clonidine has been researched along with Heart Failure in 59 studies
Clonidine: An imidazoline sympatholytic agent that stimulates ALPHA-2 ADRENERGIC RECEPTORS and central IMIDAZOLINE RECEPTORS. It is commonly used in the management of HYPERTENSION.
clonidine (amino form) : A clonidine that is 4,5-dihydro-1H-imidazol-2-amine in which one of the amino hydrogens is replaced by a 2,6-dichlorophenyl group.
Heart Failure: A heterogeneous condition in which the heart is unable to pump out sufficient blood to meet the metabolic need of the body. Heart failure can be caused by structural defects, functional abnormalities (VENTRICULAR DYSFUNCTION), or a sudden overload beyond its capacity. Chronic heart failure is more common than acute heart failure which results from sudden insult to cardiac function, such as MYOCARDIAL INFARCTION.
| Excerpt | Relevance | Reference |
|---|---|---|
| "This study examined the effects of low doses of intravenous clonidine on regional and global sympathetic nervous system activity in heart failure." | 9.10 | Regional sympathetic effects of low-dose clonidine in heart failure. ( Aggarwal, A; Esler, MD; Kaye, DM; Lambert, G; Morris, MJ, 2003) |
| "This randomized, double-blind, placebo-controlled study examines the effects of clonidine (a centrally acting sympathoinhibitor) on ventricular arrhythmias in 35 patients with congestive heart failure (CHF) by using the 24-h ambulatory electrocardiographic recording." | 9.08 | Suppressing sympathetic activation with clonidine on ventricular arrhythmias in congestive heart failure. ( Song, YC; Zhang, YH; Zhu, J, 1998) |
| "In this double-blind, placebo-controlled crossover study, we examined the effect of transdermal clonidine (given for 5 days) on autonomic control in 14 patients with mild to moderate congestive heart failure by heart rate variability analysis." | 9.08 | Sympathetic inhibition with clonidine improves autonomic balance in congestive heart failure. ( Jun, Z; Xian-qi, Y; You-cheng, S; You-hua, Z, 1997) |
| "The authors performed a randomized, double-blind, placebo-controlled trial to assess the tolerance and effects of chronic oral clonidine administration on the clinical status, exercise tolerance, and ventricular function of 10 male patients with chronic heart failure." | 9.06 | Acute and short-term effects of clonidine in heart failure. ( Giles, TD; Plauche, W; Quiroz, A; Rice, JC; Sander, GE; Thomas, MG, 1987) |
| "The case of a 59-year-old healthy woman is described, who developed an extreme sinus bradycardia (30/min) with chest pain and acute right heart failure associated with gastrointestinal symptoms and elevation of the liver enzymes while simultaneously taking tizanidine (Sirdalud), diclofenac (Voltaren), and rofecoxib (Vioxx)." | 7.73 | [Extreme sinus bradycardia (30/min) with acute right heart failure under tizanidine (Sirdalud). Possible pharmacological interaction with rofecoxib (Vioxx)]. ( Bertoli, R; Caduff Janosa, P; Cerny, A; Kick, A; Moschovitis, G, 2005) |
| "In this patient with preoperative heart failure, clonidine was effective to treat bupivacaine induced conduction disturbances." | 7.72 | Successful resuscitation of serious bupivacaine intoxication in a patient with pre-existing heart failure. ( Allanic, L; Da Conceiçao, M; Fassassi, M; Favier, JC; Pitti, R; Steiner, T, 2003) |
| "We studied the effects of clonidine on cardiac sympathetic activity and left ventricular function in patients with congestive heart failure (CHF)." | 7.70 | Cardiac and systemic sympathetic activity in response to clonidine in human heart failure. ( Azevedo, ER; Newton, GE; Parker, JD, 1999) |
| "To determine whether alpha2-adrenergic-mediated sympathoinhibition was altered in chronic heart failure, sympathoinhibitory sensitivity was assessed using the alpha2-adrenergic agonist clonidine in 7 patients with heart failure and in 10 healthy control subjects." | 7.69 | Sympathoinhibitory response to clonidine is blunted in patients with heart failure. ( Belas, FJ; Blair, IA; He, HB; Lang, CC; Nelson, RA; Stein, CM; Wood, AJ; Wood, M, 1997) |
| "This study examined the interaction of chloroethylclonidine with alpha-adrenoceptor agonists in canine endothelium-denuded dorsal pedal artery and saphenous vein before (non-paced) and at end-stage heart failure which was induced by rapid ventricular pacing (250 bpm for no more than four weeks)." | 7.69 | Chloroethylclonidine and alpha-adrenoceptor agonist interaction in blood vessels following heart failure. ( Forster, C; Le Tran, Y, 1997) |
| " To study the influence of a specific sinus node inhibitor on myocardial function, alinidine was given to 10 patients with chronic congestive heart failure and stable sinus rhythm." | 7.68 | Hemodynamic effects of alinidine (ST 567) at rest and during exercise in patients with chronic congestive heart failure. ( Henze, E; Koenig, W; Stauch, M; Sund, M; Wanjura, D, 1990) |
| "The differential effects of the alpha-2 adrenergic agonist, clonidine, on blood pressure, renal sympathetic nerve activity (RSNA) and renal responses were investigated in conscious as well as anesthetized congestive heart failure (CHF) rats and normal control animals." | 7.68 | Effects of clonidine on renal sympathetic nerve activity, natriuresis and diuresis in chronic congestive heart failure rats. ( Carlsson, S; Feng, QP; Hedner, T; Thorén, P, 1992) |
| "Clonidine withdrawal syndrome is described in a patient with heart failure and suspected cardiogenic shock." | 7.67 | Clonidine withdrawal syndrome in a patient with heart failure. ( Donker, AJ; van der Geest, S; van Dijk, RB, 1985) |
| "The effects of intravenous (IV) clonidine (150 micrograms) on the isolated forearm venous segment of ten patients with heart failure were studied." | 7.66 | The effect of intravenous clonidine hydrochloride on the isolated forearm venous segment in heart failure. ( Eilen, SD; Giles, TD; Quiroz, AC; Sander, GE, 1983) |
| "Fourteen patients with moderately severe congestive heart failure (CHF) were given clonidine orally (0." | 7.66 | Clonidine in congestive heart failure: a vasodilator with negative inotropic effects. ( Hermiller, JB; Leier, CV; Leithe, ME; Magorien, RD; Unverferth, DV, 1983) |
| "After intravenous bolus injections of clonidine HCl (150 micrograms) to 12 patients with congestive heart failure, peak effects appeared in 5 to 20 min." | 7.66 | Short-term effects of intravenous clonidine in congestive heart failure. ( Dillenkoffer, RL; Giles, TD; Iteld, BJ; Mautner, RK; Rognoni, PA, 1981) |
| "Thus, in congestive heart failure patients who are undergoing conventional drug treatment, chronic clonidine administration exerts marked sympathoinhibitory effects without adversely affecting cardiac functions and clinical state." | 6.70 | Effects of chronic clonidine administration on sympathetic nerve traffic and baroreflex function in heart failure. ( Bertinieri, G; Grassi, G; Mancia, G; Pierini, A; Seravalle, G; Turri, C, 2001) |
| " ITC was delivered locally via catheter to the T2-T4 spinal segments and was dosed to reduce heart rate (HR) by >20% to 25%." | 5.33 | Intrathecal clonidine reduces the incidence of ischemia-provoked ventricular arrhythmias in a canine postinfarction heart failure model. ( Groh, WJ; Hildebrand, KR; Issa, ZF; Miller, JM; Rosenberger, J; Ujhelyi, MR; Zhou, X; Zipes, DP, 2005) |
| "In patients with congestive heart failure, abnormal heart rate variability is a predictor of total mortality and sudden cardiac death." | 5.30 | Effect of clonidine on heart rate variability in congestive heart failure. ( Castellanos, A; Chakko, S; de Marchena, E; Diaz, P; Girgis, I; Jara, C; Myerburg, RJ, 1998) |
| "This study examined the effects of low doses of intravenous clonidine on regional and global sympathetic nervous system activity in heart failure." | 5.10 | Regional sympathetic effects of low-dose clonidine in heart failure. ( Aggarwal, A; Esler, MD; Kaye, DM; Lambert, G; Morris, MJ, 2003) |
| "In this double-blind, placebo-controlled crossover study, we examined the effect of transdermal clonidine (given for 5 days) on autonomic control in 14 patients with mild to moderate congestive heart failure by heart rate variability analysis." | 5.08 | Sympathetic inhibition with clonidine improves autonomic balance in congestive heart failure. ( Jun, Z; Xian-qi, Y; You-cheng, S; You-hua, Z, 1997) |
| "This randomized, double-blind, placebo-controlled study examines the effects of clonidine (a centrally acting sympathoinhibitor) on ventricular arrhythmias in 35 patients with congestive heart failure (CHF) by using the 24-h ambulatory electrocardiographic recording." | 5.08 | Suppressing sympathetic activation with clonidine on ventricular arrhythmias in congestive heart failure. ( Song, YC; Zhang, YH; Zhu, J, 1998) |
| "The authors performed a randomized, double-blind, placebo-controlled trial to assess the tolerance and effects of chronic oral clonidine administration on the clinical status, exercise tolerance, and ventricular function of 10 male patients with chronic heart failure." | 5.06 | Acute and short-term effects of clonidine in heart failure. ( Giles, TD; Plauche, W; Quiroz, A; Rice, JC; Sander, GE; Thomas, MG, 1987) |
| "The effects of prazosin, clonidine, and indoramin on central and regional hemodynamic parameters and left ventricular performance were analyzed in a congestive heart failure population to compare the pharmacodynamic responses to different levels of alpha-adrenergic interruption in this condition." | 5.06 | Hemodynamic responses to different levels of alpha-adrenergic interruption in congestive heart failure. ( Good, AP; Leier, CV; Unverferth, DV, 1988) |
| " It has also been used intravenously in phaeochromocytoma, tetanus, clonidine withdrawal, and as an adjunct to halothane to produce hypotensive anaesthesia." | 4.76 | Combined alpha- and beta-receptor inhibition in the treatment of hypertension. ( Prichard, BN, 1984) |
| "The case of a 59-year-old healthy woman is described, who developed an extreme sinus bradycardia (30/min) with chest pain and acute right heart failure associated with gastrointestinal symptoms and elevation of the liver enzymes while simultaneously taking tizanidine (Sirdalud), diclofenac (Voltaren), and rofecoxib (Vioxx)." | 3.73 | [Extreme sinus bradycardia (30/min) with acute right heart failure under tizanidine (Sirdalud). Possible pharmacological interaction with rofecoxib (Vioxx)]. ( Bertoli, R; Caduff Janosa, P; Cerny, A; Kick, A; Moschovitis, G, 2005) |
| "In this patient with preoperative heart failure, clonidine was effective to treat bupivacaine induced conduction disturbances." | 3.72 | Successful resuscitation of serious bupivacaine intoxication in a patient with pre-existing heart failure. ( Allanic, L; Da Conceiçao, M; Fassassi, M; Favier, JC; Pitti, R; Steiner, T, 2003) |
| " Clonidine, an imidazoline and adrenergic agonist with high selectivity for the alpha-2 adrenoceptor, has been shown to reduce generalized sympathetic activity in heart failure after parenteral administration." | 3.71 | Evidence for functional presynaptic alpha-2 adrenoceptors and their down-regulation in human heart failure. ( Aggarwal, A; Esler, MD; Kaye, DM; Socratous, F, 2001) |
| "Previous short-term studies demonstrated that treatment with clonidine produced significant hemodynamic improvement in patients with congestive heart failure (CHF)." | 3.70 | Chronic sympathetic suppression in the treatment of chronic congestive heart failure. ( Argirakis, S; Gavras, H; Gavras, I; Handanis, S; Katsaros, C; Manolis, AJ; Olympios, C; Sifaki, M; Smirnioudis, N, 1998) |
| "We studied the effects of clonidine on cardiac sympathetic activity and left ventricular function in patients with congestive heart failure (CHF)." | 3.70 | Cardiac and systemic sympathetic activity in response to clonidine in human heart failure. ( Azevedo, ER; Newton, GE; Parker, JD, 1999) |
| "This study examined the interaction of chloroethylclonidine with alpha-adrenoceptor agonists in canine endothelium-denuded dorsal pedal artery and saphenous vein before (non-paced) and at end-stage heart failure which was induced by rapid ventricular pacing (250 bpm for no more than four weeks)." | 3.69 | Chloroethylclonidine and alpha-adrenoceptor agonist interaction in blood vessels following heart failure. ( Forster, C; Le Tran, Y, 1997) |
| "To determine whether alpha2-adrenergic-mediated sympathoinhibition was altered in chronic heart failure, sympathoinhibitory sensitivity was assessed using the alpha2-adrenergic agonist clonidine in 7 patients with heart failure and in 10 healthy control subjects." | 3.69 | Sympathoinhibitory response to clonidine is blunted in patients with heart failure. ( Belas, FJ; Blair, IA; He, HB; Lang, CC; Nelson, RA; Stein, CM; Wood, AJ; Wood, M, 1997) |
| "The differential effects of the alpha-2 adrenergic agonist, clonidine, on blood pressure, renal sympathetic nerve activity (RSNA) and renal responses were investigated in conscious as well as anesthetized congestive heart failure (CHF) rats and normal control animals." | 3.68 | Effects of clonidine on renal sympathetic nerve activity, natriuresis and diuresis in chronic congestive heart failure rats. ( Carlsson, S; Feng, QP; Hedner, T; Thorén, P, 1992) |
| " To study the influence of a specific sinus node inhibitor on myocardial function, alinidine was given to 10 patients with chronic congestive heart failure and stable sinus rhythm." | 3.68 | Hemodynamic effects of alinidine (ST 567) at rest and during exercise in patients with chronic congestive heart failure. ( Henze, E; Koenig, W; Stauch, M; Sund, M; Wanjura, D, 1990) |
| " On this basis, functional and therapeutical regimen of regression of cardiac hypertrophy (prazosin, clonidine, nifedipine) are analyzed in concentric as well as in excentric hypertrophy in patients with arterial hypertension." | 3.67 | [Progression and regression of heart hypertrophy in arterial hypertension: pathophysiology and clinical aspects]. ( Strauer, BE, 1985) |
| "Clonidine withdrawal syndrome is described in a patient with heart failure and suspected cardiogenic shock." | 3.67 | Clonidine withdrawal syndrome in a patient with heart failure. ( Donker, AJ; van der Geest, S; van Dijk, RB, 1985) |
| "After intravenous bolus injections of clonidine HCl (150 micrograms) to 12 patients with congestive heart failure, peak effects appeared in 5 to 20 min." | 3.66 | Short-term effects of intravenous clonidine in congestive heart failure. ( Dillenkoffer, RL; Giles, TD; Iteld, BJ; Mautner, RK; Rognoni, PA, 1981) |
| "Fourteen patients with moderately severe congestive heart failure (CHF) were given clonidine orally (0." | 3.66 | Clonidine in congestive heart failure: a vasodilator with negative inotropic effects. ( Hermiller, JB; Leier, CV; Leithe, ME; Magorien, RD; Unverferth, DV, 1983) |
| "The effects of intravenous (IV) clonidine (150 micrograms) on the isolated forearm venous segment of ten patients with heart failure were studied." | 3.66 | The effect of intravenous clonidine hydrochloride on the isolated forearm venous segment in heart failure. ( Eilen, SD; Giles, TD; Quiroz, AC; Sander, GE, 1983) |
| "Thus, in congestive heart failure patients who are undergoing conventional drug treatment, chronic clonidine administration exerts marked sympathoinhibitory effects without adversely affecting cardiac functions and clinical state." | 2.70 | Effects of chronic clonidine administration on sympathetic nerve traffic and baroreflex function in heart failure. ( Bertinieri, G; Grassi, G; Mancia, G; Pierini, A; Seravalle, G; Turri, C, 2001) |
| " In this situation, alpha 2-agonists reduce sympathetic activity and improve hemodynamic parameters of cardiac function; both acute and chronic administration of alpha 2-AR have been demonstrated to reduce serum catecholamine levels, heart rate, and arterial blood pressure, and to improve exercise performance." | 2.66 | Alpha-adrenergic mechanisms in the pathophysiology of left ventricular heart failure--an analysis of their role in systolic and diastolic dysfunction. ( Giles, TD; Quiroz, AC; Sander, GE; Thomas, MG, 1986) |
| "Congestive heart failure is a complex clinical syndrome characterized by striking abnormalities of the autonomic nervous system." | 2.37 | The autonomic nervous system in congestive heart failure. ( Cohn, JN; Francis, GS, 1986) |
| " ITC was delivered locally via catheter to the T2-T4 spinal segments and was dosed to reduce heart rate (HR) by >20% to 25%." | 1.33 | Intrathecal clonidine reduces the incidence of ischemia-provoked ventricular arrhythmias in a canine postinfarction heart failure model. ( Groh, WJ; Hildebrand, KR; Issa, ZF; Miller, JM; Rosenberger, J; Ujhelyi, MR; Zhou, X; Zipes, DP, 2005) |
| "Clonidine is a valuable adjunct for conscious sedation and can be used safely for sympathicolysis, even in patients with aortic stenosis." | 1.31 | Difficult airway management in a patient with severe aortic stenosis, coronary artery disease, and heart failure. ( Kulka, PJ; Tryba, M; Zenz, M, 2002) |
| "In patients with congestive heart failure, abnormal heart rate variability is a predictor of total mortality and sudden cardiac death." | 1.30 | Effect of clonidine on heart rate variability in congestive heart failure. ( Castellanos, A; Chakko, S; de Marchena, E; Diaz, P; Girgis, I; Jara, C; Myerburg, RJ, 1998) |
| "Heart failure was induced in Sprague-Dawley rats by coronary artery ligation." | 1.30 | Decreased responsiveness of vascular postjunctional alpha1-, alpha2-adrenoceptors and neuropeptide Y1 receptors in rats with heart failure. ( Edvinsson, L; Feng, Q; Hedner, T; Lu, X; Sun, X, 1999) |
| " The dose-response curve in CHF was shifted to the right with a pD2 value of 5." | 1.29 | Vascular alpha-2 adrenoceptor function is decreased in rats with congestive heart failure. ( Bergdahl, A; Edvinsson, L; Feng, QP; Hedner, T; Lu, XR; Sun, XY, 1996) |
| "Patients with chronic congestive heart failure (CHF) are known to have elevated plasma concentrations of norepinephrine." | 1.27 | Platelet alpha 2 adrenoreceptors in chronic congestive heart failure. ( Smith, CB; Tobes, M; Weiss, RJ; Wertz, CE, 1983) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 26 (44.07) | 18.7374 |
| 1990's | 20 (33.90) | 18.2507 |
| 2000's | 11 (18.64) | 29.6817 |
| 2010's | 2 (3.39) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Middlekauff, HR | 1 |
| Verity, MA | 1 |
| Horwich, TB | 1 |
| Fonarow, GC | 1 |
| Hamilton, MA | 1 |
| Shieh, P | 1 |
| Moorman, AJ | 1 |
| Stratton, JR | 1 |
| Levy, WC | 1 |
| Lechin, F | 1 |
| Lechin, M | 1 |
| van der Dijs, B | 1 |
| Favier, JC | 1 |
| Da Conceiçao, M | 1 |
| Fassassi, M | 1 |
| Allanic, L | 1 |
| Steiner, T | 1 |
| Pitti, R | 1 |
| Aggarwal, A | 2 |
| Esler, MD | 2 |
| Morris, MJ | 1 |
| Lambert, G | 1 |
| Kaye, DM | 2 |
| Detsky, ME | 1 |
| Azevedo, ER | 2 |
| Parker, JD | 2 |
| Kick, A | 1 |
| Bertoli, R | 1 |
| Moschovitis, G | 1 |
| Caduff Janosa, P | 1 |
| Cerny, A | 1 |
| Issa, ZF | 1 |
| Ujhelyi, MR | 1 |
| Hildebrand, KR | 1 |
| Zhou, X | 1 |
| Rosenberger, J | 1 |
| Groh, WJ | 1 |
| Miller, JM | 1 |
| Zipes, DP | 1 |
| Houston, MC | 1 |
| Koller, H | 1 |
| Prager, H | 1 |
| Prichard, BN | 1 |
| Opie, LH | 1 |
| Weiss, RJ | 1 |
| Tobes, M | 1 |
| Wertz, CE | 1 |
| Smith, CB | 1 |
| Hayduk, K | 1 |
| Brandt, D | 2 |
| Akhmedkhanov, SSh | 2 |
| Pomerantsev, VP | 1 |
| Vasiuk, IuA | 2 |
| Quiroz, AC | 2 |
| Eilen, SD | 1 |
| Sander, GE | 3 |
| Giles, TD | 5 |
| Hermiller, JB | 1 |
| Magorien, RD | 2 |
| Leithe, ME | 1 |
| Unverferth, DV | 3 |
| Leier, CV | 3 |
| Iteld, BJ | 1 |
| Mautner, RK | 1 |
| Rognoni, PA | 1 |
| Dillenkoffer, RL | 1 |
| Manolis, AJ | 3 |
| Olympios, C | 3 |
| Sifaki, M | 3 |
| Handanis, S | 3 |
| Bresnahan, M | 2 |
| Gavras, I | 3 |
| Gavras, H | 3 |
| Sacchetti, A | 1 |
| McCabe, J | 1 |
| Torres, M | 1 |
| Harris, RL | 1 |
| Rabinovitch, MA | 1 |
| Rose, CP | 1 |
| Schwab, AJ | 1 |
| Fitchett, DH | 1 |
| Honos, GN | 1 |
| Stewart, JA | 1 |
| Chen, LF | 1 |
| Castilla, EP | 1 |
| Gomez, AA | 1 |
| Abrahamowicz, M | 1 |
| Feng, QP | 4 |
| Bergdahl, A | 1 |
| Lu, XR | 1 |
| Sun, XY | 1 |
| Edvinsson, L | 2 |
| Hedner, T | 5 |
| Cokkinos, D | 1 |
| Nishikawa, T | 1 |
| You-hua, Z | 1 |
| You-cheng, S | 1 |
| Jun, Z | 1 |
| Xian-qi, Y | 1 |
| Lang, CC | 1 |
| Stein, CM | 1 |
| Nelson, RA | 1 |
| He, HB | 1 |
| Belas, FJ | 1 |
| Blair, IA | 1 |
| Wood, M | 1 |
| Wood, AJ | 1 |
| Le Tran, Y | 1 |
| Forster, C | 1 |
| Girgis, I | 1 |
| Chakko, S | 1 |
| de Marchena, E | 1 |
| Jara, C | 1 |
| Diaz, P | 1 |
| Castellanos, A | 1 |
| Myerburg, RJ | 1 |
| Zhang, YH | 1 |
| Zhu, J | 1 |
| Song, YC | 1 |
| Smirnioudis, N | 1 |
| Argirakis, S | 1 |
| Katsaros, C | 1 |
| Newton, GE | 1 |
| Feng, Q | 1 |
| Sun, X | 1 |
| Lu, X | 1 |
| Coats, AJ | 1 |
| Zhang, Y | 1 |
| Cheng, Z | 1 |
| Socratous, F | 1 |
| Grassi, G | 1 |
| Turri, C | 1 |
| Seravalle, G | 1 |
| Bertinieri, G | 1 |
| Pierini, A | 1 |
| Mancia, G | 1 |
| Kulka, PJ | 1 |
| Tryba, M | 1 |
| Zenz, M | 1 |
| Sterz, H | 1 |
| Enenkel, W | 1 |
| Ban, M | 1 |
| Matsuno, T | 1 |
| Ogawa, K | 1 |
| Satake, T | 1 |
| Carlsson, S | 2 |
| Thorén, P | 2 |
| Hedner, J | 1 |
| Pettersson, A | 1 |
| Manmontri, A | 1 |
| MacLeod, SM | 1 |
| Koenig, W | 1 |
| Stauch, M | 1 |
| Sund, M | 1 |
| Wanjura, D | 1 |
| Henze, E | 1 |
| Motz, W | 1 |
| Strauer, BE | 2 |
| Urbaszek, W | 1 |
| Graf, B | 1 |
| Francis, GS | 1 |
| Cohn, JN | 1 |
| Thomas, MG | 2 |
| Good, AP | 1 |
| Yin, HQ | 1 |
| Chen, DG | 1 |
| Shen, BR | 1 |
| Wang, RM | 1 |
| Liu, YL | 1 |
| Quiroz, A | 1 |
| Rice, JC | 1 |
| Plauche, W | 1 |
| Ren, JH | 1 |
| van der Geest, S | 1 |
| van Dijk, RB | 1 |
| Donker, AJ | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Clonidine and the Skeletal Myopathy of Heart Failure[NCT00858845] | Phase 4 | 11 participants (Actual) | Interventional | 2008-05-31 | Completed | ||
| Anxiety-mediated Impairments in Large Elastic Artery Function and the Autonomic Nervous System[NCT03109795] | Phase 4 | 30 participants (Actual) | Interventional | 2017-04-10 | Terminated (stopped due to Funding ended) | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
(NCT00858845)
Timeframe: Baseline, 3 months
| Intervention | micromole/min/wet weight (Mean) |
|---|---|
| Clonidine Patch | -0.3 |
| Placebo | 0.07 |
Muscle sympathetic nerve activity was measured as bursts sympathetic nerve activity per minute. (NCT00858845)
Timeframe: Baseline, 3 months
| Intervention | bursts/min (Mean) |
|---|---|
| Clonidine Patch | -4.3 |
| Placebo | 4.4 |
Fibers were typed as I or II according to presence of myosin heavy chain. (NCT00858845)
Timeframe: Baseline, 3 months
| Intervention | percentage of fibers (Mean) |
|---|---|
| Clonidine Patch | -4.6 |
| Placebo | -5.6 |
8 reviews available for clonidine and Heart Failure
| Article | Year |
|---|---|
Abrupt cessation of treatment in hypertension: consideration of clinical features, mechanisms, prevention and management of the discontinuation syndrome.
Topics: Acute Disease; Adrenergic beta-Antagonists; Arrhythmias, Cardiac; Bethanidine; Blood Pressure; Cloni | 1981 |
Combined alpha- and beta-receptor inhibition in the treatment of hypertension.
Topics: Administration, Oral; Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Anesthesia; Antihyp | 1984 |
[Therapy of hypertensive crisis].
Topics: Acute Disease; Bed Rest; Cardiac Glycosides; Clonidine; Diazoxide; Dihydralazine; Diuretics; Heart F | 1980 |
[Preoperative evaluation of patients with heart dysfunction and preanesthetic medication].
Topics: Adrenergic alpha-Agonists; Anesthesia, General; Clonidine; Coronary Disease; Heart Failure; Heart Fu | 1996 |
[New aspects in the treatment of acute cardiac insufficiency].
Topics: Adrenergic beta-Antagonists; Clonidine; Diazoxide; Digitalis Glycosides; Diuretics; Droperidol; Fent | 1978 |
[Cardiac therapy in the old patient].
Topics: Adrenergic beta-Antagonists; Aged; Angina Pectoris; Body Water; Calcium; Clonidine; Digitalis Glycos | 1979 |
Centrally acting sympatholytic agents in the treatment of congestive heart failure. A review of the literature.
Topics: Bromocriptine; Clinical Trials as Topic; Clonidine; Guanabenz; Heart Failure; Humans; Methyldopa; Sy | 1990 |
The autonomic nervous system in congestive heart failure.
Topics: Adrenergic beta-Antagonists; Alprazolam; Animals; Autonomic Nervous System; Benzodiazepines; Blood V | 1986 |
11 trials available for clonidine and Heart Failure
| Article | Year |
|---|---|
Intact skeletal muscle mitochondrial enzyme activity but diminished exercise capacity in advanced heart failure patients on optimal medical and device therapy.
Topics: Biopsy; Case-Control Studies; Clonidine; Double-Blind Method; Exercise Tolerance; Female; Heart Fail | 2013 |
Clonidine therapy in patients with heart failure improves exercise efficiency, functional class and symptoms.
Topics: Antihypertensive Agents; Clonidine; Double-Blind Method; Exercise; Exercise Test; Heart Failure; Hum | 2011 |
Regional sympathetic effects of low-dose clonidine in heart failure.
Topics: Aged; Brain; Clonidine; Dose-Response Relationship, Drug; Heart; Heart Failure; Hemodynamics; Humans | 2003 |
Suppressing sympathetic activation in congestive heart failure. A new therapeutic strategy.
Topics: Administration, Oral; Adult; Aged; Clonidine; Female; Heart Failure; Hemodynamics; Humans; Male; Mid | 1995 |
Combined sympathetic suppression and angiotensin-converting enzyme inhibition in congestive heart failure.
Topics: Angiotensin-Converting Enzyme Inhibitors; Captopril; Clonidine; Drug Therapy, Combination; Female; H | 1997 |
Sympathetic inhibition with clonidine improves autonomic balance in congestive heart failure.
Topics: Administration, Cutaneous; Adrenergic Agonists; Adult; Aged; Autonomic Nervous System; Clonidine; Cr | 1997 |
Suppressing sympathetic activation with clonidine on ventricular arrhythmias in congestive heart failure.
Topics: Adult; Aged; Cardiovascular Physiological Phenomena; Chi-Square Distribution; Clonidine; Double-Blin | 1998 |
Effects of chronic clonidine administration on sympathetic nerve traffic and baroreflex function in heart failure.
Topics: Baroreflex; Blood Pressure; Clonidine; Double-Blind Method; Female; Heart Failure; Heart Rate; Human | 2001 |
Alpha-adrenergic mechanisms in the pathophysiology of left ventricular heart failure--an analysis of their role in systolic and diastolic dysfunction.
Topics: Adrenergic alpha-Antagonists; Autonomic Nervous System; Central Nervous System; Clinical Trials as T | 1986 |
Hemodynamic responses to different levels of alpha-adrenergic interruption in congestive heart failure.
Topics: Adrenergic alpha-Antagonists; Clonidine; Extremities; Female; Heart Failure; Hemodynamics; Humans; I | 1988 |
Acute and short-term effects of clonidine in heart failure.
Topics: Administration, Oral; Adult; Aged; Blood Pressure; Chronic Disease; Clinical Trials as Topic; Clonid | 1987 |
40 other studies available for clonidine and Heart Failure
| Article | Year |
|---|---|
Plasma catecholamines and chronic congestive heart failure.
Topics: Adrenal Glands; Catecholamines; Chronic Disease; Clonidine; Diagnostic Techniques, Cardiovascular; D | 2002 |
Successful resuscitation of serious bupivacaine intoxication in a patient with pre-existing heart failure.
Topics: Adrenergic alpha-Agonists; Adrenergic beta-Agonists; Anesthetics, Local; Bupivacaine; Clonidine; Dob | 2003 |
Left ventricular isovolumic relaxation is a predictor of left ventricular end-diastolic pressure.
Topics: Cardiac Catheterization; Clonidine; Diastole; Female; Heart Failure; Hemodynamics; Humans; Male; Mid | 2003 |
[Extreme sinus bradycardia (30/min) with acute right heart failure under tizanidine (Sirdalud). Possible pharmacological interaction with rofecoxib (Vioxx)].
Topics: Acute Disease; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Bradycardia; Clonidine; Cyclooxy | 2005 |
Intrathecal clonidine reduces the incidence of ischemia-provoked ventricular arrhythmias in a canine postinfarction heart failure model.
Topics: Adrenergic alpha-Agonists; Animals; Blood Pressure; Clonidine; Disease Models, Animal; Dogs; Electro | 2005 |
[The use of vasodilator agents in the therapy of chronic cardiac insufficiency].
Topics: Adrenergic alpha-Antagonists; Calcium Channel Blockers; Captopril; Clonidine; Diuretics; Heart Failu | 1982 |
Principles of therapy for congestive heart failure.
Topics: Calcium; Calcium Channel Blockers; Calmodulin; Cardiotonic Agents; Clonidine; Cyclic AMP; Cytosol; D | 1983 |
Platelet alpha 2 adrenoreceptors in chronic congestive heart failure.
Topics: Adult; Aged; Blood Platelets; Clonidine; Dopamine; Epinephrine; Female; Heart Failure; Humans; In Vi | 1983 |
[Clonidine: new aspects of a known principle].
Topics: Cardiovascular Diseases; Clonidine; Heart Failure; Humans; Hypertension | 1983 |
[The hypertensive crisis].
Topics: Acute Disease; Calcium Channel Blockers; Clonidine; Coronary Disease; Diazoxide; Dihydralazine; Dilt | 1984 |
[Effect of clophelin on the hemodynamics of patients with circulatory insufficiency].
Topics: Adult; Aged; Blood Pressure; Cardiac Output; Clonidine; Heart Failure; Hemodynamics; Humans; Middle | 1984 |
The effect of intravenous clonidine hydrochloride on the isolated forearm venous segment in heart failure.
Topics: Adult; Aged; Clonidine; Forearm; Heart Failure; Humans; Middle Aged; Pulse; Vascular Resistance; Ven | 1983 |
Clonidine in congestive heart failure: a vasodilator with negative inotropic effects.
Topics: Adult; Aged; Blood Pressure; Cardiac Output; Clonidine; Depression, Chemical; Heart Failure; Heart R | 1983 |
Short-term effects of intravenous clonidine in congestive heart failure.
Topics: Adult; Aged; Blood Pressure; Cardiac Output; Clonidine; Female; Heart Failure; Heart Rate; Humans; I | 1981 |
ED management of acute congestive heart failure in renal dialysis patients.
Topics: Acute Disease; Administration, Cutaneous; Administration, Oral; Administration, Sublingual; Captopri | 1993 |
A method of dynamic analysis of iodine-123-metaiodobenzylguanidine scintigrams in cardiac mechanical overload hypertrophy and failure.
Topics: 3-Iodobenzylguanidine; Clonidine; Female; Heart; Heart Failure; Heart Transplantation; Humans; Hyper | 1993 |
Clonidine and heart failure.
Topics: Clonidine; Heart Failure; Humans; Sympatholytics | 1996 |
Vascular alpha-2 adrenoceptor function is decreased in rats with congestive heart failure.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Azepines; Clonidine; Dose-Response | 1996 |
Sympathoinhibitory response to clonidine is blunted in patients with heart failure.
Topics: Adrenergic alpha-Agonists; Aged; Clonidine; Heart Failure; Hemodynamics; Humans; Kinetics; Neural In | 1997 |
Chloroethylclonidine and alpha-adrenoceptor agonist interaction in blood vessels following heart failure.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Arteries; Clonidine; Dogs; Dose-Re | 1997 |
Effect of clonidine on heart rate variability in congestive heart failure.
Topics: Adrenergic alpha-Agonists; Blood Pressure; Chronic Disease; Clonidine; Death, Sudden, Cardiac; Elect | 1998 |
Chronic sympathetic suppression in the treatment of chronic congestive heart failure.
Topics: Administration, Oral; Catecholamines; Chronic Disease; Clonidine; Echocardiography; Electrocardiogra | 1998 |
Cardiac and systemic sympathetic activity in response to clonidine in human heart failure.
Topics: Adrenergic alpha-Agonists; Cardiomyopathy, Dilated; Clonidine; Coronary Circulation; Dose-Response R | 1999 |
Decreased responsiveness of vascular postjunctional alpha1-, alpha2-adrenoceptors and neuropeptide Y1 receptors in rats with heart failure.
Topics: Adrenergic alpha-Agonists; Animals; Atrial Natriuretic Factor; Autonomic Fibers, Preganglionic; Azep | 1999 |
Beta-blockers - again, a lesson to us all, especially the research funding community.
Topics: Adrenergic beta-Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animals; Clinical Trials as T | 2000 |
Sympathetic inhibition with clonidine prolongs survival in experimental chronic heart failure.
Topics: Animals; Blood Pressure; Chronic Disease; Clonidine; Disease Models, Animal; Heart Failure; Heart Ra | 2000 |
Evidence for functional presynaptic alpha-2 adrenoceptors and their down-regulation in human heart failure.
Topics: Aged; Clonidine; Down-Regulation; Female; Heart Failure; Hemodynamics; Humans; Male; Middle Aged; No | 2001 |
Difficult airway management in a patient with severe aortic stenosis, coronary artery disease, and heart failure.
Topics: Aortic Valve Stenosis; Clonidine; Conscious Sedation; Coronary Disease; Heart Failure; Hemodynamics; | 2002 |
Plasma norepinephrine and dopamine-beta-hydroxylase activity in chronic renal failure.
Topics: Adolescent; Adult; Aged; Blood Pressure; Clonidine; Dopamine beta-Hydroxylase; Epinephrine; Heart Fa | 1979 |
Effects of clonidine on renal sympathetic nerve activity, natriuresis and diuresis in chronic congestive heart failure rats.
Topics: Animals; Atrial Natriuretic Factor; Chronic Disease; Clonidine; Diuresis; Epinephrine; Heart Failure | 1992 |
Blunted renal response to atrial natriuretic peptide in congestive heart failure rats is reversed by the alpha 2-adrenergic agonist clonidine.
Topics: Animals; Atrial Natriuretic Factor; Blood Pressure; Clonidine; Heart Failure; Heart Rate; Kidney; Ma | 1990 |
Clonidine influences renal sympathetic nerve activity and renal function in experimental heart failure.
Topics: Animals; Blood Pressure; Clonidine; Epinephrine; Heart Failure; Kidney; Norepinephrine; Rats; Rats, | 1991 |
Hemodynamic effects of alinidine (ST 567) at rest and during exercise in patients with chronic congestive heart failure.
Topics: Aged; Anti-Arrhythmia Agents; Blood Pressure; Chronic Disease; Clonidine; Exercise; Female; Heart Fa | 1990 |
[What is safe in the therapy of hypertensive heart disease?].
Topics: Adrenergic beta-Antagonists; Aged; Angina Pectoris; Angiotensin-Converting Enzyme Inhibitors; Animal | 1985 |
[Therapy of chronic heart failure with vasodilators].
Topics: Adrenergic beta-Agonists; Angiotensin-Converting Enzyme Inhibitors; Calcium Channel Blockers; Captop | 1986 |
[Progression and regression of heart hypertrophy in arterial hypertension: pathophysiology and clinical aspects].
Topics: Blood Pressure; Cardiac Volume; Cardiomegaly; Cardiomyopathy, Hypertrophic; Clonidine; Coronary Circ | 1985 |
[Use of klofenil in heart failure].
Topics: Clonidine; Drug Evaluation; Heart Failure; Heart Function Tests; Hemodynamics; Humans; Injections, I | 1988 |
[Hemodynamic effects of clonidine in patients with heart failure during exercise].
Topics: Adult; Aged; Clonidine; Exercise; Female; Heart Failure; Hemodynamics; Humans; Male; Middle Aged | 1988 |
Postural influences on the hemodynamic responses to vasodilating drugs in congestive heart failure.
Topics: Adult; Aged; Blood Pressure; Cardiac Output; Clonidine; Female; Heart Failure; Heart Rate; Hemodynam | 1985 |
Clonidine withdrawal syndrome in a patient with heart failure.
Topics: Aged; Blood Pressure; Clonidine; Female; Heart Failure; Heart Rate; Humans; Nitroprusside; Pulmonary | 1985 |