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clonidine and Hypoglycemia

clonidine has been researched along with Hypoglycemia in 26 studies

Clonidine: An imidazoline sympatholytic agent that stimulates ALPHA-2 ADRENERGIC RECEPTORS and central IMIDAZOLINE RECEPTORS. It is commonly used in the management of HYPERTENSION.
clonidine (amino form) : A clonidine that is 4,5-dihydro-1H-imidazol-2-amine in which one of the amino hydrogens is replaced by a 2,6-dichlorophenyl group.

Hypoglycemia: A syndrome of abnormally low BLOOD GLUCOSE level. Clinical hypoglycemia has diverse etiologies. Severe hypoglycemia eventually lead to glucose deprivation of the CENTRAL NERVOUS SYSTEM resulting in HUNGER; SWEATING; PARESTHESIA; impaired mental function; SEIZURES; COMA; and even DEATH.

Research Excerpts

ExcerptRelevanceReference
" Now, we sought to determine if we could detect a GH response to hypoglycemia (ITT: insulin tolerance test) or clonidine (CL) in these patients."9.12GH response to hypoglycemia and clonidine in the GH-releasing hormone resistance syndrome. ( Aguiar-Oliveira, MH; Almeida, JC; Britto, AV; Farias, CT; Oliveira, CR; Oliveira, JL; Parmigiani, G; Prado, CM; Salvatori, R; Serpa, MG; Vicente, TA, 2006)
"We have observed 4 cases of hypoglycemia associated with clonidine stimulation of growth hormone secretion; only one patient had growth hormone deficiency."7.71Hypoglycemia associated with clonidine testing for growth hormone deficiency. ( Banerjee, K; Daneman, D; Huang, C; Perlman, K; Sochett, E; Wherrett, D, 2001)
" We have studied the effect of oral clonidine, insulin hypoglycemia, and exercise on plasma hGH and GHRH levels in 31 healthy short-stature children."7.68Effect of oral clonidine, insulin-induced hypoglycemia and exercise on plasma GHRH levels in short-stature children. ( Gil-Ad, I; Josefsberg, Z; Laron, Z; Leibowitch, N; Wasserman, M, 1990)
"Obesity is associated with an impairment of the GH secretion elicited by all stimuli known to date, but the basic mechanism of this alteration is unknown."5.28Effect of central cholinergic neurotransmission enhancement by pyridostigmine on the growth hormone secretion elicited by clonidine, arginine, or hypoglycemia in normal and obese subjects. ( Casanueva, FF; Cordido, F; Dieguez, C, 1990)
"Clonidine induced an increase of more than 10 ng/ml in the plasma hGH levels in 10 (4 males, 6 females) of the 13 obese subjects and in all of the healthy controls, with peak levels ranging from 14."5.27Plasma growth hormone response to oral clonidine as compared to insulin hypoglycemia in obese children and adolescents. ( Bauman, B; Gil-Ad, I; Josefsberg, Z; Laron, Z; Topper, E, 1984)
" Now, we sought to determine if we could detect a GH response to hypoglycemia (ITT: insulin tolerance test) or clonidine (CL) in these patients."5.12GH response to hypoglycemia and clonidine in the GH-releasing hormone resistance syndrome. ( Aguiar-Oliveira, MH; Almeida, JC; Britto, AV; Farias, CT; Oliveira, CR; Oliveira, JL; Parmigiani, G; Prado, CM; Salvatori, R; Serpa, MG; Vicente, TA, 2006)
"We have observed 4 cases of hypoglycemia associated with clonidine stimulation of growth hormone secretion; only one patient had growth hormone deficiency."3.71Hypoglycemia associated with clonidine testing for growth hormone deficiency. ( Banerjee, K; Daneman, D; Huang, C; Perlman, K; Sochett, E; Wherrett, D, 2001)
"A gender difference in the glucagon response to insulin-induced hypoglycemia was previously demonstrated in humans."3.71Gender difference in the glucagon response to glucopenic stress in mice. ( Ahrén, B; Karlsson, S; Scheurink, AJ, 2002)
"Insulin induced hypoglycemia (< 3 mmol/l) and clonidine induced depression of noradrenergic tone were used to assess the acute effects of cortisol, human growth hormone (hGH), and norepinephrine (NE)."3.69Somatomedin C (insulin-like growth factor 1) levels decrease during acute changes of stress related hormones. Relevance for fibromyalgia. ( Baraldo, M; Bartoli, E; Ferraccioli, G; Furlanut, M; Guerra, P; Rizzi, V; Salaffi, F, 1994)
"8), we studied the GH response to physical exercise, insulin-induced hypoglycemia, arginine (ARG), clonidine, levodopa, glucagon, pyridostigmine (PD), GHRH, PD + GHRH, and ARG + GHRH."3.69Reliability of provocative tests to assess growth hormone secretory status. Study in 472 normally growing children. ( Aimaretti, G; Bartolotta, E; Bellone, J; Bellone, S; Camanni, F; Cappa, M; Dammacco, F; Ghigo, E; Loche, S, 1996)
" We have studied the effect of oral clonidine, insulin hypoglycemia, and exercise on plasma hGH and GHRH levels in 31 healthy short-stature children."3.68Effect of oral clonidine, insulin-induced hypoglycemia and exercise on plasma GHRH levels in short-stature children. ( Gil-Ad, I; Josefsberg, Z; Laron, Z; Leibowitch, N; Wasserman, M, 1990)
"We studied basal serum GH and GH responses to iv clonidine and insulin-induced hypoglycemia in a group of four young (5-7 yr old) and four older (10-14 yr old) adult male rhesus monkeys under two restraint conditions, chair adaptation and a tether and vest system, to determine what changes in GH secretion occur with aging."3.68Changes in basal and stimulated growth hormone secretion in the aging rhesus monkey: a comparison of chair restraint and tether and vest sampling. ( Barry, S; Schutzengel, RE; Styne, DM; Wheeler, MD, 1990)
"Obesity is associated with an impairment of the GH secretion elicited by all stimuli known to date, but the basic mechanism of this alteration is unknown."1.28Effect of central cholinergic neurotransmission enhancement by pyridostigmine on the growth hormone secretion elicited by clonidine, arginine, or hypoglycemia in normal and obese subjects. ( Casanueva, FF; Cordido, F; Dieguez, C, 1990)
"Clonidine induced an increase of more than 10 ng/ml in the plasma hGH levels in 10 (4 males, 6 females) of the 13 obese subjects and in all of the healthy controls, with peak levels ranging from 14."1.27Plasma growth hormone response to oral clonidine as compared to insulin hypoglycemia in obese children and adolescents. ( Bauman, B; Gil-Ad, I; Josefsberg, Z; Laron, Z; Topper, E, 1984)
"There is a debate whether the fall in plasma cortisol concentrations after the early morning dosing of clonidine represents drug effect or normal diurnal variation."1.27Effect of clonidine on plasma cortisol concentrations. ( Ellis, NF; MacGillivray, MH; Voorhess, ML, 1986)

Research

Studies (26)

TimeframeStudies, this research(%)All Research%
pre-19908 (30.77)18.7374
1990's9 (34.62)18.2507
2000's7 (26.92)29.6817
2010's1 (3.85)24.3611
2020's1 (3.85)2.80

Authors

AuthorsStudies
Richmond, E1
Rogol, AD1
Horman, T1
Fernandes, MF1
Zhou, Y1
Fuller, B1
Tigert, M1
Leri, F1
Rachmiel, M1
Johnson, T1
Daneman, D2
Salvatori, R1
Serpa, MG1
Parmigiani, G1
Britto, AV1
Oliveira, JL1
Oliveira, CR1
Prado, CM1
Farias, CT1
Almeida, JC1
Vicente, TA1
Aguiar-Oliveira, MH1
Topper, E1
Gil-Ad, I2
Bauman, B1
Josefsberg, Z2
Laron, Z2
Adler, RA1
Sokol, HW1
Keller, E1
Sorger, D1
Willgerodt, H1
Rodríguez Doreste, OL1
Valerón Martel, C1
Carrillo Domínguez, A1
Diéguez López, C1
Mendoza Betancor, B1
Christensen, NJ1
Ferraccioli, G1
Guerra, P1
Rizzi, V1
Baraldo, M1
Salaffi, F1
Furlanut, M1
Bartoli, E1
Sridhar, GR1
Jaffe, CA1
DeMott-Friberg, R1
Barkan, AL1
Ghigo, E1
Bellone, J1
Aimaretti, G1
Bellone, S1
Loche, S1
Cappa, M1
Bartolotta, E1
Dammacco, F1
Camanni, F1
Hoeck, HC1
Vestergaard, P1
Jakobsen, PE1
Falhof, J1
Laurberg, P1
Rakover, Y1
Lavi, I1
Masalah, R1
Issam, T1
Weiner, E1
Ben-Shlomo, I1
Huang, C1
Banerjee, K1
Sochett, E1
Perlman, K1
Wherrett, D1
Karlsson, S1
Scheurink, AJ1
Ahrén, B1
Lanes, R1
Díez, JJ1
Sastre, J1
Iglesias, P1
Selgas, R1
Romero, JR1
Méndez, J1
Gómez-Pan, A1
Martul, P1
Pineda, J1
Dieguez, C2
Casanueva, FF2
Leibowitch, N1
Wasserman, M1
Cordido, F1
Wheeler, MD1
Schutzengel, RE1
Barry, S1
Styne, DM1
Guthrie, GP1
Kotchen, TA1
Van Loon, GR1
Wittert, GA1
Joffe, BI1
Panz, VR1
Shires, R1
Baker, SG1
Seftel, HC1
Ellis, NF1
MacGillivray, MH1
Voorhess, ML1

Trials

2 trials available for clonidine and Hypoglycemia

ArticleYear
GH response to hypoglycemia and clonidine in the GH-releasing hormone resistance syndrome.
    Journal of endocrinological investigation, 2006, Volume: 29, Issue:9

    Topics: Adolescent; Adult; Blood Glucose; Body Height; Child; Child, Preschool; Clonidine; Dwarfism, Pituita

2006
Endogenous growth hormone (GH)-releasing hormone is required for GH responses to pharmacological stimuli.
    The Journal of clinical investigation, 1996, Feb-15, Volume: 97, Issue:4

    Topics: Adrenergic alpha-Agonists; Arginine; Cholinesterase Inhibitors; Clonidine; Female; Growth Hormone; G

1996

Other Studies

24 other studies available for clonidine and Hypoglycemia

ArticleYear
Testing for growth hormone deficiency in children.
    Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society, 2020, Volume: 50

    Topics: Adrenergic alpha-2 Receptor Agonists; Age Determination by Skeleton; Androgens; Arginine; Child; Chi

2020
An exploration of the aversive properties of 2-deoxy-D-glucose in rats.
    Psychopharmacology, 2018, Volume: 235, Issue:10

    Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-Agonists; Analysis of Variance; Animals; Beha

2018
Clonidine ingestion in children is not uneventful.
    The Journal of pediatrics, 2006, Volume: 148, Issue:6

    Topics: Child; Child, Preschool; Clonidine; Humans; Hypoglycemia; Hypotension; Sleep Stages; Unconsciousness

2006
Plasma growth hormone response to oral clonidine as compared to insulin hypoglycemia in obese children and adolescents.
    Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme, 1984, Volume: 16 Suppl 1

    Topics: Adolescent; Child; Child, Preschool; Clonidine; Female; Growth Hormone; Humans; Hypoglycemia; Insuli

1984
Studies of anterior pituitary-grafted rats: I. Abnormal prolactin response to thyrotropin releasing hormone, clonidine, insulin, and fasting.
    Life sciences, 1983, Jun-27, Volume: 32, Issue:26

    Topics: Animals; Clonidine; Fasting; Female; Hypoglycemia; Insulin; Pituitary Gland, Anterior; Prolactin; Ra

1983
Clonidine (Haemiton) as a reliable stimulus of growth hormone secretion in patients with short stature.
    Experimental and clinical endocrinology, 1983, Volume: 81, Issue:3

    Topics: Adolescent; Body Height; Child; Child, Preschool; Clonidine; Growth Hormone; Humans; Hypoglycemia

1983
[Evaluation of growth hormone stimulation tests using clonidine, glucagon, propanolol, hypoglycemia, arginine and L-dopa in 267 children of short stature].
    Revista clinica espanola, 1984, Apr-30, Volume: 173, Issue:2

    Topics: Arginine; Child; Clonidine; Dwarfism; Glucagon; Growth Hormone; Humans; Hypoglycemia; Levodopa; Prop

1984
Adrenergic mechanisms in selected diseases: arterial hypertension, duodenal ulcer, primary depressive illness, malignant tumors, and ketotic hypoglycemia.
    Metabolism: clinical and experimental, 1980, Volume: 29, Issue:11 Suppl 1

    Topics: Adult; Blood Pressure; Child; Clonidine; Depression; Duodenal Ulcer; Epinephrine; Female; Gastrins;

1980
Somatomedin C (insulin-like growth factor 1) levels decrease during acute changes of stress related hormones. Relevance for fibromyalgia.
    The Journal of rheumatology, 1994, Volume: 21, Issue:7

    Topics: Clonidine; Female; Fibromyalgia; Growth Hormone; Humans; Hydrocortisone; Hypoglycemia; Insulin; Insu

1994
Hypoglycemia due to sedation following clonidine test for growth hormone reserve.
    Clinical pediatrics, 1993, Volume: 32, Issue:11

    Topics: Child, Preschool; Clonidine; Female; Growth Hormone; Humans; Hypoglycemia; Hypopituitarism; Pituitar

1993
Reliability of provocative tests to assess growth hormone secretory status. Study in 472 normally growing children.
    The Journal of clinical endocrinology and metabolism, 1996, Volume: 81, Issue:9

    Topics: Adolescent; Arginine; Child; Child, Preschool; Clonidine; Exercise; Female; Glucagon; Growth Hormone

1996
Diagnosis of growth hormone (GH) deficiency in adults with hypothalamic-pituitary disorders: comparison of test results using pyridostigmine plus GH-releasing hormone (GHRH), clonidine plus GHRH, and insulin-induced hypoglycemia as GH secretagogues.
    The Journal of clinical endocrinology and metabolism, 2000, Volume: 85, Issue:4

    Topics: Adult; Clonidine; Female; Growth Hormone-Releasing Hormone; Human Growth Hormone; Humans; Hypoglycem

2000
Comparison between four immunoassays for growth hormone (GH) measurement as guides to clinical decisions following GH provocative tests.
    Journal of pediatric endocrinology & metabolism : JPEM, 2000, Volume: 13, Issue:6

    Topics: Adolescent; Arginine; Body Height; Child; Child, Preschool; Clonidine; Female; Human Growth Hormone;

2000
Hypoglycemia associated with clonidine testing for growth hormone deficiency.
    The Journal of pediatrics, 2001, Volume: 139, Issue:2

    Topics: Administration, Oral; Adolescent; Blood Glucose; Child, Preschool; Clonidine; Fasting; Female; Growt

2001
Gender difference in the glucagon response to glucopenic stress in mice.
    American journal of physiology. Regulatory, integrative and comparative physiology, 2002, Volume: 282, Issue:1

    Topics: Adrenal Glands; Animals; Antimetabolites; Autonomic Nervous System; Blood Glucose; Carbachol; Cholin

2002
Hypoglycemia associated with clonidine testing.
    The Journal of pediatrics, 2002, Volume: 140, Issue:5

    Topics: Child; Clonidine; Dwarfism, Pituitary; Humans; Hypoglycemia

2002
Growth hormone responses to pituitary and hypothalamic stimuli in CAPD patients treated with recombinant human erythropoietin.
    Advances in peritoneal dialysis. Conference on Peritoneal Dialysis, 1992, Volume: 8

    Topics: Adolescent; Adult; Clonidine; Erythropoietin; Female; Growth Hormone; Growth Hormone-Releasing Hormo

1992
Corticoid-induced growth hormone (GH) secretion in GH-deficient and normal children.
    The Journal of clinical endocrinology and metabolism, 1992, Volume: 75, Issue:2

    Topics: Adolescent; Child; Clonidine; Dexamethasone; Female; Growth Hormone; Growth Hormone-Releasing Hormon

1992
Effect of oral clonidine, insulin-induced hypoglycemia and exercise on plasma GHRH levels in short-stature children.
    Acta endocrinologica, 1990, Volume: 122, Issue:1

    Topics: Administration, Oral; Adolescent; Child; Clonidine; Dwarfism, Pituitary; Exercise; Female; Growth Ho

1990
Effect of central cholinergic neurotransmission enhancement by pyridostigmine on the growth hormone secretion elicited by clonidine, arginine, or hypoglycemia in normal and obese subjects.
    The Journal of clinical endocrinology and metabolism, 1990, Volume: 70, Issue:5

    Topics: Adolescent; Adult; Arginine; Child; Cholinergic Fibers; Clonidine; Drug Interactions; Female; Growth

1990
Changes in basal and stimulated growth hormone secretion in the aging rhesus monkey: a comparison of chair restraint and tether and vest sampling.
    The Journal of clinical endocrinology and metabolism, 1990, Volume: 71, Issue:6

    Topics: Aging; Animals; Clonidine; Growth Hormone; Growth Hormone-Releasing Hormone; Hydrocortisone; Hypogly

1990
Effect of transdermal clonidine on the endocrine responses to insulin-induced hypoglycemia in essential hypertension.
    Clinical pharmacology and therapeutics, 1989, Volume: 45, Issue:4

    Topics: Administration, Cutaneous; Adult; Aldosterone; Blood Glucose; Blood Pressure; Clonidine; Diabetes Co

1989
Hypoglycemic glucose counterregulation in healthy subjects pretreated with oral clonidine.
    Journal of endocrinological investigation, 1987, Volume: 10, Issue:6

    Topics: Clonidine; Diabetes Mellitus, Type 1; Humans; Hypoglycemia; Male

1987
Effect of clonidine on plasma cortisol concentrations.
    Clinical pharmacology and therapeutics, 1986, Volume: 39, Issue:6

    Topics: Administration, Oral; Adolescent; Child; Circadian Rhythm; Clonidine; Female; Humans; Hydrocortisone

1986