Page last updated: 2024-10-25

clonidine and Heart Defects, Congenital

clonidine has been researched along with Heart Defects, Congenital in 4 studies

Clonidine: An imidazoline sympatholytic agent that stimulates ALPHA-2 ADRENERGIC RECEPTORS and central IMIDAZOLINE RECEPTORS. It is commonly used in the management of HYPERTENSION.
clonidine (amino form) : A clonidine that is 4,5-dihydro-1H-imidazol-2-amine in which one of the amino hydrogens is replaced by a 2,6-dichlorophenyl group.

Heart Defects, Congenital: Developmental abnormalities involving structures of the heart. These defects are present at birth but may be discovered later in life.

Research Excerpts

ExcerptRelevanceReference
"Clonidine is a useful analgesic-sedative agent; however, few data exist regarding its use in infants after congenital heart disease surgery."1.40Enteral absorption and haemodynamic response of clonidine in infants post-cardiac surgery. ( Arenas-Lopez, S; Durward, A; Manna, S; Mulla, H; Murdoch, IA; Tibby, SM, 2014)

Research

Studies (4)

TimeframeStudies, this research(%)All Research%
pre-19901 (25.00)18.7374
1990's0 (0.00)18.2507
2000's1 (25.00)29.6817
2010's2 (50.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Arenas-Lopez, S1
Mulla, H1
Manna, S1
Durward, A1
Murdoch, IA1
Tibby, SM1
Nguyen, KN1
Byrd, HS1
Tan, JM1
Pohl-Schickinger, A1
Lemmer, J1
Hübler, M1
Alexi-Meskishvili, V1
Redlin, M1
Berger, F1
Stiller, B1
Persico, L1

Clinical Trials (2)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Efficacy of Dexmedetomidine Versus Morphine as an Adjunct to Bupivacaine in Caudal Anesthesia for Pediatric Thoracic Surgeries. A Randomized Controlled Trial.[NCT04445636]50 participants (Actual)Interventional2020-06-28Completed
Efficacy of Clonidine in Reducing Iatrogenic-induced Opioid Dependence in Infants:[NCT01360450]Phase 2/Phase 312 participants (Actual)Interventional2011-07-31Terminated (stopped due to The study was treminated because of low accural)
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Time to Complete Detoxification

Time to complete detoxification is defined as 48 hrs off all opioids/benzodiazepines and study drug with acceptable withdrawal scores of <9 (on average we expect the infant to be enrolled in the study for 2-4 weeks). The scale used to assess withdrawal was the Modified Finnegan Neonatal Withdrawal Scale, which ranges from 0-41, 0 represents no withdrawal and 41 represent maximum withdrawal. (NCT01360450)
Timeframe: up to 4 weeks

,
Interventiondays (Mean)
total days on narcoticsduration on study drug in days
Control37.214.2
Treatment89.521

Other Studies

4 other studies available for clonidine and Heart Defects, Congenital

ArticleYear
Enteral absorption and haemodynamic response of clonidine in infants post-cardiac surgery.
    British journal of anaesthesia, 2014, Volume: 113, Issue:6

    Topics: Analgesics, Non-Narcotic; Analgesics, Opioid; Clonidine; Drug Administration Schedule; Heart Defects

2014
Caudal analgesia and cardiothoracic surgery: a look at postoperative pain scores in a pediatric population.
    Paediatric anaesthesia, 2016, Volume: 26, Issue:11

    Topics: Adolescent; Analgesics; Analgesics, Opioid; Anesthesia, Caudal; Anesthetics, Local; Bupivacaine; Car

2016
Intravenous clonidine infusion in infants after cardiovascular surgery.
    Paediatric anaesthesia, 2008, Volume: 18, Issue:3

    Topics: Analgesia; Analgesics; Analgesics, Opioid; Blood Pressure; Body Temperature; Clonidine; Female; Fent

2008
[Pathogenesis and therapy of acute pulmonary edema].
    Il Policlinico. Sezione pratica, 1972, Jan-01, Volume: 79, Issue:1

    Topics: Acute Disease; Brain Diseases; Cardiac Glycosides; Clonidine; Diuretics; Gas Poisoning; Heart Defect

1972