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clonidine and Dyskinesia, Drug-Induced

clonidine has been researched along with Dyskinesia, Drug-Induced in 24 studies

Clonidine: An imidazoline sympatholytic agent that stimulates ALPHA-2 ADRENERGIC RECEPTORS and central IMIDAZOLINE RECEPTORS. It is commonly used in the management of HYPERTENSION.
clonidine (amino form) : A clonidine that is 4,5-dihydro-1H-imidazol-2-amine in which one of the amino hydrogens is replaced by a 2,6-dichlorophenyl group.

Dyskinesia, Drug-Induced: Abnormal movements, including HYPERKINESIS; HYPOKINESIA; TREMOR; and DYSTONIA, associated with the use of certain medications or drugs. Muscles of the face, trunk, neck, and extremities are most commonly affected. Tardive dyskinesia refers to abnormal hyperkinetic movements of the muscles of the face, tongue, and neck associated with the use of neuroleptic agents (see ANTIPSYCHOTIC AGENTS). (Adams et al., Principles of Neurology, 6th ed, p1199)

Research Excerpts

ExcerptRelevanceReference
"Clonidine was selected because it blocks noradrenergic but not dopaminergic neurotransmission."6.65Clonidine treatment of schizophrenia. Double-blind comparison to placebo and neuroleptic drugs. ( Adler, LE; Bell, J; Denver, P; Freedman, R; Kirch, D; Pachtman, E; Pecevich, M, 1982)
"Clonidine's actions and efficacy in mental disorders are reviewed and examined."5.06Psychiatric indications for clonidine: the neuropharmacologic and clinical basis. ( Bond, WS, 1986)
" The aims of this study were therefore (1) to investigate the anti-dyskinetic effects of piribedil on L-DOPA-induced contralateral turning behaviour, locomotive dyskinesias (LD), axial dystonia (AD), orolingual dyskinesia (OD) and forelimb dyskinesia (FD) and (2) to compare these effects to the α(2) adrenoceptor antagonist, idazoxan, or the α(2) adrenoceptor agonist, clonidine."3.79The effect of piribedil on L-DOPA-induced dyskinesias in a rat model of Parkinson's disease: differential role of α(2) adrenergic mechanisms. ( Gerlach, M; Halley, P; Riederer, P; van den Buuse, M, 2013)
"Twenty-nine patients with tardive dyskinesia (n = 20) or related syndromes [spontaneous dyskinesia (n = 3), levodopa-induced dyskinesia (n = 3), tardive dystonia (n = 3)] were treated with clonidine."3.67Clonidine therapy for tardive dyskinesia and related syndromes. ( Koga, I; Nishikawa, T; Tanaka, M; Tsuda, A; Uchida, Y, 1984)
"Three cases of tardive dyskinesia with psychotic symptoms (one presenile psychosis; two schizophrenia) were successfully treated with both clonidine and neuroleptics for 3 years."3.66Combined treatment of tardive dyskinesia with clonidine and neuroleptics: a follow-up study of three cases for three years. ( Koga, I; Nishikawa, T; Tanaka, M; Uchida, Y, 1983)
"Clonidine was administered to twelve chronic schizophrenic patients with TDS in a double-blind, cross-over, single-dose trial."2.66Clonidine trial in tardive dyskinesia. Therapeutic response, MHPG, and plasma DBH. ( Markianos, M; Tripodianakis, J, 1986)
"Clonidine was selected because it blocks noradrenergic but not dopaminergic neurotransmission."2.65Clonidine treatment of schizophrenia. Double-blind comparison to placebo and neuroleptic drugs. ( Adler, LE; Bell, J; Denver, P; Freedman, R; Kirch, D; Pachtman, E; Pecevich, M, 1982)
"Baclofen was also useful in one monkey against a more dystonic form of dyskinesia."1.29Effect of nondopaminergic drugs on L-dopa-induced dyskinesias in MPTP-treated monkeys. ( Bédard, PJ; Gomez-Mancilla, B, 1993)

Research

Studies (24)

TimeframeStudies, this research(%)All Research%
pre-199015 (62.50)18.7374
1990's5 (20.83)18.2507
2000's2 (8.33)29.6817
2010's2 (8.33)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Ostock, CY1
Hallmark, J1
Palumbo, N1
Bhide, N1
Conti, M1
George, JA1
Bishop, C1
Gerlach, M1
Halley, P1
Riederer, P1
van den Buuse, M1
McGavin, CL1
John, V1
Musser, WS1
Freedman, R2
Bell, J2
Kirch, D2
Nishikawa, T3
Tanaka, M3
Koga, I3
Uchida, Y3
Adler, LE1
Pecevich, M1
Pachtman, E1
Denver, P1
Johnson, JM1
Tsuda, A1
Lechin, F1
van der Dijs, B1
Gomez-Mancilla, B1
Bédard, PJ1
Kazamatsuri, H1
Henry, B1
Crossman, AR1
Brotchie, JM1
Maj, J1
Rogóz, Z1
Dlaboga, D1
Dziedzicka-Wasylewska, M1
Tanii, H1
Hayashi, M1
Hashimoto, K1
Sachdev, P1
Chee, KY1
Singh, S1
Subramaniam, M1
Browne, J1
Silver, H1
Martin, R1
Hart, R1
Mergener, M1
Williams, P1
Svensson, TH1
Khot, V1
Goodwin, J1
Wandry, G1
Cadet, JL1
Braun, T1
Freed, WJ1
Troung, DD1
Bressman, S1
Shale, H1
Fahn, S1
Bond, WS1
Tripodianakis, J1
Markianos, M1

Reviews

3 reviews available for clonidine and Dyskinesia, Drug-Induced

ArticleYear
Psychiatric uses of antiadrenergic and adrenergic blocking drugs.
    The Journal of nervous and mental disease, 1984, Volume: 172, Issue:3

    Topics: Adult; Alcohol Amnestic Disorder; Antipsychotic Agents; Bipolar Disorder; Clinical Trials as Topic;

1984
[Tardive dyskinesia--diagnosis and treatment].
    Nihon rinsho. Japanese journal of clinical medicine, 1993, Volume: 51, Issue:11

    Topics: Clonidine; Diagnosis, Differential; Dyskinesia, Drug-Induced; Humans; Middle Aged; Psychotropic Drug

1993
Clonidine in abstinence reactions: basic mechanisms.
    Acta psychiatrica Scandinavica. Supplementum, 1986, Volume: 327

    Topics: Adrenergic alpha-Agonists; Animals; Anxiety Disorders; Autonomic Nervous System; Central Nervous Sys

1986

Trials

7 trials available for clonidine and Dyskinesia, Drug-Induced

ArticleYear
Clonidine treatment of schizophrenia. Double-blind comparison to placebo and neuroleptic drugs.
    Acta psychiatrica Scandinavica, 1982, Volume: 65, Issue:1

    Topics: Adolescent; Adult; Aged; Antipsychotic Agents; Blood Pressure; Clinical Trials as Topic; Clonidine;

1982
Psychiatric uses of antiadrenergic and adrenergic blocking drugs.
    The Journal of nervous and mental disease, 1984, Volume: 172, Issue:3

    Topics: Adult; Alcohol Amnestic Disorder; Antipsychotic Agents; Bipolar Disorder; Clinical Trials as Topic;

1984
Pharmacological characterization of tardive akathisia.
    Biological psychiatry, 1990, Nov-01, Volume: 28, Issue:9

    Topics: Administration, Oral; Aged; Akathisia, Drug-Induced; Antipsychotic Agents; Arousal; Atenolol; Benztr

1990
The use of clonidine in the treatment of neuroleptic-induced tardive dyskinesia.
    Journal of clinical psychopharmacology, 1986, Volume: 6, Issue:2

    Topics: Adult; Antipsychotic Agents; Blood Pressure; Clinical Trials as Topic; Clonidine; Double-Blind Metho

1986
Clonazepam, haloperidol, and clonidine in tic disorders.
    Southern medical journal, 1988, Volume: 81, Issue:9

    Topics: Child; Clinical Trials as Topic; Clonazepam; Clonidine; Drug Therapy, Combination; Dyskinesia, Drug-

1988
Psychiatric indications for clonidine: the neuropharmacologic and clinical basis.
    Journal of clinical psychopharmacology, 1986, Volume: 6, Issue:2

    Topics: Animals; Anxiety; Bipolar Disorder; Clinical Trials as Topic; Clonidine; Double-Blind Method; Drug T

1986
Clonidine trial in tardive dyskinesia. Therapeutic response, MHPG, and plasma DBH.
    Pharmacopsychiatry, 1986, Volume: 19, Issue:5

    Topics: Adult; Clinical Trials as Topic; Clonidine; Dopamine beta-Hydroxylase; Double-Blind Method; Dyskines

1986

Other Studies

15 other studies available for clonidine and Dyskinesia, Drug-Induced

ArticleYear
Modulation of L-DOPA's antiparkinsonian and dyskinetic effects by α2-noradrenergic receptors within the locus coeruleus.
    Neuropharmacology, 2015, Volume: 95

    Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Animals; Antiparkinso

2015
The effect of piribedil on L-DOPA-induced dyskinesias in a rat model of Parkinson's disease: differential role of α(2) adrenergic mechanisms.
    Journal of neural transmission (Vienna, Austria : 1996), 2013, Volume: 120, Issue:1

    Topics: Adrenergic Agents; Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; An

2013
Levetiracetam as a treatment for tardive dyskinesia: a case report.
    Neurology, 2003, Aug-12, Volume: 61, Issue:3

    Topics: Adrenergic alpha-Agonists; Anticonvulsants; Antidepressive Agents; Chronic Disease; Clonidine; Depre

2003
Clonidine therapy for coexisting psychosis and tardive dyskinesia.
    The American journal of psychiatry, 1980, Volume: 137, Issue:5

    Topics: Adult; Antipsychotic Agents; Clonidine; Dyskinesia, Drug-Induced; Female; Humans; Male; Schizophreni

1980
Combined treatment of tardive dyskinesia with clonidine and neuroleptics: a follow-up study of three cases for three years.
    Psychopharmacology, 1983, Volume: 80, Issue:4

    Topics: Antipsychotic Agents; Clonidine; Dementia; Dyskinesia, Drug-Induced; Female; Follow-Up Studies; Huma

1983
Clonidine therapy for tardive dyskinesia and related syndromes.
    Clinical neuropharmacology, 1984, Volume: 7, Issue:3

    Topics: Adult; Aged; Clonidine; Dyskinesia, Drug-Induced; Dystonia; Female; Humans; Levodopa; Male; Middle A

1984
Tardive dyskinesia treated with clonidine.
    The Kurume medical journal, 1980, Volume: 27, Issue:3

    Topics: Adult; Aged; Clonidine; Dyskinesia, Drug-Induced; Female; Humans; Male; Middle Aged

1980
Clonidine therapy for psychosis and tardive dyskinesia.
    The American journal of psychiatry, 1981, Volume: 138, Issue:3

    Topics: Clonidine; Dyskinesia, Drug-Induced; Humans; Psychotic Disorders

1981
Effect of nondopaminergic drugs on L-dopa-induced dyskinesias in MPTP-treated monkeys.
    Clinical neuropharmacology, 1993, Volume: 16, Issue:5

    Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Atropine; Baclofen; Clonidine; Dopamine Agent

1993
Characterization of enhanced behavioral responses to L-DOPA following repeated administration in the 6-hydroxydopamine-lesioned rat model of Parkinson's disease.
    Experimental neurology, 1998, Volume: 151, Issue:2

    Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Antiparkinson Agents; Behavior, An

1998
Pharmacological effects of milnacipran, a new antidepressant, given repeatedly on the alpha1-adrenergic and serotonergic 5-HT2A systems.
    Journal of neural transmission (Vienna, Austria : 1996), 2000, Volume: 107, Issue:11

    Topics: 5-Hydroxytryptophan; Adrenergic alpha-Agonists; Adrenergic Uptake Inhibitors; Aggression; Amphetamin

2000
Effects of neurotropic agents with a selectivity for alpha-adrenoceptors on nitrile-induced dyskinetic syndrome in mice.
    Pharmacology, biochemistry, and behavior, 1990, Volume: 36, Issue:2

    Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Clonidine; Dyskinesia, Drug-Induce

1990
Failure of clonidine in tardive dystonia: implications for nosology.
    Biological psychiatry, 1989, Volume: 26, Issue:2

    Topics: Adult; Antipsychotic Agents; Clonidine; Dose-Response Relationship, Drug; Drug Therapy, Combination;

1989
Time course of effects of clonidine.
    The American journal of psychiatry, 1987, Volume: 144, Issue:11

    Topics: Akathisia, Drug-Induced; Antipsychotic Agents; Clonidine; Dyskinesia, Drug-Induced; Humans; Psychomo

1987
Clonidine and prazosin block the iminodipropionitrile (IDPN)-induced spasmodic dyskinetic syndrome in mice.
    Pharmacology, biochemistry, and behavior, 1987, Volume: 26, Issue:4

    Topics: Animals; Clonidine; Dyskinesia, Drug-Induced; Male; Mice; Nitriles; Norepinephrine; Prazosin; Recept

1987