clonidine has been researched along with Hypotension in 156 studies
Clonidine: An imidazoline sympatholytic agent that stimulates ALPHA-2 ADRENERGIC RECEPTORS and central IMIDAZOLINE RECEPTORS. It is commonly used in the management of HYPERTENSION.
clonidine (amino form) : A clonidine that is 4,5-dihydro-1H-imidazol-2-amine in which one of the amino hydrogens is replaced by a 2,6-dichlorophenyl group.
Hypotension: Abnormally low BLOOD PRESSURE that can result in inadequate blood flow to the brain and other vital organs. Common symptom is DIZZINESS but greater negative impacts on the body occur when there is prolonged depravation of oxygen and nutrients.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To determine whether aspirin compared with placebo, and clonidine compared with placebo, alters the risk of perioperative acute kidney injury." | 9.19 | Perioperative aspirin and clonidine and risk of acute kidney injury: a randomized clinical trial. ( Acedillo, R; Amir, M; Bergese, S; Biccard, B; Bidgoli, SJ; Cata, JP; Cegarra, V; Chan, MT; Chan, V; Clanchet, Mde N; Cuerden, M; Devereaux, PJ; Dresser, G; Fleischmann, E; Font, A; Forget, P; Garg, AX; Gomez, MF; Jones, PM; Kumar, P; Kurz, A; Leslie, K; Malaga, G; Martinsen, K; Mehra, B; Meyhoff, CS; Mizera, R; Mrkobrada, M; Myles, P; Painter, T; Parikh, CR; Parlow, J; Pasin, L; Robinson, A; Roshanov, PS; Sessler, DI; Srinathan, S; Tiboni, M; Torres, D; VanHelder, T; Villar, JC; Walsh, M; Whitlock, R; Wijeysundera, DN; Yusuf, S, 2014) |
| "Clonidine premedication prevents tourniquet pain and reduces sympathetic nerve activity." | 9.11 | Oral clonidine premedication exacerbates hypotension following tourniquet deflation by inhibiting noradrenaline release. ( Hongo, T; Kim, C; Kobayashi, N; Maruyama, K; Ogawa, R; Takeda, S, 2004) |
| "8 years) with autistic disorder, diagnosed by DSM-III-R criteria, completed a placebo-controlled, double-blind crossover trial of clonidine." | 9.07 | Clonidine treatment of hyperactive and impulsive children with autistic disorder. ( Cook, EH; Fletcher, KE; Jaselskis, CA; Leventhal, BL, 1992) |
| "Alpha 2-adrenergic receptor changes during antidepressant treatment were studied using 3H-yohimbine binding to human platelet membranes and clonidine-induced hypotension." | 9.06 | Alpha 2-adrenergic receptor sensitivity in depressed patients: relation between 3H-yohimbine binding to platelet membranes and clonidine-induced hypotension. ( Gelenberg, AJ; Lydiard, RB; Wolfe, N, 1989) |
| "Paediatric clonidine poisoning commonly results in bradycardia, hypotension and decreased GCS, but rarely severe or requiring major interventions." | 8.31 | Reality of clonidine poisoning in children and adolescents. ( Downes, MA; Duong, C; Isbister, GK; Lovett, C, 2023) |
| "The agonists of alpha(2)-adrenergic receptors such as clonidine, rilmenidine or monoxidine are known to lower blood pressure (BP) through a reduction of brain sympathetic outflow but their chronic antihypertensive effects in rats with low-renin or high-renin forms of experimental hypertension were not studied yet." | 8.12 | Blood pressure reduction induced by chronic intracerebroventricular or peroral clonidine administration in rats with salt-dependent or angiotensin II-dependent hypertension. ( Behuliak, M; Řezáčová, L; Vaněčková, I; Zicha, J, 2022) |
| "Administration of clonidine during hypotensive sepsis reduced renal sympathetic nerve activity, restored vascular sensitivity to both phenylephrine and angiotensin II, and resulted in better preservation of arterial pressure." | 7.81 | Clonidine Restores Pressor Responsiveness to Phenylephrine and Angiotensin II in Ovine Sepsis. ( Bellomo, R; Booth, LC; Evans, RG; Kosaka, J; Lankadeva, YR; May, CN; Quintin, L, 2015) |
| "Our previous studies showed that chronic ethanol feeding attenuates centrally (clonidine) evoked and potentiates peripherally (hydralazine) evoked hypotension in female rats." | 7.77 | Bradykinin B2 receptor-dependent enhancement of enalapril-evoked hypotension in ethanol-fed female rats. ( Abdel-Rahman, AA; El-Mas, MM, 2011) |
| "A case of severe bradycardia and hypotension associated with concomitant tizanidine and lisinopril therapy is reported." | 7.76 | Hypotension and bradycardia associated with concomitant tizanidine and lisinopril therapy. ( Branam, DL; Publow, SW, 2010) |
| "Clonidine (a mixed alpha2-adrenoceptor and imidazoline I1 receptor agonist)-evoked hypotension was associated with dissimilar reductions in c-jun gene expression in the rostral ventrolateral medulla (RVLM) and the nucleus tractus solitarius (NTS) in normotensive rats." | 7.73 | Site-dependent inhibition of neuronal c-jun in the brainstem elicited by imidazoline I1 receptor activation: role in rilmenidine-evoked hypotension. ( Abdel-Rahman, AA; Li, G; Wang, X, 2005) |
| "To identify cases of clonidine poisoning presenting to a tertiary paediatric hospital and to investigate trends in presentation, outcome and prevention." | 7.72 | Clonidine poisoning in children: a recent experience. ( Cranswick, NE; Sinha, Y, 2004) |
| "To report a case in which significant hypotension occurred after initiation of tizanidine in a patient using the antihypertensive agent lisinopril." | 7.72 | Hypotension due to interaction between lisinopril and tizanidine. ( Chang, JB; Chen, JT; Kao, CD; Liao, KK; Shan, DE; Wu, ZA, 2004) |
| " The authors present a 10-year-old boy chronically treated with lisinopril, an angiotensin converting enzyme inhibitor, to control hypertension who developed hypotension following the addition of tizanidine, an alpha-2 agonist, for the treatment of spasticity." | 7.70 | Hypotension following the initiation of tizanidine in a patient treated with an angiotensin converting enzyme inhibitor for chronic hypertension. ( Johnson, TR; Tobias, JD, 2000) |
| "The effect of gamma-aminobutyric acid (GABA)A receptors and of the N-methyl-D-aspartate (NMDA) subtype of glutamate receptor blockade on clonidine hypotension was studied." | 7.69 | Clonidine hypotension in spontaneously hypertensive rats (SHR) depends on the functional state of GABAergic and glutamatergic systems. ( Czyzewska-Szafran, H; Goźlińska, B; Jastrzebski, Z; Mazurek, AP; Remiszewska, M, 1995) |
| "To test whether neostigmine would alter clonidine-induced hypotension, nine chronically prepared sheep received intrathecal injections of saline or neostigmine (150, 300, 1,000 micrograms) followed in 15 min by 200 micrograms clonidine." | 7.68 | Neostigmine counteracts spinal clonidine-induced hypotension in sheep. ( Eisenach, JC; Tong, C; Williams, JS, 1993) |
| "In the present study it was investigated whether hypertension induced by dopamine or hypotension induced by clonidine could influence the relative blood distribution in a s." | 7.68 | Effects of clonidine-induced hypotension and dopamine-induced hypertension on blood flows in prostatic adenocarcinoma (Dunning R3327) and normal tissues. ( Damber, JE; Grankvist, K; Henriksson, R; Jonsson, O; Widmark, A, 1992) |
| "Intrathecally administered clonidine produces analgesia, but also produces hypotension." | 7.67 | Epidural clonidine produces antinociception, but not hypotension, in sheep. ( Angelo, JM; Dewan, DM; Eisenach, JC; Rose, JC, 1987) |
| "Supplementation of the antihypertensive action of the peripheral vasodilator sodium nitroprusside (SNP) with clonidine, a centrally-acting agent, was studied in ten dogs anesthetized with isoflurane to evaluate the efficacy of clonidine for reducing the amount of SNP required during induced hypotension." | 7.67 | Effect of clonidine on sympathoadrenal response during sodium nitroprusside hypotension. ( Bloor, BC; Finander, LS; Flacke, WE; Van Etten, A, 1986) |
| " Clonidine testing resulted in suppression of plasma norepinephrine levels but was complicated by severe hypotension and a transient ischemic attack." | 7.66 | Symptomatic hypotension following the clonidine suppression test for pheochromocytoma. ( Dzau, VJ; Given, BD; Lilly, LS; Taylor, T, 1983) |
| "Hypotension was significantly more frequent in C30 group (29 versus 3% and 3% in S5 and S10 groups) (p=0,001)." | 6.73 | [30 microg intrathecal clonidine prolongs labour analgesia, but increases the incidence of hypotension and abnormal foetal heart rate patterns]. ( Belhadj Amor, M; Dhahri, S; Draief, A; Ferjani, M; Jebali, A; Lamine, K; Ouezini, R, 2007) |
| "Clonidine pretreatment also caused a more moderate reduction (by 45%) in the number of Fos-positive cells in the nucleus of the solitary tract, but had no effect on Fos expression in the parabrachial nucleus." | 5.29 | Clonidine and rilmenidine suppress hypotension-induced Fos expression in the lower brainstem of the conscious rabbit. ( Dampney, RA; Li, YW, 1995) |
| "Labetalol was administered at the conclusion of surgery as a 20-mg bolus over two minutes followed by 40 mg every 10 minutes until the desired BP was achieved (BP less than or equal to 10% above average preoperative BP or less than 150 mmHg, systolic) or 300 mg had been given." | 5.28 | Intravenous labetalol for the treatment of hypertension after carotid endarterectomy. ( Azad, SS; Goldberg, ME; Larijani, GE; Marr, AT; Seltzer, JL; Smullens, SN, 1989) |
| " Both the groups receiving dexmedetomidine had higher number of patients developing bradycardia as compared to patients receiving clonidine." | 5.22 | Comparision of clonidine and dexmedetomidine for attenuation of laryngoscopy and intubation response - A randomized controlled trial. ( Kakkar, A; Nabi, N; Sethi, AK; Tyagi, A; Verma, UC, 2016) |
| "To determine whether aspirin compared with placebo, and clonidine compared with placebo, alters the risk of perioperative acute kidney injury." | 5.19 | Perioperative aspirin and clonidine and risk of acute kidney injury: a randomized clinical trial. ( Acedillo, R; Amir, M; Bergese, S; Biccard, B; Bidgoli, SJ; Cata, JP; Cegarra, V; Chan, MT; Chan, V; Clanchet, Mde N; Cuerden, M; Devereaux, PJ; Dresser, G; Fleischmann, E; Font, A; Forget, P; Garg, AX; Gomez, MF; Jones, PM; Kumar, P; Kurz, A; Leslie, K; Malaga, G; Martinsen, K; Mehra, B; Meyhoff, CS; Mizera, R; Mrkobrada, M; Myles, P; Painter, T; Parikh, CR; Parlow, J; Pasin, L; Robinson, A; Roshanov, PS; Sessler, DI; Srinathan, S; Tiboni, M; Torres, D; VanHelder, T; Villar, JC; Walsh, M; Whitlock, R; Wijeysundera, DN; Yusuf, S, 2014) |
| "Administration of low-dose clonidine in patients undergoing noncardiac surgery did not reduce the rate of the composite outcome of death or nonfatal myocardial infarction; it did, however, increase the risk of clinically important hypotension and nonfatal cardiac arrest." | 5.19 | Clonidine in patients undergoing noncardiac surgery. ( Alonso-Coello, P; Amir, M; Berwanger, O; Biccard, BM; Botto, F; Chan, MT; Chow, C; Chrolavicius, S; Cook, D; Devereaux, PJ; Eikelboom, J; Fleischmann, E; Forget, P; Gao, P; Garg, AX; Graham, M; Guyatt, G; Kearon, C; Kumar, PA; Kurz, A; Lamy, A; Le Manach, Y; Leslie, K; Lurati Buse, G; Malaga, G; Meyhoff, CS; Mizera, R; Mrkobrada, M; Paniagua, P; Parlow, JL; Pasin, L; Pettit, S; Pogue, J; Robinson, A; Rodseth, RN; Sessler, DI; Sigamani, A; Srinathan, S; Tiboni, M; Torres, D; Vanhelder, T; Villar, JC; Wang, CY; Whitlock, R; Xavier, D; Yusuf, S, 2014) |
| " The addition of clonidine 2 microg/kg to bupivacaine provides a prolonged anesthetic action but may be associated with hypotension." | 5.12 | Clonidine 1 microg/kg is a safe and effective adjuvant to plain bupivacaine in spinal anesthesia in adolescents. ( Abdelaziz, AB; Chattaoui, O; Kaabachi, O; Kokki, H; Ouezini, R; Zarghouni, A, 2007) |
| "Clonidine premedication prevents tourniquet pain and reduces sympathetic nerve activity." | 5.11 | Oral clonidine premedication exacerbates hypotension following tourniquet deflation by inhibiting noradrenaline release. ( Hongo, T; Kim, C; Kobayashi, N; Maruyama, K; Ogawa, R; Takeda, S, 2004) |
| " The hypothesis of this study was that central NE responsivity would predict aggression response to treatment with a NE medication, pindolol." | 5.11 | Noradrenergic activity is associated with response to pindolol in aggressive Alzheimer's disease patients. ( Eryavec, G; Herrmann, N; Khan, LR; Lanctôt, KL, 2004) |
| "Intrathecal administration of bupivacaine and clonidine results in a significant prolongation of both motor and sensitive blocks but side effects-hypotension and bradycardia-are observed." | 5.08 | [Hemodynamic effect of intrathecal clonidine]. ( Bachour, K; Barale, F; Bettinger, G; Koeberlé, P; Rubin, L, 1995) |
| "The results suggest that premedication with clonidine might enhance critical hypotension during anaesthesia and surgery, but restoration both of AP and HR decrease can be achieved effectively by phenylephrine and isoproterenol i." | 5.08 | Clonidine premedication modifies responses to adrenoceptor agonists and baroreflex sensitivity. ( Dohi, S; Iida, H; Ohata, H; Tanabe, K; Watanabe, Y, 1998) |
| "8 years) with autistic disorder, diagnosed by DSM-III-R criteria, completed a placebo-controlled, double-blind crossover trial of clonidine." | 5.07 | Clonidine treatment of hyperactive and impulsive children with autistic disorder. ( Cook, EH; Fletcher, KE; Jaselskis, CA; Leventhal, BL, 1992) |
| "Alpha 2-adrenergic receptor changes during antidepressant treatment were studied using 3H-yohimbine binding to human platelet membranes and clonidine-induced hypotension." | 5.06 | Alpha 2-adrenergic receptor sensitivity in depressed patients: relation between 3H-yohimbine binding to platelet membranes and clonidine-induced hypotension. ( Gelenberg, AJ; Lydiard, RB; Wolfe, N, 1989) |
| " Our review, based on moderate-quality evidence, revealed that hypotension occurred frequently during the preoperative and postoperative periods, for both clonidine and dexmedetomidine." | 5.01 | Perioperative adverse events attributed to α2-adrenoceptor agonists in patients not at risk of cardiovascular events: systematic review and meta-analysis. ( Antunes, T; Demiri, M; Fletcher, D; Martinez, V, 2019) |
| "Clonidine poisoning usually causes depressed sensorium, hypotension, and bradycardia." | 4.76 | Clonidine overdose: report of six cases and review of the literature. ( Anderson, RJ; Crumpler, CP; Hart, GR; Lerman, MJ, 1981) |
| "Paediatric clonidine poisoning commonly results in bradycardia, hypotension and decreased GCS, but rarely severe or requiring major interventions." | 4.31 | Reality of clonidine poisoning in children and adolescents. ( Downes, MA; Duong, C; Isbister, GK; Lovett, C, 2023) |
| "The agonists of alpha(2)-adrenergic receptors such as clonidine, rilmenidine or monoxidine are known to lower blood pressure (BP) through a reduction of brain sympathetic outflow but their chronic antihypertensive effects in rats with low-renin or high-renin forms of experimental hypertension were not studied yet." | 4.12 | Blood pressure reduction induced by chronic intracerebroventricular or peroral clonidine administration in rats with salt-dependent or angiotensin II-dependent hypertension. ( Behuliak, M; Řezáčová, L; Vaněčková, I; Zicha, J, 2022) |
| " Some of the important safety signals included interactions between tizanidine in a suspect or interacting role and ciprofloxacin (ROR for hypotension 28." | 4.12 | A Disproportionality Analysis of Drug-Drug Interactions of Tizanidine and CYP1A2 Inhibitors from the FDA Adverse Event Reporting System (FAERS). ( Boyce, RD; Gómez-Lumbreras, A; Horn, J; Malone, DC; Tan, MS; Villa-Zapata, L, 2022) |
| " However, concomitant use of tizanidine with ciprofloxacin, a strong inhibitor of the P450-CYP1A2 cytochrome metabolic pathway of tizanidine, can result in increased tizanidine plasma levels and associated adverse outcomes, particularly hypotension." | 4.12 | Risk of tizanidine-induced adverse events after concomitant exposure to ciprofloxacin: A cohort study in the U.S. ( Giannouchos, TV; Gómez-Lumbreras, A; Malone, DC, 2022) |
| "Although administration of clonidine is often associated with bradycardia and hypotension, these complications do not seem clinically significant in a mixed PICU population with a high degree of disease severity." | 3.88 | Hemodynamic Tolerance to IV Clonidine Infusion in the PICU. ( de Wildt, SN; Kleiber, N; Tibboel, D; van Rosmalen, J, 2018) |
| "Administration of clonidine during hypotensive sepsis reduced renal sympathetic nerve activity, restored vascular sensitivity to both phenylephrine and angiotensin II, and resulted in better preservation of arterial pressure." | 3.81 | Clonidine Restores Pressor Responsiveness to Phenylephrine and Angiotensin II in Ovine Sepsis. ( Bellomo, R; Booth, LC; Evans, RG; Kosaka, J; Lankadeva, YR; May, CN; Quintin, L, 2015) |
| "Our previous studies showed that chronic ethanol feeding attenuates centrally (clonidine) evoked and potentiates peripherally (hydralazine) evoked hypotension in female rats." | 3.77 | Bradykinin B2 receptor-dependent enhancement of enalapril-evoked hypotension in ethanol-fed female rats. ( Abdel-Rahman, AA; El-Mas, MM, 2011) |
| " In this report, we describe a 15-year-old adolescent girl who experienced continued delirium 5 days after an overdose of quetiapine, trazodone, and clonidine." | 3.76 | Prolonged delirium after quetiapine overdose. ( Pedapati, EV; Rhyee, SH; Thompson, J, 2010) |
| "A case of severe bradycardia and hypotension associated with concomitant tizanidine and lisinopril therapy is reported." | 3.76 | Hypotension and bradycardia associated with concomitant tizanidine and lisinopril therapy. ( Branam, DL; Publow, SW, 2010) |
| "The cellular mechanisms that underlie the enhancement of clonidine-evoked hypotension in aortic barodenervated (ABD) rats and its dependence on central adenosine A(2A) receptor (A(2A)R) are not known." | 3.74 | Brainstem phosphorylated extracellular signal-regulated kinase 1/2-nitric-oxide synthase signaling mediates the adenosine A2A-dependent hypotensive action of clonidine in conscious aortic barodenervated rats. ( Abdel-Rahman, AA; Nassar, N, 2008) |
| "The arginine-clonidine growth hormone (GH) stimulation test causes hypotension, requiring intravenous fluids to stabilize blood pressure (BP) and delaying departure from clinic." | 3.74 | Oral hydration during growth hormone stimulation with clonidine. ( May, M; Rose, SR, 2007) |
| "We tested the hypothesis that clonidine-evoked hypotension is dependent on central adenosinergic pathways." | 3.73 | Central adenosine signaling plays a key role in centrally mediated hypotension in conscious aortic barodenervated rats. ( Abdel-Rahman, AA; Nassar, N, 2006) |
| "Clonidine (a mixed alpha2-adrenoceptor and imidazoline I1 receptor agonist)-evoked hypotension was associated with dissimilar reductions in c-jun gene expression in the rostral ventrolateral medulla (RVLM) and the nucleus tractus solitarius (NTS) in normotensive rats." | 3.73 | Site-dependent inhibition of neuronal c-jun in the brainstem elicited by imidazoline I1 receptor activation: role in rilmenidine-evoked hypotension. ( Abdel-Rahman, AA; Li, G; Wang, X, 2005) |
| "To identify cases of clonidine poisoning presenting to a tertiary paediatric hospital and to investigate trends in presentation, outcome and prevention." | 3.72 | Clonidine poisoning in children: a recent experience. ( Cranswick, NE; Sinha, Y, 2004) |
| "To report a case in which significant hypotension occurred after initiation of tizanidine in a patient using the antihypertensive agent lisinopril." | 3.72 | Hypotension due to interaction between lisinopril and tizanidine. ( Chang, JB; Chen, JT; Kao, CD; Liao, KK; Shan, DE; Wu, ZA, 2004) |
| "Although intrathecal clonidine produces pronounced analgesia, antinociceptive doses of intrathecal clonidine produce several side effects, including hypotension, bradycardia, and sedation." | 3.72 | Antihyperalgesic and side effects of intrathecal clonidine and tizanidine in a rat model of neuropathic pain. ( Kawamata, T; Namiki, A; Omote, K; Toriyabe, M; Wada, K; Yamamoto, H, 2003) |
| " The authors present a 10-year-old boy chronically treated with lisinopril, an angiotensin converting enzyme inhibitor, to control hypertension who developed hypotension following the addition of tizanidine, an alpha-2 agonist, for the treatment of spasticity." | 3.70 | Hypotension following the initiation of tizanidine in a patient treated with an angiotensin converting enzyme inhibitor for chronic hypertension. ( Johnson, TR; Tobias, JD, 2000) |
| "The effect of gamma-aminobutyric acid (GABA)A receptors and of the N-methyl-D-aspartate (NMDA) subtype of glutamate receptor blockade on clonidine hypotension was studied." | 3.69 | Clonidine hypotension in spontaneously hypertensive rats (SHR) depends on the functional state of GABAergic and glutamatergic systems. ( Czyzewska-Szafran, H; Goźlińska, B; Jastrzebski, Z; Mazurek, AP; Remiszewska, M, 1995) |
| " Selective, bilateral LC inactivation by local clonidine infusion prevented EEG activation associated with hypotension." | 3.68 | Corticotropin-releasing factor in the locus coeruleus mediates EEG activation associated with hypotensive stress. ( Berridge, CW; Foote, SL; Page, ME; Valentino, RJ, 1993) |
| "In this model, clonidine given prophylactically delays the toxic manifestations of bupivacaine overdose and does not accentuate the subsequent hypotension." | 3.68 | Clonidine pretreatment reduces the systemic toxicity of intravenous bupivacaine in rats. ( De Kock, M; Henin, D; Le Polain, B; Scholtes, JL; Vandewalle, F, 1993) |
| "To test whether neostigmine would alter clonidine-induced hypotension, nine chronically prepared sheep received intrathecal injections of saline or neostigmine (150, 300, 1,000 micrograms) followed in 15 min by 200 micrograms clonidine." | 3.68 | Neostigmine counteracts spinal clonidine-induced hypotension in sheep. ( Eisenach, JC; Tong, C; Williams, JS, 1993) |
| "In the present study it was investigated whether hypertension induced by dopamine or hypotension induced by clonidine could influence the relative blood distribution in a s." | 3.68 | Effects of clonidine-induced hypotension and dopamine-induced hypertension on blood flows in prostatic adenocarcinoma (Dunning R3327) and normal tissues. ( Damber, JE; Grankvist, K; Henriksson, R; Jonsson, O; Widmark, A, 1992) |
| "Intrathecally administered clonidine produces analgesia, but also produces hypotension." | 3.67 | Epidural clonidine produces antinociception, but not hypotension, in sheep. ( Angelo, JM; Dewan, DM; Eisenach, JC; Rose, JC, 1987) |
| "Intravenous injections of clonidine produce an initial transient increase in blood pressure followed by a long-lasting hypotension and bradycardia." | 3.67 | Ventrolateral medullary pressor area: site of hypotensive action of clonidine. ( Krieger, AJ; Punnen, S; Sapru, HN; Urbanski, R, 1987) |
| "Clonidine is a centrally acting antihypertensive agent used in the management of essential hypertension." | 3.67 | Reversal of clonidine toxicity by naloxone. ( Getzug, T; Murphy, W; Niemann, JT, 1986) |
| "Supplementation of the antihypertensive action of the peripheral vasodilator sodium nitroprusside (SNP) with clonidine, a centrally-acting agent, was studied in ten dogs anesthetized with isoflurane to evaluate the efficacy of clonidine for reducing the amount of SNP required during induced hypotension." | 3.67 | Effect of clonidine on sympathoadrenal response during sodium nitroprusside hypotension. ( Bloor, BC; Finander, LS; Flacke, WE; Van Etten, A, 1986) |
| "A patient with essential hypertension treated with clonidine developed accelerated acute clonidine withdrawal syndrome during coronary artery bypass surgery." | 3.66 | Accelerated acute clonidine withdrawal syndrome during coronary artery bypass surgery. A case report. ( O'Connor, DE, 1981) |
| " Clonidine testing resulted in suppression of plasma norepinephrine levels but was complicated by severe hypotension and a transient ischemic attack." | 3.66 | Symptomatic hypotension following the clonidine suppression test for pheochromocytoma. ( Dzau, VJ; Given, BD; Lilly, LS; Taylor, T, 1983) |
| " Ventilatory support must be available if apnea occurs." | 3.66 | Clonidine poisoning. A complex problem. ( Artman, M; Boerth, RC, 1983) |
| " Contrary to results obtained with clonidine, neither the fall in intraocular pressure (IOP), nor the arterial hypotension induced by delta 9-THC, were enhanced after the 'central' administration of the drug." | 3.66 | The influence of delta 9-tetrahydrocannabinol on intraocular pressure in the anaesthetized cat. ( Hermans, AJ; Innemee, HC; van Zwieten, PA, 1980) |
| " In contradistinction, clonidine caused a dose-related hypotension in conscious unrestrained rats subjected to sodium depletion via furosemide." | 3.65 | Hypotensive effect of clonidine during sodium depletion in the rat. ( Pals, DT, 1975) |
| "Hypotension was significantly more frequent in C30 group (29 versus 3% and 3% in S5 and S10 groups) (p=0,001)." | 2.73 | [30 microg intrathecal clonidine prolongs labour analgesia, but increases the incidence of hypotension and abnormal foetal heart rate patterns]. ( Belhadj Amor, M; Dhahri, S; Draief, A; Ferjani, M; Jebali, A; Lamine, K; Ouezini, R, 2007) |
| "As clonidine was the most effective drug in terms of preservation of pre-operative lung function, it may be clinically advantageous in post-thoracotomy patients." | 2.71 | Epidural clonidine, bupivacaine and methadone as the sole analgesic agent after thoracotomy for lung resection. ( Drenger, B; Gozal, Y; Matot, I; Shauli, A; Weissman, C, 2004) |
| "Significant differences in levels of withdrawal symptoms were found on days 11, 13-15 and 17-20, symptoms resolving most rapidly in the 5-day lofexidine treatment group, whilst withdrawal responses in the 10-day lofexidine treatment group were intermediate between the 5-day lofexidine and standard methadone treatment conditions." | 2.69 | Accelerated lofexidine treatment regimen compared with conventional lofexidine and methadone treatment for in-patient opiate detoxification. ( Bearn, J; Gossop, M; Strang, J, 1998) |
| " This study was performed to evaluate the dose-response hemodynamic and analgesic profiles of intrathecal clonidine administered after a standard surgical intervention, without perioperative administration of additional analgesics, local anesthetics, or tranquilizers." | 2.67 | Hemodynamic and analgesic profile after intrathecal clonidine in humans. A dose-response study. ( Filos, KS; Goudas, LC; Patroni, O; Polyzou, V, 1994) |
| "Clonidine is a central alpha adrenergic agonist which can be used to treat the opiate withdrawal syndrome." | 2.37 | Clonidine and the treatment of the opiate withdrawal syndrome. ( Gossop, M, 1988) |
| " Other reported effects are toxic confusional states and psychotic reactions." | 2.36 | Psychiatric side effects of antihypertensive drugs other than reserpine. ( Fleminger, R; Paykel, ES; Watson, JP, 1982) |
| " These compounds, when dosed of 1." | 1.42 | α-Adrenoceptor antagonistic and hypotensive properties of novel arylpiperazine derivatives of pyrrolidin-2-one. ( Bednarski, M; Dudek, M; Kulig, K; Lustyk, K; Malawska, B; Nowiński, L; Raźny, K; Sapa, J; Siwek, A; Starowicz, G; Zaręba, P, 2015) |
| "Clonidine was associated with the most respiratory (799, 2." | 1.40 | Unintentional pediatric exposures to central alpha-2 agonists reported to the National Poison Data System. ( Heard, K; Le Lait, MC; Wang, GS, 2014) |
| "During septic shock, vasopressors are a cornerstone of therapy." | 1.39 | Clonidine and dexmedetomidine increase the pressor response to norepinephrine in experimental sepsis: a pilot study. ( Chapelier, K; Cividjian, A; Dantony, E; Geloen, A; May, CN; Quintin, L; Rabilloud, M, 2013) |
| "We performed a prospective case series to seek dosage or clinical parameters to better identify patients who need direct medical evaluation." | 1.33 | Toxic clonidine ingestion in children. ( Anderson, DL; Colvin, JM; Johnson, PB; Klein-Schwartz, W; Spiller, HA; Villalobos, D, 2005) |
| "Apraclonidine eye drop is an alpha adrenergic agonist derived topical clonidine, used for the treatment of intraocular pressure elevation." | 1.33 | More than just an ocular solution. ( Karakus, G; Pekdemir, M; Yanturali, S, 2005) |
| "Clonidine hydrochloride is an alpha(2)-adrenergic agonist commonly prescribed as an antihypertensive agent." | 1.32 | Intentional clonidine patch ingestion by 3 adults in a detoxification unit. ( Rapko, DA; Rastegar, DA, 2003) |
| "To analyze the trends, demographics, and toxic effects associated with pediatric clonidine hydrochloride exposures reported to poison centers." | 1.31 | Trends and toxic effects from pediatric clonidine exposures. ( Klein-Schwartz, W, 2002) |
| "The hypotension was caused by decreases in cardiac index and stroke volume because peripheral resistance did not change." | 1.30 | Role of cardiac output in ethanol-evoked attenuation of centrally mediated hypotension in conscious rats. ( Abdel-Rahman, AA; El-Mas, MM, 1997) |
| "1." | 1.29 | Relationship between hypotensive effects and plasma concentrations of clonidine in spontaneously hypertensive rats: continuous treatment and sudden termination of clonidine infusion. ( Ishida, T; Ishii, R; Namba, K; Naruse, T; Tagawa, T, 1994) |
| "Clonidine pretreatment also caused a more moderate reduction (by 45%) in the number of Fos-positive cells in the nucleus of the solitary tract, but had no effect on Fos expression in the parabrachial nucleus." | 1.29 | Clonidine and rilmenidine suppress hypotension-induced Fos expression in the lower brainstem of the conscious rabbit. ( Dampney, RA; Li, YW, 1995) |
| "Labetalol was administered at the conclusion of surgery as a 20-mg bolus over two minutes followed by 40 mg every 10 minutes until the desired BP was achieved (BP less than or equal to 10% above average preoperative BP or less than 150 mmHg, systolic) or 300 mg had been given." | 1.28 | Intravenous labetalol for the treatment of hypertension after carotid endarterectomy. ( Azad, SS; Goldberg, ME; Larijani, GE; Marr, AT; Seltzer, JL; Smullens, SN, 1989) |
| " In toddlers poisoning is seen after ingestion of a single tablet of 150 micrograms clonidine, whilst in adults poisoning may occur already at a dosage just exceeding the therapeutic limit, which is subject to wide individual variation (1 to 3 tablets)." | 1.27 | [Poisoning with clonidin hydrochloride in children and adults]. ( Gössinger, H; Haubenstock, A; Hruby, K; Jung, M; Pfister, R, 1983) |
| "dose, a tachycardia was observed in all rats following initial transient bradycardia." | 1.27 | Tachycardic and hypertensive effects of centrally administered clonidine in conscious rats. ( Imai, Y; Johnston, CI; Nolan, PL, 1986) |
| "Central hypotension is induced by erythro-1-(1-[2-(1,4 - benzodioxan - 2 - yl) - 20H - ET] - 4 - piperidyl) - 2 - benzimidazolinone (R28935), as evidenced by local injections into the cisterna magna of anaesthetized dogs." | 1.25 | Centrally induced hypotension unreleated to alpha-adrenergic stimulation. ( Janssen, PA; Van Nueten, JM; Wellens, S, 1975) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 56 (35.90) | 18.7374 |
| 1990's | 33 (21.15) | 18.2507 |
| 2000's | 39 (25.00) | 29.6817 |
| 2010's | 24 (15.38) | 24.3611 |
| 2020's | 4 (2.56) | 2.80 |
| Authors | Studies |
|---|---|
| Zaręba, P | 1 |
| Dudek, M | 1 |
| Lustyk, K | 1 |
| Siwek, A | 1 |
| Starowicz, G | 1 |
| Bednarski, M | 1 |
| Nowiński, L | 1 |
| Raźny, K | 1 |
| Sapa, J | 1 |
| Malawska, B | 1 |
| Kulig, K | 1 |
| Giannouchos, TV | 1 |
| Gómez-Lumbreras, A | 2 |
| Malone, DC | 2 |
| Villa-Zapata, L | 1 |
| Horn, J | 1 |
| Tan, MS | 1 |
| Boyce, RD | 1 |
| Zicha, J | 3 |
| Řezáčová, L | 3 |
| Behuliak, M | 3 |
| Vaněčková, I | 3 |
| Duong, C | 1 |
| Lovett, C | 1 |
| Downes, MA | 1 |
| Isbister, GK | 1 |
| Demiri, M | 1 |
| Antunes, T | 1 |
| Fletcher, D | 1 |
| Martinez, V | 1 |
| Wang, JG | 1 |
| Belley-Coté, E | 1 |
| Burry, L | 1 |
| Duffett, M | 1 |
| Karachi, T | 1 |
| Perri, D | 1 |
| Alhazzani, W | 1 |
| D'Aragon, F | 1 |
| Wunsch, H | 1 |
| Rochwerg, B | 1 |
| Calzavacca, P | 1 |
| Booth, LC | 2 |
| Lankadeva, YR | 2 |
| Bailey, SR | 1 |
| Burrell, LM | 1 |
| Bailey, M | 1 |
| Bellomo, R | 2 |
| May, CN | 3 |
| Kleiber, N | 1 |
| van Rosmalen, J | 1 |
| Tibboel, D | 1 |
| de Wildt, SN | 1 |
| Chaugai, S | 1 |
| Dickson, AL | 1 |
| Shuey, MM | 1 |
| Feng, Q | 1 |
| Barker, KA | 1 |
| Wei, WQ | 1 |
| Luther, JM | 1 |
| Stein, CM | 1 |
| Chung, CP | 1 |
| Geloen, A | 2 |
| Chapelier, K | 1 |
| Cividjian, A | 1 |
| Dantony, E | 1 |
| Rabilloud, M | 1 |
| Quintin, L | 5 |
| Wang, GS | 1 |
| Le Lait, MC | 1 |
| Heard, K | 1 |
| Dünser, MW | 2 |
| Gradwohl-Matis, I | 2 |
| Vaishnava, P | 1 |
| Eagle, KA | 1 |
| Devereaux, PJ | 2 |
| Sessler, DI | 2 |
| Leslie, K | 2 |
| Kurz, A | 2 |
| Mrkobrada, M | 2 |
| Alonso-Coello, P | 1 |
| Villar, JC | 2 |
| Sigamani, A | 1 |
| Biccard, BM | 1 |
| Meyhoff, CS | 2 |
| Parlow, JL | 1 |
| Guyatt, G | 1 |
| Robinson, A | 2 |
| Garg, AX | 2 |
| Rodseth, RN | 1 |
| Botto, F | 1 |
| Lurati Buse, G | 1 |
| Xavier, D | 1 |
| Chan, MT | 2 |
| Tiboni, M | 2 |
| Cook, D | 1 |
| Kumar, PA | 1 |
| Forget, P | 2 |
| Malaga, G | 2 |
| Fleischmann, E | 2 |
| Amir, M | 2 |
| Eikelboom, J | 1 |
| Mizera, R | 2 |
| Torres, D | 2 |
| Wang, CY | 1 |
| Vanhelder, T | 2 |
| Paniagua, P | 1 |
| Berwanger, O | 1 |
| Srinathan, S | 2 |
| Graham, M | 1 |
| Pasin, L | 2 |
| Le Manach, Y | 1 |
| Gao, P | 1 |
| Pogue, J | 1 |
| Whitlock, R | 2 |
| Lamy, A | 1 |
| Kearon, C | 1 |
| Chow, C | 1 |
| Pettit, S | 1 |
| Chrolavicius, S | 1 |
| Yusuf, S | 2 |
| Geach, T | 1 |
| Treschan, TA | 1 |
| Kienbaum, P | 1 |
| Cuerden, M | 1 |
| Parikh, CR | 1 |
| Jones, PM | 1 |
| Font, A | 1 |
| Cegarra, V | 1 |
| Gomez, MF | 1 |
| Parlow, J | 1 |
| Clanchet, Mde N | 1 |
| Bidgoli, SJ | 1 |
| Martinsen, K | 1 |
| Myles, P | 1 |
| Acedillo, R | 1 |
| Roshanov, PS | 1 |
| Walsh, M | 1 |
| Dresser, G | 1 |
| Kumar, P | 1 |
| Painter, T | 1 |
| Biccard, B | 1 |
| Bergese, S | 1 |
| Cata, JP | 1 |
| Chan, V | 1 |
| Mehra, B | 1 |
| Wijeysundera, DN | 1 |
| Kosaka, J | 1 |
| Evans, RG | 1 |
| Kakkar, A | 1 |
| Tyagi, A | 1 |
| Nabi, N | 1 |
| Sethi, AK | 1 |
| Verma, UC | 1 |
| Nakamura, G | 1 |
| Ganem, EM | 1 |
| Módolo, NS | 1 |
| Rugolo, LM | 1 |
| Castiglia, YM | 1 |
| Publow, SW | 1 |
| Branam, DL | 1 |
| Rhyee, SH | 1 |
| Pedapati, EV | 1 |
| Thompson, J | 1 |
| El-Mas, MM | 4 |
| Abdel-Rahman, AA | 9 |
| Pandazi, A | 1 |
| Karamanis, P | 1 |
| Sidiropoulou, T | 1 |
| Matsota, P | 1 |
| Papasideris, C | 1 |
| Niokou, D | 1 |
| Kostopanagiotou, G | 1 |
| Apostolos, K | 1 |
| Georgios, K | 1 |
| Omiros, C | 1 |
| Christos, T | 1 |
| Blaudszun, G | 1 |
| Lysakowski, C | 1 |
| Elia, N | 1 |
| Tramèr, MR | 1 |
| Rapko, DA | 1 |
| Rastegar, DA | 1 |
| Halliwill, JR | 1 |
| Dinenno, FA | 1 |
| Dietz, NM | 1 |
| Kawamata, T | 1 |
| Omote, K | 1 |
| Yamamoto, H | 1 |
| Toriyabe, M | 1 |
| Wada, K | 1 |
| Namiki, A | 1 |
| McGavin, CL | 1 |
| John, V | 1 |
| Musser, WS | 1 |
| Mao, L | 1 |
| Li, G | 3 |
| Puskas, F | 1 |
| Camporesi, EM | 1 |
| O'Leary, CE | 1 |
| Hauser, M | 1 |
| Nasrallah, FV | 1 |
| Bagheri, M | 1 |
| Shekarchi, M | 1 |
| Jorjani, M | 1 |
| Ghahremani, MH | 1 |
| Vosooghi, M | 1 |
| Shafiee, A | 1 |
| Zhang, Y | 1 |
| Shen, KP | 1 |
| Chiu, CC | 1 |
| Chen, SJ | 1 |
| Chen, IJ | 1 |
| Wu, BN | 1 |
| Maruyama, K | 1 |
| Takeda, S | 1 |
| Hongo, T | 1 |
| Kobayashi, N | 1 |
| Kim, C | 1 |
| Ogawa, R | 1 |
| Herrmann, N | 1 |
| Lanctôt, KL | 1 |
| Eryavec, G | 1 |
| Khan, LR | 1 |
| Matot, I | 1 |
| Drenger, B | 1 |
| Weissman, C | 1 |
| Shauli, A | 1 |
| Gozal, Y | 1 |
| Kao, CD | 1 |
| Chang, JB | 1 |
| Chen, JT | 1 |
| Wu, ZA | 1 |
| Shan, DE | 1 |
| Liao, KK | 1 |
| Sinha, Y | 1 |
| Cranswick, NE | 1 |
| Spiller, HA | 1 |
| Klein-Schwartz, W | 2 |
| Colvin, JM | 1 |
| Villalobos, D | 1 |
| Johnson, PB | 1 |
| Anderson, DL | 1 |
| Chan, CK | 1 |
| Burke, SL | 1 |
| Zhu, H | 1 |
| Piletz, JE | 1 |
| Head, GA | 1 |
| Wang, X | 2 |
| Pekdemir, M | 1 |
| Yanturali, S | 1 |
| Karakus, G | 1 |
| Marui, S | 1 |
| Oliveira, CH | 1 |
| Souza, SC | 1 |
| Berger, K | 1 |
| Khawali, C | 1 |
| Hauache, OM | 1 |
| Maciel, RM | 1 |
| Vieira, JG | 1 |
| Nassar, N | 2 |
| Rachmiel, M | 1 |
| Johnson, T | 1 |
| Daneman, D | 1 |
| Ma, RC | 1 |
| Yiu, KH | 1 |
| Wong, EH | 1 |
| Liu, KH | 1 |
| Chan, JY | 2 |
| Chow, CC | 1 |
| Cockram, CS | 1 |
| Molderings, GJ | 1 |
| Bönisch, H | 1 |
| Brüss, M | 1 |
| Wolf, C | 1 |
| von Kügelgen, I | 1 |
| Göthert, M | 1 |
| Kaabachi, O | 1 |
| Zarghouni, A | 1 |
| Ouezini, R | 2 |
| Abdelaziz, AB | 1 |
| Chattaoui, O | 1 |
| Kokki, H | 1 |
| Hajduk, A | 1 |
| Sein Anand, J | 1 |
| Chodorowski, Z | 1 |
| May, M | 1 |
| Rose, SR | 1 |
| Belhadj Amor, M | 1 |
| Draief, A | 1 |
| Dhahri, S | 1 |
| Jebali, A | 1 |
| Lamine, K | 1 |
| Ferjani, M | 1 |
| Momo, K | 1 |
| Homma, M | 1 |
| Abei, M | 1 |
| Hyodo, I | 1 |
| Kohda, Y | 1 |
| Tsoucaris-Kupfer, D | 1 |
| Bogaievsky, D | 1 |
| Schmitt, H | 1 |
| Hamilton, TC | 1 |
| Hunt, AA | 1 |
| Poyser, RH | 1 |
| Timmermans, PB | 3 |
| van Zwieten, PA | 4 |
| Paykel, ES | 1 |
| Fleminger, R | 1 |
| Watson, JP | 1 |
| de Jonge, A | 1 |
| Bravo, EL | 1 |
| Gifford, RW | 1 |
| Roquebert, J | 1 |
| Demichel, P | 1 |
| Malek, A | 1 |
| Innemee, HC | 1 |
| Hermans, AJ | 1 |
| Zaloga, GP | 1 |
| Hostinsky, C | 1 |
| Chernow, B | 1 |
| Banner, W | 1 |
| Lund, ME | 1 |
| Clawson, L | 1 |
| Given, BD | 1 |
| Taylor, T | 1 |
| Lilly, LS | 1 |
| Dzau, VJ | 1 |
| Marruecos, L | 1 |
| Roglan, A | 1 |
| Frati, ME | 1 |
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| Bousquet, P | 2 |
| Feldman, J | 2 |
| Schwartz, J | 1 |
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| Boerth, RC | 1 |
| Gössinger, H | 1 |
| Hruby, K | 1 |
| Haubenstock, A | 1 |
| Jung, M | 1 |
| Pfister, R | 1 |
| O'Connor, DE | 1 |
| Anderson, RJ | 1 |
| Hart, GR | 1 |
| Crumpler, CP | 1 |
| Lerman, MJ | 1 |
| Baum, T | 1 |
| Sabin, C | 1 |
| Moran, RM | 1 |
| Williford, DJ | 1 |
| Hamilton, BL | 1 |
| Souza, JD | 1 |
| Williams, TP | 1 |
| DiMicco, JA | 1 |
| Gillis, RA | 2 |
| Li, YW | 1 |
| Dampney, RA | 1 |
| De Kock, M | 3 |
| Versailles, H | 1 |
| Colinet, B | 1 |
| Karthaeuser, R | 1 |
| Scholtes, JL | 2 |
| Rubin, L | 1 |
| Koeberlé, P | 1 |
| Bachour, K | 1 |
| Bettinger, G | 1 |
| Barale, F | 1 |
| Johnson, MA | 1 |
| Blackwell, CP | 1 |
| Smith, J | 1 |
| Jastrzebski, Z | 1 |
| Czyzewska-Szafran, H | 1 |
| Goźlińska, B | 1 |
| Remiszewska, M | 1 |
| Mazurek, AP | 1 |
| Naruse, T | 1 |
| Ishida, T | 1 |
| Ishii, R | 1 |
| Tagawa, T | 1 |
| Namba, K | 1 |
| Goudas, LC | 2 |
| Filos, KS | 2 |
| Patroni, O | 1 |
| Polyzou, V | 1 |
| Page, ME | 1 |
| Berridge, CW | 1 |
| Foote, SL | 1 |
| Valentino, RJ | 1 |
| Takishita, S | 1 |
| Muratani, H | 1 |
| Kawazoe, N | 1 |
| Kimura, Y | 1 |
| Tozawa, M | 1 |
| Fukiyama, K | 1 |
| Le Polain, B | 1 |
| Henin, D | 1 |
| Vandewalle, F | 1 |
| Abi-Jaoude, F | 1 |
| Brusset, A | 1 |
| Ceddaha, A | 1 |
| Schlumberger, S | 1 |
| Raffin, L | 1 |
| Dubois, C | 1 |
| Guilmet, D | 1 |
| Fischler, M | 1 |
| Williams, JS | 1 |
| Tong, C | 1 |
| Eisenach, JC | 2 |
| Reinhart, DJ | 1 |
| Wang, W | 1 |
| Stagg, KS | 1 |
| Walker, KG | 1 |
| Bailey, PL | 1 |
| Walker, EB | 1 |
| Zaugg, SE | 1 |
| Singelyn, FJ | 1 |
| Gouverneur, JM | 1 |
| Robert, A | 1 |
| Dodd-o, JM | 1 |
| Breslow, MJ | 1 |
| Dorman, T | 1 |
| Rosenfeld, BA | 1 |
| Bhatara, VS | 1 |
| Kallepalli, BR | 1 |
| Misra, LK | 1 |
| Awadallah, S | 1 |
| Guyenet, PG | 1 |
| Bearn, J | 1 |
| Gossop, M | 2 |
| Strang, J | 1 |
| Ghignone, M | 2 |
| Goyagi, T | 1 |
| Tanaka, M | 1 |
| Nishikawa, T | 1 |
| Watanabe, Y | 1 |
| Iida, H | 1 |
| Tanabe, K | 1 |
| Ohata, H | 1 |
| Dohi, S | 1 |
| Karnawat, BS | 1 |
| Chowdhry, BR | 1 |
| Medvedev, OS | 1 |
| Kunduzova, OR | 1 |
| Murashev, AN | 1 |
| Medvedeva, NA | 1 |
| Musgrave, IF | 1 |
| Badoer, E | 1 |
| Soares de Moura, RS | 1 |
| Leão, MC | 1 |
| Castro Resende, AC | 1 |
| Moreira, CF | 1 |
| Sena, KM | 1 |
| Silveira, SS | 1 |
| Lima, AF | 1 |
| Nunes, FR | 1 |
| Mesquita Ferreira, AG | 1 |
| Tellioglu, T | 1 |
| Oates, JA | 1 |
| Biaggioni, I | 1 |
| Johnson, TR | 1 |
| Tobias, JD | 1 |
| Sy, GY | 1 |
| Bruban, V | 1 |
| Robertson, D | 1 |
| Abdulla, W | 1 |
| Frey, R | 1 |
| Zhang, SS | 1 |
| Wang, LF | 1 |
| Fu, SX | 1 |
| Wellens, S | 1 |
| Van Nueten, JM | 1 |
| Janssen, PA | 1 |
| Mofenson, HC | 1 |
| Greensher, J | 1 |
| Weiss, TE | 1 |
| Neuvonen, PJ | 1 |
| Vilska, J | 1 |
| Keränen, A | 1 |
| Männistö, PT | 1 |
| Kokkonen, J | 1 |
| Ranta, T | 1 |
| Arena, G | 1 |
| Tedesco, V | 1 |
| Spotnitz, HM | 1 |
| Mendoza, JE | 1 |
| Medalie, M | 1 |
| Cohen, IM | 1 |
| Mottet, MM | 1 |
| Francis, GS | 1 |
| Alpert, JS | 1 |
| Antonello, A | 1 |
| Campanini, M | 1 |
| Glorioso, S | 1 |
| Borsatti, A | 1 |
| Todesco, S | 1 |
| Poyner, TF | 1 |
| Gennery, BA | 1 |
| Vasey, RH | 1 |
| Pals, DT | 1 |
| Gulati, A | 1 |
| Jaselskis, CA | 1 |
| Cook, EH | 1 |
| Fletcher, KE | 1 |
| Leventhal, BL | 1 |
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| Wright, PM | 1 |
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| McClune, S | 1 |
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| Moore, J | 1 |
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| Bach, A | 1 |
| Layer, M | 1 |
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| Wolfe, N | 1 |
| Gelenberg, AJ | 1 |
| Lydiard, RB | 1 |
| Goldberg, ME | 1 |
| Seltzer, JL | 1 |
| Azad, SS | 1 |
| Smullens, SN | 1 |
| Marr, AT | 1 |
| Larijani, GE | 1 |
| Durá Trave, T | 1 |
| Moya Benavent, M | 1 |
| Buades Esplá, A | 1 |
| Fruncillo, RJ | 1 |
| Gibbons, WJ | 1 |
| Vlasses, PH | 1 |
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| Getzug, T | 1 |
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| Bloor, BC | 1 |
| Finander, LS | 1 |
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| Deutsch, J | 1 |
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| Beitzke, A | 1 |
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| Lidbrink, P | 1 |
| Conrads, H | 1 |
| Sayegh, F | 1 |
| Hartmann, J | 1 |
| Weigelin, E | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Dexmedetomidine Improve Microcirculatory Alterations in Initial Resuscitated Septic Shock Patients[NCT02270281] | Phase 4 | 44 participants (Actual) | Interventional | 2014-12-31 | Completed | ||
| Low-Dose Dexmedetomidine for Delirium Prevention in Mechanically Ventilated Septic Patients in Intensive Care Unit: a Multi-Center, Randomized, Double-Blind, Placebo-Controlled Trial[NCT04876937] | 116 participants (Anticipated) | Interventional | 2021-05-28 | Recruiting | |||
| A Large, International, Placebo-controlled, Factorial Trial to Assess the Impact of Clonidine and Acetyl-salicylic Acid (ASA) in Patients Undergoing Noncardiac Surgery Who Are at Risk of a Perioperative Cardiovascular Event[NCT01082874] | Phase 3 | 10,010 participants (Actual) | Interventional | 2010-07-31 | Completed | ||
| Effect of Target Intraoperative Blood Pressure on the Incidence of Post-operative Cognitive Dysfunction in Patients Aged 75 and Older Undergoing General Anesthesia for Non-cardiac Surgery: an International Multicenter Randomized Controlled Trial[NCT02428062] | Phase 2/Phase 3 | 1,812 participants (Anticipated) | Interventional | 2014-10-31 | Suspended (stopped due to Pending Pilot study results evaluation) | ||
| Labor Analgesia With Ropivacaine Added to Clonidine. A Randomized Clinical Trial[NCT00626977] | 32 participants (Actual) | Observational | 2000-05-31 | Completed | |||
| A Prospective Study Comparing Total Intravenous Anesthesia With Propofol and Remifentanil vs. Propofol and Dexmedetomidine in Adolescent Idiopathic Scoliosis Patients Undergoing Posterior Spinal Fusion and Instrumentation[NCT06096181] | Phase 2 | 120 participants (Anticipated) | Interventional | 2023-12-31 | Not yet recruiting | ||
| Intravenous Lidocaine and Time to Regression of the Sensory Block After Spinal Anesthesia With Isobaric Bupivacaine in Patients Undergoing Surgery to Treat Skin and Soft Tissue Tumors of the Lower Limbs[NCT04741880] | Phase 2/Phase 3 | 66 participants (Anticipated) | Interventional | 2021-06-17 | Recruiting | ||
| Guanfacine for PONV and Pain After Sinus Surgery[NCT02882854] | 84 participants (Actual) | Interventional | 2016-11-30 | Completed | |||
| A Comparison of Morphine and Morphine Plus Dexmedetomidine in Chronic Cancer Pain[NCT02289261] | Phase 4 | 40 participants (Actual) | Interventional | 2014-11-30 | Completed | ||
| Phase I-II Clinical Trial to Determine the Safety of Clonidine in Infants With Hypoxic Ischemic Encephalopathy During Therapeutic Hypothermia[NCT01862250] | Phase 1/Phase 2 | 13 participants (Actual) | Interventional | 2013-10-03 | Completed | ||
| Effect of Clonidine vs. Dexmedetomidine in Addition to Standard Treatment in Agitated Delirium in Intensive Care Patients: Pilot Study.[NCT04758936] | Phase 4 | 50 participants (Anticipated) | Interventional | 2021-02-01 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
(NCT01082874)
Timeframe: 30 days
| Intervention | participants (Number) |
|---|---|
| Active Clonidine and Active ASA | 173 |
| Active Clonidine and Placebo ASA | 194 |
| Placebo Clonidine and Active ASA | 178 |
| Placebo Clonidine and Placebo ASA | 161 |
(NCT02882854)
Timeframe: Time frame between arrival and discharge in PACU, approximately 90 minutes
| Intervention | minutes (Median) |
|---|---|
| Guanfacine | 128 |
| Placebo | 110 |
PONV assessed using nVRS at 24 hours postop when 0 is no nausea and 10 is worst nausea. (NCT02882854)
Timeframe: 24 hours post op
| Intervention | score on a scale (Median) |
|---|---|
| Guanfacine | 0.00 |
| Placebo | 0.00 |
Postoperative pain assessment using VAS at 24 hours postop when 0 is no pain and 10 is worst pain (NCT02882854)
Timeframe: 24 hours postop
| Intervention | score on a scale (Median) |
|---|---|
| Guanfacine | 3 |
| Placebo | 2 |
Total narcotic requirement in PACU tallied in morphine equivalents during PACU stay (NCT02882854)
Timeframe: Time frame between arrival and discharge in PACU, approximately 90 minutes
| Intervention | morphine equivalents (Median) |
|---|---|
| Guanfacine | 8.75 |
| Placebo | 7.50 |
Maximum postoperative pain assessment assessed in PACU at 15, 30 and 60 minutes after PACU arrival using VAS when 0 is no pain and 10 is worst pain (NCT02882854)
Timeframe: 15, 30, 60 minutes after arriving in PACU
| Intervention | Participants (Count of Participants) | |||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 15 minutes after PACU admission72482977 | 15 minutes after PACU admission72482978 | 30 minutes after PACU admission72482977 | 30 minutes after PACU admission72482978 | 60 minutes after PACU admission72482977 | 60 minutes after PACU admission72482978 | |||||||||||||
| Mild (Pain nVRS 1-5) | Moderate/Severe (Pain nVRS 6-10) | None (Pain nVRS 0) | ||||||||||||||||
| Guanfacine | 31 | |||||||||||||||||
| Placebo | 24 | |||||||||||||||||
| Guanfacine | 0 | |||||||||||||||||
| Placebo | 5 | |||||||||||||||||
| Guanfacine | 8 | |||||||||||||||||
| Placebo | 10 | |||||||||||||||||
| Guanfacine | 18 | |||||||||||||||||
| Placebo | 20 | |||||||||||||||||
| Guanfacine | 7 | |||||||||||||||||
| Placebo | 6 | |||||||||||||||||
| Guanfacine | 14 | |||||||||||||||||
| Placebo | 14 | |||||||||||||||||
| Guanfacine | 12 | |||||||||||||||||
| Placebo | 16 | |||||||||||||||||
| Guanfacine | 6 | |||||||||||||||||
| Placebo | 13 | |||||||||||||||||
| Guanfacine | 21 | |||||||||||||||||
| Placebo | 12 | |||||||||||||||||
Intravenous morphine (mg/kg) was given. The standard dose is 0.05 mg/kg per dose (NCT01862250)
Timeframe: Up to 2 days
| Intervention | mg/kg (Median) |
|---|---|
| Clonidine Infants With HIE | 0.02 |
Babies were assessed after administration of clonidine for the presence or absence of shivering. (NCT01862250)
Timeframe: 48hrs
| Intervention | Participants (Count of Participants) |
|---|---|
| Clonidine Infants With HIE | 0 |
"Trough clonidine blood levels were measured after 4-7 doses of clonidine were given intravenously with a dosing interval of every 8 hrs. Mean and standard deviation (SD) of the number of doses given prior to levels being drawn was 5.3 (mean) and 0.37 (SD).~Time after last dose before measurement was 9hrs (mean) and 2.7hrs (SD)." (NCT01862250)
Timeframe: 3 days
| Intervention | ng/ml (Median) |
|---|---|
| Clonidine Infants With HIE | 0.6 |
Following 2 hours of therapeutic hypothermia, the temperature of the thermo-blanket is adjusted up half degree per hour allowing passive rewarming until 36.5 degrees is reached (NCT01862250)
Timeframe: Beginning at 72 hours up to 12 hours
| Intervention | Hours (Median) |
|---|---|
| Clonidine Infants With HIE | 8.7 |
12 reviews available for clonidine and Hypotension
| Article | Year |
|---|---|
Perioperative adverse events attributed to α2-adrenoceptor agonists in patients not at risk of cardiovascular events: systematic review and meta-analysis.
Topics: Adrenergic alpha-2 Receptor Agonists; Bradycardia; Clonidine; Dexmedetomidine; Humans; Hypotension; | 2019 |
Clonidine for sedation in the critically ill: a systematic review and meta-analysis.
Topics: Clonidine; Critical Illness; Humans; Hypnotics and Sedatives; Hypotension; Intensive Care Units; Len | 2017 |
Effect of perioperative systemic α2 agonists on postoperative morphine consumption and pain intensity: systematic review and meta-analysis of randomized controlled trials.
Topics: Adrenergic alpha-2 Receptor Agonists; Analgesics, Opioid; Anesthesia Recovery Period; Clonidine; Dex | 2012 |
Effect of perioperative systemic α2 agonists on postoperative morphine consumption and pain intensity: systematic review and meta-analysis of randomized controlled trials.
Topics: Adrenergic alpha-2 Receptor Agonists; Analgesics, Opioid; Anesthesia Recovery Period; Clonidine; Dex | 2012 |
Effect of perioperative systemic α2 agonists on postoperative morphine consumption and pain intensity: systematic review and meta-analysis of randomized controlled trials.
Topics: Adrenergic alpha-2 Receptor Agonists; Analgesics, Opioid; Anesthesia Recovery Period; Clonidine; Dex | 2012 |
Effect of perioperative systemic α2 agonists on postoperative morphine consumption and pain intensity: systematic review and meta-analysis of randomized controlled trials.
Topics: Adrenergic alpha-2 Receptor Agonists; Analgesics, Opioid; Anesthesia Recovery Period; Clonidine; Dex | 2012 |
Effect of perioperative systemic α2 agonists on postoperative morphine consumption and pain intensity: systematic review and meta-analysis of randomized controlled trials.
Topics: Adrenergic alpha-2 Receptor Agonists; Analgesics, Opioid; Anesthesia Recovery Period; Clonidine; Dex | 2012 |
Effect of perioperative systemic α2 agonists on postoperative morphine consumption and pain intensity: systematic review and meta-analysis of randomized controlled trials.
Topics: Adrenergic alpha-2 Receptor Agonists; Analgesics, Opioid; Anesthesia Recovery Period; Clonidine; Dex | 2012 |
Effect of perioperative systemic α2 agonists on postoperative morphine consumption and pain intensity: systematic review and meta-analysis of randomized controlled trials.
Topics: Adrenergic alpha-2 Receptor Agonists; Analgesics, Opioid; Anesthesia Recovery Period; Clonidine; Dex | 2012 |
Effect of perioperative systemic α2 agonists on postoperative morphine consumption and pain intensity: systematic review and meta-analysis of randomized controlled trials.
Topics: Adrenergic alpha-2 Receptor Agonists; Analgesics, Opioid; Anesthesia Recovery Period; Clonidine; Dex | 2012 |
Effect of perioperative systemic α2 agonists on postoperative morphine consumption and pain intensity: systematic review and meta-analysis of randomized controlled trials.
Topics: Adrenergic alpha-2 Receptor Agonists; Analgesics, Opioid; Anesthesia Recovery Period; Clonidine; Dex | 2012 |
Effect of perioperative systemic α2 agonists on postoperative morphine consumption and pain intensity: systematic review and meta-analysis of randomized controlled trials.
Topics: Adrenergic alpha-2 Receptor Agonists; Analgesics, Opioid; Anesthesia Recovery Period; Clonidine; Dex | 2012 |
Effect of perioperative systemic α2 agonists on postoperative morphine consumption and pain intensity: systematic review and meta-analysis of randomized controlled trials.
Topics: Adrenergic alpha-2 Receptor Agonists; Analgesics, Opioid; Anesthesia Recovery Period; Clonidine; Dex | 2012 |
Effect of perioperative systemic α2 agonists on postoperative morphine consumption and pain intensity: systematic review and meta-analysis of randomized controlled trials.
Topics: Adrenergic alpha-2 Receptor Agonists; Analgesics, Opioid; Anesthesia Recovery Period; Clonidine; Dex | 2012 |
Effect of perioperative systemic α2 agonists on postoperative morphine consumption and pain intensity: systematic review and meta-analysis of randomized controlled trials.
Topics: Adrenergic alpha-2 Receptor Agonists; Analgesics, Opioid; Anesthesia Recovery Period; Clonidine; Dex | 2012 |
Effect of perioperative systemic α2 agonists on postoperative morphine consumption and pain intensity: systematic review and meta-analysis of randomized controlled trials.
Topics: Adrenergic alpha-2 Receptor Agonists; Analgesics, Opioid; Anesthesia Recovery Period; Clonidine; Dex | 2012 |
Effect of perioperative systemic α2 agonists on postoperative morphine consumption and pain intensity: systematic review and meta-analysis of randomized controlled trials.
Topics: Adrenergic alpha-2 Receptor Agonists; Analgesics, Opioid; Anesthesia Recovery Period; Clonidine; Dex | 2012 |
Effect of perioperative systemic α2 agonists on postoperative morphine consumption and pain intensity: systematic review and meta-analysis of randomized controlled trials.
Topics: Adrenergic alpha-2 Receptor Agonists; Analgesics, Opioid; Anesthesia Recovery Period; Clonidine; Dex | 2012 |
Psychiatric side effects of antihypertensive drugs other than reserpine.
Topics: Adrenergic beta-Antagonists; Antihypertensive Agents; Anxiety; Bethanidine; Clonidine; Debrisoquin; | 1982 |
Current concepts. Pheochromocytoma: diagnosis, localization and management.
Topics: Adrenal Gland Neoplasms; Adrenergic beta-Antagonists; Blood Pressure; Catecholamines; Clonidine; Glu | 1984 |
Endogenous opioid peptides: critical care implications.
Topics: Animals; Body Temperature Regulation; Cardiovascular System; Clonidine; Endorphins; Halothane; Human | 1984 |
Clonidine overdose: report of six cases and review of the literature.
Topics: Adolescent; Adult; Atropine; Bradycardia; Child, Preschool; Clonidine; Dopamine; Female; Humans; Hyp | 1981 |
Is the hypotensive effect of clonidine and related drugs due to imidazoline binding sites?
Topics: Adrenergic alpha-Agonists; Animals; Antihypertensive Agents; Binding Sites; Blood Pressure; Clonidin | 1997 |
Diagnosis and management of baroreflex failure.
Topics: Antihypertensive Agents; Autonomic Nervous System Diseases; Baroreflex; Bradycardia; Carotid Sinus; | 1995 |
Clonidine and the treatment of the opiate withdrawal syndrome.
Topics: Clonidine; Humans; Hypotension; Methadone; Naltrexone; Narcotics; Substance Withdrawal Syndrome | 1988 |
Clonidine, a widow's cruse for pharmacologists.
Topics: Animals; Blood Pressure; Cats; Clonidine; Hypotension; In Vitro Techniques | 1987 |
On the function of central catecholamine neurons--their role in cardiovascular and arousal mechanisms.
Topics: Adrenergic alpha-Antagonists; Animals; Bradycardia; Brain; Cardiovascular Physiological Phenomena; C | 1972 |
24 trials available for clonidine and Hypotension
| Article | Year |
|---|---|
Clonidine in patients undergoing noncardiac surgery.
Topics: Adrenergic alpha-2 Receptor Agonists; Aged; Clonidine; Female; Humans; Hypotension; Kaplan-Meier Est | 2014 |
Clonidine in patients undergoing noncardiac surgery.
Topics: Adrenergic alpha-2 Receptor Agonists; Aged; Clonidine; Female; Humans; Hypotension; Kaplan-Meier Est | 2014 |
Clonidine in patients undergoing noncardiac surgery.
Topics: Adrenergic alpha-2 Receptor Agonists; Aged; Clonidine; Female; Humans; Hypotension; Kaplan-Meier Est | 2014 |
Clonidine in patients undergoing noncardiac surgery.
Topics: Adrenergic alpha-2 Receptor Agonists; Aged; Clonidine; Female; Humans; Hypotension; Kaplan-Meier Est | 2014 |
Perioperative aspirin and clonidine and risk of acute kidney injury: a randomized clinical trial.
Topics: Acute Kidney Injury; Administration, Cutaneous; Administration, Oral; Adrenergic alpha-2 Receptor Ag | 2014 |
Comparision of clonidine and dexmedetomidine for attenuation of laryngoscopy and intubation response - A randomized controlled trial.
Topics: Adolescent; Adrenergic alpha-2 Receptor Agonists; Adult; Anesthesia, General; Blood Pressure; Bradyc | 2016 |
Labor analgesia with ropivacaine added to clonidine: a randomized clinical trial.
Topics: Adult; Amides; Analgesia, Epidural; Analgesia, Obstetrical; Analgesics; Anesthetics, Local; Apgar Sc | 2008 |
Low-dose (1 microg/kg) clonidine premedication and hypotension after carotid artery surgery.
Topics: Adrenergic alpha-2 Receptor Agonists; Aged; Analysis of Variance; Antihypertensive Agents; Blood Pre | 2011 |
Comparison between ropivacaine 1.5 mg ml(-1) plus fentanyl 2 mg ml(-1) and ropivacaine 1.5 mg ml(-1) plus clonidine 1 mg ml(-1) as analgesic solution after anterior cruciate ligament reconstruction: a randomized clinical trial.
Topics: Adrenergic alpha-Agonists; Adult; Amides; Anesthetics, Intravenous; Anesthetics, Local; Anterior Cru | 2011 |
Oral clonidine premedication exacerbates hypotension following tourniquet deflation by inhibiting noradrenaline release.
Topics: Administration, Oral; Adrenergic alpha-Agonists; Adult; Anesthesia, Spinal; Blood Pressure; Clonidin | 2004 |
Noradrenergic activity is associated with response to pindolol in aggressive Alzheimer's disease patients.
Topics: Administration, Oral; Aged; Aged, 80 and over; Aggression; Alzheimer Disease; Behavioral Symptoms; C | 2004 |
Epidural clonidine, bupivacaine and methadone as the sole analgesic agent after thoracotomy for lung resection.
Topics: Adult; Aged; Analgesia, Epidural; Analgesics; Bupivacaine; Clonidine; Double-Blind Method; Female; H | 2004 |
Clonidine 1 microg/kg is a safe and effective adjuvant to plain bupivacaine in spinal anesthesia in adolescents.
Topics: Adjuvants, Pharmaceutic; Adolescent; Anesthesia, Spinal; Bupivacaine; Child; Clonidine; Double-Blind | 2007 |
[30 microg intrathecal clonidine prolongs labour analgesia, but increases the incidence of hypotension and abnormal foetal heart rate patterns].
Topics: Analgesics; Anesthesia, Spinal; Bupivacaine; Clonidine; Dose-Response Relationship, Drug; Female; He | 2007 |
Epidemiology of the adverse hemodynamic events occurring during "clonidine anesthesia": a prospective open trial of intraoperative intravenous clonidine.
Topics: Abdomen; Adrenergic alpha-Agonists; Anesthesia, Inhalation; Anesthesia, Intravenous; Anesthetics, In | 1995 |
[Hemodynamic effect of intrathecal clonidine].
Topics: Aged; Analgesics, Opioid; Anesthesia, Spinal; Anesthetics, Local; Blood Pressure; Bupivacaine; Cloni | 1995 |
Antagonism of the effects of clonidine by the alpha 2-adrenoceptor antagonist, fluparoxan.
Topics: Administration, Oral; Adrenergic alpha-Antagonists; Adult; Antidepressive Agents; Blood Pressure; Br | 1995 |
Hemodynamic and analgesic profile after intrathecal clonidine in humans. A dose-response study.
Topics: Adult; Analgesia, Obstetrical; Blood Pressure; Cesarean Section; Clonidine; Conscious Sedation; Dose | 1994 |
Clonidine premedication for coronary artery bypass grafting under high-dose alfentanil anesthesia: intraoperative and postoperative hemodynamic study.
Topics: Alfentanil; Anesthesia, Intravenous; Blood Pressure; Cardiac Output; Clonidine; Coronary Artery Bypa | 1993 |
Postoperative analgesia after peripheral nerve block for podiatric surgery: clinical efficacy and chemical stability of lidocaine alone versus lidocaine plus clonidine.
Topics: Adrenergic alpha-Agonists; Adult; Analgesia; Analgesics; Analysis of Variance; Anesthetics, Local; A | 1996 |
A minimum dose of clonidine added to mepivacaine prolongs the duration of anesthesia and analgesia after axillary brachial plexus block.
Topics: Adrenergic alpha-Agonists; Adult; Ambulatory Surgical Procedures; Analgesia; Analgesics; Anesthetics | 1996 |
Accelerated lofexidine treatment regimen compared with conventional lofexidine and methadone treatment for in-patient opiate detoxification.
Topics: Adult; Analysis of Variance; Chi-Square Distribution; Clonidine; Dose-Response Relationship, Drug; D | 1998 |
Oral clonidine premedication enhances the pressor response to ephedrine during spinal anesthesia.
Topics: Administration, Oral; Adult; Anesthesia, Spinal; Blood Pressure; Clonidine; Drug Synergism; Ephedrin | 1998 |
Clonidine premedication modifies responses to adrenoceptor agonists and baroreflex sensitivity.
Topics: Adrenergic alpha-Agonists; Adrenergic beta-Agonists; Adult; Anesthesia, General; Baroreflex; Blood P | 1998 |
Clonidine treatment of hyperactive and impulsive children with autistic disorder.
Topics: Ambulatory Care; Attention Deficit Disorder with Hyperactivity; Attitude to Health; Autistic Disorde | 1992 |
Preanaesthetic medication with clonidine.
Topics: Administration, Oral; Adult; Anxiety; Clonidine; Double-Blind Method; Female; Heart Rate; Humans; Hy | 1990 |
Alpha 2-adrenergic receptor sensitivity in depressed patients: relation between 3H-yohimbine binding to platelet membranes and clonidine-induced hypotension.
Topics: Adult; Blood Platelets; Blood Pressure; Cell Membrane; Clinical Trials as Topic; Clonidine; Depressi | 1989 |
120 other studies available for clonidine and Hypotension
| Article | Year |
|---|---|
α-Adrenoceptor antagonistic and hypotensive properties of novel arylpiperazine derivatives of pyrrolidin-2-one.
Topics: Adrenergic alpha-1 Receptor Antagonists; Animals; Dose-Response Relationship, Drug; Hypotension; Mal | 2015 |
Risk of tizanidine-induced adverse events after concomitant exposure to ciprofloxacin: A cohort study in the U.S.
Topics: Ciprofloxacin; Clonidine; Cohort Studies; Drug Interactions; Female; Humans; Hypotension; Middle Age | 2022 |
A Disproportionality Analysis of Drug-Drug Interactions of Tizanidine and CYP1A2 Inhibitors from the FDA Adverse Event Reporting System (FAERS).
Topics: Adverse Drug Reaction Reporting Systems; Ciprofloxacin; Clonidine; Cytochrome P-450 CYP1A2; Cytochro | 2022 |
Blood pressure reduction induced by chronic intracerebroventricular or peroral clonidine administration in rats with salt-dependent or angiotensin II-dependent hypertension.
Topics: Angiotensin II; Animals; Antihypertensive Agents; Blood Pressure; Clonidine; Hypertension; Hypotensi | 2022 |
Blood pressure reduction induced by chronic intracerebroventricular or peroral clonidine administration in rats with salt-dependent or angiotensin II-dependent hypertension.
Topics: Angiotensin II; Animals; Antihypertensive Agents; Blood Pressure; Clonidine; Hypertension; Hypotensi | 2022 |
Blood pressure reduction induced by chronic intracerebroventricular or peroral clonidine administration in rats with salt-dependent or angiotensin II-dependent hypertension.
Topics: Angiotensin II; Animals; Antihypertensive Agents; Blood Pressure; Clonidine; Hypertension; Hypotensi | 2022 |
Blood pressure reduction induced by chronic intracerebroventricular or peroral clonidine administration in rats with salt-dependent or angiotensin II-dependent hypertension.
Topics: Angiotensin II; Animals; Antihypertensive Agents; Blood Pressure; Clonidine; Hypertension; Hypotensi | 2022 |
Blood pressure reduction induced by chronic intracerebroventricular or peroral clonidine administration in rats with salt-dependent or angiotensin II-dependent hypertension.
Topics: Angiotensin II; Animals; Antihypertensive Agents; Blood Pressure; Clonidine; Hypertension; Hypotensi | 2022 |
Blood pressure reduction induced by chronic intracerebroventricular or peroral clonidine administration in rats with salt-dependent or angiotensin II-dependent hypertension.
Topics: Angiotensin II; Animals; Antihypertensive Agents; Blood Pressure; Clonidine; Hypertension; Hypotensi | 2022 |
Blood pressure reduction induced by chronic intracerebroventricular or peroral clonidine administration in rats with salt-dependent or angiotensin II-dependent hypertension.
Topics: Angiotensin II; Animals; Antihypertensive Agents; Blood Pressure; Clonidine; Hypertension; Hypotensi | 2022 |
Blood pressure reduction induced by chronic intracerebroventricular or peroral clonidine administration in rats with salt-dependent or angiotensin II-dependent hypertension.
Topics: Angiotensin II; Animals; Antihypertensive Agents; Blood Pressure; Clonidine; Hypertension; Hypotensi | 2022 |
Blood pressure reduction induced by chronic intracerebroventricular or peroral clonidine administration in rats with salt-dependent or angiotensin II-dependent hypertension.
Topics: Angiotensin II; Animals; Antihypertensive Agents; Blood Pressure; Clonidine; Hypertension; Hypotensi | 2022 |
Reality of clonidine poisoning in children and adolescents.
Topics: Adolescent; Atropine; Bradycardia; Child; Child, Preschool; Clonidine; Female; Humans; Hypotension; | 2023 |
Effects of Clonidine on the Cardiovascular, Renal, and Inflammatory Responses to Experimental Bacteremia.
Topics: Acute Kidney Injury; Animals; Arginine Vasopressin; Bacteremia; Cardiac Output; Clonidine; Disease M | 2019 |
Hemodynamic Tolerance to IV Clonidine Infusion in the PICU.
Topics: Administration, Intravenous; Blood Pressure; Body Temperature; Bradycardia; Child, Preschool; Clonid | 2018 |
Co-Prescription of Strong CYP1A2 Inhibitors and the Risk of Tizanidine-Associated Hypotension: A Retrospective Cohort Study.
Topics: Adult; Clonidine; Cohort Studies; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP1A2 Inhibitors; Drug | 2019 |
Clonidine and dexmedetomidine increase the pressor response to norepinephrine in experimental sepsis: a pilot study.
Topics: Adrenergic alpha-2 Receptor Agonists; Animals; Arterial Pressure; Clonidine; Dexmedetomidine; Hypote | 2013 |
Clonidine and dexmedetomidine increase the pressor response to norepinephrine in experimental sepsis: a pilot study.
Topics: Adrenergic alpha-2 Receptor Agonists; Animals; Arterial Pressure; Clonidine; Dexmedetomidine; Hypote | 2013 |
Clonidine and dexmedetomidine increase the pressor response to norepinephrine in experimental sepsis: a pilot study.
Topics: Adrenergic alpha-2 Receptor Agonists; Animals; Arterial Pressure; Clonidine; Dexmedetomidine; Hypote | 2013 |
Clonidine and dexmedetomidine increase the pressor response to norepinephrine in experimental sepsis: a pilot study.
Topics: Adrenergic alpha-2 Receptor Agonists; Animals; Arterial Pressure; Clonidine; Dexmedetomidine; Hypote | 2013 |
Unintentional pediatric exposures to central alpha-2 agonists reported to the National Poison Data System.
Topics: Adrenergic alpha-2 Receptor Agonists; Bradycardia; Child; Child, Preschool; Clonidine; Female; Guanf | 2014 |
α(2)-agonists to restore adrenergic vasoconstrictor responsiveness in septic shock: thinking outside of the box or fishing in the wrong pond?
Topics: Adrenergic alpha-2 Receptor Agonists; Animals; Arterial Pressure; Clonidine; Dexmedetomidine; Hypote | 2013 |
The yin and yang of perioperative medicine.
Topics: Adrenergic alpha-2 Receptor Agonists; Aspirin; Clonidine; Female; Humans; Hypotension; Male; Myocard | 2014 |
Surgery: Low-dose aspirin and clonidine--no benefit during surgery.
Topics: Adrenergic alpha-2 Receptor Agonists; Aspirin; Clonidine; Female; Humans; Hypotension; Male; Myocard | 2014 |
[Comments on: perioperative administration of clonidine or aspirin].
Topics: Adrenergic alpha-2 Receptor Agonists; Aspirin; Clonidine; Female; Humans; Hypotension; Male; Myocard | 2014 |
Clonidine Restores Pressor Responsiveness to Phenylephrine and Angiotensin II in Ovine Sepsis.
Topics: Adrenergic alpha-2 Receptor Agonists; Angiotensin II; Animals; Blood Pressure; Clonidine; Female; Hy | 2015 |
Reverse Physiology: Applying an Antihypertensive Drug to Increase Arterial Blood Pressure in Septic Shock.
Topics: Adrenergic alpha-2 Receptor Agonists; Angiotensin II; Animals; Blood Pressure; Clonidine; Female; Hy | 2015 |
Reverse Physiology, i.e., Cellular Versus Integrative Versus Comparative Physiology? α-2 Agonists and Septic Shock.
Topics: Adrenergic alpha-2 Receptor Agonists; Angiotensin II; Animals; Blood Pressure; Clonidine; Female; Hy | 2016 |
Hypotension and bradycardia associated with concomitant tizanidine and lisinopril therapy.
Topics: Adrenergic alpha-2 Receptor Agonists; Aged, 80 and over; Angiotensin-Converting Enzyme Inhibitors; B | 2010 |
Prolonged delirium after quetiapine overdose.
Topics: Adolescent; Antipsychotic Agents; Cholinergic Antagonists; Clonidine; Cytochrome P-450 CYP3A; Deliri | 2010 |
Bradykinin B2 receptor-dependent enhancement of enalapril-evoked hypotension in ethanol-fed female rats.
Topics: Animals; Baroreflex; Bradykinin; Clonidine; Enalapril; Ethanol; Female; Hemodynamics; Hydralazine; H | 2011 |
Intentional clonidine patch ingestion by 3 adults in a detoxification unit.
Topics: Administration, Cutaneous; Administration, Oral; Adult; Alcoholic Intoxication; Alprazolam; Antihype | 2003 |
Alpha-adrenergic vascular responsiveness during postexercise hypotension in humans.
Topics: Adrenergic alpha-Agonists; Adult; Bicycling; Blood Pressure; Blood Vessels; Clonidine; Exercise; Fem | 2003 |
Antihyperalgesic and side effects of intrathecal clonidine and tizanidine in a rat model of neuropathic pain.
Topics: Adrenergic alpha-Agonists; Analgesics; Animals; Behavior, Animal; Blood Pressure; Bradycardia; Cloni | 2003 |
Levetiracetam as a treatment for tardive dyskinesia: a case report.
Topics: Adrenergic alpha-Agonists; Anticonvulsants; Antidepressive Agents; Chronic Disease; Clonidine; Depre | 2003 |
Effect of ethanol on reductions in norepinephrine electrochemical signal in the rostral ventrolateral medulla and hypotension elicited by I1-receptor activation in spontaneously hypertensive rats.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Clonidine; Dose-Response Relationship, Drug; Drug | 2003 |
Intrathecal clonidine and severe hypotension after cardiopulmonary bypass.
Topics: Adrenergic alpha-Agonists; Cardiopulmonary Bypass; Clonidine; Hemodynamics; Humans; Hypotension; Inj | 2003 |
Synthesis and antihypertensive activity of 1-(2-thiazolyl)-3, 5-disubstituted -2-pyrazolines.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Clonidine; Hypotension; Injections, Intraperitonea | 2004 |
Clonidine preconditioning decreases infarct size and improves neurological outcome from transient forebrain ischemia in the rat.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Agon | 2004 |
Hypotensive effects of eugenosedin-A with serotonin, alpha- and beta-adrenoceptor antagonistic activities in spontaneously hypertensive and normotensive rats.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Animals; Aorta, Thoracic; Binding, Compet | 2004 |
Contrasting effects of chronic ethanol feeding on centrally and peripherally evoked hypotension in telemetered female rats.
Topics: Administration, Oral; Animals; Blood Pressure; Clonidine; Drug Administration Schedule; Ethanol; Fem | 2004 |
Chronic ethanol-clonidine hemodynamic interaction in telemetered spontaneously hypertensive rats.
Topics: Administration, Oral; Animals; Bradycardia; Clonidine; Delayed-Action Preparations; Drug Administrat | 2004 |
Hypotension due to interaction between lisinopril and tizanidine.
Topics: Angiotensin-Converting Enzyme Inhibitors; Clonidine; Drug Interactions; Female; Humans; Hypotension; | 2004 |
Clonidine poisoning in children: a recent experience.
Topics: Adolescent; Analgesics; Australia; Bradycardia; Child; Child, Preschool; Clonidine; Coma; Dose-Respo | 2004 |
Toxic clonidine ingestion in children.
Topics: Analgesics; Bradycardia; Child; Child, Preschool; Clonidine; Coma; Dose-Response Relationship, Drug; | 2005 |
Imidazoline receptors associated with noradrenergic terminals in the rostral ventrolateral medulla mediate the hypotensive responses of moxonidine but not clonidine.
Topics: 5,6-Dihydroxytryptamine; Adrenergic Agents; Animals; Antihypertensive Agents; Blotting, Western; Bra | 2005 |
Site-dependent inhibition of neuronal c-jun in the brainstem elicited by imidazoline I1 receptor activation: role in rilmenidine-evoked hypotension.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Agon | 2005 |
Neuronal norepinephrine responses of the rostral ventrolateral medulla and nucleus tractus solitarius neurons distinguish the I1- from the alpha2-receptor-mediated hypotension in conscious SHRs.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Agon | 2005 |
More than just an ocular solution.
Topics: Adrenergic alpha-Agonists; Antihypertensive Agents; Clonidine; Consciousness Disorders; Female; Huma | 2005 |
[Tolerance of the oral clonidine test in 180 patients: efficacy of the volemic expantion in controlling arterial hypotension].
Topics: Adolescent; Adrenergic alpha-Agonists; Adult; Child; Child, Preschool; Clonidine; Disorders of Exces | 2005 |
Central adenosine signaling plays a key role in centrally mediated hypotension in conscious aortic barodenervated rats.
Topics: Adenosine A2 Receptor Agonists; Animals; Aorta; Autonomic Denervation; Blood Pressure; Clonidine; Co | 2006 |
Clonidine ingestion in children is not uneventful.
Topics: Child; Child, Preschool; Clonidine; Humans; Hypoglycemia; Hypotension; Sleep Stages; Unconsciousness | 2006 |
A man with labile blood pressure.
Topics: Baroreflex; Blood Pressure; Clonidine; Humans; Hypertension; Hypotension; Male; Middle Aged | 2007 |
S1P-receptors in PC12 and transfected HEK293 cells: molecular targets of hypotensive imidazoline I(1) receptor ligands.
Topics: Animals; Antihypertensive Agents; Binding, Competitive; Calcium Signaling; Clonidine; Down-Regulatio | 2007 |
[Acute intoxication with clonidine--a case report].
Topics: Acute Disease; Adult; Antidotes; Bradycardia; Clonidine; Female; Gastric Lavage; Humans; Hypertensio | 2007 |
Oral hydration during growth hormone stimulation with clonidine.
Topics: Adolescent; Arginine; Carbonated Beverages; Child; Child, Preschool; Clinical Nursing Research; Clon | 2007 |
Brainstem phosphorylated extracellular signal-regulated kinase 1/2-nitric-oxide synthase signaling mediates the adenosine A2A-dependent hypotensive action of clonidine in conscious aortic barodenervated rats.
Topics: Adenosine A2 Receptor Antagonists; Animals; Antihypertensive Agents; Aorta, Abdominal; Clonidine; De | 2008 |
Tizanidine-induced hypotension in patients with liver cirrhosis.
Topics: Aged; Clonidine; Female; Humans; Hypotension; Liver Cirrhosis; Male; Middle Aged; Parasympatholytics | 2008 |
Furter investigations on the interaction between alpha-adrenoceptor antagonists and the central hypotensive effect of clonidine in rats, rabbits and dogs.
Topics: Adrenergic alpha-Antagonists; Animals; Central Nervous System; Clonidine; Dogs; Drug Interactions; H | 1980 |
Involvement of central alpha 2-adrenoceptors in the mediation of clonidine-induced hypotension in the cat.
Topics: Animals; Blood Pressure; Cats; Clonidine; Female; Hypotension; Prazosin; Receptors, Adrenergic; Rece | 1980 |
Correlations between central hypotensive and peripheral hypertensive effects of structurally dissimilar alpha-adrenoceptor agonists.
Topics: Adrenergic alpha-Agonists; Animals; Blood Pressure; Clonidine; Dose-Response Relationship, Drug; Hyp | 1981 |
Quantitative aspects of alpha adrenergic effects induced by clonidine-like imidazolidines. I. Central hypotensive and peripheral hypertensive activities.
Topics: Adrenergic alpha-Agonists; Animals; Blood Pressure; Central Nervous System; Clonidine; Hypertension; | 1982 |
Effects of thymoxamine and its metabolites on clonidine-induced hypotension and bradycardia in rats.
Topics: Anesthesia; Animals; Blood Pressure; Bradycardia; Clonidine; Heart Rate; Hypotension; Male; Moxisyly | 1982 |
The influence of delta 9-tetrahydrocannabinol on intraocular pressure in the anaesthetized cat.
Topics: Animals; Brain Stem; Cats; Clonidine; Dose-Response Relationship, Drug; Dronabinol; Female; Hypotens | 1980 |
Failure of naloxone to reverse clonidine toxic effect.
Topics: Bradycardia; Child, Preschool; Clonidine; Female; Humans; Hypotension; Infant; Male; Monitoring, Phy | 1983 |
Symptomatic hypotension following the clonidine suppression test for pheochromocytoma.
Topics: Adrenal Gland Neoplasms; Adult; Clonidine; Humans; Hypotension; Male; Pheochromocytoma | 1983 |
Clonidine overdose.
Topics: Bradycardia; Brain; Clonidine; Female; Humans; Hypotension; Hypothermia; Middle Aged | 1983 |
The effects of ouabain in the medullary site of the hypotensive action of clonidine.
Topics: Animals; Blood Pressure; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Cats; C | 1984 |
Clonidine poisoning. A complex problem.
Topics: Apnea; Bradycardia; Child, Preschool; Clonidine; Dopamine; Female; Fluid Therapy; Gastric Lavage; Hu | 1983 |
[Poisoning with clonidin hydrochloride in children and adults].
Topics: Adolescent; Adult; Bradycardia; Bundle-Branch Block; Child; Child, Preschool; Clonidine; Female; Gas | 1983 |
Accelerated acute clonidine withdrawal syndrome during coronary artery bypass surgery. A case report.
Topics: Acute Disease; Clonidine; Coronary Artery Bypass; Humans; Hypertension; Hypotension; Intraoperative | 1981 |
Comparison of hypotensive, orthostatic and sympathetic inhibitory actions of antihypertensive drugs in rats.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Clonidine; Diazepam; Guanethidine; Heart Rate; Hyd | 1981 |
Central nervous system mechanisms involving GABA influence arterial pressure and heart rate in the cat.
Topics: Animals; Autonomic Nervous System; Blood Pressure; Bradycardia; Cats; Central Nervous System; Clonid | 1980 |
Clonidine and rilmenidine suppress hypotension-induced Fos expression in the lower brainstem of the conscious rabbit.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Brain Stem; Clonidine; Consciousness; Female; Hear | 1995 |
Clonidine hypotension in spontaneously hypertensive rats (SHR) depends on the functional state of GABAergic and glutamatergic systems.
Topics: Animals; Bicuculline; Blood Pressure; Clonidine; Dizocilpine Maleate; GABA-A Receptor Antagonists; H | 1995 |
Relationship between hypotensive effects and plasma concentrations of clonidine in spontaneously hypertensive rats: continuous treatment and sudden termination of clonidine infusion.
Topics: Animals; Behavior, Animal; Blood Pressure; Clonidine; Dose-Response Relationship, Drug; Hypotension; | 1994 |
Pretreatment with an intrathecal cholinergic pressor agent: is it necessary?
Topics: Anesthesia, Spinal; Animals; Blood Pressure; Clonidine; Humans; Hypotension; Neostigmine; Premedicat | 1994 |
Corticotropin-releasing factor in the locus coeruleus mediates EEG activation associated with hypotensive stress.
Topics: Animals; Arousal; Clonidine; Corticotropin-Releasing Hormone; Electroencephalography; Hypotension; L | 1993 |
Neural effects on renal blood flow during acute hypotension vary with antihypertensive drugs.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Clonidine; Dihydropyridines; Doxazosin; Hypotensio | 1994 |
Clonidine pretreatment reduces the systemic toxicity of intravenous bupivacaine in rats.
Topics: Anesthesia, Epidural; Animals; Arrhythmias, Cardiac; Bupivacaine; Clonidine; Electroencephalography; | 1993 |
Neostigmine counteracts spinal clonidine-induced hypotension in sheep.
Topics: Animals; Clonidine; Female; Hypotension; Injections, Spinal; Neostigmine; Sheep | 1993 |
Preserved sympathetic response to hypotension despite perioperative alpha2 agonist administration.
Topics: Adjuvants, Anesthesia; Adrenergic alpha-Agonists; Clonidine; Epinephrine; Humans; Hypotension; Intra | 1997 |
A possible clonidine-trazodone-dextroamphetamine interaction in a 12-year-old boy.
Topics: Antihypertensive Agents; Bradycardia; Central Nervous System Stimulants; Child; Clonidine; Conscious | 1996 |
Role of cardiac output in ethanol-evoked attenuation of centrally mediated hypotension in conscious rats.
Topics: Animals; Antihypertensive Agents; Brain; Cardiac Output; Clonidine; Ethanol; Hemodynamics; Hydralazi | 1997 |
Safety of alpha2-agonists?
Topics: Adrenergic alpha-Agonists; Animals; Clonidine; Hemodynamics; Humans; Hypotension; Intraoperative Com | 1998 |
Clonidine overdose.
Topics: Adrenergic alpha-Agonists; Antihypertensive Agents; Child, Preschool; Clonidine; Drug Overdose; Emer | 1998 |
Influence of sinoaortic barodenervation on the hypotensive effects of imidazoline-like drugs in stroke-prone spontaneously hypertensive rats.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Cerebrovascular Disorders; Circadian Rhythm; Cloni | 1999 |
Harmane produces hypotension following microinjection into the RVLM: possible role of I(1)-imidazoline receptors.
Topics: Adrenergic alpha-Agonists; Animals; Benzofurans; Blood Pressure; Clonidine; Harmine; Heart Rate; Hyp | 2000 |
Actions of L-NAME and methylene blue on the hypotensive effects of clonidine and rilmenidine in the anesthetized rat.
Topics: Anesthesia; Animals; Antihypertensive Agents; Blood Pressure; Clonidine; Cyclic GMP; Drug Interactio | 2000 |
Munchausen's syndrome presenting as baroreflex failure.
Topics: Aged; Baroreflex; Clonidine; Diagnosis, Differential; Female; Humans; Hypotension; Munchausen Syndro | 2000 |
Hypotension following the initiation of tizanidine in a patient treated with an angiotensin converting enzyme inhibitor for chronic hypertension.
Topics: Adrenergic alpha-Agonists; Angiotensin-Converting Enzyme Inhibitors; Child; Clonidine; Drug Interact | 2000 |
Nitric oxide and central antihypertensive drugs: one more difference between catecholamines and imidazolines.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Cardiovascular System; Catecholamines; Clonidine; | 2001 |
Trends and toxic effects from pediatric clonidine exposures.
Topics: Adolescent; Adrenergic alpha-Agonists; Age Distribution; Attention Deficit Disorder with Hyperactivi | 2002 |
[Hypertension and anesthesia (author's transl)].
Topics: Adrenergic beta-Antagonists; Anesthesia; Antihypertensive Agents; Clonidine; Diazoxide; Dihydralazin | 1977 |
Influence of structural changes in the imidazolidine ring of clonidine on hypotensive activity.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Clonidine; Drug Evaluation, Preclinical; Heart Rat | 1978 |
[An analysis of the discrepancy between the effects of central and peripheral alpha-adrenoceptor stimulations (author's transl)].
Topics: Animals; Clonidine; gamma-Aminobutyric Acid; Hypotension; Picrotoxin; Rabbits; Receptors, Adrenergic | 1979 |
Centrally induced hypotension unreleated to alpha-adrenergic stimulation.
Topics: Adrenergic alpha-Agonists; Animals; Arteries; Benzimidazoles; Blood Pressure; Clonidine; Depression, | 1975 |
Clonidine poisoning: is there a single antidote?
Topics: Antidotes; Bradycardia; Child, Preschool; Clonidine; Dopamine; Gastric Lavage; Humans; Hypotension; | 1979 |
Severe poisoning in a child caused by a small dose of clonidine.
Topics: Bradycardia; Clonidine; Female; Humans; Hypotension; Infant; Unconsciousness | 1979 |
Effects of acute hypotension and hypertension on serum TSH concentrations in male rats.
Topics: Acute Disease; Angiotensin II; Animals; Clonidine; Dihydralazine; Hypertension; Hypotension; Male; N | 1979 |
[Effects of high doses of clonidine and chlorthalidone].
Topics: Chlorthalidone; Clonidine; Drug Synergism; Female; Humans; Hypertension; Hypotension; Middle Aged | 1979 |
Clonidine withdrawal.
Topics: Cardiac Surgical Procedures; Clonidine; Female; Humans; Hypertension; Hypotension; Middle Aged; Subs | 1978 |
Clonidine poisoning with marked hypotension in a 2 1/2-year-old child.
Topics: Child, Preschool; Clonidine; Female; Humans; Hypotension; Tolazoline | 1979 |
Letter: Danger in nitroprusside therapy.
Topics: Adult; Aged; Clonidine; Ferricyanides; Humans; Hypertension; Hypotension; Male; Nitroprusside | 1976 |
[Clinical effects of a clonidine-chlorthalidone combination in the treatment of arterial hypertension].
Topics: Adult; Chlorthalidone; Clonidine; Drug Evaluation; Drug Therapy, Combination; Female; Humans; Hypert | 1976 |
Management in cases of clonidine overdosage.
Topics: Adolescent; Atropine; Blood Pressure; Bradycardia; Clonidine; Diuresis; Female; Humans; Hypotension; | 1976 |
Hypotensive effect of clonidine during sodium depletion in the rat.
Topics: Animals; Blood Pressure; Clonidine; Disease Models, Animal; Dose-Response Relationship, Drug; Drug S | 1975 |
Evidence for antagonistic activity of endothelin for clonidine induced hypotension and bradycardia.
Topics: Animals; Blood Pressure; Bradycardia; Clonidine; Depression, Chemical; Endothelins; Heart Rate; Hypo | 1992 |
Effects of clonidine-induced hypotension and dopamine-induced hypertension on blood flows in prostatic adenocarcinoma (Dunning R3327) and normal tissues.
Topics: Adenocarcinoma; Animals; Blood Pressure; Clonidine; Dopamine; Hypertension; Hypotension; Male; Prost | 1992 |
Case 2--1991. A 50-year-old man undergoing a right thoracotomy experiences unexpected intraoperative hypotension due to a drug interaction.
Topics: Blood Pressure; Captopril; Clonidine; Drug Interactions; Heart Rate; Humans; Hypotension; Intraopera | 1991 |
Effects of clonidine on renal sympathetic nerve activity and norepinephrine spillover.
Topics: Adrenal Medulla; Animals; Catecholamines; Clonidine; Hemodynamics; Hypotension; Kidney; Male; Nitrop | 1990 |
Clonidine as a sedative adjunct in intensive care.
Topics: Clonidine; Critical Care; Drug Synergism; Drug Therapy, Combination; Fentanyl; Gastrectomy; Humans; | 1990 |
Intravenous labetalol for the treatment of hypertension after carotid endarterectomy.
Topics: Adrenergic beta-Antagonists; Aged; Blood Pressure; Calcium Channel Blockers; Clonidine; Endarterecto | 1989 |
[Side-effects of the clonidine test in 20 children with short stature].
Topics: Adolescent; Child; Child, Preschool; Clonidine; Female; Growth Disorders; Growth Hormone; Heart Rate | 1989 |
Severe hypotension associated with concurrent clonidine and antipsychotic medication.
Topics: Acute Disease; Aged; Antipsychotic Agents; Chlorpromazine; Clonidine; Drug Interactions; Drug Therap | 1985 |
Central nervous system site of action for the hypotensive effect of clonidine in the cat.
Topics: Adrenergic alpha-Antagonists; Animals; Brain; Cats; Clonidine; Female; Heart; Hypotension; Injection | 1988 |
[Participation of peptide mechanisms in physiological reactions of the cardiovascular system to hyperoxia].
Topics: Animals; Captopril; Cardiovascular Physiological Phenomena; Cardiovascular System; Clonidine; Enzyme | 1985 |
Clonidine transdermal patch poisoning.
Topics: Accidents, Home; Administration, Cutaneous; Child Care; Clonidine; Humans; Hypotension; Infant; Male | 1988 |
Clonidine overdose and opiate withdrawal.
Topics: Adult; Clonidine; Humans; Hypotension; Male; Naloxone; Substance Withdrawal Syndrome | 1988 |
Epidural clonidine produces antinociception, but not hypotension, in sheep.
Topics: Analgesia; Anesthesia, Epidural; Animals; Clonidine; Dose-Response Relationship, Drug; Female; Hemod | 1987 |
Clonidine modulates the ventrolateral medullary catechol metabolic hyperactivity induced by hypotension.
Topics: Animals; Blood Pressure; Clonidine; Electrochemistry; Heart Rate; Hypotension; Male; Medulla Oblonga | 1987 |
Ventrolateral medullary pressor area: site of hypotensive action of clonidine.
Topics: Animals; Blood Pressure; Clonidine; Dioxanes; Heart Rate; Hypotension; Idazoxan; Male; Medulla Oblon | 1987 |
Tachycardic and hypertensive effects of centrally administered clonidine in conscious rats.
Topics: Animals; Atropine; Blood Pressure; Bradycardia; Clonidine; Heart Rate; Hypertension; Hypotension; In | 1986 |
Reversal of clonidine toxicity by naloxone.
Topics: Accidents, Traffic; Aged; Clonidine; Female; Humans; Hypertension; Hypotension; Myocardial Infarctio | 1986 |
Effect of clonidine on sympathoadrenal response during sodium nitroprusside hypotension.
Topics: Animals; Blood Pressure; Clonidine; Dogs; Drug Interactions; Epinephrine; Heart Rate; Hypotension; I | 1986 |
[Clonidine poisoning].
Topics: Apnea; Arrhythmias, Cardiac; Child, Preschool; Clonidine; Female; Humans; Hypotension; Infant; Male | 1985 |
Multiple roles of nucleus reticularis gigantocellularis in physiologic and pharmacologic regulation of cardiovascular functions.
Topics: Animals; Antihypertensive Agents; Cardiovascular Physiological Phenomena; Cardiovascular System; Cat | 1985 |
Clonidine and insulin tests for growth hormone deficiency.
Topics: Child; Clonidine; Female; Growth Disorders; Growth Hormone; Humans; Hypotension | 1985 |
Treatment of hypertension in the elderly.
Topics: Adrenergic beta-Antagonists; Aged; Antihypertensive Agents; Cerebrovascular Disorders; Clonidine; Di | 1974 |
[Clonidin for the treatment of glaucoma in general ophthalmic practice].
Topics: Chronic Disease; Clonidine; Glaucoma; Humans; Hypotension; Male; Professional Practice; Vertigo | 1973 |
[The influence of clonidin (isoglaucon) eyedrops on blood pressure, intraocular pressure and cerebral blood flow in healthy persons, hypertonic and glaucoma patients (author's transl)].
Topics: Administration, Topical; Arterial Occlusive Diseases; Arteriosclerosis; Blood Pressure; Cerebrovascu | 1973 |