Page last updated: 2024-10-25

clonidine and Hyperactivity, Motor

clonidine has been researched along with Hyperactivity, Motor in 13 studies

Clonidine: An imidazoline sympatholytic agent that stimulates ALPHA-2 ADRENERGIC RECEPTORS and central IMIDAZOLINE RECEPTORS. It is commonly used in the management of HYPERTENSION.
clonidine (amino form) : A clonidine that is 4,5-dihydro-1H-imidazol-2-amine in which one of the amino hydrogens is replaced by a 2,6-dichlorophenyl group.

Research Excerpts

ExcerptRelevanceReference
"Clonidine was effective in reducing sleep initiation latency and night awakening, to a less degree in improving attention deficits hyperactivity, mood instability and aggressiveness in this cohort of 19 children with ASD."6.73Use of clonidine in children with autism spectrum disorders. ( Gordon, E; Kang, N; Ming, X; Wagner, GC, 2008)
"Among 42 patients converted from clonidine to another antihypertensive medication, few sympathomimetic side effects were observed if the clonidine dosage had been less than 1."5.26Central nervous system actions of clonidine in hypertension. ( Hoobler, SW; Kashima, T, 1977)
" Following repeated administration of the higher dose of IMI together with AMA, we observed an increase in clonidine-induced aggression in mice, and significant enhancement of D-amphetamine-induced locomotor hyperactivity, as well as phenylephrine-induced exploratory behavior, in rats."3.72The effect of combined treatment with imipramine and amantadine on the behavioral reactivity of central alpha1-adrenergic system in rats. ( Dziedzicka-Wasylewska, M; Faron-Górecka, A; Rogóz, Z; Solich, J, 2004)
"Clonidine was effective in reducing sleep initiation latency and night awakening, to a less degree in improving attention deficits hyperactivity, mood instability and aggressiveness in this cohort of 19 children with ASD."2.73Use of clonidine in children with autism spectrum disorders. ( Gordon, E; Kang, N; Ming, X; Wagner, GC, 2008)
"Tianeptine (TIA) is an antidepressant drug which enhances the reuptake of serotonin but, in contrast to tricyclics, shows no affinity for neurotransmitter receptors."1.31Effect of repeated treatment with tianeptine and fluoxetine on the central alpha(1)-adrenergic system. ( Dlaboga, D; Dziedzicka-Wasylewska, M; Maj, J; Rogóz, Z; Skuza, G, 2001)
"Among 42 patients converted from clonidine to another antihypertensive medication, few sympathomimetic side effects were observed if the clonidine dosage had been less than 1."1.26Central nervous system actions of clonidine in hypertension. ( Hoobler, SW; Kashima, T, 1977)

Research

Studies (13)

TimeframeStudies, this research(%)All Research%
pre-19904 (30.77)18.7374
1990's2 (15.38)18.2507
2000's7 (53.85)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Singh, GK1
Garabadu, D1
Muruganandam, AV1
Joshi, VK1
Krishnamurthy, S1
Niederhofer, H1
Staffen, W1
Mair, A1
Vanderschuren, LJ1
Beemster, P1
Schoffelmeer, AN1
Dziedzicka-Wasylewska, M2
Faron-Górecka, A1
Rogóz, Z2
Solich, J1
Ming, X1
Gordon, E1
Kang, N1
Wagner, GC1
Cools, AR1
Oosterloo, SK1
Gunning, WB1
Jevtovic-Todorovic, V1
Wozniak, DF1
Powell, S1
Nardi, A1
Olney, JW1
Vetulani, J1
Nalepa, I1
Antkiewicz-Michaluk, L1
Sansone, M1
Skuza, G1
Dlaboga, D1
Maj, J1
Alpern, HP1
Greer, CA1
Reinstein, DK1
Isaacson, RL1
Hoobler, SW1
Kashima, T1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
A Safe Ketamine-Based Therapy for Treatment Resistant Depression[NCT01179009]20 participants (Actual)Interventional2012-04-30Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Montgomery-Asberg Depression Rating Scale (MADRS) Total Score

The Montgomery-Asberg Depression Rating Scale (MADRS) is a 10-item scale that measures the severity of depression, with a higher score indicating a higher level of depression. The range of scores is 0 to 60. (NCT01179009)
Timeframe: 8 weeks

InterventionScores on a scale (Mean)
Ketamine 100-hour Infusion-9.0
Ketamine 40-minute Infusion-6.4

Reviews

1 review available for clonidine and Hyperactivity, Motor

ArticleYear
[Attention deficit disorder with hyperactivity].
    Nederlands tijdschrift voor geneeskunde, 1994, Apr-23, Volume: 138, Issue:17

    Topics: Adolescent; Adult; Attention Deficit Disorder with Hyperactivity; Behavior Therapy; Child; Child, Pr

1994

Trials

2 trials available for clonidine and Hyperactivity, Motor

ArticleYear
Lofexidine in hyperactive and impulsive children with autistic disorder.
    Journal of the American Academy of Child and Adolescent Psychiatry, 2002, Volume: 41, Issue:12

    Topics: Autistic Disorder; Child; Child, Preschool; Clonidine; Double-Blind Method; Female; Humans; Hyperkin

2002
Use of clonidine in children with autism spectrum disorders.
    Brain & development, 2008, Volume: 30, Issue:7

    Topics: Adolescent; Adrenergic alpha-Agonists; Aggression; Attention Deficit Disorder with Hyperactivity; At

2008

Other Studies

10 other studies available for clonidine and Hyperactivity, Motor

ArticleYear
Antidepressant activity of Asparagus racemosus in rodent models.
    Pharmacology, biochemistry, and behavior, 2009, Volume: 91, Issue:3

    Topics: 5-Hydroxytryptophan; Adrenergic alpha-Agonists; Aggression; Animals; Antidepressive Agents; Antioxid

2009
On the role of noradrenaline in psychostimulant-induced psychomotor activity and sensitization.
    Psychopharmacology, 2003, Volume: 169, Issue:2

    Topics: Amphetamine-Related Disorders; Animals; Central Nervous System Stimulants; Clonidine; Cocaine; Cocai

2003
The effect of combined treatment with imipramine and amantadine on the behavioral reactivity of central alpha1-adrenergic system in rats.
    Behavioural pharmacology, 2004, Volume: 15, Issue:2

    Topics: Administration, Oral; Adrenergic alpha-1 Receptor Agonists; Aggression; Amantadine; Amphetamine; Ani

2004
(3,4-Dihydroxyphenylimino)-2-imidazoline (DPI) and its action at noradrenergic and dopaminergic receptors in the nucleus accumbens of rats: mesolimbic catecholamine receptors and hyperactivity.
    Journal of neural transmission. Supplementum, 1983, Volume: 18

    Topics: Animals; Catecholamines; Clonidine; Ergonovine; Humans; Hyperkinesis; Imidazolines; Male; Nucleus Ac

1983
Clonidine potentiates the neuropathic pain-relieving action of MK-801 while preventing its neurotoxic and hyperactivity side effects.
    Brain research, 1998, Jan-19, Volume: 781, Issue:1-2

    Topics: Adrenergic alpha-Agonists; Analysis of Variance; Animals; Clonidine; Dizocilpine Maleate; Dose-Respo

1998
Opposite effect of simple tetrahydroisoquinolines on amphetamine- and morphine-stimulated locomotor activity in mice.
    Journal of neural transmission (Vienna, Austria : 1996), 2001, Volume: 108, Issue:5

    Topics: Adrenergic alpha-Agonists; Amphetamine; Animals; Binding, Competitive; Brain; Calcium Channels, L-Ty

2001
Effect of repeated treatment with tianeptine and fluoxetine on the central alpha(1)-adrenergic system.
    Neuropharmacology, 2001, Volume: 41, Issue:3

    Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Aggression; Animals; Binding, Competitive;

2001
A dopaminergic basis for the effects of amphetamine on a mouse "preadolescent hyperkinetic" model.
    Life sciences, 1977, Jul-01, Volume: 21, Issue:1

    Topics: Adolescent; Aging; Amphetamine; Animals; Apomorphine; Clonidine; Disease Models, Animal; Humans; Hyp

1977
Clonidine sensitivity in the developing rat.
    Brain research, 1977, Oct-28, Volume: 135, Issue:2

    Topics: Age Factors; Animals; Animals, Newborn; Catalepsy; Clonidine; Female; Humans; Hyperkinesis; Male; Mo

1977
Central nervous system actions of clonidine in hypertension.
    Mayo Clinic proceedings, 1977, Volume: 52, Issue:6

    Topics: Central Nervous System; Clonidine; Humans; Hyperkinesis; Hypertension; Sympathomimetics

1977