Page last updated: 2024-10-25

clonidine and Hallux Abductovalgus

clonidine has been researched along with Hallux Abductovalgus in 2 studies

Clonidine: An imidazoline sympatholytic agent that stimulates ALPHA-2 ADRENERGIC RECEPTORS and central IMIDAZOLINE RECEPTORS. It is commonly used in the management of HYPERTENSION.
clonidine (amino form) : A clonidine that is 4,5-dihydro-1H-imidazol-2-amine in which one of the amino hydrogens is replaced by a 2,6-dichlorophenyl group.

Research Excerpts

ExcerptRelevanceReference
"This prospective, randomized, double-blinded study demonstrated that, when providing combined sciatic-femoral nerve block for hallux valgus repair, the addition of 1 microg/kg clonidine to 0."5.09Small-dose clonidine prolongs postoperative analgesia after sciatic-femoral nerve block with 0.75% ropivacaine for foot surgery. ( Aldegheri, G; Beccaria, P; Cappelleri, G; Casati, A; Fanelli, G; Magistris, L; Torri, G, 2000)

Research

Studies (2)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (50.00)18.2507
2000's1 (50.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Reinhart, DJ1
Wang, W1
Stagg, KS1
Walker, KG1
Bailey, PL1
Walker, EB1
Zaugg, SE1
Casati, A1
Magistris, L1
Fanelli, G1
Beccaria, P1
Cappelleri, G1
Aldegheri, G1
Torri, G1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
A Prospective Triple-masked Randomized Controlled Trial Measuring Analgesia Duration of Dexamethasone, Buprenorphine, or Clonidine With Ropivacaine for Interscalene Nerve Block[NCT03117140]Phase 4160 participants (Actual)Interventional2013-12-31Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Block Set up Time

Patients are assessed from needle removal to when they are no longer able to feel cold on the blocked extremity (NCT03117140)
Timeframe: Day one

Interventionminutes (Median)
Plain Ropivacaine6
Ropivacaine + Buprenorphine3
Ropivacaine + Clonidine6
Ropivacaine + Dexamethasone4.5

Duration of Analgesia

Patients are called 1-3 days post-operatively to assess when the analgesia of their nerve block wore off (NCT03117140)
Timeframe: 1-3 days post-operative

Interventionminutes (Median)
Plain Ropivacaine911
Ropivacaine + Buprenorphine1026.5
Ropivacaine + Clonidine1181
Ropivacaine + Dexamethasone982

Motor Duration of Block

Patients are called 1-3 days post-operatively to assess when motor component of their nerve block wore off (NCT03117140)
Timeframe: Day 1-3

Interventionminutes (Median)
Plain Ropivacaine1120
Ropivacaine + Buprenorphine1198
Ropivacaine + Clonidine1090
Ropivacaine + Dexamethasone1143.5

Number of Patient With Blood Pressure Changes in the Second Stage Recovery Area

Blood pressure changes in Second Stage Recovery Area for patients was looked at (NCT03117140)
Timeframe: Post-op Day 0 (baseline)

InterventionParticipants (Count of Participants)
Plain Ropivacaine5
Ropivacaine + Buprenorphine1
Ropivacaine + Clonidine5
Ropivacaine + Dexamethasone0

Number of Patients Reporting Itching at Home

Patients are called 1-3 days post-operatively to assess if they had any side effects of the adjuvants such as nausea, vomiting or itching. There blood pressure is looked at pre-op and compared to post-op. Any prolonged PACU (Post Anesthesia Care Unit) stay for sedation is recorded. (NCT03117140)
Timeframe: 1-3 days

InterventionParticipants (Count of Participants)
Plain Ropivacaine1
Ropivacaine + Buprenorphine2
Ropivacaine + Clonidine2
Ropivacaine + Dexamethasone0

Number of Patients Reporting Itching in the PACU

Patients itching was assessed post-op in the PACU. (NCT03117140)
Timeframe: Post-op day 0 (baseline)

InterventionParticipants (Count of Participants)
Plain Ropivacaine5
Ropivacaine + Buprenorphine2
Ropivacaine + Clonidine6
Ropivacaine + Dexamethasone3

Number of Patients Reporting Nausea at Home

Patients are called 1-3 days post-operatively to assess if they had any side effects of the adjuvants such as nausea, vomiting or itching. There blood pressure is looked at pre-op and compared to post-op. Any prolonged PACU (Post Anesthesia Care Unit) stay for sedation is recorded. (NCT03117140)
Timeframe: 1-3 days

InterventionParticipants (Count of Participants)
Plain Ropivacaine4
Ropivacaine + Buprenorphine9
Ropivacaine + Clonidine2
Ropivacaine + Dexamethasone3

Number of Patients Reporting Nausea in the PACU

PACU (Post-Anesthesia Care Unit) assessment of nausea (NCT03117140)
Timeframe: Post-op day 0 (Baseline)

InterventionParticipants (Count of Participants)
Plain Ropivacaine4
Ropivacaine + Buprenorphine9
Ropivacaine + Clonidine2
Ropivacaine + Dexamethasone9

Number of Patients Vomiting in the PACU (Post-Anesthesia Care Unit)

Vomiting in PACU (Post-Anesthesia Care Unit) for patients was looked at (NCT03117140)
Timeframe: Post-op Day 0 (Baseline)

InterventionParticipants (Count of Participants)
Plain Ropivacaine0
Ropivacaine + Buprenorphine1
Ropivacaine + Clonidine0
Ropivacaine + Dexamethasone0

Number of Patients With Blood Pressure (BP) Changes in the PACU

Blood pressure changes in PACU (Post-Anesthesia Care Unit) for patients was looked at (NCT03117140)
Timeframe: Post-op Day 0 (baseline)

InterventionParticipants (Count of Participants)
Plain Ropivacaine8
Ropivacaine + Buprenorphine3
Ropivacaine + Clonidine7
Ropivacaine + Dexamethasone2

Pain Score Reported by Patients at First Phone Call

Patients are called 1-3 days post-operatively to assess pain. Pain score is 0-10 scale with 0 is no pain and 10 is most severe pain. (NCT03117140)
Timeframe: Day 1-3

Interventionunits on a scale (Median)
Plain Ropivacaine4
Ropivacaine + Buprenorphine3
Ropivacaine + Clonidine4
Ropivacaine + Dexamethasone3

Patient Reporting Vomiting at Home

Patients are called 1-3 days post-operatively to assess if they had any side effects of the adjuvants such as nausea, vomiting or itching. There blood pressure is looked at pre-op and compared to post-op. Any prolonged PACU (Post Anesthesia Care Unit) stay for sedation is recorded. (NCT03117140)
Timeframe: 1-3 days

InterventionParticipants (Count of Participants)
Plain Ropivacaine0
Ropivacaine + Buprenorphine3
Ropivacaine + Clonidine2
Ropivacaine + Dexamethasone1

Sensory Duration of Block

Patients are called 1-3 days post-operatively to assess when the sensory component of their nerve block wore off (NCT03117140)
Timeframe: Day 1-3

Interventionminutes (Median)
Plain Ropivacaine923.5
Ropivacaine + Buprenorphine982
Ropivacaine + Clonidine940.5
Ropivacaine + Dexamethasone1066

Surgical Length

Surgical length was recorded (NCT03117140)
Timeframe: Post op Day 0 (Baseline)

Interventionminutes (Median)
Plain Ropivacaine68.5
Ropivacaine + Buprenorphine65
Ropivacaine + Clonidine73.5
Ropivacaine + Dexamethasone71

Surgical Position

Surgical position was recorded (NCT03117140)
Timeframe: Post-op Day 0 (Baseline)

,,,
InterventionParticipants (Count of Participants)
Beach ChairLateralSupine
Plain Ropivacaine3820
Ropivacaine + Buprenorphine3163
Ropivacaine + Clonidine3172
Ropivacaine + Dexamethasone3262

Trials

2 trials available for clonidine and Hallux Abductovalgus

ArticleYear
Postoperative analgesia after peripheral nerve block for podiatric surgery: clinical efficacy and chemical stability of lidocaine alone versus lidocaine plus clonidine.
    Anesthesia and analgesia, 1996, Volume: 83, Issue:4

    Topics: Adrenergic alpha-Agonists; Adult; Analgesia; Analgesics; Analysis of Variance; Anesthetics, Local; A

1996
Small-dose clonidine prolongs postoperative analgesia after sciatic-femoral nerve block with 0.75% ropivacaine for foot surgery.
    Anesthesia and analgesia, 2000, Volume: 91, Issue:2

    Topics: Adult; Aged; Amides; Analgesics; Anesthetics, Local; Clonidine; Double-Blind Method; Female; Femoral

2000