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clonidine and Gastric Ulcer

clonidine has been researched along with Gastric Ulcer in 21 studies

Clonidine: An imidazoline sympatholytic agent that stimulates ALPHA-2 ADRENERGIC RECEPTORS and central IMIDAZOLINE RECEPTORS. It is commonly used in the management of HYPERTENSION.
clonidine (amino form) : A clonidine that is 4,5-dihydro-1H-imidazol-2-amine in which one of the amino hydrogens is replaced by a 2,6-dichlorophenyl group.

Research Excerpts

ExcerptRelevanceReference
"Clonidine 2 mg/kg ig inhibited the rat gastric ulcers induced by pyloric ligation, stress and indomethacin by 71%, 77% and 82%, respectively."7.68[Effects of clonidine on experimental stomach ulcer in rats]. ( He, Y; Luo, GY; Tu, LB, 1990)
"Effects of tizanidine, a centrally acting muscle relaxant, on gastric acid secretion and gastric ulcers were studied in the rat."7.66[Influence of a muscle relaxant, tizanidine, on gastric acid secretion and gastric ulcer in rats]. ( Kanaoka, R; Maeda-Hagiwara, M; Watanabe, H; Watanabe, K, 1983)
"Tizanidine, an alpha2-adrenergic receptor agonist with myospasmolytic action, is indicated for the treatment of back pain either as monotherapy or in combination with nonsteridal anti-inflammatory drugs (NSAIDs)."3.71Modulation of NSAID-induced antinociceptive and anti-inflammatory effects by alpha2-adrenoceptor agonists with gastroprotective effects. ( Jain, NK; Kulkarni, SK; Singh, A, 2002)
"Clonidine 2 mg/kg ig inhibited the rat gastric ulcers induced by pyloric ligation, stress and indomethacin by 71%, 77% and 82%, respectively."3.68[Effects of clonidine on experimental stomach ulcer in rats]. ( He, Y; Luo, GY; Tu, LB, 1990)
"The antisecretory and gastric ulcer protective effects of clonidine were studied in four different experimental models in rats."3.67Effect of alpha2 agonists clonidine, guanfacine and B-HT 920 on gastric acid secretion and ulcers in rats. ( Khanna, S; Kulkarni, SK; Kunchandy, J, 1985)
"Clonidine and paraaminoclonidine prevented the formation of indomethacin-induced gastric ulcers in female rats."3.67Antiulcer activity of clonidine: lack of effect on gastric prostaglandins. ( Ben-Zvi, Z; Leibson, V, 1987)
"Effects of tizanidine, a centrally acting muscle relaxant, on gastric acid secretion and gastric ulcers were studied in the rat."3.66[Influence of a muscle relaxant, tizanidine, on gastric acid secretion and gastric ulcer in rats]. ( Kanaoka, R; Maeda-Hagiwara, M; Watanabe, H; Watanabe, K, 1983)
"aspirin were additive."1.27Therapeutic and adjunctive applications of an imidazoline anti-inflammatory agent. ( Holsapple, MP; Nichols, DE; Trizzino, J; Yim, GK, 1983)
" The results obtained from these experiments showed that there was no adverse effect and the diuretic and saluretic effects of hydrochlorothiazide were not impaired."1.26Animal experiments on the safety pharmacology of lofexidine. ( Graf, E; Sieck, A; Wenzl, H; Winkelmann, J, 1982)

Research

Studies (21)

TimeframeStudies, this research(%)All Research%
pre-199010 (47.62)18.7374
1990's5 (23.81)18.2507
2000's5 (23.81)29.6817
2010's1 (4.76)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Gyires, K5
Zádori, Z2
Zádori, ZS2
Shujaa, N2
Al-Khrasani, M1
Pap, B1
Mózes, MM1
Mátyus, P1
Brancati, SB1
Hein, L1
Rónai, AZ2
Barna, I1
Müllner, K1
Reichart, A1
Palkovits, M1
Jain, NK1
Kulkarni, SK2
Singh, A1
Fülöp, K1
Watanabe, K1
Watanabe, H1
Maeda-Hagiwara, M1
Kanaoka, R1
Holsapple, MP2
Trizzino, J1
Nichols, DE2
Yim, GK2
Graf, E1
Sieck, A1
Wenzl, H1
Winkelmann, J1
Chun, A1
Lagally, RW1
Glavin, GB1
Smyth, DD1
Yelken, B1
Dorman, T1
Erkasap, S1
Dundar, E1
Tanriverdi, B1
Gupta, MB1
Tangri, KK1
Bhargava, KP1
D'Souza, RS1
Bhandare, PN1
Dhume, VG1
Luo, GY1
He, Y1
Tu, LB1
Ray, A1
Henke, PG1
Sullivan, RM1
Kunchandy, J1
Khanna, S1
DiJoseph, JF1
Eash, JR1
Mir, GN1
Del Soldato, P1
Ben-Zvi, Z1
Leibson, V1
Brodie, DA1
Hooke, KF1

Other Studies

21 other studies available for clonidine and Gastric Ulcer

ArticleYear
[Analysis of central mechanisms involved in gastric mucosal integrity].
    Neuropsychopharmacologia Hungarica : a Magyar Pszichofarmakologiai Egyesulet lapja = official journal of the Hungarian Association of Psychopharmacology, 2008, Volume: 10, Issue:3

    Topics: Animals; Arachidonic Acids; beta-Endorphin; Clonidine; Endocannabinoids; Enkephalin, Ala(2)-MePhe(4)

2008
Pharmacological analysis of alpha(2)-adrenoceptor subtypes mediating analgesic, anti-inflammatory and gastroprotective actions.
    Inflammopharmacology, 2009, Volume: 17, Issue:3

    Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Agon

2009
Both α2B- and α2C-adrenoceptor subtypes are involved in the mediation of centrally induced gastroprotection in mice.
    European journal of pharmacology, 2011, Nov-01, Volume: 669, Issue:1-3

    Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Animals; Clonidine; E

2011
Gyrus cinguli transection abolishes delta-opioid receptor-induced gastroprotection and alters alpha 2 adrenoceptor activity in the lower brainstem in rats.
    Brain research, 2002, Aug-23, Volume: 947, Issue:1

    Topics: Adrenalectomy; Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-Agonists; Adrenocorticotropic

2002
Modulation of NSAID-induced antinociceptive and anti-inflammatory effects by alpha2-adrenoceptor agonists with gastroprotective effects.
    Life sciences, 2002, May-03, Volume: 70, Issue:24

    Topics: Adrenergic alpha-Agonists; Animals; Anti-Inflammatory Agents, Non-Steroidal; Clonidine; Drug Synergi

2002
Characterisation of alpha2-adrenoceptor subtypes involved in gastric emptying, gastric motility and gastric mucosal defence.
    European journal of pharmacology, 2005, Dec-28, Volume: 528, Issue:1-3

    Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Clonidine; Disease Models, Animal;

2005
[Influence of a muscle relaxant, tizanidine, on gastric acid secretion and gastric ulcer in rats].
    Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 1983, Volume: 82, Issue:4

    Topics: Anesthesia; Animals; Anti-Ulcer Agents; Bethanechol Compounds; Cimetidine; Clonidine; Dose-Response

1983
Therapeutic and adjunctive applications of an imidazoline anti-inflammatory agent.
    The Journal of pharmacology and experimental therapeutics, 1983, Volume: 224, Issue:3

    Topics: Animals; Anti-Inflammatory Agents; Anti-Ulcer Agents; Aspirin; Carrageenan; Clonidine; Drug Therapy,

1983
Animal experiments on the safety pharmacology of lofexidine.
    Arzneimittel-Forschung, 1982, Volume: 32, Issue:8a

    Topics: Aggression; Anesthetics, Local; Animals; Anticonvulsants; Avoidance Learning; Body Temperature; Cent

1982
Reduction of aspirin-induced ulcers by a new imidazoline anti-inflammatory agent.
    Agents and actions, 1981, Volume: 11, Issue:6-7

    Topics: Animals; Anti-Inflammatory Agents; Aspirin; Clonidine; Drug Interactions; Gastric Acid; Male; Mice;

1981
Effects of the selective I1 imidazoline receptor agonist, moxonidine, on gastric secretion and gastric mucosal injury in rats.
    British journal of pharmacology, 1995, Volume: 114, Issue:4

    Topics: Analysis of Variance; Animals; Antihypertensive Agents; Clonidine; Disease Models, Animal; Ethanol;

1995
Clonidine pretreatment inhibits stress-induced gastric ulcer in rats.
    Anesthesia and analgesia, 1999, Volume: 89, Issue:1

    Topics: Adrenocorticotropic Hormone; Animals; Clonidine; Gastric Acid; Gastric Emptying; Hydrocortisone; Lip

1999
Antiulcerogenic activity of clonidine in albino rats.
    The Indian journal of medical research, 1979, Volume: 70

    Topics: Animals; Clonidine; Female; Male; Rats; Stomach Ulcer

1979
Aggravating action of clonidine on ethanol-induced gastric lesions: probable mechanism of action.
    Indian journal of physiology and pharmacology, 1990, Volume: 34, Issue:4

    Topics: Animals; Cimetidine; Clonidine; Drug Synergism; Ethanol; Male; Naloxone; Phentolamine; Rats; Rats, I

1990
[Effects of clonidine on experimental stomach ulcer in rats].
    Zhongguo yao li xue bao = Acta pharmacologica Sinica, 1990, Volume: 11, Issue:5

    Topics: Animals; Clonidine; Female; Gastric Acid; Gastric Juice; Male; Pepsin A; Rats; Rats, Inbred Strains;

1990
Noradrenergic mechanisms in the central amygdalar nucleus and gastric stress ulcer formation in rats.
    Neuroscience letters, 1990, Mar-14, Volume: 110, Issue:3

    Topics: Adrenergic Fibers; Amygdala; Animals; Clonidine; Male; Microinjections; Norepinephrine; Prazosin; Ra

1990
Effect of alpha2 agonists clonidine, guanfacine and B-HT 920 on gastric acid secretion and ulcers in rats.
    Archives internationales de pharmacodynamie et de therapie, 1985, Volume: 275, Issue:1

    Topics: Adrenergic alpha-Agonists; Animals; Anti-Ulcer Agents; Azepines; Clonidine; Female; Gastric Acid; Ga

1985
Gastric antisecretory and antiulcer effects of WHR1582A, a compound exerting alpha-2 adrenoceptor agonist activity.
    The Journal of pharmacology and experimental therapeutics, 1987, Volume: 241, Issue:1

    Topics: Adrenergic alpha-Agonists; Animals; Anti-Ulcer Agents; Aspirin; Carbachol; Clonidine; Cysteamine; Di

1987
Gastric lesion-preventing or -potentiating activity of clonidine in rats.
    Japanese journal of pharmacology, 1986, Volume: 41, Issue:2

    Topics: Animals; Anti-Ulcer Agents; Atropine; Clonidine; Dimaprit; Female; Ranitidine; Rats; Rats, Inbred St

1986
Antiulcer activity of clonidine: lack of effect on gastric prostaglandins.
    Prostaglandins, leukotrienes, and medicine, 1987, Volume: 30, Issue:1

    Topics: 6-Ketoprostaglandin F1 alpha; Animals; Clonidine; Dinoprostone; Female; Gastric Mucosa; Indomethacin

1987
The effect of vasoactive agents on stress-induced gastric hemorrhage in the rat.
    Digestion, 1971, Volume: 4, Issue:4

    Topics: Angiotensin II; Animals; Blood Circulation; Blood Pressure; Clonidine; Cold Temperature; Drug Synerg

1971