clonidine has been researched along with Genital Neoplasms, Female in 2 studies
Clonidine: An imidazoline sympatholytic agent that stimulates ALPHA-2 ADRENERGIC RECEPTORS and central IMIDAZOLINE RECEPTORS. It is commonly used in the management of HYPERTENSION.
clonidine (amino form) : A clonidine that is 4,5-dihydro-1H-imidazol-2-amine in which one of the amino hydrogens is replaced by a 2,6-dichlorophenyl group.
Genital Neoplasms, Female: Tumor or cancer of the female reproductive tract (GENITALIA, FEMALE).
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kjølhede, P | 1 |
| Bergdahl, O | 1 |
| Borendal Wodlin, N | 1 |
| Nilsson, L | 1 |
| Del Pup, L | 1 |
| Maggino, T | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Will Intrathecal Analgesia Contribute to a Faster Recovery Compared With Epidural Analgesia After Open Surgery for Gynecological Cancer. An Open Controlled Randomized Study.[NCT02026687] | Phase 4 | 80 participants (Actual) | Interventional | 2014-03-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
From day of surgery (Day 0) until discharge after surgery (NCT02026687)
Timeframe: Participants will be followed for the duration of hospital stay, an expected average of 4 days
| Intervention | days (Median) |
|---|---|
| Epidural | 4.3 |
| Spinal | 3.3 |
"Pain at rest will be assessed using a numeric rating scale from 0 (no pain) to 10 (worst imaginable pain). Pain is documented on the day of surgery (day 0), 3 times daily postoperative day 1, 2, 3, 4, 5, 6, 7, 14, 21, 28, 35 and 42.~Scale: NRS Minimum value:0 Maximum value: 10. Higher scores indicate worse outcome." (NCT02026687)
Timeframe: Day of surgery (day 0) until 6 weeks after surgery
| Intervention | units on a scale (Mean) | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Pain at rest Day 0 | Pain at rest Day 1 | Pain at rest Day 2 | Pain at rest Day 3 | Pain at rest Day 4 | Pain at rest Day 5 | Pain at rest Day 6 | Pain at rest Day 7 | Pain at rest Day 14 | Pain at rest Day 21 | Pain at rest Day 28 | Pain at rest Day 35 | Pain at rest Day 42 | |
| Epidural | 1.5 | 1.6 | 1.5 | 2.9 | 1.4 | 1.1 | 1.0 | 1.1 | 0.8 | 0.5 | 0.2 | 0.3 | 0.5 |
| Spinal | 2.7 | 3.2 | 2.1 | 1.4 | 1.6 | 1.2 | 1.1 | 1.0 | 0.7 | 0.3 | 0.2 | 0.3 | 0.1 |
"The questionnaire Short Form with 36 questions SF-36 will be used preoperatively and at 6 weeks after surgery. The SF-36 consists of eight scaled subscores (vitality, physical functioning, bodily pain, general health perceptions, physical role functioning, emotional role functioning, social role functioning, mental Health) and two Component summary scores (physical Component summary scoer, mental component summary score). A score of zero is equivalent to maximum disability and a score of 100 is equivalent to no disability." (NCT02026687)
Timeframe: Preoperatively and until 6 weeks after surgery
| Intervention | units on a scale (Median) | |||
|---|---|---|---|---|
| SF-36 Physical component summary score baseline | SF-36 Physical component summary score day 42 | SF-36 mental component summary score baseline | SF-36 mental component summary score day 42 | |
| Epidural | 44 | 39 | 46 | 49 |
| Spinal | 45 | 38 | 46 | 51 |
1 review available for clonidine and Genital Neoplasms, Female
| Article | Year |
|---|---|
Non-hormonal treatment of vasomotor symptoms in gynecological cancer patients.
Topics: Clonidine; Female; Genital Neoplasms, Female; Humans; Phytoestrogens; Selective Serotonin Reuptake I | 2010 |
1 trial available for clonidine and Genital Neoplasms, Female
| Article | Year |
|---|---|
Effect of intrathecal morphine and epidural analgesia on postoperative recovery after abdominal surgery for gynecologic malignancy: an open-label randomised trial.
Topics: Aged; Analgesics, Opioid; Anesthesia, Epidural; Clonidine; Enhanced Recovery After Surgery; Female; | 2019 |