clonidine has been researched along with Hallux Abductovalgus in 2 studies
Clonidine: An imidazoline sympatholytic agent that stimulates ALPHA-2 ADRENERGIC RECEPTORS and central IMIDAZOLINE RECEPTORS. It is commonly used in the management of HYPERTENSION.
clonidine (amino form) : A clonidine that is 4,5-dihydro-1H-imidazol-2-amine in which one of the amino hydrogens is replaced by a 2,6-dichlorophenyl group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "This prospective, randomized, double-blinded study demonstrated that, when providing combined sciatic-femoral nerve block for hallux valgus repair, the addition of 1 microg/kg clonidine to 0." | 5.09 | Small-dose clonidine prolongs postoperative analgesia after sciatic-femoral nerve block with 0.75% ropivacaine for foot surgery. ( Aldegheri, G; Beccaria, P; Cappelleri, G; Casati, A; Fanelli, G; Magistris, L; Torri, G, 2000) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (50.00) | 18.2507 |
| 2000's | 1 (50.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Reinhart, DJ | 1 |
| Wang, W | 1 |
| Stagg, KS | 1 |
| Walker, KG | 1 |
| Bailey, PL | 1 |
| Walker, EB | 1 |
| Zaugg, SE | 1 |
| Casati, A | 1 |
| Magistris, L | 1 |
| Fanelli, G | 1 |
| Beccaria, P | 1 |
| Cappelleri, G | 1 |
| Aldegheri, G | 1 |
| Torri, G | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Prospective Triple-masked Randomized Controlled Trial Measuring Analgesia Duration of Dexamethasone, Buprenorphine, or Clonidine With Ropivacaine for Interscalene Nerve Block[NCT03117140] | Phase 4 | 160 participants (Actual) | Interventional | 2013-12-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Patients are assessed from needle removal to when they are no longer able to feel cold on the blocked extremity (NCT03117140)
Timeframe: Day one
| Intervention | minutes (Median) |
|---|---|
| Plain Ropivacaine | 6 |
| Ropivacaine + Buprenorphine | 3 |
| Ropivacaine + Clonidine | 6 |
| Ropivacaine + Dexamethasone | 4.5 |
Patients are called 1-3 days post-operatively to assess when the analgesia of their nerve block wore off (NCT03117140)
Timeframe: 1-3 days post-operative
| Intervention | minutes (Median) |
|---|---|
| Plain Ropivacaine | 911 |
| Ropivacaine + Buprenorphine | 1026.5 |
| Ropivacaine + Clonidine | 1181 |
| Ropivacaine + Dexamethasone | 982 |
Patients are called 1-3 days post-operatively to assess when motor component of their nerve block wore off (NCT03117140)
Timeframe: Day 1-3
| Intervention | minutes (Median) |
|---|---|
| Plain Ropivacaine | 1120 |
| Ropivacaine + Buprenorphine | 1198 |
| Ropivacaine + Clonidine | 1090 |
| Ropivacaine + Dexamethasone | 1143.5 |
Blood pressure changes in Second Stage Recovery Area for patients was looked at (NCT03117140)
Timeframe: Post-op Day 0 (baseline)
| Intervention | Participants (Count of Participants) |
|---|---|
| Plain Ropivacaine | 5 |
| Ropivacaine + Buprenorphine | 1 |
| Ropivacaine + Clonidine | 5 |
| Ropivacaine + Dexamethasone | 0 |
Patients are called 1-3 days post-operatively to assess if they had any side effects of the adjuvants such as nausea, vomiting or itching. There blood pressure is looked at pre-op and compared to post-op. Any prolonged PACU (Post Anesthesia Care Unit) stay for sedation is recorded. (NCT03117140)
Timeframe: 1-3 days
| Intervention | Participants (Count of Participants) |
|---|---|
| Plain Ropivacaine | 1 |
| Ropivacaine + Buprenorphine | 2 |
| Ropivacaine + Clonidine | 2 |
| Ropivacaine + Dexamethasone | 0 |
Patients itching was assessed post-op in the PACU. (NCT03117140)
Timeframe: Post-op day 0 (baseline)
| Intervention | Participants (Count of Participants) |
|---|---|
| Plain Ropivacaine | 5 |
| Ropivacaine + Buprenorphine | 2 |
| Ropivacaine + Clonidine | 6 |
| Ropivacaine + Dexamethasone | 3 |
Patients are called 1-3 days post-operatively to assess if they had any side effects of the adjuvants such as nausea, vomiting or itching. There blood pressure is looked at pre-op and compared to post-op. Any prolonged PACU (Post Anesthesia Care Unit) stay for sedation is recorded. (NCT03117140)
Timeframe: 1-3 days
| Intervention | Participants (Count of Participants) |
|---|---|
| Plain Ropivacaine | 4 |
| Ropivacaine + Buprenorphine | 9 |
| Ropivacaine + Clonidine | 2 |
| Ropivacaine + Dexamethasone | 3 |
PACU (Post-Anesthesia Care Unit) assessment of nausea (NCT03117140)
Timeframe: Post-op day 0 (Baseline)
| Intervention | Participants (Count of Participants) |
|---|---|
| Plain Ropivacaine | 4 |
| Ropivacaine + Buprenorphine | 9 |
| Ropivacaine + Clonidine | 2 |
| Ropivacaine + Dexamethasone | 9 |
Vomiting in PACU (Post-Anesthesia Care Unit) for patients was looked at (NCT03117140)
Timeframe: Post-op Day 0 (Baseline)
| Intervention | Participants (Count of Participants) |
|---|---|
| Plain Ropivacaine | 0 |
| Ropivacaine + Buprenorphine | 1 |
| Ropivacaine + Clonidine | 0 |
| Ropivacaine + Dexamethasone | 0 |
Blood pressure changes in PACU (Post-Anesthesia Care Unit) for patients was looked at (NCT03117140)
Timeframe: Post-op Day 0 (baseline)
| Intervention | Participants (Count of Participants) |
|---|---|
| Plain Ropivacaine | 8 |
| Ropivacaine + Buprenorphine | 3 |
| Ropivacaine + Clonidine | 7 |
| Ropivacaine + Dexamethasone | 2 |
Patients are called 1-3 days post-operatively to assess pain. Pain score is 0-10 scale with 0 is no pain and 10 is most severe pain. (NCT03117140)
Timeframe: Day 1-3
| Intervention | units on a scale (Median) |
|---|---|
| Plain Ropivacaine | 4 |
| Ropivacaine + Buprenorphine | 3 |
| Ropivacaine + Clonidine | 4 |
| Ropivacaine + Dexamethasone | 3 |
Patients are called 1-3 days post-operatively to assess if they had any side effects of the adjuvants such as nausea, vomiting or itching. There blood pressure is looked at pre-op and compared to post-op. Any prolonged PACU (Post Anesthesia Care Unit) stay for sedation is recorded. (NCT03117140)
Timeframe: 1-3 days
| Intervention | Participants (Count of Participants) |
|---|---|
| Plain Ropivacaine | 0 |
| Ropivacaine + Buprenorphine | 3 |
| Ropivacaine + Clonidine | 2 |
| Ropivacaine + Dexamethasone | 1 |
Patients are called 1-3 days post-operatively to assess when the sensory component of their nerve block wore off (NCT03117140)
Timeframe: Day 1-3
| Intervention | minutes (Median) |
|---|---|
| Plain Ropivacaine | 923.5 |
| Ropivacaine + Buprenorphine | 982 |
| Ropivacaine + Clonidine | 940.5 |
| Ropivacaine + Dexamethasone | 1066 |
Surgical length was recorded (NCT03117140)
Timeframe: Post op Day 0 (Baseline)
| Intervention | minutes (Median) |
|---|---|
| Plain Ropivacaine | 68.5 |
| Ropivacaine + Buprenorphine | 65 |
| Ropivacaine + Clonidine | 73.5 |
| Ropivacaine + Dexamethasone | 71 |
Surgical position was recorded (NCT03117140)
Timeframe: Post-op Day 0 (Baseline)
| Intervention | Participants (Count of Participants) | ||
|---|---|---|---|
| Beach Chair | Lateral | Supine | |
| Plain Ropivacaine | 38 | 2 | 0 |
| Ropivacaine + Buprenorphine | 31 | 6 | 3 |
| Ropivacaine + Clonidine | 31 | 7 | 2 |
| Ropivacaine + Dexamethasone | 32 | 6 | 2 |
2 trials available for clonidine and Hallux Abductovalgus
| Article | Year |
|---|---|
Postoperative analgesia after peripheral nerve block for podiatric surgery: clinical efficacy and chemical stability of lidocaine alone versus lidocaine plus clonidine.
Topics: Adrenergic alpha-Agonists; Adult; Analgesia; Analgesics; Analysis of Variance; Anesthetics, Local; A | 1996 |
Small-dose clonidine prolongs postoperative analgesia after sciatic-femoral nerve block with 0.75% ropivacaine for foot surgery.
Topics: Adult; Aged; Amides; Analgesics; Anesthetics, Local; Clonidine; Double-Blind Method; Female; Femoral | 2000 |