clonidine has been researched along with Glaucoma in 107 studies
Clonidine: An imidazoline sympatholytic agent that stimulates ALPHA-2 ADRENERGIC RECEPTORS and central IMIDAZOLINE RECEPTORS. It is commonly used in the management of HYPERTENSION.
clonidine (amino form) : A clonidine that is 4,5-dihydro-1H-imidazol-2-amine in which one of the amino hydrogens is replaced by a 2,6-dichlorophenyl group.
Glaucoma: An ocular disease, occurring in many forms, having as its primary characteristics an unstable or a sustained increase in the intraocular pressure which the eye cannot withstand without damage to its structure or impairment of its function. The consequences of the increased pressure may be manifested in a variety of symptoms, depending upon type and severity, such as excavation of the optic disk, hardness of the eyeball, corneal anesthesia, reduced visual acuity, seeing of colored halos around lights, disturbed dark adaptation, visual field defects, and headaches. (Dictionary of Visual Science, 4th ed)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Topical apraclonidine hydrochloride 1% is effective for controlling the intraocular pressure (IOP) rise following argon laser trabeculoplasty (ALT)." | 9.08 | Apraclonidine 0.5% versus 1% for controlling intraocular pressure elevation after argon laser trabeculoplasty. ( Allingham, RR; Assalian, AA; Shields, MB; Threlkeld, AB, 1996) |
| "0% apraclonidine in preventing laser-induced intraocular pressure (IOP) elevation after trabeculoplasty, neodymium: YAG (Nd: YAG) iridotomy, and capsulotomy." | 9.08 | Apraclonidine and anterior segment laser surgery. Comparison of 0.5% versus 1.0% apraclonidine for prevention of postoperative intraocular pressure rise. ( Gieser, DK; Grewal, RK; Karalekas, DP; Krupin, T; McDaniel, DL; Rosenberg, LF; Ruderman, J; Siegfried, C; Williams, R, 1995) |
| "Apraclonidine effectively decreased large IOP elevations in glaucomatous eyes undergoing trabeculectomy combined with extracapsular cataract surgery." | 9.07 | Effect of topical apraclonidine on the frequency of intraocular pressure elevations after combined extracapsular cataract extraction and trabeculectomy. ( Robin, AL, 1993) |
| "Seventeen patients with glaucoma were given bilaterally a single drop of Isoglaucon (Clonidine hydrochloride) of various volume (15 microliters and 40 microliters) and various concentrations of the drug (0." | 9.07 | [Various clonidine drops in treatment of glaucoma]. ( Brozyna-Zyłka, B; Otrzonsek, D; Sobieraj, A; Szymański, A, 1992) |
| "The authors compared the additive intraocular pressure (IOP)-lowering effects of two different topical medications, apraclonidine hydrochloride and dipivefrin hydrochloride, when used in conjunction with timolol maleate." | 9.06 | Adjunctive glaucoma therapy. A comparison of apraclonidine to dipivefrin when added to timolol maleate. ( Morrison, JC; Robin, AL, 1989) |
| "25% solutions of clonidine hydrochloride by comparison with a 2% pilocarpine hydrochloride solution and placebo was carried out in a total of 21 patients with open-angle glaucoma, each of whom received a single drop of each preparation in the same glaucomatous eye on separate days." | 9.04 | Clonidine. Effects of a topically administered solution on intraocular pressure and blood pressure in open-angle glaucoma. ( Harrison, R; Kaufmann, CS, 1977) |
| "To determine the incidence of intraocular pressure (IOP) rise of varying degrees after laser peripheral iridotomy (LPI) in patients with and without glaucoma treated perioperatively with pilocarpine and apraclonidine." | 7.70 | The rarity of clinically significant rise in intraocular pressure after laser peripheral iridotomy with apraclonidine. ( Gangnon, R; Heatley, GA; Kaufman, PL; Lewis, R; Perkins, TW, 1998) |
| "Intraocular pressure (IOP) measurements were carried out before and 1, 2 and 3 h after a single drop of apraclonidine." | 7.69 | Efficacy of apraclonidine ophthalmic solution (Iopidine) in presumed silicon oil-induced glaucoma and primary open-angle glaucoma. ( Busche, S; Gramer, E; Kampik, A; Parsons, D, 1995) |
| "5% apraclonidine may be a useful adjunct to other antiglaucoma treatment modalities in dogs, but is unlikely to be effective as the sole agent in most forms of canine glaucoma." | 7.69 | Effects of topical administration of 0.5% apraclonidine on intraocular pressure, pupil size, and heart rate in clinically normal dogs. ( Miller, PE; Nelson, MJ; Rhaesa, SL, 1996) |
| "We retrospectively compared the incidence and level of postoperative intraocular pressure (IOP) spikes in 53 consecutive glaucoma patients undergoing Nd:YAG posterior capsulotomy (YPC) who received apraclonidine immediately postoperatively, with those occurring in 22 consecutive similar patients who did not receive apraclonidine." | 7.68 | The effect of apraclonidine on the intraocular pressure of glaucoma patients following Nd:YAG laser posterior capsulotomy. ( Cullom, RD; Schwartz, LW, 1993) |
| "We evaluated the ability of topical clonidine to suppress an acute rise in postoperative intraocular pressure (IOP) following Nd:YAG laser iridotomy." | 7.67 | The prevention of an acute rise in intraocular pressure following Q-switched Nd:YAG laser iridotomy with clonidine. ( Kitazawa, Y; Sugiyama, K; Taniguchi, T, 1989) |
| "We evaluated the effectiveness of topical apraclonidine (ALO 2145, p-amino clonidine hydrochloride) in suppressing an acute postoperative intraocular pressure (IOP) rise following Nd:YAG laser iridotomy." | 7.67 | Use of apraclonidine to reduce acute intraocular pressure rise following Q-switched Nd:YAG laser iridotomy. ( Kitazawa, Y; Sugiyama, K; Taniguchi, T, 1989) |
| "The peripheral and central neural actions of clonidine on normal and glaucomatous eyes have been investigated." | 7.66 | The peripheral and central neural actions of clonidine in normal and glaucomatous eyes. ( Krieglstein, GK; Langham, ME; Leydhecker, W, 1978) |
| "Intraocular pressure was measured by a masked observer, using Goldmann applanation tonometry, before and 1 hour after the treatment." | 6.69 | Apraclonidine 0.5% versus brimonidine 0.2% for the control of intraocular pressure elevation following anterior segment laser procedures. ( Assalian, A; Chevrier, RL; Duperré, J; Lesk, MR, 1999) |
| "In apraclonidine-treated eyes the IOP fell from a mean of 15." | 6.66 | Effectiveness of apraclonidine in preventing the rise in intraocular pressure after neodymium:YAG posterior capsulotomy. ( Brown, RH; Crandall, AS; Pollack, IP; Robin, AL; Stewart, RH; White, GL, 1988) |
| "Glaucoma is in most of cases initially treated with drugs, viz." | 6.40 | [Four new drugs for glaucoma: apraclonidine, brimonidine, dorzolamide and latanoprost]. ( Hoyng, PF; Rasker, MT, 1998) |
| "To determine the 1- and 3-hour changes in intraocular pressure after neodymium:yttrium-aluminum-garnet (Nd:YAG) capsulotomy in pseudophakic patients with glaucoma and to determine the effect of acetazolamide and apraclonidine on these changes." | 5.11 | Neodymium:yttrium-aluminum-garnet capsulotomy and intraocular pressure in pseudophakic patients with glaucoma. ( Barnes, EA; Behrend, M; Cahill, A; Kehoe, B; Murdoch, IE; Subramaniam, S, 2004) |
| "Topical apraclonidine hydrochloride 1% is effective for controlling the intraocular pressure (IOP) rise following argon laser trabeculoplasty (ALT)." | 5.08 | Apraclonidine 0.5% versus 1% for controlling intraocular pressure elevation after argon laser trabeculoplasty. ( Allingham, RR; Assalian, AA; Shields, MB; Threlkeld, AB, 1996) |
| "0% apraclonidine in preventing laser-induced intraocular pressure (IOP) elevation after trabeculoplasty, neodymium: YAG (Nd: YAG) iridotomy, and capsulotomy." | 5.08 | Apraclonidine and anterior segment laser surgery. Comparison of 0.5% versus 1.0% apraclonidine for prevention of postoperative intraocular pressure rise. ( Gieser, DK; Grewal, RK; Karalekas, DP; Krupin, T; McDaniel, DL; Rosenberg, LF; Ruderman, J; Siegfried, C; Williams, R, 1995) |
| "Eighteen glaucoma patients who developed allergy to apraclonidine were enrolled." | 5.08 | Lack of cross-reactive allergic response to brimonidine in patients with known apraclonidine allergy. ( Gordon, RN; Greenfield, DS; Lama, P; Liebmann, JM; Ritch, R, 1998) |
| "Apraclonidine effectively decreased large IOP elevations in glaucomatous eyes undergoing trabeculectomy combined with extracapsular cataract surgery." | 5.07 | Effect of topical apraclonidine on the frequency of intraocular pressure elevations after combined extracapsular cataract extraction and trabeculectomy. ( Robin, AL, 1993) |
| "Seventeen patients with glaucoma were given bilaterally a single drop of Isoglaucon (Clonidine hydrochloride) of various volume (15 microliters and 40 microliters) and various concentrations of the drug (0." | 5.07 | [Various clonidine drops in treatment of glaucoma]. ( Brozyna-Zyłka, B; Otrzonsek, D; Sobieraj, A; Szymański, A, 1992) |
| "The authors compared the additive intraocular pressure (IOP)-lowering effects of two different topical medications, apraclonidine hydrochloride and dipivefrin hydrochloride, when used in conjunction with timolol maleate." | 5.06 | Adjunctive glaucoma therapy. A comparison of apraclonidine to dipivefrin when added to timolol maleate. ( Morrison, JC; Robin, AL, 1989) |
| "We performed a double-masked, cross-over, dose-response study of apraclonidine hydrochloride (formerly known as ALO 2145) in 20 patients with elevated intraocular pressure (IOP)." | 5.06 | Apraclonidine. A one-week dose-response study. ( Jampel, HD; Pollack, IP; Quigley, HA; Robin, AL, 1988) |
| "25% solutions of clonidine hydrochloride by comparison with a 2% pilocarpine hydrochloride solution and placebo was carried out in a total of 21 patients with open-angle glaucoma, each of whom received a single drop of each preparation in the same glaucomatous eye on separate days." | 5.04 | Clonidine. Effects of a topically administered solution on intraocular pressure and blood pressure in open-angle glaucoma. ( Harrison, R; Kaufmann, CS, 1977) |
| "This article reviews standard treatment modalities for patients with glaucoma and describes 3 classes of drugs which are undergoing development: apraclonidine (aplonidine, ALO 2145), an alpha 2-adrenergic agonist which has been released for clinical use; topical carbonic anhydrase inhibitors, a modification of the systemic carbonic anhydrase inhibitors currently in use; and prostaglandins (PGs), a new class of drugs with topical ocular hypotensive activity." | 4.78 | New developments in the drug treatment of glaucoma. ( Crawford, K; Hurvitz, LM; Kaufman, PL; Robin, AL; Shaw, B; Weinreb, RN, 1991) |
| "A summary is given of the common methods of treating glaucoma medically, beginning with the introduction of pilocarpine over 100 years ago and ending, for the time being, with the application of the beta-blocker Timolol Maleat (Chibro-Timoptol)." | 4.76 | [Report on the application of chibro-timoptol after one year's use in ophthalmological practice (author's transl)]. ( Gross, G; Täumer, R, 1980) |
| "To determine the incidence of intraocular pressure (IOP) rise of varying degrees after laser peripheral iridotomy (LPI) in patients with and without glaucoma treated perioperatively with pilocarpine and apraclonidine." | 3.70 | The rarity of clinically significant rise in intraocular pressure after laser peripheral iridotomy with apraclonidine. ( Gangnon, R; Heatley, GA; Kaufman, PL; Lewis, R; Perkins, TW, 1998) |
| "5% apraclonidine may be a useful adjunct to other antiglaucoma treatment modalities in dogs, but is unlikely to be effective as the sole agent in most forms of canine glaucoma." | 3.69 | Effects of topical administration of 0.5% apraclonidine on intraocular pressure, pupil size, and heart rate in clinically normal dogs. ( Miller, PE; Nelson, MJ; Rhaesa, SL, 1996) |
| "We undertook a retrospective analysis of 64 patients receiving long-term 1% apraclonidine therapy at the University of California-San Francisco Glaucoma Service." | 3.69 | Clinical experience with the long-term use of 1% apraclonidine. Incidence of allergic reactions. ( Alvarado, J; Butler, P; Hwang, I; Lin, S; Mannschreck, M, 1995) |
| "Intraocular pressure (IOP) measurements were carried out before and 1, 2 and 3 h after a single drop of apraclonidine." | 3.69 | Efficacy of apraclonidine ophthalmic solution (Iopidine) in presumed silicon oil-induced glaucoma and primary open-angle glaucoma. ( Busche, S; Gramer, E; Kampik, A; Parsons, D, 1995) |
| "We retrospectively compared the incidence and level of postoperative intraocular pressure (IOP) spikes in 53 consecutive glaucoma patients undergoing Nd:YAG posterior capsulotomy (YPC) who received apraclonidine immediately postoperatively, with those occurring in 22 consecutive similar patients who did not receive apraclonidine." | 3.68 | The effect of apraclonidine on the intraocular pressure of glaucoma patients following Nd:YAG laser posterior capsulotomy. ( Cullom, RD; Schwartz, LW, 1993) |
| "We evaluated the effectiveness of topical apraclonidine (ALO 2145, p-amino clonidine hydrochloride) in suppressing an acute postoperative intraocular pressure (IOP) rise following Nd:YAG laser iridotomy." | 3.67 | Use of apraclonidine to reduce acute intraocular pressure rise following Q-switched Nd:YAG laser iridotomy. ( Kitazawa, Y; Sugiyama, K; Taniguchi, T, 1989) |
| "We evaluated the ability of topical clonidine to suppress an acute rise in postoperative intraocular pressure (IOP) following Nd:YAG laser iridotomy." | 3.67 | The prevention of an acute rise in intraocular pressure following Q-switched Nd:YAG laser iridotomy with clonidine. ( Kitazawa, Y; Sugiyama, K; Taniguchi, T, 1989) |
| "The effect of topically applied clonidine on aphthalmic arterial pressure was tested in three groups of open-angle glaucoma patients." | 3.66 | The response of ophthalmic arterial pressure to topically applied clonidine. ( Gramer, E; Krieglstein, GK, 1978) |
| "The peripheral and central neural actions of clonidine on normal and glaucomatous eyes have been investigated." | 3.66 | The peripheral and central neural actions of clonidine in normal and glaucomatous eyes. ( Krieglstein, GK; Langham, ME; Leydhecker, W, 1978) |
| "Experience obtained in the treatment of 78 eyes of patients suffering from open-angle glaucoma with the beta-blocker Timolol 0." | 3.66 | [Experience with timolol in consulting patients (author's transl)]. ( Junker, C; Junker, H, 1980) |
| "Intraocular pressure was measured by a masked observer, using Goldmann applanation tonometry, before and 1 hour after the treatment." | 2.69 | Apraclonidine 0.5% versus brimonidine 0.2% for the control of intraocular pressure elevation following anterior segment laser procedures. ( Assalian, A; Chevrier, RL; Duperré, J; Lesk, MR, 1999) |
| "In apraclonidine-treated eyes the IOP fell from a mean of 15." | 2.66 | Effectiveness of apraclonidine in preventing the rise in intraocular pressure after neodymium:YAG posterior capsulotomy. ( Brown, RH; Crandall, AS; Pollack, IP; Robin, AL; Stewart, RH; White, GL, 1988) |
| "Glaucoma is in most of cases initially treated with drugs, viz." | 2.40 | [Four new drugs for glaucoma: apraclonidine, brimonidine, dorzolamide and latanoprost]. ( Hoyng, PF; Rasker, MT, 1998) |
| " Apraclonidine is well tolerated systemically with no serious adverse event attributed previously to this medicine." | 2.39 | [Effect and side effects of apraclonidine]. ( Stewart, WC, 1996) |
| "Glaucoma is a potentially blinding disease." | 2.39 | Pharmacological advances in the treatment of glaucoma. ( Serle, JB, 1994) |
| "The aim of all treatment for glaucoma is to lower intra-ocular pressure." | 2.38 | [Pharmacology aspects of glaucoma]. ( Alm, A; Berggren, L, 1992) |
| "Glaucomatous optic neuropathy is the consequence of progressive loss of the retinal ganglion cells whose axons comprise the optic nerve." | 1.31 | [Glaucoma as primary optic neuropathy]. ( Nicolae, A; Stefan, C, 2001) |
| "The author presents conservative treatment of glaucoma." | 1.28 | [Conservative treatment of glaucoma]. ( Tost, M, 1989) |
| "The intraocular pressure was well controlled in 9 of these, and sufficiently lowered in the remaining two." | 1.26 | [Treatment results with isoglaucon eye drops in sympatheticotone patients with early appearing primary glaucoma (author's transl)]. ( Marquardt, R, 1977) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 63 (58.88) | 18.7374 |
| 1990's | 33 (30.84) | 18.2507 |
| 2000's | 9 (8.41) | 29.6817 |
| 2010's | 2 (1.87) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Huber, D | 1 |
| Ehrhardt, JD | 1 |
| Decker, N | 1 |
| Himber, J | 1 |
| Andermann, G | 1 |
| Leclerc, G | 1 |
| Prokosch, V | 1 |
| Panagis, L | 1 |
| Volk, GF | 1 |
| Dermon, C | 1 |
| Thanos, S | 1 |
| Anton, A | 1 |
| Jordan, J | 1 |
| Lin, JC | 1 |
| Samuel, F | 1 |
| Katz, LJ | 2 |
| Spaeth, GL | 3 |
| Hoop, J | 1 |
| Cantor, LB | 1 |
| Barnes, EA | 1 |
| Murdoch, IE | 1 |
| Subramaniam, S | 1 |
| Cahill, A | 1 |
| Kehoe, B | 1 |
| Behrend, M | 1 |
| Sii, F | 1 |
| Todd, B | 1 |
| Shah, P | 1 |
| Chiang, M | 1 |
| Krieglstein, GK | 4 |
| Reibaldi, A | 1 |
| Giummarra, C | 1 |
| Ciracì, G | 1 |
| Leydhecker, W | 4 |
| Hopkins, GA | 1 |
| Krejcí, L | 1 |
| Brozek, B | 1 |
| Shen, ZM | 1 |
| Täumer, R | 1 |
| Gross, G | 1 |
| Hodapp, E | 1 |
| Kolker, AE | 1 |
| Kass, MA | 1 |
| Goldberg, I | 1 |
| Becker, B | 1 |
| Gordon, M | 1 |
| Rozsíval, P | 3 |
| Hrochová, J | 3 |
| Rehák, S | 3 |
| Junker, C | 1 |
| Junker, H | 1 |
| Feibel, RM | 1 |
| Gramer, E | 2 |
| Busche, S | 1 |
| Kampik, A | 1 |
| Parsons, D | 1 |
| Serle, JB | 1 |
| Butler, P | 1 |
| Mannschreck, M | 1 |
| Lin, S | 1 |
| Hwang, I | 1 |
| Alvarado, J | 1 |
| Cullom, RD | 1 |
| Schwartz, LW | 1 |
| Robin, AL | 6 |
| Pfeiffer, N | 2 |
| Araujo, SV | 2 |
| Bond, JB | 1 |
| Wilson, RP | 1 |
| Moster, MR | 1 |
| Schmidt, CM | 1 |
| Miller, PE | 1 |
| Nelson, MJ | 1 |
| Rhaesa, SL | 1 |
| Azuara-Blanco, A | 1 |
| Lu, DW | 1 |
| Lesk, MR | 2 |
| Threlkeld, AB | 1 |
| Assalian, AA | 1 |
| Allingham, RR | 1 |
| Shields, MB | 2 |
| Stewart, WC | 1 |
| Rosenberg, LF | 1 |
| Krupin, T | 1 |
| Ruderman, J | 1 |
| McDaniel, DL | 1 |
| Siegfried, C | 1 |
| Karalekas, DP | 1 |
| Grewal, RK | 1 |
| Gieser, DK | 1 |
| Williams, R | 1 |
| Gross, RL | 2 |
| Pinyero, A | 1 |
| Orengo-Nania, S | 2 |
| Morrison, JC | 2 |
| Nylander, KB | 1 |
| Lauer, AK | 1 |
| Cepurna, WO | 1 |
| Johnson, E | 1 |
| Burnstein, Y | 1 |
| Shelton, K | 1 |
| Higginbotham, EJ | 1 |
| Crichton, AC | 1 |
| Gordon, RN | 1 |
| Liebmann, JM | 1 |
| Greenfield, DS | 1 |
| Lama, P | 1 |
| Ritch, R | 1 |
| Lewis, R | 1 |
| Perkins, TW | 1 |
| Gangnon, R | 1 |
| Kaufman, PL | 2 |
| Heatley, GA | 1 |
| Hoyng, PF | 1 |
| Rasker, MT | 1 |
| Gebhardt, DO | 1 |
| Chevrier, RL | 1 |
| Assalian, A | 1 |
| Duperré, J | 1 |
| Apătăchioae, I | 1 |
| Chiseliţă, D | 1 |
| Williams, GC | 1 |
| Silvestre, JF | 1 |
| Carnero, L | 1 |
| Ramón, R | 1 |
| Albares, MP | 1 |
| Botella, R | 1 |
| Hayasaka, Y | 1 |
| Hayasaka, S | 1 |
| Zhang, XY | 1 |
| Nagaki, Y | 1 |
| Willis, AM | 1 |
| Diehl, KA | 1 |
| Robbin, TE | 1 |
| Stîngu, C | 1 |
| Cristescu, A | 1 |
| Dărăban, C | 1 |
| Ioniţă, M | 1 |
| Serghiescu, S | 1 |
| Nicolae, A | 1 |
| Stefan, C | 1 |
| Bunin, AJ | 1 |
| Jakovlev, AA | 1 |
| Jermakova, VN | 1 |
| Konde, LA | 1 |
| Langham, ME | 1 |
| Ralli, R | 1 |
| Wood, RA | 1 |
| Stiegler, G | 1 |
| Tittarelli, R | 2 |
| Pirani, A | 1 |
| Casini, E | 1 |
| Palmerini, S | 1 |
| Valazzi, CM | 1 |
| Conrads, H | 2 |
| Busse, H | 1 |
| Jünemann, G | 3 |
| Lienert, F | 1 |
| Bill, A | 1 |
| Heilmann, K | 7 |
| Marquardt, R | 2 |
| Merté, HJ | 1 |
| Harrison, R | 1 |
| Kaufmann, CS | 1 |
| Bietti, GB | 1 |
| De Caro, G | 1 |
| Giraldi, JP | 1 |
| Romani, E | 1 |
| Szymański, A | 1 |
| Brozyna-Zyłka, B | 1 |
| Sobieraj, A | 1 |
| Otrzonsek, D | 1 |
| Ofner, S | 1 |
| Samples, JR | 1 |
| van Buskirk, EM | 1 |
| Alm, A | 1 |
| Berggren, L | 1 |
| Siegel, MJ | 1 |
| Camras, CB | 2 |
| Lustgarten, JS | 1 |
| Podos, SM | 2 |
| Allf, BE | 1 |
| Hurvitz, LM | 1 |
| Weinreb, RN | 1 |
| Crawford, K | 1 |
| Shaw, B | 1 |
| Ming, YZ | 1 |
| Tost, M | 1 |
| Wang, RF | 1 |
| Lee, KW | 1 |
| Bhuyan, KC | 1 |
| Bhuyan, DK | 1 |
| Pulido, JS | 1 |
| Mallick, KS | 1 |
| Sneed, SR | 1 |
| Blodi, CF | 1 |
| Kitazawa, Y | 2 |
| Taniguchi, T | 2 |
| Sugiyama, K | 2 |
| Pollack, IP | 2 |
| Brown, RH | 1 |
| Crandall, AS | 1 |
| Stewart, RH | 1 |
| White, GL | 1 |
| Jampel, HD | 1 |
| Quigley, HA | 1 |
| Rozniecki, J | 1 |
| Berkman, N | 1 |
| Jahnke, R | 1 |
| Thumm, HW | 1 |
| Sayegh, F | 1 |
| Hartmann, J | 1 |
| Weigelin, E | 1 |
| Billing, G | 1 |
| Scharnke, W | 1 |
| Honegger, H | 1 |
| Arndt, Y | 1 |
| Ehrich, W | 1 |
| Kölbl, I | 1 |
| Linnert, D | 1 |
| Hollwich, F | 1 |
| Eisfeld, M | 1 |
| Kuborn, JP | 1 |
| Hasslinger, C | 1 |
| Sartori, C | 1 |
| Edelhauser, E | 1 |
| Nemetz, U | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Randomized, Double-Masked, Active Controlled, Crossover Phase III Equivalence Study of Dorzolamide 2% Eye Drops Solution In Subjects With Open Angle Glaucoma Or Ocular Hypertension[NCT00878917] | Phase 3 | 32 participants (Actual) | Interventional | 2009-04-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
14 reviews available for clonidine and Glaucoma
| Article | Year |
|---|---|
[α-agonists in ophthalmology].
Topics: Adrenergic alpha-2 Receptor Agonists; Animals; Clonidine; Eye Diseases; Glaucoma; Humans; Neuroprote | 2011 |
Drug treatment of glaucoma.
Topics: Acetazolamide; Administration, Topical; Adrenergic beta-Antagonists; Bromocriptine; Clonidine; Drona | 1984 |
[Report on the application of chibro-timoptol after one year's use in ophthalmological practice (author's transl)].
Topics: Acetazolamide; Clonidine; Glaucoma; Humans; Pilocarpine; Propanolamines; Timolol | 1980 |
Pharmacological advances in the treatment of glaucoma.
Topics: Administration, Topical; Adrenergic alpha-Agonists; Brimonidine Tartrate; Carbonic Anhydrase Inhibit | 1994 |
[Review of glaucoma research].
Topics: Adrenergic alpha-Agonists; Carbonic Anhydrase Inhibitors; Clonidine; Glaucoma; Humans; Intraocular P | 1993 |
[Effect and side effects of apraclonidine].
Topics: Adrenergic alpha-Agonists; Clonidine; Drug Therapy, Combination; Glaucoma; Humans; Intraocular Press | 1996 |
[Four new drugs for glaucoma: apraclonidine, brimonidine, dorzolamide and latanoprost].
Topics: Administration, Oral; Administration, Topical; Adrenergic alpha-Agonists; Brimonidine Tartrate; Carb | 1998 |
[Alpha-2 adrenergic agonists in the treatment of glaucoma].
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-Agonists; Brimonidine Tartrate; Clonidine; Gl | 1999 |
Advances in topical glaucoma therapy.
Topics: Administration, Topical; Animals; Cat Diseases; Cats; Clonidine; Dog Diseases; Dogs; Glaucoma; Human | 2002 |
The therapeutic uses of clonidine.
Topics: Blood Pressure; Climacteric; Clonidine; Female; Glaucoma; Hemodynamics; Humans; Hypertension; Kidney | 1979 |
[New developments in drug therapy of glaucoma].
Topics: Adrenergic alpha-Agonists; Carbonic Anhydrase Inhibitors; Clonidine; Glaucoma; Humans; Intraocular P | 1992 |
[Pharmacology aspects of glaucoma].
Topics: Adrenergic alpha-Agonists; Adrenergic beta-Antagonists; Calcium Channel Blockers; Carbonic Anhydrase | 1992 |
New developments in the drug treatment of glaucoma.
Topics: Adrenergic alpha-Agonists; Carbonic Anhydrase Inhibitors; Clonidine; Glaucoma; Humans; Prostaglandin | 1991 |
Medical management of acute postoperative intraocular pressure rises associated with anterior segment ophthalmic laser surgery.
Topics: Anterior Eye Segment; Clonidine; Glaucoma; Humans; Intraocular Pressure; Iris; Laser Therapy; Trabec | 1990 |
18 trials available for clonidine and Glaucoma
| Article | Year |
|---|---|
The effect of topical glaucoma medications evaluated by perimetry.
Topics: Administration, Topical; Antihypertensive Agents; Betaxolol; Clonidine; Epinephrine; Glaucoma; Human | 2003 |
Neodymium:yttrium-aluminum-garnet capsulotomy and intraocular pressure in pseudophakic patients with glaucoma.
Topics: Acetazolamide; Administration, Oral; Administration, Topical; Adrenergic alpha-Agonists; Antihyperte | 2004 |
The effect of topical clonidine on intraocular pressure.
Topics: Adult; Aged; Clinical Trials as Topic; Clonidine; Double-Blind Method; Female; Glaucoma; Humans; Int | 1981 |
Effect of topical apraclonidine on the frequency of intraocular pressure elevations after combined extracapsular cataract extraction and trabeculectomy.
Topics: Adrenergic alpha-Agonists; Aged; Cataract Extraction; Clonidine; Double-Blind Method; Female; Glauco | 1993 |
Apraclonidine 0.5% versus 1% for controlling intraocular pressure elevation after argon laser trabeculoplasty.
Topics: Administration, Topical; Adrenergic alpha-Agonists; Clonidine; Follow-Up Studies; Glaucoma; Humans; | 1996 |
Apraclonidine and anterior segment laser surgery. Comparison of 0.5% versus 1.0% apraclonidine for prevention of postoperative intraocular pressure rise.
Topics: Adrenergic alpha-Agonists; Aged; Anterior Eye Segment; Clonidine; Double-Blind Method; Glaucoma; Hum | 1995 |
Lack of cross-reactive allergic response to brimonidine in patients with known apraclonidine allergy.
Topics: Adrenergic alpha-Agonists; Adult; Aged; Aged, 80 and over; Antihypertensive Agents; Brimonidine Tart | 1998 |
Apraclonidine 0.5% versus brimonidine 0.2% for the control of intraocular pressure elevation following anterior segment laser procedures.
Topics: Adrenergic alpha-Agonists; Adult; Aged; Aged, 80 and over; Anterior Eye Segment; Brimonidine Tartrat | 1999 |
[Observations on the treatment of glaucoma with clonidin (author's transl)].
Topics: Adult; Clinical Trials as Topic; Clonidine; Drug Evaluation; Fatigue; Glaucoma; Humans; Intraocular | 1976 |
[Clonidine as ointment (author's transl)].
Topics: Adult; Aged; Chronic Disease; Clinical Trials as Topic; Clonidine; Drug Evaluation; Female; Glaucoma | 1976 |
Clonidine. Effects of a topically administered solution on intraocular pressure and blood pressure in open-angle glaucoma.
Topics: Administration, Topical; Blood Pressure; Clonidine; Glaucoma; Humans; Intraocular Pressure; Pilocarp | 1977 |
[Various clonidine drops in treatment of glaucoma].
Topics: Aged; Clonidine; Double-Blind Method; Female; Glaucoma; Humans; Intraocular Pressure; Male; Middle A | 1992 |
Effect of flurbiprofen on the reduction of intraocular pressure after administration of 1% apraclonidine in patients with glaucoma.
Topics: Clonidine; Flurbiprofen; Glaucoma; Humans; Intraocular Pressure; Osmolar Concentration | 1992 |
Adjunctive glaucoma therapy. A comparison of apraclonidine to dipivefrin when added to timolol maleate.
Topics: Adult; Aged; Clinical Trials as Topic; Clonidine; Drug Therapy, Combination; Epinephrine; Eye Diseas | 1989 |
Effectiveness of apraclonidine in preventing the rise in intraocular pressure after neodymium:YAG posterior capsulotomy.
Topics: Administration, Topical; Aged; Clonidine; Female; Glaucoma; Humans; Intraocular Pressure; Laser Ther | 1988 |
Apraclonidine. A one-week dose-response study.
Topics: Administration, Topical; Adult; Aged; Clinical Trials as Topic; Clonidine; Dose-Response Relationshi | 1988 |
[Influence of clonidine on intraocular pressure and pupillary diameter].
Topics: Analysis of Variance; Chronic Disease; Clonidine; Glaucoma; Humans; Intraocular Pressure; Ophthalmic | 1972 |
[Studies on the effect of Catapresan on the intraocular pressure. 3].
Topics: Blood Pressure; Clonidine; Glaucoma; Humans; Intraocular Pressure; Ophthalmic Artery; Ophthalmodynam | 1972 |
75 other studies available for clonidine and Glaucoma
| Article | Year |
|---|---|
Synthesis and ocular antihypertensive activity of new imidazolidine derivatives containing a beta-blocking side chain.
Topics: Animals; Antihypertensive Agents; Glaucoma; Guinea Pigs; Hypertension; Imidazoles; Male; Muscle, Smo | 1991 |
Alpha2-adrenergic receptors and their core involvement in the process of axonal growth in retinal explants.
Topics: Adrenergic alpha-2 Receptor Agonists; Animals; Autoradiography; Axons; Brimonidine Tartrate; Clonidi | 2010 |
Reduction of anterior-segment vascularity with preoperative topical apraclonidine 1%.
Topics: Administration, Topical; Adrenergic alpha-Agonists; Anterior Eye Segment; Cataract Extraction; Cilia | 2006 |
[Therapy in chronic glaucoma].
Topics: Adrenergic beta-Antagonists; Adult; Carbonic Anhydrase Inhibitors; Clonidine; Glaucoma; Humans; Meth | 1980 |
[The effect of antiglaucoma drugs on the depth of the anterior chamber (I)].
Topics: Adult; Anterior Chamber; Carbachol; Clonidine; Glaucoma; Humans; Middle Aged; Miotics; Moxisylyte; P | 1982 |
[Common side-effects of glaucoma therapy].
Topics: Acetazolamide; Adrenal Cortex Hormones; Adrenergic beta-Antagonists; Clonidine; Epinephrine; Glaucom | 1982 |
Influence of antiglaucoma drugs on axonal transport in the optic nerve.
Topics: Adrenergic beta-Antagonists; Animals; Axonal Transport; Clonidine; Echothiophate Iodide; Epinephrine | 1983 |
[Clinical observations on reduction on intraocular pressure by clonidine solution (author's transl)].
Topics: Adolescent; Adult; Clonidine; Female; Glaucoma; Humans; Intraocular Pressure; Male; Middle Aged | 1980 |
[Isoglaucon--2 years of experience].
Topics: Clonidine; Female; Glaucoma; Humans; Male; Middle Aged | 1982 |
Experience with management of glaucomas by isoglaucon.
Topics: Clonidine; Female; Glaucoma; Humans; Intraocular Pressure; Male; Middle Aged; Visual Acuity; Visual | 1980 |
[Isoglaucon in the treatment of glaucoma].
Topics: Clonidine; Female; Glaucoma; Humans; Middle Aged | 1980 |
[Experience with timolol in consulting patients (author's transl)].
Topics: Clonidine; Drug Combinations; Glaucoma; Humans; Intraocular Pressure; Pilocarpine; Propanolamines; T | 1980 |
High incidence of topical allergic reactions to 1% apraclonidine.
Topics: Administration, Topical; Adrenergic alpha-Agonists; Clonidine; Drug Hypersensitivity; Glaucoma; Huma | 1995 |
Efficacy of apraclonidine ophthalmic solution (Iopidine) in presumed silicon oil-induced glaucoma and primary open-angle glaucoma.
Topics: Adolescent; Adrenergic alpha-Agonists; Adult; Aged; Aged, 80 and over; Clonidine; Drug Tolerance; Fe | 1995 |
Clinical experience with the long-term use of 1% apraclonidine. Incidence of allergic reactions.
Topics: Adrenergic alpha-Agonists; Aged; Clonidine; Drug Hypersensitivity; Female; Follow-Up Studies; Glauco | 1995 |
The effect of apraclonidine on the intraocular pressure of glaucoma patients following Nd:YAG laser posterior capsulotomy.
Topics: Adrenergic alpha-Agonists; Aged; Clonidine; Female; Glaucoma; Humans; Incidence; Intraocular Pressur | 1993 |
Long term effect of apraclonidine.
Topics: Adolescent; Adrenergic alpha-Antagonists; Adult; Aged; Aged, 80 and over; Clonidine; Female; Follow- | 1995 |
Effects of topical administration of 0.5% apraclonidine on intraocular pressure, pupil size, and heart rate in clinically normal dogs.
Topics: Administration, Topical; Adrenergic alpha-Agonists; Animals; Cats; Circadian Rhythm; Clonidine; Dog | 1996 |
Effects of apraclonidine on short-term outcome of glaucoma surgery.
Topics: Adrenergic alpha-Agonists; Aged; Clonidine; Female; Glaucoma; Humans; Intraocular Pressure; Male; Mi | 1996 |
Clinical experience with apraclonidine 0.5%.
Topics: Adolescent; Adrenergic alpha-Agonists; Adult; Aged; Aged, 80 and over; Child; Chronic Disease; Cloni | 1997 |
Glaucoma drops control intraocular pressure and protect optic nerves in a rat model of glaucoma.
Topics: Adrenergic alpha-Agonists; Adrenergic beta-Antagonists; Animals; Betaxolol; Clonidine; Disease Model | 1998 |
Glaucomatocyclitic crisis in a child.
Topics: Adolescent; Clonidine; Corneal Edema; Diagnosis, Differential; Drug Therapy, Combination; Glaucoma; | 1998 |
Update in glaucoma: the new pharmacotherapies. Brimonidine versus apraclonidine.
Topics: Adrenergic alpha-Agonists; Antihypertensive Agents; Brimonidine Tartrate; Clonidine; Glaucoma; Human | 1998 |
The rarity of clinically significant rise in intraocular pressure after laser peripheral iridotomy with apraclonidine.
Topics: Adrenergic alpha-Agonists; Adult; Aged; Aged, 80 and over; Chemotherapy, Adjuvant; Clonidine; Female | 1998 |
[Four new drugs for glaucoma: apraclonidine, brimonidine, dorzolamide and latanoprost].
Topics: Adrenergic alpha-Agonists; Brimonidine Tartrate; Carbonic Anhydrase Inhibitors; Clonidine; Drug Appr | 1999 |
Incidence of brimonidine allergy in patients previously allergic to apraclonidine.
Topics: Adolescent; Adrenergic alpha-Agonists; Adult; Aged; Aged, 80 and over; Brimonidine Tartrate; Clonidi | 2000 |
Allergic contact dermatitis from apraclonidine in eyedrops.
Topics: Adrenergic alpha-Agonists; Clonidine; Dermatitis, Allergic Contact; Facial Dermatoses; Glaucoma; Hum | 2001 |
Effects of topical antiglaucoma eye drops on prostaglandin E(2)-induced aqueous flare elevation in pigmented rabbits.
Topics: Administration, Topical; Adrenergic alpha-Agonists; Animals; Antihypertensive Agents; Aqueous Humor; | 2002 |
[Iopidine in the control of intraocular pressure after glaucoma laser treatment].
Topics: Adrenergic alpha-Agonists; Clonidine; Glaucoma; Humans; Intraocular Pressure; Laser Therapy; Postope | 2001 |
[Glaucoma as primary optic neuropathy].
Topics: Adrenergic beta-Antagonists; Clonidine; Drug Therapy, Combination; Epinephrine; Glaucoma; Humans; Op | 2001 |
[The influence of isoglaucon on the hydrodynamics and haemodynamics of the eye (author's transl)].
Topics: Animals; Aqueous Humor; Blood Pressure; Clonidine; Glaucoma; Hemodynamics; Humans; Hydrogen-Ion Conc | 1975 |
The peripheral and central neural actions of clonidine in normal and glaucomatous eyes.
Topics: Adrenergic alpha-Antagonists; Adult; Aged; Aqueous Humor; Blood Pressure; Brachial Artery; Central N | 1978 |
Clonidin effect on the intraocular pressure and eye circulation [proceedings].
Topics: Clonidine; Dose-Response Relationship, Drug; Eye; Follow-Up Studies; Glaucoma; Humans; Intraocular P | 1975 |
The response of ophthalmic arterial pressure to topically applied clonidine.
Topics: Blood Pressure; Chronic Disease; Clonidine; Glaucoma; Humans; Ophthalmic Artery | 1978 |
[Bupranolol eye-drops (Ophtorenin) in long-term therapy of glaucoma (author's transl)].
Topics: Acetazolamide; Adult; Aged; Bupranolol; Clonidine; Drug Combinations; Drug Tolerance; Female; Glauco | 1979 |
[Results of iridocycloretraction in the treatment of neovascular glaucoma].
Topics: Clonidine; Conjunctiva; Female; Glaucoma; Humans; Intraocular Pressure; Iris; Male; Middle Aged | 1979 |
[The effect of topical clonidine on intraocular pressure in patients with glaucoma].
Topics: Administration, Topical; Adult; Aged; Clonidine; Female; Glaucoma; Humans; Intraocular Pressure; Mal | 1979 |
[Sympathomimetic and sympatholytic drugs in the therapy of glaucoma (author's transl)].
Topics: Albuterol; Clonidine; Epinephrine; Glaucoma; Humans; Isoproterenol; Norepinephrine; Propranolol; Sym | 1977 |
The effect of topically applied clonidine on the episcleral and conjunctival venous pressure of glaucomatous eyes.
Topics: Administration, Topical; Clonidine; Conjunctiva; Glaucoma; Humans; Sclera; Venous Pressure | 1977 |
Ocular effects of clonidine in cats and monkeys (Macaca irus).
Topics: Animals; Aqueous Humor; Blood Pressure; Cats; Ciliary Body; Clonidine; Eye; Female; Glaucoma; Haplor | 1975 |
[Treatment results with isoglaucon eye drops in sympatheticotone patients with early appearing primary glaucoma (author's transl)].
Topics: Adult; Blood Pressure; Clonidine; Glaucoma; Humans; Intraocular Pressure; Male; Middle Aged; Sympath | 1977 |
[Approaches in medical treatment in glaucoma (author's transl)].
Topics: Acetazolamide; Antihypertensive Agents; Clonidine; Delayed-Action Preparations; Glaucoma; Guanethidi | 1977 |
[Recent aspects in the treatment of glaucoma].
Topics: Acetazolamide; Clonidine; Glaucoma; Humans; Intraocular Pressure | 1977 |
[Special indications for the use of soft contact lenses as a drug-release-system (author's transl)].
Topics: Alcohols; Antihypertensive Agents; Clonidine; Contact Lenses, Hydrophilic; Delayed-Action Preparatio | 1976 |
Letter: Aspects of clonidine therapy.
Topics: Blood Pressure; Clonidine; Glaucoma; Humans; Hypertension; Optic Nerve | 1976 |
Apraclonidine and argon laser trabeculoplasty.
Topics: Adrenergic alpha-Agonists; Clonidine; Glaucoma; Humans; Intraocular Pressure; Laser Therapy; Pilocar | 1992 |
Early intraocular pressure response to laser trabeculoplasty 180 degrees without apraclonidine versus 360 degrees with apraclonidine.
Topics: Adrenergic alpha-Agonists; Aged; Clonidine; Female; Glaucoma; Humans; Intraocular Pressure; Laser Th | 1991 |
[The ocular hypotensive effect and side reactions of domestic clonidine eyedrops].
Topics: Blood Pressure; Clonidine; Glaucoma; Humans; Intraocular Pressure; Ophthalmic Solutions | 1991 |
[Conservative treatment of glaucoma].
Topics: Acetazolamide; Clonidine; Drug Evaluation; Epinephrine; Glaucoma; Humans; Intraocular Pressure; Moxi | 1989 |
The role of prostaglandins in the para-aminoclonidine-induced reduction of intraocular pressure.
Topics: Administration, Topical; Animals; Aqueous Humor; Clonidine; Dinoprost; Dinoprostone; Disease Models, | 1989 |
Apraclonidine hydrochloride in vitreoretinal surgery.
Topics: Adult; Clonidine; Female; Glaucoma; Humans; Intraocular Pressure; Male; Middle Aged; Retina; Retinal | 1989 |
Use of apraclonidine to reduce acute intraocular pressure rise following Q-switched Nd:YAG laser iridotomy.
Topics: Aged; Clonidine; Female; Glaucoma; Gonioscopy; Humans; Intraocular Pressure; Iris; Laser Therapy; Ma | 1989 |
The prevention of an acute rise in intraocular pressure following Q-switched Nd:YAG laser iridotomy with clonidine.
Topics: Administration, Topical; Adult; Aged; Blood Pressure; Clonidine; Female; Glaucoma; Gonioscopy; Human | 1989 |
[Less known indications for the use of clonidine].
Topics: Alcohol Amnestic Disorder; Brain Diseases; Clonidine; Glaucoma; Humans; Migraine Disorders; Opioid-R | 1985 |
[Letter: Glaucoma and clonidine. A new therapeutic possibility].
Topics: Chronic Disease; Clonidine; Drug Tolerance; Follow-Up Studies; Glaucoma; Humans; Intraocular Pressur | 1974 |
[Intraocular pressure, blood pressure, and glaucoma damage. Comparative perimetric studies on the relationship between the increase of intraocular pressure, blood sedimentation, and visual-field disorders in primary glaucoma].
Topics: Acetazolamide; Adult; Aged; Analysis of Variance; Blood Pressure; Clonidine; Female; Glaucoma; Human | 1972 |
[Clonidin for the treatment of glaucoma in general ophthalmic practice].
Topics: Chronic Disease; Clonidine; Glaucoma; Humans; Hypotension; Male; Professional Practice; Vertigo | 1973 |
[The influence of clonidin (isoglaucon) eyedrops on blood pressure, intraocular pressure and cerebral blood flow in healthy persons, hypertonic and glaucoma patients (author's transl)].
Topics: Administration, Topical; Arterial Occlusive Diseases; Arteriosclerosis; Blood Pressure; Cerebrovascu | 1973 |
Proceedings: Intraocular pressure, blood pressure and the optic nerve.
Topics: Blood Pressure; Clonidine; Glaucoma; Humans; Intraocular Pressure; Optic Nerve | 1973 |
[Trials with clonidine eyedrops in ophthalmologic practice].
Topics: Clonidine; Glaucoma; Humans | 1974 |
[Ambulatory treatment of glaucoma with clonidine in 25 patients].
Topics: Clonidine; Glaucoma; Humans | 1974 |
[Glaucoma therapy with local and general clonidine].
Topics: Clonidine; Glaucoma; Humans | 1974 |
[On the effect of clonidine on ocular and brachial pressure with normal intraocular pressure, with glaucoma simplex chronicum and with juvenile].
Topics: Blood Pressure; Clonidine; Glaucoma; Humans; Intraocular Pressure | 1974 |
[Clonidine in the so-called special forms of glaucoma].
Topics: Clonidine; Glaucoma; Humans | 1974 |
[Experiences with clonidine in hemorrhagic glaucoma in clinical practice].
Topics: Clonidine; Glaucoma; Hemorrhage; Humans | 1974 |
[Clonidine in glaucoma therapy].
Topics: Clonidine; Glaucoma; Humans; Intraocular Pressure; Time Factors | 1974 |
[Clonidine in glaucoma therapy--inferences for therapy and obvious problems].
Topics: Acetazolamide; Clonidine; Glaucoma; Humans | 1974 |
[Effect of clonidine on intraocular pressure in acute glaucoma].
Topics: Clonidine; Glaucoma; Humans; Intraocular Pressure | 1974 |
[Indications for clonidine in the treatment of glaucoma].
Topics: Clonidine; Glaucoma; Humans | 1974 |
[Clonidine in glaucoma treatment--results of a 2 and one-half year clinical study].
Topics: Clonidine; Glaucoma; Humans | 1974 |
[Results of clonidine in one eighth percent solution in hard glaucoma attacks in personal practice].
Topics: Clonidine; Glaucoma; Humans; Intraocular Pressure; Pupil | 1974 |
[Results with clonidine in a rural practice].
Topics: Clonidine; Germany, West; Glaucoma; Humans; Rural Health | 1974 |
[The use of clonidine in ophthalmologic practice].
Topics: Clonidine; Glaucoma; Humans | 1974 |
[Trial, over a period of several years, of the initial use of clonidine in primary glaucoma].
Topics: Clonidine; Glaucoma; Humans | 1974 |
[Lowering of intraocular pressure with clonidin].
Topics: Acetazolamide; Aged; Antihypertensive Agents; Blood Pressure; Clonidine; Drug Combinations; Glaucoma | 1972 |