clonidine has been researched along with Electrocardiogram QT Prolonged in 6 studies
Clonidine: An imidazoline sympatholytic agent that stimulates ALPHA-2 ADRENERGIC RECEPTORS and central IMIDAZOLINE RECEPTORS. It is commonly used in the management of HYPERTENSION.
clonidine (amino form) : A clonidine that is 4,5-dihydro-1H-imidazol-2-amine in which one of the amino hydrogens is replaced by a 2,6-dichlorophenyl group.
| Excerpt | Relevance | Reference |
|---|---|---|
| " To test this hypothesis, the effects of 2 clinically available α-2 AR agonists (dexmedetomidine and clonidine) on the occurrence of VTs were assessed in a methoxamine-sensitized rabbit model of acquired long QT syndrome (Study 1: n=45)." | 7.78 | Dexmedetomidine and clonidine inhibit ventricular tachyarrhythmias in a rabbit model of acquired long QT syndrome. ( Ajiki, K; Hayami, N; Kanamori, K; Kunishima, T; Mikamo, T; Murakawa, Y; Sugiura, A; Tsutsui, K; Watanabe, H; Yamagishi, N; Yamagishi, S, 2012) |
| "There were more incidents of bradycardia in subjects treated with clonidine compared with those not treated with clonidine (17." | 5.13 | Clonidine for attention-deficit/hyperactivity disorder: II. ECG changes and adverse events analysis. ( Bukstein, OG; Daviss, WB; Harris, P; McDERMOTT, MP; Palumbo, D; Patel, NC; Pelham, WE; Robb, AS; Sallee, FR, 2008) |
| " Several studies have shown that panic disorder is associated with an increased sensitivity to yohimbine and a blunted growth hormone response to clonidine, which are alpha-2 adrenoceptor antagonist and agonist, respectively." | 5.10 | Heart rate and QT interval variability: abnormal alpha-2 adrenergic function in patients with panic disorder. ( Tancer, M; Uhde, T; Yeragani, VK, 2003) |
| " To test this hypothesis, the effects of 2 clinically available α-2 AR agonists (dexmedetomidine and clonidine) on the occurrence of VTs were assessed in a methoxamine-sensitized rabbit model of acquired long QT syndrome (Study 1: n=45)." | 3.78 | Dexmedetomidine and clonidine inhibit ventricular tachyarrhythmias in a rabbit model of acquired long QT syndrome. ( Ajiki, K; Hayami, N; Kanamori, K; Kunishima, T; Mikamo, T; Murakawa, Y; Sugiura, A; Tsutsui, K; Watanabe, H; Yamagishi, N; Yamagishi, S, 2012) |
| " We aimed to quantify co-administration of MQAB with interacting drugs and associated adverse drug reactions." | 1.43 | Drug safety of macrolide and quinolone antibiotics in a tertiary care hospital: administration of interacting co-medication and QT prolongation. ( Corti, N; Hoppe, L; Kovari, H; Maechler, S; Niedrig, D; Russmann, S, 2016) |
| "Tizanidine (Zanaflex) is a centrally acting imidazoline muscle relaxant that is structurally similar to clonidine (α(2)-adrenergic agonist) but not to other myorelaxants such as baclofen or benzodiazepines." | 1.38 | Tizanidine (Zanaflex): a muscle relaxant that may prolong the QT interval by blocking IKr. ( Drolet, B; Kaddar, N; Patoine, D; Pilote, S; Simard, C; Vigneault, P, 2012) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (50.00) | 29.6817 |
| 2010's | 3 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Niedrig, D | 1 |
| Maechler, S | 1 |
| Hoppe, L | 1 |
| Corti, N | 1 |
| Kovari, H | 1 |
| Russmann, S | 1 |
| Kaddar, N | 1 |
| Vigneault, P | 1 |
| Pilote, S | 1 |
| Patoine, D | 1 |
| Simard, C | 1 |
| Drolet, B | 1 |
| Tsutsui, K | 1 |
| Hayami, N | 1 |
| Kunishima, T | 1 |
| Sugiura, A | 1 |
| Mikamo, T | 1 |
| Kanamori, K | 1 |
| Yamagishi, N | 1 |
| Yamagishi, S | 1 |
| Watanabe, H | 1 |
| Ajiki, K | 1 |
| Murakawa, Y | 1 |
| Yeragani, VK | 1 |
| Tancer, M | 1 |
| Uhde, T | 1 |
| Schmittner, J | 1 |
| Schroeder, JR | 1 |
| Epstein, DH | 1 |
| Preston, KL | 1 |
| Daviss, WB | 1 |
| Patel, NC | 1 |
| Robb, AS | 1 |
| McDERMOTT, MP | 1 |
| Bukstein, OG | 1 |
| Pelham, WE | 1 |
| Palumbo, D | 1 |
| Harris, P | 1 |
| Sallee, FR | 1 |
2 trials available for clonidine and Electrocardiogram QT Prolonged
| Article | Year |
|---|---|
Heart rate and QT interval variability: abnormal alpha-2 adrenergic function in patients with panic disorder.
Topics: Adrenergic alpha-Agonists; Adult; Clonidine; Double-Blind Method; Female; Heart Rate; Humans; Long Q | 2003 |
Clonidine for attention-deficit/hyperactivity disorder: II. ECG changes and adverse events analysis.
Topics: Adrenergic alpha-Agonists; Attention Deficit Disorder with Hyperactivity; Bradycardia; Central Nervo | 2008 |
4 other studies available for clonidine and Electrocardiogram QT Prolonged
| Article | Year |
|---|---|
Drug safety of macrolide and quinolone antibiotics in a tertiary care hospital: administration of interacting co-medication and QT prolongation.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anti-Bacterial Agents; Atorvastatin; Clonidine; Drug Int | 2016 |
Tizanidine (Zanaflex): a muscle relaxant that may prolong the QT interval by blocking IKr.
Topics: Animals; CHO Cells; Clonidine; Cricetinae; Cricetulus; Dose-Response Relationship, Drug; Guinea Pigs | 2012 |
Dexmedetomidine and clonidine inhibit ventricular tachyarrhythmias in a rabbit model of acquired long QT syndrome.
Topics: Adrenergic alpha-1 Receptor Agonists; Adrenergic alpha-2 Receptor Agonists; Animals; Anti-Arrhythmia | 2012 |
QT interval increased after single dose of lofexidine.
Topics: Adult; Clonidine; Female; Humans; Long QT Syndrome; Methadone; Narcotic Antagonists | 2004 |