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clonidine and Hypercapnia

clonidine has been researched along with Hypercapnia in 9 studies

Clonidine: An imidazoline sympatholytic agent that stimulates ALPHA-2 ADRENERGIC RECEPTORS and central IMIDAZOLINE RECEPTORS. It is commonly used in the management of HYPERTENSION.
clonidine (amino form) : A clonidine that is 4,5-dihydro-1H-imidazol-2-amine in which one of the amino hydrogens is replaced by a 2,6-dichlorophenyl group.

Hypercapnia: A clinical manifestation of abnormal increase in the amount of carbon dioxide in arterial blood.

Research Excerpts

ExcerptRelevanceReference
"Hypoxia or hypercapnia elicits cardiovascular responses associated with increased plasma catecholamine concentrations, whereas clonidine, an alpha(2)- adrenergic agonist, decreases plasma catecholamine concentrations."7.69Clonidine modulation of hemodynamic and catecholamine responses associated with hypoxia or hypercapnia in dogs. ( Naito, H; Nishikawa, T, 1996)
" The aim of the current study was to determine the effects of clonidine premedication on the ventilatory response to hypercapnia during sevoflurane anesthesia using the carbon dioxide (CO(2)) steady state method."5.11Oral clonidine does not change ventilatory response to carbon dioxide in sevoflurane-anesthetized children. ( Mikawa, K; Nishina, K; Obara, H; Uesugi, T, 2004)
"Systemic dexmedetomidine (DXM) attenuates the cerebral vasodilation induced by hypercapnia and decreases the cerebral blood flow response to hypoxia."3.70Intrathecal dexmedetomidine attenuates hypercapnic but not hypoxic cerebral vasodilation in anesthetized rabbits. ( Dohi, S; Iida, H; Iida, M; Takenaka, M, 2000)
"Hypoxia or hypercapnia elicits cardiovascular responses associated with increased plasma catecholamine concentrations, whereas clonidine, an alpha(2)- adrenergic agonist, decreases plasma catecholamine concentrations."3.69Clonidine modulation of hemodynamic and catecholamine responses associated with hypoxia or hypercapnia in dogs. ( Naito, H; Nishikawa, T, 1996)
"Pretreatment with neostigmine completely prevented the clonidine-induced attenuation of the hypercapnic cerebral vasodilation attenuated by intrathecal clonidine (16% +/- 7%, 15% +/- 6%, 12% +/- 6%, and 16% +/- 8%, respectively)."1.33Intrathecal neostigmine prevents intrathecal clonidine from attenuating hypercapnic cerebral vasodilation in rabbits. ( Dohi, S; Iida, H; Iida, M; Kumazawa, M; Sumi, K; Takenaka, M; Tanahashi, S, 2005)

Research

Studies (9)

TimeframeStudies, this research(%)All Research%
pre-19901 (11.11)18.7374
1990's3 (33.33)18.2507
2000's5 (55.56)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Uchida, M1
Iida, H3
Osawa, Y1
Tanahashi, S2
Kumazawa, M2
Sumi, K2
Dohi, S3
Nishina, K1
Mikawa, K1
Uesugi, T1
Obara, H1
Takenaka, M2
Iida, M2
Hedrick, MS1
Ryan, ML1
Pizarro, J1
Bisgard, GE2
Nishikawa, T1
Naito, H1
Maekawa, T1
Cho, S1
Fukusaki, M1
Shibata, O1
Sumikawa, K1
O'Halloran, KD1
Herman, JK1
Sjöstrand, NO1
Klinge, E1

Trials

3 trials available for clonidine and Hypercapnia

ArticleYear
Clonidine attenuates the hemodynamic responses to hypercapnia during propofol anesthesia.
    Canadian journal of anaesthesia = Journal canadien d'anesthesie, 2004, Volume: 51, Issue:2

    Topics: Adult; Analgesics; Anesthetics, Intravenous; Clonidine; Drug Synergism; Hemodynamics; Humans; Hyperc

2004
Oral clonidine does not change ventilatory response to carbon dioxide in sevoflurane-anesthetized children.
    Paediatric anaesthesia, 2004, Volume: 14, Issue:12

    Topics: Administration, Oral; Adolescent; Analgesics; Analysis of Variance; Anesthetics, Inhalation; Carbon

2004
Effects of clonidine on human middle cerebral artery flow velocity and cerebrovascular CO2 response during sevoflurane anesthesia.
    Journal of neurosurgical anesthesiology, 1999, Volume: 11, Issue:3

    Topics: Adrenergic alpha-Agonists; Analysis of Variance; Anesthesia, Inhalation; Anesthetics, Inhalation; Bl

1999

Other Studies

6 other studies available for clonidine and Hypercapnia

ArticleYear
Intrathecal neostigmine prevents intrathecal clonidine from attenuating hypercapnic cerebral vasodilation in rabbits.
    Anesthesia and analgesia, 2005, Volume: 100, Issue:4

    Topics: Adrenergic alpha-Agonists; Anesthesia; Animals; Arterioles; Cerebrovascular Circulation; Cholinester

2005
Modulation of respiratory rhythm by alpha 2-adrenoceptors in awake and anesthetized goats.
    Journal of applied physiology (Bethesda, Md. : 1985), 1994, Volume: 77, Issue:2

    Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-Antagonists; Anesthesia; Animals; Benzazepine

1994
Clonidine modulation of hemodynamic and catecholamine responses associated with hypoxia or hypercapnia in dogs.
    Anesthesiology, 1996, Volume: 84, Issue:3

    Topics: Adrenergic alpha-Agonists; Animals; Catecholamines; Clonidine; Dogs; Female; Hemodynamics; Hypercapn

1996
Intrathecal dexmedetomidine attenuates hypercapnic but not hypoxic cerebral vasodilation in anesthetized rabbits.
    Anesthesiology, 2000, Volume: 92, Issue:5

    Topics: Adjuvants, Anesthesia; Administration, Topical; Adrenergic alpha-Agonists; Adrenergic alpha-Antagoni

2000
Ventilatory effects of alpha2-adrenoceptor blockade in awake goats.
    Respiration physiology, 2001, Volume: 126, Issue:1

    Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Benzazepines; Blood Pressure; Caro

2001
Changes in penile volume during some cardiovascular reflexes and reactions in rabbit.
    Acta physiologica Scandinavica, 1979, Volume: 106, Issue:3

    Topics: Animals; Arteries; Blood Pressure; Cardiovascular Physiological Phenomena; Cardiovascular System; Ch

1979