clonidine has been researched along with Hernia, Inguinal in 16 studies
Clonidine: An imidazoline sympatholytic agent that stimulates ALPHA-2 ADRENERGIC RECEPTORS and central IMIDAZOLINE RECEPTORS. It is commonly used in the management of HYPERTENSION.
clonidine (amino form) : A clonidine that is 4,5-dihydro-1H-imidazol-2-amine in which one of the amino hydrogens is replaced by a 2,6-dichlorophenyl group.
Hernia, Inguinal: An abdominal hernia with an external bulge in the GROIN region. It can be classified by the location of herniation. Indirect inguinal hernias occur through the internal inguinal ring. Direct inguinal hernias occur through defects in the ABDOMINAL WALL (transversalis fascia) in Hesselbach's triangle. The former type is commonly seen in children and young adults; the latter in adults.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Tizanidine is a centrally acting α2-agonist with muscle relaxant properties." | 6.82 | Tizanidine for the management of acute postoperative pain after inguinal hernia repair: A placebo-controlled double-blind trial. ( Akkaya, T; Caparlar, C; Kulaçoğlu, H; Mercan, U; Yazicioğlu, D, 2016) |
| "We conclude that for elective inguinal hernia repair, postoperative analgesia obtained by bupivacaine wound infiltration was not improved by the addition of clonidine 150 micrograms." | 6.68 | Does the addition of clonidine affect duration of analgesia of bupivacaine wound infiltration in inguinal hernia surgery? ( Eckersall, S; Elliott, S; Fligelstone, L; Jothilingam, S, 1997) |
| "We conducted a controlled, prospective study of clonidine in caudal anaesthesia in 60 children, aged 1-10 years, undergoing elective inguinal hernia repair." | 5.12 | Clonidine addition prolongs the duration of caudal analgesia. ( Korkmaz, F; Solak, M; Toker, K; Yildiz, TS, 2006) |
| "Forty-four children aged 1-5 years consecutively scheduled for inguinal hernia repair, hydrocele repair or orchidopexy were randomly assigned to receive a caudal injection of either S(+)-ketamine 1 mg x kg(-1) (group K) or S(+)-ketamine 0." | 5.11 | Caudal analgesia in children: S(+)-ketamine vs S(+)-ketamine plus clonidine. ( Almenrader, N; Canneti, A; Haiberger, R; Passariello, M; Pietropaoli, P; Rubeo, L, 2004) |
| "Using a prospective, randomized, observer-blinded study design, 40 patients, aged 1-7 years, who were undergoing elective surgery for inguinal hernia repair or orchidopexy, were randomly allocated to receive either a caudal block (group C: n = 20; ropivacaine 0." | 5.10 | Spinal versus peripheral effects of adjunct clonidine: comparison of the analgesic effect of a ropivacaine-clonidine mixture when administered as a caudal or ilioinguinal-iliohypogastric nerve blockade for inguinal surgery in children. ( Conio, A; De Negri, P; Eksborg, S; Ivani, G; Lönnqvist, PA, 2002) |
| "Tizanidine is a centrally acting α2-agonist with muscle relaxant properties." | 2.82 | Tizanidine for the management of acute postoperative pain after inguinal hernia repair: A placebo-controlled double-blind trial. ( Akkaya, T; Caparlar, C; Kulaçoğlu, H; Mercan, U; Yazicioğlu, D, 2016) |
| "Clonidine has the potential to significantly prolong the duration of caudal epidural anesthesia." | 2.76 | Effect of epidural clonidine on minimum local anesthetic concentration (ED50) of levobupivacaine for caudal block in children. ( Alberighi, OD; Disma, N; Frawley, G; Mameli, L; Montobbio, G; Pistorio, A; Tuo, P, 2011) |
| " We randomized 45 patients to 3 groups receiving intrathecal hyperbaric bupivacaine 6 mg combined with saline (Group B), clonidine 15 micro g (Group BC15), or clonidine 30 micro g (Group BC30); all solutions were diluted with saline to 3 mL." | 2.71 | Clonidine combined with small-dose bupivacaine during spinal anesthesia for inguinal herniorrhaphy: a randomized double-blinded study. ( Axelsson, K; Dobrydnjov, I; Gupta, A; Holmström, B; Klockhoff, H; Matthiesen, P; Thörn, SE, 2003) |
| "We conclude that for elective inguinal hernia repair, postoperative analgesia obtained by bupivacaine wound infiltration was not improved by the addition of clonidine 150 micrograms." | 2.68 | Does the addition of clonidine affect duration of analgesia of bupivacaine wound infiltration in inguinal hernia surgery? ( Eckersall, S; Elliott, S; Fligelstone, L; Jothilingam, S, 1997) |
| "Awake regional anaesthesia for inguinal hernia repair in former preterm infants is suggested to avoid life-threatening respiratory complications known to occur after general anaesthesia." | 1.31 | Apnoea in a former preterm infant after caudal bupivacaine with clonidine for inguinal herniorrhaphy. ( Fellmann, C; Gerber, AC; Weiss, M, 2002) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (12.50) | 18.2507 |
| 2000's | 12 (75.00) | 29.6817 |
| 2010's | 2 (12.50) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Yazicioğlu, D | 1 |
| Caparlar, C | 1 |
| Akkaya, T | 1 |
| Mercan, U | 1 |
| Kulaçoğlu, H | 1 |
| Rakesh, SV | 1 |
| Rajeev, S | 1 |
| Batra, YK | 1 |
| Rao, KL | 1 |
| Disma, N | 1 |
| Frawley, G | 1 |
| Mameli, L | 1 |
| Pistorio, A | 1 |
| Alberighi, OD | 1 |
| Montobbio, G | 1 |
| Tuo, P | 1 |
| Fellmann, C | 1 |
| Gerber, AC | 1 |
| Weiss, M | 1 |
| Ivani, G | 1 |
| Conio, A | 1 |
| De Negri, P | 1 |
| Eksborg, S | 1 |
| Lönnqvist, PA | 1 |
| Dobrydnjov, I | 1 |
| Axelsson, K | 1 |
| Thörn, SE | 1 |
| Matthiesen, P | 1 |
| Klockhoff, H | 1 |
| Holmström, B | 1 |
| Gupta, A | 1 |
| Hussain, AS | 1 |
| Siddiqui, MS | 1 |
| Hamdard, F | 1 |
| Mayhew, JF | 1 |
| Rochette, A | 2 |
| Raux, O | 2 |
| Troncin, R | 2 |
| Dadure, C | 2 |
| Verdier, R | 1 |
| Capdevila, X | 2 |
| Joshi, W | 1 |
| Connelly, NR | 1 |
| Freeman, K | 1 |
| Reuben, SS | 1 |
| Passariello, M | 1 |
| Almenrader, N | 1 |
| Canneti, A | 1 |
| Rubeo, L | 1 |
| Haiberger, R | 1 |
| Pietropaoli, P | 1 |
| Galante, D | 1 |
| Beaussier, M | 1 |
| Weickmans, H | 1 |
| Abdelhalim, Z | 1 |
| Lienhart, A | 1 |
| Lubrano, JF | 1 |
| Barbotte, E | 1 |
| Yildiz, TS | 1 |
| Korkmaz, F | 1 |
| Solak, M | 1 |
| Toker, K | 1 |
| Elliott, S | 1 |
| Eckersall, S | 1 |
| Fligelstone, L | 1 |
| Jothilingam, S | 1 |
| Breschan, C | 1 |
| Krumpholz, R | 1 |
| Likar, R | 1 |
| Kraschl, R | 1 |
| Schalk, HV | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Investigation of the Effectiveness of Tizanidine on Pain After Herniorrhaphy[NCT02016443] | Phase 4 | 30 participants (Actual) | Interventional | 2013-11-30 | Completed | ||
| Preemptive Single Dose Tizanidine and Ultrasound Guided Superficial Cervical Block on Pain After Thyroidectomy[NCT02725359] | Phase 4 | 60 participants (Actual) | Interventional | 2016-04-30 | Completed | ||
| ROPIVACAINE WITH CLONIDINE FOR PEDIATRIC RECTUS SHEATH BLOCKS- THE MAGIC COMBINATION? - A Double Blinded Prospective Study[NCT02439281] | 50 participants (Actual) | Interventional | 2015-05-31 | Terminated (stopped due to The patients were discharged on the day of the surgery.) | |||
| Neonatal Spinal Anesthesia: Effects of the Addition of Clonidine[NCT01075490] | Phase 4 | 120 participants (Anticipated) | Interventional | 2006-11-30 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Numeric Rating Pain Scores ( 0-10), will be obtained every 2 hours after PACU discharge up to 18 hours or until hospital discharge, whichever occurs first. The pain score of 0, means no pain, is a good outcome , and a pain score of 10 is excruciating pain, a very bad outcome. The average of these scores will be evaluated.The pain scores will not longer be documented after the numbness went away. (NCT02439281)
Timeframe: Logistic regression of the 4 th pain score assessment
| Intervention | units on a scale (Median) |
|---|---|
| Ropivacaine Group | 2 |
| Ropivacaine/ Clonidine Group | 1.5 |
The investigators hypothesize that patient postoperative anxiety scores are lower in the Ropivacaine/Clonidine group and postoperative anxiety scores decrease more in Ropivacaine /Clonidine Group, than in Ropivacaine Group. (NCT02439281)
Timeframe: 6 hours after block placement
| Intervention | units on a scale (Median) |
|---|---|
| Ropivacaine Group | 30 |
| Ropivacaine/ Clonidine Group | 29 |
The investigators expect no difference in incidence of complications (e.g. oversedation, hypotension, bradycardia episodes, etc.). (NCT02439281)
Timeframe: until study completion
| Intervention | Participants (Count of Participants) |
|---|---|
| Ropivacaine/ Clonidine Group | 1 |
| Ropivacaine Group | 1 |
The investigators hypothesize that rectus sheath injections with ropivacaine/ clonidine would result in longer duration of analgesia and decreased pain scores compared to ropivacaine alone. (NCT02439281)
Timeframe: indicated by the first request for pain medication at umbilicus site
| Intervention | minutes (Median) |
|---|---|
| Ropivacaine/ Clonidine Group | 230 |
| Ropivacaine Group | 240 |
The investigators hypothesize that rectus sheath injections with ropivacaine and clonidine result in longer duration of sensory block (paresthesia) compared to ropivacaine alone. (NCT02439281)
Timeframe: Indicated by return of normal sensation (expected average of 12 hours after block placement).
| Intervention | minutes (Median) |
|---|---|
| Ropivacaine/ Clonidine Group | 823.5 |
| Ropivacaine Group | 540 |
Total intravenous morphine equivalents mg/kg (NCT02439281)
Timeframe: 18 hours after surgery
| Intervention | mg/kg (Median) |
|---|---|
| Ropivacaine/ Clonidine Group | 0.20 |
| Ropivacaine Group | 0.22 |
The investigators hypothesize that rectus sheath injections with ropivacaine/ clonidine would result in better satisfaction with pain control. (NCT02439281)
Timeframe: Prior to hospital discharge (up to 24 hours after surgery)
| Intervention | units on a scale (Median) |
|---|---|
| Ropivacaine/ Clonidine Group | 9 |
| Ropivacaine Group | 9 |
11 trials available for clonidine and Hernia, Inguinal
| Article | Year |
|---|---|
Tizanidine for the management of acute postoperative pain after inguinal hernia repair: A placebo-controlled double-blind trial.
Topics: Acute Pain; Adult; Aged; Analgesics; Clonidine; Double-Blind Method; Female; Hernia, Inguinal; Herni | 2016 |
Tizanidine for the management of acute postoperative pain after inguinal hernia repair: A placebo-controlled double-blind trial.
Topics: Acute Pain; Adult; Aged; Analgesics; Clonidine; Double-Blind Method; Female; Hernia, Inguinal; Herni | 2016 |
Tizanidine for the management of acute postoperative pain after inguinal hernia repair: A placebo-controlled double-blind trial.
Topics: Acute Pain; Adult; Aged; Analgesics; Clonidine; Double-Blind Method; Female; Hernia, Inguinal; Herni | 2016 |
Tizanidine for the management of acute postoperative pain after inguinal hernia repair: A placebo-controlled double-blind trial.
Topics: Acute Pain; Adult; Aged; Analgesics; Clonidine; Double-Blind Method; Female; Hernia, Inguinal; Herni | 2016 |
Effect of epidural clonidine on minimum local anesthetic concentration (ED50) of levobupivacaine for caudal block in children.
Topics: Adjuvants, Anesthesia; Adrenergic alpha-Agonists; Analgesia, Epidural; Anesthesia, Caudal; Anestheti | 2011 |
Spinal versus peripheral effects of adjunct clonidine: comparison of the analgesic effect of a ropivacaine-clonidine mixture when administered as a caudal or ilioinguinal-iliohypogastric nerve blockade for inguinal surgery in children.
Topics: Amides; Analgesia; Anesthesia, Caudal; Anesthetics, Combined; Anesthetics, Local; Child; Child, Pres | 2002 |
Clonidine combined with small-dose bupivacaine during spinal anesthesia for inguinal herniorrhaphy: a randomized double-blinded study.
Topics: Adrenergic alpha-Agonists; Adult; Anesthesia, General; Anesthesia, Spinal; Anesthetics, Local; Bupiv | 2003 |
Clonidine prolongs spinal anesthesia in newborns: a prospective dose-ranging study.
Topics: Adrenergic alpha-Agonists; Anesthesia, Spinal; Anesthetics, Local; Bupivacaine; Clonidine; Dose-Resp | 2004 |
Analgesic effect of clonidine added to bupivacaine 0.125% in paediatric caudal blockade.
Topics: Adrenergic alpha-Agonists; Analgesics; Anesthesia, Caudal; Anesthetics, Local; Bupivacaine; Child, P | 2004 |
Caudal analgesia in children: S(+)-ketamine vs S(+)-ketamine plus clonidine.
Topics: Adrenergic alpha-Agonists; Analgesia; Anesthesia Recovery Period; Anesthesia, Caudal; Anesthetics, D | 2004 |
Inguinal herniorrhaphy under monitored anesthesia care with ilioinguinal-iliohypogastric block: the impact of adding clonidine to ropivacaine.
Topics: Adrenergic alpha-Agonists; Adult; Aged; Amides; Anesthetics, Local; Clonidine; Double-Blind Method; | 2005 |
Clonidine added to bupivacaine in neonatal spinal anesthesia: a prospective comparison in 124 preterm and term infants.
Topics: Adjuvants, Anesthesia; Analgesics; Anesthesia, Spinal; Anesthetics, Local; Bupivacaine; Clonidine; H | 2005 |
Clonidine added to bupivacaine in neonatal spinal anesthesia: a prospective comparison in 124 preterm and term infants.
Topics: Adjuvants, Anesthesia; Analgesics; Anesthesia, Spinal; Anesthetics, Local; Bupivacaine; Clonidine; H | 2005 |
Clonidine added to bupivacaine in neonatal spinal anesthesia: a prospective comparison in 124 preterm and term infants.
Topics: Adjuvants, Anesthesia; Analgesics; Anesthesia, Spinal; Anesthetics, Local; Bupivacaine; Clonidine; H | 2005 |
Clonidine added to bupivacaine in neonatal spinal anesthesia: a prospective comparison in 124 preterm and term infants.
Topics: Adjuvants, Anesthesia; Analgesics; Anesthesia, Spinal; Anesthetics, Local; Bupivacaine; Clonidine; H | 2005 |
Clonidine addition prolongs the duration of caudal analgesia.
Topics: Adjuvants, Anesthesia; Anesthesia, Caudal; Anesthetics, Local; Bupivacaine; Child; Child, Preschool; | 2006 |
Does the addition of clonidine affect duration of analgesia of bupivacaine wound infiltration in inguinal hernia surgery?
Topics: Adrenergic alpha-Agonists; Aged; Analgesia; Anesthetics, Local; Bupivacaine; Clonidine; Double-Blind | 1997 |
5 other studies available for clonidine and Hernia, Inguinal
| Article | Year |
|---|---|
Cephalad migration of intrathecal clonidine in an infant undergoing bilateral herniorrhaphy.
Topics: Adrenergic alpha-Agonists; Clonidine; Hernia, Inguinal; Humans; Infant; Injections, Spinal; Intraope | 2009 |
Apnoea in a former preterm infant after caudal bupivacaine with clonidine for inguinal herniorrhaphy.
Topics: Anesthesia, Caudal; Anesthetics, Combined; Apnea; Bupivacaine; Clonidine; Hernia, Inguinal; Humans; | 2002 |
Postoperative apnoea in an ex-premature infant: is it only related to clonidine?
Topics: Analgesics; Anesthesia, Caudal; Anesthesia, General; Anesthetics, Local; Apnea; Bupivacaine; Clonidi | 2003 |
Preoperative apnea in a preterm infant after caudal block with ropivacaine and clonidine.
Topics: Amides; Analgesics; Anesthesia, Caudal; Anesthetics, Local; Apnea; Bradycardia; Clonidine; Hernia, I | 2005 |
Can a dose of 2microg.kg(-1) caudal clonidine cause respiratory depression in neonates?
Topics: Adrenergic alpha-Agonists; Amides; Anesthesia, Caudal; Anesthesia, Inhalation; Anesthetics, Local; A | 1999 |