Page last updated: 2024-10-25

clonidine and Growth Disorders

clonidine has been researched along with Growth Disorders in 102 studies

Clonidine: An imidazoline sympatholytic agent that stimulates ALPHA-2 ADRENERGIC RECEPTORS and central IMIDAZOLINE RECEPTORS. It is commonly used in the management of HYPERTENSION.
clonidine (amino form) : A clonidine that is 4,5-dihydro-1H-imidazol-2-amine in which one of the amino hydrogens is replaced by a 2,6-dichlorophenyl group.

Growth Disorders: Deviations from the average values for a specific age and sex in any or all of the following: height, weight, skeletal proportions, osseous development, or maturation of features. Included here are both acceleration and retardation of growth.

Research Excerpts

ExcerptRelevanceReference
"Clonidine therapy was continued regularly for 7 years until the age of 13 years, 11 months."5.29Effect of clonidine on the height of a child with glycogen storage disease type VI: a 13 year follow-up study. ( Asami, K; Asami, T; Kikuchi, T; Uchiyama, M, 1996)
"The arginine-clonidine growth hormone (GH) stimulation test causes hypotension, requiring intravenous fluids to stabilize blood pressure (BP) and delaying departure from clinic."3.74Oral hydration during growth hormone stimulation with clonidine. ( May, M; Rose, SR, 2007)
"Clonidine induced an increase in height velocity significantly different from that in control children only."2.67Effectiveness of growth-promoting therapies. Comparison among growth hormone, clonidine, and levodopa. ( Bernasconi, S; Ghizzoni, L; Muto, G; Spaggiari, R; Virdis, R; Volta, C, 1991)
" In contrast to other studies, this study shows no sustained increases in GH production or in improved growth velocity with long-term administration of a single daily dose of clonidine."2.66Lack of benefit of clonidine treatment for short stature in a double-blind, placebo-controlled trial. ( Pescovitz, OH; Tan, E, 1988)
" While medications for ADHD are generally well-tolerated, there are common, although less severe, as well as rare but severe adverse events AEs during treatment with ADHD drugs."2.49Practitioner review: current best practice in the management of adverse events during treatment with ADHD medications in children and adolescents. ( Banaschewski, T; Buitelaar, J; Coghill, D; Cortese, S; Danckaerts, M; Dittmann, RW; Graham, J; Holtmann, M; Sergeant, J; Taylor, E, 2013)
"Clonidine (0."1.43Clonidine-stimulated growth hormone concentrations (cut-off values) measured by immunochemiluminescent assay (ICMA) in children and adolescents with short stature. ( Borges, Mde F; Feltrin, AK; Ferreira, BP; Nascentes, GA; Palhares, HM; Resende, EA; Ribeiro, KA; Silva, AP; Teixeira, FC, 2016)
"Clonidine test proved to be an excellent test for initial assessment of GHD and may be used as a screening test for short stature in third world countries."1.35Growth hormone deficiency short stature in a third world adult endocrine clinic: usefulness of clonidine test in its diagnosis. ( Al-Ruhaily, AD; Malabu, UH, 2008)
"We report the two survivors of childhood ALL treated with chemotherapy without CR who required GH replacement due to absence of catch-up growth."1.33Growth hormone deficiency after chemotherapy for acute lymphoblastic leukemia in children who have not received cranial radiation. ( Haddy, TB; Mosher, RB; Nunez, SB; Reaman, GH, 2006)
"We studied 45 prepubertal children with IDDM (30 males, 15 females) over 1 year period."1.29Growth parameters, growth hormone (GH) response to clonidine and circulating insulin-like growth factor-I (IGF-I), free thyroxine (FT4) and cortisol concentrations in relation to glycaemic control in children with insulin-dependent diabetes mellitus. ( Ahmed, HI; Asfour, MG; Soliman, AT, 1996)
"Clonidine therapy was continued regularly for 7 years until the age of 13 years, 11 months."1.29Effect of clonidine on the height of a child with glycogen storage disease type VI: a 13 year follow-up study. ( Asami, K; Asami, T; Kikuchi, T; Uchiyama, M, 1996)
" The effect of chronic administration of GH (8-24 months) on plasma GH responses to GHRH, clonidine and spontaneous GH secretion were studied in 17 NSD patients."1.28Chronic growth hormone administration does not suppress endogenous growth hormone secretion in patients with neurosecretory growth hormone dysfunction. ( Lieberman, E; Limoni, Y; Zadik, Z, 1991)
"Clonidine was given orally in a daily dose of 0."1.28Augmentation of growth hormone secretion in children with constitutional growth delay by short term clonidine administration: a pulse amplitude-modulated phenomenon. ( Cella, SG; Fanni, T; Loche, S; Müller, EE; Pintor, C; Puggioni, R, 1989)

Research

Studies (102)

TimeframeStudies, this research(%)All Research%
pre-199031 (30.39)18.7374
1990's44 (43.14)18.2507
2000's16 (15.69)29.6817
2010's9 (8.82)24.3611
2020's2 (1.96)2.80

Authors

AuthorsStudies
Sodero, G2
Mariani, F2
Caprarelli, M2
Agazzi, C2
Quarta, L2
Benacquista, L2
Rigante, D2
Clelia, C2
Iwayama, H1
Kitagawa, S1
Sada, J1
Miyamoto, R1
Hayakawa, T1
Kuroyanagi, Y1
Muto, T1
Kurahashi, H1
Ohashi, W1
Takagi, J1
Okumura, A1
Bhat, N1
Dulmovits, E1
Lane, A1
Messina, C1
Wilson, T1
Christoforidis, A1
Triantafyllou, P1
Slavakis, A1
Katzos, G2
Al Khalifah, R1
Moisan, L1
Bui, H1
Gillis, D2
Magiel, E1
Terespolsky, N1
Naugolny, L1
Strich, D1
Borges, Mde F1
Teixeira, FC1
Feltrin, AK1
Ribeiro, KA1
Nascentes, GA1
Resende, EA1
Ferreira, BP1
Silva, AP1
Palhares, HM1
Molina, S1
Paoli, M1
Camacho, N1
Arata-Bellabarba, G1
Lanes, R2
Muster, L1
Zangen, DH1
Nesher, R1
Hirsch, HJ1
Muster, Z1
Mahachoklertwattana, P1
Yimsumruay, T1
Poomthavorn, P1
Chuansumrit, A1
Khlairit, P1
Loche, S8
Guzzetti, C1
Pilia, S1
Ibba, A1
Civolani, P1
Porcu, M1
Minerba, L1
Casini, MR1
Giacomozzi, C1
Spadoni, GL2
Pedicelli, S1
Scirè, G2
Cristofori, L1
Peschiaroli, E1
Deodati, A1
Cambiaso, P1
Cappa, M2
Cianfarani, S3
Cortese, S1
Holtmann, M1
Banaschewski, T1
Buitelaar, J1
Coghill, D1
Danckaerts, M1
Dittmann, RW1
Graham, J1
Taylor, E1
Sergeant, J1
Tondinelli, T1
Boemi, S2
Boscherini, B2
Radetti, G1
Buzi, F1
Cassar, W1
Paganini, C1
Stacul, E1
Maghnie, M1
Evans, C1
Gregory, JW1
Silvani, P1
Camporesi, A1
Zoia, E1
Leoncino, S1
Salvo, I1
Marini, JC2
Bordenick, S2
Chrousos, GP2
Haddy, TB1
Mosher, RB1
Nunez, SB1
Reaman, GH1
Borghi, MM1
Longui, CA1
Calliari, LE1
Faria, CD1
Kochi, C1
Monte, O1
Hilczer, M2
Smyczynska, J2
Stawerska, R1
Lewinski, A2
Gloria-Bottini, F1
Amante, A2
Lucarelli, P1
Saccucci, P1
Martinoli, R1
Bottini, E2
May, M1
Rose, SR1
Al-Ruhaily, AD1
Malabu, UH1
Slover, RH1
Klingensmith, GJ1
Gotlin, RW1
Radcliffe, J1
Fraser, NC1
Seth, J1
Brown, NS1
Pombo Arias, M1
Pintor, C8
Puggioni, R5
Fanni, V1
Cella, SG8
Villa, A1
Locatelli, V4
Müller, EE8
Hinkel, GK1
Schlagehan, IM1
Schollberg, K1
Kühne, H1
Spagnoli, A1
Argirò, G1
Vaccaro, F1
Manca Bitti, ML1
Soliman, AT7
Mohsin, N1
al Hasani, M1
Elbualy, M1
Harsoulis, F1
Papadopoulou, M1
Athanasiou, M1
Sava, K1
Bercu, BB4
Menon, PS1
Gupta, P1
Karmarkar, MG1
Tapanainen, PJ1
Blethen, SL2
Albertsson-Wikland, K1
Faklis, EJ1
Chasalow, FI2
Rochiccioli, P4
Enjaume, C2
Tauber, MT3
Pienkowski, C3
Oliver, I1
Castro-Magana, M2
Angulo, M2
Canas, JA1
Mazur, B1
Wilson, DM1
Dotson, RJ1
Neely, EK1
Cohen, P1
Hintz, RL1
Rosenfeld, RG1
Allen, DB1
Heavner, G1
Rose, S1
Hintz, R1
Rosenfeld, R1
Fortes, ES1
Chacra, AR1
Kunii, HS1
Vieira, JG1
Russo, EM1
Ammenti, A1
Volta, C2
Bernasconi, S2
Madina, EH1
Abdel Fattah, M1
el Zalabany, MM1
Asfour, M2
Morsi, MR1
Frank, GR1
Cheung, PT1
Horn, JA1
Alfaro, MP1
Smith, EP1
Chernausek, SD1
Ahmed, HI1
Asfour, MG1
Asami, T1
Kikuchi, T1
Asami, K1
Uchiyama, M1
Rotenstein, D1
Reigel, DH1
Lucke, JF1
Durá Travé, T2
Juste Ruiz, M1
González Montero, R1
Gutiérrez Terán, M1
Mauri Dot, M1
Moya Benavent, M2
Roman, J1
Villaizán, CJ1
García-Foncillas, J1
Salvador, J1
Sierrasesúmaga, L1
Cavallo, L2
Gurrado, R1
Gallo, F1
Zacchino, C1
De Mattia, D1
Tatò, L1
el Banna, N2
alSalmi, I1
De Silva, V1
Craig, A1
Ansari, BM3
Pellini, C1
De Angelis, R1
di Natale, B1
Lukezic, M1
Mora, S1
Chiumello, G1
Theodoridis, C1
Ladis, V1
Papatheodorou, A1
Berdousi, H1
Palamidou, F1
Evagelopoulou, C1
Athanassaki, K1
Konstantoura, O1
Kattamis, C1
Van den Broeck, J1
Hering, P1
Van de Lely, A1
Hokken-Koelega, A1
Tsatsoulis, A1
Siamopoulou, A1
Petsoukis, C1
Challa, A1
Bairaktari, E1
Seferiadis, K1
elZalabany, MM1
Mazloum, Y1
Bedair, SM1
Ragab, MS1
Rogol, AD1
Muñóz-Hoyos, A1
Fernández-García, JM1
Molina-Carballo, A1
Macías, M1
Escames, G1
Ruiz-Cosano, C1
Acuña-Castroviejo, D1
Madkour, A1
Galil, MA1
El Zalabany, M1
Aziz, SM1
Lucarini, N1
Bottini, N1
Faggioni, G1
Dorantes-Alvarez, L1
Coyote-Estrada, N1
Parra-Paredes, S1
García-Morales, L1
Metlich-Medlich, B1
Acquafredda, A1
Liuzzi, S1
Russo, R1
Zecchino, C1
Leuzzi, R1
Giobbe, T1
Piacente, L1
Moore, WV3
Moore, KC1
Gifford, R1
Hollowell, JG3
Donaldson, DL3
Pan, F1
Stevenson, JL1
Gifford, RA2
Tesarová, A2
Marsálková, D2
Slavícková, M2
Marek, J2
Nedvídková, J2
Zadik, Z4
Limoni, Y1
Lieberman, E1
Uboldi, F2
Ghizzoni, L1
Muto, G1
Spaggiari, R1
Virdis, R1
Rudolf, MC1
Linn, S1
Hochberg, Z1
Moreno Esteban, B1
Monereo Mejías, S1
Rodríguez Poyo-Guerrero, P1
Moreno Esteban, FJ1
Tresguerres, JA1
Ghigo, E1
Mazza, E1
Bellone, J1
Arvat, E1
Imperiale, E1
Procopio, M1
Camanni, F1
Chalew, SA2
Gilula, Z1
Kowarski, AA2
Casanova Fernández, M1
Nussbaum, MP1
Jacobson, MS1
Shenker, IR1
Feldman, J1
Stabilini, L1
Suri, D1
Brook, CG1
Hindmarsh, P1
Basile, V1
Marino, A1
Pan, FP1
Buades Esplá, A1
Corda, R2
Lippe, B1
Frasier, SD1
Pescovitz, OH1
Tan, E1
Fanni, T1
Root, AW2
Shulman, DI2
Lampis, A1
Fuentes, B1
Castelar, ME1
Cañas, A1
Espinoza, B1
Rymkiewicz-Kluczyńska, B1
Szarras-Czapnik, M1
Romer, T1
Batista, MC1
Arnhold, IJ1
Mendonça, BB1
D'Abronzo, FH1
Bloise, W1
Nicolau, W1
Chessa Ricotti, G1
Martini, E1
Pietraperzia, M1
Consumi, I1
Panagia, P1
Shulman, D1
Spiliotis, BE1
Bohorquez, L1
Leal, V1
Hernández, G1
Borges, M1
Hurtado, E1
Moncada, G1
Raiti, S1
Massarano, AA1

Clinical Trials (3)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Therapeutic Use of Repetitive Transcranial Magnetic Stimulation (rTMS) in Pediatric Autism Spectrum Disorder (ASD) and Attention Deficit Hyperactivity Cohorts (ADHD): a Randomized, Sham-controlled Study.[NCT06069323]80 participants (Anticipated)Interventional2023-06-01Recruiting
Studies of Growth Deficiency and Growth Hormone Treatment in Children With Osteogenesis Imperfecta Types III and IV[NCT00001305]Phase 342 participants (Actual)Interventional1991-11-05Completed
Evaluation and Intervention for Ambulation, Growth, and Basilar Invagination in Osteogenesis Imperfecta[NCT00001594]88 participants (Actual)Observational1997-01-29Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Proportion of Subjects Who Met Criteria of Increase in Growth Rate Since Baseline.

The proportion of subjects who met the study criteria of at least 50% increase in growth rate since baseline. (NCT00001305)
Timeframe: 1 year

InterventionParticipants (Count of Participants)
Growth Hormone25

Reviews

7 reviews available for clonidine and Growth Disorders

ArticleYear
Growth hormone responses during arginine and clonidine stimulation test: Correlations with patients' auxological and metabolic parameters in a single centre study.
    Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society, 2023, Volume: 68

    Topics: Arginine; Child; Clonidine; Dwarfism, Pituitary; Growth Disorders; Growth Hormone; Human Growth Horm

2023
Growth hormone responses during arginine and clonidine stimulation test: Correlations with patients' auxological and metabolic parameters in a single centre study.
    Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society, 2023, Volume: 68

    Topics: Arginine; Child; Clonidine; Dwarfism, Pituitary; Growth Disorders; Growth Hormone; Human Growth Horm

2023
Growth hormone responses during arginine and clonidine stimulation test: Correlations with patients' auxological and metabolic parameters in a single centre study.
    Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society, 2023, Volume: 68

    Topics: Arginine; Child; Clonidine; Dwarfism, Pituitary; Growth Disorders; Growth Hormone; Human Growth Horm

2023
Growth hormone responses during arginine and clonidine stimulation test: Correlations with patients' auxological and metabolic parameters in a single centre study.
    Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society, 2023, Volume: 68

    Topics: Arginine; Child; Clonidine; Dwarfism, Pituitary; Growth Disorders; Growth Hormone; Human Growth Horm

2023
Practitioner review: current best practice in the management of adverse events during treatment with ADHD medications in children and adolescents.
    Journal of child psychology and psychiatry, and allied disciplines, 2013, Volume: 54, Issue:3

    Topics: Adolescent; Atomoxetine Hydrochloride; Attention Deficit Disorder with Hyperactivity; Blood Pressure

2013
[Progress in the study of growth retardation].
    Anales espanoles de pediatria, 1984, Oct-15, Volume: 21, Issue:5

    Topics: Adolescent; Age Determination by Skeleton; Child; Child, Preschool; Chromosome Aberrations; Chromoso

1984
Interpretative difficulties with growth hormone provocative retesting in childhood-onset growth hormone deficiency.
    Hormone research, 1999, Volume: 51, Issue:1

    Topics: Adult; Arginine; Child; Clonidine; Female; Growth Disorders; Growth Hormone-Releasing Hormone; Human

1999
Neuroactive drugs in growth disorders.
    Acta paediatrica Scandinavica. Supplement, 1990, Volume: 367

    Topics: Bromocriptine; Central Nervous System; Child; Clonidine; False Negative Reactions; Growth Disorders;

1990
[Central and peripheral alpha-agonist and antagonist drugs in pharmacology and therapy].
    La Clinica terapeutica, 1989, Dec-31, Volume: 131, Issue:6

    Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Blood Pressure; Cardiac Output, Lo

1989
Clonidine treatment in children with short stature.
    Journal of endocrinological investigation, 1988, Volume: 11, Issue:10

    Topics: Body Height; Bromocriptine; Child; Clonidine; Growth Disorders; Growth Hormone; Humans; Levodopa

1988

Trials

10 trials available for clonidine and Growth Disorders

ArticleYear
Endocrine aspects of growth deficiency in OI.
    Connective tissue research, 1995, Volume: 31, Issue:4

    Topics: Adolescent; Bone Diseases, Endocrine; Bone Matrix; Calcification, Physiologic; Child; Child, Prescho

1995
Transdermal estradiol priming during clonidine stimulation test in non-growth hormone deficient children with short stature: a pilot study.
    Journal of pediatric endocrinology & metabolism : JPEM, 2006, Volume: 19, Issue:3

    Topics: Administration, Cutaneous; Adolescent; Body Height; Child; Child, Preschool; Clonidine; Drug Interac

2006
Limitations of clinical utility of growth hormone stimulating tests in diagnosing children with short stature.
    Endocrine regulations, 2006, Volume: 40, Issue:3

    Topics: Adolescent; Child; Clonidine; Diagnostic Errors; False Negative Reactions; Female; Glucagon; Growth

2006
Effects of estrogen on growth hormone following clonidine stimulation.
    American journal of diseases of children (1960), 1993, Volume: 147, Issue:1

    Topics: Administration, Oral; Adolescent; Arginine; California; Child; Child, Preschool; Clonidine; Decision

1993
Effects of nightly clonidine administration on growth velocity in short children without growth hormone deficiency: a double-blind, placebo-controlled study.
    The Journal of pediatrics, 1993, Volume: 122, Issue:1

    Topics: Administration, Oral; Age Determination by Skeleton; Body Height; Bone Development; Child; Clonidine

1993
[Sensitivity of the clonidine and guanfacine tests (alpha-2-adrenergic agonists) as pharmacologic stimulants of growth hormone. Effects on plasma cortisol].
    Anales espanoles de pediatria, 1996, Volume: 45, Issue:6

    Topics: Adrenergic alpha-Agonists; Child; Clonidine; Female; Growth Disorders; Guanfacine; Human Growth Horm

1996
GH response to provocation and circulating IGF-I and IGF-binding protein-3 concentrations, the IGF-I generation test and clinical response to GH therapy in children with beta-thalassaemia.
    European journal of endocrinology, 1998, Volume: 138, Issue:4

    Topics: Adolescent; beta-Thalassemia; Child; Clonidine; Drug Resistance; Female; Glucagon; Growth Disorders;

1998
Effectiveness of growth-promoting therapies. Comparison among growth hormone, clonidine, and levodopa.
    American journal of diseases of children (1960), 1991, Volume: 145, Issue:2

    Topics: Body Height; Child; Clonidine; Female; Growth Disorders; Growth Hormone; Humans; Levodopa; Male

1991
Clonidine treatment for short stature.
    Lancet (London, England), 1987, May-30, Volume: 1, Issue:8544

    Topics: Administration, Oral; Adolescent; Age Determination by Skeleton; Body Height; Child; Child, Preschoo

1987
Lack of benefit of clonidine treatment for short stature in a double-blind, placebo-controlled trial.
    Lancet (London, England), 1988, Oct-15, Volume: 2, Issue:8616

    Topics: Age Determination by Skeleton; Body Height; Child; Child, Preschool; Clinical Trials as Topic; Cloni

1988

Other Studies

85 other studies available for clonidine and Growth Disorders

ArticleYear
Insulin-like growth factor-1 level is a poor diagnostic indicator of growth hormone deficiency.
    Scientific reports, 2021, 08-09, Volume: 11, Issue:1

    Topics: Algorithms; Arginine; Biomarkers; Body Height; Child; Child, Preschool; Clonidine; Cross-Sectional S

2021
Combined simultaneous arginine clonidine stimulation test: Timing of peak growth hormone (GH) concentration and correlation with clinical indices of GH status.
    Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society, 2018, Volume: 40

    Topics: Antihypertensive Agents; Arginine; Biomarkers; Child; Clonidine; Female; Follow-Up Studies; Growth D

2018
Clonidine and glucagon stimulation for testing growth hormone secretion in children and adolescents: can we make it with fewer samples?
    Journal of endocrinological investigation, 2013, Volume: 36, Issue:11

    Topics: Adolescent; Child; Clonidine; False Positive Reactions; Female; Glucagon; Growth Disorders; Human Gr

2013
The shortened combined clonidine and arginine test for growth hormone deficiency is practical and specific: a diagnostic accuracy study.
    Journal of pediatric endocrinology & metabolism : JPEM, 2016, Volume: 29, Issue:3

    Topics: Arginine; Biomarkers; Child; Clonidine; Cross-Sectional Studies; Diagnostic Techniques, Endocrine; F

2016
CLONIDINE STIMULATION TEST FOR GH DEFICIENCY: A NEW LOOK AT SAMPLE TIMING.
    Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists, 2016, Volume: 22, Issue:3

    Topics: Adolescent; Blood Specimen Collection; Child; Child, Preschool; Clonidine; Diagnostic Techniques, En

2016
Clonidine-stimulated growth hormone concentrations (cut-off values) measured by immunochemiluminescent assay (ICMA) in children and adolescents with short stature.
    Clinics (Sao Paulo, Brazil), 2016, Volume: 71, Issue:4

    Topics: Adolescent; Adrenergic alpha-2 Receptor Agonists; Body Height; Case-Control Studies; Child; Child, P

2016
Is testosterone and estrogen priming prior to clonidine useful in the evaluation of the growth hormone status of short peripubertal children?
    Journal of pediatric endocrinology & metabolism : JPEM, 2008, Volume: 21, Issue:3

    Topics: Administration, Oral; Adolescent; Adrenergic alpha-Agonists; Body Height; Child; Clonidine; Drug Int

2008
Arginine and clonidine stimulation tests for growth hormone deficiency revisited--do we really need so many samples?
    Journal of pediatric endocrinology & metabolism : JPEM, 2009, Volume: 22, Issue:3

    Topics: Adolescent; Arginine; Child; Child, Preschool; Clonidine; Diagnostic Techniques, Endocrine; Female;

2009
Acute effects of blood transfusion on growth hormone and insulin-like growth factor-1 levels in children with thalassemia.
    Hormone research in paediatrics, 2011, Volume: 75, Issue:4

    Topics: Adolescent; Anemia; beta-Thalassemia; Blood Transfusion; Child; Child, Preschool; Clonidine; Cross-S

2011
Effect of body mass index on the growth hormone response to clonidine stimulation testing in children with short stature.
    Clinical endocrinology, 2011, Volume: 74, Issue:6

    Topics: Adolescent; Adrenergic alpha-2 Receptor Agonists; Adult; Analysis of Variance; Body Mass Index; Chil

2011
Responses to GHRH plus arginine test are more concordant with IGF-I circulating levels than responses to arginine and clonidine provocative tests.
    Journal of endocrinological investigation, 2012, Volume: 35, Issue:8

    Topics: Arginine; Child; Clonidine; Female; Growth Disorders; Growth Hormone-Releasing Hormone; Human Growth

2012
Height velocity and IGF-I assessment in the diagnosis of childhood onset GH insufficiency: do we still need a second GH stimulation test?
    Clinical endocrinology, 2002, Volume: 57, Issue:2

    Topics: Arginine; Body Height; Child; Clonidine; Female; Growth Disorders; Growth Hormone; Growth Hormone-Re

2002
Growth hormone secretory pattern and response to treatment in children with short stature followed to adult height.
    Clinical endocrinology, 2003, Volume: 59, Issue:1

    Topics: Adolescent; Adrenergic alpha-Agonists; Analysis of Variance; Arginine; Body Height; Child; Clonidine

2003
The investigation of short stature: a survey of practice in Wales and suggested practical guidelines.
    Journal of clinical pathology, 2004, Volume: 57, Issue:2

    Topics: Child; Child, Preschool; Clonidine; Growth Disorders; Health Care Surveys; Human Growth Hormone; Hum

2004
Anesthetic management in a child with Coffin-Siris syndrome.
    Paediatric anaesthesia, 2004, Volume: 14, Issue:8

    Topics: Abnormalities, Multiple; Amides; Analgesia, Epidural; Analgesics; Anesthetics, Inhalation; Anestheti

2004
Growth hormone deficiency after chemotherapy for acute lymphoblastic leukemia in children who have not received cranial radiation.
    Pediatric blood & cancer, 2006, Volume: 46, Issue:2

    Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Arginine; Body Height; Child; Child, Pre

2006
Stability of IGF-I concentration despite divergent results of repeated GH stimulating tests indicates poor reproducibility of test results.
    Endocrine regulations, 2006, Volume: 40, Issue:2

    Topics: Adolescent; Chemistry, Clinical; Child; Clonidine; Endocrinology; Female; Glucagon; Growth Disorders

2006
Functional aspects of genetic variability in the GH genomic region.
    The Journal of endocrinology, 2007, Volume: 193, Issue:1

    Topics: Alleles; Area Under Curve; Case-Control Studies; Chi-Square Distribution; Clonidine; Growth Disorder

2007
Oral hydration during growth hormone stimulation with clonidine.
    Journal of pediatric nursing, 2007, Volume: 22, Issue:5

    Topics: Adolescent; Arginine; Carbonated Beverages; Child; Child, Preschool; Clinical Nursing Research; Clon

2007
Growth hormone deficiency short stature in a third world adult endocrine clinic: usefulness of clonidine test in its diagnosis.
    Indian journal of medical sciences, 2008, Volume: 62, Issue:4

    Topics: Adolescent; Adrenergic alpha-Agonists; Body Height; Child; Clonidine; Developing Countries; Female;

2008
A comparison of clonidine and standard provocative agents of growth hormone.
    American journal of diseases of children (1960), 1984, Volume: 138, Issue:3

    Topics: Adolescent; Adrenocorticotropic Hormone; Adult; Arginine; Blood Glucose; Child; Clonidine; Female; G

1984
Clonidine is a better test for growth hormone deficiency than insulin hypoglycaemia.
    Archives of disease in childhood, 1983, Volume: 58, Issue:5

    Topics: Adolescent; Blood Glucose; Child; Child, Preschool; Clonidine; False Positive Reactions; Female; Gro

1983
Growth-hormone releasing factor and clonidine in children with constitutional growth delay. Evidence for defective pituitary growth hormone reserve.
    Journal of endocrinological investigation, 1984, Volume: 7, Issue:3

    Topics: Child; Clonidine; Growth Disorders; Growth Hormone; Growth Hormone-Releasing Hormone; Humans; Male;

1984
[Stimulation of growth hormone by clonidine in children with growth retardation].
    Kinderarztliche Praxis, 1984, Volume: 52, Issue:11

    Topics: Adolescent; Adult; Age Factors; Child; Child, Preschool; Clonidine; Growth Disorders; Growth Hormone

1984
Is IGF binding protein-3 assessment helpful for the diagnosis of GH deficiency?
    Clinical endocrinology, 1995, Volume: 43, Issue:1

    Topics: Adolescent; Anthropometry; Arginine; Carrier Proteins; Child; Child, Preschool; Clonidine; Female; G

1995
Defective clonidine-induced growth hormone secretion and normal thyroid and adrenal functions in prepubertal children with chronic renal insufficiency (CRF).
    Journal of tropical pediatrics, 1995, Volume: 41, Issue:4

    Topics: Adolescent; Adrenal Glands; Adrenocorticotropic Hormone; Anthropometry; Child; Child, Preschool; Clo

1995
Circadian growth hormone secretion in short multitransfused prepubertal children with thalassaemia major.
    European journal of pediatrics, 1995, Volume: 154, Issue:6

    Topics: Adolescent; beta-Thalassemia; Case-Control Studies; Child; Circadian Rhythm; Clonidine; Growth Disor

1995
Neurosecretory dysfunction and parasellar lesions.
    Current therapy in endocrinology and metabolism, 1994, Volume: 5

    Topics: Adolescent; Arginine; Child; Clonidine; Growth Disorders; Growth Hormone; Humans; Hypopituitarism; H

1994
High and low dose clonidine tests for the diagnosis of growth hormone deficiency.
    Indian pediatrics, 1994, Volume: 31, Issue:2

    Topics: Administration, Oral; Adolescent; Child; Child, Preschool; Clonidine; Female; Growth Disorders; Grow

1994
Circulating immunoreactive growth hormone releasing hormone concentrations and growth hormone response to growth hormone releasing hormone in short children.
    European journal of pediatrics, 1993, Volume: 152, Issue:12

    Topics: Adolescent; Body Constitution; Child; Child Development; Child, Preschool; Clonidine; Female; Growth

1993
Circulating growth hormone isoforms in girls with Turner's syndrome.
    The Journal of clinical endocrinology and metabolism, 1994, Volume: 78, Issue:6

    Topics: Adolescent; Adult; Antibodies, Monoclonal; Blood Specimen Collection; Child; Child, Preschool; Chrom

1994
[Statistic study of 5,473 somatotropin secretion stimulation pharmacologic tests (n=9). Proposed weighting coefficient].
    Annales de pediatrie, 1993, Volume: 40, Issue:7

    Topics: Adolescent; Age Determination by Skeleton; Arginine; Betaxolol; Child; Child, Preschool; Clonidine;

1993
Clonidine treatment for short children.
    The Journal of pediatrics, 1993, Volume: 123, Issue:1

    Topics: Child; Clonidine; Growth Disorders; Growth Hormone; Humans

1993
The growth hormone and somatomedin axis in short children with osteogenesis imperfecta.
    The Journal of clinical endocrinology and metabolism, 1993, Volume: 76, Issue:1

    Topics: Adolescent; Arginine; Body Height; Child; Child, Preschool; Clonidine; Female; Growth Disorders; Gro

1993
The growth hormone and somatomedin axis in short children with osteogenesis imperfecta.
    The Journal of clinical endocrinology and metabolism, 1993, Volume: 76, Issue:1

    Topics: Adolescent; Arginine; Body Height; Child; Child, Preschool; Clonidine; Female; Growth Disorders; Gro

1993
The growth hormone and somatomedin axis in short children with osteogenesis imperfecta.
    The Journal of clinical endocrinology and metabolism, 1993, Volume: 76, Issue:1

    Topics: Adolescent; Arginine; Body Height; Child; Child, Preschool; Clonidine; Female; Growth Disorders; Gro

1993
The growth hormone and somatomedin axis in short children with osteogenesis imperfecta.
    The Journal of clinical endocrinology and metabolism, 1993, Volume: 76, Issue:1

    Topics: Adolescent; Arginine; Body Height; Child; Child, Preschool; Clonidine; Female; Growth Disorders; Gro

1993
Nocturnal urinary growth hormone excretion as a criterion for growth hormone deficiency.
    Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas, 1995, Volume: 28, Issue:4

    Topics: Adolescent; Age Determination by Skeleton; Child; Circadian Rhythm; Clonidine; Female; Growth Disord

1995
No response to growth stimulating treatments in a child with hypercalciuria and short stature (Royer syndrome)
    European journal of pediatrics, 1995, Volume: 154, Issue:11

    Topics: Body Height; Bone Diseases, Metabolic; Calcium; Child, Preschool; Clonidine; Growth Disorders; Growt

1995
Nocturnal growth hormone (GH) secretion and GH response to clonidine provocation in children before and after long-term prednisone therapy.
    Journal of tropical pediatrics, 1995, Volume: 41, Issue:6

    Topics: Adrenergic alpha-Agonists; Child; Child, Preschool; Circadian Rhythm; Clonidine; Egypt; Female; Gluc

1995
Predicting the growth response to growth hormone in patients with intrauterine growth retardation.
    Clinical endocrinology, 1996, Volume: 44, Issue:6

    Topics: Body Height; Child; Child, Preschool; Clonidine; Drug Administration Schedule; Female; Fetal Growth

1996
Growth parameters, growth hormone (GH) response to clonidine and circulating insulin-like growth factor-I (IGF-I), free thyroxine (FT4) and cortisol concentrations in relation to glycaemic control in children with insulin-dependent diabetes mellitus.
    Journal of tropical pediatrics, 1996, Volume: 42, Issue:4

    Topics: Body Mass Index; Case-Control Studies; Child; Child, Preschool; Clonidine; Diabetes Mellitus, Type 1

1996
Effect of clonidine on the height of a child with glycogen storage disease type VI: a 13 year follow-up study.
    Acta paediatrica Japonica : Overseas edition, 1996, Volume: 38, Issue:5

    Topics: Administration, Oral; Adolescent; Body Height; Child; Clonidine; Follow-Up Studies; Glucagon; Glucos

1996
Growth of growth hormone-treated and nontreated children before and after tethered spinal cord release.
    Pediatric neurosurgery, 1996, Volume: 24, Issue:5

    Topics: Adrenergic alpha-Agonists; Anthropometry; Child; Child, Preschool; Clonidine; Female; Growth Disorde

1996
Growth and growth hormone secretion in children with cancer treated with chemotherapy.
    The Journal of pediatrics, 1997, Volume: 131, Issue:1 Pt 1

    Topics: Adolescent; Adrenergic alpha-Agonists; Adult; Age Factors; Antibiotics, Antineoplastic; Antineoplast

1997
Growth deficiency in polytransfused beta-thalassaemia patients is not growth hormone dependent.
    Clinical endocrinology, 1997, Volume: 46, Issue:6

    Topics: Adolescent; Adrenergic alpha-Agonists; Adult; beta-Thalassemia; Blood Transfusion; Body Height; Bone

1997
Growth hormone secretion and circulating insulin-like growth factor-I (IGF-I) and IGF binding protein-3 concentrations in children with sickle cell disease.
    Metabolism: clinical and experimental, 1997, Volume: 46, Issue:11

    Topics: Adrenergic alpha-Agonists; Child; Child, Preschool; Clonidine; Cohort Studies; Ferritins; Glucagon;

1997
Dexamethasone in the diagnostic work-up of growth hormone deficiency.
    Clinical endocrinology, 1998, Volume: 48, Issue:2

    Topics: Administration, Oral; Adolescent; Adrenergic alpha-Agonists; Area Under Curve; Child; Child, Prescho

1998
Growth and management of short stature in thalassaemia major.
    Journal of pediatric endocrinology & metabolism : JPEM, 1998, Volume: 11 Suppl 3

    Topics: Adolescent; Adult; beta-Thalassemia; Blood Transfusion; Body Height; Child; Clonidine; Female; Growt

1998
Study of growth hormone secretion and action in growth-retarded children with juvenile chronic arthritis (JCA).
    Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society, 1999, Volume: 9, Issue:2

    Topics: Adolescent; Adrenergic alpha-Agonists; Arthritis, Juvenile; Child; Clonidine; Female; Glucose Tolera

1999
Spontaneous and provoked growth hormone (GH) secretion and insulin-like growth factor I (IGF-I) concentration in patients with beta thalassaemia and delayed growth.
    Journal of tropical pediatrics, 1999, Volume: 45, Issue:6

    Topics: Adolescent; Adult; beta-Thalassemia; Circadian Rhythm; Clonidine; Female; Glucagon; Growth Disorders

1999
Effect of clonidine on plasma ACTH, cortisol and melatonin in children.
    Journal of pineal research, 2000, Volume: 29, Issue:1

    Topics: Adrenergic alpha-Agonists; Adrenocorticotropic Hormone; Animals; Child; Clonidine; Female; Growth Di

2000
Growth parameters and endocrine function in relation to echocardiographic parameters in children with ventricular septal defect without heart failure.
    Journal of tropical pediatrics, 2001, Volume: 47, Issue:3

    Topics: Body Mass Index; Case-Control Studies; Child; Child, Preschool; Clonidine; Egypt; Female; Growth Dis

2001
The genetics of signal transduction and the outcome of diagnostic tests in growth retardation.
    The Journal of endocrinology, 2001, Volume: 171, Issue:2

    Topics: Acid Phosphatase; Adrenergic alpha-Agonists; Child; Clonidine; Female; Genotype; Growth Disorders; G

2001
[Effects of clonidine++ administration in children with familial short stature and retarded body growth].
    Boletin medico del Hospital Infantil de Mexico, 1992, Volume: 49, Issue:7

    Topics: Body Height; Child; Child, Preschool; Clonidine; Female; Growth Disorders; Humans; Male

1992
Growth hormone release during insulin tolerance, clonidine, arginine and growth hormone releasing hormone tests in short normal children and adolescents.
    Journal of endocrinological investigation, 1992, Volume: 15, Issue:2

    Topics: Adolescent; Arginine; Child; Child, Preschool; Clonidine; Female; Growth Disorders; Growth Hormone;

1992
Long-term treatment with growth hormone of children with short stature and normal growth hormone secretion.
    The Journal of pediatrics, 1992, Volume: 120, Issue:5

    Topics: Age Determination by Skeleton; Body Height; Child; Clonidine; Female; Growth Disorders; Growth Hormo

1992
Reliability of stimulated and spontaneous growth hormone (GH) levels for identifying the child with low GH secretion.
    The Journal of clinical endocrinology and metabolism, 1991, Volume: 72, Issue:3

    Topics: Adolescent; Child; Child, Preschool; Clonidine; Female; Growth Disorders; Humans; Levodopa; Male; Re

1991
[5 years' ambulatory care experience with the clonidine stimulation test].
    Ceskoslovenska pediatrie, 1991, Volume: 46, Issue:12

    Topics: Child; Clonidine; Growth Disorders; Growth Hormone; Humans

1991
Chronic growth hormone administration does not suppress endogenous growth hormone secretion in patients with neurosecretory growth hormone dysfunction.
    Hormone research, 1991, Volume: 35, Issue:3-4

    Topics: Age Determination by Skeleton; Body Height; Body Mass Index; Child; Clonidine; Female; Gonadotropin-

1991
Association of pharmacological tests and study of 24-hour growth hormone secretion in the investigation of growth retardation in children: analysis of 257 cases.
    Hormone research, 1991, Volume: 35, Issue:2

    Topics: Arginine; Betaxolol; Child; Clonidine; Female; Glucagon; Growth Disorders; Growth Hormone; Growth Ho

1991
Seasonal variation in growth during growth hormone therapy.
    American journal of diseases of children (1960), 1991, Volume: 145, Issue:7

    Topics: Adolescent; Child; Clonidine; Female; Growth; Growth Disorders; Growth Hormone; Humans; Insulin-Like

1991
One year treatment with clonidine in children with constitutional growth delay.
    Journal of endocrinological investigation, 1991, Volume: 14, Issue:2

    Topics: Adolescent; Child; Clonidine; Female; Growth Disorders; Growth Hormone; Humans; Male; Radioimmunoass

1991
Reproducibility of growth hormone testing procedures: a comparison between 24-hour integrated concentration and pharmacological stimulation.
    The Journal of clinical endocrinology and metabolism, 1990, Volume: 71, Issue:5

    Topics: Adolescent; Arginine; Child; Child, Preschool; Circadian Rhythm; Clonidine; Female; Growth Disorders

1990
[Treatment of children of short stature].
    Anales espanoles de pediatria, 1990, Volume: 33 Suppl 41

    Topics: Child; Clonidine; Growth Disorders; Growth Hormone; Humans; Propranolol

1990
Blunted growth hormone responses to clonidine in adolescent girls with early anorexia nervosa. Evidence for an early hypothalamic defect.
    Journal of adolescent health care : official publication of the Society for Adolescent Medicine, 1990, Volume: 11, Issue:2

    Topics: Adolescent; Adult; Anorexia Nervosa; Child; Clonidine; Female; Growth Disorders; Growth Hormone; Hum

1990
The effects of galanin on growth hormone secretion in children of normal and short stature.
    Pediatric research, 1989, Volume: 26, Issue:4

    Topics: Adolescent; Child; Child, Preschool; Clonidine; Female; Galanin; Growth Disorders; Growth Hormone; G

1989
Clonidine for short stature.
    Lancet (London, England), 1989, Mar-04, Volume: 1, Issue:8636

    Topics: Adult; Body Height; Child; Clonidine; Growth Disorders; Growth Hormone; Humans

1989
Clonidine for short stature.
    Lancet (London, England), 1989, Jun-17, Volume: 1, Issue:8651

    Topics: Body Height; Child; Clonidine; Drug Evaluation; Growth Disorders; Humans

1989
Growth hormone secretory profiles: variation on consecutive nights.
    The Journal of pediatrics, 1989, Volume: 115, Issue:1

    Topics: Adolescent; Child; Child, Preschool; Circadian Rhythm; Clonidine; Growth Disorders; Growth Hormone;

1989
[Side-effects of the clonidine test in 20 children with short stature].
    Anales espanoles de pediatria, 1989, Volume: 31, Issue:1

    Topics: Adolescent; Child; Child, Preschool; Clonidine; Female; Growth Disorders; Growth Hormone; Heart Rate

1989
Clonidine accelerates growth in children with impaired growth hormone secretion.
    Lancet (London, England), 1985, Jun-29, Volume: 1, Issue:8444

    Topics: Child; Clonidine; Female; Growth Disorders; Growth Hormone; Growth Hormone-Releasing Hormone; Humans

1985
Neurotransmitter administration and manipulation of growth.
    The Journal of pediatrics, 1986, Volume: 109, Issue:5

    Topics: Clonidine; Growth Disorders; Growth Hormone; Humans; Insulin-Like Growth Factor I; Neurotransmitter

1986
Clonidine for short stature.
    Lancet (London, England), 1988, Nov-19, Volume: 2, Issue:8621

    Topics: Age Factors; Body Height; Child; Clonidine; Female; Growth; Growth Disorders; Humans; Male

1988
Augmentation of growth hormone secretion in children with constitutional growth delay by short term clonidine administration: a pulse amplitude-modulated phenomenon.
    The Journal of clinical endocrinology and metabolism, 1989, Volume: 68, Issue:2

    Topics: Body Height; Child; Clonidine; Drug Administration Schedule; Female; Growth Disorders; Growth Hormon

1989
Preservation of dopaminergic and alpha-adrenergic function in children with growth hormone neurosecretory dysfunction.
    The Journal of clinical endocrinology and metabolism, 1986, Volume: 63, Issue:4

    Topics: Adolescent; Arginine; Child; Clonidine; Dopamine; Female; Growth Disorders; Growth Hormone; Growth H

1986
Effect of prolonged clonidine administration on growth hormone concentrations and rate of linear growth in children with constitutional growth delay.
    The Journal of pediatrics, 1986, Volume: 109, Issue:5

    Topics: Administration, Oral; Age Determination by Skeleton; Blood Pressure; Child; Clonidine; Female; Growt

1986
Comparison of growth hormone responses to classical stimulation tests and to intravenous administration of growth hormone releasing factor (GRF 1-44) in children with growth hormone deficiency.
    Endokrynologia Polska, 1987, Volume: 38, Issue:1

    Topics: Adolescent; Child; Child, Preschool; Clonidine; Female; Growth Disorders; Growth Hormone; Growth Hor

1987
Evaluation of growth hormone secretion: provocative testing vs endogenous 24-hour growth hormone profile.
    Acta paediatrica Scandinavica. Supplement, 1987, Volume: 337

    Topics: Adolescent; Arginine; Child; Clonidine; Female; Growth Disorders; Growth Hormone; Growth Hormone-Rel

1987
[Personal experience with the clonidine test for acute growth hormone stimulation].
    Ceskoslovenska pediatrie, 1988, Volume: 43, Issue:11

    Topics: Child; Clonidine; Growth Disorders; Growth Hormone; Humans

1988
Low-dose oral clonidine: effective growth hormone releasing agent in children but not in adolescents.
    The Journal of pediatrics, 1987, Volume: 111, Issue:4

    Topics: Adolescent; Adult; Blood Glucose; Child; Child, Preschool; Clonidine; Female; Growth Disorders; Grow

1987
[Comparison of nyctohemeral somatotropin secretion and response to pharmacological tests in 38 children with growth retardation].
    Archives francaises de pediatrie, 1987, Volume: 44, Issue:8

    Topics: Adolescent; Betaxolol; Child; Child, Preschool; Circadian Rhythm; Clonidine; Dwarfism; Female; Gluca

1987
Comparison of pharmacological tests and 24-hour growth hormone secretion in 130 children with delayed growth.
    Acta paediatrica Scandinavica. Supplement, 1987, Volume: 337

    Topics: Betaxolol; Child; Clonidine; Female; Glucagon; Growth Disorders; Growth Hormone; Humans; Male; Pitui

1987
[Efficacy of the clonidine test in the evaluation of growth hormone secretion in childhood and comparison with the insulin test].
    Minerva pediatrica, 1986, May-15, Volume: 38, Issue:9

    Topics: Adolescent; Child; Child, Preschool; Clonidine; Female; Growth Disorders; Growth Hormone; Humans; In

1986
Growth hormone (GH) provocative testing frequently does not reflect endogenous GH secretion.
    The Journal of clinical endocrinology and metabolism, 1986, Volume: 63, Issue:3

    Topics: Adolescent; Adult; Arginine; Child; Child, Preschool; Circadian Rhythm; Clonidine; Female; Growth Di

1986
Growth hormone secretion in patients with constitutional delay of growth and pubertal development.
    The Journal of pediatrics, 1986, Volume: 109, Issue:5

    Topics: Adolescent; Blood Pressure; Child; Clonidine; Growth Disorders; Growth Hormone; Humans; Insulin-Like

1986
Do short children secrete insufficient growth hormone?
    Pediatrics, 1985, Volume: 76, Issue:3

    Topics: Adolescent; Adult; Arginine; Body Height; Child; Child, Preschool; Clonidine; Female; Growth Disorde

1985
Clonidine and insulin tests for growth hormone deficiency.
    Archives of disease in childhood, 1985, Volume: 60, Issue:4

    Topics: Child; Clonidine; Female; Growth Disorders; Growth Hormone; Humans; Hypotension

1985