clonidine has been researched along with Gastric Ulcer in 21 studies
Clonidine: An imidazoline sympatholytic agent that stimulates ALPHA-2 ADRENERGIC RECEPTORS and central IMIDAZOLINE RECEPTORS. It is commonly used in the management of HYPERTENSION.
clonidine (amino form) : A clonidine that is 4,5-dihydro-1H-imidazol-2-amine in which one of the amino hydrogens is replaced by a 2,6-dichlorophenyl group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Clonidine 2 mg/kg ig inhibited the rat gastric ulcers induced by pyloric ligation, stress and indomethacin by 71%, 77% and 82%, respectively." | 7.68 | [Effects of clonidine on experimental stomach ulcer in rats]. ( He, Y; Luo, GY; Tu, LB, 1990) |
| "Effects of tizanidine, a centrally acting muscle relaxant, on gastric acid secretion and gastric ulcers were studied in the rat." | 7.66 | [Influence of a muscle relaxant, tizanidine, on gastric acid secretion and gastric ulcer in rats]. ( Kanaoka, R; Maeda-Hagiwara, M; Watanabe, H; Watanabe, K, 1983) |
| "Tizanidine, an alpha2-adrenergic receptor agonist with myospasmolytic action, is indicated for the treatment of back pain either as monotherapy or in combination with nonsteridal anti-inflammatory drugs (NSAIDs)." | 3.71 | Modulation of NSAID-induced antinociceptive and anti-inflammatory effects by alpha2-adrenoceptor agonists with gastroprotective effects. ( Jain, NK; Kulkarni, SK; Singh, A, 2002) |
| "Clonidine 2 mg/kg ig inhibited the rat gastric ulcers induced by pyloric ligation, stress and indomethacin by 71%, 77% and 82%, respectively." | 3.68 | [Effects of clonidine on experimental stomach ulcer in rats]. ( He, Y; Luo, GY; Tu, LB, 1990) |
| "The antisecretory and gastric ulcer protective effects of clonidine were studied in four different experimental models in rats." | 3.67 | Effect of alpha2 agonists clonidine, guanfacine and B-HT 920 on gastric acid secretion and ulcers in rats. ( Khanna, S; Kulkarni, SK; Kunchandy, J, 1985) |
| "Clonidine and paraaminoclonidine prevented the formation of indomethacin-induced gastric ulcers in female rats." | 3.67 | Antiulcer activity of clonidine: lack of effect on gastric prostaglandins. ( Ben-Zvi, Z; Leibson, V, 1987) |
| "Effects of tizanidine, a centrally acting muscle relaxant, on gastric acid secretion and gastric ulcers were studied in the rat." | 3.66 | [Influence of a muscle relaxant, tizanidine, on gastric acid secretion and gastric ulcer in rats]. ( Kanaoka, R; Maeda-Hagiwara, M; Watanabe, H; Watanabe, K, 1983) |
| "aspirin were additive." | 1.27 | Therapeutic and adjunctive applications of an imidazoline anti-inflammatory agent. ( Holsapple, MP; Nichols, DE; Trizzino, J; Yim, GK, 1983) |
| " The results obtained from these experiments showed that there was no adverse effect and the diuretic and saluretic effects of hydrochlorothiazide were not impaired." | 1.26 | Animal experiments on the safety pharmacology of lofexidine. ( Graf, E; Sieck, A; Wenzl, H; Winkelmann, J, 1982) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 10 (47.62) | 18.7374 |
| 1990's | 5 (23.81) | 18.2507 |
| 2000's | 5 (23.81) | 29.6817 |
| 2010's | 1 (4.76) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Gyires, K | 5 |
| Zádori, Z | 2 |
| Zádori, ZS | 2 |
| Shujaa, N | 2 |
| Al-Khrasani, M | 1 |
| Pap, B | 1 |
| Mózes, MM | 1 |
| Mátyus, P | 1 |
| Brancati, SB | 1 |
| Hein, L | 1 |
| Rónai, AZ | 2 |
| Barna, I | 1 |
| Müllner, K | 1 |
| Reichart, A | 1 |
| Palkovits, M | 1 |
| Jain, NK | 1 |
| Kulkarni, SK | 2 |
| Singh, A | 1 |
| Fülöp, K | 1 |
| Watanabe, K | 1 |
| Watanabe, H | 1 |
| Maeda-Hagiwara, M | 1 |
| Kanaoka, R | 1 |
| Holsapple, MP | 2 |
| Trizzino, J | 1 |
| Nichols, DE | 2 |
| Yim, GK | 2 |
| Graf, E | 1 |
| Sieck, A | 1 |
| Wenzl, H | 1 |
| Winkelmann, J | 1 |
| Chun, A | 1 |
| Lagally, RW | 1 |
| Glavin, GB | 1 |
| Smyth, DD | 1 |
| Yelken, B | 1 |
| Dorman, T | 1 |
| Erkasap, S | 1 |
| Dundar, E | 1 |
| Tanriverdi, B | 1 |
| Gupta, MB | 1 |
| Tangri, KK | 1 |
| Bhargava, KP | 1 |
| D'Souza, RS | 1 |
| Bhandare, PN | 1 |
| Dhume, VG | 1 |
| Luo, GY | 1 |
| He, Y | 1 |
| Tu, LB | 1 |
| Ray, A | 1 |
| Henke, PG | 1 |
| Sullivan, RM | 1 |
| Kunchandy, J | 1 |
| Khanna, S | 1 |
| DiJoseph, JF | 1 |
| Eash, JR | 1 |
| Mir, GN | 1 |
| Del Soldato, P | 1 |
| Ben-Zvi, Z | 1 |
| Leibson, V | 1 |
| Brodie, DA | 1 |
| Hooke, KF | 1 |
21 other studies available for clonidine and Gastric Ulcer
| Article | Year |
|---|---|
[Analysis of central mechanisms involved in gastric mucosal integrity].
Topics: Animals; Arachidonic Acids; beta-Endorphin; Clonidine; Endocannabinoids; Enkephalin, Ala(2)-MePhe(4) | 2008 |
Pharmacological analysis of alpha(2)-adrenoceptor subtypes mediating analgesic, anti-inflammatory and gastroprotective actions.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Agon | 2009 |
Both α2B- and α2C-adrenoceptor subtypes are involved in the mediation of centrally induced gastroprotection in mice.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Animals; Clonidine; E | 2011 |
Gyrus cinguli transection abolishes delta-opioid receptor-induced gastroprotection and alters alpha 2 adrenoceptor activity in the lower brainstem in rats.
Topics: Adrenalectomy; Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-Agonists; Adrenocorticotropic | 2002 |
Modulation of NSAID-induced antinociceptive and anti-inflammatory effects by alpha2-adrenoceptor agonists with gastroprotective effects.
Topics: Adrenergic alpha-Agonists; Animals; Anti-Inflammatory Agents, Non-Steroidal; Clonidine; Drug Synergi | 2002 |
Characterisation of alpha2-adrenoceptor subtypes involved in gastric emptying, gastric motility and gastric mucosal defence.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Clonidine; Disease Models, Animal; | 2005 |
[Influence of a muscle relaxant, tizanidine, on gastric acid secretion and gastric ulcer in rats].
Topics: Anesthesia; Animals; Anti-Ulcer Agents; Bethanechol Compounds; Cimetidine; Clonidine; Dose-Response | 1983 |
Therapeutic and adjunctive applications of an imidazoline anti-inflammatory agent.
Topics: Animals; Anti-Inflammatory Agents; Anti-Ulcer Agents; Aspirin; Carrageenan; Clonidine; Drug Therapy, | 1983 |
Animal experiments on the safety pharmacology of lofexidine.
Topics: Aggression; Anesthetics, Local; Animals; Anticonvulsants; Avoidance Learning; Body Temperature; Cent | 1982 |
Reduction of aspirin-induced ulcers by a new imidazoline anti-inflammatory agent.
Topics: Animals; Anti-Inflammatory Agents; Aspirin; Clonidine; Drug Interactions; Gastric Acid; Male; Mice; | 1981 |
Effects of the selective I1 imidazoline receptor agonist, moxonidine, on gastric secretion and gastric mucosal injury in rats.
Topics: Analysis of Variance; Animals; Antihypertensive Agents; Clonidine; Disease Models, Animal; Ethanol; | 1995 |
Clonidine pretreatment inhibits stress-induced gastric ulcer in rats.
Topics: Adrenocorticotropic Hormone; Animals; Clonidine; Gastric Acid; Gastric Emptying; Hydrocortisone; Lip | 1999 |
Antiulcerogenic activity of clonidine in albino rats.
Topics: Animals; Clonidine; Female; Male; Rats; Stomach Ulcer | 1979 |
Aggravating action of clonidine on ethanol-induced gastric lesions: probable mechanism of action.
Topics: Animals; Cimetidine; Clonidine; Drug Synergism; Ethanol; Male; Naloxone; Phentolamine; Rats; Rats, I | 1990 |
[Effects of clonidine on experimental stomach ulcer in rats].
Topics: Animals; Clonidine; Female; Gastric Acid; Gastric Juice; Male; Pepsin A; Rats; Rats, Inbred Strains; | 1990 |
Noradrenergic mechanisms in the central amygdalar nucleus and gastric stress ulcer formation in rats.
Topics: Adrenergic Fibers; Amygdala; Animals; Clonidine; Male; Microinjections; Norepinephrine; Prazosin; Ra | 1990 |
Effect of alpha2 agonists clonidine, guanfacine and B-HT 920 on gastric acid secretion and ulcers in rats.
Topics: Adrenergic alpha-Agonists; Animals; Anti-Ulcer Agents; Azepines; Clonidine; Female; Gastric Acid; Ga | 1985 |
Gastric antisecretory and antiulcer effects of WHR1582A, a compound exerting alpha-2 adrenoceptor agonist activity.
Topics: Adrenergic alpha-Agonists; Animals; Anti-Ulcer Agents; Aspirin; Carbachol; Clonidine; Cysteamine; Di | 1987 |
Gastric lesion-preventing or -potentiating activity of clonidine in rats.
Topics: Animals; Anti-Ulcer Agents; Atropine; Clonidine; Dimaprit; Female; Ranitidine; Rats; Rats, Inbred St | 1986 |
Antiulcer activity of clonidine: lack of effect on gastric prostaglandins.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Clonidine; Dinoprostone; Female; Gastric Mucosa; Indomethacin | 1987 |
The effect of vasoactive agents on stress-induced gastric hemorrhage in the rat.
Topics: Angiotensin II; Animals; Blood Circulation; Blood Pressure; Clonidine; Cold Temperature; Drug Synerg | 1971 |