Page last updated: 2024-10-25

clonidine and Emesis, Postoperative

clonidine has been researched along with Emesis, Postoperative in 39 studies

Clonidine: An imidazoline sympatholytic agent that stimulates ALPHA-2 ADRENERGIC RECEPTORS and central IMIDAZOLINE RECEPTORS. It is commonly used in the management of HYPERTENSION.
clonidine (amino form) : A clonidine that is 4,5-dihydro-1H-imidazol-2-amine in which one of the amino hydrogens is replaced by a 2,6-dichlorophenyl group.

Research Excerpts

ExcerptRelevanceReference
"We evaluated the effect of oral clonidine on postoperative vomiting (POV) in children undergoing strabismus surgery."9.10Oral clonidine premedication does not reduce postoperative vomiting in children undergoing strabismus surgery. ( Durmus, M; Ersoy, MO; Gedik, E; Gulhas, N; Togal, T; Turkoz, A, 2003)
" Our hypothesis is that coinduction with clonidine reduces the incidence of PONV in adult patients undergoing breast cancer surgery."9.10Effects of clonidine on postoperative nausea and vomiting in breast cancer surgery. ( Bergendahl, HT; Eksborg, S; Lönnqvist, PA; Muhrbeck, O; Oddby-Muhrbeck, E, 2002)
"We evaluated the efficacy of clonidine given orally preoperatively for preventing postoperative vomiting (POV) in children undergoing propofol-nitrous oxide anaesthesia for strabismus surgery."9.09The efficacy of oral clonidine premedication in the prevention of postoperative vomiting in children following strabismus surgery. ( Fujii, Y; Handa, F, 2001)
"Clonidine appears a safe and beneficial drug with moderate to high-quality evidence supporting its use in pediatric anesthesia."9.01Clonidine in pediatric anesthesia: the new panacea or a drug still looking for an indication? ( Afshari, A, 2019)
"Intrathecal morphine (ITM) is a widely used technique for postcaesarean section analgesia but entails a high risk of postoperative nausea and vomiting (PONV)."5.30The impact of a transversus abdominis plane block including clonidine vs. intrathecal morphine on nausea and vomiting after caesarean section: A randomised controlled trial. ( Combescure, C; Dereu, D; Mathivon, S; Mercier, Y; Rehberg, B; Savoldelli, GL, 2019)
"In 139 patients anxiety, sedation and adverse effects were measured at 6 consecutive perioperative time points after administration of midazolam, clonidine or a placebo."5.14[Quality of premedication and patient satisfaction after premedication with midazolam, clonidine or placebo : Randomized double-blind study with age-adjusted dosage]. ( Ivleva-Sauerborn, A; Seifert, B; Spahn, DR; Zalunardo, MP, 2010)
" The addition of clonidine 2 microg/kg to bupivacaine provides a prolonged anesthetic action but may be associated with hypotension."5.12Clonidine 1 microg/kg is a safe and effective adjuvant to plain bupivacaine in spinal anesthesia in adolescents. ( Abdelaziz, AB; Chattaoui, O; Kaabachi, O; Kokki, H; Ouezini, R; Zarghouni, A, 2007)
"We evaluated the effect of oral clonidine on postoperative vomiting (POV) in children undergoing strabismus surgery."5.10Oral clonidine premedication does not reduce postoperative vomiting in children undergoing strabismus surgery. ( Durmus, M; Ersoy, MO; Gedik, E; Gulhas, N; Togal, T; Turkoz, A, 2003)
" In the postoperative period the incidence of postoperative nausea and vomiting (PONV) (ND: n = 8, HD: n = 2, midazolam: n = 6) and the use of pritramid were lower in the clonidine HD group (HD: 38."5.10[Comparison of premedication with clonidine and midazolam combined with TCI for orthopaedic shoulder surgery]. ( Dietrich, PJ; Grottke, O; Krause, TH; Müller, J; Wappler, F, 2003)
" Our hypothesis is that coinduction with clonidine reduces the incidence of PONV in adult patients undergoing breast cancer surgery."5.10Effects of clonidine on postoperative nausea and vomiting in breast cancer surgery. ( Bergendahl, HT; Eksborg, S; Lönnqvist, PA; Muhrbeck, O; Oddby-Muhrbeck, E, 2002)
"We evaluated the efficacy of clonidine given orally preoperatively for preventing postoperative vomiting (POV) in children undergoing propofol-nitrous oxide anaesthesia for strabismus surgery."5.09The efficacy of oral clonidine premedication in the prevention of postoperative vomiting in children following strabismus surgery. ( Fujii, Y; Handa, F, 2001)
"Clonidine appears a safe and beneficial drug with moderate to high-quality evidence supporting its use in pediatric anesthesia."5.01Clonidine in pediatric anesthesia: the new panacea or a drug still looking for an indication? ( Afshari, A, 2019)
"Compared with control intervention, clonidine intervention was found to significantly reduce MAP and HR at pneumoperitoneum and intubation, propofol requirement, as well as postoperative nausea and vomiting in patients undergoing laparoscopic cholecystectomy."4.95Effect of Clonidine on Hemodynamic Responses During Laparoscopic Cholecystectomy: A Systematic Review and Meta-Analysis. ( Wang, Y; Zhang, J; Zhang, X; Zhang, Y, 2017)
" A continuous low dose IV midazolam infusion was added to his treatment regimen (as is instituted for recalcitrant postoperative nausea and vomiting) with benefit, but not total symptom resolution."3.73Use of intravenous midazolam and clonidine in cyclical vomiting syndrome: a case report. ( Cameron, DJ; Palmer, GM, 2005)
"The incidence of postoperative nausea in women was more than men (p=0."2.87Comparison of Ondansetron versus Clonidine efficacy for prevention of postoperative pain, nausea and vomiting after orthognathic surgeries: A triple blind randomized controlled trial. ( Eshghpour, M; Hashemipour, MS; Hosseini-Abrishami, M; Mianbandi, V; Samieirad, S; Shadkam, E; Sharifian-Attar, A, 2018)
"Clonidine has been shown to reduce intraoperative haemodynamic instability."2.84Role of Oral Clonidine Premedication on Intra-operative Haemodynamics and PONV in Laparoscopic Cholecystectomy. ( Banik, D; Haque, AK; Jahan, S; Masud, M; Saha, NC; Yeasmeen, S, 2017)
"Melatonin was effective for steal induction in 75% of children compared to 88% of children who had clonidine."2.78Steal induction in preschool children: is melatonin as good as clonidine? A prospective, randomized study. ( Almenrader, N; Haiberger, R; Passariello, M, 2013)
"Clonidine has the potential to significantly prolong the duration of caudal epidural anesthesia."2.76Effect of epidural clonidine on minimum local anesthetic concentration (ED50) of levobupivacaine for caudal block in children. ( Alberighi, OD; Disma, N; Frawley, G; Mameli, L; Montobbio, G; Pistorio, A; Tuo, P, 2011)
"Clonidine is an alpha(2) adrenoreceptor and imidazoline receptor agonist, which has analgesic, sedative, and minimum alveolar anesthetic concentration-sparing effects."2.74The analgesic effect of epidural clonidine after spinal surgery: a randomized placebo-controlled trial. ( Farmery, AD; Wilson-MacDonald, J, 2009)
"Spinal anesthesia with supplemental epidural clonidine in combination with incision site subcutaneous bupivacaine was evaluated both intra- and postoperatively and compared with spinal anesthesia alone for lower lumbar spine procedures."2.71The effect of spinal bupivacaine in combination with either epidural clonidine and/or 0.5% bupivacaine administered at the incision site on postoperative outcome in patients undergoing lumbar laminectomy. ( Abodeely, A; Fluder, EM; Jellish, WS; Shea, J, 2003)
"The efficiency of bilateral paravertebral blockade combined with general anaesthesia (active) vs."2.71General anaesthesia combined with bilateral paravertebral blockade (T5-6) vs. general anaesthesia for laparoscopic cholecystectomy: a prospective, randomized clinical trial. ( Lönnqvist, PA; Naja, MZ; Ziade, MF, 2004)
"The incidence of immediate postoperative pain (0-2 h), as assessed by repeated Objective Pain Scale (OPS) scores, was chosen as the primary end-point of the study."2.71Clonidine vs. midazolam as premedication in children undergoing adeno-tonsillectomy: a prospective, randomized, controlled clinical trial. ( Bergendahl, HT; Eksborg, S; Lönnqvist, PA; Nordenberg, L; Oddby, E; Ruthström, E; Zetterqvist, H, 2004)
"To determine whether a low dose of spinal clonidine either alone or combined with sufentanil would provide effective analgesia following abdominal surgery, as a supplement to bupivacaine spinal anesthesia."2.69Low-dose intrathecal clonidine combined with sufentanil as analgesic drugs in abdominal gynecological surgery. ( Julião, MC; Lauretti, GR, 2000)
"Clonidine has antiemetic and analgesic properties and thus may be used as premedication to reduce postoperative vomiting and pain."2.61Safety and efficacy of clonidine on postoperative vomiting and pain in pediatric ophthalmic surgery: A systematic review and meta-analysis. ( Bai, CH; Chen, C; Chu, KC; Hsu, CW; Hsu, YP; Huang, CJ, 2019)
"Neostigmine and tramadol increase the probability for post-operative nausea or vomiting (PONV)."2.48Bayesian enhanced meta-analysis of post-operative analgesic efficacy of additives for caudal analgesia in children. ( Engelman, E; Marsala, C, 2012)
"There is considerable evidence that caudally administered clonidine in addition to local anesthetics provides extended duration of analgesia with a decreased incidence for analgesic rescue requirement and little adverse effects compared to caudal local anesthetics alone."2.47Efficacy and safety of clonidine as additive for caudal regional anesthesia: a quantitative systematic review of randomized controlled trials. ( Poepping, DM; Pogatzki-Zahn, EM; Schnabel, A; Zahn, PK, 2011)

Research

Studies (39)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's19 (48.72)29.6817
2010's20 (51.28)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Sanchez Munoz, MC1
De Kock, M1
Forget, P1
Zhang, Y1
Zhang, X1
Wang, Y1
Zhang, J1
Masud, M1
Yeasmeen, S1
Haque, AK1
Jahan, S1
Saha, NC1
Banik, D1
Samieirad, S1
Sharifian-Attar, A1
Eshghpour, M1
Mianbandi, V1
Shadkam, E1
Hosseini-Abrishami, M1
Hashemipour, MS1
Afshari, A1
Dereu, D1
Savoldelli, GL1
Mercier, Y1
Combescure, C1
Mathivon, S1
Rehberg, B1
Hsu, YP1
Chu, KC1
Bai, CH1
Huang, CJ1
Chen, C1
Hsu, CW1
Tietje, T1
Davis, AB1
Rivey, MP1
Carvalho, FA1
Tenório, SB1
Shiohara, FT1
Maia, LR1
Mota, A1
Vlok, R1
Melhuish, TM1
Chong, C1
Ryan, T1
White, LD1
Farmery, AD1
Wilson-MacDonald, J1
Dahmani, S1
Brasher, C1
Stany, I1
Golmard, J1
Skhiri, A1
Bruneau, B1
Nivoche, Y1
Constant, I1
Murat, I1
Zalunardo, MP1
Ivleva-Sauerborn, A1
Seifert, B1
Spahn, DR1
Taheri, A1
Javadimanesh, MA1
Ashraf, H1
Disma, N1
Frawley, G1
Mameli, L1
Pistorio, A1
Alberighi, OD1
Montobbio, G1
Tuo, P1
Schnabel, A1
Poepping, DM1
Pogatzki-Zahn, EM1
Zahn, PK1
Engelman, E2
Marsala, C2
Apostolos, K1
Georgios, K1
Omiros, C1
Christos, T1
Blaudszun, G1
Lysakowski, C1
Elia, N1
Tramèr, MR1
Almenrader, N1
Haiberger, R1
Passariello, M1
Gulhas, N1
Turkoz, A1
Durmus, M1
Togal, T1
Gedik, E1
Ersoy, MO1
Gürses, E1
Sungurtekin, H1
Tomatir, E1
Balci, C1
Gönüllü, M1
Jellish, WS1
Abodeely, A1
Fluder, EM1
Shea, J1
Grottke, O1
Müller, J1
Dietrich, PJ1
Krause, TH1
Wappler, F1
Klamt, JG1
Garcia, LV1
Stocche, RM1
Meinberg, AC1
Joshi, W1
Connelly, NR1
Freeman, K1
Reuben, SS1
Naja, MZ1
Ziade, MF1
Lönnqvist, PA3
Bergendahl, HT2
Eksborg, S2
Ruthström, E1
Nordenberg, L1
Zetterqvist, H1
Oddby, E1
Palmer, GM1
Cameron, DJ1
Dalsasso, M1
Tresin, P1
Innocente, F1
Veronese, S1
Ori, C1
Zhao, H1
Ishiyama, T1
Oguchi, T1
Kumazawa, T1
Ball, AM1
Smith, KM1
Contreras-Dominguez, V1
Carbonell-Bellolioa, P1
Ojeda-Greciet, A1
Sanzana, ES1
Kaabachi, O1
Zarghouni, A1
Ouezini, R1
Abdelaziz, AB1
Chattaoui, O1
Kokki, H1
Frank, T1
Thieme, V1
Radow, L1
Julião, MC1
Lauretti, GR1
Handa, F1
Fujii, Y1
Oddby-Muhrbeck, E1
Muhrbeck, O1

Clinical Trials (10)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Clonidine for Tourniquet-related Pain in Children: A Pilot Study[NCT04564430]Phase 420 participants (Anticipated)Interventional2021-03-01Recruiting
Transversus Abdominis Plane (TAP) Block Versus Intrathecal Morphine for Caesarean Section - Randomised Controlled Trial[NCT01931215]Phase 4180 participants (Actual)Interventional2013-09-30Completed
Randomized, Controlled Trial of Post-operative Steroids and Pain Control After Tonsillectomy[NCT03995628]Phase 2150 participants (Anticipated)Interventional2018-12-18Recruiting
Effects of Premedication by Midazolam on Preoperative Anxiety for Emergency Surgery[NCT02213302]Phase 459 participants (Actual)Interventional2014-07-31Completed
A Prospective Study Comparing Total Intravenous Anesthesia With Propofol and Remifentanil vs. Propofol and Dexmedetomidine in Adolescent Idiopathic Scoliosis Patients Undergoing Posterior Spinal Fusion and Instrumentation[NCT06096181]Phase 2120 participants (Anticipated)Interventional2023-12-31Not yet recruiting
Intravenous Lidocaine and Time to Regression of the Sensory Block After Spinal Anesthesia With Isobaric Bupivacaine in Patients Undergoing Surgery to Treat Skin and Soft Tissue Tumors of the Lower Limbs[NCT04741880]Phase 2/Phase 366 participants (Anticipated)Interventional2021-06-17Recruiting
Guanfacine for PONV and Pain After Sinus Surgery[NCT02882854]84 participants (Actual)Interventional2016-11-30Completed
A Comparison of Morphine and Morphine Plus Dexmedetomidine in Chronic Cancer Pain[NCT02289261]Phase 440 participants (Actual)Interventional2014-11-30Completed
Dexmedetomidine Comme Adjuvant à la rachianesthésie Lors de césariennes électives : Une étude Pilote[NCT05099055]Phase 342 participants (Actual)Interventional2022-03-15Completed
Effects of Clonidine and Midazolam Premedication on Bispectral Index and Recovery After Elective Surgery[NCT00638729]60 participants (Actual)Interventional2005-08-31Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

PACU Length of Stay in Minutes

(NCT02882854)
Timeframe: Time frame between arrival and discharge in PACU, approximately 90 minutes

Interventionminutes (Median)
Guanfacine128
Placebo110

Postoperative Nausea Assessment Using 11-point Nausea Scale (nVRS)

PONV assessed using nVRS at 24 hours postop when 0 is no nausea and 10 is worst nausea. (NCT02882854)
Timeframe: 24 hours post op

Interventionscore on a scale (Median)
Guanfacine0.00
Placebo0.00

Postoperative Pain Assessment Using 11-point Visual/Verbal Analog (VAS)

Postoperative pain assessment using VAS at 24 hours postop when 0 is no pain and 10 is worst pain (NCT02882854)
Timeframe: 24 hours postop

Interventionscore on a scale (Median)
Guanfacine3
Placebo2

Total Narcotic Requirement in PACU

Total narcotic requirement in PACU tallied in morphine equivalents during PACU stay (NCT02882854)
Timeframe: Time frame between arrival and discharge in PACU, approximately 90 minutes

Interventionmorphine equivalents (Median)
Guanfacine8.75
Placebo7.50

Maximum Postoperative Pain Assessment Using 11-point Visual/Verbal Analog (VAS)

Maximum postoperative pain assessment assessed in PACU at 15, 30 and 60 minutes after PACU arrival using VAS when 0 is no pain and 10 is worst pain (NCT02882854)
Timeframe: 15, 30, 60 minutes after arriving in PACU

InterventionParticipants (Count of Participants)
15 minutes after PACU admission7248297715 minutes after PACU admission7248297830 minutes after PACU admission7248297730 minutes after PACU admission7248297860 minutes after PACU admission7248297760 minutes after PACU admission72482978
Mild (Pain nVRS 1-5)Moderate/Severe (Pain nVRS 6-10)None (Pain nVRS 0)
Guanfacine31
Placebo24
Guanfacine0
Placebo5
Guanfacine8
Placebo10
Guanfacine18
Placebo20
Guanfacine7
Placebo6
Guanfacine14
Placebo14
Guanfacine12
Placebo16
Guanfacine6
Placebo13
Guanfacine21
Placebo12

Reviews

11 reviews available for clonidine and Emesis, Postoperative

ArticleYear
What is the place of clonidine in anesthesia? Systematic review and meta-analyses of randomized controlled trials.
    Journal of clinical anesthesia, 2017, Volume: 38

    Topics: Adrenergic alpha-2 Receptor Agonists; Analgesics; Anesthesia; Clonidine; Heart; Hemodynamics; Humans

2017
Effect of Clonidine on Hemodynamic Responses During Laparoscopic Cholecystectomy: A Systematic Review and Meta-Analysis.
    Surgical laparoscopy, endoscopy & percutaneous techniques, 2017, Volume: 27, Issue:5

    Topics: Adrenergic alpha-2 Receptor Agonists; Antihypertensive Agents; Arterial Pressure; Cholecystectomy, L

2017
Clonidine in pediatric anesthesia: the new panacea or a drug still looking for an indication?
    Current opinion in anaesthesiology, 2019, Volume: 32, Issue:3

    Topics: Adrenergic alpha-2 Receptor Agonists; Age Factors; Anesthesia; Child; Clonidine; Emergence Delirium;

2019
Safety and efficacy of clonidine on postoperative vomiting and pain in pediatric ophthalmic surgery: A systematic review and meta-analysis.
    Paediatric anaesthesia, 2019, Volume: 29, Issue:10

    Topics: Analgesics; Antiemetics; Child; Clonidine; Humans; Pain, Postoperative; Postoperative Nausea and Vom

2019
Adjuncts to local anaesthetics in tonsillectomy: a systematic review and meta-analysis.
    Journal of anesthesia, 2017, Volume: 31, Issue:4

    Topics: Anesthetics, Local; Clonidine; Dexamethasone; Humans; Laryngismus; Nerve Block; Pain, Postoperative;

2017
Premedication with clonidine is superior to benzodiazepines. A meta analysis of published studies.
    Acta anaesthesiologica Scandinavica, 2010, Volume: 54, Issue:4

    Topics: Adrenergic alpha-Agonists; Anesthesia Recovery Period; Benzodiazepines; Child; Child, Preschool; Clo

2010
Efficacy and safety of clonidine as additive for caudal regional anesthesia: a quantitative systematic review of randomized controlled trials.
    Paediatric anaesthesia, 2011, Volume: 21, Issue:12

    Topics: Analgesics; Anesthesia, Caudal; Child; Clonidine; Humans; Pain, Postoperative; Postoperative Nausea

2011
Bayesian enhanced meta-analysis of post-operative analgesic efficacy of additives for caudal analgesia in children.
    Acta anaesthesiologica Scandinavica, 2012, Volume: 56, Issue:7

    Topics: Adjuvants, Anesthesia; Adolescent; Analgesics; Analgesics, Opioid; Anesthetics, Inhalation; Anesthet

2012
Effect of perioperative systemic α2 agonists on postoperative morphine consumption and pain intensity: systematic review and meta-analysis of randomized controlled trials.
    Anesthesiology, 2012, Volume: 116, Issue:6

    Topics: Adrenergic alpha-2 Receptor Agonists; Analgesics, Opioid; Anesthesia Recovery Period; Clonidine; Dex

2012
Effect of perioperative systemic α2 agonists on postoperative morphine consumption and pain intensity: systematic review and meta-analysis of randomized controlled trials.
    Anesthesiology, 2012, Volume: 116, Issue:6

    Topics: Adrenergic alpha-2 Receptor Agonists; Analgesics, Opioid; Anesthesia Recovery Period; Clonidine; Dex

2012
Effect of perioperative systemic α2 agonists on postoperative morphine consumption and pain intensity: systematic review and meta-analysis of randomized controlled trials.
    Anesthesiology, 2012, Volume: 116, Issue:6

    Topics: Adrenergic alpha-2 Receptor Agonists; Analgesics, Opioid; Anesthesia Recovery Period; Clonidine; Dex

2012
Effect of perioperative systemic α2 agonists on postoperative morphine consumption and pain intensity: systematic review and meta-analysis of randomized controlled trials.
    Anesthesiology, 2012, Volume: 116, Issue:6

    Topics: Adrenergic alpha-2 Receptor Agonists; Analgesics, Opioid; Anesthesia Recovery Period; Clonidine; Dex

2012
Effect of perioperative systemic α2 agonists on postoperative morphine consumption and pain intensity: systematic review and meta-analysis of randomized controlled trials.
    Anesthesiology, 2012, Volume: 116, Issue:6

    Topics: Adrenergic alpha-2 Receptor Agonists; Analgesics, Opioid; Anesthesia Recovery Period; Clonidine; Dex

2012
Effect of perioperative systemic α2 agonists on postoperative morphine consumption and pain intensity: systematic review and meta-analysis of randomized controlled trials.
    Anesthesiology, 2012, Volume: 116, Issue:6

    Topics: Adrenergic alpha-2 Receptor Agonists; Analgesics, Opioid; Anesthesia Recovery Period; Clonidine; Dex

2012
Effect of perioperative systemic α2 agonists on postoperative morphine consumption and pain intensity: systematic review and meta-analysis of randomized controlled trials.
    Anesthesiology, 2012, Volume: 116, Issue:6

    Topics: Adrenergic alpha-2 Receptor Agonists; Analgesics, Opioid; Anesthesia Recovery Period; Clonidine; Dex

2012
Effect of perioperative systemic α2 agonists on postoperative morphine consumption and pain intensity: systematic review and meta-analysis of randomized controlled trials.
    Anesthesiology, 2012, Volume: 116, Issue:6

    Topics: Adrenergic alpha-2 Receptor Agonists; Analgesics, Opioid; Anesthesia Recovery Period; Clonidine; Dex

2012
Effect of perioperative systemic α2 agonists on postoperative morphine consumption and pain intensity: systematic review and meta-analysis of randomized controlled trials.
    Anesthesiology, 2012, Volume: 116, Issue:6

    Topics: Adrenergic alpha-2 Receptor Agonists; Analgesics, Opioid; Anesthesia Recovery Period; Clonidine; Dex

2012
Effect of perioperative systemic α2 agonists on postoperative morphine consumption and pain intensity: systematic review and meta-analysis of randomized controlled trials.
    Anesthesiology, 2012, Volume: 116, Issue:6

    Topics: Adrenergic alpha-2 Receptor Agonists; Analgesics, Opioid; Anesthesia Recovery Period; Clonidine; Dex

2012
Effect of perioperative systemic α2 agonists on postoperative morphine consumption and pain intensity: systematic review and meta-analysis of randomized controlled trials.
    Anesthesiology, 2012, Volume: 116, Issue:6

    Topics: Adrenergic alpha-2 Receptor Agonists; Analgesics, Opioid; Anesthesia Recovery Period; Clonidine; Dex

2012
Effect of perioperative systemic α2 agonists on postoperative morphine consumption and pain intensity: systematic review and meta-analysis of randomized controlled trials.
    Anesthesiology, 2012, Volume: 116, Issue:6

    Topics: Adrenergic alpha-2 Receptor Agonists; Analgesics, Opioid; Anesthesia Recovery Period; Clonidine; Dex

2012
Effect of perioperative systemic α2 agonists on postoperative morphine consumption and pain intensity: systematic review and meta-analysis of randomized controlled trials.
    Anesthesiology, 2012, Volume: 116, Issue:6

    Topics: Adrenergic alpha-2 Receptor Agonists; Analgesics, Opioid; Anesthesia Recovery Period; Clonidine; Dex

2012
Effect of perioperative systemic α2 agonists on postoperative morphine consumption and pain intensity: systematic review and meta-analysis of randomized controlled trials.
    Anesthesiology, 2012, Volume: 116, Issue:6

    Topics: Adrenergic alpha-2 Receptor Agonists; Analgesics, Opioid; Anesthesia Recovery Period; Clonidine; Dex

2012
Effect of perioperative systemic α2 agonists on postoperative morphine consumption and pain intensity: systematic review and meta-analysis of randomized controlled trials.
    Anesthesiology, 2012, Volume: 116, Issue:6

    Topics: Adrenergic alpha-2 Receptor Agonists; Analgesics, Opioid; Anesthesia Recovery Period; Clonidine; Dex

2012
Effect of perioperative systemic α2 agonists on postoperative morphine consumption and pain intensity: systematic review and meta-analysis of randomized controlled trials.
    Anesthesiology, 2012, Volume: 116, Issue:6

    Topics: Adrenergic alpha-2 Receptor Agonists; Analgesics, Opioid; Anesthesia Recovery Period; Clonidine; Dex

2012
Efficacy of adding clonidine to intrathecal morphine in acute postoperative pain: meta-analysis.
    British journal of anaesthesia, 2013, Volume: 110, Issue:1

    Topics: Acute Pain; Adrenergic alpha-Agonists; Analgesics, Opioid; Clonidine; Endpoint Determination; Fentan

2013
Postoperative pain management: can transdermal patches help?
    Orthopedics, 2006, Volume: 29, Issue:3

    Topics: Administration, Cutaneous; Analgesics; Anesthetics, Local; Antiemetics; Clonidine; Fentanyl; Humans;

2006

Trials

26 trials available for clonidine and Emesis, Postoperative

ArticleYear
Role of Oral Clonidine Premedication on Intra-operative Haemodynamics and PONV in Laparoscopic Cholecystectomy.
    Mymensingh medical journal : MMJ, 2017, Volume: 26, Issue:4

    Topics: Adult; Analgesics; Bangladesh; Cholecystectomy, Laparoscopic; Clonidine; Double-Blind Method; Hemody

2017
Comparison of Ondansetron versus Clonidine efficacy for prevention of postoperative pain, nausea and vomiting after orthognathic surgeries: A triple blind randomized controlled trial.
    Medicina oral, patologia oral y cirugia bucal, 2018, Nov-01, Volume: 23, Issue:6

    Topics: Adolescent; Adult; Analgesics; Antiemetics; Clonidine; Double-Blind Method; Female; Humans; Male; On

2018
The impact of a transversus abdominis plane block including clonidine vs. intrathecal morphine on nausea and vomiting after caesarean section: A randomised controlled trial.
    European journal of anaesthesiology, 2019, Volume: 36, Issue:8

    Topics: Abdominal Muscles; Adult; Anesthesia, Obstetrical; Anesthesia, Spinal; Anesthetics, Local; Cesarean

2019
Randomized study of postcesarean analgesia with intrathecal morphine alone or combined with clonidine.
    Journal of clinical anesthesia, 2016, Volume: 33

    Topics: Adrenergic alpha-Agonists; Adult; Analgesics, Opioid; Cesarean Section; Clonidine; Double-Blind Meth

2016
The analgesic effect of epidural clonidine after spinal surgery: a randomized placebo-controlled trial.
    Anesthesia and analgesia, 2009, Volume: 108, Issue:2

    Topics: Adrenergic alpha-Agonists; Adult; Aged; Analgesia, Epidural; Blood Pressure; Clonidine; Double-Blind

2009
[Quality of premedication and patient satisfaction after premedication with midazolam, clonidine or placebo : Randomized double-blind study with age-adjusted dosage].
    Der Anaesthesist, 2010, Volume: 59, Issue:5

    Topics: Adolescent; Adrenergic alpha-Agonists; Adult; Aged; Aging; Anesthesia; Anxiety; Blood Gas Analysis;

2010
The effect of oral clonidine premedication on nausea and vomiting after ear surgery.
    Middle East journal of anaesthesiology, 2010, Volume: 20, Issue:5

    Topics: Administration, Oral; Adult; Clonidine; Double-Blind Method; Ear; Female; Humans; Male; Postoperativ

2010
Effect of epidural clonidine on minimum local anesthetic concentration (ED50) of levobupivacaine for caudal block in children.
    Paediatric anaesthesia, 2011, Volume: 21, Issue:2

    Topics: Adjuvants, Anesthesia; Adrenergic alpha-Agonists; Analgesia, Epidural; Anesthesia, Caudal; Anestheti

2011
Comparison between ropivacaine 1.5 mg ml(-1) plus fentanyl 2 mg ml(-1) and ropivacaine 1.5 mg ml(-1) plus clonidine 1 mg ml(-1) as analgesic solution after anterior cruciate ligament reconstruction: a randomized clinical trial.
    Middle East journal of anaesthesiology, 2011, Volume: 21, Issue:3

    Topics: Adrenergic alpha-Agonists; Adult; Amides; Anesthetics, Intravenous; Anesthetics, Local; Anterior Cru

2011
Steal induction in preschool children: is melatonin as good as clonidine? A prospective, randomized study.
    Paediatric anaesthesia, 2013, Volume: 23, Issue:4

    Topics: Adrenergic alpha-Agonists; Anesthesia, Inhalation; Child, Preschool; Clonidine; Electroencephalograp

2013
Oral clonidine premedication does not reduce postoperative vomiting in children undergoing strabismus surgery.
    Acta anaesthesiologica Scandinavica, 2003, Volume: 47, Issue:1

    Topics: Adrenergic alpha-Agonists; Child; Child, Preschool; Clonidine; Double-Blind Method; Female; Humans;

2003
The addition of droperidol or clonidine to epidural tramadol shortens onset time and increases duration of postoperative analgesia.
    Canadian journal of anaesthesia = Journal canadien d'anesthesie, 2003, Volume: 50, Issue:2

    Topics: Abdomen; Adjuvants, Anesthesia; Adrenergic alpha-Agonists; Adult; Aged; Analgesia, Epidural; Analges

2003
The effect of spinal bupivacaine in combination with either epidural clonidine and/or 0.5% bupivacaine administered at the incision site on postoperative outcome in patients undergoing lumbar laminectomy.
    Anesthesia and analgesia, 2003, Volume: 96, Issue:3

    Topics: Adrenergic alpha-Agonists; Aged; Anesthesia Recovery Period; Anesthesia, Epidural; Anesthesia, Spina

2003
[Comparison of premedication with clonidine and midazolam combined with TCI for orthopaedic shoulder surgery].
    Anasthesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie : AINS, 2003, Volume: 38, Issue:12

    Topics: Adolescent; Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-Agonists; Adult; Aged; Analgesia,

2003
Epidural infusion of clonidine or clonidine plus ropivacaine for postoperative analgesia in children undergoing major abdominal surgery.
    Journal of clinical anesthesia, 2003, Volume: 15, Issue:7

    Topics: Abdomen; Adrenergic alpha-Agonists; Amides; Analgesia, Epidural; Analgesics, Opioid; Anesthetics, Lo

2003
Analgesic effect of clonidine added to bupivacaine 0.125% in paediatric caudal blockade.
    Paediatric anaesthesia, 2004, Volume: 14, Issue:6

    Topics: Adrenergic alpha-Agonists; Analgesics; Anesthesia, Caudal; Anesthetics, Local; Bupivacaine; Child, P

2004
General anaesthesia combined with bilateral paravertebral blockade (T5-6) vs. general anaesthesia for laparoscopic cholecystectomy: a prospective, randomized clinical trial.
    European journal of anaesthesiology, 2004, Volume: 21, Issue:6

    Topics: Analgesics; Analgesics, Opioid; Anesthesia, General; Anesthetics, Local; Bupivacaine; Cholecystectom

2004
Clonidine vs. midazolam as premedication in children undergoing adeno-tonsillectomy: a prospective, randomized, controlled clinical trial.
    Acta anaesthesiologica Scandinavica, 2004, Volume: 48, Issue:10

    Topics: Adenoidectomy; Adrenergic alpha-Agonists; Anesthesia; Behavior; Child; Child, Preschool; Clonidine;

2004
Low-dose ketamine with clonidine and midazolam for adult day care surgery.
    European journal of anaesthesiology, 2005, Volume: 22, Issue:1

    Topics: Adrenergic alpha-Agonists; Adult; Ambulatory Surgical Procedures; Anesthesia Recovery Period; Anesth

2005
[Effects of clonidine and midazolam on postoperative shivering, nausea, and vomiting].
    Masui. The Japanese journal of anesthesiology, 2005, Volume: 54, Issue:11

    Topics: Administration, Oral; Aged; Anesthesia, Epidural; Anesthesia, General; Clonidine; Female; Humans; Ma

2005
[Femoral nerve block for postoperative analgesia after anterior cruciate ligament reconstruction: comparison of 2 concentrations of bupivacaine with clonidine in 3 modes of administration].
    Revista espanola de anestesiologia y reanimacion, 2006, Volume: 53, Issue:10

    Topics: Adolescent; Adult; Analgesia, Patient-Controlled; Analgesics; Analgesics, Non-Narcotic; Anesthetics,

2006
Clonidine 1 microg/kg is a safe and effective adjuvant to plain bupivacaine in spinal anesthesia in adolescents.
    Anesthesia and analgesia, 2007, Volume: 105, Issue:2

    Topics: Adjuvants, Pharmaceutic; Adolescent; Anesthesia, Spinal; Bupivacaine; Child; Clonidine; Double-Blind

2007
[Premedication in maxillofacial surgery under total intravenous anesthesia . Effects of clonidine compared to midazolam on the perioperative course].
    Anasthesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie : AINS, 2000, Volume: 35, Issue:7

    Topics: Adjuvants, Anesthesia; Adrenergic alpha-Agonists; Adult; Anesthesia, Intravenous; Clonidine; Double-

2000
Low-dose intrathecal clonidine combined with sufentanil as analgesic drugs in abdominal gynecological surgery.
    Journal of clinical anesthesia, 2000, Volume: 12, Issue:5

    Topics: Abdomen; Adrenergic alpha-Agonists; Adult; Analgesics; Analgesics, Opioid; Blood Pressure; Clonidine

2000
The efficacy of oral clonidine premedication in the prevention of postoperative vomiting in children following strabismus surgery.
    Paediatric anaesthesia, 2001, Volume: 11, Issue:1

    Topics: Administration, Oral; Adrenergic alpha-Agonists; Anesthetics, Combined; Anesthetics, Inhalation; Ane

2001
Effects of clonidine on postoperative nausea and vomiting in breast cancer surgery.
    Anesthesiology, 2002, Volume: 96, Issue:5

    Topics: Adrenergic alpha-Agonists; Aged; Anesthesia, General; Antiemetics; Blood Pressure; Breast Neoplasms;

2002

Other Studies

2 other studies available for clonidine and Emesis, Postoperative

ArticleYear
Comparison of 2 Methods of Local Anesthetic-Based Injection as Part of a Multimodal Approach to Pain Management After Total Knee Arthroplasty.
    Journal of pharmacy practice, 2015, Volume: 28, Issue:6

    Topics: Aged; Amides; Analgesics; Anesthetics, Local; Anti-Inflammatory Agents, Non-Steroidal; Arthroplasty,

2015
Use of intravenous midazolam and clonidine in cyclical vomiting syndrome: a case report.
    Paediatric anaesthesia, 2005, Volume: 15, Issue:1

    Topics: Adrenergic alpha-Agonists; Child; Clonidine; Drug Therapy, Combination; Humans; Hypnotics and Sedati

2005