clonidine and Glaucoma, Suspect studies

clonidine and Glaucoma, Suspect

clonidine has been researched along with Glaucoma, Suspect in 59 studies

Clonidine: An imidazoline sympatholytic agent that stimulates ALPHA-2 ADRENERGIC RECEPTORS and central IMIDAZOLINE RECEPTORS. It is commonly used in the management of HYPERTENSION.
clonidine (amino form) : A clonidine that is 4,5-dihydro-1H-imidazol-2-amine in which one of the amino hydrogens is replaced by a 2,6-dichlorophenyl group.

Research Excerpts

Excerpt	Relevance	Reference
"5% apraclonidine on Intraocular pressure (IOP) in horses and compare the effects of timolol maleate 0."	9.51	Effect of Topically Applied 0.5% Apraclonidine Versus 0.5% Timolol Maleate on Intraocular Pressure of Healthy Horses. ( Asghari, A; Ozmaie, S; Rajaei, SM; Ziadi, A, 2022)
"PRéCIS:: Adjuvant diclofenac and apraclonidine eye drop given in conjunction with selective laser trabeculoplasty (SLT) do not significantly impact medium-term intraocular pressure (IOP) reduction compared with placebo, but apraclonidine can be used to blunt immediate postlaser pressure spikes."	9.34	Effect of Apraclonidine and Diclofenac on Early Changes in Intraocular Pressure After Selective Laser Trabeculoplasty. ( Bergo, C; Halvorsen, H; Krohn, J; Thrane, AS; Thrane, VR, 2020)
"To evaluate the efficacy of preoperative oral clonidine (5 g/kg) in preventing ocular hypertension in the early period after cataract surgery with posterior chamber intraocular lens implantation under general anaesthesia."	9.16	Effect of oral clonidine on acute intraocular pressure rise after cataract extraction under general anaesthesia. ( Boroojeny, SB; Fard, MM, 2012)
"To determine the efficacy and safety of oral clonidine in decreasing the prevalence and intensity of postoperative intraocular pressure (IOP) rise in those undergoing phacoemulsification."	9.15	Effect of oral clonidine on acute intraocular pressure rise after phacoemulsification: a prospective double-blind, randomized, clinical trial. ( Boroojeny, SB; Fard, MM; Ghaffarpasand, F; Hourang, MH; Zakeri, H; Zeraatian, S, 2011)
"To evaluate the effectiveness of prophylactic topical apraclonidine 1% in preventing an intraocular pressure (IOP) rise in the early period after uneventful phacoemulsification with intraocular lens (IOL) implantation."	9.10	Preventing intraocular pressure increase after phacoemulsification and the role of perioperative apraclonidine. ( Desai, SP; Kasetti, SR; Sivakumar, S; Sunderraj, P, 2002)
"The authors compared the efficacy of apraclonidine 1% versus pilocarpine 4% prophylaxis of post-argon laser trabeculoplasty (ALT) intraocular pressure (IOP) spike."	9.09	Efficacy of apraclonidine 1% versus pilocarpine 4% for prophylaxis of intraocular pressure spike after argon laser trabeculoplasty. ( Birt, CM; Chung, HS; Glover, BK; Hughes, BA; Juzych, MS; Kim, C; Ren, J; Shin, DH, 1999)
"2% can control intraocular pressure (IOP) spikes as well as apraclonidine 1."	9.09	Control of intraocular pressure elevations after argon laser trabeculoplasty: comparison of brimonidine 0.2% to apraclonidine 1.0%. ( Barnes, SD; Campagna, JA; Dirks, MS; Doe, EA, 1999)
"Topical apraclonidine hydrochloride 1% is effective for controlling the intraocular pressure (IOP) rise following argon laser trabeculoplasty (ALT)."	9.08	Apraclonidine 0.5% versus 1% for controlling intraocular pressure elevation after argon laser trabeculoplasty. ( Allingham, RR; Assalian, AA; Shields, MB; Threlkeld, AB, 1996)
"0% apraclonidine in preventing laser-induced intraocular pressure (IOP) elevation after trabeculoplasty, neodymium: YAG (Nd: YAG) iridotomy, and capsulotomy."	9.08	Apraclonidine and anterior segment laser surgery. Comparison of 0.5% versus 1.0% apraclonidine for prevention of postoperative intraocular pressure rise. ( Gieser, DK; Grewal, RK; Karalekas, DP; Krupin, T; McDaniel, DL; Rosenberg, LF; Ruderman, J; Siegfried, C; Williams, R, 1995)
"To measure the effect of 1% apraclonidine hydrochloride eyedrops on intraocular pressure (IOP) after cataract surgery."	9.08	The effect of 1% apraclonidine on intraocular pressure after cataract surgery. ( Renzenbrink-Bubberman, AC; Sterk, CC; van Best, JA, 1998)
"To investigate if apraclonidine can effectively prevent the acute increase of intraocular pressure (IOP) in brown eyes with Nd:YAG laser iridectomy."	9.08	[Apraclonidine prevents the acute increase of intraocular pressure in brown eyes with Nd:YAG laser iridectomy]. ( Liu, X; Mao, J; Zhao, J, 1998)
"To evaluate the effect of topical apraclonidine on early postoperative intraocular pressure and blood-aqueous barrier permeability, we conducted a double-masked clinical trial in which 37 patients undergoing uncomplicated phacoemulsification and posterior chamber intraocular lens implantation were randomly assigned to treatment with 1% apraclonidine or its vehicle."	9.07	Effects of apraclonidine on intraocular pressure and blood-aqueous barrier permeability after phacoemulsification and intraocular lens implantation. ( Araie, M; Ishi, K, 1993)
"Apraclonidine effectively decreased large IOP elevations in glaucomatous eyes undergoing trabeculectomy combined with extracapsular cataract surgery."	9.07	Effect of topical apraclonidine on the frequency of intraocular pressure elevations after combined extracapsular cataract extraction and trabeculectomy. ( Robin, AL, 1993)
"The objective of the study was to assess the effects of premedication with clonidine on intraocular pressure (IOP) after the administration of succinylcholine."	9.07	Oral clonidine premedication prevents the rise in intraocular pressure following succinylcholine administration. ( Böhrer, H; Martin, E; Polarz, H; Völcker, HE; Wolfrum, J, 1993)
"0% apraclonidine hydrochloride in 15 normal volunteers and 17 subjects with increased intraocular pressure."	9.06	A limited comparison of apraclonidine's dose response in subjects with normal or increased intraocular pressure. ( Abrams, DA; Caldwell, DR; Crandall, AS; Pollack, IP; Rader, JE; Reaves, TA; Robin, AL; Schnitzer, DB, 1989)
"To determine the incidence of intraocular pressure (IOP) rise of varying degrees after laser peripheral iridotomy (LPI) in patients with and without glaucoma treated perioperatively with pilocarpine and apraclonidine."	7.70	The rarity of clinically significant rise in intraocular pressure after laser peripheral iridotomy with apraclonidine. ( Gangnon, R; Heatley, GA; Kaufman, PL; Lewis, R; Perkins, TW, 1998)
"We retrospectively compared the incidence and level of postoperative intraocular pressure (IOP) spikes in 53 consecutive glaucoma patients undergoing Nd:YAG posterior capsulotomy (YPC) who received apraclonidine immediately postoperatively, with those occurring in 22 consecutive similar patients who did not receive apraclonidine."	7.68	The effect of apraclonidine on the intraocular pressure of glaucoma patients following Nd:YAG laser posterior capsulotomy. ( Cullom, RD; Schwartz, LW, 1993)
"Alpha-chymotrypsin-induced ocular hypertension in albino rabbits is widely used as an experimental model to screen potential antiglaucoma drugs."	7.67	Effects of adrenergic agents on alpha-chymotrypsin-induced ocular hypertension in albino and pigmented rabbits: a comparative study. ( Andermann, G; de Burlet, G; Himber, J, 1989)
"We evaluated the effectiveness of topical apraclonidine (ALO 2145, p-amino clonidine hydrochloride) in suppressing an acute postoperative intraocular pressure (IOP) rise following Nd:YAG laser iridotomy."	7.67	Use of apraclonidine to reduce acute intraocular pressure rise following Q-switched Nd:YAG laser iridotomy. ( Kitazawa, Y; Sugiyama, K; Taniguchi, T, 1989)
"Intraocular pressure was measured by a masked observer, using Goldmann applanation tonometry, before and 1 hour after the treatment."	6.69	Apraclonidine 0.5% versus brimonidine 0.2% for the control of intraocular pressure elevation following anterior segment laser procedures. ( Assalian, A; Chevrier, RL; Duperré, J; Lesk, MR, 1999)
"5% apraclonidine on Intraocular pressure (IOP) in horses and compare the effects of timolol maleate 0."	5.51	Effect of Topically Applied 0.5% Apraclonidine Versus 0.5% Timolol Maleate on Intraocular Pressure of Healthy Horses. ( Asghari, A; Ozmaie, S; Rajaei, SM; Ziadi, A, 2022)
"PRéCIS:: Adjuvant diclofenac and apraclonidine eye drop given in conjunction with selective laser trabeculoplasty (SLT) do not significantly impact medium-term intraocular pressure (IOP) reduction compared with placebo, but apraclonidine can be used to blunt immediate postlaser pressure spikes."	5.34	Effect of Apraclonidine and Diclofenac on Early Changes in Intraocular Pressure After Selective Laser Trabeculoplasty. ( Bergo, C; Halvorsen, H; Krohn, J; Thrane, AS; Thrane, VR, 2020)
"To evaluate the efficacy of preoperative oral clonidine (5 g/kg) in preventing ocular hypertension in the early period after cataract surgery with posterior chamber intraocular lens implantation under general anaesthesia."	5.16	Effect of oral clonidine on acute intraocular pressure rise after cataract extraction under general anaesthesia. ( Boroojeny, SB; Fard, MM, 2012)
"05 mL of bevacizumab or ranibizumab), that were divided into five groups, group 1: no intraocular pressure (IOP)-lowering medication (n=50); group 2: apraclonidine 1 % one drop 2 hours prior to IVI (n=50); group 3: acetazolamide 250 mg 2 hours prior (n=50); group 4: fixed combination brimonidine+timolol (n=30); group 5: fixed combination dorzolamide+timolol (n=30)."	5.16	[Efficacy of prophylactic treatment of intraocular pressure spikes due to intravitreal injections]. ( Dot, C; El Chehab, H; Giraud, JM; Le Corre, A; Ract-Madoux, G; Swalduz, B, 2012)
"To determine the efficacy and safety of oral clonidine in decreasing the prevalence and intensity of postoperative intraocular pressure (IOP) rise in those undergoing phacoemulsification."	5.15	Effect of oral clonidine on acute intraocular pressure rise after phacoemulsification: a prospective double-blind, randomized, clinical trial. ( Boroojeny, SB; Fard, MM; Ghaffarpasand, F; Hourang, MH; Zakeri, H; Zeraatian, S, 2011)
"To evaluate the effectiveness of prophylactic topical apraclonidine 1% in preventing an intraocular pressure (IOP) rise in the early period after uneventful phacoemulsification with intraocular lens (IOL) implantation."	5.10	Preventing intraocular pressure increase after phacoemulsification and the role of perioperative apraclonidine. ( Desai, SP; Kasetti, SR; Sivakumar, S; Sunderraj, P, 2002)
"The authors compared the efficacy of apraclonidine 1% versus pilocarpine 4% prophylaxis of post-argon laser trabeculoplasty (ALT) intraocular pressure (IOP) spike."	5.09	Efficacy of apraclonidine 1% versus pilocarpine 4% for prophylaxis of intraocular pressure spike after argon laser trabeculoplasty. ( Birt, CM; Chung, HS; Glover, BK; Hughes, BA; Juzych, MS; Kim, C; Ren, J; Shin, DH, 1999)
"2% can control intraocular pressure (IOP) spikes as well as apraclonidine 1."	5.09	Control of intraocular pressure elevations after argon laser trabeculoplasty: comparison of brimonidine 0.2% to apraclonidine 1.0%. ( Barnes, SD; Campagna, JA; Dirks, MS; Doe, EA, 1999)
"0% apraclonidine in preventing laser-induced intraocular pressure (IOP) elevation after trabeculoplasty, neodymium: YAG (Nd: YAG) iridotomy, and capsulotomy."	5.08	Apraclonidine and anterior segment laser surgery. Comparison of 0.5% versus 1.0% apraclonidine for prevention of postoperative intraocular pressure rise. ( Gieser, DK; Grewal, RK; Karalekas, DP; Krupin, T; McDaniel, DL; Rosenberg, LF; Ruderman, J; Siegfried, C; Williams, R, 1995)
"Topical apraclonidine hydrochloride 1% is effective for controlling the intraocular pressure (IOP) rise following argon laser trabeculoplasty (ALT)."	5.08	Apraclonidine 0.5% versus 1% for controlling intraocular pressure elevation after argon laser trabeculoplasty. ( Allingham, RR; Assalian, AA; Shields, MB; Threlkeld, AB, 1996)
"The apraclonidine-induced reduction in intraocular pressure was associated with an increase in fluorophotometric outflow facility, decrease in aqueous flow and decrease in episcleral venous pressure compared to baseline."	5.08	Effects of apraclonidine on aqueous humor dynamics in human eyes. ( Camras, CB; Tafoya, ME; Toris, CB; Yablonski, ME, 1995)
"To investigate if apraclonidine can effectively prevent the acute increase of intraocular pressure (IOP) in brown eyes with Nd:YAG laser iridectomy."	5.08	[Apraclonidine prevents the acute increase of intraocular pressure in brown eyes with Nd:YAG laser iridectomy]. ( Liu, X; Mao, J; Zhao, J, 1998)
"To measure the effect of 1% apraclonidine hydrochloride eyedrops on intraocular pressure (IOP) after cataract surgery."	5.08	The effect of 1% apraclonidine on intraocular pressure after cataract surgery. ( Renzenbrink-Bubberman, AC; Sterk, CC; van Best, JA, 1998)
"Apraclonidine effectively lowers IOP associated with open-angle glaucoma or ocular hypertension; these pilot results will need to be confirmed by a larger pivotal study."	5.07	Comparison of apraclonidine and timolol in chronic open-angle glaucoma. A three-month study. ( Chuniaud, M; Demailly, P; Hitchings, RA; Nagasubramanian, S; Pannarale, MR; Parsons, DG; Pecori-Giraldi, J; Stodtmeister, R, 1993)
"The objective of the study was to assess the effects of premedication with clonidine on intraocular pressure (IOP) after the administration of succinylcholine."	5.07	Oral clonidine premedication prevents the rise in intraocular pressure following succinylcholine administration. ( Böhrer, H; Martin, E; Polarz, H; Völcker, HE; Wolfrum, J, 1993)
"To evaluate the effect of topical apraclonidine on early postoperative intraocular pressure and blood-aqueous barrier permeability, we conducted a double-masked clinical trial in which 37 patients undergoing uncomplicated phacoemulsification and posterior chamber intraocular lens implantation were randomly assigned to treatment with 1% apraclonidine or its vehicle."	5.07	Effects of apraclonidine on intraocular pressure and blood-aqueous barrier permeability after phacoemulsification and intraocular lens implantation. ( Araie, M; Ishi, K, 1993)
"Apraclonidine effectively decreased large IOP elevations in glaucomatous eyes undergoing trabeculectomy combined with extracapsular cataract surgery."	5.07	Effect of topical apraclonidine on the frequency of intraocular pressure elevations after combined extracapsular cataract extraction and trabeculectomy. ( Robin, AL, 1993)
"We performed a prospective, randomized double blind study comparing the cardiovascular and intraocular pressure (IOP) effects of unilateral therapy with clonidine 0."	5.07	Apraclonidine and clonidine: a comparison of efficacy and side effects in normal and ocular hypertensive volunteers. ( Caglar, Y; Elibol, O; Güler, C; Yüksel, N, 1992)
"The short-term additive effect and side effects of adding 1% apraclonidine hydrochloride to nonselective beta-blockers were investigated in 21 patients with ocular hypertension or early primary open-angle glaucoma."	5.07	Additive effect of 1% apraclonidine hydrochloride to nonselective beta-blockers. ( Lee, SH; Lee, SY; Parrow, KA; Shin, DH; Yaldo, MK, 1991)
"0% apraclonidine hydrochloride in 15 normal volunteers and 17 subjects with increased intraocular pressure."	5.06	A limited comparison of apraclonidine's dose response in subjects with normal or increased intraocular pressure. ( Abrams, DA; Caldwell, DR; Crandall, AS; Pollack, IP; Rader, JE; Reaves, TA; Robin, AL; Schnitzer, DB, 1989)
"The effect of an alpha adrenergic agonist, ALO 2145 (para-amino-clonidine [PAC]), was examined in a double-masked, multicenter study on the postoperative intraocular pressure (IOP) elevation after laser surgery in 165 patients (83 trabeculoplasty, 36 iridotomy, and 46 capsulotomy)."	5.06	ALO 2145 reduces the intraocular pressure elevation after anterior segment laser surgery. ( Brown, RH; Crandall, AS; DeFaller, JM; Gaasterland, DE; Higginbotham, EJ; Lynch, MG; Mandell, AI; Schwartz, AL; Stewart, RH; Wilensky, JT, 1988)
"To determine the incidence of intraocular pressure (IOP) rise of varying degrees after laser peripheral iridotomy (LPI) in patients with and without glaucoma treated perioperatively with pilocarpine and apraclonidine."	3.70	The rarity of clinically significant rise in intraocular pressure after laser peripheral iridotomy with apraclonidine. ( Gangnon, R; Heatley, GA; Kaufman, PL; Lewis, R; Perkins, TW, 1998)
"We retrospectively compared the incidence and level of postoperative intraocular pressure (IOP) spikes in 53 consecutive glaucoma patients undergoing Nd:YAG posterior capsulotomy (YPC) who received apraclonidine immediately postoperatively, with those occurring in 22 consecutive similar patients who did not receive apraclonidine."	3.68	The effect of apraclonidine on the intraocular pressure of glaucoma patients following Nd:YAG laser posterior capsulotomy. ( Cullom, RD; Schwartz, LW, 1993)
"We evaluated the effectiveness of topical apraclonidine (ALO 2145, p-amino clonidine hydrochloride) in suppressing an acute postoperative intraocular pressure (IOP) rise following Nd:YAG laser iridotomy."	3.67	Use of apraclonidine to reduce acute intraocular pressure rise following Q-switched Nd:YAG laser iridotomy. ( Kitazawa, Y; Sugiyama, K; Taniguchi, T, 1989)
"Alpha-chymotrypsin-induced ocular hypertension in albino rabbits is widely used as an experimental model to screen potential antiglaucoma drugs."	3.67	Effects of adrenergic agents on alpha-chymotrypsin-induced ocular hypertension in albino and pigmented rabbits: a comparative study. ( Andermann, G; de Burlet, G; Himber, J, 1989)
"Intraocular pressure was measured preoperatively and 4 to 6 and 24 hours postoperatively."	2.69	Medical control of intraocular pressure after cataract surgery. ( Byrd, S; Singh, K, 1998)
"Intraocular pressure was measured by a masked observer, using Goldmann applanation tonometry, before and 1 hour after the treatment."	2.69	Apraclonidine 0.5% versus brimonidine 0.2% for the control of intraocular pressure elevation following anterior segment laser procedures. ( Assalian, A; Chevrier, RL; Duperré, J; Lesk, MR, 1999)
"5% timolol 8 hours after dosing on days 1, 30, and 90; and a significant difference (P < ."	2.68	A 90-day study of the efficacy and side effects of 0.25% and 0.5% apraclonidine vs 0.5% timolol. Apraclonidine Primary Therapy Study Group. ( Horwitz, B; Kottler, M; Laibovitz, R; Ritch, R; Stewart, RH; Stewart, WC, 1996)
"5% timolol maleate twice daily for at least 4 weeks and who had 8 AM IOPs of at least 22 mm Hg and no greater than 30 mm Hg 12 hours after dosing were eligible for the study."	2.68	The efficacy of apraclonidine as an adjunct to timolol therapy. Apraclonidine Adjunctive Therapy Study Group. ( Lehmann, RP; Ritch, R; Shin, DH; Shrader, CE; Stewart, WC; van Buskirk, EM, 1995)
" ALO 2145 1% was shown to be effective and well tolerated in the dosage regimen employed in this study."	2.67	[Efficacy and tolerability of apraclonidine (ALO 2145, 1%) in the prevention of early ocular hypertonia, after trabeculoretraction using argon laser and posterior capsulotomy using Nd:YAG laser]. ( Berrod, JP; Raspiller, A, 1992)
"We document the recurrence of a CSMD in a patient subsequent to the instillation of topical ocular hypotensive medications and its resolution on discontinuation of therapy."	1.35	Recurrent serous macular detachment after topical ocular hypotensive medication. ( Besada, E; Frauens, BJ; Shechtman, D, 2008)

Research

Studies (59)

Timeframe	Studies, this research(%)	All Research%
pre-1990	7 (11.86)	18.7374
1990's	30 (50.85)	18.2507
2000's	13 (22.03)	29.6817
2010's	7 (11.86)	24.3611
2020's	2 (3.39)	2.80

Timeframe

Studies, this research(%)

All Research%

pre-1990

7 (11.86)

18.7374

1990's

30 (50.85)

18.2507

2000's

13 (22.03)

29.6817

2010's

7 (11.86)

24.3611

2020's

2 (3.39)

2.80

Authors

Authors	Studies
Ziadi, A	1
Ozmaie, S	1
Asghari, A	1
Rajaei, SM	1
Thrane, VR	1
Thrane, AS	1
Bergo, C	1
Halvorsen, H	1
Krohn, J	1
Boroojeny, SB	2
Fard, MM	2
Celik, E	1
Turkoglu, EB	1
Altun, G	1
Alagoz, G	1
Oatts, JT	1
Wang, X	1
Loewen, NA	1
Zhang, L	1
Weizer, JS	1
Musch, DC	1
Besada, E	1
Shechtman, D	1
Frauens, BJ	1
Zeraatian, S	1
Zakeri, H	1
Hourang, MH	1
Ghaffarpasand, F	1
El Chehab, H	1
Le Corre, A	1
Giraud, JM	1
Ract-Madoux, G	1
Swalduz, B	1
Dot, C	1
Kasetti, SR	1
Desai, SP	1
Sivakumar, S	1
Sunderraj, P	1
Arieta, C	1
Amaral, M	1
Matuda, E	1
Crosta, C	1
de Carvalho Moreira Filho, D	1
José, N	1
Chen, TC	2
Unal, M	1
Yücel, I	1
Akar, Y	1
Scuderi, G	1
Regine, F	1
Perdicchi, A	1
Mannino, G	1
Recupero, SM	1
Kotecha, A	1
Elsheikh, A	1
Roberts, CR	1
Zhu, H	1
Garway-Heath, DF	1
Robin, AL	5
Feist, RM	1
Palmer, DJ	1
Fiscella, R	1
Ernest, JT	1
Tripathi, R	1
Torczynski, E	1
Farber, M	1
Hu, YZ	1
Wei, HR	1
Stewart, WC	2
Ritch, R	2
Shin, DH	4
Lehmann, RP	1
Shrader, CE	1
van Buskirk, EM	1
Toris, CB	1
Tafoya, ME	1
Camras, CB	1
Yablonski, ME	1
Bömer, TG	1
Lagrèze, WD	1
Funk, J	1
Hong, C	1
Song, KY	1
Cullom, RD	1
Schwartz, LW	1
Araie, M	1
Ishi, K	1
Nagasubramanian, S	1
Hitchings, RA	1
Demailly, P	1
Chuniaud, M	1
Pannarale, MR	1
Pecori-Giraldi, J	1
Stodtmeister, R	1
Parsons, DG	1
Polarz, H	1
Böhrer, H	1
Martin, E	1
Wolfrum, J	1
Völcker, HE	1
Birt, CM	2
Reed, SY	1
McCarty, B	1
Kim, C	2
Frenkel, RE	1
Núñez, M	1
Figueira, A	1
Guerra, V	1
Baños, G	1
Alvarez, ML	1
Rodríguez, M	1
Laibovitz, R	1
Horwitz, B	1
Stewart, RH	2
Kottler, M	1
Threlkeld, AB	1
Assalian, AA	1
Allingham, RR	1
Shields, MB	1
Rosenberg, LF	1
Krupin, T	1
Ruderman, J	1
McDaniel, DL	1
Siegfried, C	1
Karalekas, DP	1
Grewal, RK	1
Gieser, DK	1
Williams, R	1
Morrison, JC	2
Nylander, KB	1
Lauer, AK	1
Cepurna, WO	1
Johnson, E	1
Sterk, CC	1
Renzenbrink-Bubberman, AC	1
van Best, JA	1
Byrd, S	1
Singh, K	1
Lewis, R	1
Perkins, TW	1
Gangnon, R	1
Kaufman, PL	1
Heatley, GA	1
Chevrier, RL	1
Assalian, A	1
Duperré, J	1
Lesk, MR	1
Ren, J	1
Chung, HS	1
Glover, BK	1
Juzych, MS	1
Hughes, BA	1
Barnes, SD	1
Campagna, JA	1
Dirks, MS	1
Doe, EA	1
Chakraborty, P	1
Villada, JR	1
Tinu, A	1
Mittra, RA	1
Pollack, JS	1
Dev, S	1
Han, DP	1
Mieler, WF	1
Pulido, JS	1
Connor, TB	1
Lacheretz, F	1
Barbier, A	1
Serradeil-Le Gal, C	1
Elena, PP	1
Maffrand, JP	1
Le Fur, G	1
Rainer, G	1
Menapace, R	1
Findl, O	1
Georgopoulos, M	1
Kiss, B	1
Heinze, G	1
Sciscio, A	1
Casswell, AG	1
Ang, RT	1
Grosskreutz, CL	1
Pasquale, LR	1
Fan, JT	1
Zhao, J	1
Mao, J	1
Liu, X	1
Romanowski, A	1
Prata Júnior, JA	1
Rehder, JR	1
Mello, PA	1
Yüksel, N	1
Güler, C	1
Caglar, Y	1
Elibol, O	1
Raspiller, A	1
Berrod, JP	1
Yaldo, MK	1
Parrow, KA	1
Lee, SH	1
Lee, SY	1
Himber, J	1
de Burlet, G	1
Andermann, G	1
Kitazawa, Y	1
Taniguchi, T	1
Sugiyama, K	1
Jampel, HD	1
Abrams, DA	1
Crandall, AS	2
Caldwell, DR	1
Schnitzer, DB	1
Pollack, IP	2
Rader, JE	1
Reaves, TA	1
Dandona, L	1
Quigley, HA	1
House, B	1
Enger, C	1
Brown, RH	1
Lynch, MG	1
Mandell, AI	1
Wilensky, JT	1
Schwartz, AL	1
Gaasterland, DE	1
DeFaller, JM	1
Higginbotham, EJ	1

Studies

Ziadi, A

Ozmaie, S

Asghari, A

Rajaei, SM

Thrane, VR

Thrane, AS

Bergo, C

Halvorsen, H

Krohn, J

Boroojeny, SB

Fard, MM

Celik, E

Turkoglu, EB

Altun, G

Alagoz, G

Oatts, JT

Wang, X

Loewen, NA

Zhang, L

Weizer, JS

Musch, DC

Besada, E

Shechtman, D

Frauens, BJ

Zeraatian, S

Zakeri, H

Hourang, MH

Ghaffarpasand, F

El Chehab, H

Le Corre, A

Giraud, JM

Ract-Madoux, G

Swalduz, B

Dot, C

Kasetti, SR

Desai, SP

Sivakumar, S

Sunderraj, P

Arieta, C

Amaral, M

Matuda, E

Crosta, C

de Carvalho Moreira Filho, D

José, N

Chen, TC

Unal, M

Yücel, I

Akar, Y

Scuderi, G

Regine, F

Perdicchi, A

Mannino, G

Recupero, SM

Kotecha, A

Elsheikh, A

Roberts, CR

Zhu, H

Garway-Heath, DF

Robin, AL

Feist, RM

Palmer, DJ

Fiscella, R

Ernest, JT

Tripathi, R

Torczynski, E

Farber, M

Hu, YZ

Wei, HR

Stewart, WC

Ritch, R

Shin, DH

Lehmann, RP

Shrader, CE

van Buskirk, EM

Toris, CB

Tafoya, ME

Camras, CB

Yablonski, ME

Bömer, TG

Lagrèze, WD

Funk, J

Hong, C

Song, KY

Cullom, RD

Schwartz, LW

Araie, M

Ishi, K

Nagasubramanian, S

Hitchings, RA

Demailly, P

Chuniaud, M

Pannarale, MR

Pecori-Giraldi, J

Stodtmeister, R

Parsons, DG

Polarz, H

Böhrer, H

Martin, E

Wolfrum, J

Völcker, HE

Birt, CM

Reed, SY

McCarty, B

Kim, C

Frenkel, RE

Núñez, M

Figueira, A

Guerra, V

Baños, G

Alvarez, ML

Rodríguez, M

Laibovitz, R

Horwitz, B

Stewart, RH

Kottler, M

Threlkeld, AB

Assalian, AA

Allingham, RR

Shields, MB

Rosenberg, LF

Krupin, T

Ruderman, J

McDaniel, DL

Siegfried, C

Karalekas, DP

Grewal, RK

Gieser, DK

Williams, R

Morrison, JC

Nylander, KB

Lauer, AK

Cepurna, WO

Johnson, E

Sterk, CC

Renzenbrink-Bubberman, AC

van Best, JA

Byrd, S

Singh, K

Lewis, R

Perkins, TW

Gangnon, R

Kaufman, PL

Heatley, GA

Chevrier, RL

Assalian, A

Duperré, J

Lesk, MR

Ren, J

Chung, HS

Glover, BK

Juzych, MS

Hughes, BA

Barnes, SD

Campagna, JA

Dirks, MS

Doe, EA

Chakraborty, P

Villada, JR

Tinu, A

Mittra, RA

Pollack, JS

Dev, S

Han, DP

Mieler, WF

Pulido, JS

Connor, TB

Lacheretz, F

Barbier, A

Serradeil-Le Gal, C

Elena, PP

Maffrand, JP

Le Fur, G

Rainer, G

Menapace, R

Findl, O

Georgopoulos, M

Kiss, B

Heinze, G

Sciscio, A

Casswell, AG

Ang, RT

Grosskreutz, CL

Pasquale, LR

Fan, JT

Zhao, J

Mao, J

Liu, X

Romanowski, A

Prata Júnior, JA

Rehder, JR

Mello, PA

Yüksel, N

Güler, C

Caglar, Y

Elibol, O

Raspiller, A

Berrod, JP

Yaldo, MK

Parrow, KA

Lee, SH

Lee, SY

Himber, J

de Burlet, G

Andermann, G

Kitazawa, Y

Taniguchi, T

Sugiyama, K

Jampel, HD

Abrams, DA

Crandall, AS

Caldwell, DR

Schnitzer, DB

Pollack, IP

Rader, JE

Reaves, TA

Dandona, L

Quigley, HA

House, B

Enger, C

Brown, RH

Lynch, MG

Mandell, AI

Wilensky, JT

Schwartz, AL

Gaasterland, DE

DeFaller, JM

Higginbotham, EJ

Clinical Trials (3)

Trial Overview

Trial	Phase	Enrollment	Study Type	Start Date	Status
Short-term Intraocular Pressure Control After YAG Iridotomy - Comparison Between Brimonidine 0.1% vs. 0.2%[NCT01417858]		50 participants (Anticipated)	Interventional	2010-11-30	Recruiting
Central Corneal Thickness and 24-hour Fluctuation of Intraocular Pressure[NCT00941525]	Phase 4	174 participants (Actual)	Interventional	2009-09-30	Completed
A Prospective, Randomized Study Comparing the Effects of Topical Aqueous Suppressants on Intraocular Gas Duration Following Pars Plana Vitrectomy[NCT01257698]		21 participants (Actual)	Interventional	2010-02-28	Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial

Phase

Enrollment

Study Type

Start Date

Status

Short-term Intraocular Pressure Control After YAG Iridotomy - Comparison Between Brimonidine 0.1% vs. 0.2%[NCT01417858]

50 participants (Anticipated)

Interventional

2010-11-30

Recruiting

Central Corneal Thickness and 24-hour Fluctuation of Intraocular Pressure[NCT00941525]

Phase 4

174 participants (Actual)

Interventional

2009-09-30

Completed

A Prospective, Randomized Study Comparing the Effects of Topical Aqueous Suppressants on Intraocular Gas Duration Following Pars Plana Vitrectomy[NCT01257698]

21 participants (Actual)

Interventional

2010-02-28

Completed

[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Duration of Intraocular Gas

Patients will self-monitor gas bubble duration and will receive weekly phone calls by the study coordinator until gas disappearance is confirmed. (NCT01257698)
Timeframe: Up to 4 weeks

Intervention	days (Mean)
Dorzolamide-timolol Topical Drops	17.1
Standard of Care	18.1

Intervention

days (Mean)

Dorzolamide-timolol Topical Drops

17.1

Standard of Care

18.1

Article	Year
Perioperative medications for preventing temporarily increased intraocular pressure after laser trabeculoplasty. The Cochrane database of systematic reviews, 2017, 02-23, Volume: 2 Topics: Adrenergic alpha-2 Receptor Agonists; Antihypertensive Agents; Brimonidine Tartrate; Clonidine; Conj	2017
Questions concerning the role of apraclonidine in the management of glaucoma. Archives of ophthalmology (Chicago, Ill. : 1960), 1995, Volume: 113, Issue:6 Topics: Adrenergic alpha-Agonists; Clonidine; Glaucoma, Open-Angle; Humans; Intraocular Pressure; Ocular Hyp	1995

Article

Year

Perioperative medications for preventing temporarily increased intraocular pressure after laser trabeculoplasty.

The Cochrane database of systematic reviews, 2017, 02-23, Volume: 2

Topics: Adrenergic alpha-2 Receptor Agonists; Antihypertensive Agents; Brimonidine Tartrate; Clonidine; Conj

2017

Questions concerning the role of apraclonidine in the management of glaucoma.

Archives of ophthalmology (Chicago, Ill. : 1960), 1995, Volume: 113, Issue:6

Topics: Adrenergic alpha-Agonists; Clonidine; Glaucoma, Open-Angle; Humans; Intraocular Pressure; Ocular Hyp

1995

Article	Year
Effect of Topically Applied 0.5% Apraclonidine Versus 0.5% Timolol Maleate on Intraocular Pressure of Healthy Horses. Journal of equine veterinary science, 2022, Volume: 111 Topics: Adrenergic alpha-Agonists; Animals; Clonidine; Double-Blind Method; Female; Horse Diseases; Horses;	2022
Effect of Apraclonidine and Diclofenac on Early Changes in Intraocular Pressure After Selective Laser Trabeculoplasty. Journal of glaucoma, 2020, Volume: 29, Issue:4 Topics: Adrenergic alpha-2 Receptor Agonists; Aged; Anti-Inflammatory Agents, Non-Steroidal; Clonidine; Dicl	2020
Effect of oral clonidine on acute intraocular pressure rise after cataract extraction under general anaesthesia. JPMA. The Journal of the Pakistan Medical Association, 2012, Volume: 62, Issue:12 Topics: Administration, Oral; Aged; Analysis of Variance; Anesthesia, General; Antihypertensive Agents; Cata	2012
Short-term effect of topical brinzolamide 1%-timolol 0.5% fixed combination on human central corneal thickness. Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics, 2015, Volume: 31, Issue:4 Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic beta-Antagonists; Aged; Capsule Opacification; Carb	2015
Effect of alpha-2-agonist premedication on intraocular pressure after selective laser trabeculoplasty. Indian journal of ophthalmology, 2015, Volume: 63, Issue:12 Topics: Adrenergic alpha-2 Receptor Agonists; Aged; Brimonidine Tartrate; Clonidine; Female; Glaucoma, Open-	2015
Effect of oral clonidine on acute intraocular pressure rise after phacoemulsification: a prospective double-blind, randomized, clinical trial. Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics, 2011, Volume: 27, Issue:3 Topics: Acute Disease; Administration, Oral; Adrenergic alpha-2 Receptor Agonists; Aged; Clonidine; Double-B	2011
[Efficacy of prophylactic treatment of intraocular pressure spikes due to intravitreal injections]. Journal francais d'ophtalmologie, 2012, Volume: 35, Issue:8 Topics: Acetazolamide; Aged; Antibodies, Monoclonal, Humanized; Antihypertensive Agents; Bevacizumab; Brimon	2012
Preventing intraocular pressure increase after phacoemulsification and the role of perioperative apraclonidine. Journal of cataract and refractive surgery, 2002, Volume: 28, Issue:12 Topics: Administration, Topical; Adrenergic alpha-Agonists; Aged; Aged, 80 and over; Clonidine; Double-Blind	2002
Dorzolamide X apraclonidine in the prevention of the intraocular pressure spike after Nd : YAG laser posterior capsulotomy. Current eye research, 2002, Volume: 25, Issue:4 Topics: Adrenergic alpha-Agonists; Adult; Aged; Aged, 80 and over; Carbonic Anhydrase Inhibitors; Clonidine;	2002
Brimonidine 0.15% versus apraclonidine 0.5% for prevention of intraocular pressure elevation after anterior segment laser surgery. Journal of cataract and refractive surgery, 2005, Volume: 31, Issue:9 Topics: Adrenergic alpha-Agonists; Aged; Anterior Eye Segment; Antihypertensive Agents; Blood Pressure; Brim	2005
Brinzolamide 1% versus apraclonidine 0.5% to prevent intraocular pressure elevation after neodymium:YAG laser posterior capsulotomy. Journal of cataract and refractive surgery, 2006, Volume: 32, Issue:9 Topics: Adrenergic alpha-Agonists; Adult; Aged; Aged, 80 and over; Carbonic Anhydrase Inhibitors; Clonidine;	2006
Comparative efficacy of acetazolamide and apraclonidine in the control of intraocular pressure following phacoemulsification. Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift fur Augenheilkunde, 2006, Volume: 220, Issue:6 Topics: Acetazolamide; Administration, Oral; Administration, Topical; Adrenergic alpha-Agonists; Aged; Aged,	2006
Effectiveness of apraclonidine and acetazolamide in preventing postoperative intraocular pressure spikes after extracapsular cataract extraction. Journal of cataract and refractive surgery, 1995, Volume: 21, Issue:2 Topics: Acetazolamide; Administration, Oral; Administration, Topical; Adrenergic alpha-Agonists; Aged; Catar	1995
[Topical clonidine in prevention of intra-ocular hypertension after Nd: YAG laser therapy]. [Zhonghua yan ke za zhi] Chinese journal of ophthalmology, 1994, Volume: 30, Issue:3 Topics: Adolescent; Adult; Aged; Aged, 80 and over; Child; Child, Preschool; Clonidine; Female; Glaucoma, An	1994
The efficacy of apraclonidine as an adjunct to timolol therapy. Apraclonidine Adjunctive Therapy Study Group. Archives of ophthalmology (Chicago, Ill. : 1960), 1995, Volume: 113, Issue:3 Topics: Adrenergic alpha-Agonists; Chemotherapy, Adjuvant; Clonidine; Double-Blind Method; Drug Administrati	1995
Effects of apraclonidine on aqueous humor dynamics in human eyes. Ophthalmology, 1995, Volume: 102, Issue:3 Topics: Adrenergic alpha-Agonists; Adult; Aged; Anterior Eye Segment; Aqueous Humor; Clonidine; Double-Blind	1995
[Increased intraocular pressure after cataract extraction--effect of surgical technique, surgical procedure and preventive drug administration. A prospective, randomized double-blind study]. Klinische Monatsblatter fur Augenheilkunde, 1995, Volume: 206, Issue:1 Topics: Acetazolamide; Adrenergic alpha-Agonists; Aged; Aged, 80 and over; Cataract Extraction; Clinical Com	1995
Effect of topical apraclonidine on the frequency of intraocular pressure elevations after combined extracapsular cataract extraction and trabeculectomy. Ophthalmology, 1993, Volume: 100, Issue:5 Topics: Adrenergic alpha-Agonists; Aged; Cataract Extraction; Clonidine; Double-Blind Method; Female; Glauco	1993
Effects of apraclonidine on intraocular pressure and blood-aqueous barrier permeability after phacoemulsification and intraocular lens implantation. American journal of ophthalmology, 1993, Jul-15, Volume: 116, Issue:1 Topics: Adrenergic alpha-Agonists; Aged; Aqueous Humor; Blood; Cataract Extraction; Cell Membrane Permeabili	1993
Comparison of apraclonidine and timolol in chronic open-angle glaucoma. A three-month study. Ophthalmology, 1993, Volume: 100, Issue:9 Topics: Adult; Aged; Aged, 80 and over; Chronic Disease; Clonidine; Double-Blind Method; Drug Administration	1993
Oral clonidine premedication prevents the rise in intraocular pressure following succinylcholine administration. German journal of ophthalmology, 1993, Volume: 2, Issue:2 Topics: Administration, Oral; Aged; Blood Pressure; Clonidine; Clorazepate Dipotassium; Double-Blind Method;	1993
One vs. two doses of 1.0% apraclonidine for prophylaxis of intraocular pressure spike after argon laser trabeculoplasty. Canadian journal of ophthalmology. Journal canadien d'ophtalmologie, 1995, Volume: 30, Issue:5 Topics: Aged; Antihypertensive Agents; Clonidine; Female; Humans; Laser Therapy; Male; Ocular Hypertension;	1995
[Comparative study of clonidine and lidocaine on the attenuation of the intraocular pressure increase associated with laryngoscopy and endotracheal intubation]. Revista espanola de anestesiologia y reanimacion, 1995, Volume: 42, Issue:8 Topics: Adult; Aged; Blood Pressure; Clonidine; Double-Blind Method; Female; Heart Rate; Humans; Intraocular	1995
A 90-day study of the efficacy and side effects of 0.25% and 0.5% apraclonidine vs 0.5% timolol. Apraclonidine Primary Therapy Study Group. Archives of ophthalmology (Chicago, Ill. : 1960), 1996, Volume: 114, Issue:8 Topics: Administration, Topical; Adrenergic alpha-Agonists; Adrenergic beta-Antagonists; Clonidine; Double-B	1996
Apraclonidine 0.5% versus 1% for controlling intraocular pressure elevation after argon laser trabeculoplasty. Ophthalmic surgery and lasers, 1996, Volume: 27, Issue:8 Topics: Administration, Topical; Adrenergic alpha-Agonists; Clonidine; Follow-Up Studies; Glaucoma; Humans;	1996
Apraclonidine and anterior segment laser surgery. Comparison of 0.5% versus 1.0% apraclonidine for prevention of postoperative intraocular pressure rise. Ophthalmology, 1995, Volume: 102, Issue:9 Topics: Adrenergic alpha-Agonists; Aged; Anterior Eye Segment; Clonidine; Double-Blind Method; Glaucoma; Hum	1995
The effect of 1% apraclonidine on intraocular pressure after cataract surgery. Ophthalmic surgery and lasers, 1998, Volume: 29, Issue:6 Topics: Administration, Topical; Adolescent; Adrenergic alpha-Agonists; Cataract Extraction; Clonidine; Doub	1998
Medical control of intraocular pressure after cataract surgery. Journal of cataract and refractive surgery, 1998, Volume: 24, Issue:11 Topics: Acetazolamide; Administration, Oral; Administration, Topical; Adrenergic alpha-Agonists; Aged; Carbo	1998
Apraclonidine 0.5% versus brimonidine 0.2% for the control of intraocular pressure elevation following anterior segment laser procedures. Ophthalmic surgery and lasers, 1999, Volume: 30, Issue:3 Topics: Adrenergic alpha-Agonists; Adult; Aged; Aged, 80 and over; Anterior Eye Segment; Brimonidine Tartrat	1999
Efficacy of apraclonidine 1% versus pilocarpine 4% for prophylaxis of intraocular pressure spike after argon laser trabeculoplasty. Ophthalmology, 1999, Volume: 106, Issue:6 Topics: Aged; Clonidine; Female; Glaucoma, Open-Angle; Humans; Incidence; Intraocular Pressure; Laser Therap	1999
Control of intraocular pressure elevations after argon laser trabeculoplasty: comparison of brimonidine 0.2% to apraclonidine 1.0%. Ophthalmology, 1999, Volume: 106, Issue:10 Topics: Adrenergic alpha-Agonists; Aged; Brimonidine Tartrate; Clonidine; Double-Blind Method; Female; Glauc	1999
The use of topical aqueous suppressants in the prevention of postoperative intraocular pressure elevation after pars plana vitrectomy with long-acting gas tamponade. Ophthalmology, 2000, Volume: 107, Issue:3 Topics: Administration, Topical; Antihypertensive Agents; Aqueous Humor; Brimonidine Tartrate; Clonidine; Fl	2000
Randomised fellow eye comparison of the effectiveness of dorzolamide and apraclonidine on intraocular pressure following phacoemulsification cataract surgery. Eye (London, England), 2000, Volume: 14 Pt 5 Topics: Adrenergic alpha-Agonists; Aged; Aged, 80 and over; Antihypertensive Agents; Carbonic Anhydrase Inhi	2000
Effectiveness of apraclonidine 1% in preventing intraocular pressure rise following macular hole surgery. The British journal of ophthalmology, 2001, Volume: 85, Issue:2 Topics: Adrenergic alpha-Agonists; Aged; Aged, 80 and over; Blood Pressure; Clonidine; Double-Blind Method;	2001
Brimonidine 0.2% versus apraclonidine 0.5% for prevention of intraocular pressure elevations after anterior segment laser surgery. Ophthalmology, 2001, Volume: 108, Issue:6 Topics: Adrenergic alpha-Agonists; Aged; Anterior Eye Segment; Blood Pressure; Brimonidine Tartrate; Clonidi	2001
[Apraclonidine prevents the acute increase of intraocular pressure in brown eyes with Nd:YAG laser iridectomy]. [Zhonghua yan ke za zhi] Chinese journal of ophthalmology, 1998, Volume: 34, Issue:3 Topics: Clonidine; Female; Humans; Intraocular Pressure; Iridectomy; Laser Therapy; Male; Ocular Hypertensio	1998
Apraclonidine and early postoperative intraocular hypertension after cataract extraction. Acta ophthalmologica, 1992, Volume: 70, Issue:4 Topics: Adrenergic alpha-Agonists; Cataract Extraction; Clonidine; Female; Humans; Intraocular Pressure; Len	1992
Apraclonidine and clonidine: a comparison of efficacy and side effects in normal and ocular hypertensive volunteers. International ophthalmology, 1992, Volume: 16, Issue:4-5 Topics: Adrenergic beta-Agonists; Adult; Aged; Clonidine; Double-Blind Method; Female; Humans; Intraocular P	1992
[Efficacy and tolerability of apraclonidine (ALO 2145, 1%) in the prevention of early ocular hypertonia, after trabeculoretraction using argon laser and posterior capsulotomy using Nd:YAG laser]. Journal francais d'ophtalmologie, 1992, Volume: 15, Issue:12 Topics: Adrenergic alpha-Agonists; Adult; Clonidine; Double-Blind Method; Humans; Laser Therapy; Lens Capsul	1992
Additive effect of 1% apraclonidine hydrochloride to nonselective beta-blockers. Ophthalmology, 1991, Volume: 98, Issue:7 Topics: Adrenergic alpha-Agonists; Clonidine; Double-Blind Method; Drug Synergism; Female; Glaucoma, Open-An	1991
A limited comparison of apraclonidine's dose response in subjects with normal or increased intraocular pressure. American journal of ophthalmology, 1989, Sep-15, Volume: 108, Issue:3 Topics: Adult; Aged; Circadian Rhythm; Clinical Trials as Topic; Clonidine; Dose-Response Relationship, Drug	1989
"Outlier" intraocular pressure readings: valid or invalid for statistical analysis? Ophthalmic surgery, 1989, Volume: 20, Issue:10 Topics: Analysis of Variance; Clinical Trials as Topic; Clonidine; Data Interpretation, Statistical; Double-	1989
Effects of ALO 2145 on intraocular pressure following argon laser trabeculoplasty. Archives of ophthalmology (Chicago, Ill. : 1960), 1987, Volume: 105, Issue:5 Topics: Adrenergic alpha-Agonists; Adult; Aged; Clinical Trials as Topic; Clonidine; Double-Blind Method; Fe	1987
ALO 2145 reduces the intraocular pressure elevation after anterior segment laser surgery. Ophthalmology, 1988, Volume: 95, Issue:3 Topics: Aged; Anterior Eye Segment; Clinical Trials as Topic; Clonidine; Double-Blind Method; Female; Humans	1988

Article

Year

Effect of Topically Applied 0.5% Apraclonidine Versus 0.5% Timolol Maleate on Intraocular Pressure of Healthy Horses.

Journal of equine veterinary science, 2022, Volume: 111

Topics: Adrenergic alpha-Agonists; Animals; Clonidine; Double-Blind Method; Female; Horse Diseases; Horses;

2022

Effect of Apraclonidine and Diclofenac on Early Changes in Intraocular Pressure After Selective Laser Trabeculoplasty.

Journal of glaucoma, 2020, Volume: 29, Issue:4

Topics: Adrenergic alpha-2 Receptor Agonists; Aged; Anti-Inflammatory Agents, Non-Steroidal; Clonidine; Dicl

2020

Effect of oral clonidine on acute intraocular pressure rise after cataract extraction under general anaesthesia.

JPMA. The Journal of the Pakistan Medical Association, 2012, Volume: 62, Issue:12

Topics: Administration, Oral; Aged; Analysis of Variance; Anesthesia, General; Antihypertensive Agents; Cata

2012

Short-term effect of topical brinzolamide 1%-timolol 0.5% fixed combination on human central corneal thickness.

Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics, 2015, Volume: 31, Issue:4

Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic beta-Antagonists; Aged; Capsule Opacification; Carb

2015

Effect of alpha-2-agonist premedication on intraocular pressure after selective laser trabeculoplasty.

Indian journal of ophthalmology, 2015, Volume: 63, Issue:12

Topics: Adrenergic alpha-2 Receptor Agonists; Aged; Brimonidine Tartrate; Clonidine; Female; Glaucoma, Open-

2015

Effect of oral clonidine on acute intraocular pressure rise after phacoemulsification: a prospective double-blind, randomized, clinical trial.

Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics, 2011, Volume: 27, Issue:3

Topics: Acute Disease; Administration, Oral; Adrenergic alpha-2 Receptor Agonists; Aged; Clonidine; Double-B

2011

[Efficacy of prophylactic treatment of intraocular pressure spikes due to intravitreal injections].

Journal francais d'ophtalmologie, 2012, Volume: 35, Issue:8

Topics: Acetazolamide; Aged; Antibodies, Monoclonal, Humanized; Antihypertensive Agents; Bevacizumab; Brimon

2012

Preventing intraocular pressure increase after phacoemulsification and the role of perioperative apraclonidine.

Journal of cataract and refractive surgery, 2002, Volume: 28, Issue:12

Topics: Administration, Topical; Adrenergic alpha-Agonists; Aged; Aged, 80 and over; Clonidine; Double-Blind

2002

Dorzolamide X apraclonidine in the prevention of the intraocular pressure spike after Nd : YAG laser posterior capsulotomy.

Current eye research, 2002, Volume: 25, Issue:4

Topics: Adrenergic alpha-Agonists; Adult; Aged; Aged, 80 and over; Carbonic Anhydrase Inhibitors; Clonidine;

2002

Brimonidine 0.15% versus apraclonidine 0.5% for prevention of intraocular pressure elevation after anterior segment laser surgery.

Journal of cataract and refractive surgery, 2005, Volume: 31, Issue:9

Topics: Adrenergic alpha-Agonists; Aged; Anterior Eye Segment; Antihypertensive Agents; Blood Pressure; Brim

2005

Brinzolamide 1% versus apraclonidine 0.5% to prevent intraocular pressure elevation after neodymium:YAG laser posterior capsulotomy.

Journal of cataract and refractive surgery, 2006, Volume: 32, Issue:9

Topics: Adrenergic alpha-Agonists; Adult; Aged; Aged, 80 and over; Carbonic Anhydrase Inhibitors; Clonidine;

2006

Comparative efficacy of acetazolamide and apraclonidine in the control of intraocular pressure following phacoemulsification.

Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift fur Augenheilkunde, 2006, Volume: 220, Issue:6

Topics: Acetazolamide; Administration, Oral; Administration, Topical; Adrenergic alpha-Agonists; Aged; Aged,

2006

Effectiveness of apraclonidine and acetazolamide in preventing postoperative intraocular pressure spikes after extracapsular cataract extraction.

Journal of cataract and refractive surgery, 1995, Volume: 21, Issue:2

Topics: Acetazolamide; Administration, Oral; Administration, Topical; Adrenergic alpha-Agonists; Aged; Catar

1995

[Topical clonidine in prevention of intra-ocular hypertension after Nd: YAG laser therapy].

[Zhonghua yan ke za zhi] Chinese journal of ophthalmology, 1994, Volume: 30, Issue:3

Topics: Adolescent; Adult; Aged; Aged, 80 and over; Child; Child, Preschool; Clonidine; Female; Glaucoma, An

1994

The efficacy of apraclonidine as an adjunct to timolol therapy. Apraclonidine Adjunctive Therapy Study Group.

Archives of ophthalmology (Chicago, Ill. : 1960), 1995, Volume: 113, Issue:3

Topics: Adrenergic alpha-Agonists; Chemotherapy, Adjuvant; Clonidine; Double-Blind Method; Drug Administrati

1995

Effects of apraclonidine on aqueous humor dynamics in human eyes.

Ophthalmology, 1995, Volume: 102, Issue:3

Topics: Adrenergic alpha-Agonists; Adult; Aged; Anterior Eye Segment; Aqueous Humor; Clonidine; Double-Blind

1995

[Increased intraocular pressure after cataract extraction--effect of surgical technique, surgical procedure and preventive drug administration. A prospective, randomized double-blind study].

Klinische Monatsblatter fur Augenheilkunde, 1995, Volume: 206, Issue:1

Topics: Acetazolamide; Adrenergic alpha-Agonists; Aged; Aged, 80 and over; Cataract Extraction; Clinical Com

1995

Effect of topical apraclonidine on the frequency of intraocular pressure elevations after combined extracapsular cataract extraction and trabeculectomy.

Ophthalmology, 1993, Volume: 100, Issue:5

Topics: Adrenergic alpha-Agonists; Aged; Cataract Extraction; Clonidine; Double-Blind Method; Female; Glauco

1993

Effects of apraclonidine on intraocular pressure and blood-aqueous barrier permeability after phacoemulsification and intraocular lens implantation.

American journal of ophthalmology, 1993, Jul-15, Volume: 116, Issue:1

Topics: Adrenergic alpha-Agonists; Aged; Aqueous Humor; Blood; Cataract Extraction; Cell Membrane Permeabili

1993

Comparison of apraclonidine and timolol in chronic open-angle glaucoma. A three-month study.

Ophthalmology, 1993, Volume: 100, Issue:9

Topics: Adult; Aged; Aged, 80 and over; Chronic Disease; Clonidine; Double-Blind Method; Drug Administration

1993

Oral clonidine premedication prevents the rise in intraocular pressure following succinylcholine administration.

German journal of ophthalmology, 1993, Volume: 2, Issue:2

Topics: Administration, Oral; Aged; Blood Pressure; Clonidine; Clorazepate Dipotassium; Double-Blind Method;

1993

One vs. two doses of 1.0% apraclonidine for prophylaxis of intraocular pressure spike after argon laser trabeculoplasty.

Canadian journal of ophthalmology. Journal canadien d'ophtalmologie, 1995, Volume: 30, Issue:5

Topics: Aged; Antihypertensive Agents; Clonidine; Female; Humans; Laser Therapy; Male; Ocular Hypertension;

1995

[Comparative study of clonidine and lidocaine on the attenuation of the intraocular pressure increase associated with laryngoscopy and endotracheal intubation].

Revista espanola de anestesiologia y reanimacion, 1995, Volume: 42, Issue:8

Topics: Adult; Aged; Blood Pressure; Clonidine; Double-Blind Method; Female; Heart Rate; Humans; Intraocular

1995

A 90-day study of the efficacy and side effects of 0.25% and 0.5% apraclonidine vs 0.5% timolol. Apraclonidine Primary Therapy Study Group.

Archives of ophthalmology (Chicago, Ill. : 1960), 1996, Volume: 114, Issue:8

Topics: Administration, Topical; Adrenergic alpha-Agonists; Adrenergic beta-Antagonists; Clonidine; Double-B

1996

Apraclonidine 0.5% versus 1% for controlling intraocular pressure elevation after argon laser trabeculoplasty.

Ophthalmic surgery and lasers, 1996, Volume: 27, Issue:8

Topics: Administration, Topical; Adrenergic alpha-Agonists; Clonidine; Follow-Up Studies; Glaucoma; Humans;

1996

Apraclonidine and anterior segment laser surgery. Comparison of 0.5% versus 1.0% apraclonidine for prevention of postoperative intraocular pressure rise.

Ophthalmology, 1995, Volume: 102, Issue:9

Topics: Adrenergic alpha-Agonists; Aged; Anterior Eye Segment; Clonidine; Double-Blind Method; Glaucoma; Hum

1995

The effect of 1% apraclonidine on intraocular pressure after cataract surgery.

Ophthalmic surgery and lasers, 1998, Volume: 29, Issue:6

Topics: Administration, Topical; Adolescent; Adrenergic alpha-Agonists; Cataract Extraction; Clonidine; Doub

1998

Medical control of intraocular pressure after cataract surgery.

Journal of cataract and refractive surgery, 1998, Volume: 24, Issue:11

Topics: Acetazolamide; Administration, Oral; Administration, Topical; Adrenergic alpha-Agonists; Aged; Carbo

1998

Apraclonidine 0.5% versus brimonidine 0.2% for the control of intraocular pressure elevation following anterior segment laser procedures.

Ophthalmic surgery and lasers, 1999, Volume: 30, Issue:3

Topics: Adrenergic alpha-Agonists; Adult; Aged; Aged, 80 and over; Anterior Eye Segment; Brimonidine Tartrat

1999

Efficacy of apraclonidine 1% versus pilocarpine 4% for prophylaxis of intraocular pressure spike after argon laser trabeculoplasty.

Ophthalmology, 1999, Volume: 106, Issue:6

Topics: Aged; Clonidine; Female; Glaucoma, Open-Angle; Humans; Incidence; Intraocular Pressure; Laser Therap

1999

Control of intraocular pressure elevations after argon laser trabeculoplasty: comparison of brimonidine 0.2% to apraclonidine 1.0%.

Ophthalmology, 1999, Volume: 106, Issue:10

Topics: Adrenergic alpha-Agonists; Aged; Brimonidine Tartrate; Clonidine; Double-Blind Method; Female; Glauc

1999

The use of topical aqueous suppressants in the prevention of postoperative intraocular pressure elevation after pars plana vitrectomy with long-acting gas tamponade.

Ophthalmology, 2000, Volume: 107, Issue:3

Topics: Administration, Topical; Antihypertensive Agents; Aqueous Humor; Brimonidine Tartrate; Clonidine; Fl

2000

Randomised fellow eye comparison of the effectiveness of dorzolamide and apraclonidine on intraocular pressure following phacoemulsification cataract surgery.

Eye (London, England), 2000, Volume: 14 Pt 5

Topics: Adrenergic alpha-Agonists; Aged; Aged, 80 and over; Antihypertensive Agents; Carbonic Anhydrase Inhi

2000

Effectiveness of apraclonidine 1% in preventing intraocular pressure rise following macular hole surgery.

The British journal of ophthalmology, 2001, Volume: 85, Issue:2

Topics: Adrenergic alpha-Agonists; Aged; Aged, 80 and over; Blood Pressure; Clonidine; Double-Blind Method;

2001

Brimonidine 0.2% versus apraclonidine 0.5% for prevention of intraocular pressure elevations after anterior segment laser surgery.

Ophthalmology, 2001, Volume: 108, Issue:6

Topics: Adrenergic alpha-Agonists; Aged; Anterior Eye Segment; Blood Pressure; Brimonidine Tartrate; Clonidi

2001

[Apraclonidine prevents the acute increase of intraocular pressure in brown eyes with Nd:YAG laser iridectomy].

[Zhonghua yan ke za zhi] Chinese journal of ophthalmology, 1998, Volume: 34, Issue:3

Topics: Clonidine; Female; Humans; Intraocular Pressure; Iridectomy; Laser Therapy; Male; Ocular Hypertensio

1998

Apraclonidine and early postoperative intraocular hypertension after cataract extraction.

Acta ophthalmologica, 1992, Volume: 70, Issue:4

Topics: Adrenergic alpha-Agonists; Cataract Extraction; Clonidine; Female; Humans; Intraocular Pressure; Len

1992

Apraclonidine and clonidine: a comparison of efficacy and side effects in normal and ocular hypertensive volunteers.

International ophthalmology, 1992, Volume: 16, Issue:4-5

Topics: Adrenergic beta-Agonists; Adult; Aged; Clonidine; Double-Blind Method; Female; Humans; Intraocular P

1992

[Efficacy and tolerability of apraclonidine (ALO 2145, 1%) in the prevention of early ocular hypertonia, after trabeculoretraction using argon laser and posterior capsulotomy using Nd:YAG laser].

Journal francais d'ophtalmologie, 1992, Volume: 15, Issue:12

Topics: Adrenergic alpha-Agonists; Adult; Clonidine; Double-Blind Method; Humans; Laser Therapy; Lens Capsul

1992

Additive effect of 1% apraclonidine hydrochloride to nonselective beta-blockers.

Ophthalmology, 1991, Volume: 98, Issue:7

Topics: Adrenergic alpha-Agonists; Clonidine; Double-Blind Method; Drug Synergism; Female; Glaucoma, Open-An

1991

A limited comparison of apraclonidine's dose response in subjects with normal or increased intraocular pressure.

American journal of ophthalmology, 1989, Sep-15, Volume: 108, Issue:3

Topics: Adult; Aged; Circadian Rhythm; Clinical Trials as Topic; Clonidine; Dose-Response Relationship, Drug

1989

"Outlier" intraocular pressure readings: valid or invalid for statistical analysis?

Ophthalmic surgery, 1989, Volume: 20, Issue:10

Topics: Analysis of Variance; Clinical Trials as Topic; Clonidine; Data Interpretation, Statistical; Double-

1989

Effects of ALO 2145 on intraocular pressure following argon laser trabeculoplasty.

Archives of ophthalmology (Chicago, Ill. : 1960), 1987, Volume: 105, Issue:5

Topics: Adrenergic alpha-Agonists; Adult; Aged; Clinical Trials as Topic; Clonidine; Double-Blind Method; Fe

1987

ALO 2145 reduces the intraocular pressure elevation after anterior segment laser surgery.

Ophthalmology, 1988, Volume: 95, Issue:3

Topics: Aged; Anterior Eye Segment; Clinical Trials as Topic; Clonidine; Double-Blind Method; Female; Humans

1988

Article	Year
INN Common stem: -onidine. Prescrire international, 2017, Volume: 26, Issue:181 Topics: Adrenergic alpha-2 Receptor Agonists; Antimalarials; Brimonidine Tartrate; Cinchona Alkaloids; Cloni	2017
Recurrent serous macular detachment after topical ocular hypotensive medication. Clinical & experimental optometry, 2008, Volume: 91, Issue:6 Topics: Administration, Topical; Antihypertensive Agents; Clonidine; Drug Combinations; Drug Therapy, Combin	2008
Corneal thickness- and age-related biomechanical properties of the cornea measured with the ocular response analyzer. Investigative ophthalmology & visual science, 2006, Volume: 47, Issue:12 Topics: Adrenergic alpha-Agonists; Adult; Aged; Aged, 80 and over; Aging; Biomechanical Phenomena; Clonidine	2006
Effect of apraclonidine hydrochloride on the attack of Posner-Schlossman syndrome. Korean journal of ophthalmology : KJO, 1993, Volume: 7, Issue:1 Topics: Adolescent; Adrenergic alpha-Agonists; Adult; Aged; Clonidine; Female; Glaucoma, Open-Angle; Hemodyn	1993
The effect of apraclonidine on the intraocular pressure of glaucoma patients following Nd:YAG laser posterior capsulotomy. Ophthalmic surgery, 1993, Volume: 24, Issue:9 Topics: Adrenergic alpha-Agonists; Aged; Clonidine; Female; Glaucoma; Humans; Incidence; Intraocular Pressur	1993
Glaucoma drops control intraocular pressure and protect optic nerves in a rat model of glaucoma. Investigative ophthalmology & visual science, 1998, Volume: 39, Issue:3 Topics: Adrenergic alpha-Agonists; Adrenergic beta-Antagonists; Animals; Betaxolol; Clonidine; Disease Model	1998
The rarity of clinically significant rise in intraocular pressure after laser peripheral iridotomy with apraclonidine. Ophthalmology, 1998, Volume: 105, Issue:12 Topics: Adrenergic alpha-Agonists; Adult; Aged; Aged, 80 and over; Chemotherapy, Adjuvant; Clonidine; Female	1998
Medical control of IOP after cataract surgery. Journal of cataract and refractive surgery, 2000, Volume: 26, Issue:2 Topics: Acetazolamide; Adrenergic alpha-Agonists; Carbonic Anhydrase Inhibitors; Clonidine; Drug Therapy, Co	2000
Effect of SR121463, a selective non-peptide vasopressin V2 receptor antagonist, in a rabbit model of ocular hypertension. Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics, 2000, Volume: 16, Issue:3 Topics: Administration, Oral; Administration, Topical; Animals; Antidiuretic Hormone Receptor Antagonists; C	2000
Prophylactic use of apraclonidine for intraocular pressure increase after Nd:YAG Capsulotomies. American journal of ophthalmology, 1992, Sep-15, Volume: 114, Issue:3 Topics: Adrenergic alpha-Agonists; Cataract Extraction; Clonidine; Humans; Intraocular Pressure; Laser Thera	1992
Effects of adrenergic agents on alpha-chymotrypsin-induced ocular hypertension in albino and pigmented rabbits: a comparative study. Journal of ocular pharmacology, 1989,Summer, Volume: 5, Issue:2 Topics: Adrenergic beta-Antagonists; Animals; Betaxolol; Chymotrypsin; Clonidine; Ocular Hypertension; Pigme	1989
Use of apraclonidine to reduce acute intraocular pressure rise following Q-switched Nd:YAG laser iridotomy. Ophthalmic surgery, 1989, Volume: 20, Issue:1 Topics: Aged; Clonidine; Female; Glaucoma; Gonioscopy; Humans; Intraocular Pressure; Iris; Laser Therapy; Ma	1989
Hypotony following instillation of apraclonidine for increased intraocular pressure after trabeculoplasty. American journal of ophthalmology, 1989, Aug-15, Volume: 108, Issue:2 Topics: Aged; Clonidine; Humans; Intraocular Pressure; Male; Ocular Hypertension; Recurrence; Trabeculectomy	1989

Article

Year

INN Common stem: -onidine.

Prescrire international, 2017, Volume: 26, Issue:181

Topics: Adrenergic alpha-2 Receptor Agonists; Antimalarials; Brimonidine Tartrate; Cinchona Alkaloids; Cloni

2017

Recurrent serous macular detachment after topical ocular hypotensive medication.

Clinical & experimental optometry, 2008, Volume: 91, Issue:6

Topics: Administration, Topical; Antihypertensive Agents; Clonidine; Drug Combinations; Drug Therapy, Combin

2008

Corneal thickness- and age-related biomechanical properties of the cornea measured with the ocular response analyzer.

Investigative ophthalmology & visual science, 2006, Volume: 47, Issue:12

Topics: Adrenergic alpha-Agonists; Adult; Aged; Aged, 80 and over; Aging; Biomechanical Phenomena; Clonidine

2006

Effect of apraclonidine hydrochloride on the attack of Posner-Schlossman syndrome.

Korean journal of ophthalmology : KJO, 1993, Volume: 7, Issue:1

Topics: Adolescent; Adrenergic alpha-Agonists; Adult; Aged; Clonidine; Female; Glaucoma, Open-Angle; Hemodyn

1993

The effect of apraclonidine on the intraocular pressure of glaucoma patients following Nd:YAG laser posterior capsulotomy.

Ophthalmic surgery, 1993, Volume: 24, Issue:9

Topics: Adrenergic alpha-Agonists; Aged; Clonidine; Female; Glaucoma; Humans; Incidence; Intraocular Pressur

1993

Glaucoma drops control intraocular pressure and protect optic nerves in a rat model of glaucoma.

Investigative ophthalmology & visual science, 1998, Volume: 39, Issue:3

Topics: Adrenergic alpha-Agonists; Adrenergic beta-Antagonists; Animals; Betaxolol; Clonidine; Disease Model

1998

The rarity of clinically significant rise in intraocular pressure after laser peripheral iridotomy with apraclonidine.

Ophthalmology, 1998, Volume: 105, Issue:12

Topics: Adrenergic alpha-Agonists; Adult; Aged; Aged, 80 and over; Chemotherapy, Adjuvant; Clonidine; Female

1998

Medical control of IOP after cataract surgery.

Journal of cataract and refractive surgery, 2000, Volume: 26, Issue:2

Topics: Acetazolamide; Adrenergic alpha-Agonists; Carbonic Anhydrase Inhibitors; Clonidine; Drug Therapy, Co

2000

Effect of SR121463, a selective non-peptide vasopressin V2 receptor antagonist, in a rabbit model of ocular hypertension.

Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics, 2000, Volume: 16, Issue:3

Topics: Administration, Oral; Administration, Topical; Animals; Antidiuretic Hormone Receptor Antagonists; C

2000

Prophylactic use of apraclonidine for intraocular pressure increase after Nd:YAG Capsulotomies.

American journal of ophthalmology, 1992, Sep-15, Volume: 114, Issue:3

Topics: Adrenergic alpha-Agonists; Cataract Extraction; Clonidine; Humans; Intraocular Pressure; Laser Thera

1992

Effects of adrenergic agents on alpha-chymotrypsin-induced ocular hypertension in albino and pigmented rabbits: a comparative study.

Journal of ocular pharmacology, 1989,Summer, Volume: 5, Issue:2

Topics: Adrenergic beta-Antagonists; Animals; Betaxolol; Chymotrypsin; Clonidine; Ocular Hypertension; Pigme

1989

Use of apraclonidine to reduce acute intraocular pressure rise following Q-switched Nd:YAG laser iridotomy.

Ophthalmic surgery, 1989, Volume: 20, Issue:1

Topics: Aged; Clonidine; Female; Glaucoma; Gonioscopy; Humans; Intraocular Pressure; Iris; Laser Therapy; Ma

1989

Hypotony following instillation of apraclonidine for increased intraocular pressure after trabeculoplasty.

American journal of ophthalmology, 1989, Aug-15, Volume: 108, Issue:2

Topics: Aged; Clonidine; Humans; Intraocular Pressure; Male; Ocular Hypertension; Recurrence; Trabeculectomy

1989

clonidine and Glaucoma, Suspect

Research Excerpts

Research

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