Page last updated: 2024-10-25

clonidine and Genital Neoplasms, Female

clonidine has been researched along with Genital Neoplasms, Female in 2 studies

Clonidine: An imidazoline sympatholytic agent that stimulates ALPHA-2 ADRENERGIC RECEPTORS and central IMIDAZOLINE RECEPTORS. It is commonly used in the management of HYPERTENSION.
clonidine (amino form) : A clonidine that is 4,5-dihydro-1H-imidazol-2-amine in which one of the amino hydrogens is replaced by a 2,6-dichlorophenyl group.

Genital Neoplasms, Female: Tumor or cancer of the female reproductive tract (GENITALIA, FEMALE).

Research

Studies (2)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's2 (100.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Kjølhede, P1
Bergdahl, O1
Borendal Wodlin, N1
Nilsson, L1
Del Pup, L1
Maggino, T1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Will Intrathecal Analgesia Contribute to a Faster Recovery Compared With Epidural Analgesia After Open Surgery for Gynecological Cancer. An Open Controlled Randomized Study.[NCT02026687]Phase 480 participants (Actual)Interventional2014-03-31Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Length of Stay

From day of surgery (Day 0) until discharge after surgery (NCT02026687)
Timeframe: Participants will be followed for the duration of hospital stay, an expected average of 4 days

Interventiondays (Median)
Epidural4.3
Spinal3.3

Change in Pain

"Pain at rest will be assessed using a numeric rating scale from 0 (no pain) to 10 (worst imaginable pain). Pain is documented on the day of surgery (day 0), 3 times daily postoperative day 1, 2, 3, 4, 5, 6, 7, 14, 21, 28, 35 and 42.~Scale: NRS Minimum value:0 Maximum value: 10. Higher scores indicate worse outcome." (NCT02026687)
Timeframe: Day of surgery (day 0) until 6 weeks after surgery

,
Interventionunits on a scale (Mean)
Pain at rest Day 0Pain at rest Day 1Pain at rest Day 2Pain at rest Day 3Pain at rest Day 4Pain at rest Day 5Pain at rest Day 6Pain at rest Day 7Pain at rest Day 14Pain at rest Day 21Pain at rest Day 28Pain at rest Day 35Pain at rest Day 42
Epidural1.51.61.52.91.41.11.01.10.80.50.20.30.5
Spinal2.73.22.11.41.61.21.11.00.70.30.20.30.1

Change in Quality of Life

"The questionnaire Short Form with 36 questions SF-36 will be used preoperatively and at 6 weeks after surgery. The SF-36 consists of eight scaled subscores (vitality, physical functioning, bodily pain, general health perceptions, physical role functioning, emotional role functioning, social role functioning, mental Health) and two Component summary scores (physical Component summary scoer, mental component summary score). A score of zero is equivalent to maximum disability and a score of 100 is equivalent to no disability." (NCT02026687)
Timeframe: Preoperatively and until 6 weeks after surgery

,
Interventionunits on a scale (Median)
SF-36 Physical component summary score baselineSF-36 Physical component summary score day 42SF-36 mental component summary score baselineSF-36 mental component summary score day 42
Epidural44394649
Spinal45384651

Reviews

1 review available for clonidine and Genital Neoplasms, Female

ArticleYear
Non-hormonal treatment of vasomotor symptoms in gynecological cancer patients.
    European journal of gynaecological oncology, 2010, Volume: 31, Issue:3

    Topics: Clonidine; Female; Genital Neoplasms, Female; Humans; Phytoestrogens; Selective Serotonin Reuptake I

2010

Trials

1 trial available for clonidine and Genital Neoplasms, Female

ArticleYear
Effect of intrathecal morphine and epidural analgesia on postoperative recovery after abdominal surgery for gynecologic malignancy: an open-label randomised trial.
    BMJ open, 2019, 03-04, Volume: 9, Issue:3

    Topics: Aged; Analgesics, Opioid; Anesthesia, Epidural; Clonidine; Enhanced Recovery After Surgery; Female;

2019