 2012, Volume: 116, Issue:6

    Topics: Adrenergic alpha-2 Receptor Agonists; Analgesics, Opioid; Anesthesia Recovery Period; Clonidine; Dex

2012
Effect of perioperative systemic α2 agonists on postoperative morphine consumption and pain intensity: systematic review and meta-analysis of randomized controlled trials.
    Anesthesiology, 2012, Volume: 116, Issue:6

    Topics: Adrenergic alpha-2 Receptor Agonists; Analgesics, Opioid; Anesthesia Recovery Period; Clonidine; Dex

2012
Effect of perioperative systemic α2 agonists on postoperative morphine consumption and pain intensity: systematic review and meta-analysis of randomized controlled trials.
    Anesthesiology, 2012, Volume: 116, Issue:6

    Topics: Adrenergic alpha-2 Receptor Agonists; Analgesics, Opioid; Anesthesia Recovery Period; Clonidine; Dex

2012
Effect of perioperative systemic α2 agonists on postoperative morphine consumption and pain intensity: systematic review and meta-analysis of randomized controlled trials.
    Anesthesiology, 2012, Volume: 116, Issue:6

    Topics: Adrenergic alpha-2 Receptor Agonists; Analgesics, Opioid; Anesthesia Recovery Period; Clonidine; Dex

2012
Effect of perioperative systemic α2 agonists on postoperative morphine consumption and pain intensity: systematic review and meta-analysis of randomized controlled trials.
    Anesthesiology, 2012, Volume: 116, Issue:6

    Topics: Adrenergic alpha-2 Receptor Agonists; Analgesics, Opioid; Anesthesia Recovery Period; Clonidine; Dex

2012
Effect of perioperative systemic α2 agonists on postoperative morphine consumption and pain intensity: systematic review and meta-analysis of randomized controlled trials.
    Anesthesiology, 2012, Volume: 116, Issue:6

    Topics: Adrenergic alpha-2 Receptor Agonists; Analgesics, Opioid; Anesthesia Recovery Period; Clonidine; Dex

2012
Effect of perioperative systemic α2 agonists on postoperative morphine consumption and pain intensity: systematic review and meta-analysis of randomized controlled trials.
    Anesthesiology, 2012, Volume: 116, Issue:6

    Topics: Adrenergic alpha-2 Receptor Agonists; Analgesics, Opioid; Anesthesia Recovery Period; Clonidine; Dex

2012
Effect of perioperative systemic α2 agonists on postoperative morphine consumption and pain intensity: systematic review and meta-analysis of randomized controlled trials.
    Anesthesiology, 2012, Volume: 116, Issue:6

    Topics: Adrenergic alpha-2 Receptor Agonists; Analgesics, Opioid; Anesthesia Recovery Period; Clonidine; Dex

2012
Effect of perioperative systemic α2 agonists on postoperative morphine consumption and pain intensity: systematic review and meta-analysis of randomized controlled trials.
    Anesthesiology, 2012, Volume: 116, Issue:6

    Topics: Adrenergic alpha-2 Receptor Agonists; Analgesics, Opioid; Anesthesia Recovery Period; Clonidine; Dex

2012
Effect of perioperative systemic α2 agonists on postoperative morphine consumption and pain intensity: systematic review and meta-analysis of randomized controlled trials.
    Anesthesiology, 2012, Volume: 116, Issue:6

    Topics: Adrenergic alpha-2 Receptor Agonists; Analgesics, Opioid; Anesthesia Recovery Period; Clonidine; Dex

2012
Effect of perioperative systemic α2 agonists on postoperative morphine consumption and pain intensity: systematic review and meta-analysis of randomized controlled trials.
    Anesthesiology, 2012, Volume: 116, Issue:6

    Topics: Adrenergic alpha-2 Receptor Agonists; Analgesics, Opioid; Anesthesia Recovery Period; Clonidine; Dex

2012
Effect of perioperative systemic α2 agonists on postoperative morphine consumption and pain intensity: systematic review and meta-analysis of randomized controlled trials.
    Anesthesiology, 2012, Volume: 116, Issue:6

    Topics: Adrenergic alpha-2 Receptor Agonists; Analgesics, Opioid; Anesthesia Recovery Period; Clonidine; Dex

2012
Effect of perioperative systemic α2 agonists on postoperative morphine consumption and pain intensity: systematic review and meta-analysis of randomized controlled trials.
    Anesthesiology, 2012, Volume: 116, Issue:6

    Topics: Adrenergic alpha-2 Receptor Agonists; Analgesics, Opioid; Anesthesia Recovery Period; Clonidine; Dex

2012
Effect of perioperative systemic α2 agonists on postoperative morphine consumption and pain intensity: systematic review and meta-analysis of randomized controlled trials.
    Anesthesiology, 2012, Volume: 116, Issue:6

    Topics: Adrenergic alpha-2 Receptor Agonists; Analgesics, Opioid; Anesthesia Recovery Period; Clonidine; Dex

2012
Psychiatric side effects of antihypertensive drugs other than reserpine.
    Journal of clinical psychopharmacology, 1982, Volume: 2, Issue:1

    Topics: Adrenergic beta-Antagonists; Antihypertensive Agents; Anxiety; Bethanidine; Clonidine; Debrisoquin;

1982
Current concepts. Pheochromocytoma: diagnosis, localization and management.
    The New England journal of medicine, 1984, Nov-15, Volume: 311, Issue:20

    Topics: Adrenal Gland Neoplasms; Adrenergic beta-Antagonists; Blood Pressure; Catecholamines; Clonidine; Glu

1984
Endogenous opioid peptides: critical care implications.
    Heart & lung : the journal of critical care, 1984, Volume: 13, Issue:4

    Topics: Animals; Body Temperature Regulation; Cardiovascular System; Clonidine; Endorphins; Halothane; Human

1984
Clonidine overdose: report of six cases and review of the literature.
    Annals of emergency medicine, 1981, Volume: 10, Issue:2

    Topics: Adolescent; Adult; Atropine; Bradycardia; Child, Preschool; Clonidine; Dopamine; Female; Humans; Hyp

1981
Is the hypotensive effect of clonidine and related drugs due to imidazoline binding sites?
    The American journal of physiology, 1997, Volume: 273, Issue:5

    Topics: Adrenergic alpha-Agonists; Animals; Antihypertensive Agents; Binding Sites; Blood Pressure; Clonidin

1997
Diagnosis and management of baroreflex failure.
    Primary cardiology, 1995, Volume: 21, Issue:1

    Topics: Antihypertensive Agents; Autonomic Nervous System Diseases; Baroreflex; Bradycardia; Carotid Sinus;

1995
Clonidine and the treatment of the opiate withdrawal syndrome.
    Drug and alcohol dependence, 1988, Volume: 21, Issue:3

    Topics: Clonidine; Humans; Hypotension; Methadone; Naltrexone; Narcotics; Substance Withdrawal Syndrome

1988
Clonidine, a widow's cruse for pharmacologists.
    Clinical and experimental pharmacology & physiology, 1987, Volume: 14, Issue:5

    Topics: Animals; Blood Pressure; Cats; Clonidine; Hypotension; In Vitro Techniques

1987
On the function of central catecholamine neurons--their role in cardiovascular and arousal mechanisms.
    Research communications in chemical pathology and pharmacology, 1972, Volume: 4, Issue:3

    Topics: Adrenergic alpha-Antagonists; Animals; Bradycardia; Brain; Cardiovascular Physiological Phenomena; C

1972

Trials

24 trials available for clonidine and Hypotension

ArticleYear
Clonidine in patients undergoing noncardiac surgery.
    The New England journal of medicine, 2014, Apr-17, Volume: 370, Issue:16

    Topics: Adrenergic alpha-2 Receptor Agonists; Aged; Clonidine; Female; Humans; Hypotension; Kaplan-Meier Est

2014
Clonidine in patients undergoing noncardiac surgery.
    The New England journal of medicine, 2014, Apr-17, Volume: 370, Issue:16

    Topics: Adrenergic alpha-2 Receptor Agonists; Aged; Clonidine; Female; Humans; Hypotension; Kaplan-Meier Est

2014
Clonidine in patients undergoing noncardiac surgery.
    The New England journal of medicine, 2014, Apr-17, Volume: 370, Issue:16

    Topics: Adrenergic alpha-2 Receptor Agonists; Aged; Clonidine; Female; Humans; Hypotension; Kaplan-Meier Est

2014
Clonidine in patients undergoing noncardiac surgery.
    The New England journal of medicine, 2014, Apr-17, Volume: 370, Issue:16

    Topics: Adrenergic alpha-2 Receptor Agonists; Aged; Clonidine; Female; Humans; Hypotension; Kaplan-Meier Est

2014
Perioperative aspirin and clonidine and risk of acute kidney injury: a randomized clinical trial.
    JAMA, 2014, Dec-03, Volume: 312, Issue:21

    Topics: Acute Kidney Injury; Administration, Cutaneous; Administration, Oral; Adrenergic alpha-2 Receptor Ag

2014
Comparision of clonidine and dexmedetomidine for attenuation of laryngoscopy and intubation response - A randomized controlled trial.
    Journal of clinical anesthesia, 2016, Volume: 33

    Topics: Adolescent; Adrenergic alpha-2 Receptor Agonists; Adult; Anesthesia, General; Blood Pressure; Bradyc

2016
Labor analgesia with ropivacaine added to clonidine: a randomized clinical trial.
    Sao Paulo medical journal = Revista paulista de medicina, 2008, Mar-06, Volume: 126, Issue:2

    Topics: Adult; Amides; Analgesia, Epidural; Analgesia, Obstetrical; Analgesics; Anesthetics, Local; Apgar Sc

2008
Low-dose (1 microg/kg) clonidine premedication and hypotension after carotid artery surgery.
    Vascular and endovascular surgery, 2011, Volume: 45, Issue:7

    Topics: Adrenergic alpha-2 Receptor Agonists; Aged; Analysis of Variance; Antihypertensive Agents; Blood Pre

2011
Comparison between ropivacaine 1.5 mg ml(-1) plus fentanyl 2 mg ml(-1) and ropivacaine 1.5 mg ml(-1) plus clonidine 1 mg ml(-1) as analgesic solution after anterior cruciate ligament reconstruction: a randomized clinical trial.
    Middle East journal of anaesthesiology, 2011, Volume: 21, Issue:3

    Topics: Adrenergic alpha-Agonists; Adult; Amides; Anesthetics, Intravenous; Anesthetics, Local; Anterior Cru

2011
Oral clonidine premedication exacerbates hypotension following tourniquet deflation by inhibiting noradrenaline release.
    Journal of Nippon Medical School = Nippon Ika Daigaku zasshi, 2004, Volume: 71, Issue:1

    Topics: Administration, Oral; Adrenergic alpha-Agonists; Adult; Anesthesia, Spinal; Blood Pressure; Clonidin

2004
Noradrenergic activity is associated with response to pindolol in aggressive Alzheimer's disease patients.
    Journal of psychopharmacology (Oxford, England), 2004, Volume: 18, Issue:2

    Topics: Administration, Oral; Aged; Aged, 80 and over; Aggression; Alzheimer Disease; Behavioral Symptoms; C

2004
Epidural clonidine, bupivacaine and methadone as the sole analgesic agent after thoracotomy for lung resection.
    Anaesthesia, 2004, Volume: 59, Issue:9

    Topics: Adult; Aged; Analgesia, Epidural; Analgesics; Bupivacaine; Clonidine; Double-Blind Method; Female; H

2004
Clonidine 1 microg/kg is a safe and effective adjuvant to plain bupivacaine in spinal anesthesia in adolescents.
    Anesthesia and analgesia, 2007, Volume: 105, Issue:2

    Topics: Adjuvants, Pharmaceutic; Adolescent; Anesthesia, Spinal; Bupivacaine; Child; Clonidine; Double-Blind

2007
[30 microg intrathecal clonidine prolongs labour analgesia, but increases the incidence of hypotension and abnormal foetal heart rate patterns].
    Annales francaises d'anesthesie et de reanimation, 2007, Volume: 26, Issue:11

    Topics: Analgesics; Anesthesia, Spinal; Bupivacaine; Clonidine; Dose-Response Relationship, Drug; Female; He

2007
Epidemiology of the adverse hemodynamic events occurring during "clonidine anesthesia": a prospective open trial of intraoperative intravenous clonidine.
    Journal of clinical anesthesia, 1995, Volume: 7, Issue:5

    Topics: Abdomen; Adrenergic alpha-Agonists; Anesthesia, Inhalation; Anesthesia, Intravenous; Anesthetics, In

1995
[Hemodynamic effect of intrathecal clonidine].
    Cahiers d'anesthesiologie, 1995, Volume: 43, Issue:3

    Topics: Aged; Analgesics, Opioid; Anesthesia, Spinal; Anesthetics, Local; Blood Pressure; Bupivacaine; Cloni

1995
Antagonism of the effects of clonidine by the alpha 2-adrenoceptor antagonist, fluparoxan.
    British journal of clinical pharmacology, 1995, Volume: 39, Issue:5

    Topics: Administration, Oral; Adrenergic alpha-Antagonists; Adult; Antidepressive Agents; Blood Pressure; Br

1995
Hemodynamic and analgesic profile after intrathecal clonidine in humans. A dose-response study.
    Anesthesiology, 1994, Volume: 81, Issue:3

    Topics: Adult; Analgesia, Obstetrical; Blood Pressure; Cesarean Section; Clonidine; Conscious Sedation; Dose

1994
Clonidine premedication for coronary artery bypass grafting under high-dose alfentanil anesthesia: intraoperative and postoperative hemodynamic study.
    Journal of cardiothoracic and vascular anesthesia, 1993, Volume: 7, Issue:1

    Topics: Alfentanil; Anesthesia, Intravenous; Blood Pressure; Cardiac Output; Clonidine; Coronary Artery Bypa

1993
Postoperative analgesia after peripheral nerve block for podiatric surgery: clinical efficacy and chemical stability of lidocaine alone versus lidocaine plus clonidine.
    Anesthesia and analgesia, 1996, Volume: 83, Issue:4

    Topics: Adrenergic alpha-Agonists; Adult; Analgesia; Analgesics; Analysis of Variance; Anesthetics, Local; A

1996
A minimum dose of clonidine added to mepivacaine prolongs the duration of anesthesia and analgesia after axillary brachial plexus block.
    Anesthesia and analgesia, 1996, Volume: 83, Issue:5

    Topics: Adrenergic alpha-Agonists; Adult; Ambulatory Surgical Procedures; Analgesia; Analgesics; Anesthetics

1996
Accelerated lofexidine treatment regimen compared with conventional lofexidine and methadone treatment for in-patient opiate detoxification.
    Drug and alcohol dependence, 1998, May-01, Volume: 50, Issue:3

    Topics: Adult; Analysis of Variance; Chi-Square Distribution; Clonidine; Dose-Response Relationship, Drug; D

1998
Oral clonidine premedication enhances the pressor response to ephedrine during spinal anesthesia.
    Anesthesia and analgesia, 1998, Volume: 87, Issue:6

    Topics: Administration, Oral; Adult; Anesthesia, Spinal; Blood Pressure; Clonidine; Drug Synergism; Ephedrin

1998
Clonidine premedication modifies responses to adrenoceptor agonists and baroreflex sensitivity.
    Canadian journal of anaesthesia = Journal canadien d'anesthesie, 1998, Volume: 45, Issue:11

    Topics: Adrenergic alpha-Agonists; Adrenergic beta-Agonists; Adult; Anesthesia, General; Baroreflex; Blood P

1998
Clonidine treatment of hyperactive and impulsive children with autistic disorder.
    Journal of clinical psychopharmacology, 1992, Volume: 12, Issue:5

    Topics: Ambulatory Care; Attention Deficit Disorder with Hyperactivity; Attitude to Health; Autistic Disorde

1992
Preanaesthetic medication with clonidine.
    British journal of anaesthesia, 1990, Volume: 65, Issue:5

    Topics: Administration, Oral; Adult; Anxiety; Clonidine; Double-Blind Method; Female; Heart Rate; Humans; Hy

1990
Alpha 2-adrenergic receptor sensitivity in depressed patients: relation between 3H-yohimbine binding to platelet membranes and clonidine-induced hypotension.
    Biological psychiatry, 1989, Feb-15, Volume: 25, Issue:4

    Topics: Adult; Blood Platelets; Blood Pressure; Cell Membrane; Clinical Trials as Topic; Clonidine; Depressi

1989

Other Studies

120 other studies available for clonidine and Hypotension

ArticleYear
α-Adrenoceptor antagonistic and hypotensive properties of novel arylpiperazine derivatives of pyrrolidin-2-one.
    Bioorganic & medicinal chemistry, 2015, May-01, Volume: 23, Issue:9

    Topics: Adrenergic alpha-1 Receptor Antagonists; Animals; Dose-Response Relationship, Drug; Hypotension; Mal

2015
Risk of tizanidine-induced adverse events after concomitant exposure to ciprofloxacin: A cohort study in the U.S.
    The American journal of emergency medicine, 2022, Volume: 55

    Topics: Ciprofloxacin; Clonidine; Cohort Studies; Drug Interactions; Female; Humans; Hypotension; Middle Age

2022
A Disproportionality Analysis of Drug-Drug Interactions of Tizanidine and CYP1A2 Inhibitors from the FDA Adverse Event Reporting System (FAERS).
    Drug safety, 2022, Volume: 45, Issue:8

    Topics: Adverse Drug Reaction Reporting Systems; Ciprofloxacin; Clonidine; Cytochrome P-450 CYP1A2; Cytochro

2022
Blood pressure reduction induced by chronic intracerebroventricular or peroral clonidine administration in rats with salt-dependent or angiotensin II-dependent hypertension.
    Physiological research, 2022, Dec-16, Volume: 71, Issue:6

    Topics: Angiotensin II; Animals; Antihypertensive Agents; Blood Pressure; Clonidine; Hypertension; Hypotensi

2022
Blood pressure reduction induced by chronic intracerebroventricular or peroral clonidine administration in rats with salt-dependent or angiotensin II-dependent hypertension.
    Physiological research, 2022, Dec-16, Volume: 71, Issue:6

    Topics: Angiotensin II; Animals; Antihypertensive Agents; Blood Pressure; Clonidine; Hypertension; Hypotensi

2022
Blood pressure reduction induced by chronic intracerebroventricular or peroral clonidine administration in rats with salt-dependent or angiotensin II-dependent hypertension.
    Physiological research, 2022, Dec-16, Volume: 71, Issue:6

    Topics: Angiotensin II; Animals; Antihypertensive Agents; Blood Pressure; Clonidine; Hypertension; Hypotensi

2022
Blood pressure reduction induced by chronic intracerebroventricular or peroral clonidine administration in rats with salt-dependent or angiotensin II-dependent hypertension.
    Physiological research, 2022, Dec-16, Volume: 71, Issue:6

    Topics: Angiotensin II; Animals; Antihypertensive Agents; Blood Pressure; Clonidine; Hypertension; Hypotensi

2022
Blood pressure reduction induced by chronic intracerebroventricular or peroral clonidine administration in rats with salt-dependent or angiotensin II-dependent hypertension.
    Physiological research, 2022, Dec-16, Volume: 71, Issue:6

    Topics: Angiotensin II; Animals; Antihypertensive Agents; Blood Pressure; Clonidine; Hypertension; Hypotensi

2022
Blood pressure reduction induced by chronic intracerebroventricular or peroral clonidine administration in rats with salt-dependent or angiotensin II-dependent hypertension.
    Physiological research, 2022, Dec-16, Volume: 71, Issue:6

    Topics: Angiotensin II; Animals; Antihypertensive Agents; Blood Pressure; Clonidine; Hypertension; Hypotensi

2022
Blood pressure reduction induced by chronic intracerebroventricular or peroral clonidine administration in rats with salt-dependent or angiotensin II-dependent hypertension.
    Physiological research, 2022, Dec-16, Volume: 71, Issue:6

    Topics: Angiotensin II; Animals; Antihypertensive Agents; Blood Pressure; Clonidine; Hypertension; Hypotensi

2022
Blood pressure reduction induced by chronic intracerebroventricular or peroral clonidine administration in rats with salt-dependent or angiotensin II-dependent hypertension.
    Physiological research, 2022, Dec-16, Volume: 71, Issue:6

    Topics: Angiotensin II; Animals; Antihypertensive Agents; Blood Pressure; Clonidine; Hypertension; Hypotensi

2022
Blood pressure reduction induced by chronic intracerebroventricular or peroral clonidine administration in rats with salt-dependent or angiotensin II-dependent hypertension.
    Physiological research, 2022, Dec-16, Volume: 71, Issue:6

    Topics: Angiotensin II; Animals; Antihypertensive Agents; Blood Pressure; Clonidine; Hypertension; Hypotensi

2022
Reality of clonidine poisoning in children and adolescents.
    Journal of paediatrics and child health, 2023, Volume: 59, Issue:6

    Topics: Adolescent; Atropine; Bradycardia; Child; Child, Preschool; Clonidine; Female; Humans; Hypotension;

2023
Effects of Clonidine on the Cardiovascular, Renal, and Inflammatory Responses to Experimental Bacteremia.
    Shock (Augusta, Ga.), 2019, Volume: 51, Issue:3

    Topics: Acute Kidney Injury; Animals; Arginine Vasopressin; Bacteremia; Cardiac Output; Clonidine; Disease M

2019
Hemodynamic Tolerance to IV Clonidine Infusion in the PICU.
    Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies, 2018, Volume: 19, Issue:8

    Topics: Administration, Intravenous; Blood Pressure; Body Temperature; Bradycardia; Child, Preschool; Clonid

2018
Co-Prescription of Strong CYP1A2 Inhibitors and the Risk of Tizanidine-Associated Hypotension: A Retrospective Cohort Study.
    Clinical pharmacology and therapeutics, 2019, Volume: 105, Issue:3

    Topics: Adult; Clonidine; Cohort Studies; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP1A2 Inhibitors; Drug

2019
Clonidine and dexmedetomidine increase the pressor response to norepinephrine in experimental sepsis: a pilot study.
    Critical care medicine, 2013, Volume: 41, Issue:12

    Topics: Adrenergic alpha-2 Receptor Agonists; Animals; Arterial Pressure; Clonidine; Dexmedetomidine; Hypote

2013
Clonidine and dexmedetomidine increase the pressor response to norepinephrine in experimental sepsis: a pilot study.
    Critical care medicine, 2013, Volume: 41, Issue:12

    Topics: Adrenergic alpha-2 Receptor Agonists; Animals; Arterial Pressure; Clonidine; Dexmedetomidine; Hypote

2013
Clonidine and dexmedetomidine increase the pressor response to norepinephrine in experimental sepsis: a pilot study.
    Critical care medicine, 2013, Volume: 41, Issue:12

    Topics: Adrenergic alpha-2 Receptor Agonists; Animals; Arterial Pressure; Clonidine; Dexmedetomidine; Hypote

2013
Clonidine and dexmedetomidine increase the pressor response to norepinephrine in experimental sepsis: a pilot study.
    Critical care medicine, 2013, Volume: 41, Issue:12

    Topics: Adrenergic alpha-2 Receptor Agonists; Animals; Arterial Pressure; Clonidine; Dexmedetomidine; Hypote

2013
Unintentional pediatric exposures to central alpha-2 agonists reported to the National Poison Data System.
    The Journal of pediatrics, 2014, Volume: 164, Issue:1

    Topics: Adrenergic alpha-2 Receptor Agonists; Bradycardia; Child; Child, Preschool; Clonidine; Female; Guanf

2014
α(2)-agonists to restore adrenergic vasoconstrictor responsiveness in septic shock: thinking outside of the box or fishing in the wrong pond?
    Critical care medicine, 2013, Volume: 41, Issue:12

    Topics: Adrenergic alpha-2 Receptor Agonists; Animals; Arterial Pressure; Clonidine; Dexmedetomidine; Hypote

2013
The yin and yang of perioperative medicine.
    The New England journal of medicine, 2014, Apr-17, Volume: 370, Issue:16

    Topics: Adrenergic alpha-2 Receptor Agonists; Aspirin; Clonidine; Female; Humans; Hypotension; Male; Myocard

2014
Surgery: Low-dose aspirin and clonidine--no benefit during surgery.
    Nature reviews. Cardiology, 2014, Volume: 11, Issue:6

    Topics: Adrenergic alpha-2 Receptor Agonists; Aspirin; Clonidine; Female; Humans; Hypotension; Male; Myocard

2014
[Comments on: perioperative administration of clonidine or aspirin].
    Der Anaesthesist, 2014, Volume: 63, Issue:6

    Topics: Adrenergic alpha-2 Receptor Agonists; Aspirin; Clonidine; Female; Humans; Hypotension; Male; Myocard

2014
Clonidine Restores Pressor Responsiveness to Phenylephrine and Angiotensin II in Ovine Sepsis.
    Critical care medicine, 2015, Volume: 43, Issue:7

    Topics: Adrenergic alpha-2 Receptor Agonists; Angiotensin II; Animals; Blood Pressure; Clonidine; Female; Hy

2015
Reverse Physiology: Applying an Antihypertensive Drug to Increase Arterial Blood Pressure in Septic Shock.
    Critical care medicine, 2015, Volume: 43, Issue:7

    Topics: Adrenergic alpha-2 Receptor Agonists; Angiotensin II; Animals; Blood Pressure; Clonidine; Female; Hy

2015
Reverse Physiology, i.e., Cellular Versus Integrative Versus Comparative Physiology? α-2 Agonists and Septic Shock.
    Critical care medicine, 2016, Volume: 44, Issue:4

    Topics: Adrenergic alpha-2 Receptor Agonists; Angiotensin II; Animals; Blood Pressure; Clonidine; Female; Hy

2016
Hypotension and bradycardia associated with concomitant tizanidine and lisinopril therapy.
    American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists, 2010, Oct-01, Volume: 67, Issue:19

    Topics: Adrenergic alpha-2 Receptor Agonists; Aged, 80 and over; Angiotensin-Converting Enzyme Inhibitors; B

2010
Prolonged delirium after quetiapine overdose.
    Pediatric emergency care, 2010, Volume: 26, Issue:10

    Topics: Adolescent; Antipsychotic Agents; Cholinergic Antagonists; Clonidine; Cytochrome P-450 CYP3A; Deliri

2010
Bradykinin B2 receptor-dependent enhancement of enalapril-evoked hypotension in ethanol-fed female rats.
    Journal of cardiovascular pharmacology, 2011, Volume: 57, Issue:1

    Topics: Animals; Baroreflex; Bradykinin; Clonidine; Enalapril; Ethanol; Female; Hemodynamics; Hydralazine; H

2011
Intentional clonidine patch ingestion by 3 adults in a detoxification unit.
    Archives of internal medicine, 2003, Feb-10, Volume: 163, Issue:3

    Topics: Administration, Cutaneous; Administration, Oral; Adult; Alcoholic Intoxication; Alprazolam; Antihype

2003
Alpha-adrenergic vascular responsiveness during postexercise hypotension in humans.
    The Journal of physiology, 2003, Jul-01, Volume: 550, Issue:Pt 1

    Topics: Adrenergic alpha-Agonists; Adult; Bicycling; Blood Pressure; Blood Vessels; Clonidine; Exercise; Fem

2003
Antihyperalgesic and side effects of intrathecal clonidine and tizanidine in a rat model of neuropathic pain.
    Anesthesiology, 2003, Volume: 98, Issue:6

    Topics: Adrenergic alpha-Agonists; Analgesics; Animals; Behavior, Animal; Blood Pressure; Bradycardia; Cloni

2003
Levetiracetam as a treatment for tardive dyskinesia: a case report.
    Neurology, 2003, Aug-12, Volume: 61, Issue:3

    Topics: Adrenergic alpha-Agonists; Anticonvulsants; Antidepressive Agents; Chronic Disease; Clonidine; Depre

2003
Effect of ethanol on reductions in norepinephrine electrochemical signal in the rostral ventrolateral medulla and hypotension elicited by I1-receptor activation in spontaneously hypertensive rats.
    Alcoholism, clinical and experimental research, 2003, Volume: 27, Issue:9

    Topics: Animals; Antihypertensive Agents; Blood Pressure; Clonidine; Dose-Response Relationship, Drug; Drug

2003
Intrathecal clonidine and severe hypotension after cardiopulmonary bypass.
    Anesthesia and analgesia, 2003, Volume: 97, Issue:5

    Topics: Adrenergic alpha-Agonists; Cardiopulmonary Bypass; Clonidine; Hemodynamics; Humans; Hypotension; Inj

2003
Synthesis and antihypertensive activity of 1-(2-thiazolyl)-3, 5-disubstituted -2-pyrazolines.
    Archiv der Pharmazie, 2004, Volume: 337, Issue:1

    Topics: Animals; Antihypertensive Agents; Blood Pressure; Clonidine; Hypotension; Injections, Intraperitonea

2004
Clonidine preconditioning decreases infarct size and improves neurological outcome from transient forebrain ischemia in the rat.
    Neuroscience, 2004, Volume: 125, Issue:3

    Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Agon

2004
Hypotensive effects of eugenosedin-A with serotonin, alpha- and beta-adrenoceptor antagonistic activities in spontaneously hypertensive and normotensive rats.
    Pharmacology, 2004, Volume: 71, Issue:2

    Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Animals; Aorta, Thoracic; Binding, Compet

2004
Contrasting effects of chronic ethanol feeding on centrally and peripherally evoked hypotension in telemetered female rats.
    Vascular pharmacology, 2004, Volume: 41, Issue:2

    Topics: Administration, Oral; Animals; Blood Pressure; Clonidine; Drug Administration Schedule; Ethanol; Fem

2004
Chronic ethanol-clonidine hemodynamic interaction in telemetered spontaneously hypertensive rats.
    Vascular pharmacology, 2004, Volume: 41, Issue:3

    Topics: Administration, Oral; Animals; Bradycardia; Clonidine; Delayed-Action Preparations; Drug Administrat

2004
Hypotension due to interaction between lisinopril and tizanidine.
    The Annals of pharmacotherapy, 2004, Volume: 38, Issue:11

    Topics: Angiotensin-Converting Enzyme Inhibitors; Clonidine; Drug Interactions; Female; Humans; Hypotension;

2004
Clonidine poisoning in children: a recent experience.
    Journal of paediatrics and child health, 2004, Volume: 40, Issue:12

    Topics: Adolescent; Analgesics; Australia; Bradycardia; Child; Child, Preschool; Clonidine; Coma; Dose-Respo

2004
Toxic clonidine ingestion in children.
    The Journal of pediatrics, 2005, Volume: 146, Issue:2

    Topics: Analgesics; Bradycardia; Child; Child, Preschool; Clonidine; Coma; Dose-Response Relationship, Drug;

2005
Imidazoline receptors associated with noradrenergic terminals in the rostral ventrolateral medulla mediate the hypotensive responses of moxonidine but not clonidine.
    Neuroscience, 2005, Volume: 132, Issue:4

    Topics: 5,6-Dihydroxytryptamine; Adrenergic Agents; Animals; Antihypertensive Agents; Blotting, Western; Bra

2005
Site-dependent inhibition of neuronal c-jun in the brainstem elicited by imidazoline I1 receptor activation: role in rilmenidine-evoked hypotension.
    European journal of pharmacology, 2005, May-09, Volume: 514, Issue:2-3

    Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Agon

2005
Neuronal norepinephrine responses of the rostral ventrolateral medulla and nucleus tractus solitarius neurons distinguish the I1- from the alpha2-receptor-mediated hypotension in conscious SHRs.
    Journal of cardiovascular pharmacology, 2005, Volume: 46, Issue:1

    Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Agon

2005
More than just an ocular solution.
    Emergency medicine journal : EMJ, 2005, Volume: 22, Issue:10

    Topics: Adrenergic alpha-Agonists; Antihypertensive Agents; Clonidine; Consciousness Disorders; Female; Huma

2005
[Tolerance of the oral clonidine test in 180 patients: efficacy of the volemic expantion in controlling arterial hypotension].
    Arquivos brasileiros de endocrinologia e metabologia, 2005, Volume: 49, Issue:4

    Topics: Adolescent; Adrenergic alpha-Agonists; Adult; Child; Child, Preschool; Clonidine; Disorders of Exces

2005
Central adenosine signaling plays a key role in centrally mediated hypotension in conscious aortic barodenervated rats.
    The Journal of pharmacology and experimental therapeutics, 2006, Volume: 318, Issue:1

    Topics: Adenosine A2 Receptor Agonists; Animals; Aorta; Autonomic Denervation; Blood Pressure; Clonidine; Co

2006
Clonidine ingestion in children is not uneventful.
    The Journal of pediatrics, 2006, Volume: 148, Issue:6

    Topics: Child; Child, Preschool; Clonidine; Humans; Hypoglycemia; Hypotension; Sleep Stages; Unconsciousness

2006
A man with labile blood pressure.
    PLoS medicine, 2007, Volume: 4, Issue:4

    Topics: Baroreflex; Blood Pressure; Clonidine; Humans; Hypertension; Hypotension; Male; Middle Aged

2007
S1P-receptors in PC12 and transfected HEK293 cells: molecular targets of hypotensive imidazoline I(1) receptor ligands.
    Neurochemistry international, 2007, Volume: 51, Issue:8

    Topics: Animals; Antihypertensive Agents; Binding, Competitive; Calcium Signaling; Clonidine; Down-Regulatio

2007
[Acute intoxication with clonidine--a case report].
    Przeglad lekarski, 2007, Volume: 64, Issue:4-5

    Topics: Acute Disease; Adult; Antidotes; Bradycardia; Clonidine; Female; Gastric Lavage; Humans; Hypertensio

2007
Oral hydration during growth hormone stimulation with clonidine.
    Journal of pediatric nursing, 2007, Volume: 22, Issue:5

    Topics: Adolescent; Arginine; Carbonated Beverages; Child; Child, Preschool; Clinical Nursing Research; Clon

2007
Brainstem phosphorylated extracellular signal-regulated kinase 1/2-nitric-oxide synthase signaling mediates the adenosine A2A-dependent hypotensive action of clonidine in conscious aortic barodenervated rats.
    The Journal of pharmacology and experimental therapeutics, 2008, Volume: 324, Issue:1

    Topics: Adenosine A2 Receptor Antagonists; Animals; Antihypertensive Agents; Aorta, Abdominal; Clonidine; De

2008
Tizanidine-induced hypotension in patients with liver cirrhosis.
    European journal of clinical pharmacology, 2008, Volume: 64, Issue:6

    Topics: Aged; Clonidine; Female; Humans; Hypotension; Liver Cirrhosis; Male; Middle Aged; Parasympatholytics

2008
Furter investigations on the interaction between alpha-adrenoceptor antagonists and the central hypotensive effect of clonidine in rats, rabbits and dogs.
    Clinical and experimental pharmacology & physiology, 1980, Volume: 7, Issue:4

    Topics: Adrenergic alpha-Antagonists; Animals; Central Nervous System; Clonidine; Dogs; Drug Interactions; H

1980
Involvement of central alpha 2-adrenoceptors in the mediation of clonidine-induced hypotension in the cat.
    The Journal of pharmacy and pharmacology, 1980, Volume: 32, Issue:11

    Topics: Animals; Blood Pressure; Cats; Clonidine; Female; Hypotension; Prazosin; Receptors, Adrenergic; Rece

1980
Correlations between central hypotensive and peripheral hypertensive effects of structurally dissimilar alpha-adrenoceptor agonists.
    Life sciences, 1981, Feb-09, Volume: 28, Issue:6

    Topics: Adrenergic alpha-Agonists; Animals; Blood Pressure; Clonidine; Dose-Response Relationship, Drug; Hyp

1981
Quantitative aspects of alpha adrenergic effects induced by clonidine-like imidazolidines. I. Central hypotensive and peripheral hypertensive activities.
    The Journal of pharmacology and experimental therapeutics, 1982, Volume: 222, Issue:3

    Topics: Adrenergic alpha-Agonists; Animals; Blood Pressure; Central Nervous System; Clonidine; Hypertension;

1982
Effects of thymoxamine and its metabolites on clonidine-induced hypotension and bradycardia in rats.
    Archives internationales de pharmacodynamie et de therapie, 1982, Volume: 258, Issue:1

    Topics: Anesthesia; Animals; Blood Pressure; Bradycardia; Clonidine; Heart Rate; Hypotension; Male; Moxisyly

1982
The influence of delta 9-tetrahydrocannabinol on intraocular pressure in the anaesthetized cat.
    Documenta ophthalmologica. Advances in ophthalmology, 1980, Apr-15, Volume: 48, Issue:2

    Topics: Animals; Brain Stem; Cats; Clonidine; Dose-Response Relationship, Drug; Dronabinol; Female; Hypotens

1980
Failure of naloxone to reverse clonidine toxic effect.
    American journal of diseases of children (1960), 1983, Volume: 137, Issue:12

    Topics: Bradycardia; Child, Preschool; Clonidine; Female; Humans; Hypotension; Infant; Male; Monitoring, Phy

1983
Symptomatic hypotension following the clonidine suppression test for pheochromocytoma.
    Archives of internal medicine, 1983, Volume: 143, Issue:11

    Topics: Adrenal Gland Neoplasms; Adult; Clonidine; Humans; Hypotension; Male; Pheochromocytoma

1983
Clonidine overdose.
    Critical care medicine, 1983, Volume: 11, Issue:12

    Topics: Bradycardia; Brain; Clonidine; Female; Humans; Hypotension; Hypothermia; Middle Aged

1983
The effects of ouabain in the medullary site of the hypotensive action of clonidine.
    Life sciences, 1984, Jul-23, Volume: 35, Issue:4

    Topics: Animals; Blood Pressure; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Cats; C

1984
Clonidine poisoning. A complex problem.
    American journal of diseases of children (1960), 1983, Volume: 137, Issue:2

    Topics: Apnea; Bradycardia; Child, Preschool; Clonidine; Dopamine; Female; Fluid Therapy; Gastric Lavage; Hu

1983
[Poisoning with clonidin hydrochloride in children and adults].
    Wiener klinische Wochenschrift, 1983, Apr-01, Volume: 95, Issue:7

    Topics: Adolescent; Adult; Bradycardia; Bundle-Branch Block; Child; Child, Preschool; Clonidine; Female; Gas

1983
Accelerated acute clonidine withdrawal syndrome during coronary artery bypass surgery. A case report.
    British journal of anaesthesia, 1981, Volume: 53, Issue:4

    Topics: Acute Disease; Clonidine; Coronary Artery Bypass; Humans; Hypertension; Hypotension; Intraoperative

1981
Comparison of hypotensive, orthostatic and sympathetic inhibitory actions of antihypertensive drugs in rats.
    Clinical and experimental hypertension, 1981, Volume: 3, Issue:2

    Topics: Animals; Antihypertensive Agents; Blood Pressure; Clonidine; Diazepam; Guanethidine; Heart Rate; Hyd

1981
Central nervous system mechanisms involving GABA influence arterial pressure and heart rate in the cat.
    Circulation research, 1980, Volume: 47, Issue:1

    Topics: Animals; Autonomic Nervous System; Blood Pressure; Bradycardia; Cats; Central Nervous System; Clonid

1980
Clonidine and rilmenidine suppress hypotension-induced Fos expression in the lower brainstem of the conscious rabbit.
    Neuroscience, 1995, Volume: 66, Issue:2

    Topics: Animals; Antihypertensive Agents; Blood Pressure; Brain Stem; Clonidine; Consciousness; Female; Hear

1995
Clonidine hypotension in spontaneously hypertensive rats (SHR) depends on the functional state of GABAergic and glutamatergic systems.
    Neuroscience letters, 1995, Jan-23, Volume: 184, Issue:2

    Topics: Animals; Bicuculline; Blood Pressure; Clonidine; Dizocilpine Maleate; GABA-A Receptor Antagonists; H

1995
Relationship between hypotensive effects and plasma concentrations of clonidine in spontaneously hypertensive rats: continuous treatment and sudden termination of clonidine infusion.
    General pharmacology, 1994, Volume: 25, Issue:7

    Topics: Animals; Behavior, Animal; Blood Pressure; Clonidine; Dose-Response Relationship, Drug; Hypotension;

1994
Pretreatment with an intrathecal cholinergic pressor agent: is it necessary?
    Anesthesiology, 1994, Volume: 80, Issue:5

    Topics: Anesthesia, Spinal; Animals; Blood Pressure; Clonidine; Humans; Hypotension; Neostigmine; Premedicat

1994
Corticotropin-releasing factor in the locus coeruleus mediates EEG activation associated with hypotensive stress.
    Neuroscience letters, 1993, Dec-24, Volume: 164, Issue:1-2

    Topics: Animals; Arousal; Clonidine; Corticotropin-Releasing Hormone; Electroencephalography; Hypotension; L

1993
Neural effects on renal blood flow during acute hypotension vary with antihypertensive drugs.
    Hypertension (Dallas, Tex. : 1979), 1994, Volume: 23, Issue:1 Suppl

    Topics: Animals; Antihypertensive Agents; Blood Pressure; Clonidine; Dihydropyridines; Doxazosin; Hypotensio

1994
Clonidine pretreatment reduces the systemic toxicity of intravenous bupivacaine in rats.
    Anesthesiology, 1993, Volume: 79, Issue:2

    Topics: Anesthesia, Epidural; Animals; Arrhythmias, Cardiac; Bupivacaine; Clonidine; Electroencephalography;

1993
Neostigmine counteracts spinal clonidine-induced hypotension in sheep.
    Anesthesiology, 1993, Volume: 78, Issue:2

    Topics: Animals; Clonidine; Female; Hypotension; Injections, Spinal; Neostigmine; Sheep

1993
Preserved sympathetic response to hypotension despite perioperative alpha2 agonist administration.
    Anesthesia and analgesia, 1997, Volume: 84, Issue:6

    Topics: Adjuvants, Anesthesia; Adrenergic alpha-Agonists; Clonidine; Epinephrine; Humans; Hypotension; Intra

1997
A possible clonidine-trazodone-dextroamphetamine interaction in a 12-year-old boy.
    Journal of child and adolescent psychopharmacology, 1996,Fall, Volume: 6, Issue:3

    Topics: Antihypertensive Agents; Bradycardia; Central Nervous System Stimulants; Child; Clonidine; Conscious

1996
Role of cardiac output in ethanol-evoked attenuation of centrally mediated hypotension in conscious rats.
    Hypertension (Dallas, Tex. : 1979), 1997, Volume: 30, Issue:2 Pt 1

    Topics: Animals; Antihypertensive Agents; Brain; Cardiac Output; Clonidine; Ethanol; Hemodynamics; Hydralazi

1997
Safety of alpha2-agonists?
    Anesthesia and analgesia, 1998, Volume: 87, Issue:2

    Topics: Adrenergic alpha-Agonists; Animals; Clonidine; Hemodynamics; Humans; Hypotension; Intraoperative Com

1998
Clonidine overdose.
    Indian pediatrics, 1998, Volume: 35, Issue:11

    Topics: Adrenergic alpha-Agonists; Antihypertensive Agents; Child, Preschool; Clonidine; Drug Overdose; Emer

1998
Influence of sinoaortic barodenervation on the hypotensive effects of imidazoline-like drugs in stroke-prone spontaneously hypertensive rats.
    Annals of the New York Academy of Sciences, 1999, Jun-21, Volume: 881

    Topics: Animals; Antihypertensive Agents; Blood Pressure; Cerebrovascular Disorders; Circadian Rhythm; Cloni

1999
Harmane produces hypotension following microinjection into the RVLM: possible role of I(1)-imidazoline receptors.
    British journal of pharmacology, 2000, Volume: 129, Issue:6

    Topics: Adrenergic alpha-Agonists; Animals; Benzofurans; Blood Pressure; Clonidine; Harmine; Heart Rate; Hyp

2000
Actions of L-NAME and methylene blue on the hypotensive effects of clonidine and rilmenidine in the anesthetized rat.
    Journal of cardiovascular pharmacology, 2000, Volume: 35, Issue:5

    Topics: Anesthesia; Animals; Antihypertensive Agents; Blood Pressure; Clonidine; Cyclic GMP; Drug Interactio

2000
Munchausen's syndrome presenting as baroreflex failure.
    The New England journal of medicine, 2000, Aug-24, Volume: 343, Issue:8

    Topics: Aged; Baroreflex; Clonidine; Diagnosis, Differential; Female; Humans; Hypotension; Munchausen Syndro

2000
Hypotension following the initiation of tizanidine in a patient treated with an angiotensin converting enzyme inhibitor for chronic hypertension.
    Journal of child neurology, 2000, Volume: 15, Issue:12

    Topics: Adrenergic alpha-Agonists; Angiotensin-Converting Enzyme Inhibitors; Child; Clonidine; Drug Interact

2000
Nitric oxide and central antihypertensive drugs: one more difference between catecholamines and imidazolines.
    Hypertension (Dallas, Tex. : 1979), 2001, Volume: 37, Issue:2

    Topics: Animals; Antihypertensive Agents; Blood Pressure; Cardiovascular System; Catecholamines; Clonidine;

2001
Trends and toxic effects from pediatric clonidine exposures.
    Archives of pediatrics & adolescent medicine, 2002, Volume: 156, Issue:4

    Topics: Adolescent; Adrenergic alpha-Agonists; Age Distribution; Attention Deficit Disorder with Hyperactivi

2002
[Hypertension and anesthesia (author's transl)].
    MMW, Munchener medizinische Wochenschrift, 1977, Aug-26, Volume: 119, Issue:34

    Topics: Adrenergic beta-Antagonists; Anesthesia; Antihypertensive Agents; Clonidine; Diazoxide; Dihydralazin

1977
Influence of structural changes in the imidazolidine ring of clonidine on hypotensive activity.
    Pharmacology, 1978, Volume: 16, Issue:2

    Topics: Animals; Antihypertensive Agents; Blood Pressure; Clonidine; Drug Evaluation, Preclinical; Heart Rat

1978
[An analysis of the discrepancy between the effects of central and peripheral alpha-adrenoceptor stimulations (author's transl)].
    Yao xue xue bao = Acta pharmaceutica Sinica, 1979, Volume: 14, Issue:9

    Topics: Animals; Clonidine; gamma-Aminobutyric Acid; Hypotension; Picrotoxin; Rabbits; Receptors, Adrenergic

1979
Centrally induced hypotension unreleated to alpha-adrenergic stimulation.
    Archives internationales de pharmacodynamie et de therapie, 1975, Volume: 213, Issue:2

    Topics: Adrenergic alpha-Agonists; Animals; Arteries; Benzimidazoles; Blood Pressure; Clonidine; Depression,

1975
Clonidine poisoning: is there a single antidote?
    Clinical toxicology, 1979, Volume: 14, Issue:3

    Topics: Antidotes; Bradycardia; Child, Preschool; Clonidine; Dopamine; Gastric Lavage; Humans; Hypotension;

1979
Severe poisoning in a child caused by a small dose of clonidine.
    Clinical toxicology, 1979, Volume: 14, Issue:4

    Topics: Bradycardia; Clonidine; Female; Humans; Hypotension; Infant; Unconsciousness

1979
Effects of acute hypotension and hypertension on serum TSH concentrations in male rats.
    Acta physiologica Scandinavica, 1979, Volume: 107, Issue:2

    Topics: Acute Disease; Angiotensin II; Animals; Clonidine; Dihydralazine; Hypertension; Hypotension; Male; N

1979
[Effects of high doses of clonidine and chlorthalidone].
    La Clinica terapeutica, 1979, Jun-30, Volume: 89, Issue:6

    Topics: Chlorthalidone; Clonidine; Drug Synergism; Female; Humans; Hypertension; Hypotension; Middle Aged

1979
Clonidine withdrawal.
    The Annals of thoracic surgery, 1978, Volume: 25, Issue:2

    Topics: Cardiac Surgical Procedures; Clonidine; Female; Humans; Hypertension; Hypotension; Middle Aged; Subs

1978
Clonidine poisoning with marked hypotension in a 2 1/2-year-old child.
    Clinical pediatrics, 1979, Volume: 18, Issue:2

    Topics: Child, Preschool; Clonidine; Female; Humans; Hypotension; Tolazoline

1979
Letter: Danger in nitroprusside therapy.
    Annals of internal medicine, 1976, Volume: 85, Issue:2

    Topics: Adult; Aged; Clonidine; Ferricyanides; Humans; Hypertension; Hypotension; Male; Nitroprusside

1976
[Clinical effects of a clonidine-chlorthalidone combination in the treatment of arterial hypertension].
    Minerva medica, 1976, Jul-21, Volume: 67, Issue:35

    Topics: Adult; Chlorthalidone; Clonidine; Drug Evaluation; Drug Therapy, Combination; Female; Humans; Hypert

1976
Management in cases of clonidine overdosage.
    The Practitioner, 1976, Volume: 217, Issue:1297

    Topics: Adolescent; Atropine; Blood Pressure; Bradycardia; Clonidine; Diuresis; Female; Humans; Hypotension;

1976
Hypotensive effect of clonidine during sodium depletion in the rat.
    Circulation research, 1975, Volume: 37, Issue:6

    Topics: Animals; Blood Pressure; Clonidine; Disease Models, Animal; Dose-Response Relationship, Drug; Drug S

1975
Evidence for antagonistic activity of endothelin for clonidine induced hypotension and bradycardia.
    Life sciences, 1992, Volume: 50, Issue:2

    Topics: Animals; Blood Pressure; Bradycardia; Clonidine; Depression, Chemical; Endothelins; Heart Rate; Hypo

1992
Effects of clonidine-induced hypotension and dopamine-induced hypertension on blood flows in prostatic adenocarcinoma (Dunning R3327) and normal tissues.
    The Prostate, 1992, Volume: 20, Issue:3

    Topics: Adenocarcinoma; Animals; Blood Pressure; Clonidine; Dopamine; Hypertension; Hypotension; Male; Prost

1992
Case 2--1991. A 50-year-old man undergoing a right thoracotomy experiences unexpected intraoperative hypotension due to a drug interaction.
    Journal of cardiothoracic and vascular anesthesia, 1991, Volume: 5, Issue:2

    Topics: Blood Pressure; Captopril; Clonidine; Drug Interactions; Heart Rate; Humans; Hypotension; Intraopera

1991
Effects of clonidine on renal sympathetic nerve activity and norepinephrine spillover.
    The Journal of pharmacology and experimental therapeutics, 1990, Volume: 254, Issue:3

    Topics: Adrenal Medulla; Animals; Catecholamines; Clonidine; Hemodynamics; Hypotension; Kidney; Male; Nitrop

1990
Clonidine as a sedative adjunct in intensive care.
    Intensive care medicine, 1990, Volume: 16, Issue:4

    Topics: Clonidine; Critical Care; Drug Synergism; Drug Therapy, Combination; Fentanyl; Gastrectomy; Humans;

1990
Intravenous labetalol for the treatment of hypertension after carotid endarterectomy.
    Journal of cardiothoracic anesthesia, 1989, Volume: 3, Issue:4

    Topics: Adrenergic beta-Antagonists; Aged; Blood Pressure; Calcium Channel Blockers; Clonidine; Endarterecto

1989
[Side-effects of the clonidine test in 20 children with short stature].
    Anales espanoles de pediatria, 1989, Volume: 31, Issue:1

    Topics: Adolescent; Child; Child, Preschool; Clonidine; Female; Growth Disorders; Growth Hormone; Heart Rate

1989
Severe hypotension associated with concurrent clonidine and antipsychotic medication.
    The American journal of psychiatry, 1985, Volume: 142, Issue:2

    Topics: Acute Disease; Aged; Antipsychotic Agents; Chlorpromazine; Clonidine; Drug Interactions; Drug Therap

1985
Central nervous system site of action for the hypotensive effect of clonidine in the cat.
    The Journal of pharmacology and experimental therapeutics, 1988, Volume: 245, Issue:1

    Topics: Adrenergic alpha-Antagonists; Animals; Brain; Cats; Clonidine; Female; Heart; Hypotension; Injection

1988
[Participation of peptide mechanisms in physiological reactions of the cardiovascular system to hyperoxia].
    Fiziologicheskii zhurnal SSSR imeni I. M. Sechenova, 1985, Volume: 71, Issue:1

    Topics: Animals; Captopril; Cardiovascular Physiological Phenomena; Cardiovascular System; Clonidine; Enzyme

1985
Clonidine transdermal patch poisoning.
    Annals of emergency medicine, 1988, Volume: 17, Issue:2

    Topics: Accidents, Home; Administration, Cutaneous; Child Care; Clonidine; Humans; Hypotension; Infant; Male

1988
Clonidine overdose and opiate withdrawal.
    Annals of emergency medicine, 1988, Volume: 17, Issue:4

    Topics: Adult; Clonidine; Humans; Hypotension; Male; Naloxone; Substance Withdrawal Syndrome

1988
Epidural clonidine produces antinociception, but not hypotension, in sheep.
    Anesthesiology, 1987, Volume: 66, Issue:4

    Topics: Analgesia; Anesthesia, Epidural; Animals; Clonidine; Dose-Response Relationship, Drug; Female; Hemod

1987
Clonidine modulates the ventrolateral medullary catechol metabolic hyperactivity induced by hypotension.
    Brain research, 1987, Aug-18, Volume: 418, Issue:1

    Topics: Animals; Blood Pressure; Clonidine; Electrochemistry; Heart Rate; Hypotension; Male; Medulla Oblonga

1987
Ventrolateral medullary pressor area: site of hypotensive action of clonidine.
    Brain research, 1987, Oct-06, Volume: 422, Issue:2

    Topics: Animals; Blood Pressure; Clonidine; Dioxanes; Heart Rate; Hypotension; Idazoxan; Male; Medulla Oblon

1987
Tachycardic and hypertensive effects of centrally administered clonidine in conscious rats.
    Clinical and experimental hypertension. Part A, Theory and practice, 1986, Volume: 8, Issue:2

    Topics: Animals; Atropine; Blood Pressure; Bradycardia; Clonidine; Heart Rate; Hypertension; Hypotension; In

1986
Reversal of clonidine toxicity by naloxone.
    Annals of emergency medicine, 1986, Volume: 15, Issue:10

    Topics: Accidents, Traffic; Aged; Clonidine; Female; Humans; Hypertension; Hypotension; Myocardial Infarctio

1986
Effect of clonidine on sympathoadrenal response during sodium nitroprusside hypotension.
    Anesthesia and analgesia, 1986, Volume: 65, Issue:5

    Topics: Animals; Blood Pressure; Clonidine; Dogs; Drug Interactions; Epinephrine; Heart Rate; Hypotension; I

1986
[Clonidine poisoning].
    Padiatrie und Padologie, 1985, Volume: 20, Issue:1

    Topics: Apnea; Arrhythmias, Cardiac; Child, Preschool; Clonidine; Female; Humans; Hypotension; Infant; Male

1985
Multiple roles of nucleus reticularis gigantocellularis in physiologic and pharmacologic regulation of cardiovascular functions.
    Annals of the Academy of Medicine, Singapore, 1985, Volume: 14, Issue:1

    Topics: Animals; Antihypertensive Agents; Cardiovascular Physiological Phenomena; Cardiovascular System; Cat

1985
Clonidine and insulin tests for growth hormone deficiency.
    Archives of disease in childhood, 1985, Volume: 60, Issue:4

    Topics: Child; Clonidine; Female; Growth Disorders; Growth Hormone; Humans; Hypotension

1985
Treatment of hypertension in the elderly.
    Drugs, 1974, Volume: 7, Issue:3

    Topics: Adrenergic beta-Antagonists; Aged; Antihypertensive Agents; Cerebrovascular Disorders; Clonidine; Di

1974
[Clonidin for the treatment of glaucoma in general ophthalmic practice].
    Klinische Monatsblatter fur Augenheilkunde, 1973, Volume: 162, Issue:1

    Topics: Chronic Disease; Clonidine; Glaucoma; Humans; Hypotension; Male; Professional Practice; Vertigo

1973
[The influence of clonidin (isoglaucon) eyedrops on blood pressure, intraocular pressure and cerebral blood flow in healthy persons, hypertonic and glaucoma patients (author's transl)].
    Klinische Monatsblatter fur Augenheilkunde, 1973, Volume: 163, Issue:1

    Topics: Administration, Topical; Arterial Occlusive Diseases; Arteriosclerosis; Blood Pressure; Cerebrovascu

1973