clonidine has been researched along with Epilepsy, Tonic-Clonic in 2 studies
Clonidine: An imidazoline sympatholytic agent that stimulates ALPHA-2 ADRENERGIC RECEPTORS and central IMIDAZOLINE RECEPTORS. It is commonly used in the management of HYPERTENSION.
clonidine (amino form) : A clonidine that is 4,5-dihydro-1H-imidazol-2-amine in which one of the amino hydrogens is replaced by a 2,6-dichlorophenyl group.
Epilepsy, Tonic-Clonic: A generalized seizure disorder characterized by recurrent major motor seizures. The initial brief tonic phase is marked by trunk flexion followed by diffuse extension of the trunk and extremities. The clonic phase features rhythmic flexor contractions of the trunk and limbs, pupillary dilation, elevations of blood pressure and pulse, urinary incontinence, and tongue biting. This is followed by a profound state of depressed consciousness (post-ictal state) which gradually improves over minutes to hours. The disorder may be cryptogenic, familial, or symptomatic (caused by an identified disease process). (From Adams et al., Principles of Neurology, 6th ed, p329)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Focal and convulsive seizure thresholds were evaluated 10-12 min post-infusion and compared to thresholds obtained during two, interspersed control conditions (vehicle control: 1 microliter microinfusion of sterile saline; sham control: needle insertion only)." | 5.29 | The alpha 2-agonist clonidine suppresses seizures, whereas the alpha 2-antagonist idazoxan promotes seizures--a microinfusion study in amygdala-kindled kittens. ( Alcalde, O; Bier, M; Langer, J; Richkind, M; Shouse, MN; Szymusiak, R, 1994) |
| "Focal and convulsive seizure thresholds were evaluated 10-12 min post-infusion and compared to thresholds obtained during two, interspersed control conditions (vehicle control: 1 microliter microinfusion of sterile saline; sham control: needle insertion only)." | 1.29 | The alpha 2-agonist clonidine suppresses seizures, whereas the alpha 2-antagonist idazoxan promotes seizures--a microinfusion study in amygdala-kindled kittens. ( Alcalde, O; Bier, M; Langer, J; Richkind, M; Shouse, MN; Szymusiak, R, 1994) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (50.00) | 18.2507 |
| 2000's | 1 (50.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Shouse, MN | 1 |
| Bier, M | 1 |
| Langer, J | 1 |
| Alcalde, O | 1 |
| Richkind, M | 1 |
| Szymusiak, R | 1 |
| Yochelson, MR | 1 |
| David, RG | 1 |
2 other studies available for clonidine and Epilepsy, Tonic-Clonic
| Article | Year |
|---|---|
The alpha 2-agonist clonidine suppresses seizures, whereas the alpha 2-antagonist idazoxan promotes seizures--a microinfusion study in amygdala-kindled kittens.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Amygdala; Animals; An | 1994 |
New-onset tic disorder following acute hemorrhage of an arteriovenous malformation.
Topics: Acute Disease; Adolescent; Adrenergic alpha-Agonists; Cerebral Hemorrhage; Clonidine; Craniotomy; Di | 2000 |