clonidine has been researched along with Epilepsy in 19 studies
Clonidine: An imidazoline sympatholytic agent that stimulates ALPHA-2 ADRENERGIC RECEPTORS and central IMIDAZOLINE RECEPTORS. It is commonly used in the management of HYPERTENSION.
clonidine (amino form) : A clonidine that is 4,5-dihydro-1H-imidazol-2-amine in which one of the amino hydrogens is replaced by a 2,6-dichlorophenyl group.
Epilepsy: A disorder characterized by recurrent episodes of paroxysmal brain dysfunction due to a sudden, disorderly, and excessive neuronal discharge. Epilepsy classification systems are generally based upon: (1) clinical features of the seizure episodes (e.g., motor seizure), (2) etiology (e.g., post-traumatic), (3) anatomic site of seizure origin (e.g., frontal lobe seizure), (4) tendency to spread to other structures in the brain, and (5) temporal patterns (e.g., nocturnal epilepsy). (From Adams et al., Principles of Neurology, 6th ed, p313)
| Excerpt | Relevance | Reference |
|---|---|---|
| " In cobalt-induced epilepsy in the rat activity is associated with a cortical NA denervation." | 8.77 | Chronic cobalt-induced epilepsy: noradrenaline ionophoresis and adrenoceptor binding studies in the rat cerebral cortex. ( Bregman, B; Chauvel, P; Le Saux, F; Maurin, Y; Trottier, S, 1985) |
| "Focal and convulsive seizure thresholds were evaluated 10-12 min postinfusion and compared to thresholds obtained during two interspersed control conditions (vehicle control = 1 microliter microinfusion of sterile saline; sham control = needle insertion only)." | 5.29 | The alpha 2-adrenoreceptor agonist clonidine suppresses seizures, whereas the alpha 2-adrenoreceptor antagonist idazoxan promotes seizures in amygdala-kindled kittens: a comparison of amygdala and pontine microinfusion effects. ( Alcalde, O; Bier, M; Farber, PR; Langer, J; Moghimi, R; Richkind, M; Shouse, MN; Szymusiak, R, 1996) |
| " In cobalt-induced epilepsy in the rat activity is associated with a cortical NA denervation." | 4.77 | Chronic cobalt-induced epilepsy: noradrenaline ionophoresis and adrenoceptor binding studies in the rat cerebral cortex. ( Bregman, B; Chauvel, P; Le Saux, F; Maurin, Y; Trottier, S, 1985) |
| "We have investigated the influence of central noradrenergic and dopaminergic systems on the susceptibility of rats to seizures in the kainic acid (KA)-model of epilepsy." | 3.67 | Kainic acid-induced seizures: potentiation by alpha-methyl-p-tyrosine. ( Baran, H; Hornykiewicz, O; Hörtnagl, H, 1989) |
| "We found that the binding of [3H]prazosin, a selective ligand for alpha 1-adrenergic recognition sites, is significantly lower in the frontal cortex of the genetically epilepsy-prone rats (GEPRs), as compared with normal Sprague-Dawley rats." | 3.67 | Abnormality of alpha 1-adrenergic receptors in the frontal cortex of epileptic rats. ( Barbaccia, ML; Iadarola, MJ; Laird, HE; Nicoletti, F; Pozzi, O, 1986) |
| "Clonidine was the most common medication to be used and was well tolerated." | 1.48 | Implications of comorbid ADHD in ASD interventions and outcome: Results from a naturalistic follow up study from south India. ( Chandrasekaran, V; Kandasamy, P; Kuppili, PP; Manohar, H; Rajkumar, RP, 2018) |
| "Clonidine was most effective in temporal lobe epilepsy, when the focus was located in the right hemisphere, and when clonidine serum concentrations were ranging between 0." | 1.33 | Comparison of clonidine to sleep deprivation in the potential to induce spike or sharp-wave activity. ( Feichtinger, M; Hummel, C; Kaltenhäuser, M; Kettenmann, B; Stefan, H; Tilz, C, 2005) |
| "Pharmacological treatment of epilepsy is needed whenever epilepsy occurs." | 1.31 | [Medical treatment of fragile X syndrome]. ( Artigas-Pallarés, J; Brun-Gasca, C, 2001) |
| "Focal and convulsive seizure thresholds were evaluated 10-12 min postinfusion and compared to thresholds obtained during two interspersed control conditions (vehicle control = 1 microliter microinfusion of sterile saline; sham control = needle insertion only)." | 1.29 | The alpha 2-adrenoreceptor agonist clonidine suppresses seizures, whereas the alpha 2-adrenoreceptor antagonist idazoxan promotes seizures in amygdala-kindled kittens: a comparison of amygdala and pontine microinfusion effects. ( Alcalde, O; Bier, M; Farber, PR; Langer, J; Moghimi, R; Richkind, M; Shouse, MN; Szymusiak, R, 1996) |
| "Pretreatment with reserpine had no effect on either the time to onset or duration of maximal dentate activation." | 1.28 | Cholinergic and adrenergic agents modify the initiation and termination of epileptic discharges in the dentate gyrus. ( Lothman, EW; Stringer, JL, 1991) |
| " These findings were confirmed and extended here with dose-response curves." | 1.28 | Neonatal clonidine treatment results in long-lasting changes in noradrenaline sensitivity and kindling epileptogenesis. ( Bos, NP; Gorter, JA; Huisman, E; Kamphuis, W; Mirmiran, M, 1990) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (26.32) | 18.7374 |
| 1990's | 7 (36.84) | 18.2507 |
| 2000's | 5 (26.32) | 29.6817 |
| 2010's | 2 (10.53) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Manohar, H | 1 |
| Kuppili, PP | 1 |
| Kandasamy, P | 1 |
| Chandrasekaran, V | 1 |
| Rajkumar, RP | 1 |
| Vorobyov, V | 1 |
| Schibaev, N | 1 |
| Kaptsov, V | 1 |
| Kovalev, G | 1 |
| Sengpiel, F | 1 |
| Artigas-Pallarés, J | 1 |
| Brun-Gasca, C | 1 |
| Kettenmann, B | 1 |
| Feichtinger, M | 1 |
| Tilz, C | 1 |
| Kaltenhäuser, M | 1 |
| Hummel, C | 1 |
| Stefan, H | 1 |
| Shouse, MN | 1 |
| Langer, J | 1 |
| Bier, M | 1 |
| Farber, PR | 1 |
| Alcalde, O | 1 |
| Moghimi, R | 1 |
| Richkind, M | 1 |
| Szymusiak, R | 1 |
| Yoshioka, S | 1 |
| Mitani, H | 1 |
| Maeda, K | 1 |
| Takeo, S | 1 |
| Matsuda, K | 1 |
| Katayama, S | 1 |
| Mizukawa, R | 1 |
| Kawahara, R | 1 |
| Scaramuzza, A | 1 |
| Torresani, P | 1 |
| Arisi, D | 1 |
| Rossoni, R | 1 |
| Niederhofer, H | 1 |
| Metz, SA | 1 |
| Halter, JB | 1 |
| Porte, D | 1 |
| Robertson, RP | 1 |
| Chen, LS | 1 |
| Weingart, JB | 1 |
| McNamara, JO | 1 |
| Lehmenkühler, C | 1 |
| Walden, J | 1 |
| Speckmann, EJ | 1 |
| Stringer, JL | 1 |
| Lothman, EW | 1 |
| Gorter, JA | 1 |
| Kamphuis, W | 1 |
| Huisman, E | 1 |
| Bos, NP | 1 |
| Mirmiran, M | 1 |
| Baran, H | 1 |
| Hörtnagl, H | 1 |
| Hornykiewicz, O | 1 |
| Löscher, W | 1 |
| Czuczwar, SJ | 1 |
| Nicoletti, F | 1 |
| Barbaccia, ML | 1 |
| Iadarola, MJ | 1 |
| Pozzi, O | 1 |
| Laird, HE | 1 |
| Bregman, B | 1 |
| Le Saux, F | 1 |
| Trottier, S | 1 |
| Chauvel, P | 1 |
| Maurin, Y | 1 |
1 review available for clonidine and Epilepsy
| Article | Year |
|---|---|
Chronic cobalt-induced epilepsy: noradrenaline ionophoresis and adrenoceptor binding studies in the rat cerebral cortex.
Topics: Animals; Cerebral Cortex; Chronic Disease; Clonidine; Cobalt; Dihydroalprenolol; Epilepsy; Iontophor | 1985 |
18 other studies available for clonidine and Epilepsy
| Article | Year |
|---|---|
Implications of comorbid ADHD in ASD interventions and outcome: Results from a naturalistic follow up study from south India.
Topics: Adrenergic alpha-2 Receptor Agonists; Attention Deficit Disorder with Hyperactivity; Autism Spectrum | 2018 |
Cortical and hippocampal EEG effects of neurotransmitter agonists in spontaneously hypertensive vs. kainate-treated rats.
Topics: Animals; Attention Deficit Disorder with Hyperactivity; Baclofen; Clonidine; Disease Models, Animal; | 2011 |
[Medical treatment of fragile X syndrome].
Topics: Adrenergic alpha-Agonists; Anticonvulsants; Antipsychotic Agents; Attention Deficit and Disruptive B | 2001 |
Comparison of clonidine to sleep deprivation in the potential to induce spike or sharp-wave activity.
Topics: Action Potentials; Adolescent; Adult; Clonidine; Epilepsy; Female; Humans; Magnetoencephalography; M | 2005 |
The alpha 2-adrenoreceptor agonist clonidine suppresses seizures, whereas the alpha 2-adrenoreceptor antagonist idazoxan promotes seizures in amygdala-kindled kittens: a comparison of amygdala and pontine microinfusion effects.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Amygdala; Animals; Cats; Clonidine; Dioxane | 1996 |
[Current data on bipolar disorders, epilepsy and spasticity. 4. Neuro-Forum, Dresden].
Topics: Baclofen; Bipolar Disorder; Clonidine; Epilepsy; Female; Humans; Male; Muscle Relaxants, Central; Mu | 1999 |
[Current data on bipolar disorders, epilepsy and spasm. 4th Neuro-Forum, Dresden].
Topics: Baclofen; Benzodiazepines; Bipolar Disorder; Clonidine; Epilepsy; Humans; Muscle Relaxants, Central; | 1999 |
Age-specific effects of noradrenergic alpha-2 agonist clonidine on the development of amygdaloid kindling in developing rats.
Topics: Adrenergic alpha-Agonists; Aging; Amygdala; Animals; Anticonvulsants; Clonidine; Convulsants; Epilep | 2000 |
Seizures following clonidine test for growth hormone reserve: unusual presentation of benign partial epilepsy.
Topics: Child; Clonidine; Electroencephalography; Epilepsy; Human Growth Hormone; Humans; Magnetic Resonance | 2000 |
[Therapy of tic disorders apparently of organic origin in a multi-morbid 5-year-old patient with lofexidine (Britlofex) and clonidine (Catapressan)].
Topics: Affective Symptoms; Aggression; Attention Deficit Disorder with Hyperactivity; Brain Damage, Chronic | 2001 |
Autonomic epilepsy: clonidine blockade of paroxysmal catecholamine release and flushing.
Topics: Autonomic Nervous System; Carbamazepine; Catecholamines; Climacteric; Clonidine; Epilepsy; Epilepsy, | 1978 |
Biochemical and radiohistochemical analyses of alpha-2 adrenergic receptors in the kindling model of epilepsy.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Autoradiography; Brain; Cell Membr | 1990 |
Decrease of N-methyl-D-aspartate responses by noradrenaline in the rat motorcortex in vivo.
Topics: Animals; Clonidine; Electroencephalography; Epilepsy; Evoked Potentials; Isoproterenol; Motor Cortex | 1991 |
Cholinergic and adrenergic agents modify the initiation and termination of epileptic discharges in the dentate gyrus.
Topics: Animals; Atropine; Clonidine; Electric Stimulation; Epilepsy; Hippocampus; Male; Parasympathomimetic | 1991 |
Neonatal clonidine treatment results in long-lasting changes in noradrenaline sensitivity and kindling epileptogenesis.
Topics: Animals; Animals, Newborn; Clonidine; Electric Stimulation; Epilepsy; Iontophoresis; Kindling, Neuro | 1990 |
Kainic acid-induced seizures: potentiation by alpha-methyl-p-tyrosine.
Topics: alpha-Methyltyrosine; Animals; Clonidine; Diazepam; Dopamine; Epilepsy; Kainic Acid; Male; Methyltyr | 1989 |
Comparison of drugs with different selectivity for central alpha 1-and alpha 2-adrenoceptors in animal models of epilepsy.
Topics: Animals; Clonidine; Disease Models, Animal; Dose-Response Relationship, Drug; Electric Stimulation; | 1987 |
Abnormality of alpha 1-adrenergic receptors in the frontal cortex of epileptic rats.
Topics: Animals; Carbachol; Cerebral Cortex; Clonidine; Dose-Response Relationship, Drug; Epilepsy; Hippocam | 1986 |