clonidine has been researched along with Flaccid Quadriplegia in 10 studies
Clonidine: An imidazoline sympatholytic agent that stimulates ALPHA-2 ADRENERGIC RECEPTORS and central IMIDAZOLINE RECEPTORS. It is commonly used in the management of HYPERTENSION.
clonidine (amino form) : A clonidine that is 4,5-dihydro-1H-imidazol-2-amine in which one of the amino hydrogens is replaced by a 2,6-dichlorophenyl group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Tizanidine is a centrally acting alpha-2 adrenoreceptor agonist widely used in the treatment of spasticity in patients with cerebral or spinal injury, and it is causing drawsiness in some of them." | 2.71 | [Effects of tizanidine for refractory sleep disturbance in disabled children with spastic quadriplegia]. ( Cho, K; Fujieda, K; Fukuda, I; Miyamoto, A; Oka, R; Tanaka, H, 2004) |
| "Severe muscle hypertonia in patients with the mixed type of tetraplegia may be associated with significant deterioration in the quality of life of the patients." | 1.42 | [Effectiveness of continuous infusion of tizanidine (Ternelin) via a feeding tube for patients with the mixed type of tetraplegia]. ( Fujii, T; Hayasi, A; Hiejima, I; Kumada, T; Miyajima, T; Nozaki, F, 2015) |
| "Significant improvement in spastic hypertonia was observed in all three cases." | 1.29 | Effect of transdermal clonidine on spinal spasticity. A case series. ( Sipski, ML; Yablon, SA, 1993) |
| "When clonidine therapy was initiated, the patient responded rapidly with both subjective and objective improvements in her spasticity." | 1.28 | Clonidine in the treatment of brainstem spasticity. Case report. ( Sandford, PR; Sawasky, KB; Spengler, SE, 1992) |
| "Five patients had no change in clinical spasticity (average dose of 0." | 1.27 | Early clinical experience with clonidine in spinal spasticity. ( Maynard, FM, 1986) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (50.00) | 18.7374 |
| 1990's | 3 (30.00) | 18.2507 |
| 2000's | 1 (10.00) | 29.6817 |
| 2010's | 1 (10.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Hiejima, I | 1 |
| Kumada, T | 1 |
| Nozaki, F | 1 |
| Hayasi, A | 1 |
| Miyajima, T | 1 |
| Fujii, T | 1 |
| Tanaka, H | 1 |
| Fukuda, I | 1 |
| Miyamoto, A | 1 |
| Oka, R | 1 |
| Cho, K | 1 |
| Fujieda, K | 1 |
| Yablon, SA | 1 |
| Sipski, ML | 1 |
| Reid, JL | 2 |
| Wing, LM | 2 |
| Mathias, CJ | 5 |
| Frankel, HL | 5 |
| Neill, E | 1 |
| Christensen, NJ | 1 |
| Sandford, PR | 1 |
| Spengler, SE | 1 |
| Sawasky, KB | 1 |
| Kooner, JS | 3 |
| Birch, R | 2 |
| Peart, WS | 3 |
| Edge, W | 1 |
| Stone, F | 1 |
| Maynard, FM | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Hemodynamic Effect of Intrathecal Clonidine in Hypertensive Subjects: A Pilot Study to Assess Its Effectiveness in Hypertensive Subjects With Poor Blood Pressure Control (Phase II)[NCT01297335] | Phase 2 | 10 participants (Actual) | Interventional | 2011-02-28 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
"Subjects baseline blood pressure (systolic blood pressure (SBP), and diastolic blood pressure (DBP)), and blood pressures after clonidine injection was compared against baseline to assess efficacy of clonidine in refractory hypertensive subjects. Subject's blood pressure was monitored continuously after intrathecal injection of clonidine until subjects blood pressure nadir and return to pre clonidine injection level. The mean value reported below are the average changes in blood pressure from baseline (pre clonidine injection) in both SBP and DBP during post clonidine injection blood pressure monitoring for 4 hours.~Blood pressure measurements were collected every 10 minutes for first hour after injection, and every 15 minutes after the first hour, up to 4 hours were averaged to report the change from baseline." (NCT01297335)
Timeframe: Baseline, Every 10 Minutes for first hour after clonidine injection, and every 15 minutes after first hour, until 4 hours after clonidine injection
| Intervention | mm Hg (Mean) | |
|---|---|---|
| Change in mean SBP after clonidine injection | Change in DBP after clonidine injection | |
| Intrathecal Clonidine | 79 | 37 |
Subjects were asked to rate severity of two of the most common side effects of clonidine, sedation and sensation of dry mouth, at pre and post (1 hour after) intrathecal administration of clonidine. The mean changes between pre and post injection VAS ratings of sedation and sensation of dry mouth are reported below. The VAS scale ranges from 1 to 10 cm, with higher values indicating higher level of sedation and higher level of dry mouth. (NCT01297335)
Timeframe: Before clonidine injection (Baseline), and at 1 hour after clonidine injection.
| Intervention | cm (Mean) | |
|---|---|---|
| Change in level of sedation | Change in sensation of dry mouth | |
| Intrathecal Clonidine | 3.36 | 3.47 |
Likert scale is 11 point digital pain rating system that asks subjects to rate their pain from 0 to 10. Rating of 0 means no pain at all, and in increasing order, 10 would mean worst pain imaginable/ unbearable pain. (NCT01297335)
Timeframe: Pre-dose and 1 hour post injection.
| Intervention | units on a scale (Mean) | |
|---|---|---|
| Pre-injection average Likert score | Post-injection average Likert score | |
| Intrathecal Clonidine | 6.5 | 3.6 |
2 trials available for clonidine and Flaccid Quadriplegia
| Article | Year |
|---|---|
[Effects of tizanidine for refractory sleep disturbance in disabled children with spastic quadriplegia].
Topics: Adolescent; Adrenergic alpha-Agonists; Adult; Child; Child, Preschool; Clonidine; Disabled Children; | 2004 |
The central hypotensive effect of clonidine. Studies in tetraplegic subjects.
Topics: Adult; Blood Pressure; Brain; Clinical Trials as Topic; Clonidine; Half-Life; Heart Rate; Humans; Hy | 1977 |
8 other studies available for clonidine and Flaccid Quadriplegia
| Article | Year |
|---|---|
[Effectiveness of continuous infusion of tizanidine (Ternelin) via a feeding tube for patients with the mixed type of tetraplegia].
Topics: Child, Preschool; Clonidine; Enteral Nutrition; Female; Humans; Infant; Male; Muscle Hypertonia; Mus | 2015 |
Effect of transdermal clonidine on spinal spasticity. A case series.
Topics: Administration, Cutaneous; Adolescent; Adult; Clonidine; Female; Humans; Male; Muscle Hypertonia; Mu | 1993 |
Antihypertensive effects of clonidine in tetraplegic subjects devoid of central sympathetic control.
Topics: Adult; Antihypertensive Agents; Blood Pressure; Clonidine; Heart Rate; Humans; Hypertension; Male; M | 1979 |
Clonidine in the treatment of brainstem spasticity. Case report.
Topics: Adult; Baclofen; Cerebral Infarction; Clonidine; Female; Humans; Medulla Oblongata; Muscle Spasticit | 1992 |
Hemodynamic and neurohormonal effects of clonidine in patients with preganglionic and postganglionic sympathetic lesions. Evidence for a central sympatholytic action.
Topics: Adolescent; Adult; Aorta; Blood Flow Velocity; Blood Pressure; Body Temperature; Brachial Plexus; Cl | 1991 |
Haemodynamic actions of clonidine in tetraplegia--effects at rest and during urinary bladder stimulation.
Topics: Adolescent; Adult; Clonidine; Hemodynamics; Humans; Immobilization; Infusions, Intravenous; Middle A | 1988 |
Vascular effects of clonidine in patients with tetraplegia and unilateral brachial plexus injury.
Topics: Adult; Brachial Plexus; Clonidine; Female; Hemodynamics; Humans; Male; Middle Aged; Quadriplegia | 1988 |
Early clinical experience with clonidine in spinal spasticity.
Topics: Adult; Aged; Clonidine; Female; Humans; Male; Muscle Spasticity; Quadriplegia | 1986 |