clonidine has been researched along with Hypotension, Postural in 42 studies
Clonidine: An imidazoline sympatholytic agent that stimulates ALPHA-2 ADRENERGIC RECEPTORS and central IMIDAZOLINE RECEPTORS. It is commonly used in the management of HYPERTENSION.
clonidine (amino form) : A clonidine that is 4,5-dihydro-1H-imidazol-2-amine in which one of the amino hydrogens is replaced by a 2,6-dichlorophenyl group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Lofexidine is an analogue of clonidine, an agonist at the alpha 2 noradrenergic receptor." | 2.68 | Double-blind randomised controlled trial of lofexidine versus clonidine in the treatment of heroin withdrawal. ( Hu, WH; Lin, SK; Strang, J; Su, LW; Tsai, CJ, 1997) |
| "Both hypertension and orthostatic hypotension (OH) are strongly age-associated and are common management problems in older people." | 2.55 | Orthostatic hypotension: pathophysiology, assessment, treatment and the paradox of supine hypertension. ( Anpalahan, M; Chisholm, P, 2017) |
| "This led to successfully oral treatment of the orthostatic hypotension with clonidine 150 micrograms bd and midodrine 10 mg bd." | 1.28 | Pharmacological evidence of alpha 1- and alpha 2-adrenergic supersensitivity in orthostatic hypotension due to spinal cord injury: a case report. ( Arias, A; Berlan, M; Montastruc, JL; Rascol, A; Senard, JM; Tran, MA, 1991) |
| "Clonidine has some central component for induction of postural hypotension in addition to the frequency-related peripheral component." | 1.28 | Evaluation of the central and peripheral components for induction of postural hypotension by guanethidine, clonidine, dopamine2 receptor agonists and 5-hydroxytryptamine1A receptor agonists. ( Cannon, JG; Long, JP; Park, KH, 1991) |
| "Patients with mitral valve prolapse syndrome (MVPS), vasoregulatory asthenia, and poor postural adjustment often have orthostatic intolerance characterized by tachycardia and a narrow pulse pressure on standing." | 1.27 | Effects of long-term clonidine administration on the hemodynamic and neuroendocrine postural responses of patients with dysautonomia. ( Blomqvist, CG; Gaffney, FA; Lane, LB; Pettinger, W, 1983) |
| " Full PH dose-response curves for standard antihypertensive drugs were explored and were compared to their hypotensive dose-response curves." | 1.27 | Antihypertensive drugs: their postural hypotensive effect and their blood pressure lowering activity in conscious normotensive rats. ( Carver, LA; Lee, CH; Strosberg, AM, 1983) |
| "The other two patients with idiopathic orthostatic hypotension had an even greater pressor response to 0." | 1.27 | Clonidine raises blood pressure in severe idiopathic orthostatic hypotension. ( Goldberg, MR; Hollister, AS; Robertson, D; Robertson, RM; Wade, D, 1983) |
| "Diabetic patients with diabetic autonomic neuropathy and orthostatic hypotension had a 30-40% decrease in number of platelet alpha 2-adrenergic receptors, as demonstrated by [3H]clonidine and [3H]yohimbine binding." | 1.27 | Decreased alpha 2-adrenergic receptors on platelet membranes from diabetic patients with autonomic neuropathy and orthostatic hypotension. ( Abrahm, DR; Hollingsworth, PJ; Jim, L; Smith, CB; Sobotka, PA; Vinik, AI; Zucker, LB, 1986) |
| "Occasional or recurrent episodes of orthostatic hypotension were observed in 58 out of 584 hypertensive patients treated with alpha-methyldopa, beta-blockers and clonidine alone or associated with diuretics and/or hydralazine and/or reserpine." | 1.26 | [The orthostatic hypotension in patients treated with antihypertensive drugs (author's transl)]. ( Dal Palù, C; Pessina, AC; Pigato, R, 1977) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 23 (54.76) | 18.7374 |
| 1990's | 11 (26.19) | 18.2507 |
| 2000's | 5 (11.90) | 29.6817 |
| 2010's | 2 (4.76) | 24.3611 |
| 2020's | 1 (2.38) | 2.80 |
| Authors | Studies |
|---|---|
| Farrell, MC | 1 |
| Biaggioni, I | 2 |
| Shibao, CA | 1 |
| Chisholm, P | 1 |
| Anpalahan, M | 1 |
| Sheriff, DD | 1 |
| Nådland, IH | 1 |
| Toska, K | 1 |
| Shibao, C | 1 |
| Gamboa, A | 1 |
| Abraham, R | 1 |
| Raj, SR | 1 |
| Diedrich, A | 1 |
| Black, B | 1 |
| Robertson, D | 4 |
| Jordan, J | 1 |
| Weiss, RJ | 1 |
| Dix, BR | 1 |
| Kissner, PZ | 1 |
| Smith, CB | 2 |
| Selmi, W | 1 |
| Matricardi, L | 1 |
| Cavero, I | 1 |
| Roach, AG | 1 |
| Gaffney, FA | 1 |
| Lane, LB | 1 |
| Pettinger, W | 1 |
| Blomqvist, CG | 1 |
| Lee, CH | 1 |
| Strosberg, AM | 1 |
| Carver, LA | 1 |
| da Costa, DF | 1 |
| Bannister, R | 1 |
| Landon, J | 1 |
| Mathias, CJ | 2 |
| Young, E | 1 |
| Levey, BA | 1 |
| Shapiro, AP | 1 |
| Goldberg, MR | 3 |
| Hollister, AS | 3 |
| Wade, D | 1 |
| Robertson, RM | 3 |
| Caris, TN | 1 |
| Meiler, SM | 1 |
| Moskalenko, NP | 1 |
| Tashkan, SE | 1 |
| Puybasset, L | 1 |
| Lacolley, P | 1 |
| Laurent, S | 1 |
| Mignon, F | 1 |
| Billaud, E | 1 |
| Cuche, JL | 1 |
| Comoy, E | 1 |
| Safar, M | 1 |
| Schwartz, GL | 1 |
| Schirger, A | 1 |
| Tongia, SK | 1 |
| Lin, SK | 1 |
| Strang, J | 1 |
| Su, LW | 1 |
| Tsai, CJ | 1 |
| Hu, WH | 1 |
| Kimber, J | 1 |
| Watson, L | 1 |
| Brahmbhatt, R | 1 |
| Baggaley, P | 1 |
| Hockings, B | 1 |
| Victor, RG | 1 |
| Talman, WT | 1 |
| Kara, T | 1 |
| Somers, VK | 1 |
| Pessina, AC | 1 |
| Pigato, R | 1 |
| Dal Palù, C | 1 |
| Moore, MA | 1 |
| Phillipi, P | 1 |
| Sternon, J | 1 |
| Nolan, PL | 1 |
| Bentley, GA | 1 |
| Curtis, JR | 1 |
| Bateman, FJ | 1 |
| Cortelli, P | 1 |
| Parchi, P | 1 |
| Contin, M | 1 |
| Sforza, E | 1 |
| Lugaresi, A | 1 |
| Pasquali, R | 1 |
| Lugaresi, E | 1 |
| Blétry, O | 1 |
| Senard, JM | 1 |
| Arias, A | 1 |
| Berlan, M | 1 |
| Tran, MA | 1 |
| Rascol, A | 1 |
| Montastruc, JL | 1 |
| Park, KH | 1 |
| Long, JP | 1 |
| Cannon, JG | 1 |
| Iankin, VV | 1 |
| Vedrova, NN | 1 |
| Nefedova, IV | 1 |
| Acott, PD | 1 |
| Cole, DE | 1 |
| Finley, JP | 1 |
| Gravier, C | 1 |
| Onrot, J | 1 |
| Wiley, R | 1 |
| Thompson, JG | 1 |
| Abrahm, DR | 1 |
| Hollingsworth, PJ | 1 |
| Jim, L | 1 |
| Zucker, LB | 1 |
| Sobotka, PA | 1 |
| Vinik, AI | 1 |
| Giannini, AJ | 1 |
| Pascarzi, GA | 1 |
| Loiselle, RH | 1 |
| Price, WA | 1 |
| Giannini, MC | 1 |
| Tung, CS | 1 |
| Lagrue, G | 1 |
| Weil, B | 1 |
| Buisson, C | 1 |
| McNay, JL | 1 |
| Amery, AK | 1 |
| Bossaert, H | 1 |
| Fagard, RH | 1 |
| Verstraete, M | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| The Pathophysiology and Treatment of Supine Hypertension in Patients With Autonomic Failure[NCT00223717] | Phase 1 | 152 participants (Actual) | Interventional | 2001-01-31 | Completed | ||
| Dose Response to the Norepinephrine Precursor Droxidopa in Hypotensive Individuals With Spinal Cord Injury[NCT03602014] | Phase 4 | 22 participants (Actual) | Interventional | 2018-06-01 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
4 reviews available for clonidine and Hypotension, Postural
| Article | Year |
|---|---|
Orthostatic hypotension: pathophysiology, assessment, treatment and the paradox of supine hypertension.
Topics: Antihypertensive Agents; Antiparkinson Agents; Clonidine; Disease Management; Domperidone; Dopamine | 2017 |
[Side effects of hypotensive agents].
Topics: Adrenergic beta-Antagonists; Antihypertensive Agents; Benzothiadiazines; Bradycardia; Clonidine; Deh | 1982 |
The pharmacology of prazosin, a novel antihypertensive agent.
Topics: Adrenal Glands; Animals; Antihypertensive Agents; Brain; Clonidine; Dogs; Heart Rate; Humans; Hypote | 1980 |
[Etiological aspects of orthostatic hypotension].
Topics: Blood Pressure Determination; Catecholamines; Clinical Protocols; Clonidine; Decision Trees; Diagnos | 1992 |
6 trials available for clonidine and Hypotension, Postural
| Article | Year |
|---|---|
Clonidine for the treatment of supine hypertension and pressure natriuresis in autonomic failure.
Topics: Aged; Aged, 80 and over; Antihypertensive Agents; Autonomic Nervous System; Autonomic Nervous System | 2006 |
Effects of clonidine on plasma catecholamines and neuropeptide Y in hypertensive patients at rest and during stress.
Topics: Adult; Catecholamines; Clonidine; Cold Temperature; Double-Blind Method; Epinephrine; Female; Humans | 1993 |
Double-blind randomised controlled trial of lofexidine versus clonidine in the treatment of heroin withdrawal.
Topics: Adult; Circadian Rhythm; Clonidine; Dose-Response Relationship, Drug; Double-Blind Method; Female; H | 1997 |
Use of prazosin in management of hypertension in patients with chronic renal failure and in renal transplant recipients.
Topics: Adult; Aged; Antihypertensive Agents; Chlorothiazide; Clinical Trials as Topic; Clonidine; Drug Eval | 1975 |
Comparison of clonidine and lithium in the treatment of mania.
Topics: Adult; Bipolar Disorder; Clinical Trials as Topic; Clonidine; Depression; Double-Blind Method; Human | 1986 |
Clonidine versus methyldopa. A double blind cross-over study comparing side effects of clonidine and methyldopa administered together with chlorthalidone at a dosage producing the same blood pressure lowering effect.
Topics: Antihypertensive Agents; Blood Pressure; Chlorthalidone; Clinical Trials as Topic; Clonidine; Consti | 1972 |
32 other studies available for clonidine and Hypotension, Postural
| Article | Year |
|---|---|
Neurogenic orthostatic hypotension induced by tizanidine.
Topics: Adult; Clonidine; Female; Humans; Hypotension, Orthostatic; Middle Aged; Muscle Relaxants, Central; | 2020 |
Role of sympathetic responses on the hemodynamic consequences of rapid changes in posture in humans.
Topics: Adaptation, Physiological; Adolescent; Adrenergic alpha-Agonists; Adult; Blood Flow Velocity; Blood | 2010 |
Residual wires and autonomic failure treatment.
Topics: Antihypertensive Agents; Autonomic Nervous System; Autonomic Nervous System Diseases; Cholinesterase | 2006 |
Altered platelet alpha 2 adrenoreceptors in orthostatic hypotension.
Topics: Adult; Blood Platelets; Clonidine; Humans; Hypotension, Orthostatic; Kinetics; Male; Radioligand Ass | 1984 |
Effects of long-term clonidine administration on the hemodynamic and neuroendocrine postural responses of patients with dysautonomia.
Topics: Adult; Blood Pressure; Cardiac Output; Clonidine; Female; Heart Rate; Humans; Hypotension, Orthostat | 1983 |
Antihypertensive drugs: their postural hypotensive effect and their blood pressure lowering activity in conscious normotensive rats.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Captopril; Clonidine; Hydrochlorothiazide; Hypoten | 1983 |
Growth hormone response to clonidine is impaired in patients with central sympathetic degeneration.
Topics: Autonomic Nervous System Diseases; Blood Pressure; Clonidine; Growth Hormone; Humans; Hypotension, O | 1984 |
Paradoxical hypertension from clonidine.
Topics: Clonidine; Diabetic Neuropathies; Humans; Hypertension; Hypotension, Orthostatic; Male | 1984 |
Clonidine raises blood pressure in severe idiopathic orthostatic hypotension.
Topics: Aged; Blood Pressure; Clonidine; Female; Heart Rate; Humans; Hypertension; Hypotension, Orthostatic; | 1983 |
Hypertension in older patients: what drugs to use and when.
Topics: Aged; Antihypertensive Agents; Clonidine; Diuretics; Humans; Hypertension; Hypotension, Orthostatic; | 1982 |
[Effect of clofelin on central and renal hemodynamics during the orthostatic test in hypertensive patients].
Topics: Adult; Antihypertensive Agents; Clonidine; Female; Humans; Hypotension, Orthostatic; Male; Middle Ag | 1982 |
Orthostatic hypotension.
Topics: Cerebrovascular Circulation; Clonidine; Deamino Arginine Vasopressin; Dihydroergotamine; Dopamine; E | 1994 |
Exaggerated tendency to postural hypotension with isosorbiddinitrate on clonidine's background activity.
Topics: Aged; Clonidine; Drug Interactions; Female; Humans; Hypotension, Orthostatic; Isosorbide Dinitrate; | 1994 |
Abnormal suppression of arginine-vasopressin by clonidine in multiple system atrophy.
Topics: Adrenergic alpha-Agonists; Aged; Arginine Vasopressin; Blood Pressure; Catecholamines; Clonidine; Di | 1999 |
Normalization of blood pressure in a patient with severe orthostatic hypotension and supine hypertension using clonidine.
Topics: Adrenergic alpha-Agonists; Aged; Antihypertensive Agents; Blood Pressure; Clonidine; Female; Humans; | 2001 |
Comparative effects of clonidine and dihydroergotamine on venomotor tone and orthostatic tolerance in patients with severe hypoadrenergic orthostatic hypotension.
Topics: Adrenergic alpha-Agonists; Aged; Autonomic Nervous System Diseases; Blood Pressure; Clonidine; Dihyd | 2002 |
Therapeutic strategies for orthostatic intolerance: mechanisms, observations, and making patients feel better.
Topics: Adrenergic alpha-Agonists; Blood Pressure; Blood Volume; Clonidine; Dihydroergotamine; Humans; Hypot | 2002 |
[The orthostatic hypotension in patients treated with antihypertensive drugs (author's transl)].
Topics: Adrenergic beta-Antagonists; Adult; Age Factors; Antihypertensive Agents; Clonidine; Diuretics; Fema | 1977 |
Letter: Clonidine overdose.
Topics: Blood Pressure; Clonidine; Humans; Hypotension, Orthostatic; Male; Middle Aged; Pulse | 1976 |
[The practitioner and drug-induced, predominantly orthostatic hypotension].
Topics: Adrenergic Agents; Adrenergic Agonists; Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; A | 1978 |
Studies on orthostatic cardiovascular responses in anaesthetized cats.
Topics: Adrenergic alpha-Agonists; Anesthesia; Animals; Bretylium Compounds; Cats; Clonidine; Guanethidine; | 1975 |
Isolated failure of noradrenergic transmission in a case with orthostatic hypotension and hyperactivity of gastro-colic reflex.
Topics: Adult; Atropine; Autonomic Nervous System Diseases; Blood Pressure; Clonidine; Colon; Defecation; Ed | 1992 |
Pharmacological evidence of alpha 1- and alpha 2-adrenergic supersensitivity in orthostatic hypotension due to spinal cord injury: a case report.
Topics: Blood Pressure; Chronic Disease; Clonidine; Efferent Pathways; Humans; Hypotension, Orthostatic; Mal | 1991 |
Evaluation of the central and peripheral components for induction of postural hypotension by guanethidine, clonidine, dopamine2 receptor agonists and 5-hydroxytryptamine1A receptor agonists.
Topics: Animals; Blood Pressure; Bradycardia; Cats; Central Nervous System; Clonidine; Female; Guanethidine; | 1991 |
[Clinical aspects and diagnosis of klofelin poisoning].
Topics: Adolescent; Adult; Bradycardia; Clonidine; Combined Modality Therapy; Electrocardiography; Female; H | 1990 |
Effectiveness of clonidine in congenital orthostatic hypotension.
Topics: Adolescent; Adult; Blood Pressure; Clonidine; Follow-Up Studies; Humans; Hypotension, Orthostatic; M | 1990 |
[Correction of severe orthostatic hypotension with clonidine].
Topics: Aged; Clonidine; Female; Humans; Hypotension, Orthostatic | 1986 |
Isolated failure of autonomic noradrenergic neurotransmission. Evidence for impaired beta-hydroxylation of dopamine.
Topics: Adrenergic Fibers; Adult; Autonomic Nervous System Diseases; Blood Pressure; Clonidine; Dopamine; Fe | 1986 |
Decreased alpha 2-adrenergic receptors on platelet membranes from diabetic patients with autonomic neuropathy and orthostatic hypotension.
Topics: Adult; Aged; Autonomic Nervous System Diseases; Blood Platelets; Catecholamines; Clonidine; Diabetic | 1986 |
Use of alpha 2 adrenoreceptor agonists and antagonists in the functional assessment of the sympathetic nervous system.
Topics: Adult; Aged; Autonomic Nervous System Diseases; Blood Pressure; Clonidine; Female; Humans; Hypotensi | 1986 |
[General principles of antihypertensive treatment].
Topics: Antihypertensive Agents; Cardiac Output; Clonidine; Follow-Up Studies; Ganglionic Blockers; Guanethi | 1974 |
Adrenolytic and vasodilator therapy.
Topics: Adrenergic beta-Antagonists; Benzyl Compounds; Blood Circulation; Cardiac Output; Clonidine; Diazoxi | 1974 |